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Literature for peptidase M24.007: Xaa-Pro dipeptidase (eukaryote-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jaworowska,A. and Miltyk,W.<br>Where does prolidase come from and where is it heading? - A review of recent findings<br>Int J Biol Macromol (2025) 309, 143044-143044. PubMed  Europe PubMed DOI
    2. 2024
  2. Eni-Aganga,I., Lanaghan,Z.M., Ismail,F., Korolkova,O., Goodwin,J.S., Balasubramaniam,M., Dash,C. and Pandhare,J.<br>KLF6 activates Sp1-mediated prolidase transcription during TGF-beta(1) signaling<br>J Biol Chem (2024) 300, 105605-105605. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Fiorito,S., Genovese,S., Epifano,F. and Collevecchio,C.<br>Prolidase activity assays. A survey of the reported literature methodologies<br>Anal Biochem (2024) 689, 115506-115506. PubMed  Europe PubMed DOI  V
  4. Fiorito,S., Collevecchio,C., Epifano,F. and Genovese,S.<br>Targeting prolidase. A survey of the literature data to depict a structure-activity relationship frame and to address future studies for drug development<br>Bioorg Med Chem (2024) 110, 117833-117833. PubMed  Europe PubMed DOI  V
  5. Yildirim,B.B. and Kulaksizoglu,S.<br>Prolidase could be considered a sign of inflammation associated with cigarette smoking<br>Front Med (Lausanne) (2024) 11, 1347688-1347688. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Kabashima,T., Hamasaki,N., Tonooka,K. and Shibata,T.<br>A Facile Method to Determine Prolidase Activity Using a Peptide-Specific Fluorometric Reaction<br>Chem Pharm Bull (Tokyo) (2023) 71, 15-18. PubMed  Europe PubMed DOI
  7. Kayadibi,H., Koker,I.H., Gucin,Z., Senturk,H., Merzifonlu,S.C. and Ince,A.T.<br>Comparison of the optimized direct spectrophotometric serum prolidase enzyme activity assay method with the currently used spectrophotometric assay methods and liver fibrosis indexes to distinguish the early stages of liver fibrosis in patients with chronic hepatitis B infection<br>Lab Med (2023) 54, 652-658. PubMed  Europe PubMed DOI
  8. Pekkoc-Uyanik,K.C., Aslan,E.I., Kilicarslan,O., Ser,O.S., Ozyildirim,S., Yanar,F., Yildiz,A., Ozturk,O. and Yilmaz-Aydogan,H.<br>Next-generation sequencing of prolidase gene identifies novel and common variants associated with low prolidase in coronary artery ectasia<br>Mol Biol Rep (2023) 50, 1349-1365. PubMed  Europe PubMed DOI
  9. Szoka,L., Nazaruk,J., Giegiel,J. and Isidorov,V.<br>Prolidase-proline oxidase axis is engaged in apoptosis induction by birch buds flavonol santin in endometrial adenocarcinoma cell line<br>Front Mol Biosci (2023) 10, 1247536-1247536. PubMed  Europe PubMed DOI  PMC  EPMC  I
    10. 2022
  10. Czyrko-Horczak,J., Niziol,M., Forlino,A., Besio,R. and Miltyk,W.<br>The Highly Efficient Expression System of Recombinant Human Prolidase and the Effect of N-Terminal His-Tag on the Enzyme Activity<br>Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2021
  11. Eni-Aganga,I., Lanaghan,Z.M., Balasubramaniam,M., Dash,C. and Pandhare,J.<br>PROLIDASE: A Review from Discovery to its Role in Health and Disease<br>Front Mol Biosci (2021) 8, 723003-723003. PubMed  Europe PubMed DOI  PMC  EPMC  V
  12. Hajjar,N., Kabbani,M., Tannous,R., Lebre,A.S., Megarbane,A., Minari,A. and El Sayed,F.<br>Prolidase Deficiency Causing Recalcitrant Leg Ulcerations in Siblings<br>Adv Skin Wound Care (2021) 34, 1-4. PubMed  Europe PubMed DOI
  13. Palka,J., Oscilowska,I. and Szoka,L.<br>Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy<br>Amino Acids (2021) PubMed  Europe PubMed DOI  V
  14. Rossignol,F., Duarte Moreno,M.S., Benoist,J.F., Boehm,M., Bourrat,E., Cano,A., Chabrol,B., Cosson,C., Diaz,J.L.D., D'Harlingue,A., Dimmock,D., Freeman,A.F., Garcia,M.T., Garganta,C., Goerge,T., Halbach,S.S., de Laffolie,J., Lam,C.T., Martin,L., Martins,E., Meinhardt,A., Melki,I., Ombrello,A.K., Perez,N., Quelhas,D., Scott,A., Slavotinek,A.M., Soares,A.R., Stein,S.L., Sussmuth,K., Thies,J., Ferreira,C.R. and Schiff,M.<br>Quantitative analysis of the natural history of prolidase deficiency: description of 17 families and systematic review of published cases<br>Genet Med (2021) PubMed  Europe PubMed DOI  V
    15. 2020
  15. Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N.<br>Human proline specific peptidases: a comprehensive analysis<br>Biochim Biophys Acta Gen Subj (2020) 1864, 129636-129636. PubMed  Europe PubMed DOI  V
  16. Insolia,V., Priori,E.C., Gasperini,C., Coppa,F., Cocchia,M., Iervasi,E., Ferrari,B., Besio,R., Maruelli,S., Bernocchi,G., Forlino,A. and Bottone,M.G.<br>Prolidase enzyme is required for extracellular matrix integrity and impacts on postnatal cerebellar cortex development<br>J Comp Neurol (2020) 528, 61-80. PubMed  Europe PubMed DOI  K
  17. Misiura,M. and Miltyk,W.<br>Current Understanding of the Emerging Role of Prolidase in Cellular Metabolism<br>Int J Mol Sci (2020) 21, 5906-5906. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Misiura,M., Baszanowska,W., Oscilowska,I., Palka,J. and Miltyk,W.<br>Prolidase Stimulates Proliferation and Migration through Activation of the PI3K/Akt/mTOR Signaling Pathway in Human Keratinocytes<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Razmi,T., Jindal,A.K., Arora,K., Joshi,V., Suri,D. and De,D.<br>Refractory leg ulcers in prolidase deficiency with antiphospholipid antibody positivity responding to aspirin-hydroxychloroquine-vitamin C combination therapy<br>Dermatol Ther (2020) , e14156-e14156. PubMed  Europe PubMed DOI
  20. Wator,E., Rutkiewicz,M., Weiss,M.S. and Wilk,P.<br>Co-expression with chaperones can affect protein 3D structure as exemplified by loss-of-function variants of human prolidase<br>FEBS Lett (2020) 594, 3045-3056. PubMed  Europe PubMed DOI
  21. Wilk,P., Wator,E. and Weiss,M.S.<br>Prolidase - A protein with many faces<br>Biochimie (2020) 183, 3-12. PubMed  Europe PubMed DOI  V
  22. Zareba,I., Huynh,T.Y.L., Kazberuk,A., Teul,J., Klupczynska,A., Matysiak,J., Surazynski,A. and Palka,J.<br>Overexpression of Prolidase Induces Autophagic Death in MCF-7 Breast Cancer Cells<br>Cell Physiol Biochem (2020) 54, 875-887. PubMed  Europe PubMed DOI
    23. 2019
  23. Kiratli Nalbant,E., Karaosmanoglu,N., Kutlu,O., Ceylaner,S. and Eksioglu,H.M.<br>A rare case of prolidase deficiency with situs inversus totalis, identified by a novel mutation in the PEPD gene<br>JAAD Case Rep (2019) 5, 436-438. PubMed  Europe PubMed DOI  PMC  EPMC  M
  24. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.<br>A recombinant human protein targeting HER2 overcomes drug resistance in HER2-positive breast cancer<br>Sci Transl Med (2019) 11, eaav1620-eaav1620. PubMed  Europe PubMed DOI
  25. Ysrayl,B.B., Balasubramaniam,M., Albert,I., Villalta,F., Pandhare,J. and Dash,C.<br>A novel role of prolidase in cocaine-mediated breach in the barrier of brain microvascular endothelial cells<br>Sci Rep (2019) 9, 2567-2567. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2018
  26. Bhatnager,R. and Dang,A.S.<br>Comprehensive in-silico prediction of damage associated SNPs in human prolidase gene<br>Sci Rep (2018) 8, 9430-9430. PubMed  Europe PubMed DOI  PMC  EPMC  M
  27. Wilk,P., Uehlein,M., Piwowarczyk,R., Dobbek,H., Mueller,U. and Weiss,M.S.<br>Structural Basis for Prolidase Deficiency Disease Mechanisms<br>FEBS J (2018) 285, 3422-3441. PubMed  Europe PubMed DOI  M  S
    28. 2017
  28. Tereshchenkova,V.F., Goptar,I.A., Zhuzhikov,D.P., Belozersky,M.A., Dunaevsky,Y.E., Oppert,B., Filippova,I.Y. and Elpidina,E.N.<br>Prolidase is a critical enzyme for complete gliadin digestion in Tenebrio molitor larvae<br>Arch Insect Biochem Physiol (2017) 95 PubMed  Europe PubMed DOI
  29. Wilk,P., Uehlein,M., Kalms,J., Dobbek,H., Mueller,U. and Weiss,M.S.<br>Substrate specificity and reaction mechanism of human prolidase<br>FEBS J (2017) 284, 2870-2885. PubMed  Europe PubMed DOI  S
  30. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.<br>PEPD is a pivotal regulator of p53 tumor suppressor<br>Nat Commun (2017) 8, 2052-2052. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Yun,H., Lee,S., Kim,S., Yu,J., Lee,N., Lee,J., Kim,N.D., Yu,C. and Rho,J.<br>Improved hydrolysis of organophosphorus compounds by engineered human prolidases<br>Protein Pept Lett (2017) 24, 617-625. PubMed  Europe PubMed DOI
    32. 2016
  32. Adisen,E., Erduran,F.B., Ezgu,F.S., Kasapkara,CS., Besio,R., Forlino,A. and Gurer,M.A.<br>A rare cause of lower extremity ulcers: prolidase deficiency<br>Int J Low Extrem Wounds (2016) 15, 86-91. PubMed  Europe PubMed DOI  M
  33. Hintze,J.P., Kirby,A., Torti,E. and Batanian,J.R.<br>Prolidase deficiency in a Mexican-American patient identified by array CGH reveals a novel and the largest PEPD gene deletion<br>Mol Syndr (2016) 7, 80-86. PubMed  Europe PubMed DOI  M
  34. Suri,D., Pandit,R.A., Saini,A.G., Dogra,S., Gupta,A., Rawat,A., Dwivedi,I., Masih,S. and Attri,S.V.<br>A novel splice acceptor site mutation (IVS11 G > A) of PEPD gene causing prolidase deficiency associated with hyperimmunoglobulinemia E<br>Gene Rep (2016) 4, 29-32. DOI  M
  35. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.<br>Dual inhibition of ErbB1 and ErbB2 in cancer by recombinant human prolidase mutant hPEPD-G278D<br>Oncotarget (2016) 7, 42340-42352. PubMed  Europe PubMed DOI
    36. 2015
  36. Besio,R., Maruelli,S., Gioia,R., Villa,I., Grabowski,P., Gallagher,O., Bishop,N.J., Foster,S., De Lorenzi,E., Colombo,R., Diaz,J.L., Moore-Barton,H., Deshpande,C., Aydin,H.I., Tokatli,A., Kwiek,B., Kasapkara,C.S., Adisen,E.O., Gurer,M.A., Di Rocco,M., Phang,J.M., Gunn,T.M., Tenni,R., Rossi,A. and Forlino,A.<br>Lack of prolidase causes a bone phenotype both in human and in mouse<br>Bone (2015) 72C, 53-64. PubMed  Europe PubMed DOI  M
  37. Lubick,K.J., Robertson,S.J., McNally,K.L., Freedman,B.A., Rasmussen,A.L., Taylor,R.T., Walts,A.D., Tsuruda,S., Sakai,M., Ishizuka,M., Boer,E.F., Foster,E.C., Chiramel,A.I., Addison,C.B., Green,R., Kastner,D.L., Katze,M.G., Holland,S.M., Forlino,A., Freeman,A.F., Boehm,M., Yoshii,K. and Best,S.M.<br>Flavivirus antagonism of type I interferon signaling reveals prolidase as a regulator of IFNAR1 surface expression<br>Cell Host Microbe (2015) 18, 61-74. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Rezk,P.E., Zdenka,P., Sabnekar,P., Kajih,T., Mata,D.G., Wrobel,C., Cerasoli,D.M. and Chilukuri,N.<br>An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents<br>Drug Chem Toxicol (2015) 38, 37-43. PubMed  Europe PubMed DOI
  39. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.<br>Inhibition of ERBB2-overexpressing tumors by recombinant human prolidase and its enzymatically inactive mutant<br>EBioMedicine (2015) 2, 396-405. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2014
  40. Insolia,V. and Piccolini,V.M.<br>Brain morphological defects in prolidase deficient mice: first report<br>Eur J Histochem (2014) 58, 2417-2417. PubMed  Europe PubMed DOI  M
  41. Lacarbonara,M., Cazzolla,A.P., Lacarbonara,V.A., DiVenere,D., Capogreco,M. and Marzo,G.<br>Prolidase deficiency: dento-facial aspects in a paediatric patient<br>Eur J Paediatr Dent (2014) 15, 224-228. PubMed  Europe PubMed  M
  42. Lin,Q.-Z., Yin,R.-X., Wu,J., Guo,T., Wang,W., Sun,J.-Q., Shi,G.-Y., Shen,S.-W., Wu,J.-Z. and Pan,S.-L.<br>Sex-specific association of the peptidase D gene rs731839 polymorphism and serum lipid levels in the Mulao and Han populations<br>Int J Clin Exp Pathol (2014) 7, 4156-4172. PubMed  Europe PubMed  M
  43. Pohl,M.O., Edinger,T.O. and Stertz,S.<br>Prolidase is required for early trafficking events during influenza A virus entry<br>J Virol (2014) 88, 11271-11283. PubMed  Europe PubMed DOI
    44. 2013
  44. Aleti,V., Reddy,G.B., Parikh,K., Arun,P. and Chilukuri,N.<br>Persistent and high-level expression of human liver prolidase in vivo in mice using adenovirus<br>Chem Biol Interact (2013) 203, 191-195. PubMed  Europe PubMed DOI  U
  45. Besio,R., Gioia,R., Cossu,F., Monzani,E., Nicolis,S., Cucca,L., Profumo,A., Casella,L., Tenni,R., Bolognesi,M., Rossi,A. and Forlino,A.<br>Kinetic and structural evidences on human prolidase pathological mutants suggest strategies for enzyme functional rescue<br>PLoS ONE (2013) 8, e58792-e58792. PubMed  Europe PubMed DOI  PMC  EPMC  M
  46. Besio,R., Baratto,M.C., Gioia,R., Monzani,E., Nicolis,S., Cucca,L., Profumo,A., Casella,L., Basosi,R., Tenni,R., Rossi,A. and Forlino,A.<br>A Mn(II)-Mn(II) center in human prolidase<br>Biochim Biophys Acta (2013) 1834, 197-204. PubMed  Europe PubMed DOI
  47. Chandrasekaran,L., Belinskaya,T. and Saxena,A.<br>In vitro characterization of organophosphorus compound hydrolysis by native and recombinant human prolidase<br>Toxicol In Vitro (2013) 27, 499-506. PubMed  Europe PubMed DOI  U
  48. Pandit,R.A., Chen,C.J., Butt,T.A. and Islam,N.<br>Identification and analysis of a novel mutation in PEPD gene in two Kashmiri siblings with prolidase enzyme deficiency<br>Gene (2013) 516, 316-319. PubMed  Europe PubMed DOI  M
  49. Yang,L., Li,Y., Ding,Y., Choi,K.S., Kazim,A.L. and Zhang,Y.<br>Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling<br>J Biol Chem (2013) 288, 2365-2375. PubMed  Europe PubMed DOI
    50. 2012
  50. Kitchener,R.L. and Grunden,A.M.<br>Prolidase function in proline metabolism and its medical and biotechnological applications<br>J Appl Microbiol (2012) 113, 233-247. PubMed  Europe PubMed DOI  V
  51. Kodama,H.<br>Xaa-Pro dipeptidase (eukaryotes)<br>[ISSN:978-0-12-407743-0] (2012) 3, 1507-1514. DOI
    52. 2011
  52. Alberto,M.E., Leopoldini,M. and Russo,N.<br>Can human prolidase enzyme use different metals for full catalytic activity?<br>Inorg Chem (2011) 50, 3394-3403. PubMed  Europe PubMed DOI
  53. Besio,R., Monzani,E., Gioia,R., Nicolis,S., Rossi,A., Casella,L. and Forlino,A.<br>Improved prolidase activity assay allowed enzyme kinetic characterization and faster prolidase deficiency diagnosis<br>Clin Chim Acta (2011) 412, 1814-1820. PubMed  Europe PubMed DOI  A
  54. Jung,S., Silvius,D., Nolan,K.A., Borchert,G.L., Millet,Y.H., Phang,J.M. and Gunn,T.M.<br>Developmental cardiac hypertrophy in a mouse model of prolidase deficiency<br>Birth Defects Res A Clin Mol Teratol (2011) 91, 204-217. PubMed  Europe PubMed DOI  M
    55. 2010
  55. Besio,R., Alleva,S., Forlino,A., Lupi,A., Meneghini,C., Minicozzi,V., Profumo,A., Stellato,F., Tenni,R. and Morante,S.<br>Identifying the structure of the active sites of human recombinant prolidase<br>Eur Biophys J (2010) 39, 935-945. PubMed  Europe PubMed DOI
  56. Falik-Zaccai,T.C., Khayat,M., Luder,A., Frenkel,P., Magen,D., Brik,R., Gershoni-Baruch,R. and Mandel,H.<br>A broad spectrum of developmental delay in a large cohort of prolidase deficiency patients demonstrates marked interfamilial and intrafamilial phenotypic variability<br>Am J Med Genet B Neuropsychiatr Genet (2010) 153B, 46-56. PubMed  Europe PubMed DOI  M
  57. Klar,A., Navon-Elkan,P., Rubinow,A., Branski,D., Hurvitz,H., Christensen,E., Khayat,M. and Falik-Zaccai,T.C.<br>Prolidase deficiency: it looks like systemic lupus erythematosus but it is not<br>Eur J Pediatr (2010) 169, 727-732. PubMed  Europe PubMed DOI  M
    58. 2009
  58. Uramatsu,S., Liu,G., Yang,Q., Uramatsu,M., Chi,H., Lu,J., Yamashita,K. and Kodama,H.<br>Characterization of prolidase I and II purified from normal human erythrocytes: comparison with prolidase in erythrocytes from a patient with prolidase deficiency<br>Amino Acids (2009) 37, 543-551. PubMed  Europe PubMed DOI
    59. 2008
  59. Colonna,C., Conti,B., Perugini,P., Pavanetto,F., Modena,T., Dorati,R., Iadarola,P. and Genta,I.<br>Site-directed PEGylation as successful approach to improve the enzyme replacement in the case of prolidase<br>Int J Pharm (2008) 358, 230-237. PubMed  Europe PubMed DOI  U
  60. Lupi,A., Tenni,R., Rossi,A., Cetta,G. and Forlino,A.<br>Human prolidase and prolidase deficiency: an overview on the characterization of the enzyme involved in proline recycling and on the effects of its mutations<br>Amino Acids (2008) 35, 739-752. PubMed  Europe PubMed DOI  V
  61. Surazynski,A., Donald,S.P., Cooper,S.K., Whiteside,M.A., Salnikow,K., Liu,Y. and Phang,J.M.<br>Extracellular matrix and HIF-1 signaling: the role of prolidase<br>Int J Cancer (2008) 122, 1435-1440. PubMed  Europe PubMed DOI
  62. Zhou,L., Yuan,J., Yin,J. and Wang,E.<br>Kinetic study of prolidase activity in erythrocytes against different substrates using capillary electrophoresis with electrochemiluminescence detection<br>J Chromatogr A (2008) 1200, 255-259. PubMed  Europe PubMed DOI  A
    63. 2007
  63. Liu,G., Nakayama,K., Awata,S., Tang,S., Kitaoka,N., Manabe,M. and Kodama,H.<br>Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors<br>Pediatr Res (2007) 62, 54-59. PubMed  Europe PubMed DOI
  64. Luder,A.S., Mandel,H., Khayat,M., Gurevich,I., Frankel,P., Rivlin,J. and Falik-Zaccai,T.C.<br>Chronic lung disease and cystic fibrosis phenotype in prolidase deficiency: a newly recognized association<br>J Pediatr (2007) 150, 656-658. PubMed  Europe PubMed DOI  M
  65. Mittal,S., Song,X., Vig,B.S. and Amidon,G.L.<br>Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma<br>Pharm Res (2007) 24, 1290-1298. PubMed  Europe PubMed DOI
  66. [YEAR:29-6-2007]Uramatsu,M., Liu,G., Uramatsu,S., Zhang,M., Wang,W., Nakayama,K., Manabe,M. and Kodama,H.<br>Different effects of sulfur amino acids on prolidase and prolinase activity in normal and prolidase-deficient human erythrocytes<br>Clin Chim Acta (29-6-2007) 375, 129-135. PubMed  Europe PubMed DOI
    67. 2006
  67. Hershkovitz,T., Hassoun,G., Indelman,M., Shlush,L.I., Bergman,R., Pollack,S. and Sprecher,E.<br>A homozygous missense mutation in PEPD encoding peptidase D causes prolidase deficiency associated with hyper-IgE syndrome<br>Clin Exp Dermatol (2006) 31, 435-440. PubMed  Europe PubMed DOI  M
  68. Kavala,M., Zindanci,I., Sudogan,S., Turkoglu,Z. and Sarigul,S.<br>Ulcus cruris associated with prolidase deficiency<br>Dermatol Online J (2006) 12, 24-24. PubMed  Europe PubMed  M
  69. [YEAR:27-10-2006]Kurien,B.T., Patel,N.C., Porter,A.C., D'Souza,A., Miller,D., Matsumoto,H., Wang,H. and Scofield,R.H.<br>Prolidase deficiency and the biochemical assays used in its diagnosis<br>Anal Biochem (27-10-2006) 349, 165-175. PubMed  Europe PubMed DOI  A  V
  70. [YEAR:1-11-2006]Lupi,A., Della Torre,S., Campari,E., Tenni,R., Cetta,G., Rossi,A. and Forlino,A.<br>Human recombinant prolidase from eukaryotic and prokaryotic sources. Expression, purification, characterization and long-term stability studies<br>FEBS J (1-11-2006) 273, 5466-5478. PubMed  Europe PubMed DOI  E
  71. Lupi,A., Rossi,A., Campari,E., Pecora,F., Lund,A.M., Elcioglu,N.H., Gultepe,M., Di Rocco,M., Cetta,G. and Forlino,A.<br>Molecular characterisation of six patients with prolidase deficiency: identification of the first small duplication in the prolidase gene and of a mutation generating symptomatic and asymptomatic outcomes within the same family<br>J Med Genet (2006) 43, e58-e58. PubMed  Europe PubMed DOI  M
  72. [YEAR:15-3-2006]Wang,H., Kurien,B.T., Lundgren,D., Patel,N.C., Kaufman,K.M., Miller,D.L., Porter,A.C., D'Souza,A., Nye,L., Tumbush,J., Hupertz,V., Kerr,D.S., Kurono,S., Matsumoto,H. and Scofield,R.H.<br>A nonsense mutation of PEPD in four Amish children with prolidase deficiency<br>Am J Med Genet A (15-3-2006) 140, 580-585. PubMed  Europe PubMed DOI  M
  73. [YEAR:22-8-2006]Wang,S.H., Zhi,Q.W. and Sun,M.J.<br>Dual activities of human prolidase<br>Toxicol In Vitro (22-8-2006) 20, 71-77. PubMed  Europe PubMed DOI  E
    74. 2005
  74. Liu,G., Nakayama,K., Sagara,Y., Awata,S., Yamashita,K., Manabe,M. and Kodama,H.<br>Characterization of prolidase activity in erythrocytes from a patient with prolidase deficiency: Comparison with prolidase I and II purified from normal human erythrocytes<br>Clin Biochem (2005) 38, 625-631. PubMed  Europe PubMed DOI
  75. [YEAR:30-6-2005]Lupi,A., Rossi,A., Vaghi,P., Gallanti,A., Cetta,G. and Forlino,A.<br>N-Benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase<br>Biochim Biophys Acta Mol Cell Res (30-6-2005) 1744, 157-163. PubMed  Europe PubMed DOI  I
  76. Mittal,S., Song,X., Vig,B.S., Landowski,C.P., Kim,I., Hilfinger,J.M. and Amidon,G.L.<br>Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs<br>Mol Pharm (2005) 2, 37-46. PubMed  Europe PubMed DOI
  77. [YEAR:20-1-2005]Perugini,P., Hassan,K., Genta,I., Modena,T., Pavanetto,F., Cetta,G., Zanone,C., Iadarola,P., Asti,A. and Conti,B.<br>Intracellular delivery of liposome-encapsulated prolidase in cultured fibroblasts from prolidase-deficient patients<br>J Control Release (20-1-2005) 102, 181-190. PubMed  Europe PubMed DOI
  78. [YEAR:15-9-2005]Surazynski,A., Liu,Y., Miltyk,W. and Phang,J.M.<br>Nitric oxide regulates prolidase activity by serine/threonine phosphorylation<br>J Cell Biochem (15-9-2005) 96, 1086-1094. PubMed  Europe PubMed DOI
  79. Wang,S.H., Zhi,Q.W. and Sun,M.J.<br>Purification and characterization of recombinant human liver prolidase expressed in Saccharomyces cerevisiae<br>Arch Toxicol (2005) 79, 253-259. PubMed  Europe PubMed DOI  E
    80. 2004
  80. Liu,G., Nakayama,K., Awata,S., Wang,W., Yamashita,K., Manabe,M. and Kodama,H.<br>Effects of amino acids and its metabolites on prolidase activity against various iminodipeptides in erythrocytes from normal human and a patient with prolidase deficiency<br>Clin Chim Acta (2004) 350, 211-217. PubMed  Europe PubMed DOI
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