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Literature for peptidase S01.015: tryptase beta

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2020
  1. Giardina,S.F., Werner,D.S., Pingle,M., Feinberg,P.B., Foreman,K.W., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    Novel, self-assembling dimeric inhibitors of human beta tryptase
    J Med Chem63, 3004-3027. PubMed  Europe PubMed DOI  I
    2. 2018
  2. Giardina,S.F., Werner,D.S., Pingle,M., Foreman,K.W., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    Target-directed self-assembly of homodimeric drugs against beta-tryptase
    ACS Med Chem Lett9, 827-831. PubMed  Europe PubMed DOI  I
  3. Giardina,S.F., Werner,D.S., Pingle,M., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    A novel, nonpeptidic, orally active bivalent inhibitor of human beta-tryptase
    Pharmacology102, 233-243. PubMed  Europe PubMed DOI  S  I
    4. 2015
  4. Jiang,Q.-Q., Sicking,W., Ehlers,M. and Schmuck,C.
    Discovery of potent inhibitors of human beta-tryptase from pre-equilibrated dynamic combinatorial libraries
    Chem Sci6, 1792-1800. PubMed  Europe PubMed DOI  I
    5. 2014
  5. Wang,Q., Shi,X., Zhu,X., Ehlers,M., Wu,J. and Schmuck,C.
    A fluorescent light-up probe as an inhibitor of intracellular beta-tryptase
    Chem Commun (Camb)50, 6120-6122. PubMed  Europe PubMed DOI  L  I
    6. 2013
  6. Jiang,Q.Q., Bartsch,L., Sicking,W., Wich,P.R., Heider,D., Hoffmann,D. and Schmuck,C.
    A new approach to inhibit human beta-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms
    Org Biomol Chem11, 1631-1639. PubMed  Europe PubMed DOI  I
    7. 2012
  7. Liang,G., Aldous,S., Merriman,G., Levell,J., Pribish,J., Cairns,J., Chen,X., Maignan,S., Mathieu,M., Tsay,J., Sides,K., Rebello,S., Whitely,B., Morize,I. and Pauls,H.W.
    Structure-based library design and the discovery of a potent and selective mast cell beta-tryptase inhibitor as an oral therapeutic agent
    Bioorg Med Chem Lett22, 1049-1054. PubMed  Europe PubMed DOI  I
  8. Liang,G., Choi-Sledeski,Y.M., Shum,P., Chen,X., Poli,G.B., Kumar,V., Minnich,A., Wang,Q., Tsay,J., Sides,K., Kang,J. and Zhang,Y.
    A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity
    Bioorg Med Chem Lett22, 1606-1610. PubMed  Europe PubMed DOI  I
  9. Liang,G., Choi-Sledeski,Y.M., Chen,X., Gong,Y., Macmillan,E.W., Tsay,J., Sides,K., Cairns,J., Kulitzscher,B., Aldous,D.J., Morize,I. and Pauls,H.W.
    Dimerization of beta-tryptase inhibitors, does it work for both basic and neutral P1 groups?
    Bioorg Med Chem Lett22, 3370-3376. PubMed  Europe PubMed DOI  I
    10. 2011
  10. Janke,D., Sommerhoff,C.P. and Schaschke,N.
    The arginine mimicking beta-amino acid beta3hPhe(3-H2N-CH2) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors
    Bioorg Med Chem19, 7236-7243. PubMed  Europe PubMed DOI  I
  11. Liang,G., Choi-Sledeski,Y.M., Poli,G.B., Chen,X., Minnich,A., Wang,Q., Tsay,J., Sides,K. and Vaz,R.J.
    Structure-based design, synthesis, and profiling of a beta-tryptase inhibitor with a spiro-piperidineamide scaffold, benzylamine P1 group, and a substituted indole P4 group
    MedChemComm2, 794-799. DOI  I
    12. 2010
  12. Liang,G., Choi-Sledeski,Y.M., Poli,G., Chen,X., Shum,P., Minnich,A., Wang,Q., Tsay,J., Sides,K., Cairns,J., Stoklosa,G., Nieduzak,T., Zhao,Z., Wang,J. and Vaz,R.J.
    A conformationally constrained inhibitor with an enhanced potency for beta-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO)
    Bioorg Med Chem Lett20, 6721-6724. PubMed  Europe PubMed DOI  I
  13. Wich,P.R. and Schmuck,C.
    Reversible and noncompetitive inhibition of beta-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library
    Angew Chem Int Ed Engl49, 4113-4116. PubMed  Europe PubMed DOI  I
    14. 2006
  14. [YEAR:16-5-2006]McGrath,M.E., Sprengeler,P.A., Hirschbein,B., Somoza,J.R., Lehoux,I., Janc,J.W., Gjerstad,E., Graupe,M., Estiarte,A., Venkataramani,C., Liu,Y., Yee,R., Ho,J.D., Green,M.J., Lee,C.S., Liu,L., Tai,V., Spencer,J., Sperandio,D. and Katz,B.A.
    Structure-guided design of peptide-based tryptase inhibitors
    Biochemistry45, 5964-5973. PubMed  Europe PubMed DOI  I
  15. [YEAR:13-3-2006]Miyazaki,Y., Kato,Y., Manabe,T., Shimada,H., Mizuno,M., Egusa,T., Ohkouchi,M., Shiromizu,I., Matsusue,T. and Yamamoto,I.
    Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors
    Bioorg Med Chem Lett16, 2986-2990. PubMed  Europe PubMed DOI  I
  16. [YEAR:28-12-2006]Rohr,K.B., Selwood,T., Marquardt,U., Huber,R., Schechter,N.M., Bode,W. and Than,M.E.
    X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha - >beta-tryptase transition
    J Mol Biol357, 195-209. PubMed  Europe PubMed DOI  S  I
  17. [YEAR:23-5-2006]Sperandio,D., Tai,V.W., Lohman,J., Hirschbein,B., Mendonca,R., Lee,C.S., Spencer,J.R., Janc,J., Nguyen,M., Beltman,J., Sprengeler,P., Scheerens,H., Lin,T., Liu,L., Gadre,A., Kellogg,A., Green,M.J. and McGrath,M.E.
    Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors
    Bioorg Med Chem Lett16, 4085-4089. PubMed  Europe PubMed DOI  I
    18. 2005
  18. [YEAR:15-4-2005]Levell,J., Astles,P., Eastwood,P., Cairns,J., Houille,O., Aldous,S., Merriman,G., Whiteley,B., Pribish,J., Czekaj,M., Liang,G., Maignan,S., Guilloteau,J.P., Dupuy,A., Davidson,J., Harrison,T., Morley,A., Watson,S., Fenton,G., McCarthy,C., Romano,J., Mathew,R., Engers,D., Gardyan,M., Sides,K., Kwong,J., Tsay,J., Rebello,S., Shen,L., Wang,J., Luo,Y., Giardino,O., Lim,H.K., Smith,K. and Pauls,H.
    Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase
    Bioorg Med Chem13, 2859-2872. PubMed  Europe PubMed DOI  I
    19. 2004
  19. [YEAR:20-12-2004]Vaz,R.J., Gao,Z., Pribish,J., Chen,X., Levell,J., Davis,L., Albert,E., Brollo,M., Ugolini,A., Cramer,D.M., Cairns,J., Sides,K., Liu,F., Kwong,J., Kang,J., Rebello,S., Elliot,M., Lim,H., Chellaraj,V., Singleton,R.W. and Li,Y.
    Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase
    Bioorg Med Chem Lett14, 6053-6056. PubMed  Europe PubMed DOI  I
    20. 2003
  20. Selwood,T., Elrod,K.C. and Schechter,N.M.
    Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor
    Biol Chem384, 1605-1611. PubMed  Europe PubMed DOI  I
    21. 2002
  21. Tremaine,W.J., Brzezinski,A., Katz,J.A., Wolf,D.C., Fleming,T.J., Mordenti,J., Strenkoski-Nix,L.C. and Kurth,M.C.
    Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study
    Aliment Pharmacol Ther16, 407-413. PubMed  Europe PubMed DOI  I
    22. 1996
  22. Molinari,J.F., Scuri,M., Moore,W.R., Clark,J., Tanaka,R. and Abraham,W.M.
    Inhaled tryptase causes bronchoconstriction in sheep via histamine release
    Am J Respir Crit Care Med154, 649-653. PubMed  Europe PubMed DOI  I
    23. 1995
  23. Molinari,J.F., Moore,W.R., Clark,J., Tanaka,R., Butterfield,J.H. and Abraham,W.M.
    Role of tryptase in immediate cutaneous responses in allergic sheep
    J Appl Physiol79, 1966-1970. PubMed  Europe PubMed  I

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