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Literature for peptidase M01.011: cystinyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

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    2024
  1. Mpakali,A., Barla,I., Lu,L., Ramesh,K.M., Thomaidis,N., Stern,L.J., Giastas,P. and Stratikos,E.
    Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase
    J Mol Biol436, 168449-168449. PubMed  Europe PubMed DOI  I
    2. 2020
  2. Mpakali,A., Saridakis,E., Giastas,P., Maben,Z., Stern,L.J., Larhed,M., Hallberg,M. and Stratikos,E.
    Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor
    ACS Med Chem Lett11, 1429-1434. PubMed  Europe PubMed DOI  I
    3. 2018
  3. Vanga,S.R., Savmarker,J., Ng,L., Larhed,M., Hallberg,M., Aqvist,J., Hallberg,A., Chai,S.Y. and Gutierrez-de-Teran,H.
    Structural basis of inhibition of human insulin-regulated aminopeptidase (IRAP) by aryl sulfonamides
    ACS Omega3, 4509-4521. PubMed  Europe PubMed DOI  I
    4. 2017
  4. Albiston,A.L., Cacador,M., Sinnayah,P., Burns,P. and Chai,S.Y.
    Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats
    J Mol Endocrinol58, 193-198. PubMed  Europe PubMed DOI  I
  5. El-Hawli,A., Qaradakhi,T., Hayes,A., Rybalka,E., Smith,R., Caprnda,M., Opatrilova,R., Gazdikova,K., Benckova,M., Kruzliak,P. and Zulli,A.
    IRAP inhibition using HFI419 prevents moderate to severe acetylcholine mediated vasoconstriction in a rabbit model
    Biomed Pharmacother86, 23-26. PubMed  Europe PubMed DOI  I
  6. Mpakali,A., Saridakis,E., Harlos,K., Zhao,Y., Kokkala,P., Georgiadis,D., Giastas,P., Papakyriakou,A. and Stratikos,E.
    Ligand-induced conformational change of insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity
    J Med Chem60, 2963-2972. PubMed  Europe PubMed DOI  S  I
    7. 2016
  7. Diwakarla,S., Nylander,E., Gronbladh,A., Vanga,S.R., Khan,Y.S., Gutierrez-de-Teran,H., Savmarker,J., Ng,L., Pham,V., Lundback,T., Jenmalm-Jensen,A., Svensson,R., Artursson,P., Zelleroth,S., Engen,K., Rosenstrom,U., Larhed,M., Aqvist,J., Chai,S.Y. and Hallberg,M.
    Aryl sulfonamide inhibitors of insulin-regulated aminopeptidase enhance spine density in primary hippocampal neuron cultures
    ACS Chem Neurosci7, 1383-1392. PubMed  Europe PubMed DOI  I
  8. Diwakarla,S., Nylander,E., Gronbladh,A., Vanga,S.R., Khan,Y.S., Gutierrez-de-Teran,H., Ng,L., Pham,V., Savmarker,J., Lundback,T., Jenmalm-Jensen,A., Andersson,H., Engen,K., Rosenstrom,U., Larhed,M., Aqvist,J., Chai,S.Y. and Hallberg,M.
    Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density
    Mol Pharmacol89, 413-424. PubMed  Europe PubMed DOI  I
  9. Engen,K., Rosenstrom,U., Axelsson,H., Konda,V., Dahllund,L., Otrocka,M., Sigmundsson,K., Nikolaou,A., Vauquelin,G., Hallberg,M., Jenmalm Jensen,A., Lundback,T. and Larhed,M.
    Identification of drug-like inhibitors of insulin-regulated aminopeptidase through small-molecule screening
    Assay Drug Dev Technol14, 180-193. PubMed  Europe PubMed DOI  I
    10. 2015
  10. Mpakali,A., Saridakis,E., Harlos,K., Zhao,Y., Papakyriakou,A., Kokkala,P., Georgiadis,D. and Stratikos,E.
    Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing
    J Immunol195, 2842-2851. PubMed  Europe PubMed DOI  S  I
  11. Svensson,F., Engen,K., Lundback,T., Larhed,M. and Skold,C.
    Virtual screening for transition state analogue inhibitors of IRAP based on quantum mechanically derived reaction coordinates
    J Chem Inf Model55, 1984-1993. PubMed  Europe PubMed DOI  I
    12. 2014
  12. Borhade,S.R., Rosenstrom,U., Savmarker,J., Lundback,T., Jenmalm-Jensen,A., Sigmundsson,K., Axelsson,H., Svensson,F., Konda,V., Skold,C., Larhed,M. and Hallberg,M.
    Inhibition of insulin-regulated aminopeptidase (IRAP) by arylsulfonamides
    ChemistryOpen3, 256-263. PubMed  Europe PubMed DOI  I
  13. Mountford,S.J., Albiston,A.L., Charman,W.N., Ng,L., Holien,J.K., Parker,M.W., Nicolazzo,J.A., Thompson,P.E. and Chai,S.Y.
    Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase
    J Med Chem57, 1368-1377. PubMed  Europe PubMed DOI  I
    14. 2013
  14. Loyens,E., De Bundel,D., Demaegdt,H., Chai,S.Y., Vanderheyden,P., Michotte,Y., Gard,P. and Smolders,I.
    Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase
    Int J Neuropsychopharmacol16, 1153-1163. PubMed  Europe PubMed DOI  K  I
  15. Nikolaou,A., Eynde,I.V., Tourwe,D., Vauquelin,G., Toth,G., Mallareddy,J.R., Poglitsch,M., Van Ginderachter,J.A. and Vanderheyden,P.M.
    [3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase
    Eur J Pharmacol702, 93-102. PubMed  Europe PubMed DOI  I
    16. 2012
  16. Andersson,H. and Hallberg,M.
    Discovery of inhibitors of insulin-regulated aminopeptidase as cognitive enhancers
    Int J Hypertens2012, 789671-789671. PubMed  Europe PubMed DOI  I
  17. Demaegdt,H., De Backer,J.P., Lukaszuk,A., Toth,G., Szemenyei,E., Tourwe,D. and Vauquelin,G.
    Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP)
    Fundam Clin Pharmacol26, 194-197. PubMed  Europe PubMed DOI  I
    18. 2011
  18. Albiston,A.L., Diwakarla,S., Fernando,R.N., Mountford,S.J., Yeatman,H.R., Morgan,B., Pham,V., Holien,J.K., Parker,M.W., Thompson,P.E. and Chai,S.Y.
    Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers
    Br J Pharmacol164, 37-47. PubMed  Europe PubMed DOI  I
  19. Andersson,H., Demaegdt,H., Johnsson,A., Vauquelin,G., Lindeberg,G., Hallberg,M., Erdelyi,M., Karlen,A. and Hallberg,A.
    Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis
    J Med Chem54, 3779-3792. PubMed  Europe PubMed DOI  I
  20. Demaegdt,H., Gard,P., De Backer,J.P., Lukaszuk,A., Szemenyei,E., Toth,G., Tourwe,D. and Vauquelin,G.
    Binding of "AT4 receptor" ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells
    Mol Cell Endocrinol339, 34-44. PubMed  Europe PubMed DOI  I
    21. 2010
  21. Albiston,A.L., Fernando,R.N., Yeatman,H.R., Burns,P., Ng,L., Daswani,D., Diwakarla,S., Pham,V. and Chai,S.Y.
    Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory
    Neurobiol Learn Mem93, 19-30. PubMed  Europe PubMed DOI  K  I
  22. Andersson,H., Demaegdt,H., Vauquelin,G., Lindeberg,G., Karlen,A., Hallberg,M., Erdelyi,M. and Hallberg,A.
    Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)
    J Med Chem53, 8059-8071. PubMed  Europe PubMed DOI  I
  23. Beyer,C.E., Dwyer,J.M., Platt,B.J., Neal,S., Luo,B., Ling,H.P., Lin,Q., Mark,R.J., Rosenzweig-Lipson,S. and Schechter,L.E.
    Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation
    Psychopharmacology (Berl)209, 303-311. PubMed  Europe PubMed DOI  I
    24. 2009
  24. Demaegdt,H., Lukaszuk,A., De Buyser,E., De Backer,J.P., Szemenyei,E., Toth,G., Chakravarthy,S., Panicker,M., Michotte,Y., Tourwe,D. and Vauquelin,G.
    Selective labeling of IRAP by the tritiated AT(4) receptor ligand [3H]angiotensin IV and its stable analog [3H]AL-11
    Mol Cell Endocrinol311, 77-86. PubMed  Europe PubMed DOI  I
    25. 2008
  25. Albiston,A.L., Morton,C.J., Ng,H.L., Pham,V., Yeatman,H.R., Ye,S., Fernando,R.N., De Bundel,D., Ascher,D.B., Mendelsohn,F.A., Parker,M.W. and Chai,S.Y.
    Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
    FASEB J22, 4209-4217. PubMed  Europe PubMed DOI  T  I
  26. Chai,S.Y., Yeatman,H.R., Parker,M.W., Ascher,D.B., Thompson,P.E., Mulvey,H.T. and Albiston,A.L.
    Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase
    BMC Neurosci9 Suppl 2, S14-S14. PubMed  Europe PubMed DOI  T  I
  27. Cohen,M., Wuillemin,C., Chai,S.Y. and Bischof,P.
    Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion
    J Pept Sci14, 883-887. PubMed  Europe PubMed DOI  I
  28. Demaegdt,H., Smitz,L., De Backer,J.P., Le,M.T., Bauwens,M., Szemenyei,E., Toth,G., Michotte,Y., Vanderheyden,P. and Vauquelin,G.
    Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding
    Br J Pharmacol154, 872-881. PubMed  Europe PubMed DOI  I
  29. Fernando,R.N., Albiston,A.L. and Chai,S.Y.
    The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus - potential role in modulation of glucose uptake in neurones?
    Eur J Neurosci28, 588-598. PubMed  Europe PubMed DOI  I
  30. Stragier,B., De Bundel,D., Sarre,S., Smolders,I., Vauquelin,G., Dupont,A., Michotte,Y. and Vanderheyden,P.
    Involvement of insulin-regulated aminopeptidase in the effects of the renin-angiotensin fragment angiotensin IV: a review
    Heart Fail Rev13, 321-337. PubMed  Europe PubMed DOI  V  I
  31. Ye,S., Chai,S.Y., Lew,R.A., Ascher,D.B., Morton,C.J., Parker,M.W. and Albiston,A.L.
    Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase
    Biochem Cell Biol86, 251-261. PubMed  Europe PubMed DOI  P  I
    32. 2007
  32. Fernando,R.N., Luff,S.E., Albiston,A.L. and Chai,S.Y.
    Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons
    J Neurochem102, 967-976. PubMed  Europe PubMed DOI  I
  33. Stragier,B., Demaegdt,H., De Bundel,D., Smolders,I., Sarre,S., Vauquelin,G., Ebinger,G., Michotte,Y. and Vanderheyden,P.
    Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat
    Brain Res1131, 97-105. PubMed  Europe PubMed DOI  I
  34. Ye,S., Chai,S.Y., Lew,R.A. and Albiston,A.L.
    Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain
    Biol Chem388, 399-403. PubMed  Europe PubMed DOI  I
    35. 2004
  35. [YEAR:1-10-2004]Demaegdt,H., Laeremans,H., De Backer,J.P., Mosselmans,S., Le,M.T., Kersemans,V., Michotte,Y., Vauquelin,G. and Vanderheyden,P.M.
    Synergistic modulation of cystinyl aminopeptidase by divalent cation chelators
    Biochem Pharmacol68, 893-900. PubMed  Europe PubMed DOI  I
  36. [YEAR:1-10-2004]Demaegdt,H., Vanderheyden,P., De Backer,J.P., Mosselmans,S., Laeremans,H., Le,M.T., Kersemans,V., Michotte,Y. and Vauquelin,G.
    Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells: characterization by [125I]Ang IV binding and catalytic activity
    Biochem Pharmacol68, 885-892. PubMed  Europe PubMed DOI  I
  37. [YEAR:20-2-2004]Ito,N., Nomura,S., Iwase,A., Ito,T., Kikkawa,F., Tsujimoto,M., Ishiura,S. and Mizutani,S.
    ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase
    Biochem Biophys Res Commun314, 1008-1013. PubMed  Europe PubMed DOI  I
    38. 2003
  38. Lew,R.A., Mustafa,T., Ye,S., McDowall,S.G., Chai,S.Y. and Albiston,A.L.
    Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)
    J Neurochem86, 344-350. PubMed  Europe PubMed DOI  I
    39. 2001
  39. [YEAR:28-12-2001]Albiston,A.L., McDowall,S.G., Matsacos,D., Sim,P., Clune,E., Mustafa,T., Lee,J., Mendelsohn,F.A., Simpson,R.J., Connolly,L.M. and Chai,S.Y.
    Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase
    J Biol Chem276, 48623-48626. PubMed  Europe PubMed DOI  I

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