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Literature for peptidase S01.224: hepsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Jin,Z., Zhang,Y., Chen,W., Li,H., Shi,L., Wang,D., Zhu,R. and Zhang,C.
    Intracellular autoactivation and surface location of hepsin, TMPRSS2, and TMPRSS13
    Life Sci (2024) , 123299-123299. PubMed  Europe PubMed DOI
  2. Yang,T.H., Hsu,Y.C., Yeh,P., Hung,C.J., Tsai,Y.F., Fang,M.C., Yen,A.C.C., Chen,L.F., Pan,J.Y., Wu,C.C., Liu,T.C., Chung,F.L., Yu,W.M. and Lin,S.W.
    Critical role of hepsin/TMPRSS1 in hearing and tectorial membrane morphogenesis: Insights from transgenic mouse models
    Hear Res (2024) 453, 109134-109134. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Bergeron,J.J.M. and Thomas,D.Y.
    N-glycosylation mediated folding and quality control in serine proteases of the hepsin family
    FEBS J (2023) 290, 3963-3965. PubMed  Europe PubMed DOI
  4. Rodenas,M.C., Penas-Martinez,J., Pardo-Sanchez,I., Zaragoza-Huesca,D., Ortega-Sabater,C., Pena-Garcia,J., Espin,S., Ricote,G., Montenegro,S., Ayala-De La Pena,F., Luengo-Gil,G., Nieto,A., Garcia-Molina,F., Vicente,V., Bernardi,F., Lozano,M.L., Mulero,V., Perez-Sanchez,H., Carmona-Bayonas,A. and Martinez-Martinez,I.
    Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells
    Front Mol Biosci (2023) 10, 1182925-1182925. PubMed  Europe PubMed DOI  PMC  EPMC  I
  5. Wu,Q., Li,S., Zhang,X. and Dong,N.
    Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function
    Biomedicines (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
    6. 2022
  6. Knaff,P.M., Muller,P., Kersten,C., Wettstein,L., Munch,J., Landfester,K. and Mailander,V.
    Structure-Based Design of High-Affinity and Selective Peptidomimetic Hepsin Inhibitors
    Biomacromolecules (2022) 23, 2236-2242. PubMed  Europe PubMed DOI
  7. Lu,L., Cole,A., Huang,D., Wang,Q., Guo,Z., Yang,W. and Lu,J.
    Clinical Significance of Hepsin and Underlying Signaling Pathways in Prostate Cancer
    Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
    8. 2020
  8. Blay,V., Li,M.C., Ho,S.P., Stoller,M.L., Hsieh,H.P. and Houston,D.R.
    Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
    Acta Pharm Sin B (2020) 10, 1309-1320. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Knaff,P.M., Kersten,C., Willbold,R., Champanhac,C., Crespy,D., Wittig,R., Landfester,K. and Mailander,V.
    From in silico to experimental validation: tailoring peptide substrates for a serine protease
    Biomacromolecules (2020) 21, 1636-1643. PubMed  Europe PubMed DOI  A  P
  10. Kwon,H., Ha,H., Jeon,H., Jang,J., Son,S.H., Lee,K., Park,S.K. and Byun,Y.
    Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres
    Bioorg Chem (2020) , 104521-104521. PubMed  Europe PubMed DOI
  11. Li,S., Peng,J., Wang,H., Zhang,W., Brown,J.M., Zhou,Y. and Wu,Q.
    Hepsin enhances liver metabolism and inhibits adipocyte browning in mice
    Proc Natl Acad Sci U S A (2020) 117, 12359-12367. PubMed  Europe PubMed DOI  K
  12. Li,S., Wang,L., Sun,S. and Wu,Q.
    Hepsin: a multifunctional transmembrane serine protease in pathobiology
    FEBS J (2020) PubMed  Europe PubMed DOI  V
  13. Murza,A., Dion,S.P., Boudreault,P.L., Desilets,A., Leduc,R. and Marsault,E.
    Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract - A review of patent literature
    Expert Opin Ther Pat (2020) , 1-18. PubMed  Europe PubMed DOI
  14. Sun,S., Wang,L., Zhang,S., Zhang,C., Chen,Y., Wu,Q. and Dong,N.
    N-glycan in the scavenger receptor cysteine-rich domain of hepsin promotes intracellular trafficking and cell surface expression
    Int J Biol Macromol (2020) 161, 818-827. PubMed  Europe PubMed DOI
    15. 2019
  15. Damalanka,V.C., Han,Z., Karmakar,P., O'Donoghue,A.J., La Greca,F., Kim,T., Pant,S.M., Helander,J., Klefstrom,J., Craik,C.S. and Janetka,J.W.
    Discovery of selective matriptase and hepsin serine protease inhibitors: useful chemical tools for cancer cell biology
    J Med Chem (2019) 62, 480-490. PubMed  Europe PubMed DOI  I
  16. Damalanka,V.C. and Janetka,J.W.
    Recent progress on inhibitors of the type II transmembrane serine proteases, hepsin, matriptase and matriptase-2
    Future Med Chem (2019) 11, 743-769. PubMed  Europe PubMed DOI  I
  17. Damalanka,V.C., Wildman,S.A. and Janetka,J.W.
    Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin
    MedChemComm (2019) 10, 1646-1655. PubMed  Europe PubMed DOI  PMC  EPMC  I
  18. Kim,K., Kwon,H., Choi,D., Lim,T., Minn,I., Son,S.H. and Byun,Y.
    Design and synthesis of dye-conjugated hepsin inhibitors
    Bioorg Chem (2019) 89, 102990-102990. PubMed  Europe PubMed DOI  L  I
  19. Olinger,E., Lake,J., Sheehan,S., Schiano,G., Takata,T., Tokonami,N., Debaix,H., Consolato,F., Rampoldi,L., Korstanje,R. and Devuyst,O.
    Hepsin-mediated processing of uromodulin is crucial for salt-sensitivity and thick ascending limb homeostasis
    Sci Rep (2019) 9, 12287-12287. PubMed  Europe PubMed DOI
  20. Wang,L., Zhang,C., Sun,S., Chen,Y., Hu,Y., Wang,H., Liu,M., Dong,N. and Wu,Q.
    Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells
    Biochem J (2019) 476, 2355-2369. PubMed  Europe PubMed DOI
  21. Willbold,R., Wirth,K., Martini,T., Sultmann,H., Bolenz,C. and Wittig,R.
    Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells
    Cell Death Dis (2019) 10, 601-601. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2018
  22. Pant,S.M., Belitskin,D., Ala-Hongisto,H., Klefstrom,J. and Tervonen,T.A.
    Analyzing the type II transmembrane serine protease hepsin-dependent basement membrane remodeling in 3D cell culture
    Methods Mol Biol (2018) 1731, 169-178. PubMed  Europe PubMed DOI
  23. Pant,S.M., Mukonoweshuro,A., Desai,B., Ramjee,M.K., Selway,C.N., Tarver,G.J., Wright,A.G., Birchall,K., Chapman,T.M., Tervonen,T.A. and Klefstrom,J.
    Design, synthesis, and testing of potent, selective hepsin inhibitors via application of an automated closed-loop optimization platform
    J Med Chem (2018) 61, 4335-4347. PubMed  Europe PubMed DOI  I
    24. 2017
  24. Kwon,H., Han,J., Lee,K.Y., Son,S.H. and Byun,Y.
    Recent advances of hepsin-targeted inhibitors
    Curr Med Chem (2017) 24, 2294-2311. PubMed  Europe PubMed DOI  I
  25. Nassan,M., Jia,Y.F., Jenkins,G., Colby,C., Feeder,S., Choi,D.S., Veldic,M., McElroy,S.L., Bond,D.J., Weinshilboum,R., Biernacka,J.M. and Frye,M.A.
    Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: applications of a proteomic informed genomic approach
    J Psychiatr Res (2017) 95, 208-212. PubMed  Europe PubMed DOI  M
  26. Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D.
    Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases
    Am J Cancer Res (2017) 7, 2257-2274. PubMed  Europe PubMed  PMC  EPMC
  27. Tanabe,L.M. and List,K.
    The role of type II transmembrane serine protease-mediated signaling in cancer
    FEBS J (2017) 284, 1421-1436. PubMed  Europe PubMed DOI  I
  28. Wilkinson,D.J., Desilets,A., Lin,H., Charlton,S., Del Carmen Arques,M., Falconer,A., Bullock,C., Hsu,Y.C., Birchall,K., Hawkins,A., Thompson,P., Ferrell,W.R., Lockhart,J., Plevin,R., Zhang,Y., Blain,E., Lin,S.W., Leduc,R., Milner,J.M. and Rowan,A.D.
    The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover
    Sci Rep (2017) 7, 16693-16693. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Yogo,T., Umezawa,K., Kamiya,M., Hino,R. and Urano,Y.
    Development of an activatable fluorescent probe for prostate cancer imaging
    Bioconjug Chem (2017) 28, 2069-2076. PubMed  Europe PubMed DOI  L
    30. 2016
  30. Han,Z., Harris,P.K., Karmakar,P., Kim,T., Owusu,B.Y., Wildman,S.A., Klampfer,L. and Janetka,J.W.
    alpha-Ketobenzothiazole serine protease inhibitors of aberrant HGF/c-MET and MSP/RON kinase pathway signaling in cancer
    ChemMedChem (2016) 11, 585-599. PubMed  Europe PubMed DOI  I
  31. Kwon,H., Kim,Y., Park,K., Choi,S.A., Son,S.H. and Byun,Y.
    Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors
    Bioorg Med Chem Lett (2016) 26, 310-314. PubMed  Europe PubMed DOI  I
  32. Tervonen,T.A., Belitskin,D., Pant,S.M., Englund,J.I., Marques,E., Ala-Hongisto,H., Nevalaita,L., Sihto,H., Heikkila,P., Leidenius,M., Hewitson,K., Ramachandra,M., Moilanen,A., Joensuu,H., Kovanen,P.E., Poso,A. and Klefstrom,J.
    Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion
    Oncogene (2016) 35, 1832-1846. PubMed  Europe PubMed DOI
  33. Venukadasula,P.K., Owusu,B.Y., Bansal,N., Ross,L.J., Hobrath,J.V., Bao,D., Truss,J.W., Stackhouse,M., Messick,T.E., Klampfer,L. and Galemmo RA Jr
    Design and synthesis of nonpeptide inhibitors of hepatocyte growth factor activation
    ACS Med Chem Lett (2016) 7, 177-181. PubMed  Europe PubMed DOI  PMC  EPMC  I
  34. Zhang,M., Gu,J. and Zhang,C.
    Hepatitis B virus X protein binding to hepsin promotes C3 production by inducing IL-6 secretion from hepatocytes
    Oncotarget (2016) 7, 7780-7800. PubMed  Europe PubMed DOI
    35. 2015
  35. Brunati,M., Perucca,S., Han,L., Cattaneo,A., Consolato,F., Andolfo,A., Schaeffer,C., Olinger,E., Peng,J., Santambrogio,S., Perrier,R., Li,S., Bokhove,M., Bachi,A., Hummler,E., Devuyst,O., Wu,Q., Jovine,L. and Rampoldi,L.
    The serine protease hepsin mediates urinary secretion and polymerisation of zona pellucida domain protein uromodulin
    elife (2015) 4, e08887- PubMed  Europe PubMed DOI
  36. Franco,F.M., Jones,D.E., Harris,P.K., Han,Z., Wildman,S.A., Jarvis,C.M. and Janetka,J.W.
    Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: evaluation of potency and selectivity derived from distinct binding pockets
    Bioorg Med Chem (2015) 23, 2328-2343. PubMed  Europe PubMed DOI  I
  37. Goswami,R., Wohlfahrt,G., Tormakangas,O., Moilanen,A., Lakshminarasimhan,A., Nagaraj,J., Arumugam,K.N., Mukherjee,S., Chacko,A.R., Krishnamurthy,N.R., Jaleel,M., Palakurthy,R.K., Samiulla,D.S. and Ramachandra,M.
    Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors
    Bioorg Med Chem Lett (2015) 25, 5309-5314. PubMed  Europe PubMed DOI  I
  38. Niehaus,J.Z., Miedel,M.T., Good,M., Wyatt,A.N., Pak,S.C., Silverman,G.A. and Luke,C.J.
    SERPINB12 is a slow-binding inhibitor of granzyme A and hepsin
    Biochemistry (2015) 54, 6756-6759. PubMed  Europe PubMed DOI
  39. Zhang,C., Zhang,M., Wu,Q., Peng,J., Ruan,Y. and Gu,J.
    Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2alpha phosphorylation in prostate cancer
    Cell Signal (2015) 27, 789-797. PubMed  Europe PubMed DOI
    40. 2014
  40. Barre,O., Dufour,A., Eckhard,U., Kappelhoff,R., Beliveau,F., Leduc,R. and Overall,C.M.
    Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries
    PLoS ONE (2014) 9, e105984-e105984. PubMed  Europe PubMed DOI  PMC  EPMC  P
  41. Han,Z., Harris,P.K., Jones,D.E., Chugani,R., Kim,T., Agarwal,M., Shen,W., Wildman,S.A. and Janetka,J.W.
    Inhibitors of HGFA, matriptase, and hepsin serine proteases: a nonkinase strategy to block cell signaling in cancer
    ACS Med Chem Lett (2014) 5, 1219-1224. PubMed  Europe PubMed DOI  PMC  EPMC  I
  42. Khandekar,G. and Jagadeeswaran,P.
    Role of hepsin in factor VII activation in zebrafish
    Blood Cells Mol Dis (2014) 52, 76-81. PubMed  Europe PubMed DOI
  43. Tang,X., Mahajan,S.S., Nguyen,L.T., Beliveau,F., Leduc,R., Simon,J.A. and Vasioukhin,V.
    Targeted inhibition of cell-surface serine protease hepsin blocks prostate cancer bone metastasis
    Oncotarget (2014) 5, 1352-1362. PubMed  Europe PubMed  I
  44. Wang,C., Guo,L., Yu,D., Hua,X., Yang,Z., Yuan,C. and Cui,L.
    HEV-ORF3 encoding phosphoprotein interacts with hepsin
    Hepat Mon (2014) 14, e13902-e13902. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2013
  45. Guo,J., Li,G., Tang,J., Cao,X.B., Zhou,Q.Y., Fan,Z.J., Zhu,B. and Pan,X.H.
    HLA-A2-restricted cytotoxic T lymphocyte epitopes from human hepsin as novel targets for prostate cancer immunotherapy
    Scand J Immunol (2013) 78, 248-257. PubMed  Europe PubMed DOI  T
    46. 2012
  46. Hsu,Y.C., Huang,H.P., Yu,I.S., Su,K.Y., Lin,S.R., Lin,W.C., Wu,H.L., Shi,G.Y., Tao,M.H., Kao,C.H., Wu,Y.M., Martin,P.E., Lin,S.Y., Yang,P.C. and Lin,S.W.
    Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice
    Hepatology (2012) 56, 1913-1923. PubMed  Europe PubMed DOI
  47. Koschubs,T., Dengl,S., Durr,H., Kaluza,K., Georges,G., Hartl,C., Jennewein,S., Lanzendorfer,M., Auer,J., Stern,A., Huang,K.S., Packman,K., Gubler,U., Kostrewa,D., Ries,S., Hansen,S., Kohnert,U., Cramer,P. and Mundigl,O.
    Allosteric antibody inhibition of human hepsin protease
    Biochem J (2012) 442, 483-494. PubMed  Europe PubMed DOI
  48. Wu,Q. and Peng,J.
    Hepsin
    [ISSN:978-0-12-407742-3] (2012) 3, 2985-2989. DOI
    49. 2011
  49. Antalis,T.M., Bugge,T.H. and Wu,Q.
    Membrane-anchored serine proteases in health and disease
    Prog Mol Biol Transl Sci (2011) 99, 1-50. PubMed  Europe PubMed DOI  V
  50. Ganesan,R., Kolumam,G.A., Lin,S.J., Xie,M.H., Santell,L., Wu,T.D., Lazarus,R.A., Chaudhuri,A. and Kirchhofer,D.
    Proteolytic activation of pro-macrophage-stimulating protein by hepsin
    Mol Cancer Res (2011) 9, 1175-1186. PubMed  Europe PubMed DOI
  51. Wittig-Blaich,S.M., Kacprzyk,L.A., Eismann,T., Bewerunge-Hudler,M., Kruse,P., Winkler,E., Strauss,W.S., Hibst,R., Steiner,R., Schrader,M., Mertens,D., Sultmann,H. and Wittig,R.
    Matrix-dependent regulation of AKT in hepsin-overexpressing PC3 prostate cancer cells
    Neoplasia (2011) 13, 579-589. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Xing,P., Li,J.G., Jin,F., Zhao,T.T., Liu,Q., Dong,H.T. and Wei,X.L.
    Clinical and biological significance of hepsin overexpression in breast cancer
    J Investig Med (2011) 59, 803-810. PubMed  Europe PubMed DOI  T
    53. 2010
  53. Camerer,E., Barker,A., Duong,D.N., Ganesan,R., Kataoka,H., Cornelissen,I., Darragh,M.R., Hussain,A., Zheng,Y.W., Srinivasan,Y., Brown,C., Xu,S.M., Regard,J.B., Lin,C.Y., Craik,C.S., Kirchhofer,D. and Coughlin,S.R.
    Local protease signaling contributes to neural tube closure in the mouse embryo
    Dev Cell (2010) 18, 25-38. PubMed  Europe PubMed DOI  PMC  EPMC
  54. Chen,M., Chen,L.M., Lin,C.Y. and Chai,K.X.
    Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor
    Mol Cell Biochem (2010) 337, 259-266. PubMed  Europe PubMed DOI  P
  55. Hanifa,S., Scott,H.S., Crewther,P., Guipponi,M. and Tan,J.
    Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice
    Neuroreport (2010) 21, 897-901. PubMed  Europe PubMed DOI  K
  56. Holt,S.K., Kwon,E.M., Lin,D.W., Ostrander,E.A. and Stanford,J.L.
    Association of hepsin gene variants with prostate cancer risk and prognosis
    Prostate (2010) 70, 1012-1019. PubMed  Europe PubMed DOI  M
  57. Nakama,S., Oshiro,N. and Aniya,Y.
    Activation of rat liver microsomal glutathione transferase by hepsin
    Biol Pharm Bull (2010) 33, 561-567. PubMed  Europe PubMed DOI
  58. Nandana,S., Ellwood-Yen,K., Sawyers,C., Wills,M., Weidow,B., Case,T., Vasioukhin,V. and Matusik,R.
    Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model
    Prostate (2010) 70, 591-600. PubMed  Europe PubMed DOI
  59. Owen,K.A., Qiu,D., Alves,J., Schumacher,A.M., Kilpatrick,L.M., Li,J., Harris,J.L. and Ellis,V.
    Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
    Biochem J (2010) 426, 219-228. PubMed  Europe PubMed DOI
  60. Raevskaya,A.A., Kuznetsova,E.M., Savvateeva,M.V. and Severin,S.E.
    Isolation, purification, and study of properties of recombinant hepsin from Escherichia coli
    Biochemistry (Mosc) (2010) 75, 866-872. PubMed  Europe PubMed DOI  E  I
    61. 2009
  61. Beliveau,F., Desilets,A. and Leduc,R.
    Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides
    FEBS J (2009) 276, 2213-2226. PubMed  Europe PubMed DOI  A  P
  62. Halabian,R., Roudkenar,M.H., Esmaeili,N.S., Masroori,N., Roushandeh,A.M. and Najafabadi,A.J.
    Establishment of a cell line expressing recombinant factor VII and its subsequent conversion to active form FVIIa through hepsin by genetic engineering method
    Vox Sang (2009) 96, 309-315. PubMed  Europe PubMed DOI  E
  63. Li,W., Wang,B.E., Moran,P., Lipari,T., Ganesan,R., Corpuz,R., Ludlam,M.J., Gogineni,A., Koeppen,H., Bunting,S., Gao,W.Q. and Kirchhofer,D.
    Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis
    Cancer Res (2009) 69, 8395-8402. PubMed  Europe PubMed DOI
    64. 2008
  64. Miao,J., Mu,D., Ergel,B., Singavarapu,R., Duan,Z., Powers,S., Oliva,E. and Orsulic,S.
    Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model
    Int J Cancer (2008) 123, 2041-2047. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Nakamura,K., Takamoto,N., Abarzua,F., Hongo,A., Kodama,J., Nasu,Y., Kumon,H. and Hiramatsu,Y.
    Hepsin inhibits the cell growth of endometrial cancer
    Int J Mol Med (2008) 22, 389-397. PubMed  Europe PubMed DOI
  66. Tripathi,M., Nandana,S., Yamashita,H., Ganesan,R., Kirchhofer,D. and Quaranta,V.
    Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression
    J Biol Chem (2008) 283, 30576-30584. PubMed  Europe PubMed DOI  PMC  EPMC  P
    67. 2007
  67. Betsunoh,H., Mukai,S., Akiyama,Y., Fukushima,T., Minamiguchi,N., Hasui,Y., Osada,Y. and Kataoka,H.
    Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma
    Cancer Sci (2007) 98, 491-498. PubMed  Europe PubMed DOI
  68. Guipponi,M., Tan,J., Cannon,P.Z., Donley,L., Crewther,P., Clarke,M., Wu,Q., Shepherd,R.K. and Scott,H.S.
    Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss
    Am J Pathol (2007) 171, 608-616. PubMed  Europe PubMed DOI  PMC  EPMC  K
  69. Qiu,D., Owen,K., Gray,K., Bass,R. and Ellis,V.
    Roles and regulation of membrane-associated serine proteases
    Biochem Soc Trans (2007) 35, 583-587. PubMed  Europe PubMed DOI
  70. Wu,Q. and Parry,G.
    Hepsin and prostate cancer
    Front Biosci (2007) 12, 5052-5059. PubMed  Europe PubMed DOI
    71. 2006
  71. Kunii,D., Shimoji,M., Nakama,S., Ikebe,M., Hachiman,T., Sato,I., Tamaki,A., Yamazaki,K. and Aniya,Y.
    Purification of liver serine protease which activates microsomal glutathione s-transferase: possible involvement of hepsin
    Biol Pharm Bull (2006) 29, 868-874. PubMed  Europe PubMed DOI
  72. Moran,P., Li,W., Fan,B., Vij,R., Eigenbrot,C. and Kirchhofer,D.
    Pro-urokinase-type plasminogen activator is a substrate for hepsin
    J Biol Chem (2006) 281, 30439-30446. PubMed  Europe PubMed DOI  P
  73. Nakamura,K., Nasu,Y., Hongo,A., Matsuo,T., Kodama,J., Ebara,S., Nagai,A., Abrzua,F., Kumon,H. and Hiramatsu,Y.
    Hepsin shows inhibitory effects through apoptotic pathway on ovarian cancer cell lines
    Int J Oncol (2006) 28, 393-398. PubMed  Europe PubMed
  74. [YEAR:17-6-2006]Pal,P., Xi,H., Kaushal,R., Sun,G., Jin,C.H., Jin,L., Suarez,B.K., Catalona,W.J. and Deka,R.
    Variants in the HEPSIN gene are associated with prostate cancer in men of European origin
    Hum Genet (17-6-2006) 120, 187-192. PubMed  Europe PubMed DOI
  75. [YEAR:1-4-2006]Xuan,J.A., Schneider,D., Toy,P., Lin,R., Newton,A., Zhu,Y., Finster,S., Vogel,D., Mintzer,B., Dinter,H., Light,D., Parry,R., Polokoff,M., Whitlow,M., Wu,Q. and Parry,G.
    Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture
    Cancer Res (1-4-2006) 66, 3611-3619. PubMed  Europe PubMed DOI
    76. 2005
  76. [YEAR:20-4-2005]Herter,S., Piper,D.E., Aaron,W., Gabriele,T., Cutler,G., Cao,P., Bhatt,A.S., Choe,Y., Craik,C.S., Walker,N., Meininger,D., Hoey,T. and Austin,R.J.
    Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
    Biochem J (20-4-2005) 390, 125-136. PubMed  Europe PubMed DOI  PMC  EPMC  P
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