Substrates for peptidase S01.159: prostasin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
arginyl bond			peptide-Arg+peptide	N	-	-	NPe	Arg	CPe	-	-	-	Chao, 2004
D-Phe-Phe-Arg-NHMec			D-Phe-Phe-Arg+NHMec	S	-	DPh	Phe	Arg	AMC	-	-	-	Chao, 2004
D-Pro-Phe-Arg-NHMec			D-Pro-Phe-Arg+NHMec	S	-	DPr	Phe	Arg	AMC	-	-	-	Chao, 2004
D-Val-Leu-Arg-NHMec			D-Val-Leu-Arg+NHMec	S	-	DVa	Leu	Arg	AMC	-	-	-	Chao, 2004
scnn1g sodium channel, nonvoltage-gated 1 gamma	Q9WU39	1-655	peptide-Lys186+Ile-peptide	P	Arg	Lys	Arg	Lys	Ile	Ser	Gly	Lys	Bruns et al., 2007	23009
Z-Gly-Pro-Arg-NHMec			Z-Gly-Pro-Arg+NHMec	S	Z	Gly	Pro	Arg	AMC	-	-	-	Chao, 2004