Substrates for peptidase S01.223: acrosin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
acrosin precursor	P08001	17-415	peptide-Arg23+Val-peptide	P	Ser	Gly	Met	Arg	Val	Val	Gly	Gly		17419
arginyl bond			peptide-Arg+peptide	N	-	-	NPe	Arg	CPe	-	-	-	Adham et al., 2004
Bz-Arg-NHPhNO2 (BAPNA)			Bz-Arg+NHPhNO2	S	-	-	Bz	Arg	NAN	-	-	-	Adham et al., 2004
Bz-Arg-OEt [BAEE]			Bz-Arg+OEt	S	-	-	Bz	Arg	OEt	-	-	-
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg+Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Cya	Gly	Glu	Arg	Gly	Phe	Phe	Tyr	McRorie et al., 1976
lysyl bond			peptide-Lys+peptide	N	-	-	NPe	Lys	CPe	-	-	-	Adham et al., 2004