$VAR1 = undef;

Summary for peptidase S01.224: hepsin

Names
MEROPS Name	hepsin
Other names	HPN g.p. (Homo sapiens), TMPRSS1

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.224
Holotype	hepsin (Homo sapiens), Uniprot accession P05981 (peptidase unit: 163-407), MERNUM MER0000156
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00317
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.106
Enzymology	BRENDA database
Proteolytic events	CutDB database (7 cleavages)
Activity status	human: active (Kurachi & Yamamoto, 2004) mouse: active (by similarity) (Yu et al., 2000)
Physiology	Suggested to play a role in growth of some cells.
Knockout	Mice lacking hepsin are almost normal, and so give little indication of the physiological functions of the enzyme (Wu et al., 1998; Yu et al., 2000).
Pathways	KEGG	Viral carcinogenesis
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/HPN_(gene)
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Rkg/-/-/- (based on 110 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	6	7	6	1	21	10	21	23
Pro	9	2	10	0	0	6	7	4
Ala	3	11	13	1	3	6	10	9
Val	2	6	6	0	15	25	7	4
Leu	5	6	10	2	7	2	11	10
Ile	4	4	4	0	5	8	6	10
Met	3	2	3	0	1	1	1	0
Phe	1	5	2	0	0	5	2	2
Tyr	3	1	3	0	2	1	1	3
Trp	1	0	0	0	1	0	0	0
Ser	10	9	2	0	7	5	13	7
Thr	3	4	7	0	4	4	4	3
Cys	0	1	1	0	2	0	1	0
Asn	3	1	5	0	0	2	2	3
Gln	0	13	11	0	1	15	7	8
Asp	1	0	1	0	0	1	3	5
Glu	1	0	0	0	0	1	1	3
Lys	6	6	8	1	23	7	4	11
Arg	11	7	8	105	11	3	0	0
His	0	0	0	0	3	4	5	1