Literature for peptidase S01.224: hepsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Jin,Z., Zhang,Y., Chen,W., Li,H., Shi,L., Wang,D., Zhu,R. and Zhang,C. Intracellular autoactivation and surface location of hepsin, TMPRSS2, and TMPRSS13 Life Sci (2024) , 123299-123299. PubMed Europe PubMed DOI
Yang,T.H., Hsu,Y.C., Yeh,P., Hung,C.J., Tsai,Y.F., Fang,M.C., Yen,A.C.C., Chen,L.F., Pan,J.Y., Wu,C.C., Liu,T.C., Chung,F.L., Yu,W.M. and Lin,S.W. Critical role of hepsin/TMPRSS1 in hearing and tectorial membrane morphogenesis: Insights from transgenic mouse models Hear Res (2024) 453, 109134-109134. PubMed Europe PubMed DOI PMC EPMC

2023

Bergeron,J.J.M. and Thomas,D.Y. N-glycosylation mediated folding and quality control in serine proteases of the hepsin family FEBS J (2023) 290, 3963-3965. PubMed Europe PubMed DOI
Rodenas,M.C., Penas-Martinez,J., Pardo-Sanchez,I., Zaragoza-Huesca,D., Ortega-Sabater,C., Pena-Garcia,J., Espin,S., Ricote,G., Montenegro,S., Ayala-De La Pena,F., Luengo-Gil,G., Nieto,A., Garcia-Molina,F., Vicente,V., Bernardi,F., Lozano,M.L., Mulero,V., Perez-Sanchez,H., Carmona-Bayonas,A. and Martinez-Martinez,I. Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells Front Mol Biosci (2023) 10, 1182925-1182925. PubMed Europe PubMed DOI PMC EPMC I
Wu,Q., Li,S., Zhang,X. and Dong,N. Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function Biomedicines (2023) 11 PubMed Europe PubMed DOI PMC EPMC V

2022

Knaff,P.M., Muller,P., Kersten,C., Wettstein,L., Munch,J., Landfester,K. and Mailander,V. Structure-Based Design of High-Affinity and Selective Peptidomimetic Hepsin Inhibitors Biomacromolecules (2022) 23, 2236-2242. PubMed Europe PubMed DOI
Lu,L., Cole,A., Huang,D., Wang,Q., Guo,Z., Yang,W. and Lu,J. Clinical Significance of Hepsin and Underlying Signaling Pathways in Prostate Cancer Biomolecules (2022) 12 PubMed Europe PubMed DOI PMC EPMC V

2020

Blay,V., Li,M.C., Ho,S.P., Stoller,M.L., Hsieh,H.P. and Houston,D.R. Design of drug-like hepsin inhibitors against prostate cancer and kidney stones Acta Pharm Sin B (2020) 10, 1309-1320. PubMed Europe PubMed DOI PMC EPMC
Knaff,P.M., Kersten,C., Willbold,R., Champanhac,C., Crespy,D., Wittig,R., Landfester,K. and Mailander,V. From in silico to experimental validation: tailoring peptide substrates for a serine protease Biomacromolecules (2020) 21, 1636-1643. PubMed Europe PubMed DOI A P
Kwon,H., Ha,H., Jeon,H., Jang,J., Son,S.H., Lee,K., Park,S.K. and Byun,Y. Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres Bioorg Chem (2020) , 104521-104521. PubMed Europe PubMed DOI
Li,S., Peng,J., Wang,H., Zhang,W., Brown,J.M., Zhou,Y. and Wu,Q. Hepsin enhances liver metabolism and inhibits adipocyte browning in mice Proc Natl Acad Sci U S A (2020) 117, 12359-12367. PubMed Europe PubMed DOI K
Li,S., Wang,L., Sun,S. and Wu,Q. Hepsin: a multifunctional transmembrane serine protease in pathobiology FEBS J (2020) PubMed Europe PubMed DOI V
Murza,A., Dion,S.P., Boudreault,P.L., Desilets,A., Leduc,R. and Marsault,E. Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract - A review of patent literature Expert Opin Ther Pat (2020) , 1-18. PubMed Europe PubMed DOI
Sun,S., Wang,L., Zhang,S., Zhang,C., Chen,Y., Wu,Q. and Dong,N. N-glycan in the scavenger receptor cysteine-rich domain of hepsin promotes intracellular trafficking and cell surface expression Int J Biol Macromol (2020) 161, 818-827. PubMed Europe PubMed DOI

2019

Damalanka,V.C., Han,Z., Karmakar,P., O'Donoghue,A.J., La Greca,F., Kim,T., Pant,S.M., Helander,J., Klefstrom,J., Craik,C.S. and Janetka,J.W. Discovery of selective matriptase and hepsin serine protease inhibitors: useful chemical tools for cancer cell biology J Med Chem (2019) 62, 480-490. PubMed Europe PubMed DOI I
Damalanka,V.C. and Janetka,J.W. Recent progress on inhibitors of the type II transmembrane serine proteases, hepsin, matriptase and matriptase-2 Future Med Chem (2019) 11, 743-769. PubMed Europe PubMed DOI I
Damalanka,V.C., Wildman,S.A. and Janetka,J.W. Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin MedChemComm (2019) 10, 1646-1655. PubMed Europe PubMed DOI PMC EPMC I
Kim,K., Kwon,H., Choi,D., Lim,T., Minn,I., Son,S.H. and Byun,Y. Design and synthesis of dye-conjugated hepsin inhibitors Bioorg Chem (2019) 89, 102990-102990. PubMed Europe PubMed DOI L I
Olinger,E., Lake,J., Sheehan,S., Schiano,G., Takata,T., Tokonami,N., Debaix,H., Consolato,F., Rampoldi,L., Korstanje,R. and Devuyst,O. Hepsin-mediated processing of uromodulin is crucial for salt-sensitivity and thick ascending limb homeostasis Sci Rep (2019) 9, 12287-12287. PubMed Europe PubMed DOI
Wang,L., Zhang,C., Sun,S., Chen,Y., Hu,Y., Wang,H., Liu,M., Dong,N. and Wu,Q. Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells Biochem J (2019) 476, 2355-2369. PubMed Europe PubMed DOI
Willbold,R., Wirth,K., Martini,T., Sultmann,H., Bolenz,C. and Wittig,R. Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells Cell Death Dis (2019) 10, 601-601. PubMed Europe PubMed DOI PMC EPMC

2018

Pant,S.M., Belitskin,D., Ala-Hongisto,H., Klefstrom,J. and Tervonen,T.A. Analyzing the type II transmembrane serine protease hepsin-dependent basement membrane remodeling in 3D cell culture Methods Mol Biol (2018) 1731, 169-178. PubMed Europe PubMed DOI
Pant,S.M., Mukonoweshuro,A., Desai,B., Ramjee,M.K., Selway,C.N., Tarver,G.J., Wright,A.G., Birchall,K., Chapman,T.M., Tervonen,T.A. and Klefstrom,J. Design, synthesis, and testing of potent, selective hepsin inhibitors via application of an automated closed-loop optimization platform J Med Chem (2018) 61, 4335-4347. PubMed Europe PubMed DOI I

2017

Kwon,H., Han,J., Lee,K.Y., Son,S.H. and Byun,Y. Recent advances of hepsin-targeted inhibitors Curr Med Chem (2017) 24, 2294-2311. PubMed Europe PubMed DOI I
Nassan,M., Jia,Y.F., Jenkins,G., Colby,C., Feeder,S., Choi,D.S., Veldic,M., McElroy,S.L., Bond,D.J., Weinshilboum,R., Biernacka,J.M. and Frye,M.A. Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: applications of a proteomic informed genomic approach J Psychiatr Res (2017) 95, 208-212. PubMed Europe PubMed DOI M
Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D. Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases Am J Cancer Res (2017) 7, 2257-2274. PubMed Europe PubMed PMC EPMC
Tanabe,L.M. and List,K. The role of type II transmembrane serine protease-mediated signaling in cancer FEBS J (2017) 284, 1421-1436. PubMed Europe PubMed DOI I
Wilkinson,D.J., Desilets,A., Lin,H., Charlton,S., Del Carmen Arques,M., Falconer,A., Bullock,C., Hsu,Y.C., Birchall,K., Hawkins,A., Thompson,P., Ferrell,W.R., Lockhart,J., Plevin,R., Zhang,Y., Blain,E., Lin,S.W., Leduc,R., Milner,J.M. and Rowan,A.D. The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover Sci Rep (2017) 7, 16693-16693. PubMed Europe PubMed DOI PMC EPMC
Yogo,T., Umezawa,K., Kamiya,M., Hino,R. and Urano,Y. Development of an activatable fluorescent probe for prostate cancer imaging Bioconjug Chem (2017) 28, 2069-2076. PubMed Europe PubMed DOI L

2016

Han,Z., Harris,P.K., Karmakar,P., Kim,T., Owusu,B.Y., Wildman,S.A., Klampfer,L. and Janetka,J.W. alpha-Ketobenzothiazole serine protease inhibitors of aberrant HGF/c-MET and MSP/RON kinase pathway signaling in cancer ChemMedChem (2016) 11, 585-599. PubMed Europe PubMed DOI I
Kwon,H., Kim,Y., Park,K., Choi,S.A., Son,S.H. and Byun,Y. Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors Bioorg Med Chem Lett (2016) 26, 310-314. PubMed Europe PubMed DOI I
Tervonen,T.A., Belitskin,D., Pant,S.M., Englund,J.I., Marques,E., Ala-Hongisto,H., Nevalaita,L., Sihto,H., Heikkila,P., Leidenius,M., Hewitson,K., Ramachandra,M., Moilanen,A., Joensuu,H., Kovanen,P.E., Poso,A. and Klefstrom,J. Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion Oncogene (2016) 35, 1832-1846. PubMed Europe PubMed DOI
Venukadasula,P.K., Owusu,B.Y., Bansal,N., Ross,L.J., Hobrath,J.V., Bao,D., Truss,J.W., Stackhouse,M., Messick,T.E., Klampfer,L. and Galemmo RA Jr Design and synthesis of nonpeptide inhibitors of hepatocyte growth factor activation ACS Med Chem Lett (2016) 7, 177-181. PubMed Europe PubMed DOI PMC EPMC I
Zhang,M., Gu,J. and Zhang,C. Hepatitis B virus X protein binding to hepsin promotes C3 production by inducing IL-6 secretion from hepatocytes Oncotarget (2016) 7, 7780-7800. PubMed Europe PubMed DOI

2015

Brunati,M., Perucca,S., Han,L., Cattaneo,A., Consolato,F., Andolfo,A., Schaeffer,C., Olinger,E., Peng,J., Santambrogio,S., Perrier,R., Li,S., Bokhove,M., Bachi,A., Hummler,E., Devuyst,O., Wu,Q., Jovine,L. and Rampoldi,L. The serine protease hepsin mediates urinary secretion and polymerisation of zona pellucida domain protein uromodulin elife (2015) 4, e08887- PubMed Europe PubMed DOI
Franco,F.M., Jones,D.E., Harris,P.K., Han,Z., Wildman,S.A., Jarvis,C.M. and Janetka,J.W. Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: evaluation of potency and selectivity derived from distinct binding pockets Bioorg Med Chem (2015) 23, 2328-2343. PubMed Europe PubMed DOI I
Goswami,R., Wohlfahrt,G., Tormakangas,O., Moilanen,A., Lakshminarasimhan,A., Nagaraj,J., Arumugam,K.N., Mukherjee,S., Chacko,A.R., Krishnamurthy,N.R., Jaleel,M., Palakurthy,R.K., Samiulla,D.S. and Ramachandra,M. Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors Bioorg Med Chem Lett (2015) 25, 5309-5314. PubMed Europe PubMed DOI I
Niehaus,J.Z., Miedel,M.T., Good,M., Wyatt,A.N., Pak,S.C., Silverman,G.A. and Luke,C.J. SERPINB12 is a slow-binding inhibitor of granzyme A and hepsin Biochemistry (2015) 54, 6756-6759. PubMed Europe PubMed DOI
Zhang,C., Zhang,M., Wu,Q., Peng,J., Ruan,Y. and Gu,J. Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2alpha phosphorylation in prostate cancer Cell Signal (2015) 27, 789-797. PubMed Europe PubMed DOI

2014

Barre,O., Dufour,A., Eckhard,U., Kappelhoff,R., Beliveau,F., Leduc,R. and Overall,C.M. Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries PLoS ONE (2014) 9, e105984-e105984. PubMed Europe PubMed DOI PMC EPMC P
Han,Z., Harris,P.K., Jones,D.E., Chugani,R., Kim,T., Agarwal,M., Shen,W., Wildman,S.A. and Janetka,J.W. Inhibitors of HGFA, matriptase, and hepsin serine proteases: a nonkinase strategy to block cell signaling in cancer ACS Med Chem Lett (2014) 5, 1219-1224. PubMed Europe PubMed DOI PMC EPMC I
Khandekar,G. and Jagadeeswaran,P. Role of hepsin in factor VII activation in zebrafish Blood Cells Mol Dis (2014) 52, 76-81. PubMed Europe PubMed DOI
Tang,X., Mahajan,S.S., Nguyen,L.T., Beliveau,F., Leduc,R., Simon,J.A. and Vasioukhin,V. Targeted inhibition of cell-surface serine protease hepsin blocks prostate cancer bone metastasis Oncotarget (2014) 5, 1352-1362. PubMed Europe PubMed I
Wang,C., Guo,L., Yu,D., Hua,X., Yang,Z., Yuan,C. and Cui,L. HEV-ORF3 encoding phosphoprotein interacts with hepsin Hepat Mon (2014) 14, e13902-e13902. PubMed Europe PubMed DOI PMC EPMC

2013

Guo,J., Li,G., Tang,J., Cao,X.B., Zhou,Q.Y., Fan,Z.J., Zhu,B. and Pan,X.H. HLA-A2-restricted cytotoxic T lymphocyte epitopes from human hepsin as novel targets for prostate cancer immunotherapy Scand J Immunol (2013) 78, 248-257. PubMed Europe PubMed DOI T

2012

Hsu,Y.C., Huang,H.P., Yu,I.S., Su,K.Y., Lin,S.R., Lin,W.C., Wu,H.L., Shi,G.Y., Tao,M.H., Kao,C.H., Wu,Y.M., Martin,P.E., Lin,S.Y., Yang,P.C. and Lin,S.W. Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice Hepatology (2012) 56, 1913-1923. PubMed Europe PubMed DOI
Koschubs,T., Dengl,S., Durr,H., Kaluza,K., Georges,G., Hartl,C., Jennewein,S., Lanzendorfer,M., Auer,J., Stern,A., Huang,K.S., Packman,K., Gubler,U., Kostrewa,D., Ries,S., Hansen,S., Kohnert,U., Cramer,P. and Mundigl,O. Allosteric antibody inhibition of human hepsin protease Biochem J (2012) 442, 483-494. PubMed Europe PubMed DOI
Wu,Q. and Peng,J. Hepsin [ISSN:978-0-12-407742-3] (2012) 3, 2985-2989. DOI

2011

Antalis,T.M., Bugge,T.H. and Wu,Q. Membrane-anchored serine proteases in health and disease Prog Mol Biol Transl Sci (2011) 99, 1-50. PubMed Europe PubMed DOI V
Ganesan,R., Kolumam,G.A., Lin,S.J., Xie,M.H., Santell,L., Wu,T.D., Lazarus,R.A., Chaudhuri,A. and Kirchhofer,D. Proteolytic activation of pro-macrophage-stimulating protein by hepsin Mol Cancer Res (2011) 9, 1175-1186. PubMed Europe PubMed DOI
Wittig-Blaich,S.M., Kacprzyk,L.A., Eismann,T., Bewerunge-Hudler,M., Kruse,P., Winkler,E., Strauss,W.S., Hibst,R., Steiner,R., Schrader,M., Mertens,D., Sultmann,H. and Wittig,R. Matrix-dependent regulation of AKT in hepsin-overexpressing PC3 prostate cancer cells Neoplasia (2011) 13, 579-589. PubMed Europe PubMed DOI PMC EPMC
Xing,P., Li,J.G., Jin,F., Zhao,T.T., Liu,Q., Dong,H.T. and Wei,X.L. Clinical and biological significance of hepsin overexpression in breast cancer J Investig Med (2011) 59, 803-810. PubMed Europe PubMed DOI T

2010

Camerer,E., Barker,A., Duong,D.N., Ganesan,R., Kataoka,H., Cornelissen,I., Darragh,M.R., Hussain,A., Zheng,Y.W., Srinivasan,Y., Brown,C., Xu,S.M., Regard,J.B., Lin,C.Y., Craik,C.S., Kirchhofer,D. and Coughlin,S.R. Local protease signaling contributes to neural tube closure in the mouse embryo Dev Cell (2010) 18, 25-38. PubMed Europe PubMed DOI PMC EPMC
Chen,M., Chen,L.M., Lin,C.Y. and Chai,K.X. Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor Mol Cell Biochem (2010) 337, 259-266. PubMed Europe PubMed DOI P
Hanifa,S., Scott,H.S., Crewther,P., Guipponi,M. and Tan,J. Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice Neuroreport (2010) 21, 897-901. PubMed Europe PubMed DOI K
Holt,S.K., Kwon,E.M., Lin,D.W., Ostrander,E.A. and Stanford,J.L. Association of hepsin gene variants with prostate cancer risk and prognosis Prostate (2010) 70, 1012-1019. PubMed Europe PubMed DOI M
Nakama,S., Oshiro,N. and Aniya,Y. Activation of rat liver microsomal glutathione transferase by hepsin Biol Pharm Bull (2010) 33, 561-567. PubMed Europe PubMed DOI
Nandana,S., Ellwood-Yen,K., Sawyers,C., Wills,M., Weidow,B., Case,T., Vasioukhin,V. and Matusik,R. Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model Prostate (2010) 70, 591-600. PubMed Europe PubMed DOI
Owen,K.A., Qiu,D., Alves,J., Schumacher,A.M., Kilpatrick,L.M., Li,J., Harris,J.L. and Ellis,V. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA Biochem J (2010) 426, 219-228. PubMed Europe PubMed DOI
Raevskaya,A.A., Kuznetsova,E.M., Savvateeva,M.V. and Severin,S.E. Isolation, purification, and study of properties of recombinant hepsin from Escherichia coli Biochemistry (Mosc) (2010) 75, 866-872. PubMed Europe PubMed DOI E I

2009

Beliveau,F., Desilets,A. and Leduc,R. Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides FEBS J (2009) 276, 2213-2226. PubMed Europe PubMed DOI A P
Halabian,R., Roudkenar,M.H., Esmaeili,N.S., Masroori,N., Roushandeh,A.M. and Najafabadi,A.J. Establishment of a cell line expressing recombinant factor VII and its subsequent conversion to active form FVIIa through hepsin by genetic engineering method Vox Sang (2009) 96, 309-315. PubMed Europe PubMed DOI E
Li,W., Wang,B.E., Moran,P., Lipari,T., Ganesan,R., Corpuz,R., Ludlam,M.J., Gogineni,A., Koeppen,H., Bunting,S., Gao,W.Q. and Kirchhofer,D. Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis Cancer Res (2009) 69, 8395-8402. PubMed Europe PubMed DOI

2008

Miao,J., Mu,D., Ergel,B., Singavarapu,R., Duan,Z., Powers,S., Oliva,E. and Orsulic,S. Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model Int J Cancer (2008) 123, 2041-2047. PubMed Europe PubMed DOI PMC EPMC
Nakamura,K., Takamoto,N., Abarzua,F., Hongo,A., Kodama,J., Nasu,Y., Kumon,H. and Hiramatsu,Y. Hepsin inhibits the cell growth of endometrial cancer Int J Mol Med (2008) 22, 389-397. PubMed Europe PubMed DOI
Tripathi,M., Nandana,S., Yamashita,H., Ganesan,R., Kirchhofer,D. and Quaranta,V. Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression J Biol Chem (2008) 283, 30576-30584. PubMed Europe PubMed DOI PMC EPMC P

2007

Betsunoh,H., Mukai,S., Akiyama,Y., Fukushima,T., Minamiguchi,N., Hasui,Y., Osada,Y. and Kataoka,H. Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma Cancer Sci (2007) 98, 491-498. PubMed Europe PubMed DOI
Guipponi,M., Tan,J., Cannon,P.Z., Donley,L., Crewther,P., Clarke,M., Wu,Q., Shepherd,R.K. and Scott,H.S. Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss Am J Pathol (2007) 171, 608-616. PubMed Europe PubMed DOI PMC EPMC K
Qiu,D., Owen,K., Gray,K., Bass,R. and Ellis,V. Roles and regulation of membrane-associated serine proteases Biochem Soc Trans (2007) 35, 583-587. PubMed Europe PubMed DOI
Wu,Q. and Parry,G. Hepsin and prostate cancer Front Biosci (2007) 12, 5052-5059. PubMed Europe PubMed DOI

2006

Kunii,D., Shimoji,M., Nakama,S., Ikebe,M., Hachiman,T., Sato,I., Tamaki,A., Yamazaki,K. and Aniya,Y. Purification of liver serine protease which activates microsomal glutathione s-transferase: possible involvement of hepsin Biol Pharm Bull (2006) 29, 868-874. PubMed Europe PubMed DOI
Moran,P., Li,W., Fan,B., Vij,R., Eigenbrot,C. and Kirchhofer,D. Pro-urokinase-type plasminogen activator is a substrate for hepsin J Biol Chem (2006) 281, 30439-30446. PubMed Europe PubMed DOI P
Nakamura,K., Nasu,Y., Hongo,A., Matsuo,T., Kodama,J., Ebara,S., Nagai,A., Abrzua,F., Kumon,H. and Hiramatsu,Y. Hepsin shows inhibitory effects through apoptotic pathway on ovarian cancer cell lines Int J Oncol (2006) 28, 393-398. PubMed Europe PubMed
[YEAR:17-6-2006]Pal,P., Xi,H., Kaushal,R., Sun,G., Jin,C.H., Jin,L., Suarez,B.K., Catalona,W.J. and Deka,R. Variants in the HEPSIN gene are associated with prostate cancer in men of European origin Hum Genet (17-6-2006) 120, 187-192. PubMed Europe PubMed DOI
[YEAR:1-4-2006]Xuan,J.A., Schneider,D., Toy,P., Lin,R., Newton,A., Zhu,Y., Finster,S., Vogel,D., Mintzer,B., Dinter,H., Light,D., Parry,R., Polokoff,M., Whitlow,M., Wu,Q. and Parry,G. Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture Cancer Res (1-4-2006) 66, 3611-3619. PubMed Europe PubMed DOI

2005

[YEAR:20-4-2005]Herter,S., Piper,D.E., Aaron,W., Gabriele,T., Cutler,G., Cao,P., Bhatt,A.S., Choe,Y., Craik,C.S., Walker,N., Meininger,D., Hoey,T. and Austin,R.J. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers Biochem J (20-4-2005) 390, 125-136. PubMed Europe PubMed DOI PMC EPMC P
[YEAR:28-3-2005]Kirchhofer,D., Peek,M., Lipari,M.T., Billeci,K., Fan,B. and Moran,P. Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2 FEBS Lett (28-3-2005) 579, 1945-1950. PubMed Europe PubMed DOI
[YEAR:11-1-2005]Li,Y., Yu,Z., Zhao,X. and Shen,S.H. Identification and characterization of hepsin/-TM, a non-transmembrane hepsin isoform Biochim Biophys Acta (11-1-2005) 1681, 157-165. PubMed Europe PubMed DOI R
[YEAR:21-12-2005]Zhang,J.L., Zhao,W.G., Wu,K.L., Wang,K., Zhang,X., Gu,C.F., Li,Y., Zhu,Y. and Wu,J.G. Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease hepsin Arch Virol (21-12-2005) 150, 721-741. PubMed Europe PubMed DOI

2004

Klezovitch,O., Chevillet,J., Mirosevich,J., Roberts,R.L., Matusik,R.J. and Vasioukhin,V. Hepsin promotes prostate cancer progression and metastasis Cancer Cell (2004) 6, 185-195. PubMed Europe PubMed DOI
Kurachi,K. and Yamamoto,K. Hepsin [ISSN:0-12-079610-4] (2004) 2, 1699-1702. V
Stephan,C., Yousef,G.M., Scorilas,A., Jung,K., Jung,M., Kristiansen,G., Hauptmann,S., Kishi,T., Nakamura,T., Loening,S.A. and Diamandis,E.P. Hepsin is highly over expressed in and a new candidate for a prognostic indicator in prostate cancer J Urol (2004) 171, 187-191. PubMed Europe PubMed DOI
[YEAR:28-11-2004]Vasioukhin,V. Hepsin paradox reveals unexpected complexity of metastatic process Cell Cycle (28-11-2004) 3, 1394-1397. PubMed Europe PubMed

2003

Somoza,J.R., Ho,J.D., Luong,C., Ghate,M., Sprengeler,P.A., Mortara,K., Shrader,W.D., Sperandio,D., Chan,H., McGrath,M.E. and Katz,B.A. The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain Structure (2003) 11, 1123-1131. PubMed Europe PubMed DOI S
Szabo,R., Wu,Q., Dickson,R.B., Netzel-Arnett,S., Antalis,T.M. and Bugge,T.H. Type II transmembrane serine proteases Thromb Haemost (2003) 90, 185-193. PubMed Europe PubMed DOI V

2002

[YEAR:1-12-2002]Srikantan,V., Valladares,M., Rhim,J.S., Moul,J.W. and Srivastava,S. HEPSIN inhibits cell growth/invasion in prostate cancer cells Cancer Res (1-12-2002) 62, 6812-6816. PubMed Europe PubMed

2001

[YEAR:1-8-2001]Magee,J.A., Araki,T., Patil,S., Ehrig,T., True,L., Humphrey,P.A., Catalona,W.J., Watson,M.A. and Milbrandt,J. Expression profiling reveals hepsin overexpression in prostate cancer Cancer Res (1-8-2001) 61, 5692-5696. PubMed Europe PubMed
Wu,Q. Gene targeting in hemostasis. Hepsin Front Biosci (2001) 6, D192-D200. PubMed Europe PubMed

2000

Yu,I.S., Chen,H.J., Lee,Y.S., Huang,P.H., Lin,S.R., Tsai,T.W. and Lin,S.W. Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability Thromb Haemost (2000) 84, 865-870. PubMed Europe PubMed K

1999

Kawamura,S., Kurachi,S., Deyashiki,Y. and Kurachi,K. Complete nucleotide sequence, origin of isoform and functional characterization of the mouse hepsin gene Eur J Biochem (1999) 262, 755-764. PubMed Europe PubMed DOI

1998

[YEAR:15-1-1998]Wu,Q., Yu,D., Post,J., Halks-Miller,M., Sadler,J.E. and Morser,J. Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease J Clin Invest (15-1-1998) 101, 321-326. PubMed Europe PubMed DOI PMC EPMC K
Zacharski,L.R., Ornstein,D.L., Memoli,V.A., Rousseau,S.M. and Kisiel,W. Expression of the factor VII activating protease, hepsin, in situ in renal cell carcinoma Thromb Haemost (1998) 79, 876-877. PubMed Europe PubMed

1997

Matsuzaki,H., Jeohn,G.H., Iwamatsu,A., Tamanoue,Y., Kim,Y.T., Takahashi,T. and Takahashi,K. Evidence for the identity of rat liver microsomal membrane-bound serine proteinase with hepsin Protein Pept Lett (1997) 4, 55-62.
Tanimoto,H., Yan,Y., Clarke,J., Korourian,S., Shigemasa,K., Parmley,T.H., Parham,G.P. and O'Brien,T.J. Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer Cancer Res (1997) 57, 2884-2887. PubMed Europe PubMed
[YEAR:12-12-1997]Vu,T.K., Liu,R.W., Haaksma,C.J., Tomasek,J.J. and Howard,E.W. Identification and cloning of the membrane-associated serine protease, hepsin, from mouse preimplantation embryos J Biol Chem (12-12-1997) 272, 31315-31320. PubMed Europe PubMed DOI
Zhukov,A., Hellman,U. and Ingelman-Sundberg,M. Purification and characterization of hepsin from rat liver microsomes Biochim Biophys Acta (1997) 1337, 85-95. PubMed Europe PubMed DOI

1995

Kazama,Y., Hamamoto,T., Foster,D.C. and Kisiel,W. Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation J Biol Chem (1995) 270, 66-72. PubMed Europe PubMed DOI

1994

Kurachi,K., Torres-Rosado,A. and Tsuji,A. Hepsin Methods Enzymol (1994) 244, 100-114. PubMed Europe PubMed DOI V

1993

[YEAR:25-6-1993]Farley,D., Reymond,F. and Nick,H. Cloning and sequence analysis of rat hepsin, a cell surface serine proteinase Biochim Biophys Acta (25-6-1993) 1173, 350-352. PubMed Europe PubMed DOI
Torres-Rosado,A., O'Shea,K.S., Tsuji,A., Chou,S.H. and Kurachi,K. Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth Proc Natl Acad Sci U S A (1993) 90, 7181-7185. PubMed Europe PubMed PMC EPMC
[YEAR:30-11-1993]Zhukov,A., Werlinder,V. and Ingelman-Sundberg,M. Purification and characterization of two membrane bound serine proteinases from rat liver microsomes active in degradation of cytochrome P450 Biochem Biophys Res Commun (30-11-1993) 197, 221-228. PubMed Europe PubMed DOI

1991

Tsuji,A., Torres-Rosado,A., Arai,T., Le Beau,M.M., Lemons,R.S., Chou,S.H. and Kurachi,K. Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization J Biol Chem (1991) 266, 16948-16953. PubMed Europe PubMed
Tsuji,A., Torres-Rosado,A., Arai,T., Chou,S.H. and Kurachi,K. Characterization of hepsin, a membrane bound protease Biomed Biochim Acta (1991) 50, 791-793. PubMed Europe PubMed

1988

Leytus,S.P., Loeb,K.R., Hagen,F.S., Kurachi,K. and Davie,E.W. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells Biochemistry (1988) 27, 1067-1074. PubMed Europe PubMed

1984

Nakamura,T., Asami,O., Tanaka,K. and Ichihara,A. Increased survival of rat hepatocytes in serum-free medium by inhibition of a trypsin-like protease associated with their plasma membranes Exp Cell Res (1984) 155, 81-91. PubMed Europe PubMed
Tanaka,K., Nakamura,T. and Ichihara,A. A novel trypsin-like endoprotease associated with plasma membranes of rat liver and related with the survival of hepatocytes in primary culture (1984) 3, 261-263.