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Literature for peptidase S01.159: prostasin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,H., Zhang,L., Zhang,L., Liu,T., Pang,X., Fan,C. and Jiang,H.<br>m6A Modification Destabilizes Prss8 and Activates Hepatic Stellate Cells via TLR4-Mediated Inflammatory Responses<br>DNA Cell Biol (2025) PubMed  Europe PubMed DOI
  2. Mizoo,T., Oka,T., Sugahara,O., Minato,T., Higa,T. and Nakayama,K.I.<br>GPLD1+ cancer stem cells contribute to chemotherapy resistance and tumor relapse in intestinal cancer<br>J Biochem (2025) PubMed  Europe PubMed DOI
  3. Ren,H., Zhao,T., Lv,Z., Xie,G. and Sun,H.<br>Prospective association of the triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio with anxiety risk in a community-based cohort: a UK Biobank study<br>BMJ Open (2025) 15, e103997-e103997. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2023
  4. Ehret,E., Stroh,S., Auberson,M., Ino,F., Jager,Y., Maillard,M., Szabo,R., Bugge,T.H., Frateschi,S. and Hummler,E.<br>Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity<br>Cells (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Shamseldin,H.E., Derar,N., Alzaidan,H., AlHathal,N., Alfalah,A., Abdulwahab,F., Alzaid,T., Alkeraye,S., Alobaida,S.A. and Alkuraya,F.S.<br>PRSS8, encoding prostasin, is mutated in patients with autosomal recessive ichthyosis<br>Hum Genet (2023) 142, 477-482. PubMed  Europe PubMed DOI
    6. 2021
  6. Essigke,D., Ilyaskin,A.V., Worn,M., Bohnert,B.N., Xiao,M., Daniel,C., Amann,K., Birkenfeld,A.L., Szabo,R., Bugge,T.H., Korbmacher,C. and Artunc,F.<br>Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice<br>Acta Physiol (Oxf) (2021) , e13640-e13640. PubMed  Europe PubMed DOI
  7. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.<br>Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2<br>Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Frindt,G., Shi,S., Kleyman,T.R. and Palmer,L.G.<br>Cleavage state of gammaENaC in mouse and rat kidney<br>Am J Physiol Renal Physiol (2021) PubMed  Europe PubMed DOI
    9. 2020
  9. Chang,S.C., Chiang,C.P., Lai,C.H., Du,P.A., Hung,Y.S., Chen,Y.H., Yang,H.Y., Fang,H.Y., Lee,S.P., Tang,H.J., Wang,J.K., Johnson,M.D. and Lin,C.Y.<br>Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin<br>Hum Cell (2020) PubMed  Europe PubMed DOI
  10. Ejaz,S., Ali,A., Azim,K., Mahmood,A., Khan,A.I., Almazyad,T.A. and Bilal,B.<br>Association between preeclampsia and prostasin polymorphism in Pakistani females<br>Saudi Med J (2020) 41, 1234-1240. PubMed  Europe PubMed DOI
  11. Holt-Danborg,L., Skovbjerg,S., Goderum,K.W., Nonboe,A.W., Stankevic,E., Frost,A.K., Vitved,L., Jensen,J.K. and Vogel,L.K.<br>Insights into the regulation of the matriptase-prostasin proteolytic system<br>Biochem J (2020) PubMed  Europe PubMed DOI
  12. Murray,A.S., Hyland,T.E., Sala-Hamrick,K.E., Mackinder,J.R., Martin,C.E., Tanabe,L.M., Varela,F.A. and List,K.<br>The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy<br>Oncogene (2020) PubMed  Europe PubMed DOI  K
    13. 2019
  13. Bao,Y., Guo,Y., Yang,Y., Wei,X., Zhang,S., Zhang,Y., Li,K., Yuan,M., Guo,D., Macias,V., Zhu,X., Zhang,W. and Yang,W.<br>PRSS8 suppresses colorectal carcinogenesis and metastasis<br>Oncogene (2019) 38, 497-517. PubMed  Europe PubMed DOI  K
  14. Lin,C.K., Tseng,C.K., Wu,Y.H., Lin,C.Y., Huang,C.H., Wang,W.H., Liaw,C.C., Chen,Y.H. and Lee,J.C.<br>Prostasin impairs epithelial growth factor receptor activation to suppress dengue virus propagation<br>J Infect Dis (2019) 219, 1377-1388. PubMed  Europe PubMed DOI
    15. 2018
  15. Szabo,R. and Bugge,T.H.<br>Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy<br>PLoS ONE (2018) 13, e0194660-e0194660. PubMed  Europe PubMed DOI  M
    16. 2017
  16. Shiao,F., Liu,L.O., Huang,N., Lai,Y.J., Barndt,R.J., Tseng,C.C., Wang,J.K., Jia,B., Johnson,M.D. and Lin,C.Y.<br>Selective inhibition of prostasin in human enterocytes by the integral membrane Kunitz-type serine protease inhibitor HAI-2<br>PLoS ONE (2017) 12, e0170944-e0170944. PubMed  Europe PubMed DOI
    17. 2016
  17. Friis,S., Madsen,D.H. and Bugge,T.H.<br>Distinct developmental functions of prostasin (CAP1/PRSS8) zymogen and activated prostasin<br>J Biol Chem (2016) 291, 2577-2582. PubMed  Europe PubMed DOI
  18. Hou,J.<br>Paracellular transport in the collecting duct<br>Curr Opin Nephrol Hypertens (2016) 25, 424-428. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Su,H.C., Liang,Y.A., Lai,Y.J., Chiu,Y.L., Barndt,R.B., Shiao,F., Chang,H.D., Lu,D.D., Huang,N., Tseng,C.C., Wang,J.K., Lee,M.S., Johnson,M.D., Huang,S.M. and Lin,C.Y.<br>Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner<br>PLoS ONE (2016) 11, e0167894-e0167894. PubMed  Europe PubMed DOI
  20. Szabo,R., Lantsman,T., Peters,D.E. and Bugge,T.H.<br>Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin<br>Development (2016) 143, 2818-2828. PubMed  Europe PubMed DOI  K
    21. 2015
  21. Uchimura,K. and Kitamura,K.<br>[Prostasin (PRSS8) as a new pathological factor]<br>Nihon Rinsho (2015) 73, 523-533. PubMed  Europe PubMed
    22. 2014
  22. Carattino,M.D., Mueller,G.M., Palmer,L.G., Frindt,G., Rued,A.C., Hughey,R.P. and Kleyman,T.R.<br>Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the gamma-subunit by a second protease<br>Am J Physiol Renal Physiol (2014) 307, F1080-F1087. PubMed  Europe PubMed DOI
  23. Crisante,G., Battista,L., Iwaszkiewicz,J., Nesca,V., Merillat,A.-M., Sergi,C., Zoete,V., Frateschi,S. and Hummler,E.<br>The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition<br>FASEB J (2014) 28, 4792-4805. PubMed  Europe PubMed DOI
  24. Friis,S., Sales,K.U., Schafer,J.M., Vogel,L.K., Kataoka,H. and Bugge,T.H.<br>The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin<br>J Biol Chem (2014) 289, 22319-22332. PubMed  Europe PubMed DOI
  25. Hamilton,K.L.<br>Cleavage: what's up with prostasin AND ENaC these days?<br>Am J Physiol Renal Physiol (2014) 307, F1196-F1197. PubMed  Europe PubMed DOI
  26. Peters,D.E., Szabo,R., Friis,S., Shylo,N.A., Uzzun Sales,K., Holmbeck,K. and Bugge,T.H.<br>The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity<br>J Biol Chem (2014) 289, 14740-14749. PubMed  Europe PubMed DOI
  27. Uchimura,K., Hayata,M., Mizumoto,T., Miyasato,Y., Kakizoe,Y., Morinaga,J., Onoue,T., Yamazoe,R., Ueda,M., Adachi,M., Miyoshi,T., Shiraishi,N., Ogawa,W., Fukuda,K., Kondo,T., Matsumura,T., Araki,E., Tomita,K. and Kitamura,K.<br>The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling<br>Nat Commun (2014) 5, 3428-3428. PubMed  Europe PubMed DOI  PMC  EPMC  K
    28. 2013
  28. Buzza,M.S., Martin,E.W., Driesbaugh,K.H., Desilets,A., Leduc,R. and Antalis,T.M.<br>Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway<br>J Biol Chem (2013) 288, 10328-10337. PubMed  Europe PubMed DOI
  29. Friis,S., Uzzun Sales,K., Godiksen,S., Peters,D.E., Lin,C.Y., Vogel,L.K. and Bugge,T.H.<br>A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation<br>J Biol Chem (2013) 288, 19028-19039. PubMed  Europe PubMed DOI
  30. Hummler,E., Dousse,A., Rieder,A., Stehle,J.C., Rubera,I., Osterheld,M.C., Beermann,F., Frateschi,S. and Charles,R.P.<br>The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation<br>PLoS ONE (2013) 8, e55796-e55796. PubMed  Europe PubMed DOI  PMC  EPMC  K
  31. Miller,G.S. and List,K.<br>The matriptase-prostasin proteolytic cascade in epithelial development and pathology<br>Cell Tissue Res (2013) 351, 245-253. PubMed  Europe PubMed DOI
  32. Rowe,S.M., Reeves,G., Hathorne,H., Solomon,G.M., Abbi,S., Renard,D., Lock,R., Zhou,P., Danahay,H., Clancy,J.P. and Waltz,D.A.<br>Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis<br>Chest (2013) 144, 200-207. PubMed  Europe PubMed DOI  I
    33. 2012
  33. Bergum,C., Zoratti,G., Boerner,J. and List,K.<br>Strong expression association between matriptase and its substrate prostasin in breast cancer<br>J Cell Physiol (2012) 227, 1604-1609. PubMed  Europe PubMed DOI
  34. Chao,J., Chen,L.M. and Chai,K.X.<br>Prostasin<br>[ISSN:978-0-12-407742-3] (2012) 3, 3011-3014. DOI
  35. Frateschi,S., Keppner,A., Malsure,S., Iwaszkiewicz,J., Sergi,C., Merillat,A.M., Fowler-Jaeger,N., Randrianarison,N., Planes,C. and Hummler,E.<br>Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity<br>Am J Pathol (2012) 181, 605-615. PubMed  Europe PubMed DOI  M
  36. Kitamura,K. and Tomita,K.<br>Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension<br>Clin Exp Nephrol (2012) 16, 44-48. PubMed  Europe PubMed DOI  I
  37. Szabo,R., Uzzun Sales,K., Kosa,P., Shylo,N.A., Godiksen,S., Hansen,K.K., Friis,S., Gutkind,J.S., Vogel,L.K., Hummler,E., Camerer,E. and Bugge,T.H.<br>Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation<br>PLoS Genet (2012) 8, e1002937-e1002937. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2011
  38. Antalis,T.M., Bugge,T.H. and Wu,Q.<br>Membrane-anchored serine proteases in health and disease<br>Prog Mol Biol Transl Sci (2011) 99, 1-50. PubMed  Europe PubMed DOI  V
  39. Xu,Z., Chen,Y.W., Battu,A., Wilder,P., Weber,D., Yu,W., Mackerell,A.D., Chen,L.M., Chai,K.X., Johnson,M.D. and Lin,C.Y.<br>Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade<br>J Med Chem (2011) 54, 7567-7578. PubMed  Europe PubMed DOI  I
    40. 2010
  40. Camerer,E., Barker,A., Duong,D.N., Ganesan,R., Kataoka,H., Cornelissen,I., Darragh,M.R., Hussain,A., Zheng,Y.W., Srinivasan,Y., Brown,C., Xu,S.M., Regard,J.B., Lin,C.Y., Craik,C.S., Kirchhofer,D. and Coughlin,S.R.<br>Local protease signaling contributes to neural tube closure in the mouse embryo<br>Dev Cell (2010) 18, 25-38. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Chen,Y.W., Wang,J.K., Chou,F.P., Chen,C.Y., Rorke,E.A., Chen,L.M., Chai,K.X., Eckert,R.L., Johnson,M.D. and Lin,C.Y.<br>Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation<br>J Biol Chem (2010) 285, 31755-31762. PubMed  Europe PubMed DOI
  42. Fu,Y.Y., Gao,W.L., Chen,M., Chai,K.X., Wang,Y.L. and Chen,L.M.<br>Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway<br>Hum Reprod (2010) 25, 623-632. PubMed  Europe PubMed DOI
  43. Ko,T., Kakizoe,Y., Wakida,N., Hayata,M., Uchimura,K., Shiraishi,N., Miyoshi,T., Adachi,M., Aritomi,S., Konda,T., Tomita,K. and Kitamura,K.<br>Regulation of adrenal aldosterone production by serine protease prostasin<br>J Biomed Biotechnol (2010) 2010, 793843-793843. PubMed  Europe PubMed DOI  PMC  EPMC  I
  44. Planes,C., Randrianarison,N.H., Charles,R.P., Frateschi,S., Cluzeaud,F., Vuagniaux,G., Soler,P., Clerici,C., Rossier,B.C. and Hummler,E.<br>ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1<br>EMBO Mol Med (2010) 2, 26-37. PubMed  Europe PubMed DOI  K
  45. Spacek,D.V., Perez,A.F., Ferranti,K.M., Wu,L.K., Moy,D.M., Magnan,D.R. and King,T.R.<br>The mouse frizzy (fr) and rat 'hairless' (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8)<br>Exp Dermatol (2010) 19, 527-532. PubMed  Europe PubMed DOI  M
    46. 2009
  46. Chen,L.M., Hatfield,M.L., Fu,Y.Y. and Chai,K.X.<br>Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells<br>Prostate (2009) 69, 1790-1801. PubMed  Europe PubMed DOI
  47. Ma,X.J., Fu,Y.Y., Li,Y.X., Chen,L.M., Chai,K. and Wang,Y.L.<br>Prostasin inhibits cell invasion in human choriocarcinomal JEG-3 cells<br>Histochem Cell Biol (2009) 132, 639-646. PubMed  Europe PubMed DOI
  48. Spraggon,G., Hornsby,M., Shipway,A., Tully,D.C., Bursulaya,B., Danahay,H., Harris,J.L. and Lesley,S.A.<br>Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations<br>Protein Sci (2009) 18, 1081-1094. PubMed  Europe PubMed DOI  PMC  EPMC  S
  49. Svenningsen,P., Uhrenholt,T.R., Palarasah,Y., Skjodt,K., Jensen,B.L. and Skott,O.<br>Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations<br>Am J Physiol Regul Integr Comp Physiol (2009) 297, R1733-R1741. PubMed  Europe PubMed DOI
    50. 2008
  50. Chen,M., Chen,L.M., Lin,C.Y. and Chai,K.X.<br>The epidermal growth factor receptor (EGFR) is proteolytically modified by the matriptase-prostasin serine protease cascade in cultured epithelial cells<br>Biochim Biophys Acta (2008) 1783, 896-903. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Rickert,K.W., Kelley,P., Byrne,N.J., Diehl,R.E., Hall,D.L., Montalvo,A.M., Reid,J.C., Shipman,J.M., Thomas,B.W., Munshi,S.K., Darke,P.L. and Su,H.P.<br>Structure of human prostasin, a target for the regulation of hypertension<br>J Biol Chem (2008) 283, 34864-34872. PubMed  Europe PubMed DOI  S
  52. Tully,D.C., Vidal,A., Chatterjee,A.K., Williams,J.A., Roberts,M.J., Petrassi,H.M., Spraggon,G., Bursulaya,B., Pacoma,R., Shipway,A., Schumacher,A.M., Danahay,H. and Harris,J.L.<br>Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design<br>Bioorg Med Chem Lett (2008) 18, 5895-5899. PubMed  Europe PubMed DOI  S  I
  53. Zhu,H., Guo,D., Li,K., Yan,W., Tan,Y., Wang,X., Treiber,F.A., Chao,J., Snieder,H. and Dong,Y.<br>Prostasin: a possible candidate gene for human hypertension<br>Am J Hypertens (2008) 21, 1028-1033. PubMed  Europe PubMed DOI
    54. 2007
  54. Bruns,J.B., Carattino,M.D., Sheng,S., Maarouf,A.B., Weisz,O.A., Pilewski,J.M., Hughey,R.P. and Kleyman,T.R.<br>Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit<br>J Biol Chem (2007) 282, 6153-6160. PubMed  Europe PubMed DOI
  55. Chen,M., Fu,Y.Y., Lin,C.Y., Chen,L.M. and Chai,K.X.<br>Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3<br>Biochim Biophys Acta (2007) 1773, 1133-1140. PubMed  Europe PubMed DOI  PMC  EPMC
  56. List,K., Hobson,J.P., Molinolo,A. and Bugge,T.H.<br>Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase<br>J Cell Physiol (2007) 213, 237-245. PubMed  Europe PubMed DOI
  57. Planes,C. and Caughey,G.H.<br>Regulation of the epithelial Na+ channel by peptidases<br>Curr Top Dev Biol (2007) 78, 23-46. PubMed  Europe PubMed DOI  PMC  EPMC
    58. 2006
  58. [YEAR:8-3-2006]Andreasen,D., Vuagniaux,G., Fowler-Jaeger,N., Hummler,E. and Rossier,B.C.<br>Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1<br>J Am Soc Nephrol (8-3-2006) 17, 968-976. PubMed  Europe PubMed DOI
  59. [YEAR:11-8-2006]Chen,M., Chen,L.M. and Chai,K.X.<br>Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression<br>Biochem Biophys Res Commun (11-8-2006) 346, 1245-1253. PubMed  Europe PubMed DOI
  60. Kleyman,T.R., Myerburg,M.M. and Hughey,R.P.<br>Regulation of ENaCs by proteases: an increasingly complex story<br>Kidney Int (2006) 70, 1391-1392. PubMed  Europe PubMed DOI
  61. [YEAR:26-6-2006]Lin,H.Y., Zhang,H., Yang,Q., Wang,H.X., Wang,H.M., Chai,K.X., Chen,L.M. and Zhu,C.<br>Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy<br>J Histochem Cytochem (26-6-2006) 54, 1139-1147. PubMed  Europe PubMed DOI
  62. [YEAR:15-9-2006]Netzel-Arnett,S., Currie,B.M., Szabo,R., Lin,C.Y., Chen,L.M., Chai,K.X., Antalis,T.M., Bugge,T.H. and List,K.<br>Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation<br>J Biol Chem (15-9-2006) 281, 32941-32945. PubMed  Europe PubMed DOI
  63. [YEAR:5-7-2006]Verghese,G.M., Gutknecht,M.F. and Caughey,G.H.<br>Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor<br>Am J Physiol Cell Physiol (5-7-2006) 291, C1258-C1270. PubMed  Europe PubMed DOI  PMC  EPMC
    64. 2005
  64. [YEAR:1-8-2005]Leyvraz,C., Charles,R.P., Rubera,I., Guitard,M., Rotman,S., Breiden,B., Sandhoff,K. and Hummler,E.<br>The epidermal barrier function is dependent on the serine protease CAP1/Prss8<br>J Cell Biol (1-8-2005) 170, 487-496. PubMed  Europe PubMed DOI  PMC  EPMC  K
  65. Olivieri,O., Castagna,A., Guarini,P., Chiecchi,L., Sabaini,G., Pizzolo,F., Corrocher,R. and Righetti,P.G.<br>Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans<br>Hypertension (2005) 46, 683-688. PubMed  Europe PubMed DOI
    66. 2004
  66. [YEAR:10-9-2004]Caldwell,R.A., Boucher,R.C. and Stutts,M.J.<br>Serine protease activation of near-silent epithelial Na+ channels<br>Am J Physiol Cell Physiol (10-9-2004) 286, C190-C194. PubMed  Europe PubMed DOI
  67. Chao,J.<br>Prostasin<br>[ISSN:0-12-079610-4] (2004) 2, 1708-1709.  V
  68. Chen,L.M., Zhang,X. and Chai,K.X.<br>Regulation of prostasin expression and function in the prostate<br>Prostate (2004) 59, 1-12. PubMed  Europe PubMed DOI
  69. [YEAR:12-11-2004]Shipway,A., Danahay,H., Williams,J.A., Tully,D.C., Backes,B.J. and Harris,J.L.<br>Biochemical characterization of prostasin, a channel activating protease<br>Biochem Biophys Res Commun (12-11-2004) 324, 953-963. PubMed  Europe PubMed DOI
  70. [YEAR:9-7-2004]Tong,Z., Illek,B., Bhagwandin,V.J., Verghese,G.M. and Caughey,G.H.<br>Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line<br>Am J Physiol Lung Cell Mol Physiol (9-7-2004) 287, L928-L935. PubMed  Europe PubMed DOI
  71. Verghese,G.M., Tong,Z.Y., Bhagwandin,V. and Caughey,G.H.<br>Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney<br>Am J Respir Cell Mol Biol (2004) 30, 519-529. PubMed  Europe PubMed DOI
    72. 2003
  72. Iwashita,K., Kitamura,K., Narikiyo,T., Adachi,M., Shiraishi,N., Miyoshi,T., Nagano,J., Tuyen,D.G., Nonoguchi,H. and Tomita,K.<br>Inhibition of prostasin secretion by serine protease inhibitors in the kidney<br>J Am Soc Nephrol (2003) 14, 11-16. PubMed  Europe PubMed DOI  I
  73. Wang,C., Chao,J. and Chao,L.<br>Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats<br>Am J Physiol Regul Integr Comp Physiol (2003) 284, R1031-R1036. PubMed  Europe PubMed DOI  U
    74. 2002
  74. [YEAR:20-1-2002]Chen,L.M. and Chai,K.X.<br>Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation<br>Int J Cancer (20-1-2002) 97, 323-329. PubMed  Europe PubMed DOI
  75. [YEAR:8-3-2002]Donaldson,S.H., Hirsh,A., Li,D.C., Holloway,G., Chao,J., Boucher,R.C. and Gabriel,S.E.<br>Regulation of the epithelial sodium channel by serine proteases in human airways<br>J Biol Chem (8-3-2002) 277, 8338-8345. PubMed  Europe PubMed DOI
  76. Rubera,I., Meier,E., Vuagniaux,G., Merillat,A.M., Beermann,F., Rossier,B.C. and Hummler,E.<br>A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus<br>Genesis (2002) 32, 173-176. PubMed  Europe PubMed DOI
  77. Vallet,V., Pfister,C., Loffing,J. and Rossier,B.C.<br>Cell-surface expression of the channel activating protease xCAP-1 is required for activation of ENaC in the Xenopus oocyte<br>J Am Soc Nephrol (2002) 13, 588-594. PubMed  Europe PubMed
  78. Vuagniaux,G., Vallet,V., Jaeger,N.F., Hummler,E. and Rossier,B.C.<br>Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes<br>J Gen Physiol (2002) 120, 191-201. PubMed  Europe PubMed DOI  PMC  EPMC
    79. 2001
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