$VAR1 = undef;

Summary for peptidase S21.002: cytomegalovirus assemblin

Names
MEROPS Name	cytomegalovirus assemblin
Other names	CMV protease, protease No, UL80 g.p. (human cytomegalovirus)

Domain architecture

MEROPS Classification
Classification	Clan SH >> Subclan (none) >> Family S21 >> Subfamily (none) >> S21.002
Holotype	cytomegalovirus assemblin (human herpesvirus 5), Uniprot accession P16753 (peptidase unit: 1-256), MERNUM MER0000613
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00387
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (5 cleavages)
Physiology	Plays essential role in assembly of herpes virions by digesting scaffold protein.
Pharmaceutical relevance	Potential target for antiviral drug.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	vyl/V/nk/AS/-/sr/plv (based on 13 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	1	0	0
Pro	0	0	0	0	0	0	0	4
Ala	1	0	0	13	2	1	0	0
Val	3	12	0	0	0	3	0	1
Leu	2	0	0	0	0	0	0	3
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	0	0	0	0	0	0
Tyr	3	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	11	1	5	0
Thr	0	0	0	0	0	1	0	0
Cys	0	0	0	0	0	2	0	0
Asn	0	0	5	0	0	0	0	0
Gln	0	0	1	0	0	0	0	0
Asp	1	0	1	0	0	0	1	0
Glu	0	0	1	0	0	0	1	0
Lys	0	0	3	0	0	0	0	0
Arg	0	0	0	0	0	0	4	0
His	0	0	0	0	0	0	0	0