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Literature for peptidase S01.159: prostasin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,H., Zhang,L., Zhang,L., Liu,T., Pang,X., Fan,C. and Jiang,H.
    m6A Modification Destabilizes Prss8 and Activates Hepatic Stellate Cells via TLR4-Mediated Inflammatory Responses
    DNA Cell Biol (2025) PubMed  Europe PubMed DOI
  2. Mizoo,T., Oka,T., Sugahara,O., Minato,T., Higa,T. and Nakayama,K.I.
    GPLD1+ cancer stem cells contribute to chemotherapy resistance and tumor relapse in intestinal cancer
    J Biochem (2025) PubMed  Europe PubMed DOI
  3. Ren,H., Zhao,T., Lv,Z., Xie,G. and Sun,H.
    Prospective association of the triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio with anxiety risk in a community-based cohort: a UK Biobank study
    BMJ Open (2025) 15, e103997-e103997. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2023
  4. Ehret,E., Stroh,S., Auberson,M., Ino,F., Jager,Y., Maillard,M., Szabo,R., Bugge,T.H., Frateschi,S. and Hummler,E.
    Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
    Cells (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Shamseldin,H.E., Derar,N., Alzaidan,H., AlHathal,N., Alfalah,A., Abdulwahab,F., Alzaid,T., Alkeraye,S., Alobaida,S.A. and Alkuraya,F.S.
    PRSS8, encoding prostasin, is mutated in patients with autosomal recessive ichthyosis
    Hum Genet (2023) 142, 477-482. PubMed  Europe PubMed DOI
    6. 2021
  6. Essigke,D., Ilyaskin,A.V., Worn,M., Bohnert,B.N., Xiao,M., Daniel,C., Amann,K., Birkenfeld,A.L., Szabo,R., Bugge,T.H., Korbmacher,C. and Artunc,F.
    Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice
    Acta Physiol (Oxf) (2021) , e13640-e13640. PubMed  Europe PubMed DOI
  7. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
    Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Frindt,G., Shi,S., Kleyman,T.R. and Palmer,L.G.
    Cleavage state of gammaENaC in mouse and rat kidney
    Am J Physiol Renal Physiol (2021) PubMed  Europe PubMed DOI
    9. 2020
  9. Chang,S.C., Chiang,C.P., Lai,C.H., Du,P.A., Hung,Y.S., Chen,Y.H., Yang,H.Y., Fang,H.Y., Lee,S.P., Tang,H.J., Wang,J.K., Johnson,M.D. and Lin,C.Y.
    Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin
    Hum Cell (2020) PubMed  Europe PubMed DOI
  10. Ejaz,S., Ali,A., Azim,K., Mahmood,A., Khan,A.I., Almazyad,T.A. and Bilal,B.
    Association between preeclampsia and prostasin polymorphism in Pakistani females
    Saudi Med J (2020) 41, 1234-1240. PubMed  Europe PubMed DOI
  11. Holt-Danborg,L., Skovbjerg,S., Goderum,K.W., Nonboe,A.W., Stankevic,E., Frost,A.K., Vitved,L., Jensen,J.K. and Vogel,L.K.
    Insights into the regulation of the matriptase-prostasin proteolytic system
    Biochem J (2020) PubMed  Europe PubMed DOI
  12. Murray,A.S., Hyland,T.E., Sala-Hamrick,K.E., Mackinder,J.R., Martin,C.E., Tanabe,L.M., Varela,F.A. and List,K.
    The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy
    Oncogene (2020) PubMed  Europe PubMed DOI  K
    13. 2019
  13. Bao,Y., Guo,Y., Yang,Y., Wei,X., Zhang,S., Zhang,Y., Li,K., Yuan,M., Guo,D., Macias,V., Zhu,X., Zhang,W. and Yang,W.
    PRSS8 suppresses colorectal carcinogenesis and metastasis
    Oncogene (2019) 38, 497-517. PubMed  Europe PubMed DOI  K
  14. Lin,C.K., Tseng,C.K., Wu,Y.H., Lin,C.Y., Huang,C.H., Wang,W.H., Liaw,C.C., Chen,Y.H. and Lee,J.C.
    Prostasin impairs epithelial growth factor receptor activation to suppress dengue virus propagation
    J Infect Dis (2019) 219, 1377-1388. PubMed  Europe PubMed DOI
    15. 2018
  15. Szabo,R. and Bugge,T.H.
    Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy
    PLoS ONE (2018) 13, e0194660-e0194660. PubMed  Europe PubMed DOI  M
    16. 2017
  16. Shiao,F., Liu,L.O., Huang,N., Lai,Y.J., Barndt,R.J., Tseng,C.C., Wang,J.K., Jia,B., Johnson,M.D. and Lin,C.Y.
    Selective inhibition of prostasin in human enterocytes by the integral membrane Kunitz-type serine protease inhibitor HAI-2
    PLoS ONE (2017) 12, e0170944-e0170944. PubMed  Europe PubMed DOI
    17. 2016
  17. Friis,S., Madsen,D.H. and Bugge,T.H.
    Distinct developmental functions of prostasin (CAP1/PRSS8) zymogen and activated prostasin
    J Biol Chem (2016) 291, 2577-2582. PubMed  Europe PubMed DOI
  18. Hou,J.
    Paracellular transport in the collecting duct
    Curr Opin Nephrol Hypertens (2016) 25, 424-428. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Su,H.C., Liang,Y.A., Lai,Y.J., Chiu,Y.L., Barndt,R.B., Shiao,F., Chang,H.D., Lu,D.D., Huang,N., Tseng,C.C., Wang,J.K., Lee,M.S., Johnson,M.D., Huang,S.M. and Lin,C.Y.
    Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner
    PLoS ONE (2016) 11, e0167894-e0167894. PubMed  Europe PubMed DOI
  20. Szabo,R., Lantsman,T., Peters,D.E. and Bugge,T.H.
    Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin
    Development (2016) 143, 2818-2828. PubMed  Europe PubMed DOI  K
    21. 2015
  21. Uchimura,K. and Kitamura,K.
    [Prostasin (PRSS8) as a new pathological factor]
    Nihon Rinsho (2015) 73, 523-533. PubMed  Europe PubMed
    22. 2014
  22. Carattino,M.D., Mueller,G.M., Palmer,L.G., Frindt,G., Rued,A.C., Hughey,R.P. and Kleyman,T.R.
    Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the gamma-subunit by a second protease
    Am J Physiol Renal Physiol (2014) 307, F1080-F1087. PubMed  Europe PubMed DOI
  23. Crisante,G., Battista,L., Iwaszkiewicz,J., Nesca,V., Merillat,A.-M., Sergi,C., Zoete,V., Frateschi,S. and Hummler,E.
    The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition
    FASEB J (2014) 28, 4792-4805. PubMed  Europe PubMed DOI
  24. Friis,S., Sales,K.U., Schafer,J.M., Vogel,L.K., Kataoka,H. and Bugge,T.H.
    The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin
    J Biol Chem (2014) 289, 22319-22332. PubMed  Europe PubMed DOI
  25. Hamilton,K.L.
    Cleavage: what's up with prostasin AND ENaC these days?
    Am J Physiol Renal Physiol (2014) 307, F1196-F1197. PubMed  Europe PubMed DOI
  26. Peters,D.E., Szabo,R., Friis,S., Shylo,N.A., Uzzun Sales,K., Holmbeck,K. and Bugge,T.H.
    The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity
    J Biol Chem (2014) 289, 14740-14749. PubMed  Europe PubMed DOI
  27. Uchimura,K., Hayata,M., Mizumoto,T., Miyasato,Y., Kakizoe,Y., Morinaga,J., Onoue,T., Yamazoe,R., Ueda,M., Adachi,M., Miyoshi,T., Shiraishi,N., Ogawa,W., Fukuda,K., Kondo,T., Matsumura,T., Araki,E., Tomita,K. and Kitamura,K.
    The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling
    Nat Commun (2014) 5, 3428-3428. PubMed  Europe PubMed DOI  PMC  EPMC  K
    28. 2013
  28. Buzza,M.S., Martin,E.W., Driesbaugh,K.H., Desilets,A., Leduc,R. and Antalis,T.M.
    Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway
    J Biol Chem (2013) 288, 10328-10337. PubMed  Europe PubMed DOI
  29. Friis,S., Uzzun Sales,K., Godiksen,S., Peters,D.E., Lin,C.Y., Vogel,L.K. and Bugge,T.H.
    A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation
    J Biol Chem (2013) 288, 19028-19039. PubMed  Europe PubMed DOI
  30. Hummler,E., Dousse,A., Rieder,A., Stehle,J.C., Rubera,I., Osterheld,M.C., Beermann,F., Frateschi,S. and Charles,R.P.
    The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation
    PLoS ONE (2013) 8, e55796-e55796. PubMed  Europe PubMed DOI  PMC  EPMC  K
  31. Miller,G.S. and List,K.
    The matriptase-prostasin proteolytic cascade in epithelial development and pathology
    Cell Tissue Res (2013) 351, 245-253. PubMed  Europe PubMed DOI
  32. Rowe,S.M., Reeves,G., Hathorne,H., Solomon,G.M., Abbi,S., Renard,D., Lock,R., Zhou,P., Danahay,H., Clancy,J.P. and Waltz,D.A.
    Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis
    Chest (2013) 144, 200-207. PubMed  Europe PubMed DOI  I
    33. 2012
  33. Bergum,C., Zoratti,G., Boerner,J. and List,K.
    Strong expression association between matriptase and its substrate prostasin in breast cancer
    J Cell Physiol (2012) 227, 1604-1609. PubMed  Europe PubMed DOI
  34. Chao,J., Chen,L.M. and Chai,K.X.
    Prostasin
    [ISSN:978-0-12-407742-3] (2012) 3, 3011-3014. DOI
  35. Frateschi,S., Keppner,A., Malsure,S., Iwaszkiewicz,J., Sergi,C., Merillat,A.M., Fowler-Jaeger,N., Randrianarison,N., Planes,C. and Hummler,E.
    Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity
    Am J Pathol (2012) 181, 605-615. PubMed  Europe PubMed DOI  M
  36. Kitamura,K. and Tomita,K.
    Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension
    Clin Exp Nephrol (2012) 16, 44-48. PubMed  Europe PubMed DOI  I
  37. Szabo,R., Uzzun Sales,K., Kosa,P., Shylo,N.A., Godiksen,S., Hansen,K.K., Friis,S., Gutkind,J.S., Vogel,L.K., Hummler,E., Camerer,E. and Bugge,T.H.
    Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation
    PLoS Genet (2012) 8, e1002937-e1002937. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2011
  38. Antalis,T.M., Bugge,T.H. and Wu,Q.
    Membrane-anchored serine proteases in health and disease
    Prog Mol Biol Transl Sci (2011) 99, 1-50. PubMed  Europe PubMed DOI  V
  39. Xu,Z., Chen,Y.W., Battu,A., Wilder,P., Weber,D., Yu,W., Mackerell,A.D., Chen,L.M., Chai,K.X., Johnson,M.D. and Lin,C.Y.
    Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade
    J Med Chem (2011) 54, 7567-7578. PubMed  Europe PubMed DOI  I
    40. 2010
  40. Camerer,E., Barker,A., Duong,D.N., Ganesan,R., Kataoka,H., Cornelissen,I., Darragh,M.R., Hussain,A., Zheng,Y.W., Srinivasan,Y., Brown,C., Xu,S.M., Regard,J.B., Lin,C.Y., Craik,C.S., Kirchhofer,D. and Coughlin,S.R.
    Local protease signaling contributes to neural tube closure in the mouse embryo
    Dev Cell (2010) 18, 25-38. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Chen,Y.W., Wang,J.K., Chou,F.P., Chen,C.Y., Rorke,E.A., Chen,L.M., Chai,K.X., Eckert,R.L., Johnson,M.D. and Lin,C.Y.
    Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation
    J Biol Chem (2010) 285, 31755-31762. PubMed  Europe PubMed DOI
  42. Fu,Y.Y., Gao,W.L., Chen,M., Chai,K.X., Wang,Y.L. and Chen,L.M.
    Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway
    Hum Reprod (2010) 25, 623-632. PubMed  Europe PubMed DOI
  43. Ko,T., Kakizoe,Y., Wakida,N., Hayata,M., Uchimura,K., Shiraishi,N., Miyoshi,T., Adachi,M., Aritomi,S., Konda,T., Tomita,K. and Kitamura,K.
    Regulation of adrenal aldosterone production by serine protease prostasin
    J Biomed Biotechnol (2010) 2010, 793843-793843. PubMed  Europe PubMed DOI  PMC  EPMC  I
  44. Planes,C., Randrianarison,N.H., Charles,R.P., Frateschi,S., Cluzeaud,F., Vuagniaux,G., Soler,P., Clerici,C., Rossier,B.C. and Hummler,E.
    ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1
    EMBO Mol Med (2010) 2, 26-37. PubMed  Europe PubMed DOI  K
  45. Spacek,D.V., Perez,A.F., Ferranti,K.M., Wu,L.K., Moy,D.M., Magnan,D.R. and King,T.R.
    The mouse frizzy (fr) and rat 'hairless' (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8)
    Exp Dermatol (2010) 19, 527-532. PubMed  Europe PubMed DOI  M
    46. 2009
  46. Chen,L.M., Hatfield,M.L., Fu,Y.Y. and Chai,K.X.
    Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells
    Prostate (2009) 69, 1790-1801. PubMed  Europe PubMed DOI
  47. Ma,X.J., Fu,Y.Y., Li,Y.X., Chen,L.M., Chai,K. and Wang,Y.L.
    Prostasin inhibits cell invasion in human choriocarcinomal JEG-3 cells
    Histochem Cell Biol (2009) 132, 639-646. PubMed  Europe PubMed DOI
  48. Spraggon,G., Hornsby,M., Shipway,A., Tully,D.C., Bursulaya,B., Danahay,H., Harris,J.L. and Lesley,S.A.
    Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations
    Protein Sci (2009) 18, 1081-1094. PubMed  Europe PubMed DOI  PMC  EPMC  S
  49. Svenningsen,P., Uhrenholt,T.R., Palarasah,Y., Skjodt,K., Jensen,B.L. and Skott,O.
    Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations
    Am J Physiol Regul Integr Comp Physiol (2009) 297, R1733-R1741. PubMed  Europe PubMed DOI
    50. 2008
  50. Chen,M., Chen,L.M., Lin,C.Y. and Chai,K.X.
    The epidermal growth factor receptor (EGFR) is proteolytically modified by the matriptase-prostasin serine protease cascade in cultured epithelial cells
    Biochim Biophys Acta (2008) 1783, 896-903. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Rickert,K.W., Kelley,P., Byrne,N.J., Diehl,R.E., Hall,D.L., Montalvo,A.M., Reid,J.C., Shipman,J.M., Thomas,B.W., Munshi,S.K., Darke,P.L. and Su,H.P.
    Structure of human prostasin, a target for the regulation of hypertension
    J Biol Chem (2008) 283, 34864-34872. PubMed  Europe PubMed DOI  S
  52. Tully,D.C., Vidal,A., Chatterjee,A.K., Williams,J.A., Roberts,M.J., Petrassi,H.M., Spraggon,G., Bursulaya,B., Pacoma,R., Shipway,A., Schumacher,A.M., Danahay,H. and Harris,J.L.
    Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design
    Bioorg Med Chem Lett (2008) 18, 5895-5899. PubMed  Europe PubMed DOI  S  I
  53. Zhu,H., Guo,D., Li,K., Yan,W., Tan,Y., Wang,X., Treiber,F.A., Chao,J., Snieder,H. and Dong,Y.
    Prostasin: a possible candidate gene for human hypertension
    Am J Hypertens (2008) 21, 1028-1033. PubMed  Europe PubMed DOI
    54. 2007
  54. Bruns,J.B., Carattino,M.D., Sheng,S., Maarouf,A.B., Weisz,O.A., Pilewski,J.M., Hughey,R.P. and Kleyman,T.R.
    Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit
    J Biol Chem (2007) 282, 6153-6160. PubMed  Europe PubMed DOI
  55. Chen,M., Fu,Y.Y., Lin,C.Y., Chen,L.M. and Chai,K.X.
    Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3
    Biochim Biophys Acta (2007) 1773, 1133-1140. PubMed  Europe PubMed DOI  PMC  EPMC
  56. List,K., Hobson,J.P., Molinolo,A. and Bugge,T.H.
    Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase
    J Cell Physiol (2007) 213, 237-245. PubMed  Europe PubMed DOI
  57. Planes,C. and Caughey,G.H.
    Regulation of the epithelial Na+ channel by peptidases
    Curr Top Dev Biol (2007) 78, 23-46. PubMed  Europe PubMed DOI  PMC  EPMC
    58. 2006
  58. [YEAR:8-3-2006]Andreasen,D., Vuagniaux,G., Fowler-Jaeger,N., Hummler,E. and Rossier,B.C.
    Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1
    J Am Soc Nephrol (8-3-2006) 17, 968-976. PubMed  Europe PubMed DOI
  59. [YEAR:11-8-2006]Chen,M., Chen,L.M. and Chai,K.X.
    Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression
    Biochem Biophys Res Commun (11-8-2006) 346, 1245-1253. PubMed  Europe PubMed DOI
  60. Kleyman,T.R., Myerburg,M.M. and Hughey,R.P.
    Regulation of ENaCs by proteases: an increasingly complex story
    Kidney Int (2006) 70, 1391-1392. PubMed  Europe PubMed DOI
  61. [YEAR:26-6-2006]Lin,H.Y., Zhang,H., Yang,Q., Wang,H.X., Wang,H.M., Chai,K.X., Chen,L.M. and Zhu,C.
    Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy
    J Histochem Cytochem (26-6-2006) 54, 1139-1147. PubMed  Europe PubMed DOI
  62. [YEAR:15-9-2006]Netzel-Arnett,S., Currie,B.M., Szabo,R., Lin,C.Y., Chen,L.M., Chai,K.X., Antalis,T.M., Bugge,T.H. and List,K.
    Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation
    J Biol Chem (15-9-2006) 281, 32941-32945. PubMed  Europe PubMed DOI
  63. [YEAR:5-7-2006]Verghese,G.M., Gutknecht,M.F. and Caughey,G.H.
    Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor
    Am J Physiol Cell Physiol (5-7-2006) 291, C1258-C1270. PubMed  Europe PubMed DOI  PMC  EPMC
    64. 2005
  64. [YEAR:1-8-2005]Leyvraz,C., Charles,R.P., Rubera,I., Guitard,M., Rotman,S., Breiden,B., Sandhoff,K. and Hummler,E.
    The epidermal barrier function is dependent on the serine protease CAP1/Prss8
    J Cell Biol (1-8-2005) 170, 487-496. PubMed  Europe PubMed DOI  PMC  EPMC  K
  65. Olivieri,O., Castagna,A., Guarini,P., Chiecchi,L., Sabaini,G., Pizzolo,F., Corrocher,R. and Righetti,P.G.
    Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans
    Hypertension (2005) 46, 683-688. PubMed  Europe PubMed DOI
    66. 2004
  66. [YEAR:10-9-2004]Caldwell,R.A., Boucher,R.C. and Stutts,M.J.
    Serine protease activation of near-silent epithelial Na+ channels
    Am J Physiol Cell Physiol (10-9-2004) 286, C190-C194. PubMed  Europe PubMed DOI
  67. Chao,J.
    Prostasin
    [ISSN:0-12-079610-4] (2004) 2, 1708-1709.  V
  68. Chen,L.M., Zhang,X. and Chai,K.X.
    Regulation of prostasin expression and function in the prostate
    Prostate (2004) 59, 1-12. PubMed  Europe PubMed DOI
  69. [YEAR:12-11-2004]Shipway,A., Danahay,H., Williams,J.A., Tully,D.C., Backes,B.J. and Harris,J.L.
    Biochemical characterization of prostasin, a channel activating protease
    Biochem Biophys Res Commun (12-11-2004) 324, 953-963. PubMed  Europe PubMed DOI
  70. [YEAR:9-7-2004]Tong,Z., Illek,B., Bhagwandin,V.J., Verghese,G.M. and Caughey,G.H.
    Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line
    Am J Physiol Lung Cell Mol Physiol (9-7-2004) 287, L928-L935. PubMed  Europe PubMed DOI
  71. Verghese,G.M., Tong,Z.Y., Bhagwandin,V. and Caughey,G.H.
    Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney
    Am J Respir Cell Mol Biol (2004) 30, 519-529. PubMed  Europe PubMed DOI
    72. 2003
  72. Iwashita,K., Kitamura,K., Narikiyo,T., Adachi,M., Shiraishi,N., Miyoshi,T., Nagano,J., Tuyen,D.G., Nonoguchi,H. and Tomita,K.
    Inhibition of prostasin secretion by serine protease inhibitors in the kidney
    J Am Soc Nephrol (2003) 14, 11-16. PubMed  Europe PubMed DOI  I
  73. Wang,C., Chao,J. and Chao,L.
    Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats
    Am J Physiol Regul Integr Comp Physiol (2003) 284, R1031-R1036. PubMed  Europe PubMed DOI  U
    74. 2002
  74. [YEAR:20-1-2002]Chen,L.M. and Chai,K.X.
    Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation
    Int J Cancer (20-1-2002) 97, 323-329. PubMed  Europe PubMed DOI
  75. [YEAR:8-3-2002]Donaldson,S.H., Hirsh,A., Li,D.C., Holloway,G., Chao,J., Boucher,R.C. and Gabriel,S.E.
    Regulation of the epithelial sodium channel by serine proteases in human airways
    J Biol Chem (8-3-2002) 277, 8338-8345. PubMed  Europe PubMed DOI
  76. Rubera,I., Meier,E., Vuagniaux,G., Merillat,A.M., Beermann,F., Rossier,B.C. and Hummler,E.
    A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus
    Genesis (2002) 32, 173-176. PubMed  Europe PubMed DOI
  77. Vallet,V., Pfister,C., Loffing,J. and Rossier,B.C.
    Cell-surface expression of the channel activating protease xCAP-1 is required for activation of ENaC in the Xenopus oocyte
    J Am Soc Nephrol (2002) 13, 588-594. PubMed  Europe PubMed
  78. Vuagniaux,G., Vallet,V., Jaeger,N.F., Hummler,E. and Rossier,B.C.
    Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes
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