Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M24.007: Xaa-Pro dipeptidase (eukaryote-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jaworowska,A. and Miltyk,W.
    Where does prolidase come from and where is it heading? - A review of recent findings
    Int J Biol Macromol (2025) 309, 143044-143044. PubMed  Europe PubMed DOI
    2. 2024
  2. Eni-Aganga,I., Lanaghan,Z.M., Ismail,F., Korolkova,O., Goodwin,J.S., Balasubramaniam,M., Dash,C. and Pandhare,J.
    KLF6 activates Sp1-mediated prolidase transcription during TGF-beta(1) signaling
    J Biol Chem (2024) 300, 105605-105605. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Fiorito,S., Genovese,S., Epifano,F. and Collevecchio,C.
    Prolidase activity assays. A survey of the reported literature methodologies
    Anal Biochem (2024) 689, 115506-115506. PubMed  Europe PubMed DOI  V
  4. Fiorito,S., Collevecchio,C., Epifano,F. and Genovese,S.
    Targeting prolidase. A survey of the literature data to depict a structure-activity relationship frame and to address future studies for drug development
    Bioorg Med Chem (2024) 110, 117833-117833. PubMed  Europe PubMed DOI  V
  5. Yildirim,B.B. and Kulaksizoglu,S.
    Prolidase could be considered a sign of inflammation associated with cigarette smoking
    Front Med (Lausanne) (2024) 11, 1347688-1347688. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Kabashima,T., Hamasaki,N., Tonooka,K. and Shibata,T.
    A Facile Method to Determine Prolidase Activity Using a Peptide-Specific Fluorometric Reaction
    Chem Pharm Bull (Tokyo) (2023) 71, 15-18. PubMed  Europe PubMed DOI
  7. Kayadibi,H., Koker,I.H., Gucin,Z., Senturk,H., Merzifonlu,S.C. and Ince,A.T.
    Comparison of the optimized direct spectrophotometric serum prolidase enzyme activity assay method with the currently used spectrophotometric assay methods and liver fibrosis indexes to distinguish the early stages of liver fibrosis in patients with chronic hepatitis B infection
    Lab Med (2023) 54, 652-658. PubMed  Europe PubMed DOI
  8. Pekkoc-Uyanik,K.C., Aslan,E.I., Kilicarslan,O., Ser,O.S., Ozyildirim,S., Yanar,F., Yildiz,A., Ozturk,O. and Yilmaz-Aydogan,H.
    Next-generation sequencing of prolidase gene identifies novel and common variants associated with low prolidase in coronary artery ectasia
    Mol Biol Rep (2023) 50, 1349-1365. PubMed  Europe PubMed DOI
  9. Szoka,L., Nazaruk,J., Giegiel,J. and Isidorov,V.
    Prolidase-proline oxidase axis is engaged in apoptosis induction by birch buds flavonol santin in endometrial adenocarcinoma cell line
    Front Mol Biosci (2023) 10, 1247536-1247536. PubMed  Europe PubMed DOI  PMC  EPMC  I
    10. 2022
  10. Czyrko-Horczak,J., Niziol,M., Forlino,A., Besio,R. and Miltyk,W.
    The Highly Efficient Expression System of Recombinant Human Prolidase and the Effect of N-Terminal His-Tag on the Enzyme Activity
    Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2021
  11. Eni-Aganga,I., Lanaghan,Z.M., Balasubramaniam,M., Dash,C. and Pandhare,J.
    PROLIDASE: A Review from Discovery to its Role in Health and Disease
    Front Mol Biosci (2021) 8, 723003-723003. PubMed  Europe PubMed DOI  PMC  EPMC  V
  12. Hajjar,N., Kabbani,M., Tannous,R., Lebre,A.S., Megarbane,A., Minari,A. and El Sayed,F.
    Prolidase Deficiency Causing Recalcitrant Leg Ulcerations in Siblings
    Adv Skin Wound Care (2021) 34, 1-4. PubMed  Europe PubMed DOI
  13. Palka,J., Oscilowska,I. and Szoka,L.
    Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy
    Amino Acids (2021) PubMed  Europe PubMed DOI  V
  14. Rossignol,F., Duarte Moreno,M.S., Benoist,J.F., Boehm,M., Bourrat,E., Cano,A., Chabrol,B., Cosson,C., Diaz,J.L.D., D'Harlingue,A., Dimmock,D., Freeman,A.F., Garcia,M.T., Garganta,C., Goerge,T., Halbach,S.S., de Laffolie,J., Lam,C.T., Martin,L., Martins,E., Meinhardt,A., Melki,I., Ombrello,A.K., Perez,N., Quelhas,D., Scott,A., Slavotinek,A.M., Soares,A.R., Stein,S.L., Sussmuth,K., Thies,J., Ferreira,C.R. and Schiff,M.
    Quantitative analysis of the natural history of prolidase deficiency: description of 17 families and systematic review of published cases
    Genet Med (2021) PubMed  Europe PubMed DOI  V
    15. 2020
  15. Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N.
    Human proline specific peptidases: a comprehensive analysis
    Biochim Biophys Acta Gen Subj (2020) 1864, 129636-129636. PubMed  Europe PubMed DOI  V
  16. Insolia,V., Priori,E.C., Gasperini,C., Coppa,F., Cocchia,M., Iervasi,E., Ferrari,B., Besio,R., Maruelli,S., Bernocchi,G., Forlino,A. and Bottone,M.G.
    Prolidase enzyme is required for extracellular matrix integrity and impacts on postnatal cerebellar cortex development
    J Comp Neurol (2020) 528, 61-80. PubMed  Europe PubMed DOI  K
  17. Misiura,M. and Miltyk,W.
    Current Understanding of the Emerging Role of Prolidase in Cellular Metabolism
    Int J Mol Sci (2020) 21, 5906-5906. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Misiura,M., Baszanowska,W., Oscilowska,I., Palka,J. and Miltyk,W.
    Prolidase Stimulates Proliferation and Migration through Activation of the PI3K/Akt/mTOR Signaling Pathway in Human Keratinocytes
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Razmi,T., Jindal,A.K., Arora,K., Joshi,V., Suri,D. and De,D.
    Refractory leg ulcers in prolidase deficiency with antiphospholipid antibody positivity responding to aspirin-hydroxychloroquine-vitamin C combination therapy
    Dermatol Ther (2020) , e14156-e14156. PubMed  Europe PubMed DOI
  20. Wator,E., Rutkiewicz,M., Weiss,M.S. and Wilk,P.
    Co-expression with chaperones can affect protein 3D structure as exemplified by loss-of-function variants of human prolidase
    FEBS Lett (2020) 594, 3045-3056. PubMed  Europe PubMed DOI
  21. Wilk,P., Wator,E. and Weiss,M.S.
    Prolidase - A protein with many faces
    Biochimie (2020) 183, 3-12. PubMed  Europe PubMed DOI  V
  22. Zareba,I., Huynh,T.Y.L., Kazberuk,A., Teul,J., Klupczynska,A., Matysiak,J., Surazynski,A. and Palka,J.
    Overexpression of Prolidase Induces Autophagic Death in MCF-7 Breast Cancer Cells
    Cell Physiol Biochem (2020) 54, 875-887. PubMed  Europe PubMed DOI
    23. 2019
  23. Kiratli Nalbant,E., Karaosmanoglu,N., Kutlu,O., Ceylaner,S. and Eksioglu,H.M.
    A rare case of prolidase deficiency with situs inversus totalis, identified by a novel mutation in the PEPD gene
    JAAD Case Rep (2019) 5, 436-438. PubMed  Europe PubMed DOI  PMC  EPMC  M
  24. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.
    A recombinant human protein targeting HER2 overcomes drug resistance in HER2-positive breast cancer
    Sci Transl Med (2019) 11, eaav1620-eaav1620. PubMed  Europe PubMed DOI
  25. Ysrayl,B.B., Balasubramaniam,M., Albert,I., Villalta,F., Pandhare,J. and Dash,C.
    A novel role of prolidase in cocaine-mediated breach in the barrier of brain microvascular endothelial cells
    Sci Rep (2019) 9, 2567-2567. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2018
  26. Bhatnager,R. and Dang,A.S.
    Comprehensive in-silico prediction of damage associated SNPs in human prolidase gene
    Sci Rep (2018) 8, 9430-9430. PubMed  Europe PubMed DOI  PMC  EPMC  M
  27. Wilk,P., Uehlein,M., Piwowarczyk,R., Dobbek,H., Mueller,U. and Weiss,M.S.
    Structural Basis for Prolidase Deficiency Disease Mechanisms
    FEBS J (2018) 285, 3422-3441. PubMed  Europe PubMed DOI  M  S
    28. 2017
  28. Tereshchenkova,V.F., Goptar,I.A., Zhuzhikov,D.P., Belozersky,M.A., Dunaevsky,Y.E., Oppert,B., Filippova,I.Y. and Elpidina,E.N.
    Prolidase is a critical enzyme for complete gliadin digestion in Tenebrio molitor larvae
    Arch Insect Biochem Physiol (2017) 95 PubMed  Europe PubMed DOI
  29. Wilk,P., Uehlein,M., Kalms,J., Dobbek,H., Mueller,U. and Weiss,M.S.
    Substrate specificity and reaction mechanism of human prolidase
    FEBS J (2017) 284, 2870-2885. PubMed  Europe PubMed DOI  S
  30. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.
    PEPD is a pivotal regulator of p53 tumor suppressor
    Nat Commun (2017) 8, 2052-2052. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Yun,H., Lee,S., Kim,S., Yu,J., Lee,N., Lee,J., Kim,N.D., Yu,C. and Rho,J.
    Improved hydrolysis of organophosphorus compounds by engineered human prolidases
    Protein Pept Lett (2017) 24, 617-625. PubMed  Europe PubMed DOI
    32. 2016
  32. Adisen,E., Erduran,F.B., Ezgu,F.S., Kasapkara,CS., Besio,R., Forlino,A. and Gurer,M.A.
    A rare cause of lower extremity ulcers: prolidase deficiency
    Int J Low Extrem Wounds (2016) 15, 86-91. PubMed  Europe PubMed DOI  M
  33. Hintze,J.P., Kirby,A., Torti,E. and Batanian,J.R.
    Prolidase deficiency in a Mexican-American patient identified by array CGH reveals a novel and the largest PEPD gene deletion
    Mol Syndr (2016) 7, 80-86. PubMed  Europe PubMed DOI  M
  34. Suri,D., Pandit,R.A., Saini,A.G., Dogra,S., Gupta,A., Rawat,A., Dwivedi,I., Masih,S. and Attri,S.V.
    A novel splice acceptor site mutation (IVS11 G > A) of PEPD gene causing prolidase deficiency associated with hyperimmunoglobulinemia E
    Gene Rep (2016) 4, 29-32. DOI  M
  35. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.
    Dual inhibition of ErbB1 and ErbB2 in cancer by recombinant human prolidase mutant hPEPD-G278D
    Oncotarget (2016) 7, 42340-42352. PubMed  Europe PubMed DOI
    36. 2015
  36. Besio,R., Maruelli,S., Gioia,R., Villa,I., Grabowski,P., Gallagher,O., Bishop,N.J., Foster,S., De Lorenzi,E., Colombo,R., Diaz,J.L., Moore-Barton,H., Deshpande,C., Aydin,H.I., Tokatli,A., Kwiek,B., Kasapkara,C.S., Adisen,E.O., Gurer,M.A., Di Rocco,M., Phang,J.M., Gunn,T.M., Tenni,R., Rossi,A. and Forlino,A.
    Lack of prolidase causes a bone phenotype both in human and in mouse
    Bone (2015) 72C, 53-64. PubMed  Europe PubMed DOI  M
  37. Lubick,K.J., Robertson,S.J., McNally,K.L., Freedman,B.A., Rasmussen,A.L., Taylor,R.T., Walts,A.D., Tsuruda,S., Sakai,M., Ishizuka,M., Boer,E.F., Foster,E.C., Chiramel,A.I., Addison,C.B., Green,R., Kastner,D.L., Katze,M.G., Holland,S.M., Forlino,A., Freeman,A.F., Boehm,M., Yoshii,K. and Best,S.M.
    Flavivirus antagonism of type I interferon signaling reveals prolidase as a regulator of IFNAR1 surface expression
    Cell Host Microbe (2015) 18, 61-74. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Rezk,P.E., Zdenka,P., Sabnekar,P., Kajih,T., Mata,D.G., Wrobel,C., Cerasoli,D.M. and Chilukuri,N.
    An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents
    Drug Chem Toxicol (2015) 38, 37-43. PubMed  Europe PubMed DOI
  39. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.
    Inhibition of ERBB2-overexpressing tumors by recombinant human prolidase and its enzymatically inactive mutant
    EBioMedicine (2015) 2, 396-405. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2014
  40. Insolia,V. and Piccolini,V.M.
    Brain morphological defects in prolidase deficient mice: first report
    Eur J Histochem (2014) 58, 2417-2417. PubMed  Europe PubMed DOI  M
  41. Lacarbonara,M., Cazzolla,A.P., Lacarbonara,V.A., DiVenere,D., Capogreco,M. and Marzo,G.
    Prolidase deficiency: dento-facial aspects in a paediatric patient
    Eur J Paediatr Dent (2014) 15, 224-228. PubMed  Europe PubMed  M
  42. Lin,Q.-Z., Yin,R.-X., Wu,J., Guo,T., Wang,W., Sun,J.-Q., Shi,G.-Y., Shen,S.-W., Wu,J.-Z. and Pan,S.-L.
    Sex-specific association of the peptidase D gene rs731839 polymorphism and serum lipid levels in the Mulao and Han populations
    Int J Clin Exp Pathol (2014) 7, 4156-4172. PubMed  Europe PubMed  M
  43. Pohl,M.O., Edinger,T.O. and Stertz,S.
    Prolidase is required for early trafficking events during influenza A virus entry
    J Virol (2014) 88, 11271-11283. PubMed  Europe PubMed DOI
    44. 2013
  44. Aleti,V., Reddy,G.B., Parikh,K., Arun,P. and Chilukuri,N.
    Persistent and high-level expression of human liver prolidase in vivo in mice using adenovirus
    Chem Biol Interact (2013) 203, 191-195. PubMed  Europe PubMed DOI  U
  45. Besio,R., Gioia,R., Cossu,F., Monzani,E., Nicolis,S., Cucca,L., Profumo,A., Casella,L., Tenni,R., Bolognesi,M., Rossi,A. and Forlino,A.
    Kinetic and structural evidences on human prolidase pathological mutants suggest strategies for enzyme functional rescue
    PLoS ONE (2013) 8, e58792-e58792. PubMed  Europe PubMed DOI  PMC  EPMC  M
  46. Besio,R., Baratto,M.C., Gioia,R., Monzani,E., Nicolis,S., Cucca,L., Profumo,A., Casella,L., Basosi,R., Tenni,R., Rossi,A. and Forlino,A.
    A Mn(II)-Mn(II) center in human prolidase
    Biochim Biophys Acta (2013) 1834, 197-204. PubMed  Europe PubMed DOI
  47. Chandrasekaran,L., Belinskaya,T. and Saxena,A.
    In vitro characterization of organophosphorus compound hydrolysis by native and recombinant human prolidase
    Toxicol In Vitro (2013) 27, 499-506. PubMed  Europe PubMed DOI  U
  48. Pandit,R.A., Chen,C.J., Butt,T.A. and Islam,N.
    Identification and analysis of a novel mutation in PEPD gene in two Kashmiri siblings with prolidase enzyme deficiency
    Gene (2013) 516, 316-319. PubMed  Europe PubMed DOI  M
  49. Yang,L., Li,Y., Ding,Y., Choi,K.S., Kazim,A.L. and Zhang,Y.
    Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling
    J Biol Chem (2013) 288, 2365-2375. PubMed  Europe PubMed DOI
    50. 2012
  50. Kitchener,R.L. and Grunden,A.M.
    Prolidase function in proline metabolism and its medical and biotechnological applications
    J Appl Microbiol (2012) 113, 233-247. PubMed  Europe PubMed DOI  V
  51. Kodama,H.
    Xaa-Pro dipeptidase (eukaryotes)
    [ISSN:978-0-12-407743-0] (2012) 3, 1507-1514. DOI
    52. 2011
  52. Alberto,M.E., Leopoldini,M. and Russo,N.
    Can human prolidase enzyme use different metals for full catalytic activity?
    Inorg Chem (2011) 50, 3394-3403. PubMed  Europe PubMed DOI
  53. Besio,R., Monzani,E., Gioia,R., Nicolis,S., Rossi,A., Casella,L. and Forlino,A.
    Improved prolidase activity assay allowed enzyme kinetic characterization and faster prolidase deficiency diagnosis
    Clin Chim Acta (2011) 412, 1814-1820. PubMed  Europe PubMed DOI  A
  54. Jung,S., Silvius,D., Nolan,K.A., Borchert,G.L., Millet,Y.H., Phang,J.M. and Gunn,T.M.
    Developmental cardiac hypertrophy in a mouse model of prolidase deficiency
    Birth Defects Res A Clin Mol Teratol (2011) 91, 204-217. PubMed  Europe PubMed DOI  M
    55. 2010
  55. Besio,R., Alleva,S., Forlino,A., Lupi,A., Meneghini,C., Minicozzi,V., Profumo,A., Stellato,F., Tenni,R. and Morante,S.
    Identifying the structure of the active sites of human recombinant prolidase
    Eur Biophys J (2010) 39, 935-945. PubMed  Europe PubMed DOI
  56. Falik-Zaccai,T.C., Khayat,M., Luder,A., Frenkel,P., Magen,D., Brik,R., Gershoni-Baruch,R. and Mandel,H.
    A broad spectrum of developmental delay in a large cohort of prolidase deficiency patients demonstrates marked interfamilial and intrafamilial phenotypic variability
    Am J Med Genet B Neuropsychiatr Genet (2010) 153B, 46-56. PubMed  Europe PubMed DOI  M
  57. Klar,A., Navon-Elkan,P., Rubinow,A., Branski,D., Hurvitz,H., Christensen,E., Khayat,M. and Falik-Zaccai,T.C.
    Prolidase deficiency: it looks like systemic lupus erythematosus but it is not
    Eur J Pediatr (2010) 169, 727-732. PubMed  Europe PubMed DOI  M
    58. 2009
  58. Uramatsu,S., Liu,G., Yang,Q., Uramatsu,M., Chi,H., Lu,J., Yamashita,K. and Kodama,H.
    Characterization of prolidase I and II purified from normal human erythrocytes: comparison with prolidase in erythrocytes from a patient with prolidase deficiency
    Amino Acids (2009) 37, 543-551. PubMed  Europe PubMed DOI
    59. 2008
  59. Colonna,C., Conti,B., Perugini,P., Pavanetto,F., Modena,T., Dorati,R., Iadarola,P. and Genta,I.
    Site-directed PEGylation as successful approach to improve the enzyme replacement in the case of prolidase
    Int J Pharm (2008) 358, 230-237. PubMed  Europe PubMed DOI  U
  60. Lupi,A., Tenni,R., Rossi,A., Cetta,G. and Forlino,A.
    Human prolidase and prolidase deficiency: an overview on the characterization of the enzyme involved in proline recycling and on the effects of its mutations
    Amino Acids (2008) 35, 739-752. PubMed  Europe PubMed DOI  V
  61. Surazynski,A., Donald,S.P., Cooper,S.K., Whiteside,M.A., Salnikow,K., Liu,Y. and Phang,J.M.
    Extracellular matrix and HIF-1 signaling: the role of prolidase
    Int J Cancer (2008) 122, 1435-1440. PubMed  Europe PubMed DOI
  62. Zhou,L., Yuan,J., Yin,J. and Wang,E.
    Kinetic study of prolidase activity in erythrocytes against different substrates using capillary electrophoresis with electrochemiluminescence detection
    J Chromatogr A (2008) 1200, 255-259. PubMed  Europe PubMed DOI  A
    63. 2007
  63. Liu,G., Nakayama,K., Awata,S., Tang,S., Kitaoka,N., Manabe,M. and Kodama,H.
    Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors
    Pediatr Res (2007) 62, 54-59. PubMed  Europe PubMed DOI
  64. Luder,A.S., Mandel,H., Khayat,M., Gurevich,I., Frankel,P., Rivlin,J. and Falik-Zaccai,T.C.
    Chronic lung disease and cystic fibrosis phenotype in prolidase deficiency: a newly recognized association
    J Pediatr (2007) 150, 656-658. PubMed  Europe PubMed DOI  M
  65. Mittal,S., Song,X., Vig,B.S. and Amidon,G.L.
    Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma
    Pharm Res (2007) 24, 1290-1298. PubMed  Europe PubMed DOI
  66. [YEAR:29-6-2007]Uramatsu,M., Liu,G., Uramatsu,S., Zhang,M., Wang,W., Nakayama,K., Manabe,M. and Kodama,H.
    Different effects of sulfur amino acids on prolidase and prolinase activity in normal and prolidase-deficient human erythrocytes
    Clin Chim Acta (29-6-2007) 375, 129-135. PubMed  Europe PubMed DOI
    67. 2006
  67. Hershkovitz,T., Hassoun,G., Indelman,M., Shlush,L.I., Bergman,R., Pollack,S. and Sprecher,E.
    A homozygous missense mutation in PEPD encoding peptidase D causes prolidase deficiency associated with hyper-IgE syndrome
    Clin Exp Dermatol (2006) 31, 435-440. PubMed  Europe PubMed DOI  M
  68. Kavala,M., Zindanci,I., Sudogan,S., Turkoglu,Z. and Sarigul,S.
    Ulcus cruris associated with prolidase deficiency
    Dermatol Online J (2006) 12, 24-24. PubMed  Europe PubMed  M
  69. [YEAR:27-10-2006]Kurien,B.T., Patel,N.C., Porter,A.C., D'Souza,A., Miller,D., Matsumoto,H., Wang,H. and Scofield,R.H.
    Prolidase deficiency and the biochemical assays used in its diagnosis
    Anal Biochem (27-10-2006) 349, 165-175. PubMed  Europe PubMed DOI  A  V
  70. [YEAR:1-11-2006]Lupi,A., Della Torre,S., Campari,E., Tenni,R., Cetta,G., Rossi,A. and Forlino,A.
    Human recombinant prolidase from eukaryotic and prokaryotic sources. Expression, purification, characterization and long-term stability studies
    FEBS J (1-11-2006) 273, 5466-5478. PubMed  Europe PubMed DOI  E
  71. Lupi,A., Rossi,A., Campari,E., Pecora,F., Lund,A.M., Elcioglu,N.H., Gultepe,M., Di Rocco,M., Cetta,G. and Forlino,A.
    Molecular characterisation of six patients with prolidase deficiency: identification of the first small duplication in the prolidase gene and of a mutation generating symptomatic and asymptomatic outcomes within the same family
    J Med Genet (2006) 43, e58-e58. PubMed  Europe PubMed DOI  M
  72. [YEAR:15-3-2006]Wang,H., Kurien,B.T., Lundgren,D., Patel,N.C., Kaufman,K.M., Miller,D.L., Porter,A.C., D'Souza,A., Nye,L., Tumbush,J., Hupertz,V., Kerr,D.S., Kurono,S., Matsumoto,H. and Scofield,R.H.
    A nonsense mutation of PEPD in four Amish children with prolidase deficiency
    Am J Med Genet A (15-3-2006) 140, 580-585. PubMed  Europe PubMed DOI  M
  73. [YEAR:22-8-2006]Wang,S.H., Zhi,Q.W. and Sun,M.J.
    Dual activities of human prolidase
    Toxicol In Vitro (22-8-2006) 20, 71-77. PubMed  Europe PubMed DOI  E
    74. 2005
  74. Liu,G., Nakayama,K., Sagara,Y., Awata,S., Yamashita,K., Manabe,M. and Kodama,H.
    Characterization of prolidase activity in erythrocytes from a patient with prolidase deficiency: Comparison with prolidase I and II purified from normal human erythrocytes
    Clin Biochem (2005) 38, 625-631. PubMed  Europe PubMed DOI
  75. [YEAR:30-6-2005]Lupi,A., Rossi,A., Vaghi,P., Gallanti,A., Cetta,G. and Forlino,A.
    N-Benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase
    Biochim Biophys Acta Mol Cell Res (30-6-2005) 1744, 157-163. PubMed  Europe PubMed DOI  I
  76. Mittal,S., Song,X., Vig,B.S., Landowski,C.P., Kim,I., Hilfinger,J.M. and Amidon,G.L.
    Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs
    Mol Pharm (2005) 2, 37-46. PubMed  Europe PubMed DOI
  77. [YEAR:20-1-2005]Perugini,P., Hassan,K., Genta,I., Modena,T., Pavanetto,F., Cetta,G., Zanone,C., Iadarola,P., Asti,A. and Conti,B.
    Intracellular delivery of liposome-encapsulated prolidase in cultured fibroblasts from prolidase-deficient patients
    J Control Release (20-1-2005) 102, 181-190. PubMed  Europe PubMed DOI
  78. [YEAR:15-9-2005]Surazynski,A., Liu,Y., Miltyk,W. and Phang,J.M.
    Nitric oxide regulates prolidase activity by serine/threonine phosphorylation
    J Cell Biochem (15-9-2005) 96, 1086-1094. PubMed  Europe PubMed DOI
  79. Wang,S.H., Zhi,Q.W. and Sun,M.J.
    Purification and characterization of recombinant human liver prolidase expressed in Saccharomyces cerevisiae
    Arch Toxicol (2005) 79, 253-259. PubMed  Europe PubMed DOI  E
    80. 2004
  80. Liu,G., Nakayama,K., Awata,S., Wang,W., Yamashita,K., Manabe,M. and Kodama,H.
    Effects of amino acids and its metabolites on prolidase activity against various iminodipeptides in erythrocytes from normal human and a patient with prolidase deficiency
    Clin Chim Acta (2004) 350, 211-217. PubMed  Europe PubMed DOI
  81. [YEAR:11-8-2004]Lupi,A., De Riso,A., Torre,S.D., Rossi,A., Campari,E., Vilarinho,L., Cetta,G. and Forlino,A.
    Characterization of a new PEPD allele causing prolidase deficiency in two unrelated patients: natural-occurrent mutations as a tool to investigate structure-function relationship
    J Hum Genet (11-8-2004) 49, 500-506. PubMed  Europe PubMed DOI
  82. Mock,W.L.
    X-Pro dipeptidase (eukaryote)
    [ISSN:0-12-079610-4] (2004) 2, 923-925.  V
  83. Wang,S.H., Liu,M., Chi,M.G., Wang,Q.D. and Sun,M.J.
    Production of human liver prolidase by Saccharomyces cerevisiae as host cells
    Acta Pharmacol Sin (2004) 25, 794-800. PubMed  Europe PubMed  E
    84. 2003
  84. Chrzanowski,K., Bielawska,A. and Palka,J.
    Proline analogue of melphalan as a prodrug susceptible to the action of prolidase in breast cancer MDA-MB 231 cells
    Farmaco (2003) 58, 1113-1119. PubMed  Europe PubMed DOI
  85. Hu,M., Cheng,Z. and Zheng,L.
    Functional and molecular characterization of rat intestinal prolidase
    Pediatr Res (2003) 53, 905-914. PubMed  Europe PubMed DOI
  86. Nakayama,K., Awata,S., Zhang,J., Kaba,H., Manabe,M. and Kodama,H.
    Characteristics of prolidase from the erythrocytes of normal humans and patients with prolidase deficiency and their mother
    Clin Chem Lab Med (2003) 41, 1323-1328. PubMed  Europe PubMed DOI
    87. 2002
  87. Forlino,A., Lupi,A., Vaghi,P., Icaro Cornaglia,A., Calligaro,A., Campari,E. and Cetta,G.
    Mutation analysis of five new patients affected by prolidase deficiency: the lack of enzyme activity causes necrosis-like cell death in cultured fibroblasts
    Hum Genet (2002) 111, 314-322. PubMed  Europe PubMed DOI
  88. Jalving,R., Bron,P., Kester,H.C., Visser,J. and Schaap,P.J.
    Cloning of a prolidase gene from Aspergillus nidulans and characterisation of its product
    Mol Genet Genomics (2002) 267, 218-222. PubMed  Europe PubMed DOI
    89. 2001
  89. Galicka,A., Wolczynski,S., Anchim,T., Surazynski,A., Lesniewicz,R. and Palka,J.
    Defects of type I procollagen metabolism correlated with decrease of prolidase activity in a case of lethal osteogenesis imperfecta
    Eur J Biochem (2001) 268, 2172-2178. PubMed  Europe PubMed DOI
  90. Surazynski,A., Palka,J. and Wolczynski,S.
    Phosphorylation of prolidase increases the enzyme activity
    Mol Cell Biochem (2001) 220, 95-101. PubMed  Europe PubMed DOI
    91. 2000
  91. Bielawska,A., Bielawski,K., Chrzanowski,K. and Wolczynski,S.
    Prolidase-activated prodrug for cancer chemotherapy cytotoxic activity of proline analogue of chlorambucil in breast cancer MCF-7 cells
    Farmaco (2000) 55, 736-741. PubMed  Europe PubMed DOI  I
  92. Mandel,H., Abeling,N., Gutman,A., Berant,M., Scholten,E.G., Sheiman,C., Luder,A. and van Gennip,A.H.
    Prolidase deficiency among an Israeli population: prenatal diagnosis in a genetic disorder with uncertain prognosis
    Prenat Diagn (2000) 20, 927-929. PubMed  Europe PubMed DOI  K
    93. 1997
  93. Shrinath,M., Walter,J.H., Haeney,M., Couriel,J.M., Lewis,M.A. and Herrick,A.L.
    Prolidase deficiency and systemic lupus erythematosus
    Arch Dis Child (1997) 76, 441-444. PubMed  Europe PubMed  PMC  EPMC  K
    94. 1996
  94. Ishii,T., Tsujino,S., Matsunobu,S., Endo,F., Sato,K. and Sakuragawa,N.
    Cloning of mouse prolidase cDNA: predominant expression of prolidase mRNA in kidney
    Biochim Biophys Acta (1996) 1308, 15-16. PubMed  Europe PubMed DOI
  95. Ledoux,P., Scriver,C.R. and Hechtman,P.
    Expression and molecular analysis of mutations in prolidase deficiency
    Am J Hum Genet (1996) 59, 1035-1039. PubMed  Europe PubMed  PMC  EPMC  K
    96. 1995
  96. Mock,W.L. and Liu,Y.
    Hydrolysis of picolinylprolines by prolidase. A general mechanism for the dual-metal ion containing aminopeptidases
    J Biol Chem (1995) 270, 18437-18446. PubMed  Europe PubMed DOI
  97. Mock,W.L. and Liu,Y.
    Inhibition of prolidase by phosphoenolpyruvate is biphasic. Avoidance of endogenous-metabolite inactivation by cooperativity within an enzyme dimer
    Bioorg Med Chem Lett (1995) 5, 627-630. DOI  I
    98. 1994
  98. Myara,I., Cosson,C., Moatti,N. and Lemonnier,A.
    Human kidney prolidase - purification, preincubation properties and immunological reactivity
    Int J Biochem (1994) 26, 207-214. PubMed  Europe PubMed DOI
  99. Zanaboni,G., Dyne,K.M., Rossi,A., Monafo,V. and Cetta,G.
    Prolidase deficiency: biochemical study of erythrocyte and skin fibroblast prolidase activity in Italian patients
    Haematologica (1994) 79, 13-18. PubMed  Europe PubMed
    100. 1993
  100. Rossignol,F., Wang,H. and Ferreira,C.
    Prolidase Deficiency
     (1993) PubMed  Europe PubMed
    101. 1992
  101. Cosson,C., Myara,I., Miech,G., Moatti,N. and Lemonnier,A.
    Only prolidase I activity is present in human plasma
    Int J Biochem (1992) 24, 427-432. PubMed  Europe PubMed DOI
  102. Hiraizumi,K., Hourani,C.L., Zambarano,M.C., Freeman,J.E. and Mathes,K.D.
    Dipeptidase-C in Drosophila melanogaster: Genetic, ontogenetic, and tissue-specific variation
    Biochem Genet (1992) 30, 603-624. PubMed  Europe PubMed
    103. 1991
  103. [YEAR:15-10-1991]Mock,W.L. and Zhuang,H.
    Chemical modification locates guanidinyl and carboxylate groups within the active site of prolidase
    Biochem Biophys Res Commun (15-10-1991) 180, 401-406. PubMed  Europe PubMed DOI
  104. Tanoue,A., Endo,F., Akaboshi,I., Oono,T., Arata,J. and Matsuda,I.
    Molecular defect in siblings with prolidase deficiency and absence or presence of clinical symptoms. A 0.8-kb deletion with breakpoints at the short, direct repeat in the PEPD gene and synthesis of abnormal messenger RNA and inactive polypeptide
    J Clin Invest (1991) 87, 1171-1176. PubMed  Europe PubMed DOI  PMC  EPMC  M
    105. 1990
  105. [YEAR:15-11-1990]Mock,W.L., Green,P.C. and Boyer,K.D.
    Specificity and pH dependence for acylproline cleavage by prolidase
    J Biol Chem (15-11-1990) 265, 19600-19605. PubMed  Europe PubMed
  106. [YEAR:15-11-1990]Mock,W.L. and Green,P.C.
    Mechanism and inhibition of prolidase
    J Biol Chem (15-11-1990) 265, 19606-19610. PubMed  Europe PubMed
  107. [YEAR:31-1-1990]Ohhashi,T., Ohno,T., Arata,J., Sugahara,K. and Kodama,H.
    Characterization of prolidase I and II from erythrocytes of a control, a patient with prolidase deficiency and her mother
    Clin Chim Acta (31-1-1990) 187, 1-9. PubMed  Europe PubMed DOI
  108. Oono,T., Yasutomi,H., Ohhashi,T., Kodama,H. and Arata,J.
    Characterization of fibroblast-derived prolidase. The presence of two forms of prolidase
    J Dermatol Sci (1990) 1, 319-323. PubMed  Europe PubMed DOI
  109. [YEAR:5-7-1990]Tanoue,A., Endo,F. and Matsuda,I.
    Structural organization of the gene for human prolidase (peptidase D) and demonstration of a partial gene deletion in a patient with prolidase deficiency
    J Biol Chem (5-7-1990) 265, 11306-11311. PubMed  Europe PubMed
    110. 1989
  110. Endo,F., Tanoue,A., Nakai,H., Hata,A., Indo,Y., Titani,K. and Matsuda,I.
    Primary structure and gene localization of human prolidase
    J Biol Chem (1989) 264, 4476-4481. PubMed  Europe PubMed
  111. Kodama,H., Ohhashi,T., Ohba,C., Ohno,T., Arata,J., Kubonishi,I. and Miyoshi,I.
    Characteristics and partial purification of prolidase and prolinase from leukocytes of a normal human and a patient with prolidase deficiency
    Clin Chim Acta (1989) 180, 65-72. PubMed  Europe PubMed
  112. Richter,A.M., Lancaster,G.L., Choy,F.Y. and Hechtman,P.
    Purification and characterization of activated human erythrocyte prolidase
    Biochem Cell Biol (1989) 67, 34-41. PubMed  Europe PubMed
    113. 1988
  113. Hechtman,P., Richter,A., Corman,N. and Leong,Y.M.
    In situ activation of human erythrocyte prolidase: potential for enzyme replacement therapy in prolidase deficiency
    Pediatr Res (1988) 24, 709-712. PubMed  Europe PubMed DOI  U
    114. 1987
  114. Myara,I.
    Effect of long preincubation on the two forms of human erythrocyte prolidase
    Clin Chim Acta (1987) 170, 263-270. PubMed  Europe PubMed
    115. 1986
  115. [YEAR:11-3-1986]King,G.F., Middlehurst,C.R. and Kuchel,P.W.
    Direct NMR evidence that prolidase is specific for the trans isomer of imidodipeptide substrates
    Biochemistry (11-3-1986) 25, 1054-1062. PubMed  Europe PubMed
    116. 1985
  116. Ganapathy,V., Pashley,S.J., Roesel,R.A., Pashley,D.H. and Leibach,F.H.
    Inhibition of rat and human prolidases by captopril
    Biochem Pharmacol (1985) 34, 1287-1291. PubMed  Europe PubMed DOI  I
    117. 1984
  117. Butterworth,J. and Priestman,D.
    Substrate specificity of manganese-activated prolidase in control and prolidase-deficient cultured skin fibroblasts
    J Inherit Metab Dis (1984) 7, 32-34. PubMed  Europe PubMed
  118. [YEAR:21-5-1984]Myara,I., Charpentier,C. and Lemonnier,A.
    Prolidase and prolidase deficiency
    Life Sci (21-5-1984) 34, 1985-1998. PubMed  Europe PubMed DOI
  119. [YEAR:29-9-1984]Priestman,D.A. and Butterworth,J.
    Prolidase deficiency: characteristics of human skin fibroblast prolidase using colorimetric and fluorimetric assays
    Clin Chim Acta (29-9-1984) 142, 263-271. PubMed  Europe PubMed DOI
    120. 1983
  120. Browne,P. and O'Cuinn,G.
    The purification and characterization of a proline dipeptidase from guinea pig brain
    J Biol Chem (1983) 258, 6147-6154. PubMed  Europe PubMed
  121. Yoshimoto,T., Matsubara,F., Kawano,E. and Tsuru,D.
    Prolidase from bovine intestine: purification and characterization
    J Biochem (1983) 94, 1889-1896. PubMed  Europe PubMed
    122. 1982
  122. Der Kaloustian,V.M., Freij,B.J. and Kurban,A.K.
    Prolidase deficiency: an inborn error of metabolism with major dermatological manifestations
    Dermatologica (1982) 164, 293-304. PubMed  Europe PubMed
  123. Endo,F., Matsuda,I., Ogata,A. and Tanaka,S.
    Human erythrocyte prolidase and prolidase deficiency
    Pediatr Res (1982) 16, 227-231. PubMed  Europe PubMed
  124. [YEAR:27-10-1982]Myara,I., Charpentier,C. and Lemonnier,A.
    Optimal conditions for prolidase assay by proline colorimetric determination: application to iminodipeptiduria
    Clin Chim Acta (27-10-1982) 125, 193-205. PubMed  Europe PubMed DOI  A
    125. 1981
  125. Isemura,M., Hanyu,T., Ono,T., Igarashi,R., Sato,Y., Gejyo,F., Nakazawa,R., Miyakawa,T., Takagi,T., Kuboki,Y. and Sasaki,S.
    Studies on prolidase deficiency with a possible defect in collagen metabolism
    Tohoku J Exp Med (1981) 134, 21-28. PubMed  Europe PubMed  M
    126. 1979
  126. [YEAR:2-5-1979]Isemura,M., Hanyu,T., Gejyo,F., Nakazawa,R., Igarashi,R., Matsuo,S., Ikeda,K. and Sato,Y.
    Prolidase deficiency with imidodipeptiduria. A familial case with and without clinical symptoms
    Clin Chim Acta (2-5-1979) 93, 401-407. PubMed  Europe PubMed  M
    127. 1978
  127. Brown,S., Lalley,P.A. and Minna,J.D.
    Assignment of the gene for peptidase S (PEPS) to chromosome 4 in man and confirmation of peptidase D (PEPD) assignment to chromosome 19
    Cytogenet Cell Genet (1978) 22, 167-171. PubMed  Europe PubMed
    128. 1977
  128. Sheffield,L.J., Schlesinger,P., Faull,K., Halpern,B.J., Schier,G.M., Cotton,R.G., Hammond,J. and Danks,D.M.
    Iminopeptiduria, skin ulcerations, and edema in a boy with prolidase deficiency
    J Pediatr (1977) 91, 578-583. PubMed  Europe PubMed  M
    129. 1976
  129. Kodama,H., Umemura,S., Shimomura,M., Mizuhara,S., Arata,J., Yamamoto,Y., Yasutake,A. and Izumiya,N.
    Studies on a patient with iminopeptiduria. I. Identification of urinary iminopeptides
    Physiol Chem Phys (1976) 8, 463-473. PubMed  Europe PubMed  M
  130. McAlpine,P.J., Mohandas,T., Ray,M., Wang,H. and Hamerton,J.L.
    Assignment of the peptidase D gene locus (PEPD) to chromosome 19 in man
    Cytogenet Cell Genet (1976) 16, 204-205. PubMed  Europe PubMed
    131. 1975
  131. Jackson,S.H., Dennis,A.W. and Greenberg,M.
    Iminodipeptiduria: a genetic defect in recycling collagen; a method for determining prolidase in erythrocytes
    Can Med Assoc J (1975) 113, 759, 762-753. PubMed  Europe PubMed  PMC  EPMC  A
  132. [YEAR:24-6-1975]O'Cuinn,G. and Fottrell,P.F.
    Purification and characterization of an aminoacyl proline hydrolase from guinea-pig intestinal mucosa
    Biochim Biophys Acta (24-6-1975) 391, 388-395. PubMed  Europe PubMed
    133. 1974
  133. Baksi,K. and Radhakrishnan,A.N.
    Purification and properties of prolidase (imidodipeptidase) from monkey small intestine
    Indian J Biochem Biophys (1974) 11, 7-11. PubMed  Europe PubMed
  134. Powell,G.F., Rasco,M.A. and Maniscalco,R.M.
    A prolidase deficiency in man with iminopeptiduria
    Metabolism (1974) 23, 505-513. PubMed  Europe PubMed  M
  135. [YEAR:7-7-1974]Sjostrom,H. and Noren,O.
    Structural properties of pig intestinal proline dipeptidase
    Biochim Biophys Acta (7-7-1974) 359, 177-185. PubMed  Europe PubMed
  136. Sjostrom,H.
    Enzymatic properties of pig intestinal proline dipeptidase
    Acta Chem Scand B (1974) 28, 802-808. PubMed  Europe PubMed
    137. 1973
  137. Sjostrom,H., Noren,O. and Josefsson,L.
    Purification and specificity of pig intestinal prolidase
    Biochim Biophys Acta (1973) 327, 457-470. PubMed  Europe PubMed
    138. 1972
  138. Manao,G., Nassi,P., Cappugi,G., Camici,G. and Ramponi,G.
    Swine kidney prolidase: assay, isolation procedure, and molecular properties
    Physiol Chem Phys (1972) 4, 75-87. PubMed  Europe PubMed
    139. 1971
  139. Sjostrom,H., Noren,O. and Josefsson,L.
    Isolation and purification of a prolidase from pig intestinal mucosa
    Acta Chem Scand (1971) 25, 1911-1913. PubMed  Europe PubMed
    140. 1969
  140. Lewis,W.H. and Harris,H.
    Peptidase D (prolidase) variants in man
    Ann Hum Genet (1969) 32, 317-322. PubMed  Europe PubMed  M
    141. 1963
  141. Haschen,R.J.
    [Characterization and determination of imido- and iminopeptidase (prolidase and prolinase) in human erythrocytes]
    Acta Biol Med Ger (1963) 11, 169-173. PubMed  Europe PubMed
    142. 1957
  142. Davis,N.C. and Smith,E.L.
    Purification and some properties of prolidase of swine kidney
    J Biol Chem (1957) 224, 261-275. PubMed  Europe PubMed
    143. 1955
  143. Smith,E.L.
    [10] Dipeptidases
    Methods Enzymol (1955) 2, 93-109. DOI  V
    144. 1954
  144. Adams,E., Davis,N.C. and Smith,E.L.
    Specificity of prolidase: effect of alterations in the pyrrolidine ring of glycyl-L-proline
    J Biol Chem (1954) 208, 573-578. PubMed  Europe PubMed  P
    145. 1952
  145. Adams,E. and Smith,E.L.
    Peptidases of erythrocytes. II. Isolation and properties of prolidase
    J Biol Chem (1952) 198, 671-682. PubMed  Europe PubMed
    146. 1948
  146. Smith,E.L.
    The peptidases of skeletal, heart, and uterine muscle
    J Biol Chem (1948) 173, 553-569. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use