$VAR1 = undef;

Summary for peptidase S01.157: chymotrypsin C

Names
MEROPS Name	chymotrypsin C
Other names	caldecrin, CTRC g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.157
Holotype	chymotrypsin C (Bos taurus), Uniprot accession Q7M3E1 (peptidase unit: 30-268), MERNUM MER0002738
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00287
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.2
Enzymology	BRENDA database
Proteolytic events	CutDB database (2 cleavages)
Activity status	human: active (Szilagyi, 2004) mouse: active (by similarity to rat) (Tomomura et al., 1995)
Physiology	Ruminant digestive enzyme. Reported to be factor that depresses plasma calcium in acute pancreatitis.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Chymotrypsin-C
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/lqfy-/-/-/- (based on 46 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	2	1	0	2	2	2	2
Pro	0	0	4	0	0	1	2	1
Ala	4	4	2	0	1	1	3	1
Val	5	4	6	0	4	1	2	0
Leu	2	3	4	15	7	7	3	4
Ile	2	0	1	0	0	0	0	0
Met	0	1	2	3	2	1	1	0
Phe	2	2	2	9	3	4	2	1
Tyr	1	2	3	6	4	1	3	3
Trp	0	1	1	1	1	0	1	0
Ser	2	5	4	0	3	3	2	2
Thr	1	0	1	0	2	3	2	2
Cys	1	1	0	0	0	1	0	0
Asn	3	0	2	1	4	4	5	2
Gln	5	7	3	10	1	2	0	2
Asp	1	2	2	0	4	5	3	4
Glu	8	6	4	0	2	2	2	5
Lys	0	1	1	0	0	1	2	1
Arg	2	2	0	0	0	1	4	6
His	0	1	2	0	1	0	0	1