Structure for peptidase S21.002: cytomegalovirus assemblin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1LAY human herpesvirus 5 2.50 Å Ala143Val mutant
Catalytic residues are shown in ball-and-stick representation: His63 and His157 in purple, and Ser132 in orange.
This browser does not have a Java Plug-in.
Get the latest Java Plug-in here.
Show surface
TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
human herpesvirus 5
mature  peptidase 2.27 Å 1CMV 1CMV 1CMV 1CMV 1CMV 1CMV Shieh et al., 1996
active site His157Gln mutant 2.20 Å 1ID4 1ID4 1ID4 1ID4 1ID4 1ID4 Khayat et al., 2001
active site His157Ala mutant 2.20 Å 1IEC 1IEC 1IEC 1IEC 1IEC 1IEC Khayat et al., 2001
active site His157Glu mutant 2.00 Å 1IED 1IED 1IED 1IED 1IED 1IED Khayat et al., 2001
active site Ser134Ala mutant 2.30 Å 1IEF 1IEF 1IEF 1IEF 1IEF 1IEF Khayat et al., 2001
active site Ser134Ala/His157Ala double mutant 2.00 Å 1IEG 1IEG 1IEG 1IEG 1IEG 1IEG Khayat et al., 2001
dimer interface Ser225Tyr mutant 2.30 Å 1JQ6 1JQ6 1JQ6 1JQ6 1JQ6 1JQ6 Batra et al., 2001
dimer interface Ser225Tyr mutant; complex with BILC 408 inhibitor 3.00 Å 1JQ7 1JQ7 1JQ7 1JQ7 1JQ7 1JQ7 Batra et al., 2001
Ala143Val mutant 2.50 Å 1LAY 1LAY 1LAY 1LAY 1LAY 1LAY Qiu et al., 1996
complex with N-acetyl-L-valyl-3,3-dimethyl-L-alpha-aspartyl-N~4~,N~4~-dimethyl-N~1~-[(1R)-3,3,3-trifluoro-1-methyl-2-oxopropyl]-L-aspartamide 2.50 Å 1NJT 1NJT 1NJT 1NJT 1NJT 1NJT Khayat et al., 2003
complex with N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl- L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-[(1R)- 1-phenylpropyl]aminobutan-2-yl]-N~4~,N~4~- dimethyl-L-aspartamide 2.70 Å 1NJU 1NJU 1NJU 1NJU 1NJU 1NJU Khayat et al., 2003
complex with N-acetyl-L-valyl-3,3-dimethyl-L-alpha-aspartyl-N~4~,N~4~-dimethyl-N~1~-[(1R)-3,3,3-trifluoro-1-methyl-2-oxopropyl]-L-aspartamide 2.60 Å 1NKK 1NKK 1NKK 1NKK 1NKK 1NKK Khayat et al., 2003
complex with N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~4~,N~4~-dimethyl-N~1~-[(1R)-1-methyl-2,3-dioxo-3-[(1S)-1- phenylpropyl]aminopropyl]-L-aspartamide 2.70 Å 1NKM 1NKM 1NKM 1NKM 1NKM 1NKM Khayat et al., 2003
dimer 2.00 Å 1WPO 1WPO 1WPO 1WPO 1WPO 1WPO Tong et al., 1996
complex with des-amino-t-butyl-Gly-t-butyl-Gly-phenylAsn-Ala-BAC inhibitor 2.70 Å 2WPO 2WPO 2WPO 2WPO 2WPO 2WPO Tong et al., 1998