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Literature for peptidase S01.157: chymotrypsin C

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, P Specificity, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Tao,Y., Chu,C., Sun,D., Xiang,J., Wu,B., Li,C. and Cui,W.
    MicroRNA-486-3p Targets Chymotrypsin C to Regulate Pancreatic Cancer Progression and Immunosuppressive Factor Expression
    Iran J Allergy Asthma Immunol23, 727-737. PubMed  Europe PubMed DOI
    2. 2021
  2. Tomomura,A., Bandow,K. and Tomomura,M.
    Purification and Biological Function of Caldecrin
    Medicines (Basel)8, PubMed  Europe PubMed DOI
    3. 2020
  3. Bandow,K., Hasegawa,H., Tomomura,M. and Tomomura,A.
    Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2
    Biochem Biophys Res Commun523, 1027-1033. PubMed  Europe PubMed DOI
  4. Girodon,E., Rebours,V., Chen,J.M., Pagin,A., Levy,P., Ferec,C. and Bienvenu,T.
    Clinical interpretation of SPINK1 and CTRC variants in pancreatitis
    Pancreatology20, 1354-1367. PubMed  Europe PubMed DOI  V
  5. Toldi,V., Szabo,A. and Sahin-Toth,M.
    Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation
    J Biol Chem295, 3447-3455. PubMed  Europe PubMed DOI
    6. 2019
  6. Geisz,A., Jancso,Z., Nemeth,B.C., Hegyi,E. and Sahin-Toth,M.
    Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice
    JCI Insight4, e129717-e129717. PubMed  Europe PubMed DOI  M
  7. Nemeth,B.C., Hegyi,P. and Takacs,T.
    Evaluation of the pathogenic significance of the novel p.T58M chymotrypsin C variant in recurrent acute pancreatitis
    Pancreas48, e12-e12. PubMed  Europe PubMed DOI  M
    8. 2016
  8. Jancso,Z. and Sahin-Toth,M.
    Tighter control by chymotrypsin C (CTRC) explains lack of association between human anionic trypsinogen and hereditary pancreatitis
    J Biol Chem291, 12897-12905. PubMed  Europe PubMed DOI
  9. Szabo,A., Pilsak,C., Bence,M., Witt,H. and Sahin-Toth,M.
    Complex formation of human proelastases with procarboxypeptidases A1 and A2
    J Biol Chem291, 17706-17716. PubMed  Europe PubMed DOI
    10. 2015
  10. Binker,M.G., Richards,D., Gaisano,H.Y. and Cosen-Binker,L.I.
    ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation
    Biochem Biophys Res Commun463, 329-335. PubMed  Europe PubMed DOI  M
  11. LaRusch,J., Lozano-Leon,A., Stello,K., Moore,A., Muddana,V., O'Connell,M., Diergaarde,B., Yadav,D. and Whitcomb,D.C.
    The common chymotrypsinogen C (CTRC) variant G60G (C.180T) increases risk of chronic pancreatitis but not recurrent acute pancreatitis in a North American population
    Clin Transl Gastroenterol6, e68-e68. PubMed  Europe PubMed DOI  M
  12. Szabo,A., Ludwig,M., Hegyi,E., Szepeova,R., Witt,H. and Sahin-Toth,M.
    Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis
    J Biol Chem290, 17282-17292. PubMed  Europe PubMed DOI
  13. Tomomura,M. and Tomomura,A.
    Caldecrin: a pancreas-derived hypocalcemic factor, regulates osteoclast formation and function
    World J Biol Chem6, 358-365. PubMed  Europe PubMed DOI
    14. 2014
  14. Masamune,A.
    Genetics of pancreatitis: the 2014 update
    Tohoku J Exp Med232, 69-77. PubMed  Europe PubMed DOI  M
    15. 2013
  15. Batra,J., Szabo,A., Caulfield,T.R., Soares,A.S., Sahin-Toth,M. and Radisky,E.S.
    Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation
    J Biol Chem288, 9848-9859. PubMed  Europe PubMed DOI  P  S
  16. Beer,S., Zhou,J., Szabo,A., Keiles,S., Chandak,G.R., Witt,H. and Sahin-Toth,M.
    Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk
    Gut62, 1616-1624. PubMed  Europe PubMed DOI  M
  17. Nemeth,B.C., Wartmann,T., Halangk,W. and Sahin-Toth,M.
    Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop
    J Biol Chem288, 24049-24062. PubMed  Europe PubMed DOI
    18. 2012
  18. Szabo,A. and Sahin-Toth,M.
    Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen
    FEBS J279, 4283-4292. PubMed  Europe PubMed DOI
  19. Szabo,A. and Sahin-Toth,M.
    Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C
    J Biol Chem287, 20701-20710. PubMed  Europe PubMed DOI  M
  20. Szilagyi,L.
    Chymotrypsin C
    [ISSN:978-0-12-407742-3]3, 2634-2639. DOI
    21. 2011
  21. Bence,M. and Sahin-Toth,M.
    Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity
    FEBS J278, 4338-4350. PubMed  Europe PubMed DOI
  22. Felderbauer,P., Karakas,E., Fendrich,V., Lebert,R., Bartsch,D.K. and Bulut,K.
    Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for "protective" (PRSS2) and "destructive" (CTRC) genetic factors
    Exp Clin Endocrinol Diabetes119, 26-29. PubMed  Europe PubMed DOI
  23. Lacruz,R.S., Smith,C.E., Smith,S.M., Hu,P., Bringas,P., Jr., Sahin-Toth,M., Moradian-Oldak,J. and Paine,M.L.
    Chymotrypsin C (caldecrin) is associated with enamel development
    J Dent Res90, 1228-1233. PubMed  Europe PubMed DOI
  24. Szabo,A., Heja,D., Szakacs,D., Zboray,K., Kekesi,K.A., Radisky,E.S., Sahin-Toth,M. and Pal,G.
    High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues
    J Biol Chem286, 22535-22545. PubMed  Europe PubMed DOI  P  I
  25. Szmola,R., Bence,M., Carpentieri,A., Szabo,A., Costello,C.E., Samuelson,J. and Sahin-Toth,M.
    Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2
    J Biol Chem286, 1819-1827. PubMed  Europe PubMed DOI
  26. Tomomura,M., Fujii,T., Sakagami,H. and Tomomura,A.
    Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice
    In Vivo25, 157-163. PubMed  Europe PubMed  U
  27. Wang,H., Yuan,D., Xu,R. and Chi,C.W.
    Purification, cDNA cloning, and recombinant expression of chymotrypsin C from porcine pancreas
    Acta Biochim Biophys Sin (Shanghai)43, 568-575. PubMed  Europe PubMed DOI  E
  28. Zhou,J. and Sahin-Toth,M.
    Chymotrypsin C mutations in chronic pancreatitis
    J Gastroenterol Hepatol26, 1238-1246. PubMed  Europe PubMed DOI  M
    29. 2010
  29. Hasegawa,H., Kido,S., Tomomura,M., Fujimoto,K., Ohi,M., Kiyomura,M., Kanegae,H., Inaba,A., Sakagami,H. and Tomomura,A.
    Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity
    J Biol Chem285, 25448-25457. PubMed  Europe PubMed DOI
  30. Szmola,R. and Sahin-Toth,M.
    Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells
    Gut59, 365-372. PubMed  Europe PubMed DOI  M
    31. 2009
  31. Chang,M.C., Chang,Y.T., Wei,S.C., Liang,P.C., Jan,I.S., Su,Y.N., Kuo,C.H. and Wong,J.M.
    Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan
    Pancreatology9, 287-292. PubMed  Europe PubMed DOI  M
    32. 2008
  32. Masson,E., Chen,J.M., Scotet,V., Le Marechal,C. and Ferec,C.
    Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis
    Hum Genet123, 83-91. PubMed  Europe PubMed DOI  M
  33. Rosendahl,J., Witt,H., Szmola,R., Bhatia,E., Ozsvari,B., Landt,O., Schulz,H.U., Gress,T.M., Pfutzer,R., Lohr,M., Kovacs,P., Bluher,M., Stumvoll,M., Choudhuri,G., Hegyi,P., te Morsche,R.H., Drenth,J.P., Truninger,K., Macek,M., Jr., Puhl,G., Witt,U., Schmidt,H., Buning,C., Ockenga,J., Kage,A., Groneberg,D.A., Nickel,R., Berg,T., Wiedenmann,B., Bodeker,H., Keim,V., Mossner,J., Teich,N. and Sahin-Toth,M.
    Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
    Nat Genet40, 78-82. PubMed  Europe PubMed DOI
    34. 2007
  34. Szmola,R. and Sahin-Toth,M.
    Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y
    Proc Natl Acad Sci U S A104, 11227-11232. PubMed  Europe PubMed DOI  P
    35. 2006
  35. [YEAR:27-2-2006]Nemoda,Z. and Sahin-Toth,M.
    Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen
    J Biol Chem281, 11879-11886. PubMed  Europe PubMed DOI
    36. 2004
  36. Szilagyi,L.
    Chymotrypsin C
    [ISSN:0-12-079610-4]2, 1501-1504.  V
    37. 2001
  37. [YEAR:23-11-2001]Tomomura,A., Yamada,H., Fujimoto,K., Inaba,A. and Katoh,S.
    Determination of amino acid sequence responsible for suppression of bone resorption by serum calcium-decreasing factor (caldecrin)
    FEBS Lett508, 454-458. PubMed  Europe PubMed DOI
    38. 1998
  38. Yoshino-Yasuda,I., Kobayashi,K., Akiyama,M., Itoh,H., Tomomura,A. and Saheki,T.
    Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene
    J Biochem123, 546-554. PubMed  Europe PubMed
    39. 1997
  39. Gomis-Ruth,F.X., Gomez-Ortiz,M., Vendrell,J., Ventura,S., Bode,W., Huber,R. and Aviles,F.X.
    Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation
    J Mol Biol269, 861-880. PubMed  Europe PubMed DOI  S
    40. 1996
  40. Gudmundsdottir,E., Spilliaert,R., Yang,Q., Craik,C.S., Bjarnason,J.B. and Gudmundsdottir,A.
    Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases
    Comp Biochem Physiol B Biochem Mol Biol113, 795-801. PubMed  Europe PubMed DOI
  41. Tomomura,A., Akiyama,M., Itoh,H., Yoshino,I., Tomomura,M., Nishii,Y., Noikura,T. and Saheki,T.
    Molecular cloning and expression of human caldecrin
    FEBS Lett386, 26-28. PubMed  Europe PubMed DOI
    42. 1995
  42. Gomis-Ruth,F.X., Gomez,M., Bode,W., Huber,R. and Aviles,F.X.
    The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C
    EMBO J14, 4387-4394. PubMed  Europe PubMed  S
  43. Tomomura,A., Tomomura,M., Fukushige,T., Akiyama,M., Kubota,N., Kumaki,K., Nishii,Y., Noikura,T. and Saheki,T.
    Molecular cloning and expression of serum calcium-decreasing factor (caldecrin)
    J Biol Chem270, 30315-30321. PubMed  Europe PubMed DOI
    44. 1993
  44. Tomomura,A., Fukushige,T., Tomomura,M., Noikura,T., Nishii,Y. and Saheki,T.
    Caldecrin proform requires trypsin activation for the acquisition of serum calcium-decreasing activity
    FEBS Lett335, 213-216. PubMed  Europe PubMed DOI
    45. 1992
  45. Tomomura,A., Fukushige,T., Noda,T., Noikura,T. and Saheki,T.
    Serum calcium-decreasing factor (caldecrin) from porcine pancreas has proteolytic activity which has no clear connection with the calcium decrease
    FEBS Lett301, 277-281. PubMed  Europe PubMed DOI
    46. 1988
  46. Rinderknecht,H., Adham,N.F., Renner,I.G. and Carmack,C.
    A possible zymogen self-destruct mechanism preventing pancreatic autodigestion
    Int J Pancreatol3, 33-44. PubMed  Europe PubMed DOI
    47. 1987
  47. Akama,K. and Tobita,T.
    Simultaneous purification of carboxypeptidase A, carboxypeptidase B and chymotrypsin C from autolyzed porcine pancreas glands
    Anal Sci3, 167-170. DOI
    48. 1985
  48. [YEAR:4-10-1985]Iio-Akama,K., Sasamoto,H., Miyazawa,K., Miura,S. and Tobita,T.
    Active forms of chymotrypsin C isolated from autolyzed porcine pancreas glands
    Biochim Biophys Acta831, 249-256. PubMed  Europe PubMed DOI
    49. 1970
  49. [YEAR:13-10-1970]Behnke,W.D., Wade,R.D. and Neurath,H.
    Interactions of the endopeptidase subunit of bovine procarboxypeptidase A-S6
    Biochemistry9, 4179-4188. PubMed  Europe PubMed  I
  50. Folk,J.E.
    Chymotrypsin C (porcine pancreas)
    Methods Enzymol19, 109-112. DOI  V
  51. Wilcox,P.E.
    Chymotrypsinogens - chymotrypsins
    Methods Enzymol19, 64-108. DOI  V
    52. 1969
  52. Peanasky,R.J., Gratecos,D., Baratti,J. and Rovery,M.
    Mode of activation and N-terminal sequence of subunit II in bovine procarboxypeptidase A and of porcine chymotrypsinogen C
    Biochim Biophys Acta181, 82-92. PubMed  Europe PubMed
    53. 1965
  53. Folk,J.E. and Schirmer,E.W.
    Chymotrypsin C. 1. Isolation of the zymogen and the active enzyme: preliminary structure and specificity studies
    J Biol Chem240, 181-192. PubMed  Europe PubMed
  54. Folk,J.E. and Cole,P.W.
    Chymotrypsin C. II. Enzymatic specificity toward several polypeptides
    J Biol Chem240, 193-197. PubMed  Europe PubMed

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