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Literature for peptidase S01.157: chymotrypsin C

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, P Specificity, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Tao,Y., Chu,C., Sun,D., Xiang,J., Wu,B., Li,C. and Cui,W.<br>MicroRNA-486-3p Targets Chymotrypsin C to Regulate Pancreatic Cancer Progression and Immunosuppressive Factor Expression<br>Iran J Allergy Asthma Immunol (2024) 23, 727-737. PubMed  Europe PubMed DOI
    2. 2021
  2. Tomomura,A., Bandow,K. and Tomomura,M.<br>Purification and Biological Function of Caldecrin<br>Medicines (Basel) (2021) 8 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2020
  3. Bandow,K., Hasegawa,H., Tomomura,M. and Tomomura,A.<br>Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2<br>Biochem Biophys Res Commun (2020) 523, 1027-1033. PubMed  Europe PubMed DOI
  4. Girodon,E., Rebours,V., Chen,J.M., Pagin,A., Levy,P., Ferec,C. and Bienvenu,T.<br>Clinical interpretation of SPINK1 and CTRC variants in pancreatitis<br>Pancreatology (2020) 20, 1354-1367. PubMed  Europe PubMed DOI  V
  5. Toldi,V., Szabo,A. and Sahin-Toth,M.<br>Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation<br>J Biol Chem (2020) 295, 3447-3455. PubMed  Europe PubMed DOI
    6. 2019
  6. Geisz,A., Jancso,Z., Nemeth,B.C., Hegyi,E. and Sahin-Toth,M.<br>Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice<br>JCI Insight (2019) 4, e129717-e129717. PubMed  Europe PubMed DOI  M
  7. Nemeth,B.C., Hegyi,P. and Takacs,T.<br>Evaluation of the pathogenic significance of the novel p.T58M chymotrypsin C variant in recurrent acute pancreatitis<br>Pancreas (2019) 48, e12-e12. PubMed  Europe PubMed DOI  M
    8. 2016
  8. Jancso,Z. and Sahin-Toth,M.<br>Tighter control by chymotrypsin C (CTRC) explains lack of association between human anionic trypsinogen and hereditary pancreatitis<br>J Biol Chem (2016) 291, 12897-12905. PubMed  Europe PubMed DOI
  9. Szabo,A., Pilsak,C., Bence,M., Witt,H. and Sahin-Toth,M.<br>Complex formation of human proelastases with procarboxypeptidases A1 and A2<br>J Biol Chem (2016) 291, 17706-17716. PubMed  Europe PubMed DOI
    10. 2015
  10. Binker,M.G., Richards,D., Gaisano,H.Y. and Cosen-Binker,L.I.<br>ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation<br>Biochem Biophys Res Commun (2015) 463, 329-335. PubMed  Europe PubMed DOI  M
  11. LaRusch,J., Lozano-Leon,A., Stello,K., Moore,A., Muddana,V., O'Connell,M., Diergaarde,B., Yadav,D. and Whitcomb,D.C.<br>The common chymotrypsinogen C (CTRC) variant G60G (C.180T) increases risk of chronic pancreatitis but not recurrent acute pancreatitis in a North American population<br>Clin Transl Gastroenterol (2015) 6, e68-e68. PubMed  Europe PubMed DOI  M
  12. Szabo,A., Ludwig,M., Hegyi,E., Szepeova,R., Witt,H. and Sahin-Toth,M.<br>Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis<br>J Biol Chem (2015) 290, 17282-17292. PubMed  Europe PubMed DOI
  13. Tomomura,M. and Tomomura,A.<br>Caldecrin: a pancreas-derived hypocalcemic factor, regulates osteoclast formation and function<br>World J Biol Chem (2015) 6, 358-365. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2014
  14. Masamune,A.<br>Genetics of pancreatitis: the 2014 update<br>Tohoku J Exp Med (2014) 232, 69-77. PubMed  Europe PubMed DOI  M
    15. 2013
  15. Batra,J., Szabo,A., Caulfield,T.R., Soares,A.S., Sahin-Toth,M. and Radisky,E.S.<br>Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation<br>J Biol Chem (2013) 288, 9848-9859. PubMed  Europe PubMed DOI  P  S
  16. Beer,S., Zhou,J., Szabo,A., Keiles,S., Chandak,G.R., Witt,H. and Sahin-Toth,M.<br>Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk<br>Gut (2013) 62, 1616-1624. PubMed  Europe PubMed DOI  M
  17. Nemeth,B.C., Wartmann,T., Halangk,W. and Sahin-Toth,M.<br>Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop<br>J Biol Chem (2013) 288, 24049-24062. PubMed  Europe PubMed DOI
    18. 2012
  18. Szabo,A. and Sahin-Toth,M.<br>Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C<br>J Biol Chem (2012) 287, 20701-20710. PubMed  Europe PubMed DOI  M
  19. Szabo,A. and Sahin-Toth,M.<br>Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen<br>FEBS J (2012) 279, 4283-4292. PubMed  Europe PubMed DOI
  20. Szilagyi,L.<br>Chymotrypsin C<br>[ISSN:978-0-12-407742-3] (2012) 3, 2634-2639. DOI
    21. 2011
  21. Bence,M. and Sahin-Toth,M.<br>Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity<br>FEBS J (2011) 278, 4338-4350. PubMed  Europe PubMed DOI
  22. Felderbauer,P., Karakas,E., Fendrich,V., Lebert,R., Bartsch,D.K. and Bulut,K.<br>Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for "protective" (PRSS2) and "destructive" (CTRC) genetic factors<br>Exp Clin Endocrinol Diabetes (2011) 119, 26-29. PubMed  Europe PubMed DOI
  23. Lacruz,R.S., Smith,C.E., Smith,S.M., Hu,P., Bringas,P., Jr., Sahin-Toth,M., Moradian-Oldak,J. and Paine,M.L.<br>Chymotrypsin C (caldecrin) is associated with enamel development<br>J Dent Res (2011) 90, 1228-1233. PubMed  Europe PubMed DOI
  24. Szabo,A., Heja,D., Szakacs,D., Zboray,K., Kekesi,K.A., Radisky,E.S., Sahin-Toth,M. and Pal,G.<br>High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues<br>J Biol Chem (2011) 286, 22535-22545. PubMed  Europe PubMed DOI  P  I
  25. Szmola,R., Bence,M., Carpentieri,A., Szabo,A., Costello,C.E., Samuelson,J. and Sahin-Toth,M.<br>Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2<br>J Biol Chem (2011) 286, 1819-1827. PubMed  Europe PubMed DOI
  26. Tomomura,M., Fujii,T., Sakagami,H. and Tomomura,A.<br>Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice<br>In Vivo (2011) 25, 157-163. PubMed  Europe PubMed  U
  27. Wang,H., Yuan,D., Xu,R. and Chi,C.W.<br>Purification, cDNA cloning, and recombinant expression of chymotrypsin C from porcine pancreas<br>Acta Biochim Biophys Sin (Shanghai) (2011) 43, 568-575. PubMed  Europe PubMed DOI  E
  28. Zhou,J. and Sahin-Toth,M.<br>Chymotrypsin C mutations in chronic pancreatitis<br>J Gastroenterol Hepatol (2011) 26, 1238-1246. PubMed  Europe PubMed DOI  M
    29. 2010
  29. Hasegawa,H., Kido,S., Tomomura,M., Fujimoto,K., Ohi,M., Kiyomura,M., Kanegae,H., Inaba,A., Sakagami,H. and Tomomura,A.<br>Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity<br>J Biol Chem (2010) 285, 25448-25457. PubMed  Europe PubMed DOI
  30. Szmola,R. and Sahin-Toth,M.<br>Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells<br>Gut (2010) 59, 365-372. PubMed  Europe PubMed DOI  M
    31. 2009
  31. Chang,M.C., Chang,Y.T., Wei,S.C., Liang,P.C., Jan,I.S., Su,Y.N., Kuo,C.H. and Wong,J.M.<br>Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan<br>Pancreatology (2009) 9, 287-292. PubMed  Europe PubMed DOI  M
    32. 2008
  32. Masson,E., Chen,J.M., Scotet,V., Le Marechal,C. and Ferec,C.<br>Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis<br>Hum Genet (2008) 123, 83-91. PubMed  Europe PubMed DOI  M
  33. Rosendahl,J., Witt,H., Szmola,R., Bhatia,E., Ozsvari,B., Landt,O., Schulz,H.U., Gress,T.M., Pfutzer,R., Lohr,M., Kovacs,P., Bluher,M., Stumvoll,M., Choudhuri,G., Hegyi,P., te Morsche,R.H., Drenth,J.P., Truninger,K., Macek,M., Jr., Puhl,G., Witt,U., Schmidt,H., Buning,C., Ockenga,J., Kage,A., Groneberg,D.A., Nickel,R., Berg,T., Wiedenmann,B., Bodeker,H., Keim,V., Mossner,J., Teich,N. and Sahin-Toth,M.<br>Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis<br>Nat Genet (2008) 40, 78-82. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2007
  34. Szmola,R. and Sahin-Toth,M.<br>Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y<br>Proc Natl Acad Sci U S A (2007) 104, 11227-11232. PubMed  Europe PubMed DOI  PMC  EPMC  P
    35. 2006
  35. [YEAR:27-2-2006]Nemoda,Z. and Sahin-Toth,M.<br>Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen<br>J Biol Chem (27-2-2006) 281, 11879-11886. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2004
  36. Szilagyi,L.<br>Chymotrypsin C<br>[ISSN:0-12-079610-4] (2004) 2, 1501-1504.  V
    37. 2001
  37. [YEAR:23-11-2001]Tomomura,A., Yamada,H., Fujimoto,K., Inaba,A. and Katoh,S.<br>Determination of amino acid sequence responsible for suppression of bone resorption by serum calcium-decreasing factor (caldecrin)<br>FEBS Lett (23-11-2001) 508, 454-458. PubMed  Europe PubMed DOI
    38. 1998
  38. Yoshino-Yasuda,I., Kobayashi,K., Akiyama,M., Itoh,H., Tomomura,A. and Saheki,T.<br>Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene<br>J Biochem (1998) 123, 546-554. PubMed  Europe PubMed
    39. 1997
  39. Gomis-Ruth,F.X., Gomez-Ortiz,M., Vendrell,J., Ventura,S., Bode,W., Huber,R. and Aviles,F.X.<br>Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation<br>J Mol Biol (1997) 269, 861-880. PubMed  Europe PubMed DOI  S
    40. 1996
  40. Gudmundsdottir,E., Spilliaert,R., Yang,Q., Craik,C.S., Bjarnason,J.B. and Gudmundsdottir,A.<br>Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases<br>Comp Biochem Physiol B Biochem Mol Biol (1996) 113, 795-801. PubMed  Europe PubMed DOI
  41. Tomomura,A., Akiyama,M., Itoh,H., Yoshino,I., Tomomura,M., Nishii,Y., Noikura,T. and Saheki,T.<br>Molecular cloning and expression of human caldecrin<br>FEBS Lett (1996) 386, 26-28. PubMed  Europe PubMed DOI
    42. 1995
  42. Gomis-Ruth,F.X., Gomez,M., Bode,W., Huber,R. and Aviles,F.X.<br>The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C<br>EMBO J (1995) 14, 4387-4394. PubMed  Europe PubMed  PMC  EPMC  S
  43. Tomomura,A., Tomomura,M., Fukushige,T., Akiyama,M., Kubota,N., Kumaki,K., Nishii,Y., Noikura,T. and Saheki,T.<br>Molecular cloning and expression of serum calcium-decreasing factor (caldecrin)<br>J Biol Chem (1995) 270, 30315-30321. PubMed  Europe PubMed DOI
    44. 1993
  44. Tomomura,A., Fukushige,T., Tomomura,M., Noikura,T., Nishii,Y. and Saheki,T.<br>Caldecrin proform requires trypsin activation for the acquisition of serum calcium-decreasing activity<br>FEBS Lett (1993) 335, 213-216. PubMed  Europe PubMed DOI
    45. 1992
  45. Tomomura,A., Fukushige,T., Noda,T., Noikura,T. and Saheki,T.<br>Serum calcium-decreasing factor (caldecrin) from porcine pancreas has proteolytic activity which has no clear connection with the calcium decrease<br>FEBS Lett (1992) 301, 277-281. PubMed  Europe PubMed DOI
    46. 1988
  46. Rinderknecht,H., Adham,N.F., Renner,I.G. and Carmack,C.<br>A possible zymogen self-destruct mechanism preventing pancreatic autodigestion<br>Int J Pancreatol (1988) 3, 33-44. PubMed  Europe PubMed DOI
    47. 1987
  47. Akama,K. and Tobita,T.<br>Simultaneous purification of carboxypeptidase A, carboxypeptidase B and chymotrypsin C from autolyzed porcine pancreas glands<br>Anal Sci (1987) 3, 167-170. DOI
    48. 1985
  48. [YEAR:4-10-1985]Iio-Akama,K., Sasamoto,H., Miyazawa,K., Miura,S. and Tobita,T.<br>Active forms of chymotrypsin C isolated from autolyzed porcine pancreas glands<br>Biochim Biophys Acta (4-10-1985) 831, 249-256. PubMed  Europe PubMed DOI
    49. 1970
  49. [YEAR:13-10-1970]Behnke,W.D., Wade,R.D. and Neurath,H.<br>Interactions of the endopeptidase subunit of bovine procarboxypeptidase A-S6<br>Biochemistry (13-10-1970) 9, 4179-4188. PubMed  Europe PubMed  I
  50. Folk,J.E.<br>Chymotrypsin C (porcine pancreas)<br>Methods Enzymol (1970) 19, 109-112. DOI  V
  51. Wilcox,P.E.<br>Chymotrypsinogens - chymotrypsins<br>Methods Enzymol (1970) 19, 64-108. DOI  V
    52. 1969
  52. Peanasky,R.J., Gratecos,D., Baratti,J. and Rovery,M.<br>Mode of activation and N-terminal sequence of subunit II in bovine procarboxypeptidase A and of porcine chymotrypsinogen C<br>Biochim Biophys Acta (1969) 181, 82-92. PubMed  Europe PubMed
    53. 1965
  53. Folk,J.E. and Cole,P.W.<br>Chymotrypsin C. II. Enzymatic specificity toward several polypeptides<br>J Biol Chem (1965) 240, 193-197. PubMed  Europe PubMed
  54. Folk,J.E. and Schirmer,E.W.<br>Chymotrypsin C. 1. Isolation of the zymogen and the active enzyme: preliminary structure and specificity studies<br>J Biol Chem (1965) 240, 181-192. PubMed  Europe PubMed

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