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Literature for peptidase S01.159: prostasin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Mizoo,T., Oka,T., Sugahara,O., Minato,T., Higa,T. and Nakayama,K.I.
    GPLD1+ cancer stem cells contribute to chemotherapy resistance and tumor relapse in intestinal cancer
    J Biochem PubMed  Europe PubMed DOI
    2. 2023
  2. Ehret,E., Stroh,S., Auberson,M., Ino,F., Jager,Y., Maillard,M., Szabo,R., Bugge,T.H., Frateschi,S. and Hummler,E.
    Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
    Cells12, PubMed  Europe PubMed DOI
  3. Shamseldin,H.E., Derar,N., Alzaidan,H., AlHathal,N., Alfalah,A., Abdulwahab,F., Alzaid,T., Alkeraye,S., Alobaida,S.A. and Alkuraya,F.S.
    PRSS8, encoding prostasin, is mutated in patients with autosomal recessive ichthyosis
    Hum Genet142, 477-482. PubMed  Europe PubMed DOI
    4. 2021
  4. Essigke,D., Ilyaskin,A.V., Worn,M., Bohnert,B.N., Xiao,M., Daniel,C., Amann,K., Birkenfeld,A.L., Szabo,R., Bugge,T.H., Korbmacher,C. and Artunc,F.
    Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice
    Acta Physiol (Oxf)e13640-e13640. PubMed  Europe PubMed DOI
  5. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
    Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  6. Frindt,G., Shi,S., Kleyman,T.R. and Palmer,L.G.
    Cleavage state of gammaENaC in mouse and rat kidney
    Am J Physiol Renal Physiol PubMed  Europe PubMed DOI
    7. 2020
  7. Chang,S.C., Chiang,C.P., Lai,C.H., Du,P.A., Hung,Y.S., Chen,Y.H., Yang,H.Y., Fang,H.Y., Lee,S.P., Tang,H.J., Wang,J.K., Johnson,M.D. and Lin,C.Y.
    Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin
    Hum Cell PubMed  Europe PubMed DOI
  8. Ejaz,S., Ali,A., Azim,K., Mahmood,A., Khan,A.I., Almazyad,T.A. and Bilal,B.
    Association between preeclampsia and prostasin polymorphism in Pakistani females
    Saudi Med J41, 1234-1240. PubMed  Europe PubMed DOI
  9. Holt-Danborg,L., Skovbjerg,S., Goderum,K.W., Nonboe,A.W., Stankevic,E., Frost,A.K., Vitved,L., Jensen,J.K. and Vogel,L.K.
    Insights into the regulation of the matriptase-prostasin proteolytic system
    Biochem J PubMed  Europe PubMed DOI
  10. Murray,A.S., Hyland,T.E., Sala-Hamrick,K.E., Mackinder,J.R., Martin,C.E., Tanabe,L.M., Varela,F.A. and List,K.
    The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy
    Oncogene PubMed  Europe PubMed DOI  K
    11. 2019
  11. Bao,Y., Guo,Y., Yang,Y., Wei,X., Zhang,S., Zhang,Y., Li,K., Yuan,M., Guo,D., Macias,V., Zhu,X., Zhang,W. and Yang,W.
    PRSS8 suppresses colorectal carcinogenesis and metastasis
    Oncogene38, 497-517. PubMed  Europe PubMed DOI  K
  12. Lin,C.K., Tseng,C.K., Wu,Y.H., Lin,C.Y., Huang,C.H., Wang,W.H., Liaw,C.C., Chen,Y.H. and Lee,J.C.
    Prostasin impairs epithelial growth factor receptor activation to suppress dengue virus propagation
    J Infect Dis219, 1377-1388. PubMed  Europe PubMed DOI
    13. 2018
  13. Szabo,R. and Bugge,T.H.
    Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy
    PLoS ONE13, e0194660-e0194660. PubMed  Europe PubMed DOI  M
    14. 2017
  14. Shiao,F., Liu,L.O., Huang,N., Lai,Y.J., Barndt,R.J., Tseng,C.C., Wang,J.K., Jia,B., Johnson,M.D. and Lin,C.Y.
    Selective inhibition of prostasin in human enterocytes by the integral membrane Kunitz-type serine protease inhibitor HAI-2
    PLoS ONE12, e0170944-e0170944. PubMed  Europe PubMed DOI
    15. 2016
  15. Friis,S., Madsen,D.H. and Bugge,T.H.
    Distinct developmental functions of prostasin (CAP1/PRSS8) zymogen and activated prostasin
    J Biol Chem291, 2577-2582. PubMed  Europe PubMed DOI
  16. Hou,J.
    Paracellular transport in the collecting duct
    Curr Opin Nephrol Hypertens25, 424-428. PubMed  Europe PubMed DOI
  17. Su,H.C., Liang,Y.A., Lai,Y.J., Chiu,Y.L., Barndt,R.B., Shiao,F., Chang,H.D., Lu,D.D., Huang,N., Tseng,C.C., Wang,J.K., Lee,M.S., Johnson,M.D., Huang,S.M. and Lin,C.Y.
    Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner
    PLoS ONE11, e0167894-e0167894. PubMed  Europe PubMed DOI
  18. Szabo,R., Lantsman,T., Peters,D.E. and Bugge,T.H.
    Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin
    Development143, 2818-2828. PubMed  Europe PubMed DOI  K
    19. 2015
  19. Uchimura,K. and Kitamura,K.
    [Prostasin (PRSS8) as a new pathological factor]
    Nihon Rinsho73, 523-533. PubMed  Europe PubMed
    20. 2014
  20. Carattino,M.D., Mueller,G.M., Palmer,L.G., Frindt,G., Rued,A.C., Hughey,R.P. and Kleyman,T.R.
    Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the gamma-subunit by a second protease
    Am J Physiol Renal Physiol307, F1080-F1087. PubMed  Europe PubMed DOI
  21. Crisante,G., Battista,L., Iwaszkiewicz,J., Nesca,V., Merillat,A.-M., Sergi,C., Zoete,V., Frateschi,S. and Hummler,E.
    The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition
    FASEB J28, 4792-4805. PubMed  Europe PubMed DOI
  22. Friis,S., Sales,K.U., Schafer,J.M., Vogel,L.K., Kataoka,H. and Bugge,T.H.
    The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin
    J Biol Chem289, 22319-22332. PubMed  Europe PubMed DOI
  23. Hamilton,K.L.
    Cleavage: what's up with prostasin AND ENaC these days?
    Am J Physiol Renal Physiol307, F1196-F1197. PubMed  Europe PubMed DOI
  24. Peters,D.E., Szabo,R., Friis,S., Shylo,N.A., Uzzun Sales,K., Holmbeck,K. and Bugge,T.H.
    The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity
    J Biol Chem289, 14740-14749. PubMed  Europe PubMed DOI
  25. Uchimura,K., Hayata,M., Mizumoto,T., Miyasato,Y., Kakizoe,Y., Morinaga,J., Onoue,T., Yamazoe,R., Ueda,M., Adachi,M., Miyoshi,T., Shiraishi,N., Ogawa,W., Fukuda,K., Kondo,T., Matsumura,T., Araki,E., Tomita,K. and Kitamura,K.
    The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling
    Nat Commun5, 3428-3428. PubMed  Europe PubMed DOI  K
    26. 2013
  26. Buzza,M.S., Martin,E.W., Driesbaugh,K.H., Desilets,A., Leduc,R. and Antalis,T.M.
    Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway
    J Biol Chem288, 10328-10337. PubMed  Europe PubMed DOI
  27. Friis,S., Uzzun Sales,K., Godiksen,S., Peters,D.E., Lin,C.Y., Vogel,L.K. and Bugge,T.H.
    A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation
    J Biol Chem288, 19028-19039. PubMed  Europe PubMed DOI
  28. Hummler,E., Dousse,A., Rieder,A., Stehle,J.C., Rubera,I., Osterheld,M.C., Beermann,F., Frateschi,S. and Charles,R.P.
    The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation
    PLoS ONE8, e55796-e55796. PubMed  Europe PubMed DOI  K
  29. Miller,G.S. and List,K.
    The matriptase-prostasin proteolytic cascade in epithelial development and pathology
    Cell Tissue Res351, 245-253. PubMed  Europe PubMed DOI
  30. Rowe,S.M., Reeves,G., Hathorne,H., Solomon,G.M., Abbi,S., Renard,D., Lock,R., Zhou,P., Danahay,H., Clancy,J.P. and Waltz,D.A.
    Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis
    Chest144, 200-207. PubMed  Europe PubMed DOI  I
    31. 2012
  31. Bergum,C., Zoratti,G., Boerner,J. and List,K.
    Strong expression association between matriptase and its substrate prostasin in breast cancer
    J Cell Physiol227, 1604-1609. PubMed  Europe PubMed DOI
  32. Chao,J., Chen,L.M. and Chai,K.X.
    Prostasin
    [ISSN:978-0-12-407742-3]3, 3011-3014. DOI
  33. Frateschi,S., Keppner,A., Malsure,S., Iwaszkiewicz,J., Sergi,C., Merillat,A.M., Fowler-Jaeger,N., Randrianarison,N., Planes,C. and Hummler,E.
    Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity
    Am J Pathol181, 605-615. PubMed  Europe PubMed DOI  M
  34. Kitamura,K. and Tomita,K.
    Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension
    Clin Exp Nephrol16, 44-48. PubMed  Europe PubMed DOI  I
  35. Szabo,R., Uzzun Sales,K., Kosa,P., Shylo,N.A., Godiksen,S., Hansen,K.K., Friis,S., Gutkind,J.S., Vogel,L.K., Hummler,E., Camerer,E. and Bugge,T.H.
    Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation
    PLoS Genet8, e1002937-e1002937. PubMed  Europe PubMed DOI
    36. 2011
  36. Antalis,T.M., Bugge,T.H. and Wu,Q.
    Membrane-anchored serine proteases in health and disease
    Prog Mol Biol Transl Sci99, 1-50. PubMed  Europe PubMed DOI  V
  37. Xu,Z., Chen,Y.W., Battu,A., Wilder,P., Weber,D., Yu,W., Mackerell,A.D., Chen,L.M., Chai,K.X., Johnson,M.D. and Lin,C.Y.
    Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade
    J Med Chem54, 7567-7578. PubMed  Europe PubMed DOI  I
    38. 2010
  38. Camerer,E., Barker,A., Duong,D.N., Ganesan,R., Kataoka,H., Cornelissen,I., Darragh,M.R., Hussain,A., Zheng,Y.W., Srinivasan,Y., Brown,C., Xu,S.M., Regard,J.B., Lin,C.Y., Craik,C.S., Kirchhofer,D. and Coughlin,S.R.
    Local protease signaling contributes to neural tube closure in the mouse embryo
    Dev Cell18, 25-38. PubMed  Europe PubMed DOI
  39. Chen,Y.W., Wang,J.K., Chou,F.P., Chen,C.Y., Rorke,E.A., Chen,L.M., Chai,K.X., Eckert,R.L., Johnson,M.D. and Lin,C.Y.
    Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation
    J Biol Chem285, 31755-31762. PubMed  Europe PubMed DOI
  40. Fu,Y.Y., Gao,W.L., Chen,M., Chai,K.X., Wang,Y.L. and Chen,L.M.
    Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway
    Hum Reprod25, 623-632. PubMed  Europe PubMed DOI
  41. Ko,T., Kakizoe,Y., Wakida,N., Hayata,M., Uchimura,K., Shiraishi,N., Miyoshi,T., Adachi,M., Aritomi,S., Konda,T., Tomita,K. and Kitamura,K.
    Regulation of adrenal aldosterone production by serine protease prostasin
    J Biomed Biotechnol2010, 793843-793843. PubMed  Europe PubMed DOI  I
  42. Planes,C., Randrianarison,N.H., Charles,R.P., Frateschi,S., Cluzeaud,F., Vuagniaux,G., Soler,P., Clerici,C., Rossier,B.C. and Hummler,E.
    ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1
    EMBO Mol Med2, 26-37. PubMed  Europe PubMed DOI  K
  43. Spacek,D.V., Perez,A.F., Ferranti,K.M., Wu,L.K., Moy,D.M., Magnan,D.R. and King,T.R.
    The mouse frizzy (fr) and rat 'hairless' (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8)
    Exp Dermatol19, 527-532. PubMed  Europe PubMed DOI  M
    44. 2009
  44. Chen,L.M., Hatfield,M.L., Fu,Y.Y. and Chai,K.X.
    Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells
    Prostate69, 1790-1801. PubMed  Europe PubMed DOI
  45. Ma,X.J., Fu,Y.Y., Li,Y.X., Chen,L.M., Chai,K. and Wang,Y.L.
    Prostasin inhibits cell invasion in human choriocarcinomal JEG-3 cells
    Histochem Cell Biol132, 639-646. PubMed  Europe PubMed DOI
  46. Spraggon,G., Hornsby,M., Shipway,A., Tully,D.C., Bursulaya,B., Danahay,H., Harris,J.L. and Lesley,S.A.
    Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations
    Protein Sci18, 1081-1094. PubMed  Europe PubMed DOI  S
  47. Svenningsen,P., Uhrenholt,T.R., Palarasah,Y., Skjodt,K., Jensen,B.L. and Skott,O.
    Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations
    Am J Physiol Regul Integr Comp Physiol297, R1733-R1741. PubMed  Europe PubMed DOI
    48. 2008
  48. Chen,M., Chen,L.M., Lin,C.Y. and Chai,K.X.
    The epidermal growth factor receptor (EGFR) is proteolytically modified by the matriptase-prostasin serine protease cascade in cultured epithelial cells
    Biochim Biophys Acta1783, 896-903. PubMed  Europe PubMed DOI
  49. Rickert,K.W., Kelley,P., Byrne,N.J., Diehl,R.E., Hall,D.L., Montalvo,A.M., Reid,J.C., Shipman,J.M., Thomas,B.W., Munshi,S.K., Darke,P.L. and Su,H.P.
    Structure of human prostasin, a target for the regulation of hypertension
    J Biol Chem283, 34864-34872. PubMed  Europe PubMed DOI  S
  50. Tully,D.C., Vidal,A., Chatterjee,A.K., Williams,J.A., Roberts,M.J., Petrassi,H.M., Spraggon,G., Bursulaya,B., Pacoma,R., Shipway,A., Schumacher,A.M., Danahay,H. and Harris,J.L.
    Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design
    Bioorg Med Chem Lett18, 5895-5899. PubMed  Europe PubMed DOI  S  I
  51. Zhu,H., Guo,D., Li,K., Yan,W., Tan,Y., Wang,X., Treiber,F.A., Chao,J., Snieder,H. and Dong,Y.
    Prostasin: a possible candidate gene for human hypertension
    Am J Hypertens21, 1028-1033. PubMed  Europe PubMed DOI
    52. 2007
  52. Bruns,J.B., Carattino,M.D., Sheng,S., Maarouf,A.B., Weisz,O.A., Pilewski,J.M., Hughey,R.P. and Kleyman,T.R.
    Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit
    J Biol Chem282, 6153-6160. PubMed  Europe PubMed DOI
  53. Chen,M., Fu,Y.Y., Lin,C.Y., Chen,L.M. and Chai,K.X.
    Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3
    Biochim Biophys Acta1773, 1133-1140. PubMed  Europe PubMed DOI
  54. List,K., Hobson,J.P., Molinolo,A. and Bugge,T.H.
    Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase
    J Cell Physiol213, 237-245. PubMed  Europe PubMed DOI
  55. Planes,C. and Caughey,G.H.
    Regulation of the epithelial Na+ channel by peptidases
    Curr Top Dev Biol78, 23-46. PubMed  Europe PubMed DOI
    56. 2006
  56. [YEAR:8-3-2006]Andreasen,D., Vuagniaux,G., Fowler-Jaeger,N., Hummler,E. and Rossier,B.C.
    Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1
    J Am Soc Nephrol17, 968-976. PubMed  Europe PubMed DOI
  57. [YEAR:11-8-2006]Chen,M., Chen,L.M. and Chai,K.X.
    Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression
    Biochem Biophys Res Commun346, 1245-1253. PubMed  Europe PubMed DOI
  58. Kleyman,T.R., Myerburg,M.M. and Hughey,R.P.
    Regulation of ENaCs by proteases: an increasingly complex story
    Kidney Int70, 1391-1392. PubMed  Europe PubMed DOI
  59. [YEAR:26-6-2006]Lin,H.Y., Zhang,H., Yang,Q., Wang,H.X., Wang,H.M., Chai,K.X., Chen,L.M. and Zhu,C.
    Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy
    J Histochem Cytochem54, 1139-1147. PubMed  Europe PubMed DOI
  60. [YEAR:15-9-2006]Netzel-Arnett,S., Currie,B.M., Szabo,R., Lin,C.Y., Chen,L.M., Chai,K.X., Antalis,T.M., Bugge,T.H. and List,K.
    Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation
    J Biol Chem281, 32941-32945. PubMed  Europe PubMed DOI
  61. [YEAR:5-7-2006]Verghese,G.M., Gutknecht,M.F. and Caughey,G.H.
    Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor
    Am J Physiol Cell Physiol291, C1258-C1270. PubMed  Europe PubMed DOI
    62. 2005
  62. [YEAR:1-8-2005]Leyvraz,C., Charles,R.P., Rubera,I., Guitard,M., Rotman,S., Breiden,B., Sandhoff,K. and Hummler,E.
    The epidermal barrier function is dependent on the serine protease CAP1/Prss8
    J Cell Biol170, 487-496. PubMed  Europe PubMed DOI  K
  63. Olivieri,O., Castagna,A., Guarini,P., Chiecchi,L., Sabaini,G., Pizzolo,F., Corrocher,R. and Righetti,P.G.
    Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans
    Hypertension46, 683-688. PubMed  Europe PubMed DOI
    64. 2004
  64. [YEAR:10-9-2004]Caldwell,R.A., Boucher,R.C. and Stutts,M.J.
    Serine protease activation of near-silent epithelial Na+ channels
    Am J Physiol Cell Physiol286, C190-C194. PubMed  Europe PubMed DOI
  65. Chao,J.
    Prostasin
    [ISSN:0-12-079610-4]2, 1708-1709.  V
  66. Chen,L.M., Zhang,X. and Chai,K.X.
    Regulation of prostasin expression and function in the prostate
    Prostate59, 1-12. PubMed  Europe PubMed DOI
  67. [YEAR:12-11-2004]Shipway,A., Danahay,H., Williams,J.A., Tully,D.C., Backes,B.J. and Harris,J.L.
    Biochemical characterization of prostasin, a channel activating protease
    Biochem Biophys Res Commun324, 953-963. PubMed  Europe PubMed DOI
  68. [YEAR:9-7-2004]Tong,Z., Illek,B., Bhagwandin,V.J., Verghese,G.M. and Caughey,G.H.
    Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line
    Am J Physiol Lung Cell Mol Physiol287, L928-L935. PubMed  Europe PubMed DOI
  69. Verghese,G.M., Tong,Z.Y., Bhagwandin,V. and Caughey,G.H.
    Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney
    Am J Respir Cell Mol Biol30, 519-529. PubMed  Europe PubMed DOI
    70. 2003
  70. Iwashita,K., Kitamura,K., Narikiyo,T., Adachi,M., Shiraishi,N., Miyoshi,T., Nagano,J., Tuyen,D.G., Nonoguchi,H. and Tomita,K.
    Inhibition of prostasin secretion by serine protease inhibitors in the kidney
    J Am Soc Nephrol14, 11-16. PubMed  Europe PubMed DOI  I
  71. Wang,C., Chao,J. and Chao,L.
    Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats
    Am J Physiol Regul Integr Comp Physiol284, R1031-R1036. PubMed  Europe PubMed DOI  U
    72. 2002
  72. [YEAR:20-1-2002]Chen,L.M. and Chai,K.X.
    Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation
    Int J Cancer97, 323-329. PubMed  Europe PubMed DOI
  73. [YEAR:8-3-2002]Donaldson,S.H., Hirsh,A., Li,D.C., Holloway,G., Chao,J., Boucher,R.C. and Gabriel,S.E.
    Regulation of the epithelial sodium channel by serine proteases in human airways
    J Biol Chem277, 8338-8345. PubMed  Europe PubMed DOI
  74. Rubera,I., Meier,E., Vuagniaux,G., Merillat,A.M., Beermann,F., Rossier,B.C. and Hummler,E.
    A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus
    Genesis32, 173-176. PubMed  Europe PubMed DOI
  75. Vallet,V., Pfister,C., Loffing,J. and Rossier,B.C.
    Cell-surface expression of the channel activating protease xCAP-1 is required for activation of ENaC in the Xenopus oocyte
    J Am Soc Nephrol13, 588-594. PubMed  Europe PubMed
  76. Vuagniaux,G., Vallet,V., Jaeger,N.F., Hummler,E. and Rossier,B.C.
    Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes
    J Gen Physiol120, 191-201. PubMed  Europe PubMed DOI
    77. 2001
  77. Adachi,M., Kitamura,K., Miyoshi,T., Narikiyo,T., Iwashita,K., Shiraishi,N., Nonoguchi,H. and Tomita,K.
    Activation of epithelial sodium channels by prostasin in Xenopus oocytes
    J Am Soc Nephrol12, 1114-1121. PubMed  Europe PubMed
  78. Bridges,R.J., Newton,B.B., Pilewski,J.M., Devor,D.C., Poll,C.T. and Hall,R.L.
    Na+ transport in normal and CF human bronchial epithelial cells is inhibited by BAY 39-9437
    Am J Physiol Lung Cell Mol Physiol281, L16-L23. PubMed  Europe PubMed
  79. [YEAR:15-6-2001]Chen,L.M., Skinner,M.L., Kauffman,S.W., Chao,J., Chao,L., Thaler,C.D. and Chai,K.X.
    Prostasin is a glycosylphosphatidylinositol-anchored active serine protease
    J Biol Chem276, 21434-21442. PubMed  Europe PubMed DOI
  80. [YEAR:1-7-2001]Chen,L.M., Hodge,G.B., Guarda,L.A., Welch,J.L., Greenberg,N.M. and Chai,K.X.
    Down-regulation of prostasin serine protease: A potential invasion suppressor in prostate cancer
    Prostate48, 93-103. PubMed  Europe PubMed DOI
  81. Laribi,A., Berteau,P., Gala,J., Eschwege,P., Benoit,G., Tombal,B., Schmitt,F. and Loric,S.
    Blood-borne RT-PCR assay for prostasin-specific transcripts to identify circulating prostate cells in cancer patients
    Eur Urol39, 65-71. PubMed  Europe PubMed DOI
  82. [YEAR:3-10-2001]Mok,S.C., Chao,J., Skates,S., Wong,K., Yiu,G.K., Muto,M.G., Berkowitz,R.S. and Cramer,D.W.
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