$VAR1 = undef;

Summary for peptidase S01.223: acrosin

Names
MEROPS Name	acrosin
Other names	acrosomal proteinase

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.223
Holotype	acrosin (Sus scrofa), Uniprot accession P08001 (peptidase unit: 40-290), MERNUM MER0000079
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00316
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.10
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Adham et al., 2004) mouse: active (Brown, 1983)
Physiology	Presumed role in fertilization.
Knockout	Mice lacking acrosin are fertile, but the Acr(-) sperm have a selective disadvantage when they are in competition with Acr(+) sperm (Adham et al., 1997).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Acrosin