Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M16.002: insulysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Mancl,J.M., Liang,W.G., Bayhi,N.L., Wei,H., Carragher,B., Potter,C.S. and Tang,W.J.
    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity
    bioRxiv PubMed  Europe PubMed DOI
    2. 2024
  2. Geijtenbeek,K.W., Aranda,A.S., Sanz,A.S., Janzen,J., Bury,A.E., Kors,S., Al Amery,N., Schmitz,N.C.M., Reits,E.A.J. and Schipper-Krom,S.
    Insulin-Degrading Enzyme Efficiently Degrades polyQ Peptides but not Expanded polyQ Huntingtin Fragments
    J Huntingtons Dis13, 201-214. PubMed  Europe PubMed DOI
  3. Issac,L., Dolev,D., Irit,B., Assaf,D. and Levy,I.
    Assessment of insulin-degrading enzyme inhibitor for the treatment of corneal erosion in a rat model
    Graefes Arch Clin Exp Ophthalmol PubMed  Europe PubMed DOI  I
  4. Metwally,H.M., Younis,N.M., Abdel-Latif,E. and El-Rayyes,A.
    New thiazole, thiophene and 2-pyridone compounds incorporating dimethylaniline moiety: synthesis, cytotoxicity, ADME and molecular docking studies
    BMC Chem18, 52-52. PubMed  Europe PubMed DOI
  5. Zukowska,J., Moss,S.J., Subramanian,V. and Acharya,K.R.
    Molecular basis of selective amyloid-beta degrading enzymes in Alzheimer's disease
    FEBS J291, 2999-3029. PubMed  Europe PubMed DOI  V
    6. 2023
  6. Ambrozova,L., Zeman,T., Janout,V., Janoutova,J., Lochman,J. and Sery,O.
    Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report
    J Clin Lab Anal37, e24949-e24949. PubMed  Europe PubMed DOI
  7. Corraliza-Gomez,M., Bermejo,T., Lilue,J., Rodriguez-Iglesias,N., Valero,J., Cozar-Castellano,I., Arranz,E., Sanchez,D. and Ganfornina,M.D.
    Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging
    J Neuroinflammation20, 233-233. PubMed  Europe PubMed DOI
  8. Rao,F., Zhang,Z. and Li,J.
    Dynamical analysis of a glucose-insulin regulatory system with insulin-degrading enzyme and multiple delays
    J Math Biol87, 73-73. PubMed  Europe PubMed DOI
  9. Rowland,H.A., Moxon,S.R., Corbett,N.J., Hanson,K., Fisher,K., Kellett,K.A.B. and Hooper,N.M.
    Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-beta deposition
    Neuronal Signal7, NS20230016-NS20230016. PubMed  Europe PubMed DOI
  10. Tian,Y., Jing,G. and Zhang,M.
    Insulin-degrading enzyme: Roles and pathways in ameliorating cognitive impairment associated with Alzheimer's disease and diabetes
    Ageing Res Rev90, 101999-101999. PubMed  Europe PubMed DOI  V
  11. Tundo,G.R., Grasso,G., Persico,M., Tkachuk,O., Bellia,F., Bocedi,A., Marini,S., Parravano,M., Graziani,G., Fattorusso,C. and Sbardella,D.
    The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design
    Biomolecules13, PubMed  Europe PubMed DOI
  12. Yilmaz,A., Guerrera,C., Waeckel-Enee,E., Lipecka,J., Bertocci,B. and van Endert,P.
    Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins
    Biomolecules13, PubMed  Europe PubMed DOI
    13. 2022
  13. Azam,M.S., Wahiduzzaman,M., Reyad-Ul-Ferdous,M., Islam,M.N. and Roy,M.
    Inhibition of Insulin Degrading Enzyme to Control Diabetes Mellitus and its Applications on some Other Chronic Disease: a Critical Review
    Pharm Res39, 611-629. PubMed  Europe PubMed DOI  V
  14. Corraliza-Gomez,M., Lillo,C., Cozar-Castellano,I., Arranz,E., Sanchez,D. and Ganfornina,M.D.
    Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells
    Cells11, PubMed  Europe PubMed DOI
  15. Distefano,A., Caruso,G., Oliveri,V., Bellia,F., Sbardella,D., Zingale,G.A., Caraci,F. and Grasso,G.
    Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
    ACS Chem Neurosci13, 1588-1593. PubMed  Europe PubMed DOI
  16. Distefano,A., Antonio Zingale,G. and Grasso,G.
    An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme
    Anal Bioanal Chem414, 4793-4802. PubMed  Europe PubMed DOI
  17. Lesire,L., Leroux,F., Deprez-Poulain,R. and Deprez,B.
    Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?
    Cells11, PubMed  Europe PubMed DOI  V
  18. Martin-Martin,Y., Perez-Garcia,A., Torrecilla-Parra,M., Fernandez-de Frutos,M., Pardo-Marques,V., Casarejos,M.J., Busto,R. and Ramirez,C.M.
    New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs
    Cells11, PubMed  Europe PubMed DOI
  19. Pablos,M., Casanueva-Alvarez,E., Gonzalez-Casimiro,C.M., Merino,B., Perdomo,G. and Cozar-Castellano,I.
    Primary Cilia in Pancreatic beta- and alpha-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
    Front Endocrinol (Lausanne)13, 922825-922825. PubMed  Europe PubMed DOI  V
  20. Tundo,G.R., Sbardella,D., Oddone,F., Grasso,G., Marini,S., Atzori,M.G., Santoro,A.M., Milardi,D., Bellia,F., Macari,G., Graziani,G., Polticelli,F., Cascio,P., Parravano,M. and Coletta,M.
    Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug
    Biomolecules12, PubMed  Europe PubMed DOI  K  I
    21. 2021
  21. Adamek,R.N., Suire,C.N., Stokes,R.W., Brizuela,M.K., Cohen,S.M. and Leissring,M.A.
    Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme
    ChemMedChem PubMed  Europe PubMed DOI  I
  22. Hostachy,S., Utesch,T., Franke,K., Dornan,G.L., Furkert,D., Turkaydin,B., Haucke,V., Sun,H. and Fiedler,D.
    Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs
    Chem Sci12, 10696-10702. PubMed  Europe PubMed DOI
  23. Inoue,Y., Masuda,T., Misumi,Y., Ando,Y. and Ueda,M.
    Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus
    Neurosci Lett762, 136136-136136. PubMed  Europe PubMed DOI
  24. Leissring,M.A., Gonzalez-Casimiro,C.M., Merino,B., Suire,C.N. and Perdomo,G.
    Targeting Insulin-Degrading Enzyme in Insulin Clearance
    Int J Mol Sci22, PubMed  Europe PubMed DOI  V
  25. Leissring,M.A.
    Insulin-Degrading Enzyme: Paradoxes and Possibilities
    Cells10, PubMed  Europe PubMed DOI
  26. Li,C., Wang,Y., Zhu,G., Shang,Y., Jiefang,K. and Li,J.
    IL-6 induced enhanced clearance of proANP and ANP by insulin-degrading enzyme in T1DM mouse
    Biochem Cell Biol PubMed  Europe PubMed DOI
  27. Nash,Y., Ganoth,A., Borenstein-Auerbach,N., Levy-Barazany,H., Goldsmith,G., Kopelevich,A., Pozyuchenko,K., Sakhneny,L., Lazdon,E., Blanga-Kanfi,S., Alhadeff,R., Benromano,T., Landsman,L., Tsfadia,Y. and Frenkel,D.
    From virus to diabetes therapy: Characterization of a specific insulin-degrading enzyme inhibitor for diabetes treatment
    FASEB J35, e21374-e21374. PubMed  Europe PubMed DOI  I
  28. Ramaraju,B., Nelson,S.L., Zheng,W., Ghirlando,R. and Deshmukh,L.
    Quantitative NMR Study of Insulin-Degrading Enzyme Using Amyloid-beta and HIV-1 p6 Elucidates Its Chaperone Activity
    Biochemistry PubMed  Europe PubMed DOI
  29. Sousa,L., Guarda,M., Meneses,M.J., Macedo,M.P. and Vicente Miranda,H.
    Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases
    J Pathol PubMed  Europe PubMed DOI  V
  30. Waclawczyk,D., Silberring,J. and Grasso,G.
    The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism
    J Enzyme Inhib Med Chem36, 183-187. PubMed  Europe PubMed DOI
  31. Zheng,Q., Kebede,M.T., Lee,B., Krasinski,C.A., Islam,S., Wurfl,L.A., Kemeh,M.M., Ivancic,V.A., Jakobsche,C.E., Spratt,D.E. and Lazo,N.D.
    Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme
    Antioxidants (Basel)10, PubMed  Europe PubMed DOI  I
    32. 2020
  32. Bernstein,H.G., Keilhoff,G., Dobrowolny,H. and Steiner,J.
    Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme's implication for Alzheimer s disease pathology?
    Eur Arch Psychiatry Clin Neurosci270, 495-496. PubMed  Europe PubMed DOI
  33. Fu,H., Liu,B., Li,L. and Lemere,C.A.
    Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme
    Neuroscience443, 30-43. PubMed  Europe PubMed DOI
  34. Kim,N. and Lee,H.J.
    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
    Biomed Res Int2020, 2010728-2010728. PubMed  Europe PubMed DOI  V
  35. Lauer,A.A., Mett,J., Janitschke,D., Thiel,A., Stahlmann,C.P., Bachmann,C.M., Ritzmann,F., Schrul,B., Muller,U.C., Stein,R., Riemenschneider,M., Grimm,H.S., Hartmann,T. and Grimm,M.O.W.
    Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease
    Aging Celle13264-e13264. PubMed  Europe PubMed DOI
  36. Merino,B., Fernandez-Diaz,C.M., Parrado-Fernandez,C., Gonzalez-Casimiro,C.M., Postigo-Casado,T., Lobaton,C.D., Leissring,M.A., Cozar-Castellano,I. and Perdomo,G.
    Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice
    Metabolism113, 154352-154352. PubMed  Europe PubMed DOI
  37. Minchenko,D.O., Khita,O.O., Tsymbal,D.O., Danilovskyi,S.V., Rudnytska,O.V., Halkin,O.V., Kryvdiuk,I.V., Smeshkova,M.V., Yakymchuk,M.M., Bezrodnyi,B.H. and Minchenko,O.H.
    Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation
    Endocr Regul54, 183-195. PubMed  Europe PubMed DOI
  38. Suire,C.N., Brizuela,M.K. and Leissring,M.A.
    Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin
    Methods Protoc3, PubMed  Europe PubMed DOI
    39. 2019
  39. Bellia,F., Lanza,V., Ahmed,I.M.M., Garcia-Vinuales,S., Veiss,E., Arizzi,M., Calcagno,D., Milardi,D. and Grasso,G.
    Site directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus E1-like activity: the role of metal ions
    Metallomics11, 278-281. PubMed  Europe PubMed DOI
  40. Borges,D.O., Meneses,M.J., Dias,T.R., Martins,F.O., Oliveira,P.F., Alves,M.G. and Macedo,M.P.
    Data on metabolic profile of insulin-degrading enzyme knockout mice
    Data Brief25, 104023-104023. PubMed  Europe PubMed DOI  K
  41. Fernandez-Diaz,C.M., Merino,B., Lopez-Acosta,J.F., Cidad,P., de la Fuente,M.A., Lobaton,C.D., Moreno,A., Leissring,M.A., Perdomo,G. and Cozar-Castellano,I.
    Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity
    Am J Physiol Endocrinol Metab317, E805-E805. PubMed  Europe PubMed DOI  K
  42. Leng,Q.Y., Zheng,J.H., Xu,H.D., Adu-Asiamah,P., Zhang,Y., Du,B.W. and Zhang,L.
    [Cloning and expression analysis of chicken circular transcript of insulin degrading enzyme gene]
    Yi Chuan41, 1129-1137. PubMed  Europe PubMed DOI
  43. Leroux,F., Bosc,D., Beghyn,T., Hermant,P., Warenghem,S., Landry,V., Pottiez,V., Guillaume,V., Charton,J., Herledan,A., Urata,S., Liang,W., Sheng,L., Tang,W.J., Deprez,B. and Deprez-Poulain,R.
    Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening
    Eur J Med Chem179, 557-566. PubMed  Europe PubMed DOI  I
  44. Maianti,J.P., Tan,G.A., Vetere,A., Welsh,A.J., Wagner,B.K., Seeliger,M.A. and Liu,D.R.
    Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme
    Nat Chem Biol15, 565-574. PubMed  Europe PubMed DOI  S  I
  45. Meneses,M.J., Borges,D.O., Dias,T.R., Martins,F.O., Oliveira,P.F., Macedo,M.P. and Alves,M.G.
    Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality
    Mol Cell Endocrinol486, 11-17. PubMed  Europe PubMed DOI  K
  46. Zhang,S., Chen,L., Li,F., Li,N., Feng,Y. and Xiao,L.
    Divergent copies of a Cryptosporidium parvum-specific subtelomeric gene
    Microorganisms7, PubMed  Europe PubMed DOI
    47. 2018
  47. Grasso,G.
    Commentary on Ivancic et al.: Enzyme Kinetics from Circular Dichroism of Insulin Reveals Mechanistic Insights into the Regulation of Insulin-degrading Enzyme
    Biosci Rep38, BSR20181555-BSR20181555. PubMed  Europe PubMed DOI
  48. Hayrabedyan,S., Todorova,K., Spinelli,M., Barnea,E.R. and Mueller,M.
    The core sequence of PIF competes for insulin/amyloid beta in insulin degrading enzyme: potential treatment for Alzheimer's disease
    Oncotarget9, 33884-33895. PubMed  Europe PubMed DOI
  49. Ivancic,V.A., Krasinski,C.A., Zheng,Q., Meservier,R.J., Spratt,D.E. and Lazo,N.D.
    Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme
    Biosci Rep38, BSR20181416-BSR20181416. PubMed  Europe PubMed DOI
  50. Krasinski,C.A., Ivancic,V.A., Zheng,Q., Spratt,D.E. and Lazo,N.D.
    Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Abeta42
    ACS Omega3, 13275-13282. PubMed  Europe PubMed DOI  I
  51. Krasinski,C.A., Zheng,Q., Ivancic,V.A., Spratt,D.E. and Lazo,N.D.
    The longest amyloid-beta precursor protein intracellular domain produced with Abeta42 forms beta-sheet-containing monomers that self-assemble and are proteolyzed by insulin-degrading enzyme
    ACS Chem Neurosci9, 2892-2897. PubMed  Europe PubMed DOI
  52. Kurochkin,I.V., Guarnera,E. and Berezovsky,I.N.
    Insulin-degrading enzyme in the fight against Alzheimer's disease
    Trends Pharmacol Sci39, 49-58. PubMed  Europe PubMed DOI
  53. Lai,R., Tang,W.J. and Li,H.
    Catalytic mechanism of amyloid-beta peptide degradation by insulin degrading enzyme: insights from quantum mechanics and molecular mechanics style Moller-Plesset second order perturbation theory calculation
    J Chem Inf Model58, 1926-1934. PubMed  Europe PubMed DOI
  54. Stefanidis,L., Fusco,N.D., Cooper,S.E., Smith-Carpenter,J.E. and Alper,B.J.
    Molecular determinants of substrate specificity in human insulin-degrading enzyme
    Biochemistry57, 4903-4914. PubMed  Europe PubMed DOI
  55. Suire,C.N., Nainar,S., Fazio,M., Kreutzer,A.G., Paymozd-Yazdi,T., Topper,C.L., Thompson,C.R. and Leissring,M.A.
    Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display
    PLoS ONE13, e0193101-e0193101. PubMed  Europe PubMed DOI  I
  56. Villa-Perez,P., Merino,B., Fernandez-Diaz,C.M., Cidad,P., Lobaton,C.D., Moreno,A., Muturi,H.T., Ghadieh,H.E., Najjar,S.M., Leissring,M.A., Cozar-Castellano,I. and Perdomo,G.
    Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice
    Metabolism88, 1-11. PubMed  Europe PubMed DOI  K
  57. Yang,D., Qin,W., Shi,X., Zhu,B., Xie,M., Zhao,H., Teng,B., Wu,Y., Zhao,R., Yin,F., Ren,P., Liu,L. and Li,Z.
    Stabilized beta-hairpin peptide inhibits insulin degrading enzyme
    J Med Chem61, 8174-8185. PubMed  Europe PubMed DOI  I
  58. Zhang,Y. and Wang,P.
    Age-related increase of insulin-degrading enzyme is inversely correlated with cognitive function in APPswe/PS1dE9 mice
    Med Sci Monit24, 2446-2455. PubMed  Europe PubMed DOI
  59. Zhang,Z., Liang,W.G., Bailey,L.J., Tan,Y.Z., Wei,H., Wang,A., Farcasanu,M., Woods,V.A., McCord,L.A., Lee,D., Shang,W., Deprez-Poulain,R., Deprez,B., Liu,D.R., Koide,A., Koide,S., Kossiakoff,A.A., Li,S., Carragher,B., Potter,C.S. and Tang,W.J.
    Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
    elife7, PubMed  Europe PubMed DOI  S
    60. 2017
  60. Hahn,F., Schmalen,A., Setz,C., Friedrich,M., Schlosser,S., Kolle,J., Spranger,R., Rauch,P., Fraedrich,K., Reif,T., Karius-Fischer,J., Balasubramanyam,A., Henklein,P., Fossen,T. and Schubert,U.
    Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner
    PLoS ONE12, e0174254-e0174254. PubMed  Europe PubMed DOI
  61. Jamal,S., Goyal,S., Shanker,A. and Grover,A.
    Machine learning and molecular dynamics based insights into mode of actions of insulin degrading enzyme modulators
    Comb Chem High Throughput Screen20, 279-291. PubMed  Europe PubMed
  62. Kurochkin,I.V., Guarnera,E., Wong,J.H., Eisenhaber,F. and Berezovsky,I.N.
    Toward allosterically increased catalytic activity of insulin-degrading enzyme against amyloid peptides
    Biochemistry56, 228-239. PubMed  Europe PubMed DOI
  63. Li,H., Wu,J., Zhu,L., Sha,L., Yang,S., Wei,J., Ji,L., Tang,X., Mao,K., Cao,L., Wei,N., Xie,W. and Yang,Z.
    Insulin degrading enzyme contributes to the pathology in a mixed model of type 2 diabetes and Alzheimer's disease
    Biosci Rep38, BSR20170862-BSR20170862. PubMed  Europe PubMed DOI
  64. Song,E.S., Jang,H., Guo,H.F., Juliano,M.A., Juliano,L., Morris,A.J., Galperin,E., Rodgers,D.W. and Hersh,L.B.
    Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes
    Proc Natl Acad Sci U S A114, E2826-E2835. PubMed  Europe PubMed DOI
  65. Tundo,G.R., Sbardella,D., Ciaccio,C., Grasso,G., Gioia,M., Coletta,A., Polticelli,F., Di Pierro,D., Milardi,D., van Endert,P., Marini,S. and Coletta,M.
    Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
    Crit Rev Biochem Mol Biol52, 554-582. PubMed  Europe PubMed DOI
    66. 2016
  66. Cai,P., Zhong,W., Jia,M., Yu,C., Peng,Y., Wang,Y., Wang,H., Zeng,C., Bai,Y. and Wang,X.
    The gene polymorphisms of insulin degrading enzyme (IDE) are associated with the risk of coronary heart disease in Chinese Han population
    Int J Clin Exp Pathol9, 5544-5551.  M
  67. Grimm,M.O., Mett,J., Stahlmann,C.P., Haupenthal,V.J., Blumel,T., Stotzel,H., Grimm,H.S. and Hartmann,T.
    Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-beta by affecting insulin-degrading enzyme
    Biochem Cell Biol94, 534-542. PubMed  Europe PubMed DOI
  68. Hogan,M.F., Meier,D.T., Zraika,S., Templin,A.T., Mellati,M., Hull,R.L., Leissring,M.A. and Kahn,S.E.
    Inhibition of insulin-degrading enzyme does not increase islet amyloid deposition in vitro
    Endocrinology157, 3462-3468. PubMed  Europe PubMed DOI  I
  69. Hubin,E., Cioffi,F., Rozenski,J., Van Nuland,N.A. and Broersen,K.
    Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation states
    Biochim Biophys Acta1860, 1281-1290. PubMed  Europe PubMed DOI  P
  70. Lukman,S.
    Novel druggable sites of insulin-degrading enzyme identified through applied structural bioinformatics analysis
    Procedia Comput Sci80, 2292-2296. DOI  I
  71. Paul,T.J., Barman,A., Ozbil,M., Bora,R.P., Zhang,T., Sharma,G., Hoffmann,Z. and Prabhakar,R.
    Mechanisms of peptide hydrolysis by aspartyl and metalloproteases
    Phys Chem Chem Phys18, 24790-24801. PubMed  Europe PubMed DOI
  72. Pivovarova,O., Hohn,A., Grune,T., Pfeiffer,A.F. and Rudovich,N.
    Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?
    Ann Med48, 614-624. PubMed  Europe PubMed DOI  T  I
  73. Son,S.M., Cha,M.Y., Choi,H., Kang,S., Choi,H., Lee,M.S., Park,S.A. and Mook-Jung,I.
    Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease
    Autophagy12, 784-800. PubMed  Europe PubMed DOI
  74. Tang,W.J.
    Targeting insulin-degrading enzyme to treat type 2 diabetes mellitus
    Trends Endocrinol Metab27, 24-34. PubMed  Europe PubMed DOI  I
  75. Tundo,G.R., Di Muzio,E., Ciaccio,C., Sbardella,D., Di Pierro,D., Polticelli,F., Coletta,M. and Marini,S.
    Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin
    FEBS J283, 3755-3770. PubMed  Europe PubMed DOI
    76. 2015
  76. Abdul-Hay,S.O., Bannister,T.D., Wang,H., Cameron,M.D., Caulfield,T.R., Masson,A., Bertrand,J., Howard,E.A., McGuire,M.P., Crisafulli,U., Rosenberry,T.R., Topper,C.L., Thompson,C.R., Schurer,S.C., Madoux,F., Hodder,P. and Leissring,M.A.
    Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors
    ACS Chem Biol10, 2716-2724. PubMed  Europe PubMed DOI  I
  77. Charton,J., Gauriot,M., Totobenazara,J., Hennuyer,N., Dumont,J., Bosc,D., Marechal,X., Elbakali,J., Herledan,A., Wen,X., Ronco,C., Gras-Masse,H., Heninot,A., Pottiez,V., Landry,V., Staels,B., Liang,W.G., Leroux,F., Tang,W.J., Deprez,B. and Deprez-Poulain,R.
    Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme
    Eur J Med Chem90C, 547-567. PubMed  Europe PubMed DOI  S  I
  78. Cheng,H., Wang,L., Shi,T., Shang,Y. and Jiang,L.
    Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis
    Int J Neurosci125, 328-335. PubMed  Europe PubMed DOI  M
  79. Del Campo,M., Stargardt,A., Veerhuis,R., Reits,E. and Teunissen,C.E.
    Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Abeta by insulin degrading enzyme (IDE) in Alzheimer's disease
    Neurosci Lett589C, 47-51. PubMed  Europe PubMed DOI
  80. Deprez-Poulain,R., Hennuyer,N., Bosc,D., Liang,W.G., Enee,E., Marechal,X., Charton,J., Totobenazara,J., Berte,G., Jahklal,J., Verdelet,T., Dumont,J., Dassonneville,S., Woitrain,E., Gauriot,M., Paquet,C., Duplan,I., Hermant,P., Cantrelle,F.X., Sevin,E., Culot,M., Landry,V., Herledan,A., Piveteau,C., Lippens,G., Leroux,F., Tang,W.J., van Endert,P., Staels,B. and Deprez,B.
    Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
    Nat Commun6, 8250-8250. PubMed  Europe PubMed DOI  I
  81. Durham,T.B., Toth,J.L., Klimkowski,V.J., Cao,J.X., Siesky,A.M., Alexander-Chacko,J., Wu,G.Y., Dixon,J.T., McGee,J.E., Wang,Y., Guo,S.Y., Cavitt,R.N., Schindler,J., Thibodeaux,S.J., Calvert,N.A., Coghlan,M.J., Sindelar,D.K., Christe,M., Kiselyov,V.V., Michael,M.D. and Sloop,K.W.
    Dual exosite-binding inhibitors of insulin-degrading enzyme challenge its role as the primary mediator of insulin clearance in vivo
    J Biol Chem290, 20044-20059. PubMed  Europe PubMed DOI  K  I
  82. Grasso,G., Lanza,V., Malgieri,G., Fattorusso,R., Pietropaolo,A., Rizzarelli,E. and Milardi,D.
    The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin
    Chem Commun (Camb)51, 15724-15727. PubMed  Europe PubMed DOI
  83. Grasso,G., Satriano,C. and Milardi,D.
    A neglected modulator of insulin-degrading enzyme activity and conformation: the pH
    Biophys Chem203-204C, 33-40. PubMed  Europe PubMed DOI
  84. Grune,T.
    Insulin-degrading enzyme: Is it suitable for diabetes treatment?
    Cell Cycle14, 2553- PubMed  Europe PubMed DOI
  85. Gutierrez-Hermosillo,H., Diaz De Leon-Gonzalez,E., Palacios-Corona,R., Cedillo-Rodriguez,J.A., Camacho-Luis,A., Reyes-Romero,M.A., Medina-Chavez,J.H. and Blandon,P.A.
    C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study
    Med Clin (Barc)144, 151-155. PubMed  Europe PubMed DOI  M
  86. Jha,N.K., Jha,S.K., Kumar,D., Kejriwal,N., Sharma,R., Ambasta,R.K. and Kumar,P.
    Impact of insulin degrading enzyme and neprilysin in Alzheimer's disease biology: characterization of putative cognates for therapeutic applications
    J Alzheimers Dis48, 891-917. PubMed  Europe PubMed DOI
  87. Liang,W.G., Ren,M., Zhao,F. and Tang,W.J.
    Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme
    J Mol Biol427, 1345-1358. PubMed  Europe PubMed DOI
  88. Sbardella,D., Tundo,G.R., Sciandra,F., Bozzi,M., Gioia,M., Ciaccio,C., Tarantino,U., Brancaccio,A., Coletta,M. and Marini,S.
    Proteasome activity is affected by fluctuations in insulin-degrading enzyme distribution
    PLoS ONE10, e0132455-e0132455. PubMed  Europe PubMed DOI
  89. Sharma,S.K., Chorell,E. and Wittung-Stafshede,P.
    Insulin-degrading enzyme is activated by the C-terminus of alpha-synuclein
    Biochem Biophys Res Commun466, 192-195. PubMed  Europe PubMed DOI
  90. Sharma,S.K., Chorell,E., Steneberg,P., Vernersson-Lindahl,E., Edlund,H. and Wittung-Stafshede,P.
    Insulin-degrading enzyme prevents alpha-synuclein fibril formation in a nonproteolytical manner
    Sci Rep5, 12531-12531. PubMed  Europe PubMed DOI
  91. Son,S.M., Kang,S., Choi,H. and Mook-Jung,I.
    Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
    Mol Neurodegener10, 56-56. PubMed  Europe PubMed DOI
  92. Song,E.S., Ozbil,M., Zhang,T., Sheetz,M., Lee,D., Tran,D., Li,S., Prabhakar,R., Hersh,L.B. and Rodgers,D.W.
    An Extended Polyanion Activation Surface in Insulin Degrading Enzyme
    PLoS ONE10, e0133114-e0133114. PubMed  Europe PubMed DOI
  93. Tundo,G.R., Sbardella,D., De Pascali,S.A., Ciaccio,C., Coletta,M., Fanizzi,F.P. and Marini,S.
    Novel platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells
    J Biol Inorg Chem20, 101-108. PubMed  Europe PubMed DOI  I
  94. Vingtdeux,V., Chandakkar,P., Zhao,H., Blanc,L., Ruiz,S. and Marambaud,P.
    CALHM1 ion channel elicits amyloid-beta clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain
    J Cell Sci128, 2330-2338. PubMed  Europe PubMed DOI
  95. Wang,S., He,F. and Wang,Y.
    Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease
    J Geriatr Psychiatry Neurol28, 94-98. PubMed  Europe PubMed DOI  M
    96. 2014

  96. Therapy: Targeting insulin-degrading enzyme in diabetes mellitus
    Nat Rev Endocrinol10, 446-446. DOI  I
  97. Bellia,F. and Grasso,G.
    The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme
    J Mass Spectrom49, 274-279. PubMed  Europe PubMed DOI
  98. Charton,J., Gauriot,M., Guo,Q., Hennuyer,N., Marechal,X., Dumont,J., Hamdane,M., Pottiez,V., Landry,V., Sperandio,O., Flipo,M., Buee,L., Staels,B., Leroux,F., Tang,W.J., Deprez,B. and Deprez-Poulain,R.
    Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis
    Eur J Med Chem79, 184-193. PubMed  Europe PubMed DOI  I
  99. Costes,S. and Butler,P.C.
    Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes?
    Cell Metab20, 201-203. PubMed  Europe PubMed DOI
  100. Culina,S., Mauvais,F.X., Hsu,H.T., Burgevin,A., Guenette,S., Moser,A. and van Endert,P.
    No major role for insulin-degrading enzyme in antigen presentation by MHC molecules
    PLoS ONE9, e88365-e88365. PubMed  Europe PubMed DOI
  101. da Cruz,C.H. and Seabra,G.
    Molecular dynamics simulations reveal a novel mechanism for ATP inhibition of insulin degrading enzyme
    J Chem Inf Model54, 1380-1390. PubMed  Europe PubMed DOI
  102. Galagovsky,D., Katz,M.J., Acevedo,J.M., Sorianello,E., Glavic,A. and Wappner,P.
    The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner
    Mol Biol Cell25, 916-924. PubMed  Europe PubMed DOI
  103. Grasso,G., Mielczarek,P., Niedziolka,M. and Silberring,J.
    Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme
    Int J Mol Sci15, 16787-16799. PubMed  Europe PubMed DOI  P
  104. Haque,R. and Nazir,A.
    Insulin-degrading enzyme: a link between Alzheimer's and type 2 diabetes mellitus
    CNS Neurol Disord Drug Targets13, 259-264. PubMed  Europe PubMed
  105. Ito,S., Ohtsuki,S., Murata,S., Katsukura,Y., Suzuki,H., Funaki,M., Tachikawa,M. and Terasaki,T.
    Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-beta peptide in mouse brain capillary endothelial cells
    J Alzheimers Dis38, 185-200. PubMed  Europe PubMed DOI
  106. Kurklinsky,S., Abdul-Hay,S.O., McGuire,M.P., Howard,E.A., Knight,J. and Leissring,M.A.
    The blood glucose-lowering effect of racecadotril is not attributable to inhibition of insulin-degrading enzyme
    Horm Metab Res46, 73-74. PubMed  Europe PubMed DOI  I
  107. Maianti,J.P., McFedries,A., Foda,Z.H., Kleiner,R.E., Du,X.Q., Leissring,M.A., Tang,W.J., Charron,M.J., Seeliger,M.A., Saghatelian,A. and Liu,D.R.
    Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
    Nature511, 94-98. PubMed  Europe PubMed DOI  S  I
  108. Qiu,W.Q. and Zhu,H.
    Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?
    Front Aging Neurosci6, 186-186. PubMed  Europe PubMed DOI
  109. Shaik,N.A., Kaleemuddin,M., Banaganapalli,B., Khan,F., Shaik,N.S., Ajabnoor,G., Al-Harthi,S.E., Bondagji,N., Al-Aama,J.Y. and Elango,R.
    Structural and functional characterization of pathogenic non-synonymous genetic mutations of human insulin-degrading enzyme by in silico methods
    CNS Neurol Disord Drug Targets13, 517-532. PubMed  Europe PubMed DOI  M
    110. 2013
  110. Abdul-Hay,S.O., Lane,A.L., Caulfield,T.R., Claussin,C., Bertrand,J., Masson,A., Choudhry,S., Fauq,A.H., Maharvi,G.M. and Leissring,M.A.
    Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity
    J Med Chem56, 2246-2255. PubMed  Europe PubMed DOI  I
  111. Bellia,F., Pietropaolo,A. and Grasso,G.
    Formation of insulin fragments by insulin-degrading enzyme: the role of zinc(II) and cystine bridges
    J Mass Spectrom48, 135-140. PubMed  Europe PubMed DOI  P
  112. Caravaggio,J.W., Hasu,M., Maclaren,R., Thabet,M., Raizman,J.E., Veinot,J.P., Marcel,Y.L., Milne,R.W. and Whitman,S.C.
    Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice
    Cardiovasc Pathol22, 458-464. PubMed  Europe PubMed DOI  K
  113. Carty,N., Nash,K.R., Brownlow,M., Cruite,D., Wilcock,D., Selenica,M.L., Lee,D.C., Gordon,M.N. and Morgan,D.
    Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice
    PLoS ONE8, e59626-e59626. PubMed  Europe PubMed DOI  U
  114. de Tullio,M.B., Castelletto,V., Hamley,I.W., Martino Adami,P.V., Morelli,L. and Castano,E.M.
    Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic abeta peptide aggregates
    PLoS ONE8, e59113-e59113. PubMed  Europe PubMed DOI
  115. Leal,M.C., Magnani,N., Villordo,S., Buslje,C.M., Evelson,P., Castano,E.M. and Morelli,L.
    Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid beta (Abeta) peptide catabolism and functionality
    J Biol Chem288, 12920-12931. PubMed  Europe PubMed DOI
  116. Lifshitz,V., Benromano,T., Weiss,R., Blanga-Kanfi,S. and Frenkel,D.
    Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model
    Brain Behav Immun30, 143-149. PubMed  Europe PubMed DOI  K
  117. McCord,L.A., Liang,W.G., Dowdell,E., Kalas,V., Hoey,R.J., Koide,A., Koide,S. and Tang,W.J.
    Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme
    Proc Natl Acad Sci U S A110, 13827-13832. PubMed  Europe PubMed DOI  S
  118. Tundo,G.R., Sbardella,D., Ciaccio,C., Bianculli,A., Orlandi,A., Desimio,M.G., Arcuri,G., Coletta,M. and Marini,S.
    Insulin-degrading enzyme (IDE): a novel heat shock-like protein
    J Biol Chem288, 2281-2289. PubMed  Europe PubMed DOI
  119. Zhang,L., Ding,Q., Wang,P. and Wang,Z.
    An upstream promoter element blocks the reverse transcription of the mouse insulin-degrading enzyme gene
    Biochem Biophys Res Commun430, 26-31. PubMed  Europe PubMed DOI
  120. Zhang,L., Wang,P., Ding,Q. and Wang,Z.
    Transcriptional directionality of the human insulin-degrading enzyme promoter
    Mol Cell Biochem382, 237-242. PubMed  Europe PubMed DOI
  121. Zhang,Y., Wang,B., Wan,H., Zhou,Q. and Li,T.
    Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease
    Neurosci Lett541, 132-137. PubMed  Europe PubMed DOI  M
    122. 2012
  122. Cakir,B., Dagliyan,O., Dagyildiz,E., Baris,I., Kavakli,I.H., Kizilel,S. and Turkay,M.
    Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme
    PLoS ONE7, e31787-e31787. PubMed  Europe PubMed DOI
  123. Cui,P.J., Cao,L., Wang,Y., Deng,Y.L., Xu,W., Wang,G., Zhang,Y., Zheng,L., Fei,Q.Z., Zhang,T. and Chen,S.D.
    The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population
    J Clin Neurosci19, 745-749. PubMed  Europe PubMed DOI  M
  124. Grasso,G., Salomone,F., Tundo,G.R., Pappalardo,G., Ciaccio,C., Spoto,G., Pietropaolo,A., Coletta,M. and Rizzarelli,E.
    Metal ions affect insulin-degrading enzyme activity
    J Inorg Biochem117, 351-358. PubMed  Europe PubMed DOI
  125. Kukday,S.S., Manandhar,S.P., Ludley,M.C., Burriss,M.E., Alper,B.J. and Schmidt,W.K.
    Cell-permeable, small-molecule activators of the insulin-degrading enzyme
    J Biomol Screen17, 1348-1361. PubMed  Europe PubMed DOI
  126. Kummer,M.P., Hulsmann,C., Hermes,M., Axt,D. and Heneka,M.T.
    Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice
    J Neuroimmune Pharmacol7, 165-172. PubMed  Europe PubMed DOI
  127. Leal,M.C. and Morelli,L.
    Insulysin
    [ISSN:978-0-12-407744-7]3, 1415-1420. DOI
  128. Leal,M.C., Surace,E.I., Holgado,M.P., Ferrari,C.C., Tarelli,R., Pitossi,F., Wisniewski,T., Castano,E.M. and Morelli,L.
    Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Abeta metabolism
    Biochim Biophys Acta1823, 227-235. PubMed  Europe PubMed DOI
  129. Noinaj,N., Song,E.S., Bhasin,S., Alper,B.J., Schmidt,W.K., Hersh,L.B. and Rodgers,D.W.
    Anion activation site of insulin-degrading enzyme
    J Biol Chem287, 48-57. PubMed  Europe PubMed DOI
  130. Song,E.S., Melikishvili,M., Fried,M.G., Juliano,M.A., Juliano,L., Rodgers,D.W. and Hersh,L.B.
    Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation
    PLoS ONE7, e46790-e46790. PubMed  Europe PubMed DOI
    131. 2011
  131. Abdul-Hay,S.O., Kang,D., McBride,M., Li,L., Zhao,J. and Leissring,M.A.
    Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin tolerance
    PLoS ONE6, e20818-e20818. PubMed  Europe PubMed DOI  K
  132. Bartl,J., Scholz,C.J., Hinterberger,M., Jungwirth,S., Wichart,I., Rainer,M.K., Kneitz,S., Danielczyk,W., Tragl,K.H., Fischer,P., Riederer,P. and Grunblatt,E.
    Disorder-specific effects of polymorphisms at opposing ends of the insulin degrading enzyme gene
    BMC Med Genet12, 151-151. PubMed  Europe PubMed DOI
  133. Belbin,O., Crump,M., Bisceglio,G.D., Carrasquillo,M.M., Morgan,K. and Younkin,S.G.
    Multiple insulin degrading enzyme variants alter in vitro reporter gene expression
    PLoS ONE6, e21429-e21429. PubMed  Europe PubMed DOI  M
  134. Cordes,C.M., Bennett,R.G., Siford,G.L. and Hamel,F.G.
    Redox regulation of insulin degradation by insulin-degrading enzyme
    PLoS ONE6, e18138-e18138. PubMed  Europe PubMed DOI
  135. Glebov,K., Schutze,S. and Walter,J.
    Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme
    J Biol Chem286, 22711-22715. PubMed  Europe PubMed DOI
  136. Hyun,J. and Hashimoto,C.
    Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila
    Fly (Austin)5, 53-57. PubMed  Europe PubMed DOI
  137. Kim,M.S., Goo,J.S., Kim,J.E., Nam,S.H., Choi,S.I., Lee,H.R., Hwang,I.S., Shim,S.B., Jee,S.W., Lee,S.H., Bae,C.J., Cho,J.S., Cho,J.Y. and Hwang,D.Y.
    Overexpression of insulin degrading enzyme could greatly contribute to insulin down-regulation induced by short-term swimming exercise
    Lab Anim Res27, 29-36. PubMed  Europe PubMed DOI
  138. Lee,J.P., Cheng,K.C., Chung,H.H., Wu,H.T., Chen,C.T. and Cheng,J.T.
    Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats
    Horm Metab Res43, 489-493. PubMed  Europe PubMed DOI  I
  139. Noinaj,N., Bhasin,S.K., Song,E.S., Scoggin,K.E., Juliano,M.A., Juliano,L., Hersh,L.B. and Rodgers,D.W.
    Identification of the allosteric regulatory site of insulysin
    PLoS ONE6, e20864-e20864. PubMed  Europe PubMed DOI  S
  140. Ralat,L.A., Kalas,V., Zheng,Z., Goldman,R.D., Sosnick,T.R. and Tang,W.J.
    Ubiquitin is a novel substrate for human insulin-degrading enzyme
    J Mol Biol406, 454-466. PubMed  Europe PubMed DOI  P
  141. Ralat,L.A., Guo,Q., Ren,M., Funke,T., Dickey,D.M., Potter,L.R. and Tang,W.J.
    Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response
    J Biol Chem286, 4670-4679. PubMed  Europe PubMed DOI
  142. Song,E.S., Rodgers,D.W. and Hersh,L.B.
    Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism
    J Biol Chem286, 13852-13858. PubMed  Europe PubMed DOI
  143. Zhao,L., Yao,J., Mao,Z., Chen,S., Wang,Y. and Brinton,R.D.
    17beta-Estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention
    Neurobiol Aging32, 1949-1963. PubMed  Europe PubMed DOI
    144. 2010
  144. Bannister,T.D., Wang,H., Abdul-Hay,S.O., Masson,A., Madoux,F., Ferguson,J., Mercer,B.A., Schurer,S., Zuhl,A., Cravatt,B.F., Leissring,M.A. and Hodder,P.
    ML345: A small-molecule inhibitor of the insulin-degrading enzyme (IDE)
     PubMed  Europe PubMed  I
  145. Bora,R.P., Ozbil,M. and Prabhakar,R.
    Elucidation of insulin degrading enzyme catalyzed site specific hydrolytic cleavage of amyloid beta peptide: a comparative density functional theory study
    J Biol Inorg Chem15, 485-495. PubMed  Europe PubMed DOI  P
  146. Bora,R.P. and Prabhakar,R.
    Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study
    Biochemistry49, 3947-3956. PubMed  Europe PubMed DOI
  147. Bulloj,A., Leal,M.C., Xu,H., Castano,E.M. and Morelli,L.
    Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease
    J Alzheimers Dis19, 79-95. PubMed  Europe PubMed DOI
  148. Carpenter,J.E., Jackson,W., de Souza,G.A., Haarr,L. and Grose,C.
    Insulin-degrading enzyme binds to the nonglycosylated precursor of varicella-zoster virus gE protein found in the endoplasmic reticulum
    J Virol84, 847-855. PubMed  Europe PubMed DOI
  149. Carrasquillo,M.M., Belbin,O., Zou,F., Allen,M., Ertekin-Taner,N., Ansari,M., Wilcox,S.L., Kashino,M.R., Ma,L., Younkin,L.H., Younkin,S.G., Younkin,C.S., Dincman,T.A., Howard,M.E., Howell,C.C., Stanton,C.M., Watson,C.M., Crump,M., Vitart,V., Hayward,C., Hastie,N.D., Rudan,I., Campbell,H., Polasek,O., Brown,K., Passmore,P., Craig,D., McGuinness,B., Todd,S., Kehoe,P.G., Mann,D.M., Smith,A.D., Beaumont,H., Warden,D., Holmes,C., Heun,R., Kolsch,H., Kalsheker,N., Pankratz,V.S., Dickson,D.W., Graff-Radford,N.R., Petersen,R.C., Wright,A.F., Younkin,S.G. and Morgan,K.
    Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease
    PLoS ONE5, e8764-e8764. PubMed  Europe PubMed DOI  M
  150. Chen,P.T., Liao,T.Y., Hu,C.J., Wu,S.T., Wang,S.S. and Chen,R.P.
    A highly sensitive peptide substrate for detecting two Abeta-degrading enzymes: neprilysin and insulin-degrading enzyme
    J Neurosci Methods190, 57-62. PubMed  Europe PubMed DOI  A
  151. Du,J., Zhang,L., Liu,S. and Wang,Z.
    Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons
    Pharmazie65, 231-232. PubMed  Europe PubMed DOI
  152. Guo,Q., Manolopoulou,M., Bian,Y., Schilling,A.B. and Tang,W.J.
    Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme
    J Mol Biol395, 430-443. PubMed  Europe PubMed DOI  P
  153. Leissring,M.A., Malito,E., Hedouin,S., Reinstatler,L., Sahara,T., Abdul-Hay,S.O., Choudhry,S., Maharvi,G.M., Fauq,A.H., Huzarska,M., May,P.S., Choi,S., Logan,T.P., Turk,B.E., Cantley,L.C., Manolopoulou,M., Tang,W.J., Stein,R.L., Cuny,G.D. and Selkoe,D.J.
    Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin
    PLoS ONE5, e10504-e10504. PubMed  Europe PubMed DOI  S  I
  154. Parmentier,N., Stroobant,V., Colau,D., de Diesbach,P., Morel,S., Chapiro,J., van Endert,P. and Van den Eynde,B.J.
    Production of an antigenic peptide by insulin-degrading enzyme
    Nat Immunol11, 449-454. PubMed  Europe PubMed DOI
  155. Ren,M., Guo,Q., Guo,L., Lenz,M., Qian,F., Koenen,R.R., Xu,H., Schilling,A.B., Weber,C., Ye,R.D., Dinner,A.R. and Tang,W.J.
    Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme
    EMBO J29, 3952-3966. PubMed  Europe PubMed DOI
  156. Song,E.S., Rodgers,D.W. and Hersh,L.B.
    A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties
    PLoS ONE5, e9719-e9719. PubMed  Europe PubMed DOI
  157. Tamboli,I.Y., Barth,E., Christian,L., Siepmann,M., Kumar,S., Singh,S., Tolksdorf,K., Heneka,M.T., Lutjohann,D., Wunderlich,P. and Walter,J.
    Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
    J Biol Chem285, 37405-37414. PubMed  Europe PubMed DOI
  158. Tsuda,M., Kobayashi,T., Matsuo,T. and Aigaki,T.
    Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila
    FEBS Lett584, 2916-2920. PubMed  Europe PubMed DOI  K
  159. Zhang,W.J., Luo,X. and Guo,Z.Y.
    In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme
    Protein J29, 93-98. PubMed  Europe PubMed DOI  P
    160. 2009
  160. Ali,M.A., Li,Q., Fischer,E.R. and Cohen,J.I.
    The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection
    Virology386, 270-279. PubMed  Europe PubMed DOI
  161. Amata,O., Marino,T., Russo,N. and Toscano,M.
    Human insulin-degrading enzyme working mechanism
    J Am Chem Soc131, 14804-14811. PubMed  Europe PubMed DOI
  162. Bennett,R.G., Heimann,D.G. and Hamel,F.G.
    Degradation of relaxin family peptides by insulin-degrading enzyme
    Ann N Y Acad Sci1160, 38-41. PubMed  Europe PubMed DOI
  163. Cabrol,C., Huzarska,M.A., Dinolfo,C., Rodriguez,M.C., Reinstatler,L., Ni,J., Yeh,L.A., Cuny,G.D., Stein,R.L., Selkoe,D.J. and Leissring,M.A.
    Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening
    PLoS ONE4, e5274-e5274. PubMed  Europe PubMed DOI
  164. Chou,Y.H., Kuo,W.L., Rosner,M.R., Tang,W.J. and Goldman,R.D.
    Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme
    FASEB J23, 3734-3742. PubMed  Europe PubMed DOI
  165. Ciaccio,C., Tundo,G.R., Grasso,G., Spoto,G., Marasco,D., Ruvo,M., Gioia,M., Rizzarelli,E. and Coletta,M.
    Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity
    J Mol Biol385, 1556-1567. PubMed  Europe PubMed DOI  P
  166. Cordes,C.M., Bennett,R.G., Siford,G.L. and Hamel,F.G.
    Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation
    Biochem Pharmacol77, 1064-1073. PubMed  Europe PubMed DOI  I
  167. Delledonne,A., Kouri,N., Reinstatler,L., Sahara,T., Li,L., Zhao,J., Dickson,D.W., Ertekin-Taner,N. and Leissring,M.A.
    Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme
    Mol Neurodegener4, 39-39. PubMed  Europe PubMed DOI
  168. Du,J., Zhang,L., Liu,S., Zhang,C., Huang,X., Li,J., Zhao,N. and Wang,Z.
    PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons
    Biochem Biophys Res Commun383, 485-490. PubMed  Europe PubMed DOI
  169. Fawcett,J. and Duckworth,W.C.
    Hyperglycaemia and hyperinsulinaemia: is insulin-degrading enzyme the missing link?
    Diabetologia52, 1457-1460. PubMed  Europe PubMed DOI
  170. Fernandez-Gamba,A., Leal,M.C., Morelli,L. and Castano,E.M.
    Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease
    Curr Pharm Des15, 3644-3655. PubMed  Europe PubMed DOI  V
  171. Grasso,G., Rizzarelli,E. and Spoto,G.
    The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study
    J Mass Spectrom44, 735-741. PubMed  Europe PubMed DOI  P
  172. Grasso,G., Bush,A.I., D'Agata,R., Rizzarelli,E. and Spoto,G.
    Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme
    Eur Biophys J38, 407-414. PubMed  Europe PubMed DOI
  173. Hulse,R.E., Ralat,L.A. and Wei-Jen,T.
    Structure, function, and regulation of insulin-degrading enzyme
    Vitam Horm80, 635-648. PubMed  Europe PubMed DOI  V
  174. Lu,X., Huang,Y., Liu,Y., Wu,X. and Shi,X.
    Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders
    Metabolism58, 1465-1469. PubMed  Europe PubMed DOI  M
  175. Manolopoulou,M., Guo,Q., Malito,E., Schilling,A.B. and Tang,W.J.
    Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme
    J Biol Chem284, 14177-14188. PubMed  Europe PubMed DOI
  176. Miners,J.S., Baig,S., Tayler,H., Kehoe,P.G. and Love,S.
    Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity
    J Neuropathol Exp Neurol68, 902-914. PubMed  Europe PubMed DOI
  177. Ralat,L.A., Ren,M., Schilling,A.B. and Tang,W.J.
    Protective role of CYS-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation
    J Biol Chem284, 34005-34018. PubMed  Europe PubMed DOI
  178. Rudovich,N., Pivovarova,O., Fisher,E., Fischer-Rosinsky,A., Spranger,J., Mohlig,M., Schulze,M.B., Boeing,H. and Pfeiffer,A.F.
    Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes
    J Mol Med87, 1145-1151. PubMed  Europe PubMed DOI  M
  179. Slominsky,P.A., Pivovarova,O.V., Shadrina,M.I., Artem'Eva,A.V., Pfaipffer,F.G., Rudovich,N.N., Agadghanyan,S.E., Pronin,V.S. and Limborska,S.A.
    Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population
    Russ J Genet45, 113-117. DOI  M
  180. Vepsalainen,S., Helisalmi,S., Mannermaa,A., Pirttila,T., Soininen,H. and Hiltunen,M.
    Combined risk effects of IDE and NEP gene variants on Alzheimer disease
    J Neurol Neurosurg Psychiatry80, 1268-1270. PubMed  Europe PubMed DOI  M
  181. Zhao,J., Li,L. and Leissring,M.A.
    Insulin-degrading enzyme is exported via an unconventional protein secretion pathway
    Mol Neurodegener4, 4-4. PubMed  Europe PubMed DOI
  182. Zuo,X. and Jia,J.
    Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease
    Brain Res1249, 1-8. PubMed  Europe PubMed DOI  M
    183. 2008
  183. Bernstein,H.G., Lendeckel,U., Bukowska,A., Ansorge,S., Ernst,T., Stauch,R., Trubner,K., Steiner,J., Dobrowolny,H. and Bogerts,B.
    Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
    J Chem Neuroanat35, 216-224. PubMed  Europe PubMed DOI
  184. Bulloj,A., Leal,M.C., Surace,E.I., Zhang,X., Xu,H., Ledesma,M.D., Castano,E.M. and Morelli,L.
    Detergent resistant membrane-associated IDE in brain tissue and cultured cells: relevance to Abeta and insulin degradation
    Mol Neurodegener3, 22-22. PubMed  Europe PubMed DOI
  185. de Tullio,M.B., Morelli,L. and Castano,E.M.
    The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective
    Prion2, 51-56. PubMed  Europe PubMed
  186. Epting,C.L., King,F.W., Pedersen,A., Zaman,J., Ritner,C. and Bernstein,H.S.
    Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts
    J Cell Physiol217, 250-260. PubMed  Europe PubMed DOI
  187. Grasso,G., Rizzarelli,E. and Spoto,G.
    How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin
    Biochim Biophys Acta1784, 1122-1126. PubMed  Europe PubMed DOI
  188. Hong,M.G., Reynolds,C., Gatz,M., Johansson,B., Palmer,J.C., Gu,H.F., Blennow,K., Kehoe,P.G., de Faire,U., Pedersen,N.L. and Prince,J.A.
    Evidence that the gene encoding insulin degrading enzyme influences human lifespan
    Hum Mol Genet17, 2370-2378. PubMed  Europe PubMed DOI  M
  189. Kwak,S.H., Cho,Y.M., Moon,M.K., Kim,J.H., Park,B.L., Cheong,H.S., Shin,H.D., Jang,H.C., Kim,S.Y., Lee,H.K. and Park,K.S.
    Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population
    Diabetes Res Clin Pract79, 284-290. PubMed  Europe PubMed DOI  M
  190. Llovera,R.E., de Tullio,M., Alonso,L.G., Leissring,M.A., Kaufman,S.B., Roher,A.E., de Prat Gay,G., Morelli,L. and Castano,E.M.
    The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis
    J Biol Chem283, 17039-17048. PubMed  Europe PubMed DOI
  191. Malito,E., Ralat,L.A., Manolopoulou,M., Tsay,J.L., Wadlington,N.L. and Tang,W.J.
    Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme
    Biochemistry47, 12822-12834. PubMed  Europe PubMed DOI  S
  192. Malito,E., Hulse,R.E. and Tang,W.J.
    Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
    Cell Mol Life Sci65, 2574-2585. PubMed  Europe PubMed DOI
  193. Miners,J.S., Kehoe,P.G. and Love,S.
    Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates
    J Neurosci Methods169, 177-181. PubMed  Europe PubMed DOI  A
  194. Neant-Fery,M., Garcia-Ordonez,R.D., Logan,T.P., Selkoe,D.J., Li,L., Reinstatler,L. and Leissring,M.A.
    Molecular basis for the thiol sensitivity of insulin-degrading enzyme
    Proc Natl Acad Sci U S A105, 9582-9587. PubMed  Europe PubMed DOI
  195. Wang,K., You,L., Shi,Y., Wang,L., Zhang,M. and Chen,Z.J.
    Association of genetic variants of insulin degrading enzyme with metabolic features in women with polycystic ovary syndrome
    Fertil Steril90, 378-384. PubMed  Europe PubMed DOI  M
  196. Weirich,G., Mengele,K., Yfanti,C., Gkazepis,A., Hellmann,D., Welk,A., Giersig,C., Kuo,W.L., Rosner,M.R., Tang,W.J. and Schmitt,M.
    Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines
    Biol Chem389, 1441-1445. PubMed  Europe PubMed DOI
  197. Yfanti,C., Mengele,K., Gkazepis,A., Weirich,G., Giersig,C., Kuo,W.L., Tang,W.J., Rosner,M. and Schmitt,M.
    Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues
    Int J Mol Med22, 421-431. PubMed  Europe PubMed DOI
    198. 2007
  198. Del Carmen Camberos,M. and Cresto,J.C.
    Insulin-degrading enzyme hydrolyzes ATP
    Exp Biol Med (Maywood)232, 281-292. PubMed  Europe PubMed
  199. Fawcett,J., Permana,P.A., Levy,J.L. and Duckworth,W.C.
    Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing
    Arch Biochem Biophys468, 128-133. PubMed  Europe PubMed DOI
  200. Grasso,G., Rizzarelli,E. and Spoto,G.
    AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin
    J Mass Spectrom42, 1590-1598. PubMed  Europe PubMed DOI  P
  201. Im,H., Manolopoulou,M., Malito,E., Shen,Y., Zhao,J., Neant-Fery,M., Sun,C.Y., Meredith,S.C., Sisodia,S.S., Leissring,M.A. and Tang,W.J.
    Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE
    J Biol Chem282, 25453-25463. PubMed  Europe PubMed DOI  S
  202. Kim,M., Hersh,L.B., Leissring,M.A., Ingelsson,M., Matsui,T., Farris,W., Lu,A., Hyman,B.T., Selkoe,D.J., Bertram,L. and Tanzi,R.E.
    Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families
    J Biol Chem282, 7825-7832. PubMed  Europe PubMed DOI
  203. Li,Q., Krogmann,T., Ali,M.A., Tang,W.J. and Cohen,J.I.
    The amino terminus of Varicella-Zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor
    J Virol81, 8525-8532. PubMed  Europe PubMed DOI
  204. Radulescu,R.T., Hufnagel,C., Luppa,P., Hellebrand,H., Kuo,W.L., Rosner,M.R., Harbeck,N., Giersig,C., Meindl,A., Schmitt,M. and Weirich,G.
    Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels
    Int J Oncol30, 73-80. PubMed  Europe PubMed
  205. Vepsalainen,S., Parkinson,M., Helisalmi,S., Mannermaa,A., Soininen,H., Tanzi,R.E., Bertram,L. and Hiltunen,M.
    Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population
    J Med Genet44, 606-608. PubMed  Europe PubMed DOI
  206. Zhao,Z., Xiang,Z., Haroutunian,V., Buxbaum,J.D., Stetka,B. and Pasinetti,G.M.
    Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease
    Neurobiol Aging28, 824-830. PubMed  Europe PubMed DOI
    207. 2006
  207. Florez,J.C., Wiltshire,S., Agapakis,C.M., Burtt,N.P., de Bakker,P.I., Almgren,P., Bengtsson Bostrom,K., Tuomi,T., Gaudet,D., Daly,M.J., Hirschhorn,J.N., McCarthy,M.I., Altshuler,D. and Groop,L.
    High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with Type 2 diabetes in 4,206 people
    Diabetes55, 128-135. PubMed  Europe PubMed DOI  M
  208. [YEAR:4-9-2006]Hersh,L.B.
    The insulysin (insulin degrading enzyme) enigma
    Cell Mol Life Sci63, 2432-2434. PubMed  Europe PubMed DOI  V
  209. [YEAR:19-10-2006]Leissring,M.A. and Selkoe,D.J.
    Structural biology: enzyme target to latch on to
    Nature443, 761-762. PubMed  Europe PubMed DOI
  210. [YEAR:22-3-2006]Li,P., Kuo,W.L., Yousef,M., Rosner,M.R. and Tang,W.J.
    The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition
    Biochem Biophys Res Commun343, 1032-1037. PubMed  Europe PubMed DOI
  211. Li,Q., Ali,M.A. and Cohen,J.I.
    Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread
    Cell127, 305-316. PubMed  Europe PubMed DOI
  212. [YEAR:1-3-2006]Lynch,J.A., George,A.M., Eisenhauer,P.B., Conn,K., Gao,W., Carreras,I., Wells,J.M., McKee,A., Ullman,M.D. and Fine,R.E.
    Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures
    J Neurosci Res83, 1262-1270. PubMed  Europe PubMed DOI
  213. Marlowe,L., Peila,R., Benke,K.S., Hardy,J., White,L.R., Launer,L.J. and Myers,A.
    Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk
    Neurodegener Dis3, 320-326. PubMed  Europe PubMed DOI  M
  214. [YEAR:14-8-2006]Ozturk,A., DeKosky,S.T. and Kamboh,M.I.
    Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease
    Neurosci Lett406, 265-269. PubMed  Europe PubMed DOI  M
  215. Qiu,W.Q. and Folstein,M.F.
    Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis
    Neurobiol Aging27, 190-198. PubMed  Europe PubMed DOI
  216. [YEAR:19-10-2006]Shen,Y., Joachimiak,A., Rosner,M.R. and Tang,W.J.
    Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
    Nature443, 870-874. PubMed  Europe PubMed DOI  S
  217. [YEAR:19-12-2006]Song,E.S., Cady,C., Fried,M.G. and Hersh,L.B.
    Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation
    Biochemistry45, 15085-15091. PubMed  Europe PubMed DOI
  218. [YEAR:6-5-2006]Yao,H. and Hersh,L.B.
    Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin
    Arch Biochem Biophys451, 175-181. PubMed  Europe PubMed DOI
    219. 2005
  219. [YEAR:3-5-2005]Farris,W., Leissring,M.A., Hemming,M.L., Chang,A.Y. and Selkoe,D.J.
    Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein
    Biochemistry44, 6513-6525. PubMed  Europe PubMed DOI  R
  220. [YEAR:27-4-2005]Feuk,L., McCarthy,S., Andersson,B., Prince,J.A. and Brookes,A.J.
    Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease
    Am J Med Genet B Neuropsychiatr Genet136B, 69-71. PubMed  Europe PubMed DOI
  221. Hwang,D.Y., Cho,J.S., Kim,C.K., Shim,S.B., Jee,S.W., Lee,S.H., Seo,S.J., Cho,J.Y., Lee,S.H. and Kim,Y.K.
    Aging-related correlation of insulin-degrading enzyme with gamma-secretase-generated products involving insulin and glucose levels in transgenic mice
    Neurochem Res30, 1171-1177. PubMed  Europe PubMed DOI
  222. [YEAR:8-6-2005]Kim,S., Lapham,A.N., Freedman,C.G., Reed,T.L. and Schmidt,W.K.
    Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme
    J Biol Chem280, 27481-27490. PubMed  Europe PubMed DOI  E
  223. [YEAR:8-7-2005]Morelli,L., Llovera,R.E., Alonso,L.G., Frangione,B., de Prat-Gay,G., Ghiso,J. and Castano,E.M.
    Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia
    Biochem Biophys Res Commun332, 808-816. PubMed  Europe PubMed DOI
  224. [YEAR:27-4-2005]Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T., Holmans,P., Hamshere,M., Turic,D., Jehu,L., Hollingworth,P., Moore,P., Bryden,L., Myers,A., Doil,L.M., Tacey,K.M., Gibson,A.M., McKeith,I.G., Perry,R.H., Morris,C.M., Thal,L., Morris,J.C., O'Donovan,M.C., Lovestone,S., Grupe,A., Hardy,J., Owen,M.J., Williams,J. and Goate,A.
    Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme
    Am J Med Genet B Neuropsychiatr Genet136B, 62-68. PubMed  Europe PubMed DOI
  225. [YEAR:3-3-2005]Song,E.S., Daily,A., Fried,M.G., Juliano,M.A., Juliano,L. and Hersh,L.B.
    Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions
    J Biol Chem280, 17701-17706. PubMed  Europe PubMed DOI
  226. Song,E.S. and Hersh,L.B.
    Insulysin: an allosteric enzyme as a target for Alzheimer's disease
    J Mol Neurosci25, 201-206. PubMed  Europe PubMed DOI
    227. 2004
  227. [YEAR:27-7-2004]Bian,L., Yang,J.D., Guo,T.W., Sun,Y., Duan,S.W., Chen,W.Y., Pan,Y.X., Feng,G.Y. and He,L.
    Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese
    Neurology63, 241-245. PubMed  Europe PubMed  M
  228. Edland,S.D.
    Insulin-degrading enzyme, apolipoprotein e, and Alzheimer's disease
    J Mol Neurosci23, 213-217. PubMed  Europe PubMed DOI
  229. Farris,W., Mansourian,S., Leissring,M.A., Eckman,E.A., Bertram,L., Eckman,C.B., Tanzi,R.E. and Selkoe,D.J.
    Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
    Am J Pathol164, 1425-1434. PubMed  Europe PubMed
  230. [YEAR:16-11-2004]Gao,W., Eisenhauer,P.B., Conn,K., Lynch,J.A., Wells,J.M., Ullman,M.D., McKee,A., Thatte,H.S. and Fine,R.E.
    Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells
    Neurosci Lett371, 6-11. PubMed  Europe PubMed DOI
  231. Gu,H.F., Efendic,S., Nordman,S., Ostenson,C.G., Brismar,K., Brookes,A.J. and Prince,J.A.
    Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels
    Diabetes53, 2137-2142. PubMed  Europe PubMed DOI  M
  232. [YEAR:30-7-2004]Leissring,M.A., Farris,W., Wu,X., Christodoulou,D.C., Haigis,M.C., Guarente,L. and Selkoe,D.J.
    Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria
    Biochem J383, 439-446. PubMed  Europe PubMed DOI  R
  233. [YEAR:15-11-2004]Morelli,L., Llovera,R.E., Mathov,I., Lue,L.F., Frangione,B., Ghiso,J. and Castano,E.M.
    Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy
    J Biol Chem279, 56004-56013. PubMed  Europe PubMed DOI
  234. Roth,R.A.
    Insulysin
    [ISSN:0-12-079610-4]2, 871-876.  V
  235. [YEAR:15-2-2004]Sakai,A., Ujike,H., Nakata,K., Takehisa,Y., Imamura,T., Uchida,N., Kanzaki,A., Yamamoto,M., Fujisawa,Y., Okumura,K. and Kuroda,S.
    No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population
    Am J Med Genet B Neuropsychiatr Genet125B, 87-91. PubMed  Europe PubMed DOI  M
  236. [YEAR:19-11-2004]Song,E.S., Juliano,M.A., Juliano,L., Fried,M.G., Wagner,S.L. and Hersh,L.B.
    ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety
    J Biol Chem279, 54216-54220. PubMed  Europe PubMed DOI  A
  237. [YEAR:8-12-2004]Zhao,L., Teter,B., Morihara,T., Lim,G.P., Ambegaokar,S.S., Ubeda,O.J., Frautschy,S.A. and Cole,G.M.
    Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention
    J Neurosci24, 11120-11126. PubMed  Europe PubMed DOI
    238. 2003
  238. Bennett,R.G., Fawcett,J., Kruer,M.C., Duckworth,W.C. and Hamel,F.G.
    Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme
    J Endocrinol177, 399-405. PubMed  Europe PubMed DOI
  239. Cook,D.G., Leverenz,J.B., McMillan,P.J., Kulstad,J.J., Ericksen,S., Roth,R.A., Schellenberg,G.D., Jin,L.W., Kovacina,K.S. and Craft,S.
    Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
    Am J Pathol162, 313-319. PubMed  Europe PubMed
  240. [YEAR:10-7-2003]Edland,S.D., Wavrant-De Vriese,F., Compton,D., Smith,G.E., Ivnik,R., Boeve,B.F., Tangalos,E.G. and Petersen,R.C.
    Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE)
    Neurosci Lett345, 21-24. PubMed  Europe PubMed DOI  M
  241. [YEAR:1-4-2003]Farris,W., Mansourian,S., Chang,Y., Lindsley,L., Eckman,E.A., Frosch,M.P., Eckman,C.B., Tanzi,R.E., Selkoe,D.J. and Guenette,S.
    Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
    Proc Natl Acad Sci U S A100, 4162-4167. PubMed  Europe PubMed DOI  K
  242. Groves,C.J., Wiltshire,S., Smedley,D., Owen,K.R., Frayling,T.M., Walker,M., Hitman,G.A., Levy,J.C., O'Rahilly,S., Menzel,S., Hattersley,A.T. and McCarthy,M.I.
    Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility
    Diabetes52, 1300-1305. PubMed  Europe PubMed DOI
  243. Hamel,F.G., Upward,J.L. and Bennett,R.G.
    In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters
    Endocrinology144, 2404-2408. PubMed  Europe PubMed DOI
  244. Karamohamed,S., Demissie,S., Volcjak,J., Liu,C., Heard-Costa,N., Liu,J., Shoemaker,C.M., Panhuysen,C.I., Meigs,J.B., Wilson,P., Atwood,L.D., Cupples,L.A. and Herbert,A.
    Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study
    Diabetes52, 1562-1567. PubMed  Europe PubMed DOI  M
  245. [YEAR:13-5-2003]Miller,B.C., Eckman,E.A., Sambamurti,K., Dobbs,N., Chow,K.M., Eckman,C.B., Hersh,L.B. and Thiele,D.L.
    Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo
    Proc Natl Acad Sci U S A100, 6221-6226. PubMed  Europe PubMed DOI  K
  246. [YEAR:30-6-2003]Saric,T., Muller,D., Seitz,H.J. and Pavelic,K.
    Non-covalent interaction of ubiquitin with insulin-degrading enzyme
    Mol Cell Endocrinol204, 11-20. PubMed  Europe PubMed DOI
    247. 2002
  247. [YEAR:23-8-2002]Boussaha,M., Hannequin,D., Verpillat,P., Brice,A., Frebourg,T. and Campion,D.
    Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease
    Neurosci Lett329, 121-123. PubMed  Europe PubMed DOI  M
  248. [YEAR:19-4-2002]Edbauer,D., Willem,M., Lammich,S., Steiner,H. and Haass,C.
    Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)
    J Biol Chem277, 13389-13393. PubMed  Europe PubMed DOI
    249. 2001
  249. Abraham,R., Myers,A., Wavrant-DeVrieze,F., Hamshere,M.L., Thomas,H.V., Marshall,H., Compton,D., Spurlock,G., Turic,D., Hoogendoorn,B., Kwon,J.M., Petersen,R.C., Tangalos,E., Norton,J., Morris,J.C., Bullock,R., Liolitsa,D., Lovestone,S., Hardy,J., Goate,A., O'Donovan,M., Williams,J., Owen,M.J. and Jones,L.
    Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
    Hum Genet109, 646-652. PubMed  Europe PubMed DOI  M
  250. Camberos,M.C., rez,A.A., Udrisar,D.P., Wanderley,M.I. and Cresto,J.C.
    ATP inhibits insulin-degrading enzyme activity
    Exp Biol Med (Maywood)226, 334-341. PubMed  Europe PubMed
  251. Kurochkin,I.V.
    Insulin-degrading enzyme: embarking on amyloid destruction
    Trends Biochem Sci26, 421-425. PubMed  Europe PubMed DOI
  252. [YEAR:12-1-2001]Song,E.S., Mukherjee,A., Juliano,M.A., Pyrek,J.S., Goodman,J.P., Jr., Juliano,L. and Hersh,L.B.
    Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates
    J Biol Chem276, 1152-1155. PubMed  Europe PubMed DOI
    253. 2000
  253. [YEAR:24-11-2000]Bennett,R.G., Duckworth,W.C. and Hamel,F.G.
    Degradation of amylin by insulin-degrading enzyme
    J Biol Chem275, 36621-36625. PubMed  Europe PubMed DOI
  254. [YEAR:15-10-2000]Chesneau,V., Vekrellis,K., Rosner,M.R. and Selkoe,D.J.
    Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization
    Biochem J351, 509-516. PubMed  Europe PubMed DOI
  255. Chesneau,V. and Rosner,M.R.
    Functional human insulin-degrading enzyme can be expressed in bacteria
    Protein Expr Purif19, 91-98. PubMed  Europe PubMed DOI  E
  256. [YEAR:1-9-2000]Fakhrai-Rad,H., Nikoshkov,A., Kamel,A., Fernstrom,M., Zierath,J.R., Norgren,S., Luthman,H. and Galli,J.
    Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
    Hum Mol Genet9, 2149-2158. PubMed  Europe PubMed
  257. Morita,M., Kurochkin,I.V., Motojima,K., Goto,S., Takano,T., Okamura,S., Sato,R., Yokota,S. and Imanaka,T.
    Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins
    Cell Struct Funct25, 309-315. PubMed  Europe PubMed DOI
  258. [YEAR:1-12-2000]Mukherjee,A., Song,E., Kihiko-Ehmann,M., Goodman,J.P., Jr., St Pyrek,J., Estus,S. and Hersh,L.B.
    Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques
    J Neurosci20, 8745-8749. PubMed  Europe PubMed
  259. Perez,A., Morelli,L., Cresto,J.C. and Castano,E.M.
    Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
    Neurochem Res25, 247-255. PubMed  Europe PubMed DOI
  260. [YEAR:1-3-2000]Vekrellis,K., Ye,Z., Qiu,W.Q., Walsh,D., Hartley,D., Chesneau,V., Rosner,M.R. and Selkoe,D.J.
    Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
    J Neurosci20, 1657-1665. PubMed  Europe PubMed
    261. 1998
  261. Duckworth,W.C., Bennett,R.G. and Hamel,F.G.
    Insulin degradation: progress and potential
    Endocr Rev19, 608-624. PubMed  Europe PubMed DOI
  262. [YEAR:17-3-1998]Duckworth,W.C., Bennett,R.G. and Hamel,F.G.
    Insulin acts intracellularly on proteasomes through insulin-degrading enzyme
    Biochem Biophys Res Commun244, 390-394. PubMed  Europe PubMed DOI
  263. Hamel,F.G., Bennett,R.G. and Duckworth,W.C.
    Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme
    Endocrinology139, 4061-4066. PubMed  Europe PubMed DOI
  264. [YEAR:4-12-1998]Qiu,W.Q., Walsh,D.M., Ye,Z., Vekrellis,K., Zhang,J., Podlisny,M.B., Rosner,M.R., Safavi,A., Hersh,L.B. and Selkoe,D.J.
    Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
    J Biol Chem273, 32730-32738. PubMed  Europe PubMed DOI
  265. [YEAR:1-5-1998]Sarada,B., Thiele,D., Dang,T., Lee,J., Safavia,A., Hersh,L.B. and Cottam,G.L.
    Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular beta-endorphin endopeptidase (IDE/gamma-EpGE)
    J Neuroimmunol85, 59-68. PubMed  Europe PubMed DOI
    266. 1997
  266. Bennett,R.G., Hamel,F.G. and Duckworth,W.C.
    Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex
    Diabetes46, 197-203. PubMed  Europe PubMed
  267. Chesneau,V., Perlman,R.K., Li,W., Keller,G.A. and Rosner,M.R.
    Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation
    Endocrinology138, 3444-3451. PubMed  Europe PubMed DOI
  268. Hamel,F.G., Gehm,B.D., Rosner,M.R. and Duckworth,W.C.
    Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes
    Biochim Biophys Acta1338, 207-214. PubMed  Europe PubMed DOI
  269. Shearer,J.D., Coulter,C.F., Engeland,W.C., Roth,R.A. and Caldwell,M.D.
    Insulin is degraded extracellularly in wounds by insulin-degrading enzyme (EC 3.4.24.56)
    Am J Physiol273, E657-E664. PubMed  Europe PubMed
    270. 1996
  270. Authier,F., Posner,B.I. and Bergeron,J.J.
    Insulin-degrading enzyme
    Clin Invest Med19, 149-160. PubMed  Europe PubMed
  271. Authier,F., Cameron,P.H. and Taupin,V.
    Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells
    Biochem J319, 149-158. PubMed  Europe PubMed
  272. Safavi,A., Miller,B.C., Cottam,L. and Hersh,L.B.
    Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme
    Biochemistry35, 14318-14325. PubMed  Europe PubMed DOI
    273. 1995
  273. Becker,A.B. and Roth,R.A.
    Insulysin and pitrilysin: insulin-degrading enzymes of mammals and bacteria
    Methods Enzymol248, 693-703. PubMed  Europe PubMed DOI  V
    274. 1994
  274. Kuo,W.L., Gehm,B.D., Rosner,M.R., Li,W. and Keller,G.
    Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line
    J Biol Chem269, 22599-22606. PubMed  Europe PubMed
  275. [YEAR:23-5-1994]Kurochkin,I.V. and Goto,S.
    Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
    FEBS Lett345, 33-37. PubMed  Europe PubMed DOI
  276. Perlman,R.K. and Rosner,M.R.
    Identification of zinc ligands of the insulin-degrading enzyme
    J Biol Chem269, 33140-33145. PubMed  Europe PubMed
  277. Saric,T., Seitz,H.J. and Pavelic,K.
    Detection of the substance immunologically cross-reactive with insulin in insulin RIA is an artifact caused by insulin tracer degradation: Involvement of the insulin-degrading enzyme
    Mol Cell Endocrinol106, 23-29. PubMed  Europe PubMed DOI
    278. 1993
  278. [YEAR:15-2-1993]Baumeister,H., Muller,D., Rehbein,M. and Richter,D.
    The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts
    FEBS Lett317, 250-254. PubMed  Europe PubMed DOI
  279. Gehm,B.D., Kuo,W.L., Perlman,R.K. and Rosner,M.R.
    Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding
    J Biol Chem268, 7943-7948. PubMed  Europe PubMed
  280. Kuo,W.L., Montag,A.G. and Rosner,M.R.
    Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues
    Endocrinology132, 604-611. PubMed  Europe PubMed DOI
  281. Perlman,R.K., Gehm,B.D., Kuo,W.L. and Rosner,M.R.
    Functional analysis of conserved residues in the active site of insulin-degrading enzyme
    J Biol Chem268, 21538-21544. PubMed  Europe PubMed
    282. 1992
  282. [YEAR:1-1-1992]Carvalho,K.M., Joudiou,C., Boussetta,H., Leseney,A.M. and Cohen,P.
    A peptide-hormone-inactivating endopeptidase in Xenopus laevis skin secretion
    Proc Natl Acad Sci U S A89, 84-88. PubMed  Europe PubMed
  283. Ding,L., Becker,A.B., Suzuki,A. and Roth,R.A.
    Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III
    J Biol Chem267, 2414-2420. PubMed  Europe PubMed
  284. Muller,D., Schulze,C., Baumeister,H., Buck,F. and Richter,D.
    Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry
    Biochemistry31, 11138-11143. PubMed  Europe PubMed DOI
  285. Ogawa,W., Shii,K., Yonezawa,K., Baba,S. and Yokono,K.
    Affinity purification of insulin-degrading enzyme and its endogenous inhibitor from rat liver
    J Biol Chem267, 1310-1316. PubMed  Europe PubMed
    286. 1991
  286. Rawlings,N.D. and Barrett,A.J.
    Homologues of insulinase, a new superfamily of metalloendopeptidases
    Biochem J275, 389-391. PubMed  Europe PubMed
    287. 1990
  287. Affholter,J.A., Hsieh,C.L., Francke,U. and Roth,R.A.
    Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes
    Mol Endocrinol4, 1125-1135. PubMed  Europe PubMed DOI
  288. Duckworth,W.C., Hamel,F.G., Bennett,R., Ryan,M.P. and Roth,R.A.
    Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin
    J Biol Chem265, 2984-2987. PubMed  Europe PubMed
  289. Kuo,W.L., Gehm,B.D. and Rosner,M.R.
    Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme
    Mol Endocrinol4, 1580-1591. PubMed  Europe PubMed DOI
    290. 1988
  290. Affholter,J.A., Fried,V.A. and Roth,R.A.
    Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III
    Science242, 1415-1418. PubMed  Europe PubMed
  291. Duckworth,W.C.
    Insulin degradation: mechanisms, products, and significance
    Endocr Rev9, 319-345. PubMed  Europe PubMed DOI
  292. Garcia,J.V., Fenton,B.W. and Rosner,M.R.
    Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster
    Biochemistry27, 4237-4244. PubMed  Europe PubMed
    293. 1986
  293. Shii,K. and Roth,R.A.
    Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease
    Proc Natl Acad Sci U S A83, 4147-4151. PubMed  Europe PubMed
    294. 1985
  294. Shii,K., Baba,S., Yokono,K. and Roth,R.A.
    Covalent linkage of 125I-insulin to a cytosolic insulin-degrading enzyme
    J Biol Chem260, 6503-6506. PubMed  Europe PubMed
    295. 1959
  295. Tomizawa,H.H. and Halsey,Y.D.
    Isolation of an insulin-degrading enzyme from beef liver
    J Biol Chem234, 307-310. PubMed  Europe PubMed
    296. 1957
  296. Mirsky,I.A. and Perisutti,G.
    Insulinase-inhibitory activity of protein hydrolysates
    Proc Soc Exp Biol Med94, 589-592. PubMed  Europe PubMed DOI  I
    297. 1955
  297. Beyer,R.E.
    A study of insulin metabolism in an insulin tolerant strain of mice
    Acta Endocrinol (Copenh)19, 309-332. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use