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Literature for peptidase S21.002: cytomegalovirus assemblin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2013
  1. Sabit,H., Dahan,A., Sun,J., Provoda,C.J., Lee,K.D., Hilfinger,J.H. and Amidon,G.L.
    Cytomegalovirus protease targeted prodrug development
    Mol Pharm10, 1417-1424. PubMed  Europe PubMed DOI
    2. 2012
  2. Gibson,W.
    Cytomegalovirus assemblin and precursor
    [ISSN:978-0-12-407742-3]3, 3540-3545. DOI
    3. 2011
  3. Fernandes,S.M., Brignole,E.J., Taori,K. and Gibson,W.
    Cytomegalovirus capsid protease: biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin)
    J Virol85, 3526-3534. PubMed  Europe PubMed DOI
    4. 2009
  4. Kawai,S.H., Aubry,N., Duceppe,J.S., Llinas-Brunet,M. and LaPlante,S.R.
    Dimethylthiazolidine carboxylic acid as a rigid P3 unit in inhibitors of serine proteases: application to two targets
    Chem Biol Drug Des74, 517-522. PubMed  Europe PubMed DOI  I
    5. 2007
  5. Brignole,E.J. and Gibson,W.
    Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain
    J Virol81, 4091-4103. PubMed  Europe PubMed DOI
  6. De Oliveira,C.A.F., Guimaraes,C.R.W., Barreiro,G. and de Alencastro,R.B.
    Human cytomegalovirus protease: why is the dimer required for catalytic activity?
    J Chem Theory Comput3, 278-288. PubMed  Europe PubMed DOI
    7. 2005
  7. [YEAR:7-4-2005]Gerona-Navarro,G., Perez de Vega,M.J., Garcia-Lopez,M.T., Andrei,G., Snoeck,R., De Clercq,E., Balzarini,J. and Gonzalez-Muniz,R.
    From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors
    J Med Chem48, 2612-2621. PubMed  Europe PubMed DOI  I
  8. Loveland,A.N., Chan,C.K., Brignole,E.J. and Gibson,W.
    Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity
    J Virol79, 12961-12968. PubMed  Europe PubMed DOI
  9. [YEAR:21-7-2005]McCartney,S.A., Brignole,E.J., Kolegraff,K.N., Loveland,A.N., Ussin,L.M. and Gibson,W.
    Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a
    J Biol Chem280, 33206-33212. PubMed  Europe PubMed DOI
    10. 2004
  10. Kan,C.C.
    Cytomegalovirus assemblin
    [ISSN:0-12-079610-4]2, 2006-2009.  V
  11. [YEAR:20-1-2004]Khayat,R., Batra,R., Bebernitz,G.A., Olson,M.W. and Tong,L.
    Characterization of the monomer-dimer equilibrium of human cytomegalovirus protease by kinetic methods
    Biochemistry43, 316-322. PubMed  Europe PubMed DOI
  12. Kim,K., Umamoto,S., Trang,P., Hai,R. and Liu,F.
    Intracellular expression of engineered RNase P ribozymes effectively blocks gene expression and replication of human cytomegalovirus
    RNA10, 438-447. PubMed  Europe PubMed DOI
    13. 2003
  13. [YEAR:9-10-2003]Borthwick,A.D., Davies,D.E., Ertl,P.F., Exall,A.M., Haley,T.M., Hart,G.J., Jackson,D.L., Parry,N.R., Patikis,A., Trivedi,N., Weingarten,G.G. and Woolven,J.M.
    Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability
    J Med Chem46, 4428-4449. PubMed  Europe PubMed DOI  I
  14. [YEAR:1-9-2003]de Oliveira,C.A., Guimaraes,C.R., Barreiro,G. and de Alencastro,R.B.
    Investigation of the induced-fit mechanism and catalytic activity of the human cytomegalovirus protease homodimer via molecular dynamics simulations
    Proteins52, 483-491. PubMed  Europe PubMed DOI
  15. [YEAR:4-2-2003]Khayat,R., Batra,R., Qian,C., Halmos,T., Bailey,M. and Tong,L.
    Structural and biochemical studies of inhibitor binding to human cytomegalovirus protease
    Biochemistry42, 885-891. PubMed  Europe PubMed DOI  S  I
  16. [YEAR:16-5-2003]Trang,P., Kim,K., Zhu,J. and Liu,F.
    Expression of an RNase P ribozyme against the mRNA encoding human cytomegalovirus protease inhibits viral capsid protein processing and growth
    J Mol Biol328, 1123-1135. PubMed  Europe PubMed DOI
    17. 2002
  17. [YEAR:3-1-2002]Borthwick,A.D., Crame,A.J., Ertl,P.F., Exall,A.M., Haley,T.M., Hart,G.J., Mason,A.M., Pennell,A.M., Singh,O.M., Weingarten,G.G. and Woolven,J.M.
    Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality
    J Med Chem45, 1-18. PubMed  Europe PubMed DOI  I
  18. Chan,C.K., Brignole,E.J. and Gibson,W.
    Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions
    J Virol76, 8667-8674. PubMed  Europe PubMed DOI
  19. Wittwer,A.J., Funckes-Shippy,C.L. and Hippenmeyer,P.J.
    Recombinant full-length human cytomegalovirus protease has lower activity than recombinant processed protease domain in purified enzyme and cell-based assays
    Antiviral Res55, 291-306. PubMed  Europe PubMed DOI
    20. 2001
  20. Batra,R., Khayat,R. and Tong,L.
    Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease
    Nat Struct Biol8, 810-817. PubMed  Europe PubMed DOI
  21. [YEAR:29-5-2001]Khayat,R., Batra,R., Massariol,M.J., Lagace,L. and Tong,L.
    Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease
    Biochemistry40, 6344-6351. PubMed  Europe PubMed DOI
    22. 2000
  22. [YEAR:16-11-2000]Borthwick,A.D., Angier,S.J., Crame,A.J., Exall,A.M., Haley,T.M., Hart,G.J., Mason,A.M., Pennell,A.M. and Weingarten,G.G.
    Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template
    J Med Chem43, 4452-4464. PubMed  Europe PubMed DOI  I
  23. Waxman,L. and Darke,P.L.
    The herpesvirus proteases as targets for antiviral chemotherapy
    Antivir Chem Chemother11, 1-22. PubMed  Europe PubMed
    24. 1999
  24. [YEAR:7-4-1999]Bonneau,P.R., Hasani,F., Plouffe,C., Malenfant,E., LaPlante,S.R., Guse,I., Ogilvie,W.W., Plante,R., Davidson,W.C., Hopkins,J.L., Morelock,M.M., Cordingley,M.G. and Deziel,R.
    Inhibition of human cytomegalovirus protease by monocyclic beta-lactam derivatives: kinetic characterization using a fluorescent probe
    J Am Chem Soc121, 2965-2973. DOI  A  I
  25. [YEAR:4-10-1999]Ertl,P., Cooper,D., Allen,G. and Slater,M.J.
    2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease
    Bioorg Med Chem Lett9, 2863-2866. PubMed  Europe PubMed DOI
  26. [YEAR:7-6-1999]Holwerda,B.
    Activity in monomers of human cytomegalovirus protease
    Biochem Biophys Res Commun259, 370-373. PubMed  Europe PubMed DOI
  27. [YEAR:7-4-1999]LaPlante,S.R., Bonneau,P.R., Aubry,N., Cameron,D.R., Deziel,R., Grand-Maitre,E., Plouffe,C., Tong,L. and Kawai,S.H.
    Characterization of the human cytomegalovirus protease as an induced-fit serine protease and the implications to the design of mechanism-based inhibitors
    J Am Chem Soc121, 2974-2986. DOI  I
  28. [YEAR:10-4-1999]Lawler,J.F., Jr. and Snyder,S.H.
    Viral protease assay based on GAL4 inactivation is applicable to high-throughput screening in mammalian cells
    Anal Biochem269, 133-138. PubMed  Europe PubMed DOI  A
  29. Ogilvie,W.W., Yoakim,C., Do,F., Hache,B., Lagace,L., Naud,J., O'Meara,J.A. and Deziel,R.
    Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease
    Bioorg Med Chem7, 1521-1531. PubMed  Europe PubMed DOI  I
  30. [YEAR:8-2-1999]Pinto,I.L., Jarvest,R.L., Clarke,B., Dabrowski,C.E., Fenwick,A., Gorczyca,M.M., Jennings,L.J., Lavery,P., Sternberg,E.J., Tew,D.G. and West,A.
    Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism
    Bioorg Med Chem Lett9, 449-452. PubMed  Europe PubMed DOI  I
  31. [YEAR:1-11-1999]Smith,D.G., Gribble,A.D., Haigh,D., Ife,R.J., Lavery,P., Skett,P., Slingsby,B.P., Stacey,R., Ward,R.W. and West,A.
    The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives
    Bioorg Med Chem Lett9, 3137-3142. PubMed  Europe PubMed DOI
    32. 1998
  32. [YEAR:1-1-1998]Bonneau,P.R., Plouffe,C., Pelletier,A., Wernic,D. and Poupart,M.A.
    Design of fluorogenic peptide substrates for human cytomegalovirus protease based on structure-activity relationship studies
    Anal Biochem255, 59-65. PubMed  Europe PubMed DOI
  33. LaPlante,S.R., Cameron,D.R., Aubry,N., Bonneau,P.R., Deziel,R., Grand-Maitre,C., Ogilvie,W.W. and Kawai,S.H.
    The conformation of a peptidyl methyl ketone inhibitor bound to the human cytomegalovirus protease
    Angew Chem Int Ed Engl37, 2729-2732. PubMed  Europe PubMed DOI  S  I
  34. [YEAR:7-7-1998]LaPlante,S.R., Aubry,N., Bonneau,P.R., Cameron,D.R., Lagace,L., Massariol,M.J., Montpetit,H., Plouffe,C., Kawai,S.H., Fulton,B.D., Chen,Z. and Ni,F.
    Human cytomegalovirus protease complexes its substrate recognition sequences in an extended peptide conformation
    Biochemistry37, 9793-9801. PubMed  Europe PubMed DOI
  35. [YEAR:28-4-1998]Liang,P.H., Brun,K.A., Feild,J.A., O'Donnell,K., Doyle,M.L., Green,S.M., Baker,A.E., Blackburn,M.N. and Abdel-Meguid,S.S.
    Site-directed mutagenesis probing the catalytic role of arginines 165 and 166 of human cytomegalovirus protease
    Biochemistry37, 5923-5929. PubMed  Europe PubMed DOI
  36. Plafker,S.M. and Gibson,W.
    Cytomegalovirus assembly protein precursor and proteinase precursor contain two nuclear localization signals that mediate their own nuclear translocation and that of the major capsid protein
    J Virol72, 7722-7732. PubMed  Europe PubMed
  37. Tong,L., Qian,C., Massariol,M.J., Deziel,R., Yoakim,C. and Lagace,L.
    Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease
    Nat Struct Biol5, 819-826. PubMed  Europe PubMed DOI  S
    38. 1997
  38. [YEAR:14-11-1997]Babe,L.M. and Craik,C.S.
    Viral proteases: evolution of diverse structural motifs to optimize function
    Cell91, 427-430. PubMed  Europe PubMed
  39. Bonneau,P.R., Grand-Maitre,C., Greenwood,D.J., Lagace,L., LaPlante,S.R., Massariol,M.J., Ogilvie,W.W., O'Meara,J.A. and Kawai,S.H.
    Evidence of a conformational change in the human cytomegalovirus protease upon binding of peptidyl-activated carbonyl inhibitors
    Biochemistry36, 12644-12652. PubMed  Europe PubMed DOI  I
  40. Hesson,T., Tsarbopoulos,A., Shane Taremi,S., Prosise,W.W., Butkiewicz,N., Dasmahapatra,B., Cable,M., Van Le,H. and Weber,P.C.
    Inactivation of the human cytomegalovirus protease by diisopropylfluorophosphate
    Tech Protein Chem8, 257-266. DOI  I
  41. Huffaker,T.K., Binford,S., Patick,A.K., Pinko,C., Kan,C.C. and Zalman,L.S.
    Comparison of human cytomegalovirus (HCMV) protease sequences among laboratory strains and seven clinical isolates
    Antiviral Res33, 215-218. PubMed  Europe PubMed DOI
  42. Jarvest,R.L., Connor,S.C., Gorniak,J.G., Jennings,L.J., Serafinowska,H.T. and West,A.
    Potent selective thienoxazinone inhibitors of herpes proteases
    Bioorg Med Chem Lett7, 1733-1738.  I
  43. Levine,L.M., Michener,M.L., Toth,M.V. and Holwerda,B.C.
    Measurement of specific protease activity utilizing fluorescence polarization
    Anal Biochem247, 83-88. PubMed  Europe PubMed DOI  A
  44. Tong,L., Qian,C., Davidson,W., Massariol,M.J., Bonneau,P.R., Cordingley,M.G. and Lagace,L.
    Experiences from the structure determination of human cytomegalovirus protease
    Acta Crystallogr D Biol Crystallogr53, 682-690. PubMed  Europe PubMed DOI
    45. 1996
  45. Baum,E.Z., Johnston,S.H., Bebernitz,G.A. and Gluzman,Y.
    Development of a scintillation proximity assay for human cytomegalovirus protease using 33phosphorous
    Anal Biochem237, 129-134. PubMed  Europe PubMed DOI  A
  46. Chen,P., Tsuge,H., Almassy,R.J., Gribskov,C.L., Katoh,S., Vanderpool,D.L., Margosiak,S.A., Pinko,C., Matthews,D.A. and Kan,C.C.
    Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad
    Cell86, 835-843. PubMed  Europe PubMed DOI  S
  47. Darke,P.L., Cole,J.L., Waxman,L., Hall,D.L., Sardana,M.K. and Kuo,L.C.
    Active human cytomegalovirus protease is a dimer
    J Biol Chem271, 7445-7449. PubMed  Europe PubMed DOI
  48. Qiu,X., Culp,J.S., DiLella,A.G., Hellmig,B., Hoog,S.S., Janson,C.A., Smith,W.W. and Abdel-Meguid,S.S.
    Unique fold and active site in cytomegalovirus protease
    Nature383, 275-279. PubMed  Europe PubMed DOI  S
  49. Shieh,H.S., Kurumbail,R.G., Stevens,A.M., Stegeman,R.A., Sturman,E.J., Pak,J.Y., Wittwer,A.J., Palmier,M.O., Wiegand,R.C., Holwerda,B.C. and Stallings,W.C.
    Three-dimensional structure of human cytomegalovirus protease
    Nature383, 279-282. PubMed  Europe PubMed DOI  S
  50. Tong,L., Qian,C., Massariol,M.J., Bonneau,P.R., Cordingley,M.G. and Lagace,L.
    A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease
    Nature383, 272-275. PubMed  Europe PubMed DOI  S
    51. 1995
  51. Handa,B.K., Keech,E., Conway,E.A., Broadhurst,A. and Ritchie,A.
    Design and synthesis of a quenched flourogenic peptide substrate for human cytomegalovirus proteinase
    Antiviral Chem Chemother6, 255-261.
  52. Holskin,B.P., Bukhtiyarova,M., Dunn,B.M., Baur,P., de Chastonay,J. and Pennington,M.W.
    A continuous fluorescence-based assay of human cytomegalovirus protease using a peptide substrate
    Anal Biochem227, 148-155. PubMed  Europe PubMed DOI  A  E
  53. Roizman,B. and Sears,A.
    Herpes simplex viruses and their replication
    3, 2231-2295.
    54. 1994
  54. Jones,T.R., Sun,L., Bebernitz,G.A., Muzithras,V.P., Kim,H.J., Johnston,S.H. and Baum,E.Z.
    Proteolytic activity of human cytomegalovirus UL80 protease cleavage site mutants
    J Virol68, 3742-3752. PubMed  Europe PubMed
  55. Loutsch,J.M., Galvin,N.J., Bryant,M.L. and Holwerda,B.C.
    Cloning and sequence analysis of murine cytomegalovirus protease and capsid assembly protein genes
    Biochem Biophys Res Commun203, 472-478. PubMed  Europe PubMed DOI
  56. [YEAR:20-5-1994]Sardana,V.V., Wolfgang,J.A., Veloski,C.A., Long,W.J., LeGrow,K., Wolanski,B., Emini,E.A. and LaFemina,R.L.
    Peptide substrate cleavage specificity of the human cytomegalovirus protease
    J Biol Chem269, 14337-14340. PubMed  Europe PubMed
  57. Smith,M.C., Giordano,J., Cook,J.A., Wakulchik,M., Villarreal,E.C., Becker,G.W., Bemis,K., Labus,J. and Manetta,J.S.
    Purification and kinetic characterization of human cytomegalovirus assemblin
    Methods Enzymol244, 412-423. PubMed  Europe PubMed DOI  V
    58. 1993
  58. Baum,E.Z., Bebernitz,G.A., Hulmes,J.D., Muzithras,V.P., Jones,T.R. and Gluzman,Y.
    Expression and analysis of the human cytomegalovirus UL80-encoded protease: identification of autoproteolytic sites
    J Virol67, 497-506. PubMed  Europe PubMed

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