Literature for peptidase M16.002: insulysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Bertocci,B., Yilmaz,A., Waeckel-Enee,E., Guerrera,C., Roger,K., Toure,L. and van Endert,P.M. Insulin-Degrading Enzyme Regulates mRNA Processing and May Interact with the CCR4-NOT Complex Cells (2025) 14 PubMed Europe PubMed DOI PMC EPMC
Mancl,J.M., Liang,W.G., Bayhi,N.L., Wei,H., Carragher,B., Potter,C.S. and Tang,W.J. Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC

2024

Bessard,M.A., Moser,A., Waeckel-Enee,E., Lindo,V., Gdoura,A., You,S., Wong,F.S., Greer,F. and van Endert,P. Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes Front Immunol (2024) 15, 1474453-1474453. PubMed Europe PubMed DOI PMC EPMC
Geijtenbeek,K.W., Aranda,A.S., Sanz,A.S., Janzen,J., Bury,A.E., Kors,S., Al Amery,N., Schmitz,N.C.M., Reits,E.A.J. and Schipper-Krom,S. Insulin-Degrading Enzyme Efficiently Degrades polyQ Peptides but not Expanded polyQ Huntingtin Fragments J Huntingtons Dis (2024) 13, 201-214. PubMed Europe PubMed DOI
Issac,L., Dolev,D., Irit,B., Assaf,D. and Levy,I. Assessment of insulin-degrading enzyme inhibitor for the treatment of corneal erosion in a rat model Graefes Arch Clin Exp Ophthalmol (2024) PubMed Europe PubMed DOI I
Metwally,H.M., Younis,N.M., Abdel-Latif,E. and El-Rayyes,A. New thiazole, thiophene and 2-pyridone compounds incorporating dimethylaniline moiety: synthesis, cytotoxicity, ADME and molecular docking studies BMC Chem (2024) 18, 52-52. PubMed Europe PubMed DOI PMC EPMC
Yuan,T., Wang,H., Wang,Y., Dong,S., Ge,J., Li,Z. and Sun,S. Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head Mol Med (2024) 30, 111-111. PubMed Europe PubMed DOI PMC EPMC
Zukowska,J., Moss,S.J., Subramanian,V. and Acharya,K.R. Molecular basis of selective amyloid-beta degrading enzymes in Alzheimer's disease FEBS J (2024) 291, 2999-3029. PubMed Europe PubMed DOI V

2023

Ambrozova,L., Zeman,T., Janout,V., Janoutova,J., Lochman,J. and Sery,O. Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report J Clin Lab Anal (2023) 37, e24949-e24949. PubMed Europe PubMed DOI PMC EPMC
Corraliza-Gomez,M., Bermejo,T., Lilue,J., Rodriguez-Iglesias,N., Valero,J., Cozar-Castellano,I., Arranz,E., Sanchez,D. and Ganfornina,M.D. Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging J Neuroinflammation (2023) 20, 233-233. PubMed Europe PubMed DOI PMC EPMC
Rao,F., Zhang,Z. and Li,J. Dynamical analysis of a glucose-insulin regulatory system with insulin-degrading enzyme and multiple delays J Math Biol (2023) 87, 73-73. PubMed Europe PubMed DOI
Rowland,H.A., Moxon,S.R., Corbett,N.J., Hanson,K., Fisher,K., Kellett,K.A.B. and Hooper,N.M. Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-beta deposition Neuronal Signal (2023) 7, NS20230016-NS20230016. PubMed Europe PubMed DOI PMC EPMC
Tian,Y., Jing,G. and Zhang,M. Insulin-degrading enzyme: Roles and pathways in ameliorating cognitive impairment associated with Alzheimer's disease and diabetes Ageing Res Rev (2023) 90, 101999-101999. PubMed Europe PubMed DOI V
Tundo,G.R., Grasso,G., Persico,M., Tkachuk,O., Bellia,F., Bocedi,A., Marini,S., Parravano,M., Graziani,G., Fattorusso,C. and Sbardella,D. The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design Biomolecules (2023) 13 PubMed Europe PubMed DOI PMC EPMC
Yilmaz,A., Guerrera,C., Waeckel-Enee,E., Lipecka,J., Bertocci,B. and van Endert,P. Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins Biomolecules (2023) 13 PubMed Europe PubMed DOI PMC EPMC

2022

Azam,M.S., Wahiduzzaman,M., Reyad-Ul-Ferdous,M., Islam,M.N. and Roy,M. Inhibition of Insulin Degrading Enzyme to Control Diabetes Mellitus and its Applications on some Other Chronic Disease: a Critical Review Pharm Res (2022) 39, 611-629. PubMed Europe PubMed DOI V
Corraliza-Gomez,M., Lillo,C., Cozar-Castellano,I., Arranz,E., Sanchez,D. and Ganfornina,M.D. Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells Cells (2022) 11 PubMed Europe PubMed DOI PMC EPMC
Distefano,A., Caruso,G., Oliveri,V., Bellia,F., Sbardella,D., Zingale,G.A., Caraci,F. and Grasso,G. Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme ACS Chem Neurosci (2022) 13, 1588-1593. PubMed Europe PubMed DOI PMC EPMC
Distefano,A., Antonio Zingale,G. and Grasso,G. An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme Anal Bioanal Chem (2022) 414, 4793-4802. PubMed Europe PubMed DOI
Lesire,L., Leroux,F., Deprez-Poulain,R. and Deprez,B. Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer? Cells (2022) 11 PubMed Europe PubMed DOI PMC EPMC V
Martin-Martin,Y., Perez-Garcia,A., Torrecilla-Parra,M., Fernandez-de Frutos,M., Pardo-Marques,V., Casarejos,M.J., Busto,R. and Ramirez,C.M. New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs Cells (2022) 11 PubMed Europe PubMed DOI PMC EPMC
Pablos,M., Casanueva-Alvarez,E., Gonzalez-Casimiro,C.M., Merino,B., Perdomo,G. and Cozar-Castellano,I. Primary Cilia in Pancreatic beta- and alpha-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme Front Endocrinol (Lausanne) (2022) 13, 922825-922825. PubMed Europe PubMed DOI PMC EPMC V
Tundo,G.R., Sbardella,D., Oddone,F., Grasso,G., Marini,S., Atzori,M.G., Santoro,A.M., Milardi,D., Bellia,F., Macari,G., Graziani,G., Polticelli,F., Cascio,P., Parravano,M. and Coletta,M. Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug Biomolecules (2022) 12 PubMed Europe PubMed DOI PMC EPMC K I

2021

Adamek,R.N., Suire,C.N., Stokes,R.W., Brizuela,M.K., Cohen,S.M. and Leissring,M.A. Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme ChemMedChem (2021) PubMed Europe PubMed DOI I
Hostachy,S., Utesch,T., Franke,K., Dornan,G.L., Furkert,D., Turkaydin,B., Haucke,V., Sun,H. and Fiedler,D. Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs Chem Sci (2021) 12, 10696-10702. PubMed Europe PubMed DOI PMC EPMC
Inoue,Y., Masuda,T., Misumi,Y., Ando,Y. and Ueda,M. Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus Neurosci Lett (2021) 762, 136136-136136. PubMed Europe PubMed DOI
Leissring,M.A., Gonzalez-Casimiro,C.M., Merino,B., Suire,C.N. and Perdomo,G. Targeting Insulin-Degrading Enzyme in Insulin Clearance Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC V
Leissring,M.A. Insulin-Degrading Enzyme: Paradoxes and Possibilities Cells (2021) 10 PubMed Europe PubMed DOI PMC EPMC
Li,C., Wang,Y., Zhu,G., Shang,Y., Jiefang,K. and Li,J. IL-6 induced enhanced clearance of proANP and ANP by insulin-degrading enzyme in T1DM mouse Biochem Cell Biol (2021) PubMed Europe PubMed DOI
Nash,Y., Ganoth,A., Borenstein-Auerbach,N., Levy-Barazany,H., Goldsmith,G., Kopelevich,A., Pozyuchenko,K., Sakhneny,L., Lazdon,E., Blanga-Kanfi,S., Alhadeff,R., Benromano,T., Landsman,L., Tsfadia,Y. and Frenkel,D. From virus to diabetes therapy: Characterization of a specific insulin-degrading enzyme inhibitor for diabetes treatment FASEB J (2021) 35, e21374-e21374. PubMed Europe PubMed DOI I
Ramaraju,B., Nelson,S.L., Zheng,W., Ghirlando,R. and Deshmukh,L. Quantitative NMR Study of Insulin-Degrading Enzyme Using Amyloid-beta and HIV-1 p6 Elucidates Its Chaperone Activity Biochemistry (2021) PubMed Europe PubMed DOI
Sousa,L., Guarda,M., Meneses,M.J., Macedo,M.P. and Vicente Miranda,H. Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases J Pathol (2021) PubMed Europe PubMed DOI V
Waclawczyk,D., Silberring,J. and Grasso,G. The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism J Enzyme Inhib Med Chem (2021) 36, 183-187. PubMed Europe PubMed DOI PMC EPMC
Zheng,Q., Kebede,M.T., Lee,B., Krasinski,C.A., Islam,S., Wurfl,L.A., Kemeh,M.M., Ivancic,V.A., Jakobsche,C.E., Spratt,D.E. and Lazo,N.D. Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme Antioxidants (Basel) (2021) 10 PubMed Europe PubMed DOI PMC EPMC I

2020

Bernstein,H.G., Keilhoff,G., Dobrowolny,H. and Steiner,J. Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme's implication for Alzheimer s disease pathology? Eur Arch Psychiatry Clin Neurosci (2020) 270, 495-496. PubMed Europe PubMed DOI
Fu,H., Liu,B., Li,L. and Lemere,C.A. Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme Neuroscience (2020) 443, 30-43. PubMed Europe PubMed DOI
Kim,N. and Lee,H.J. Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease Biomed Res Int (2020) 2020, 2010728-2010728. PubMed Europe PubMed DOI PMC EPMC V
Lauer,A.A., Mett,J., Janitschke,D., Thiel,A., Stahlmann,C.P., Bachmann,C.M., Ritzmann,F., Schrul,B., Muller,U.C., Stein,R., Riemenschneider,M., Grimm,H.S., Hartmann,T. and Grimm,M.O.W. Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease Aging Cell (2020) , e13264-e13264. PubMed Europe PubMed DOI
Merino,B., Fernandez-Diaz,C.M., Parrado-Fernandez,C., Gonzalez-Casimiro,C.M., Postigo-Casado,T., Lobaton,C.D., Leissring,M.A., Cozar-Castellano,I. and Perdomo,G. Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice Metabolism (2020) 113, 154352-154352. PubMed Europe PubMed DOI
Minchenko,D.O., Khita,O.O., Tsymbal,D.O., Danilovskyi,S.V., Rudnytska,O.V., Halkin,O.V., Kryvdiuk,I.V., Smeshkova,M.V., Yakymchuk,M.M., Bezrodnyi,B.H. and Minchenko,O.H. Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation Endocr Regul (2020) 54, 183-195. PubMed Europe PubMed DOI
Suire,C.N., Brizuela,M.K. and Leissring,M.A. Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin Methods Protoc (2020) 3 PubMed Europe PubMed DOI PMC EPMC

2019

Bellia,F., Lanza,V., Ahmed,I.M.M., Garcia-Vinuales,S., Veiss,E., Arizzi,M., Calcagno,D., Milardi,D. and Grasso,G. Site directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus E1-like activity: the role of metal ions Metallomics (2019) 11, 278-281. PubMed Europe PubMed DOI
Borges,D.O., Meneses,M.J., Dias,T.R., Martins,F.O., Oliveira,P.F., Alves,M.G. and Macedo,M.P. Data on metabolic profile of insulin-degrading enzyme knockout mice Data Brief (2019) 25, 104023-104023. PubMed Europe PubMed DOI PMC EPMC K
Fernandez-Diaz,C.M., Merino,B., Lopez-Acosta,J.F., Cidad,P., de la Fuente,M.A., Lobaton,C.D., Moreno,A., Leissring,M.A., Perdomo,G. and Cozar-Castellano,I. Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity Am J Physiol Endocrinol Metab (2019) 317, E805-E805. PubMed Europe PubMed DOI K
Leng,Q.Y., Zheng,J.H., Xu,H.D., Adu-Asiamah,P., Zhang,Y., Du,B.W. and Zhang,L. [Cloning and expression analysis of chicken circular transcript of insulin degrading enzyme gene] Yi Chuan (2019) 41, 1129-1137. PubMed Europe PubMed DOI
Leroux,F., Bosc,D., Beghyn,T., Hermant,P., Warenghem,S., Landry,V., Pottiez,V., Guillaume,V., Charton,J., Herledan,A., Urata,S., Liang,W., Sheng,L., Tang,W.J., Deprez,B. and Deprez-Poulain,R. Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening Eur J Med Chem (2019) 179, 557-566. PubMed Europe PubMed DOI I
Maianti,J.P., Tan,G.A., Vetere,A., Welsh,A.J., Wagner,B.K., Seeliger,M.A. and Liu,D.R. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme Nat Chem Biol (2019) 15, 565-574. PubMed Europe PubMed DOI S I
Meneses,M.J., Borges,D.O., Dias,T.R., Martins,F.O., Oliveira,P.F., Macedo,M.P. and Alves,M.G. Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality Mol Cell Endocrinol (2019) 486, 11-17. PubMed Europe PubMed DOI K
Zhang,S., Chen,L., Li,F., Li,N., Feng,Y. and Xiao,L. Divergent copies of a Cryptosporidium parvum-specific subtelomeric gene Microorganisms (2019) 7 PubMed Europe PubMed DOI

2018

Grasso,G. Commentary on Ivancic et al.: Enzyme Kinetics from Circular Dichroism of Insulin Reveals Mechanistic Insights into the Regulation of Insulin-degrading Enzyme Biosci Rep (2018) 38, BSR20181555-BSR20181555. PubMed Europe PubMed DOI
Hayrabedyan,S., Todorova,K., Spinelli,M., Barnea,E.R. and Mueller,M. The core sequence of PIF competes for insulin/amyloid beta in insulin degrading enzyme: potential treatment for Alzheimer's disease Oncotarget (2018) 9, 33884-33895. PubMed Europe PubMed DOI PMC EPMC
Ivancic,V.A., Krasinski,C.A., Zheng,Q., Meservier,R.J., Spratt,D.E. and Lazo,N.D. Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme Biosci Rep (2018) 38, BSR20181416-BSR20181416. PubMed Europe PubMed DOI
Krasinski,C.A., Ivancic,V.A., Zheng,Q., Spratt,D.E. and Lazo,N.D. Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Abeta42 ACS Omega (2018) 3, 13275-13282. PubMed Europe PubMed DOI PMC EPMC I
Krasinski,C.A., Zheng,Q., Ivancic,V.A., Spratt,D.E. and Lazo,N.D. The longest amyloid-beta precursor protein intracellular domain produced with Abeta42 forms beta-sheet-containing monomers that self-assemble and are proteolyzed by insulin-degrading enzyme ACS Chem Neurosci (2018) 9, 2892-2897. PubMed Europe PubMed DOI
Kurochkin,I.V., Guarnera,E. and Berezovsky,I.N. Insulin-degrading enzyme in the fight against Alzheimer's disease Trends Pharmacol Sci (2018) 39, 49-58. PubMed Europe PubMed DOI
Lai,R., Tang,W.J. and Li,H. Catalytic mechanism of amyloid-beta peptide degradation by insulin degrading enzyme: insights from quantum mechanics and molecular mechanics style Moller-Plesset second order perturbation theory calculation J Chem Inf Model (2018) 58, 1926-1934. PubMed Europe PubMed DOI
Stefanidis,L., Fusco,N.D., Cooper,S.E., Smith-Carpenter,J.E. and Alper,B.J. Molecular determinants of substrate specificity in human insulin-degrading enzyme Biochemistry (2018) 57, 4903-4914. PubMed Europe PubMed DOI
Suire,C.N., Nainar,S., Fazio,M., Kreutzer,A.G., Paymozd-Yazdi,T., Topper,C.L., Thompson,C.R. and Leissring,M.A. Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display PLoS ONE (2018) 13, e0193101-e0193101. PubMed Europe PubMed DOI I
Villa-Perez,P., Merino,B., Fernandez-Diaz,C.M., Cidad,P., Lobaton,C.D., Moreno,A., Muturi,H.T., Ghadieh,H.E., Najjar,S.M., Leissring,M.A., Cozar-Castellano,I. and Perdomo,G. Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice Metabolism (2018) 88, 1-11. PubMed Europe PubMed DOI K
Yang,D., Qin,W., Shi,X., Zhu,B., Xie,M., Zhao,H., Teng,B., Wu,Y., Zhao,R., Yin,F., Ren,P., Liu,L. and Li,Z. Stabilized beta-hairpin peptide inhibits insulin degrading enzyme J Med Chem (2018) 61, 8174-8185. PubMed Europe PubMed DOI I
Zhang,Y. and Wang,P. Age-related increase of insulin-degrading enzyme is inversely correlated with cognitive function in APPswe/PS1dE9 mice Med Sci Monit (2018) 24, 2446-2455. PubMed Europe PubMed DOI PMC EPMC
Zhang,Z., Liang,W.G., Bailey,L.J., Tan,Y.Z., Wei,H., Wang,A., Farcasanu,M., Woods,V.A., McCord,L.A., Lee,D., Shang,W., Deprez-Poulain,R., Deprez,B., Liu,D.R., Koide,A., Koide,S., Kossiakoff,A.A., Li,S., Carragher,B., Potter,C.S. and Tang,W.J. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme elife (2018) 7 PubMed Europe PubMed DOI S

2017

Hahn,F., Schmalen,A., Setz,C., Friedrich,M., Schlosser,S., Kolle,J., Spranger,R., Rauch,P., Fraedrich,K., Reif,T., Karius-Fischer,J., Balasubramanyam,A., Henklein,P., Fossen,T. and Schubert,U. Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner PLoS ONE (2017) 12, e0174254-e0174254. PubMed Europe PubMed DOI
Jamal,S., Goyal,S., Shanker,A. and Grover,A. Machine learning and molecular dynamics based insights into mode of actions of insulin degrading enzyme modulators Comb Chem High Throughput Screen (2017) 20, 279-291. PubMed Europe PubMed
Kurochkin,I.V., Guarnera,E., Wong,J.H., Eisenhaber,F. and Berezovsky,I.N. Toward allosterically increased catalytic activity of insulin-degrading enzyme against amyloid peptides Biochemistry (2017) 56, 228-239. PubMed Europe PubMed DOI
Li,H., Wu,J., Zhu,L., Sha,L., Yang,S., Wei,J., Ji,L., Tang,X., Mao,K., Cao,L., Wei,N., Xie,W. and Yang,Z. Insulin degrading enzyme contributes to the pathology in a mixed model of type 2 diabetes and Alzheimer's disease Biosci Rep (2017) 38, BSR20170862-BSR20170862. PubMed Europe PubMed DOI
Song,E.S., Jang,H., Guo,H.F., Juliano,M.A., Juliano,L., Morris,A.J., Galperin,E., Rodgers,D.W. and Hersh,L.B. Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes Proc Natl Acad Sci U S A (2017) 114, E2826-E2835. PubMed Europe PubMed DOI
Tundo,G.R., Sbardella,D., Ciaccio,C., Grasso,G., Gioia,M., Coletta,A., Polticelli,F., Di Pierro,D., Milardi,D., van Endert,P., Marini,S. and Coletta,M. Multiple functions of insulin-degrading enzyme: a metabolic crosslight? Crit Rev Biochem Mol Biol (2017) 52, 554-582. PubMed Europe PubMed DOI

2016

Cai,P., Zhong,W., Jia,M., Yu,C., Peng,Y., Wang,Y., Wang,H., Zeng,C., Bai,Y. and Wang,X. The gene polymorphisms of insulin degrading enzyme (IDE) are associated with the risk of coronary heart disease in Chinese Han population Int J Clin Exp Pathol (2016) 9, 5544-5551. M
Grimm,M.O., Mett,J., Stahlmann,C.P., Haupenthal,V.J., Blumel,T., Stotzel,H., Grimm,H.S. and Hartmann,T. Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-beta by affecting insulin-degrading enzyme Biochem Cell Biol (2016) 94, 534-542. PubMed Europe PubMed DOI
Hogan,M.F., Meier,D.T., Zraika,S., Templin,A.T., Mellati,M., Hull,R.L., Leissring,M.A. and Kahn,S.E. Inhibition of insulin-degrading enzyme does not increase islet amyloid deposition in vitro Endocrinology (2016) 157, 3462-3468. PubMed Europe PubMed DOI I
Hubin,E., Cioffi,F., Rozenski,J., Van Nuland,N.A. and Broersen,K. Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation states Biochim Biophys Acta (2016) 1860, 1281-1290. PubMed Europe PubMed DOI P
Lukman,S. Novel druggable sites of insulin-degrading enzyme identified through applied structural bioinformatics analysis Procedia Comput Sci (2016) 80, 2292-2296. DOI I
Paul,T.J., Barman,A., Ozbil,M., Bora,R.P., Zhang,T., Sharma,G., Hoffmann,Z. and Prabhakar,R. Mechanisms of peptide hydrolysis by aspartyl and metalloproteases Phys Chem Chem Phys (2016) 18, 24790-24801. PubMed Europe PubMed DOI
Pivovarova,O., Hohn,A., Grune,T., Pfeiffer,A.F. and Rudovich,N. Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease? Ann Med (2016) 48, 614-624. PubMed Europe PubMed DOI T I
Son,S.M., Cha,M.Y., Choi,H., Kang,S., Choi,H., Lee,M.S., Park,S.A. and Mook-Jung,I. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease Autophagy (2016) 12, 784-800. PubMed Europe PubMed DOI
Tang,W.J. Targeting insulin-degrading enzyme to treat type 2 diabetes mellitus Trends Endocrinol Metab (2016) 27, 24-34. PubMed Europe PubMed DOI I
Tundo,G.R., Di Muzio,E., Ciaccio,C., Sbardella,D., Di Pierro,D., Polticelli,F., Coletta,M. and Marini,S. Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin FEBS J (2016) 283, 3755-3770. PubMed Europe PubMed DOI

2015

Abdul-Hay,S.O., Bannister,T.D., Wang,H., Cameron,M.D., Caulfield,T.R., Masson,A., Bertrand,J., Howard,E.A., McGuire,M.P., Crisafulli,U., Rosenberry,T.R., Topper,C.L., Thompson,C.R., Schurer,S.C., Madoux,F., Hodder,P. and Leissring,M.A. Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors ACS Chem Biol (2015) 10, 2716-2724. PubMed Europe PubMed DOI I
Charton,J., Gauriot,M., Totobenazara,J., Hennuyer,N., Dumont,J., Bosc,D., Marechal,X., Elbakali,J., Herledan,A., Wen,X., Ronco,C., Gras-Masse,H., Heninot,A., Pottiez,V., Landry,V., Staels,B., Liang,W.G., Leroux,F., Tang,W.J., Deprez,B. and Deprez-Poulain,R. Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme Eur J Med Chem (2015) 90C, 547-567. PubMed Europe PubMed DOI S I
Cheng,H., Wang,L., Shi,T., Shang,Y. and Jiang,L. Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis Int J Neurosci (2015) 125, 328-335. PubMed Europe PubMed DOI M
Del Campo,M., Stargardt,A., Veerhuis,R., Reits,E. and Teunissen,C.E. Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Abeta by insulin degrading enzyme (IDE) in Alzheimer's disease Neurosci Lett (2015) 589C, 47-51. PubMed Europe PubMed DOI
Deprez-Poulain,R., Hennuyer,N., Bosc,D., Liang,W.G., Enee,E., Marechal,X., Charton,J., Totobenazara,J., Berte,G., Jahklal,J., Verdelet,T., Dumont,J., Dassonneville,S., Woitrain,E., Gauriot,M., Paquet,C., Duplan,I., Hermant,P., Cantrelle,F.X., Sevin,E., Culot,M., Landry,V., Herledan,A., Piveteau,C., Lippens,G., Leroux,F., Tang,W.J., van Endert,P., Staels,B. and Deprez,B. Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice Nat Commun (2015) 6, 8250-8250. PubMed Europe PubMed DOI PMC EPMC I
Durham,T.B., Toth,J.L., Klimkowski,V.J., Cao,J.X., Siesky,A.M., Alexander-Chacko,J., Wu,G.Y., Dixon,J.T., McGee,J.E., Wang,Y., Guo,S.Y., Cavitt,R.N., Schindler,J., Thibodeaux,S.J., Calvert,N.A., Coghlan,M.J., Sindelar,D.K., Christe,M., Kiselyov,V.V., Michael,M.D. and Sloop,K.W. Dual exosite-binding inhibitors of insulin-degrading enzyme challenge its role as the primary mediator of insulin clearance in vivo J Biol Chem (2015) 290, 20044-20059. PubMed Europe PubMed DOI K I
Grasso,G., Satriano,C. and Milardi,D. A neglected modulator of insulin-degrading enzyme activity and conformation: the pH Biophys Chem (2015) 203-204C, 33-40. PubMed Europe PubMed DOI
Grasso,G., Lanza,V., Malgieri,G., Fattorusso,R., Pietropaolo,A., Rizzarelli,E. and Milardi,D. The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin Chem Commun (Camb) (2015) 51, 15724-15727. PubMed Europe PubMed DOI
Grune,T. Insulin-degrading enzyme: Is it suitable for diabetes treatment? Cell Cycle (2015) 14, 2553- PubMed Europe PubMed DOI
Gutierrez-Hermosillo,H., Diaz De Leon-Gonzalez,E., Palacios-Corona,R., Cedillo-Rodriguez,J.A., Camacho-Luis,A., Reyes-Romero,M.A., Medina-Chavez,J.H. and Blandon,P.A. C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study Med Clin (Barc) (2015) 144, 151-155. PubMed Europe PubMed DOI M
Jha,N.K., Jha,S.K., Kumar,D., Kejriwal,N., Sharma,R., Ambasta,R.K. and Kumar,P. Impact of insulin degrading enzyme and neprilysin in Alzheimer's disease biology: characterization of putative cognates for therapeutic applications J Alzheimers Dis (2015) 48, 891-917. PubMed Europe PubMed DOI
Liang,W.G., Ren,M., Zhao,F. and Tang,W.J. Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme J Mol Biol (2015) 427, 1345-1358. PubMed Europe PubMed DOI
Sbardella,D., Tundo,G.R., Sciandra,F., Bozzi,M., Gioia,M., Ciaccio,C., Tarantino,U., Brancaccio,A., Coletta,M. and Marini,S. Proteasome activity is affected by fluctuations in insulin-degrading enzyme distribution PLoS ONE (2015) 10, e0132455-e0132455. PubMed Europe PubMed DOI PMC EPMC
Sharma,S.K., Chorell,E., Steneberg,P., Vernersson-Lindahl,E., Edlund,H. and Wittung-Stafshede,P. Insulin-degrading enzyme prevents alpha-synuclein fibril formation in a nonproteolytical manner Sci Rep (2015) 5, 12531-12531. PubMed Europe PubMed DOI PMC EPMC
Sharma,S.K., Chorell,E. and Wittung-Stafshede,P. Insulin-degrading enzyme is activated by the C-terminus of alpha-synuclein Biochem Biophys Res Commun (2015) 466, 192-195. PubMed Europe PubMed DOI
Son,S.M., Kang,S., Choi,H. and Mook-Jung,I. Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway Mol Neurodegener (2015) 10, 56-56. PubMed Europe PubMed DOI PMC EPMC
Song,E.S., Ozbil,M., Zhang,T., Sheetz,M., Lee,D., Tran,D., Li,S., Prabhakar,R., Hersh,L.B. and Rodgers,D.W. An Extended Polyanion Activation Surface in Insulin Degrading Enzyme PLoS ONE (2015) 10, e0133114-e0133114. PubMed Europe PubMed DOI PMC EPMC
Tundo,G.R., Sbardella,D., De Pascali,S.A., Ciaccio,C., Coletta,M., Fanizzi,F.P. and Marini,S. Novel platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells J Biol Inorg Chem (2015) 20, 101-108. PubMed Europe PubMed DOI I
Vingtdeux,V., Chandakkar,P., Zhao,H., Blanc,L., Ruiz,S. and Marambaud,P. CALHM1 ion channel elicits amyloid-beta clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain J Cell Sci (2015) 128, 2330-2338. PubMed Europe PubMed DOI
Wang,S., He,F. and Wang,Y. Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease J Geriatr Psychiatry Neurol (2015) 28, 94-98. PubMed Europe PubMed DOI M

2014

Therapy: Targeting insulin-degrading enzyme in diabetes mellitus Nat Rev Endocrinol (2014) 10, 446-446. DOI I
Bellia,F. and Grasso,G. The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme J Mass Spectrom (2014) 49, 274-279. PubMed Europe PubMed DOI
Charton,J., Gauriot,M., Guo,Q., Hennuyer,N., Marechal,X., Dumont,J., Hamdane,M., Pottiez,V., Landry,V., Sperandio,O., Flipo,M., Buee,L., Staels,B., Leroux,F., Tang,W.J., Deprez,B. and Deprez-Poulain,R. Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis Eur J Med Chem (2014) 79, 184-193. PubMed Europe PubMed DOI I
Costes,S. and Butler,P.C. Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes? Cell Metab (2014) 20, 201-203. PubMed Europe PubMed DOI
Culina,S., Mauvais,F.X., Hsu,H.T., Burgevin,A., Guenette,S., Moser,A. and van Endert,P. No major role for insulin-degrading enzyme in antigen presentation by MHC molecules PLoS ONE (2014) 9, e88365-e88365. PubMed Europe PubMed DOI PMC EPMC
da Cruz,C.H. and Seabra,G. Molecular dynamics simulations reveal a novel mechanism for ATP inhibition of insulin degrading enzyme J Chem Inf Model (2014) 54, 1380-1390. PubMed Europe PubMed DOI
Galagovsky,D., Katz,M.J., Acevedo,J.M., Sorianello,E., Glavic,A. and Wappner,P. The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner Mol Biol Cell (2014) 25, 916-924. PubMed Europe PubMed DOI
Grasso,G., Mielczarek,P., Niedziolka,M. and Silberring,J. Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme Int J Mol Sci (2014) 15, 16787-16799. PubMed Europe PubMed DOI P
Haque,R. and Nazir,A. Insulin-degrading enzyme: a link between Alzheimer's and type 2 diabetes mellitus CNS Neurol Disord Drug Targets (2014) 13, 259-264. PubMed Europe PubMed
Ito,S., Ohtsuki,S., Murata,S., Katsukura,Y., Suzuki,H., Funaki,M., Tachikawa,M. and Terasaki,T. Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-beta peptide in mouse brain capillary endothelial cells J Alzheimers Dis (2014) 38, 185-200. PubMed Europe PubMed DOI
Kurklinsky,S., Abdul-Hay,S.O., McGuire,M.P., Howard,E.A., Knight,J. and Leissring,M.A. The blood glucose-lowering effect of racecadotril is not attributable to inhibition of insulin-degrading enzyme Horm Metab Res (2014) 46, 73-74. PubMed Europe PubMed DOI I
Maianti,J.P., McFedries,A., Foda,Z.H., Kleiner,R.E., Du,X.Q., Leissring,M.A., Tang,W.J., Charron,M.J., Seeliger,M.A., Saghatelian,A. and Liu,D.R. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones Nature (2014) 511, 94-98. PubMed Europe PubMed DOI S I
Qiu,W.Q. and Zhu,H. Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease? Front Aging Neurosci (2014) 6, 186-186. PubMed Europe PubMed DOI PMC EPMC
Shaik,N.A., Kaleemuddin,M., Banaganapalli,B., Khan,F., Shaik,N.S., Ajabnoor,G., Al-Harthi,S.E., Bondagji,N., Al-Aama,J.Y. and Elango,R. Structural and functional characterization of pathogenic non-synonymous genetic mutations of human insulin-degrading enzyme by in silico methods CNS Neurol Disord Drug Targets (2014) 13, 517-532. PubMed Europe PubMed DOI M

2013

Abdul-Hay,S.O., Lane,A.L., Caulfield,T.R., Claussin,C., Bertrand,J., Masson,A., Choudhry,S., Fauq,A.H., Maharvi,G.M. and Leissring,M.A. Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity J Med Chem (2013) 56, 2246-2255. PubMed Europe PubMed DOI I
Bellia,F., Pietropaolo,A. and Grasso,G. Formation of insulin fragments by insulin-degrading enzyme: the role of zinc(II) and cystine bridges J Mass Spectrom (2013) 48, 135-140. PubMed Europe PubMed DOI P
Caravaggio,J.W., Hasu,M., Maclaren,R., Thabet,M., Raizman,J.E., Veinot,J.P., Marcel,Y.L., Milne,R.W. and Whitman,S.C. Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice Cardiovasc Pathol (2013) 22, 458-464. PubMed Europe PubMed DOI K
Carty,N., Nash,K.R., Brownlow,M., Cruite,D., Wilcock,D., Selenica,M.L., Lee,D.C., Gordon,M.N. and Morgan,D. Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice PLoS ONE (2013) 8, e59626-e59626. PubMed Europe PubMed DOI PMC EPMC U
de Tullio,M.B., Castelletto,V., Hamley,I.W., Martino Adami,P.V., Morelli,L. and Castano,E.M. Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic abeta peptide aggregates PLoS ONE (2013) 8, e59113-e59113. PubMed Europe PubMed DOI PMC EPMC
Leal,M.C., Magnani,N., Villordo,S., Buslje,C.M., Evelson,P., Castano,E.M. and Morelli,L. Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid beta (Abeta) peptide catabolism and functionality J Biol Chem (2013) 288, 12920-12931. PubMed Europe PubMed DOI
Lifshitz,V., Benromano,T., Weiss,R., Blanga-Kanfi,S. and Frenkel,D. Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model Brain Behav Immun (2013) 30, 143-149. PubMed Europe PubMed DOI K
McCord,L.A., Liang,W.G., Dowdell,E., Kalas,V., Hoey,R.J., Koide,A., Koide,S. and Tang,W.J. Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme Proc Natl Acad Sci U S A (2013) 110, 13827-13832. PubMed Europe PubMed DOI S
Tundo,G.R., Sbardella,D., Ciaccio,C., Bianculli,A., Orlandi,A., Desimio,M.G., Arcuri,G., Coletta,M. and Marini,S. Insulin-degrading enzyme (IDE): a novel heat shock-like protein J Biol Chem (2013) 288, 2281-2289. PubMed Europe PubMed DOI
Zhang,L., Ding,Q., Wang,P. and Wang,Z. An upstream promoter element blocks the reverse transcription of the mouse insulin-degrading enzyme gene Biochem Biophys Res Commun (2013) 430, 26-31. PubMed Europe PubMed DOI
Zhang,L., Wang,P., Ding,Q. and Wang,Z. Transcriptional directionality of the human insulin-degrading enzyme promoter Mol Cell Biochem (2013) 382, 237-242. PubMed Europe PubMed DOI
Zhang,Y., Wang,B., Wan,H., Zhou,Q. and Li,T. Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease Neurosci Lett (2013) 541, 132-137. PubMed Europe PubMed DOI M

2012

Cakir,B., Dagliyan,O., Dagyildiz,E., Baris,I., Kavakli,I.H., Kizilel,S. and Turkay,M. Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme PLoS ONE (2012) 7, e31787-e31787. PubMed Europe PubMed DOI PMC EPMC
Cui,P.J., Cao,L., Wang,Y., Deng,Y.L., Xu,W., Wang,G., Zhang,Y., Zheng,L., Fei,Q.Z., Zhang,T. and Chen,S.D. The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population J Clin Neurosci (2012) 19, 745-749. PubMed Europe PubMed DOI M
Grasso,G., Salomone,F., Tundo,G.R., Pappalardo,G., Ciaccio,C., Spoto,G., Pietropaolo,A., Coletta,M. and Rizzarelli,E. Metal ions affect insulin-degrading enzyme activity J Inorg Biochem (2012) 117, 351-358. PubMed Europe PubMed DOI
Kukday,S.S., Manandhar,S.P., Ludley,M.C., Burriss,M.E., Alper,B.J. and Schmidt,W.K. Cell-permeable, small-molecule activators of the insulin-degrading enzyme J Biomol Screen (2012) 17, 1348-1361. PubMed Europe PubMed DOI
Kummer,M.P., Hulsmann,C., Hermes,M., Axt,D. and Heneka,M.T. Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice J Neuroimmune Pharmacol (2012) 7, 165-172. PubMed Europe PubMed DOI
Leal,M.C., Surace,E.I., Holgado,M.P., Ferrari,C.C., Tarelli,R., Pitossi,F., Wisniewski,T., Castano,E.M. and Morelli,L. Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Abeta metabolism Biochim Biophys Acta (2012) 1823, 227-235. PubMed Europe PubMed DOI
Leal,M.C. and Morelli,L. Insulysin [ISSN:978-0-12-407744-7] (2012) 3, 1415-1420. DOI
Noinaj,N., Song,E.S., Bhasin,S., Alper,B.J., Schmidt,W.K., Hersh,L.B. and Rodgers,D.W. Anion activation site of insulin-degrading enzyme J Biol Chem (2012) 287, 48-57. PubMed Europe PubMed DOI
Song,E.S., Melikishvili,M., Fried,M.G., Juliano,M.A., Juliano,L., Rodgers,D.W. and Hersh,L.B. Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation PLoS ONE (2012) 7, e46790-e46790. PubMed Europe PubMed DOI PMC EPMC

2011

Abdul-Hay,S.O., Kang,D., McBride,M., Li,L., Zhao,J. and Leissring,M.A. Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin tolerance PLoS ONE (2011) 6, e20818-e20818. PubMed Europe PubMed DOI PMC EPMC K
Bartl,J., Scholz,C.J., Hinterberger,M., Jungwirth,S., Wichart,I., Rainer,M.K., Kneitz,S., Danielczyk,W., Tragl,K.H., Fischer,P., Riederer,P. and Grunblatt,E. Disorder-specific effects of polymorphisms at opposing ends of the insulin degrading enzyme gene BMC Med Genet (2011) 12, 151-151. PubMed Europe PubMed DOI
Belbin,O., Crump,M., Bisceglio,G.D., Carrasquillo,M.M., Morgan,K. and Younkin,S.G. Multiple insulin degrading enzyme variants alter in vitro reporter gene expression PLoS ONE (2011) 6, e21429-e21429. PubMed Europe PubMed DOI PMC EPMC M
Cordes,C.M., Bennett,R.G., Siford,G.L. and Hamel,F.G. Redox regulation of insulin degradation by insulin-degrading enzyme PLoS ONE (2011) 6, e18138-e18138. PubMed Europe PubMed DOI PMC EPMC
Glebov,K., Schutze,S. and Walter,J. Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme J Biol Chem (2011) 286, 22711-22715. PubMed Europe PubMed DOI
Hyun,J. and Hashimoto,C. Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila Fly (Austin) (2011) 5, 53-57. PubMed Europe PubMed DOI
Kim,M.S., Goo,J.S., Kim,J.E., Nam,S.H., Choi,S.I., Lee,H.R., Hwang,I.S., Shim,S.B., Jee,S.W., Lee,S.H., Bae,C.J., Cho,J.S., Cho,J.Y. and Hwang,D.Y. Overexpression of insulin degrading enzyme could greatly contribute to insulin down-regulation induced by short-term swimming exercise Lab Anim Res (2011) 27, 29-36. PubMed Europe PubMed DOI PMC EPMC
Lee,J.P., Cheng,K.C., Chung,H.H., Wu,H.T., Chen,C.T. and Cheng,J.T. Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats Horm Metab Res (2011) 43, 489-493. PubMed Europe PubMed DOI I
Noinaj,N., Bhasin,S.K., Song,E.S., Scoggin,K.E., Juliano,M.A., Juliano,L., Hersh,L.B. and Rodgers,D.W. Identification of the allosteric regulatory site of insulysin PLoS ONE (2011) 6, e20864-e20864. PubMed Europe PubMed DOI PMC EPMC S
Ralat,L.A., Guo,Q., Ren,M., Funke,T., Dickey,D.M., Potter,L.R. and Tang,W.J. Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response J Biol Chem (2011) 286, 4670-4679. PubMed Europe PubMed DOI
Ralat,L.A., Kalas,V., Zheng,Z., Goldman,R.D., Sosnick,T.R. and Tang,W.J. Ubiquitin is a novel substrate for human insulin-degrading enzyme J Mol Biol (2011) 406, 454-466. PubMed Europe PubMed DOI P
Song,E.S., Rodgers,D.W. and Hersh,L.B. Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism J Biol Chem (2011) 286, 13852-13858. PubMed Europe PubMed DOI
Zhao,L., Yao,J., Mao,Z., Chen,S., Wang,Y. and Brinton,R.D. 17beta-Estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention Neurobiol Aging (2011) 32, 1949-1963. PubMed Europe PubMed DOI

2010

Bannister,T.D., Wang,H., Abdul-Hay,S.O., Masson,A., Madoux,F., Ferguson,J., Mercer,B.A., Schurer,S., Zuhl,A., Cravatt,B.F., Leissring,M.A. and Hodder,P. ML345: A small-molecule inhibitor of the insulin-degrading enzyme (IDE) (2010) PubMed Europe PubMed I
Bora,R.P., Ozbil,M. and Prabhakar,R. Elucidation of insulin degrading enzyme catalyzed site specific hydrolytic cleavage of amyloid beta peptide: a comparative density functional theory study J Biol Inorg Chem (2010) 15, 485-495. PubMed Europe PubMed DOI P
Bora,R.P. and Prabhakar,R. Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study Biochemistry (2010) 49, 3947-3956. PubMed Europe PubMed DOI
Bulloj,A., Leal,M.C., Xu,H., Castano,E.M. and Morelli,L. Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease J Alzheimers Dis (2010) 19, 79-95. PubMed Europe PubMed DOI
Carpenter,J.E., Jackson,W., de Souza,G.A., Haarr,L. and Grose,C. Insulin-degrading enzyme binds to the nonglycosylated precursor of varicella-zoster virus gE protein found in the endoplasmic reticulum J Virol (2010) 84, 847-855. PubMed Europe PubMed DOI
Carrasquillo,M.M., Belbin,O., Zou,F., Allen,M., Ertekin-Taner,N., Ansari,M., Wilcox,S.L., Kashino,M.R., Ma,L., Younkin,L.H., Younkin,S.G., Younkin,C.S., Dincman,T.A., Howard,M.E., Howell,C.C., Stanton,C.M., Watson,C.M., Crump,M., Vitart,V., Hayward,C., Hastie,N.D., Rudan,I., Campbell,H., Polasek,O., Brown,K., Passmore,P., Craig,D., McGuinness,B., Todd,S., Kehoe,P.G., Mann,D.M., Smith,A.D., Beaumont,H., Warden,D., Holmes,C., Heun,R., Kolsch,H., Kalsheker,N., Pankratz,V.S., Dickson,D.W., Graff-Radford,N.R., Petersen,R.C., Wright,A.F., Younkin,S.G. and Morgan,K. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease PLoS ONE (2010) 5, e8764-e8764. PubMed Europe PubMed DOI PMC EPMC M
Chen,P.T., Liao,T.Y., Hu,C.J., Wu,S.T., Wang,S.S. and Chen,R.P. A highly sensitive peptide substrate for detecting two Abeta-degrading enzymes: neprilysin and insulin-degrading enzyme J Neurosci Methods (2010) 190, 57-62. PubMed Europe PubMed DOI A
Du,J., Zhang,L., Liu,S. and Wang,Z. Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons Pharmazie (2010) 65, 231-232. PubMed Europe PubMed DOI
Guo,Q., Manolopoulou,M., Bian,Y., Schilling,A.B. and Tang,W.J. Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme J Mol Biol (2010) 395, 430-443. PubMed Europe PubMed DOI P
Leissring,M.A., Malito,E., Hedouin,S., Reinstatler,L., Sahara,T., Abdul-Hay,S.O., Choudhry,S., Maharvi,G.M., Fauq,A.H., Huzarska,M., May,P.S., Choi,S., Logan,T.P., Turk,B.E., Cantley,L.C., Manolopoulou,M., Tang,W.J., Stein,R.L., Cuny,G.D. and Selkoe,D.J. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin PLoS ONE (2010) 5, e10504-e10504. PubMed Europe PubMed DOI PMC EPMC S I
Parmentier,N., Stroobant,V., Colau,D., de Diesbach,P., Morel,S., Chapiro,J., van Endert,P. and Van den Eynde,B.J. Production of an antigenic peptide by insulin-degrading enzyme Nat Immunol (2010) 11, 449-454. PubMed Europe PubMed DOI
Ren,M., Guo,Q., Guo,L., Lenz,M., Qian,F., Koenen,R.R., Xu,H., Schilling,A.B., Weber,C., Ye,R.D., Dinner,A.R. and Tang,W.J. Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme EMBO J (2010) 29, 3952-3966. PubMed Europe PubMed DOI
Song,E.S., Rodgers,D.W. and Hersh,L.B. A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties PLoS ONE (2010) 5, e9719-e9719. PubMed Europe PubMed DOI PMC EPMC
Tamboli,I.Y., Barth,E., Christian,L., Siepmann,M., Kumar,S., Singh,S., Tolksdorf,K., Heneka,M.T., Lutjohann,D., Wunderlich,P. and Walter,J. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion J Biol Chem (2010) 285, 37405-37414. PubMed Europe PubMed DOI
Tsuda,M., Kobayashi,T., Matsuo,T. and Aigaki,T. Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila FEBS Lett (2010) 584, 2916-2920. PubMed Europe PubMed DOI K
Zhang,W.J., Luo,X. and Guo,Z.Y. In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme Protein J (2010) 29, 93-98. PubMed Europe PubMed DOI P

2009

Ali,M.A., Li,Q., Fischer,E.R. and Cohen,J.I. The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection Virology (2009) 386, 270-279. PubMed Europe PubMed DOI
Amata,O., Marino,T., Russo,N. and Toscano,M. Human insulin-degrading enzyme working mechanism J Am Chem Soc (2009) 131, 14804-14811. PubMed Europe PubMed DOI
Bennett,R.G., Heimann,D.G. and Hamel,F.G. Degradation of relaxin family peptides by insulin-degrading enzyme Ann N Y Acad Sci (2009) 1160, 38-41. PubMed Europe PubMed DOI PMC EPMC
Cabrol,C., Huzarska,M.A., Dinolfo,C., Rodriguez,M.C., Reinstatler,L., Ni,J., Yeh,L.A., Cuny,G.D., Stein,R.L., Selkoe,D.J. and Leissring,M.A. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening PLoS ONE (2009) 4, e5274-e5274. PubMed Europe PubMed DOI PMC EPMC
Chou,Y.H., Kuo,W.L., Rosner,M.R., Tang,W.J. and Goldman,R.D. Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme FASEB J (2009) 23, 3734-3742. PubMed Europe PubMed DOI
Ciaccio,C., Tundo,G.R., Grasso,G., Spoto,G., Marasco,D., Ruvo,M., Gioia,M., Rizzarelli,E. and Coletta,M. Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity J Mol Biol (2009) 385, 1556-1567. PubMed Europe PubMed DOI P
Cordes,C.M., Bennett,R.G., Siford,G.L. and Hamel,F.G. Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation Biochem Pharmacol (2009) 77, 1064-1073. PubMed Europe PubMed DOI I
Delledonne,A., Kouri,N., Reinstatler,L., Sahara,T., Li,L., Zhao,J., Dickson,D.W., Ertekin-Taner,N. and Leissring,M.A. Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme Mol Neurodegener (2009) 4, 39-39. PubMed Europe PubMed DOI PMC EPMC
Du,J., Zhang,L., Liu,S., Zhang,C., Huang,X., Li,J., Zhao,N. and Wang,Z. PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons Biochem Biophys Res Commun (2009) 383, 485-490. PubMed Europe PubMed DOI
Fawcett,J. and Duckworth,W.C. Hyperglycaemia and hyperinsulinaemia: is insulin-degrading enzyme the missing link? Diabetologia (2009) 52, 1457-1460. PubMed Europe PubMed DOI
Fernandez-Gamba,A., Leal,M.C., Morelli,L. and Castano,E.M. Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease Curr Pharm Des (2009) 15, 3644-3655. PubMed Europe PubMed DOI V
Grasso,G., Bush,A.I., D'Agata,R., Rizzarelli,E. and Spoto,G. Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme Eur Biophys J (2009) 38, 407-414. PubMed Europe PubMed DOI
Grasso,G., Rizzarelli,E. and Spoto,G. The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study J Mass Spectrom (2009) 44, 735-741. PubMed Europe PubMed DOI P
Hulse,R.E., Ralat,L.A. and Wei-Jen,T. Structure, function, and regulation of insulin-degrading enzyme Vitam Horm (2009) 80, 635-648. PubMed Europe PubMed DOI V
Lu,X., Huang,Y., Liu,Y., Wu,X. and Shi,X. Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders Metabolism (2009) 58, 1465-1469. PubMed Europe PubMed DOI M
Manolopoulou,M., Guo,Q., Malito,E., Schilling,A.B. and Tang,W.J. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme J Biol Chem (2009) 284, 14177-14188. PubMed Europe PubMed DOI PMC EPMC
Miners,J.S., Baig,S., Tayler,H., Kehoe,P.G. and Love,S. Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity J Neuropathol Exp Neurol (2009) 68, 902-914. PubMed Europe PubMed DOI
Ralat,L.A., Ren,M., Schilling,A.B. and Tang,W.J. Protective role of CYS-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation J Biol Chem (2009) 284, 34005-34018. PubMed Europe PubMed DOI
Rudovich,N., Pivovarova,O., Fisher,E., Fischer-Rosinsky,A., Spranger,J., Mohlig,M., Schulze,M.B., Boeing,H. and Pfeiffer,A.F. Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes J Mol Med (2009) 87, 1145-1151. PubMed Europe PubMed DOI M
Slominsky,P.A., Pivovarova,O.V., Shadrina,M.I., Artem'Eva,A.V., Pfaipffer,F.G., Rudovich,N.N., Agadghanyan,S.E., Pronin,V.S. and Limborska,S.A. Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population Russ J Genet (2009) 45, 113-117. DOI M
Vepsalainen,S., Helisalmi,S., Mannermaa,A., Pirttila,T., Soininen,H. and Hiltunen,M. Combined risk effects of IDE and NEP gene variants on Alzheimer disease J Neurol Neurosurg Psychiatry (2009) 80, 1268-1270. PubMed Europe PubMed DOI M
Zhao,J., Li,L. and Leissring,M.A. Insulin-degrading enzyme is exported via an unconventional protein secretion pathway Mol Neurodegener (2009) 4, 4-4. PubMed Europe PubMed DOI PMC EPMC
Zuo,X. and Jia,J. Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease Brain Res (2009) 1249, 1-8. PubMed Europe PubMed DOI M

2008

Bernstein,H.G., Lendeckel,U., Bukowska,A., Ansorge,S., Ernst,T., Stauch,R., Trubner,K., Steiner,J., Dobrowolny,H. and Bogerts,B. Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary J Chem Neuroanat (2008) 35, 216-224. PubMed Europe PubMed DOI
Bulloj,A., Leal,M.C., Surace,E.I., Zhang,X., Xu,H., Ledesma,M.D., Castano,E.M. and Morelli,L. Detergent resistant membrane-associated IDE in brain tissue and cultured cells: relevance to Abeta and insulin degradation Mol Neurodegener (2008) 3, 22-22. PubMed Europe PubMed DOI PMC EPMC
de Tullio,M.B., Morelli,L. and Castano,E.M. The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective Prion (2008) 2, 51-56. PubMed Europe PubMed PMC EPMC
Epting,C.L., King,F.W., Pedersen,A., Zaman,J., Ritner,C. and Bernstein,H.S. Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts J Cell Physiol (2008) 217, 250-260. PubMed Europe PubMed DOI PMC EPMC
Grasso,G., Rizzarelli,E. and Spoto,G. How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin Biochim Biophys Acta (2008) 1784, 1122-1126. PubMed Europe PubMed DOI
Hong,M.G., Reynolds,C., Gatz,M., Johansson,B., Palmer,J.C., Gu,H.F., Blennow,K., Kehoe,P.G., de Faire,U., Pedersen,N.L. and Prince,J.A. Evidence that the gene encoding insulin degrading enzyme influences human lifespan Hum Mol Genet (2008) 17, 2370-2378. PubMed Europe PubMed DOI PMC EPMC M
Kwak,S.H., Cho,Y.M., Moon,M.K., Kim,J.H., Park,B.L., Cheong,H.S., Shin,H.D., Jang,H.C., Kim,S.Y., Lee,H.K. and Park,K.S. Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population Diabetes Res Clin Pract (2008) 79, 284-290. PubMed Europe PubMed DOI M
Llovera,R.E., de Tullio,M., Alonso,L.G., Leissring,M.A., Kaufman,S.B., Roher,A.E., de Prat Gay,G., Morelli,L. and Castano,E.M. The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis J Biol Chem (2008) 283, 17039-17048. PubMed Europe PubMed DOI
Malito,E., Hulse,R.E. and Tang,W.J. Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin Cell Mol Life Sci (2008) 65, 2574-2585. PubMed Europe PubMed DOI PMC EPMC
Malito,E., Ralat,L.A., Manolopoulou,M., Tsay,J.L., Wadlington,N.L. and Tang,W.J. Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme Biochemistry (2008) 47, 12822-12834. PubMed Europe PubMed DOI PMC EPMC S
Miners,J.S., Kehoe,P.G. and Love,S. Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates J Neurosci Methods (2008) 169, 177-181. PubMed Europe PubMed DOI A
Neant-Fery,M., Garcia-Ordonez,R.D., Logan,T.P., Selkoe,D.J., Li,L., Reinstatler,L. and Leissring,M.A. Molecular basis for the thiol sensitivity of insulin-degrading enzyme Proc Natl Acad Sci U S A (2008) 105, 9582-9587. PubMed Europe PubMed DOI PMC EPMC
Wang,K., You,L., Shi,Y., Wang,L., Zhang,M. and Chen,Z.J. Association of genetic variants of insulin degrading enzyme with metabolic features in women with polycystic ovary syndrome Fertil Steril (2008) 90, 378-384. PubMed Europe PubMed DOI M
Weirich,G., Mengele,K., Yfanti,C., Gkazepis,A., Hellmann,D., Welk,A., Giersig,C., Kuo,W.L., Rosner,M.R., Tang,W.J. and Schmitt,M. Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines Biol Chem (2008) 389, 1441-1445. PubMed Europe PubMed DOI
Yfanti,C., Mengele,K., Gkazepis,A., Weirich,G., Giersig,C., Kuo,W.L., Tang,W.J., Rosner,M. and Schmitt,M. Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues Int J Mol Med (2008) 22, 421-431. PubMed Europe PubMed DOI

2007

Del Carmen Camberos,M. and Cresto,J.C. Insulin-degrading enzyme hydrolyzes ATP Exp Biol Med (Maywood) (2007) 232, 281-292. PubMed Europe PubMed
Fawcett,J., Permana,P.A., Levy,J.L. and Duckworth,W.C. Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing Arch Biochem Biophys (2007) 468, 128-133. PubMed Europe PubMed DOI
Grasso,G., Rizzarelli,E. and Spoto,G. AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin J Mass Spectrom (2007) 42, 1590-1598. PubMed Europe PubMed DOI P
Im,H., Manolopoulou,M., Malito,E., Shen,Y., Zhao,J., Neant-Fery,M., Sun,C.Y., Meredith,S.C., Sisodia,S.S., Leissring,M.A. and Tang,W.J. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE J Biol Chem (2007) 282, 25453-25463. PubMed Europe PubMed DOI S
Kim,M., Hersh,L.B., Leissring,M.A., Ingelsson,M., Matsui,T., Farris,W., Lu,A., Hyman,B.T., Selkoe,D.J., Bertram,L. and Tanzi,R.E. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families J Biol Chem (2007) 282, 7825-7832. PubMed Europe PubMed DOI
Li,Q., Krogmann,T., Ali,M.A., Tang,W.J. and Cohen,J.I. The amino terminus of Varicella-Zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor J Virol (2007) 81, 8525-8532. PubMed Europe PubMed DOI PMC EPMC
Radulescu,R.T., Hufnagel,C., Luppa,P., Hellebrand,H., Kuo,W.L., Rosner,M.R., Harbeck,N., Giersig,C., Meindl,A., Schmitt,M. and Weirich,G. Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels Int J Oncol (2007) 30, 73-80. PubMed Europe PubMed
Vepsalainen,S., Parkinson,M., Helisalmi,S., Mannermaa,A., Soininen,H., Tanzi,R.E., Bertram,L. and Hiltunen,M. Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population J Med Genet (2007) 44, 606-608. PubMed Europe PubMed DOI
Zhao,Z., Xiang,Z., Haroutunian,V., Buxbaum,J.D., Stetka,B. and Pasinetti,G.M. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease Neurobiol Aging (2007) 28, 824-830. PubMed Europe PubMed DOI

2006

Florez,J.C., Wiltshire,S., Agapakis,C.M., Burtt,N.P., de Bakker,P.I., Almgren,P., Bengtsson Bostrom,K., Tuomi,T., Gaudet,D., Daly,M.J., Hirschhorn,J.N., McCarthy,M.I., Altshuler,D. and Groop,L. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with Type 2 diabetes in 4,206 people Diabetes (2006) 55, 128-135. PubMed Europe PubMed DOI M
[YEAR:4-9-2006]Hersh,L.B. The insulysin (insulin degrading enzyme) enigma Cell Mol Life Sci (4-9-2006) 63, 2432-2434. PubMed Europe PubMed DOI V
[YEAR:19-10-2006]Leissring,M.A. and Selkoe,D.J. Structural biology: enzyme target to latch on to Nature (19-10-2006) 443, 761-762. PubMed Europe PubMed DOI
[YEAR:22-3-2006]Li,P., Kuo,W.L., Yousef,M., Rosner,M.R. and Tang,W.J. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition Biochem Biophys Res Commun (22-3-2006) 343, 1032-1037. PubMed Europe PubMed DOI
Li,Q., Ali,M.A. and Cohen,J.I. Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread Cell (2006) 127, 305-316. PubMed Europe PubMed DOI
[YEAR:1-3-2006]Lynch,J.A., George,A.M., Eisenhauer,P.B., Conn,K., Gao,W., Carreras,I., Wells,J.M., McKee,A., Ullman,M.D. and Fine,R.E. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures J Neurosci Res (1-3-2006) 83, 1262-1270. PubMed Europe PubMed DOI
Marlowe,L., Peila,R., Benke,K.S., Hardy,J., White,L.R., Launer,L.J. and Myers,A. Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk Neurodegener Dis (2006) 3, 320-326. PubMed Europe PubMed DOI M
[YEAR:14-8-2006]Ozturk,A., DeKosky,S.T. and Kamboh,M.I. Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease Neurosci Lett (14-8-2006) 406, 265-269. PubMed Europe PubMed DOI M
Qiu,W.Q. and Folstein,M.F. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis Neurobiol Aging (2006) 27, 190-198. PubMed Europe PubMed DOI
[YEAR:19-10-2006]Shen,Y., Joachimiak,A., Rosner,M.R. and Tang,W.J. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism Nature (19-10-2006) 443, 870-874. PubMed Europe PubMed DOI S
[YEAR:19-12-2006]Song,E.S., Cady,C., Fried,M.G. and Hersh,L.B. Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation Biochemistry (19-12-2006) 45, 15085-15091. PubMed Europe PubMed DOI PMC EPMC
[YEAR:6-5-2006]Yao,H. and Hersh,L.B. Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin Arch Biochem Biophys (6-5-2006) 451, 175-181. PubMed Europe PubMed DOI

2005

[YEAR:3-5-2005]Farris,W., Leissring,M.A., Hemming,M.L., Chang,A.Y. and Selkoe,D.J. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein Biochemistry (3-5-2005) 44, 6513-6525. PubMed Europe PubMed DOI R
[YEAR:27-4-2005]Feuk,L., McCarthy,S., Andersson,B., Prince,J.A. and Brookes,A.J. Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease Am J Med Genet B Neuropsychiatr Genet (27-4-2005) 136B, 69-71. PubMed Europe PubMed DOI
Hwang,D.Y., Cho,J.S., Kim,C.K., Shim,S.B., Jee,S.W., Lee,S.H., Seo,S.J., Cho,J.Y., Lee,S.H. and Kim,Y.K. Aging-related correlation of insulin-degrading enzyme with gamma-secretase-generated products involving insulin and glucose levels in transgenic mice Neurochem Res (2005) 30, 1171-1177. PubMed Europe PubMed DOI
[YEAR:8-6-2005]Kim,S., Lapham,A.N., Freedman,C.G., Reed,T.L. and Schmidt,W.K. Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme J Biol Chem (8-6-2005) 280, 27481-27490. PubMed Europe PubMed DOI E
[YEAR:8-7-2005]Morelli,L., Llovera,R.E., Alonso,L.G., Frangione,B., de Prat-Gay,G., Ghiso,J. and Castano,E.M. Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia Biochem Biophys Res Commun (8-7-2005) 332, 808-816. PubMed Europe PubMed DOI
[YEAR:27-4-2005]Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T., Holmans,P., Hamshere,M., Turic,D., Jehu,L., Hollingworth,P., Moore,P., Bryden,L., Myers,A., Doil,L.M., Tacey,K.M., Gibson,A.M., McKeith,I.G., Perry,R.H., Morris,C.M., Thal,L., Morris,J.C., O'Donovan,M.C., Lovestone,S., Grupe,A., Hardy,J., Owen,M.J., Williams,J. and Goate,A. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme Am J Med Genet B Neuropsychiatr Genet (27-4-2005) 136B, 62-68. PubMed Europe PubMed DOI
[YEAR:3-3-2005]Song,E.S., Daily,A., Fried,M.G., Juliano,M.A., Juliano,L. and Hersh,L.B. Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions J Biol Chem (3-3-2005) 280, 17701-17706. PubMed Europe PubMed DOI
Song,E.S. and Hersh,L.B. Insulysin: an allosteric enzyme as a target for Alzheimer's disease J Mol Neurosci (2005) 25, 201-206. PubMed Europe PubMed DOI

2004

[YEAR:27-7-2004]Bian,L., Yang,J.D., Guo,T.W., Sun,Y., Duan,S.W., Chen,W.Y., Pan,Y.X., Feng,G.Y. and He,L. Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese Neurology (27-7-2004) 63, 241-245. PubMed Europe PubMed M
Edland,S.D. Insulin-degrading enzyme, apolipoprotein e, and Alzheimer's disease J Mol Neurosci (2004) 23, 213-217. PubMed Europe PubMed DOI
Farris,W., Mansourian,S., Leissring,M.A., Eckman,E.A., Bertram,L., Eckman,C.B., Tanzi,R.E. and Selkoe,D.J. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein Am J Pathol (2004) 164, 1425-1434. PubMed Europe PubMed PMC EPMC
[YEAR:16-11-2004]Gao,W., Eisenhauer,P.B., Conn,K., Lynch,J.A., Wells,J.M., Ullman,M.D., McKee,A., Thatte,H.S. and Fine,R.E. Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells Neurosci Lett (16-11-2004) 371, 6-11. PubMed Europe PubMed DOI
Gu,H.F., Efendic,S., Nordman,S., Ostenson,C.G., Brismar,K., Brookes,A.J. and Prince,J.A. Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels Diabetes (2004) 53, 2137-2142. PubMed Europe PubMed DOI M
[YEAR:30-7-2004]Leissring,M.A., Farris,W., Wu,X., Christodoulou,D.C., Haigis,M.C., Guarente,L. and Selkoe,D.J. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria Biochem J (30-7-2004) 383, 439-446. PubMed Europe PubMed DOI PMC EPMC R
[YEAR:15-11-2004]Morelli,L., Llovera,R.E., Mathov,I., Lue,L.F., Frangione,B., Ghiso,J. and Castano,E.M. Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy J Biol Chem (15-11-2004) 279, 56004-56013. PubMed Europe PubMed DOI
Roth,R.A. Insulysin [ISSN:0-12-079610-4] (2004) 2, 871-876. V
[YEAR:15-2-2004]Sakai,A., Ujike,H., Nakata,K., Takehisa,Y., Imamura,T., Uchida,N., Kanzaki,A., Yamamoto,M., Fujisawa,Y., Okumura,K. and Kuroda,S. No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population Am J Med Genet B Neuropsychiatr Genet (15-2-2004) 125B, 87-91. PubMed Europe PubMed DOI M
[YEAR:19-11-2004]Song,E.S., Juliano,M.A., Juliano,L., Fried,M.G., Wagner,S.L. and Hersh,L.B. ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety J Biol Chem (19-11-2004) 279, 54216-54220. PubMed Europe PubMed DOI A
[YEAR:8-12-2004]Zhao,L., Teter,B., Morihara,T., Lim,G.P., Ambegaokar,S.S., Ubeda,O.J., Frautschy,S.A. and Cole,G.M. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention J Neurosci (8-12-2004) 24, 11120-11126. PubMed Europe PubMed DOI

2003

Bennett,R.G., Fawcett,J., Kruer,M.C., Duckworth,W.C. and Hamel,F.G. Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme J Endocrinol (2003) 177, 399-405. PubMed Europe PubMed DOI
Cook,D.G., Leverenz,J.B., McMillan,P.J., Kulstad,J.J., Ericksen,S., Roth,R.A., Schellenberg,G.D., Jin,L.W., Kovacina,K.S. and Craft,S. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele Am J Pathol (2003) 162, 313-319. PubMed Europe PubMed PMC EPMC
[YEAR:10-7-2003]Edland,S.D., Wavrant-De Vriese,F., Compton,D., Smith,G.E., Ivnik,R., Boeve,B.F., Tangalos,E.G. and Petersen,R.C. Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE) Neurosci Lett (10-7-2003) 345, 21-24. PubMed Europe PubMed DOI M
[YEAR:1-4-2003]Farris,W., Mansourian,S., Chang,Y., Lindsley,L., Eckman,E.A., Frosch,M.P., Eckman,C.B., Tanzi,R.E., Selkoe,D.J. and Guenette,S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo Proc Natl Acad Sci U S A (1-4-2003) 100, 4162-4167. PubMed Europe PubMed DOI PMC EPMC K
Groves,C.J., Wiltshire,S., Smedley,D., Owen,K.R., Frayling,T.M., Walker,M., Hitman,G.A., Levy,J.C., O'Rahilly,S., Menzel,S., Hattersley,A.T. and McCarthy,M.I. Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility Diabetes (2003) 52, 1300-1305. PubMed Europe PubMed DOI
Hamel,F.G., Upward,J.L. and Bennett,R.G. In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters Endocrinology (2003) 144, 2404-2408. PubMed Europe PubMed DOI
Karamohamed,S., Demissie,S., Volcjak,J., Liu,C., Heard-Costa,N., Liu,J., Shoemaker,C.M., Panhuysen,C.I., Meigs,J.B., Wilson,P., Atwood,L.D., Cupples,L.A. and Herbert,A. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study Diabetes (2003) 52, 1562-1567. PubMed Europe PubMed DOI M
[YEAR:13-5-2003]Miller,B.C., Eckman,E.A., Sambamurti,K., Dobbs,N., Chow,K.M., Eckman,C.B., Hersh,L.B. and Thiele,D.L. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo Proc Natl Acad Sci U S A (13-5-2003) 100, 6221-6226. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:30-6-2003]Saric,T., Muller,D., Seitz,H.J. and Pavelic,K. Non-covalent interaction of ubiquitin with insulin-degrading enzyme Mol Cell Endocrinol (30-6-2003) 204, 11-20. PubMed Europe PubMed DOI

2002

[YEAR:23-8-2002]Boussaha,M., Hannequin,D., Verpillat,P., Brice,A., Frebourg,T. and Campion,D. Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease Neurosci Lett (23-8-2002) 329, 121-123. PubMed Europe PubMed DOI M
[YEAR:19-4-2002]Edbauer,D., Willem,M., Lammich,S., Steiner,H. and Haass,C. Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD) J Biol Chem (19-4-2002) 277, 13389-13393. PubMed Europe PubMed DOI

2001

Abraham,R., Myers,A., Wavrant-DeVrieze,F., Hamshere,M.L., Thomas,H.V., Marshall,H., Compton,D., Spurlock,G., Turic,D., Hoogendoorn,B., Kwon,J.M., Petersen,R.C., Tangalos,E., Norton,J., Morris,J.C., Bullock,R., Liolitsa,D., Lovestone,S., Hardy,J., Goate,A., O'Donovan,M., Williams,J., Owen,M.J. and Jones,L. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease Hum Genet (2001) 109, 646-652. PubMed Europe PubMed DOI M
Camberos,M.C., rez,A.A., Udrisar,D.P., Wanderley,M.I. and Cresto,J.C. ATP inhibits insulin-degrading enzyme activity Exp Biol Med (Maywood) (2001) 226, 334-341. PubMed Europe PubMed
Kurochkin,I.V. Insulin-degrading enzyme: embarking on amyloid destruction Trends Biochem Sci (2001) 26, 421-425. PubMed Europe PubMed DOI
[YEAR:12-1-2001]Song,E.S., Mukherjee,A., Juliano,M.A., Pyrek,J.S., Goodman,J.P., Jr., Juliano,L. and Hersh,L.B. Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates J Biol Chem (12-1-2001) 276, 1152-1155. PubMed Europe PubMed DOI

2000

[YEAR:24-11-2000]Bennett,R.G., Duckworth,W.C. and Hamel,F.G. Degradation of amylin by insulin-degrading enzyme J Biol Chem (24-11-2000) 275, 36621-36625. PubMed Europe PubMed DOI
Chesneau,V. and Rosner,M.R. Functional human insulin-degrading enzyme can be expressed in bacteria Protein Expr Purif (2000) 19, 91-98. PubMed Europe PubMed DOI E
[YEAR:15-10-2000]Chesneau,V., Vekrellis,K., Rosner,M.R. and Selkoe,D.J. Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization Biochem J (15-10-2000) 351, 509-516. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-9-2000]Fakhrai-Rad,H., Nikoshkov,A., Kamel,A., Fernstrom,M., Zierath,J.R., Norgren,S., Luthman,H. and Galli,J. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats Hum Mol Genet (1-9-2000) 9, 2149-2158. PubMed Europe PubMed
Morita,M., Kurochkin,I.V., Motojima,K., Goto,S., Takano,T., Okamura,S., Sato,R., Yokota,S. and Imanaka,T. Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins Cell Struct Funct (2000) 25, 309-315. PubMed Europe PubMed DOI
[YEAR:1-12-2000]Mukherjee,A., Song,E., Kihiko-Ehmann,M., Goodman,J.P., Jr., St Pyrek,J., Estus,S. and Hersh,L.B. Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques J Neurosci (1-12-2000) 20, 8745-8749. PubMed Europe PubMed
Perez,A., Morelli,L., Cresto,J.C. and Castano,E.M. Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains Neurochem Res (2000) 25, 247-255. PubMed Europe PubMed DOI
[YEAR:1-3-2000]Vekrellis,K., Ye,Z., Qiu,W.Q., Walsh,D., Hartley,D., Chesneau,V., Rosner,M.R. and Selkoe,D.J. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme J Neurosci (1-3-2000) 20, 1657-1665. PubMed Europe PubMed

1998

[YEAR:17-3-1998]Duckworth,W.C., Bennett,R.G. and Hamel,F.G. Insulin acts intracellularly on proteasomes through insulin-degrading enzyme Biochem Biophys Res Commun (17-3-1998) 244, 390-394. PubMed Europe PubMed DOI
Duckworth,W.C., Bennett,R.G. and Hamel,F.G. Insulin degradation: progress and potential Endocr Rev (1998) 19, 608-624. PubMed Europe PubMed DOI
Hamel,F.G., Bennett,R.G. and Duckworth,W.C. Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme Endocrinology (1998) 139, 4061-4066. PubMed Europe PubMed DOI
[YEAR:4-12-1998]Qiu,W.Q., Walsh,D.M., Ye,Z., Vekrellis,K., Zhang,J., Podlisny,M.B., Rosner,M.R., Safavi,A., Hersh,L.B. and Selkoe,D.J. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation J Biol Chem (4-12-1998) 273, 32730-32738. PubMed Europe PubMed DOI
[YEAR:1-5-1998]Sarada,B., Thiele,D., Dang,T., Lee,J., Safavia,A., Hersh,L.B. and Cottam,G.L. Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular beta-endorphin endopeptidase (IDE/gamma-EpGE) J Neuroimmunol (1-5-1998) 85, 59-68. PubMed Europe PubMed DOI

1997

Bennett,R.G., Hamel,F.G. and Duckworth,W.C. Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex Diabetes (1997) 46, 197-203. PubMed Europe PubMed
Chesneau,V., Perlman,R.K., Li,W., Keller,G.A. and Rosner,M.R. Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation Endocrinology (1997) 138, 3444-3451. PubMed Europe PubMed DOI
Hamel,F.G., Gehm,B.D., Rosner,M.R. and Duckworth,W.C. Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes Biochim Biophys Acta (1997) 1338, 207-214. PubMed Europe PubMed DOI
Shearer,J.D., Coulter,C.F., Engeland,W.C., Roth,R.A. and Caldwell,M.D. Insulin is degraded extracellularly in wounds by insulin-degrading enzyme (EC 3.4.24.56) Am J Physiol (1997) 273, E657-E664. PubMed Europe PubMed

1996

Authier,F., Posner,B.I. and Bergeron,J.J. Insulin-degrading enzyme Clin Invest Med (1996) 19, 149-160. PubMed Europe PubMed
Authier,F., Cameron,P.H. and Taupin,V. Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells Biochem J (1996) 319, 149-158. PubMed Europe PubMed PMC EPMC
Safavi,A., Miller,B.C., Cottam,L. and Hersh,L.B. Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme Biochemistry (1996) 35, 14318-14325. PubMed Europe PubMed DOI

1995

Becker,A.B. and Roth,R.A. Insulysin and pitrilysin: insulin-degrading enzymes of mammals and bacteria Methods Enzymol (1995) 248, 693-703. PubMed Europe PubMed DOI V

1994

Kuo,W.L., Gehm,B.D., Rosner,M.R., Li,W. and Keller,G. Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line J Biol Chem (1994) 269, 22599-22606. PubMed Europe PubMed
[YEAR:23-5-1994]Kurochkin,I.V. and Goto,S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme FEBS Lett (23-5-1994) 345, 33-37. PubMed Europe PubMed DOI
Perlman,R.K. and Rosner,M.R. Identification of zinc ligands of the insulin-degrading enzyme J Biol Chem (1994) 269, 33140-33145. PubMed Europe PubMed
Saric,T., Seitz,H.J. and Pavelic,K. Detection of the substance immunologically cross-reactive with insulin in insulin RIA is an artifact caused by insulin tracer degradation: Involvement of the insulin-degrading enzyme Mol Cell Endocrinol (1994) 106, 23-29. PubMed Europe PubMed DOI

1993

[YEAR:15-2-1993]Baumeister,H., Muller,D., Rehbein,M. and Richter,D. The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts FEBS Lett (15-2-1993) 317, 250-254. PubMed Europe PubMed DOI
Gehm,B.D., Kuo,W.L., Perlman,R.K. and Rosner,M.R. Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding J Biol Chem (1993) 268, 7943-7948. PubMed Europe PubMed
Kuo,W.L., Montag,A.G. and Rosner,M.R. Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues Endocrinology (1993) 132, 604-611. PubMed Europe PubMed DOI
Perlman,R.K., Gehm,B.D., Kuo,W.L. and Rosner,M.R. Functional analysis of conserved residues in the active site of insulin-degrading enzyme J Biol Chem (1993) 268, 21538-21544. PubMed Europe PubMed

1992

[YEAR:1-1-1992]Carvalho,K.M., Joudiou,C., Boussetta,H., Leseney,A.M. and Cohen,P. A peptide-hormone-inactivating endopeptidase in Xenopus laevis skin secretion Proc Natl Acad Sci U S A (1-1-1992) 89, 84-88. PubMed Europe PubMed PMC EPMC
Ding,L., Becker,A.B., Suzuki,A. and Roth,R.A. Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III J Biol Chem (1992) 267, 2414-2420. PubMed Europe PubMed
Muller,D., Schulze,C., Baumeister,H., Buck,F. and Richter,D. Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry Biochemistry (1992) 31, 11138-11143. PubMed Europe PubMed DOI
Ogawa,W., Shii,K., Yonezawa,K., Baba,S. and Yokono,K. Affinity purification of insulin-degrading enzyme and its endogenous inhibitor from rat liver J Biol Chem (1992) 267, 1310-1316. PubMed Europe PubMed

1991

Rawlings,N.D. and Barrett,A.J. Homologues of insulinase, a new superfamily of metalloendopeptidases Biochem J (1991) 275, 389-391. PubMed Europe PubMed PMC EPMC

1990

Affholter,J.A., Hsieh,C.L., Francke,U. and Roth,R.A. Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes Mol Endocrinol (1990) 4, 1125-1135. PubMed Europe PubMed DOI
Duckworth,W.C., Hamel,F.G., Bennett,R., Ryan,M.P. and Roth,R.A. Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin J Biol Chem (1990) 265, 2984-2987. PubMed Europe PubMed
Kuo,W.L., Gehm,B.D. and Rosner,M.R. Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme Mol Endocrinol (1990) 4, 1580-1591. PubMed Europe PubMed DOI

1988

Affholter,J.A., Fried,V.A. and Roth,R.A. Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III Science (1988) 242, 1415-1418. PubMed Europe PubMed
Duckworth,W.C. Insulin degradation: mechanisms, products, and significance Endocr Rev (1988) 9, 319-345. PubMed Europe PubMed DOI
Garcia,J.V., Fenton,B.W. and Rosner,M.R. Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster Biochemistry (1988) 27, 4237-4244. PubMed Europe PubMed

1986

Shii,K. and Roth,R.A. Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease Proc Natl Acad Sci U S A (1986) 83, 4147-4151. PubMed Europe PubMed PMC EPMC

1985

Shii,K., Baba,S., Yokono,K. and Roth,R.A. Covalent linkage of 125I-insulin to a cytosolic insulin-degrading enzyme J Biol Chem (1985) 260, 6503-6506. PubMed Europe PubMed

1959

Tomizawa,H.H. and Halsey,Y.D. Isolation of an insulin-degrading enzyme from beef liver J Biol Chem (1959) 234, 307-310. PubMed Europe PubMed

1957

Mirsky,I.A. and Perisutti,G. Insulinase-inhibitory activity of protein hydrolysates Proc Soc Exp Biol Med (1957) 94, 589-592. PubMed Europe PubMed DOI I

1955

Beyer,R.E. A study of insulin metabolism in an insulin tolerant strain of mice Acta Endocrinol (Copenh) (1955) 19, 309-332. PubMed Europe PubMed