$VAR1 = undef;

Summary for peptidase S01.159: prostasin

Names
MEROPS Name	prostasin
Other names	CAP1, channel-activating protease-1, PRSS8 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.159
Holotype	prostasin (Homo sapiens), Uniprot accession Q16651 (peptidase unit: 45-288), MERNUM MER0002460
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00288
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Chao, 2004) mouse: active (Vuagniaux et al., 2000)
Physiology	An endopeptidase known from epithelial cells of Xenopus and mouse that can activate the amiloride-sensitive sodium channel (ENaC) in mammalian kidney epithelial cells, and may act as a regulator of ENaC within the kidney (Vuagniaux et al., 2000).
Knockout	Prostasin expression in the epidermis is crucial for the epidermal permeability barrier and indispensable for postnatal survival (Leyvraz, et al. 2005).
Other databases	TREEFAM	http://www.treefam.org/family/TF351676