| Activity |
|---|
| Catalytic type | Metallo |
| Peplist | Included in the Peplist with identifier PL00221 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.56
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (9 cleavages) |
| Activity status | human: active (Roth, 2004)
mouse: active (Saric et al., 1994)
|
| Physiology | May contribute to intracellular degradation of insulin and other proteins. Genetic and in vitro evidence suggests that reduced activity of the enzyme may contribute to Alzheimer"s disease and type 2 diabetes mellitus (Farris et al., 2003). |
| Knockout | Mice with homozygous deficiency of the gene have been characterised by Farris et al., 2003. They showed abnormally low catabolism of the Alzheimer"s A-beta peptide and insulin. Polymorphism may be associated with human type 2 diabetes (Karamohamed et al., 2003). |
| Pathways |
KEGG | Alzheimer's disease |
|
Other databases
| WIKIPEDIA | http://en.wikipedia.org/wiki/Insulin_degrading_enzyme |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | l/v/l/r lfrg/-/-/- (based on 101 cleavages) |
