$VAR1 = undef;

Summary for peptidase M24.007: Xaa-Pro dipeptidase (eukaryote-type)

Names
MEROPS Name	Xaa-Pro dipeptidase (eukaryote-type)
Other names	peptidase D, PEPD g.p. (Homo sapiens), prolidase I, proline dipeptidase, peptidase 4 (Mus musculus), X-Pro dipeptidase

Domain architecture

MEROPS Classification
Classification	Clan MG >> Subclan (none) >> Family M24 >> Subfamily B >> M24.007
Holotype	Xaa-Pro dipeptidase (eukaryote-type) (Homo sapiens), Uniprot accession P12955 (peptidase unit: 225-477), MERNUM MER0001248
History	Identifier created: MEROPS 3.03 (10 September 1998)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00241
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Mock, 2004) mouse: active (by similarity to rat) (Hu et al., 2003)
Knockout	Prolidase deficiency is an autosomal recessive disorder with highly variable penetrance characterized by massive urinary excretion of imidodipeptides X-Pro and X-Hyp (Ledoux et al., 1996; Mandel et al., 2000). Prolidase deficiency is a risk factor for the development of systemic lupus erythematosus (Shrinath et al., 1997).
Pharmaceutical relevance	Recombinant prolidase is capable of destroying the organophosphorus toxin, soman (Wang et al., 2005).
Other databases	TREEFAM	http://www.treefam.org/family/TF313396