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Literature for peptidase M16.002: insulysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bertocci,B., Yilmaz,A., Waeckel-Enee,E., Guerrera,C., Roger,K., Toure,L. and van Endert,P.M.
    Insulin-Degrading Enzyme Regulates mRNA Processing and May Interact with the CCR4-NOT Complex
    Cells (2025) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  2. Mancl,J.M., Liang,W.G., Bayhi,N.L., Wei,H., Carragher,B., Potter,C.S. and Tang,W.J.
    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Bessard,M.A., Moser,A., Waeckel-Enee,E., Lindo,V., Gdoura,A., You,S., Wong,F.S., Greer,F. and van Endert,P.
    Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes
    Front Immunol (2024) 15, 1474453-1474453. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Geijtenbeek,K.W., Aranda,A.S., Sanz,A.S., Janzen,J., Bury,A.E., Kors,S., Al Amery,N., Schmitz,N.C.M., Reits,E.A.J. and Schipper-Krom,S.
    Insulin-Degrading Enzyme Efficiently Degrades polyQ Peptides but not Expanded polyQ Huntingtin Fragments
    J Huntingtons Dis (2024) 13, 201-214. PubMed  Europe PubMed DOI
  5. Issac,L., Dolev,D., Irit,B., Assaf,D. and Levy,I.
    Assessment of insulin-degrading enzyme inhibitor for the treatment of corneal erosion in a rat model
    Graefes Arch Clin Exp Ophthalmol (2024) PubMed  Europe PubMed DOI  I
  6. Metwally,H.M., Younis,N.M., Abdel-Latif,E. and El-Rayyes,A.
    New thiazole, thiophene and 2-pyridone compounds incorporating dimethylaniline moiety: synthesis, cytotoxicity, ADME and molecular docking studies
    BMC Chem (2024) 18, 52-52. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Yuan,T., Wang,H., Wang,Y., Dong,S., Ge,J., Li,Z. and Sun,S.
    Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head
    Mol Med (2024) 30, 111-111. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Zukowska,J., Moss,S.J., Subramanian,V. and Acharya,K.R.
    Molecular basis of selective amyloid-beta degrading enzymes in Alzheimer's disease
    FEBS J (2024) 291, 2999-3029. PubMed  Europe PubMed DOI  V
    9. 2023
  9. Ambrozova,L., Zeman,T., Janout,V., Janoutova,J., Lochman,J. and Sery,O.
    Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report
    J Clin Lab Anal (2023) 37, e24949-e24949. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Corraliza-Gomez,M., Bermejo,T., Lilue,J., Rodriguez-Iglesias,N., Valero,J., Cozar-Castellano,I., Arranz,E., Sanchez,D. and Ganfornina,M.D.
    Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging
    J Neuroinflammation (2023) 20, 233-233. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Rao,F., Zhang,Z. and Li,J.
    Dynamical analysis of a glucose-insulin regulatory system with insulin-degrading enzyme and multiple delays
    J Math Biol (2023) 87, 73-73. PubMed  Europe PubMed DOI
  12. Rowland,H.A., Moxon,S.R., Corbett,N.J., Hanson,K., Fisher,K., Kellett,K.A.B. and Hooper,N.M.
    Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-beta deposition
    Neuronal Signal (2023) 7, NS20230016-NS20230016. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Tian,Y., Jing,G. and Zhang,M.
    Insulin-degrading enzyme: Roles and pathways in ameliorating cognitive impairment associated with Alzheimer's disease and diabetes
    Ageing Res Rev (2023) 90, 101999-101999. PubMed  Europe PubMed DOI  V
  14. Tundo,G.R., Grasso,G., Persico,M., Tkachuk,O., Bellia,F., Bocedi,A., Marini,S., Parravano,M., Graziani,G., Fattorusso,C. and Sbardella,D.
    The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design
    Biomolecules (2023) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  15. Yilmaz,A., Guerrera,C., Waeckel-Enee,E., Lipecka,J., Bertocci,B. and van Endert,P.
    Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins
    Biomolecules (2023) 13 PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2022
  16. Azam,M.S., Wahiduzzaman,M., Reyad-Ul-Ferdous,M., Islam,M.N. and Roy,M.
    Inhibition of Insulin Degrading Enzyme to Control Diabetes Mellitus and its Applications on some Other Chronic Disease: a Critical Review
    Pharm Res (2022) 39, 611-629. PubMed  Europe PubMed DOI  V
  17. Corraliza-Gomez,M., Lillo,C., Cozar-Castellano,I., Arranz,E., Sanchez,D. and Ganfornina,M.D.
    Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells
    Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  18. Distefano,A., Caruso,G., Oliveri,V., Bellia,F., Sbardella,D., Zingale,G.A., Caraci,F. and Grasso,G.
    Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
    ACS Chem Neurosci (2022) 13, 1588-1593. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Distefano,A., Antonio Zingale,G. and Grasso,G.
    An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme
    Anal Bioanal Chem (2022) 414, 4793-4802. PubMed  Europe PubMed DOI
  20. Lesire,L., Leroux,F., Deprez-Poulain,R. and Deprez,B.
    Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?
    Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
  21. Martin-Martin,Y., Perez-Garcia,A., Torrecilla-Parra,M., Fernandez-de Frutos,M., Pardo-Marques,V., Casarejos,M.J., Busto,R. and Ramirez,C.M.
    New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs
    Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  22. Pablos,M., Casanueva-Alvarez,E., Gonzalez-Casimiro,C.M., Merino,B., Perdomo,G. and Cozar-Castellano,I.
    Primary Cilia in Pancreatic beta- and alpha-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
    Front Endocrinol (Lausanne) (2022) 13, 922825-922825. PubMed  Europe PubMed DOI  PMC  EPMC  V
  23. Tundo,G.R., Sbardella,D., Oddone,F., Grasso,G., Marini,S., Atzori,M.G., Santoro,A.M., Milardi,D., Bellia,F., Macari,G., Graziani,G., Polticelli,F., Cascio,P., Parravano,M. and Coletta,M.
    Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug
    Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC  K  I
    24. 2021
  24. Adamek,R.N., Suire,C.N., Stokes,R.W., Brizuela,M.K., Cohen,S.M. and Leissring,M.A.
    Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme
    ChemMedChem (2021) PubMed  Europe PubMed DOI  I
  25. Hostachy,S., Utesch,T., Franke,K., Dornan,G.L., Furkert,D., Turkaydin,B., Haucke,V., Sun,H. and Fiedler,D.
    Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs
    Chem Sci (2021) 12, 10696-10702. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Inoue,Y., Masuda,T., Misumi,Y., Ando,Y. and Ueda,M.
    Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus
    Neurosci Lett (2021) 762, 136136-136136. PubMed  Europe PubMed DOI
  27. Leissring,M.A., Gonzalez-Casimiro,C.M., Merino,B., Suire,C.N. and Perdomo,G.
    Targeting Insulin-Degrading Enzyme in Insulin Clearance
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC  V
  28. Leissring,M.A.
    Insulin-Degrading Enzyme: Paradoxes and Possibilities
    Cells (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  29. Li,C., Wang,Y., Zhu,G., Shang,Y., Jiefang,K. and Li,J.
    IL-6 induced enhanced clearance of proANP and ANP by insulin-degrading enzyme in T1DM mouse
    Biochem Cell Biol (2021) PubMed  Europe PubMed DOI
  30. Nash,Y., Ganoth,A., Borenstein-Auerbach,N., Levy-Barazany,H., Goldsmith,G., Kopelevich,A., Pozyuchenko,K., Sakhneny,L., Lazdon,E., Blanga-Kanfi,S., Alhadeff,R., Benromano,T., Landsman,L., Tsfadia,Y. and Frenkel,D.
    From virus to diabetes therapy: Characterization of a specific insulin-degrading enzyme inhibitor for diabetes treatment
    FASEB J (2021) 35, e21374-e21374. PubMed  Europe PubMed DOI  I
  31. Ramaraju,B., Nelson,S.L., Zheng,W., Ghirlando,R. and Deshmukh,L.
    Quantitative NMR Study of Insulin-Degrading Enzyme Using Amyloid-beta and HIV-1 p6 Elucidates Its Chaperone Activity
    Biochemistry (2021) PubMed  Europe PubMed DOI
  32. Sousa,L., Guarda,M., Meneses,M.J., Macedo,M.P. and Vicente Miranda,H.
    Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases
    J Pathol (2021) PubMed  Europe PubMed DOI  V
  33. Waclawczyk,D., Silberring,J. and Grasso,G.
    The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism
    J Enzyme Inhib Med Chem (2021) 36, 183-187. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Zheng,Q., Kebede,M.T., Lee,B., Krasinski,C.A., Islam,S., Wurfl,L.A., Kemeh,M.M., Ivancic,V.A., Jakobsche,C.E., Spratt,D.E. and Lazo,N.D.
    Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme
    Antioxidants (Basel) (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC  I
    35. 2020
  35. Bernstein,H.G., Keilhoff,G., Dobrowolny,H. and Steiner,J.
    Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme's implication for Alzheimer s disease pathology?
    Eur Arch Psychiatry Clin Neurosci (2020) 270, 495-496. PubMed  Europe PubMed DOI
  36. Fu,H., Liu,B., Li,L. and Lemere,C.A.
    Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme
    Neuroscience (2020) 443, 30-43. PubMed  Europe PubMed DOI
  37. Kim,N. and Lee,H.J.
    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
    Biomed Res Int (2020) 2020, 2010728-2010728. PubMed  Europe PubMed DOI  PMC  EPMC  V
  38. Lauer,A.A., Mett,J., Janitschke,D., Thiel,A., Stahlmann,C.P., Bachmann,C.M., Ritzmann,F., Schrul,B., Muller,U.C., Stein,R., Riemenschneider,M., Grimm,H.S., Hartmann,T. and Grimm,M.O.W.
    Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease
    Aging Cell (2020) , e13264-e13264. PubMed  Europe PubMed DOI
  39. Merino,B., Fernandez-Diaz,C.M., Parrado-Fernandez,C., Gonzalez-Casimiro,C.M., Postigo-Casado,T., Lobaton,C.D., Leissring,M.A., Cozar-Castellano,I. and Perdomo,G.
    Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice
    Metabolism (2020) 113, 154352-154352. PubMed  Europe PubMed DOI
  40. Minchenko,D.O., Khita,O.O., Tsymbal,D.O., Danilovskyi,S.V., Rudnytska,O.V., Halkin,O.V., Kryvdiuk,I.V., Smeshkova,M.V., Yakymchuk,M.M., Bezrodnyi,B.H. and Minchenko,O.H.
    Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation
    Endocr Regul (2020) 54, 183-195. PubMed  Europe PubMed DOI
  41. Suire,C.N., Brizuela,M.K. and Leissring,M.A.
    Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin
    Methods Protoc (2020) 3 PubMed  Europe PubMed DOI  PMC  EPMC
    42. 2019
  42. Bellia,F., Lanza,V., Ahmed,I.M.M., Garcia-Vinuales,S., Veiss,E., Arizzi,M., Calcagno,D., Milardi,D. and Grasso,G.
    Site directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus E1-like activity: the role of metal ions
    Metallomics (2019) 11, 278-281. PubMed  Europe PubMed DOI
  43. Borges,D.O., Meneses,M.J., Dias,T.R., Martins,F.O., Oliveira,P.F., Alves,M.G. and Macedo,M.P.
    Data on metabolic profile of insulin-degrading enzyme knockout mice
    Data Brief (2019) 25, 104023-104023. PubMed  Europe PubMed DOI  PMC  EPMC  K
  44. Fernandez-Diaz,C.M., Merino,B., Lopez-Acosta,J.F., Cidad,P., de la Fuente,M.A., Lobaton,C.D., Moreno,A., Leissring,M.A., Perdomo,G. and Cozar-Castellano,I.
    Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity
    Am J Physiol Endocrinol Metab (2019) 317, E805-E805. PubMed  Europe PubMed DOI  K
  45. Leng,Q.Y., Zheng,J.H., Xu,H.D., Adu-Asiamah,P., Zhang,Y., Du,B.W. and Zhang,L.
    [Cloning and expression analysis of chicken circular transcript of insulin degrading enzyme gene]
    Yi Chuan (2019) 41, 1129-1137. PubMed  Europe PubMed DOI
  46. Leroux,F., Bosc,D., Beghyn,T., Hermant,P., Warenghem,S., Landry,V., Pottiez,V., Guillaume,V., Charton,J., Herledan,A., Urata,S., Liang,W., Sheng,L., Tang,W.J., Deprez,B. and Deprez-Poulain,R.
    Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening
    Eur J Med Chem (2019) 179, 557-566. PubMed  Europe PubMed DOI  I
  47. Maianti,J.P., Tan,G.A., Vetere,A., Welsh,A.J., Wagner,B.K., Seeliger,M.A. and Liu,D.R.
    Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme
    Nat Chem Biol (2019) 15, 565-574. PubMed  Europe PubMed DOI  S  I
  48. Meneses,M.J., Borges,D.O., Dias,T.R., Martins,F.O., Oliveira,P.F., Macedo,M.P. and Alves,M.G.
    Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality
    Mol Cell Endocrinol (2019) 486, 11-17. PubMed  Europe PubMed DOI  K
  49. Zhang,S., Chen,L., Li,F., Li,N., Feng,Y. and Xiao,L.
    Divergent copies of a Cryptosporidium parvum-specific subtelomeric gene
    Microorganisms (2019) 7 PubMed  Europe PubMed DOI
    50. 2018
  50. Grasso,G.
    Commentary on Ivancic et al.: Enzyme Kinetics from Circular Dichroism of Insulin Reveals Mechanistic Insights into the Regulation of Insulin-degrading Enzyme
    Biosci Rep (2018) 38, BSR20181555-BSR20181555. PubMed  Europe PubMed DOI
  51. Hayrabedyan,S., Todorova,K., Spinelli,M., Barnea,E.R. and Mueller,M.
    The core sequence of PIF competes for insulin/amyloid beta in insulin degrading enzyme: potential treatment for Alzheimer's disease
    Oncotarget (2018) 9, 33884-33895. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Ivancic,V.A., Krasinski,C.A., Zheng,Q., Meservier,R.J., Spratt,D.E. and Lazo,N.D.
    Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme
    Biosci Rep (2018) 38, BSR20181416-BSR20181416. PubMed  Europe PubMed DOI
  53. Krasinski,C.A., Ivancic,V.A., Zheng,Q., Spratt,D.E. and Lazo,N.D.
    Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Abeta42
    ACS Omega (2018) 3, 13275-13282. PubMed  Europe PubMed DOI  PMC  EPMC  I
  54. Krasinski,C.A., Zheng,Q., Ivancic,V.A., Spratt,D.E. and Lazo,N.D.
    The longest amyloid-beta precursor protein intracellular domain produced with Abeta42 forms beta-sheet-containing monomers that self-assemble and are proteolyzed by insulin-degrading enzyme
    ACS Chem Neurosci (2018) 9, 2892-2897. PubMed  Europe PubMed DOI
  55. Kurochkin,I.V., Guarnera,E. and Berezovsky,I.N.
    Insulin-degrading enzyme in the fight against Alzheimer's disease
    Trends Pharmacol Sci (2018) 39, 49-58. PubMed  Europe PubMed DOI
  56. Lai,R., Tang,W.J. and Li,H.
    Catalytic mechanism of amyloid-beta peptide degradation by insulin degrading enzyme: insights from quantum mechanics and molecular mechanics style Moller-Plesset second order perturbation theory calculation
    J Chem Inf Model (2018) 58, 1926-1934. PubMed  Europe PubMed DOI
  57. Stefanidis,L., Fusco,N.D., Cooper,S.E., Smith-Carpenter,J.E. and Alper,B.J.
    Molecular determinants of substrate specificity in human insulin-degrading enzyme
    Biochemistry (2018) 57, 4903-4914. PubMed  Europe PubMed DOI
  58. Suire,C.N., Nainar,S., Fazio,M., Kreutzer,A.G., Paymozd-Yazdi,T., Topper,C.L., Thompson,C.R. and Leissring,M.A.
    Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display
    PLoS ONE (2018) 13, e0193101-e0193101. PubMed  Europe PubMed DOI  I
  59. Villa-Perez,P., Merino,B., Fernandez-Diaz,C.M., Cidad,P., Lobaton,C.D., Moreno,A., Muturi,H.T., Ghadieh,H.E., Najjar,S.M., Leissring,M.A., Cozar-Castellano,I. and Perdomo,G.
    Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice
    Metabolism (2018) 88, 1-11. PubMed  Europe PubMed DOI  K
  60. Yang,D., Qin,W., Shi,X., Zhu,B., Xie,M., Zhao,H., Teng,B., Wu,Y., Zhao,R., Yin,F., Ren,P., Liu,L. and Li,Z.
    Stabilized beta-hairpin peptide inhibits insulin degrading enzyme
    J Med Chem (2018) 61, 8174-8185. PubMed  Europe PubMed DOI  I
  61. Zhang,Y. and Wang,P.
    Age-related increase of insulin-degrading enzyme is inversely correlated with cognitive function in APPswe/PS1dE9 mice
    Med Sci Monit (2018) 24, 2446-2455. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Zhang,Z., Liang,W.G., Bailey,L.J., Tan,Y.Z., Wei,H., Wang,A., Farcasanu,M., Woods,V.A., McCord,L.A., Lee,D., Shang,W., Deprez-Poulain,R., Deprez,B., Liu,D.R., Koide,A., Koide,S., Kossiakoff,A.A., Li,S., Carragher,B., Potter,C.S. and Tang,W.J.
    Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
    elife (2018) 7 PubMed  Europe PubMed DOI  S
    63. 2017
  63. Hahn,F., Schmalen,A., Setz,C., Friedrich,M., Schlosser,S., Kolle,J., Spranger,R., Rauch,P., Fraedrich,K., Reif,T., Karius-Fischer,J., Balasubramanyam,A., Henklein,P., Fossen,T. and Schubert,U.
    Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner
    PLoS ONE (2017) 12, e0174254-e0174254. PubMed  Europe PubMed DOI
  64. Jamal,S., Goyal,S., Shanker,A. and Grover,A.
    Machine learning and molecular dynamics based insights into mode of actions of insulin degrading enzyme modulators
    Comb Chem High Throughput Screen (2017) 20, 279-291. PubMed  Europe PubMed
  65. Kurochkin,I.V., Guarnera,E., Wong,J.H., Eisenhaber,F. and Berezovsky,I.N.
    Toward allosterically increased catalytic activity of insulin-degrading enzyme against amyloid peptides
    Biochemistry (2017) 56, 228-239. PubMed  Europe PubMed DOI
  66. Li,H., Wu,J., Zhu,L., Sha,L., Yang,S., Wei,J., Ji,L., Tang,X., Mao,K., Cao,L., Wei,N., Xie,W. and Yang,Z.
    Insulin degrading enzyme contributes to the pathology in a mixed model of type 2 diabetes and Alzheimer's disease
    Biosci Rep (2017) 38, BSR20170862-BSR20170862. PubMed  Europe PubMed DOI
  67. Song,E.S., Jang,H., Guo,H.F., Juliano,M.A., Juliano,L., Morris,A.J., Galperin,E., Rodgers,D.W. and Hersh,L.B.
    Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes
    Proc Natl Acad Sci U S A (2017) 114, E2826-E2835. PubMed  Europe PubMed DOI
  68. Tundo,G.R., Sbardella,D., Ciaccio,C., Grasso,G., Gioia,M., Coletta,A., Polticelli,F., Di Pierro,D., Milardi,D., van Endert,P., Marini,S. and Coletta,M.
    Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
    Crit Rev Biochem Mol Biol (2017) 52, 554-582. PubMed  Europe PubMed DOI
    69. 2016
  69. Cai,P., Zhong,W., Jia,M., Yu,C., Peng,Y., Wang,Y., Wang,H., Zeng,C., Bai,Y. and Wang,X.
    The gene polymorphisms of insulin degrading enzyme (IDE) are associated with the risk of coronary heart disease in Chinese Han population
    Int J Clin Exp Pathol (2016) 9, 5544-5551.  M
  70. Grimm,M.O., Mett,J., Stahlmann,C.P., Haupenthal,V.J., Blumel,T., Stotzel,H., Grimm,H.S. and Hartmann,T.
    Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-beta by affecting insulin-degrading enzyme
    Biochem Cell Biol (2016) 94, 534-542. PubMed  Europe PubMed DOI
  71. Hogan,M.F., Meier,D.T., Zraika,S., Templin,A.T., Mellati,M., Hull,R.L., Leissring,M.A. and Kahn,S.E.
    Inhibition of insulin-degrading enzyme does not increase islet amyloid deposition in vitro
    Endocrinology (2016) 157, 3462-3468. PubMed  Europe PubMed DOI  I
  72. Hubin,E., Cioffi,F., Rozenski,J., Van Nuland,N.A. and Broersen,K.
    Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation states
    Biochim Biophys Acta (2016) 1860, 1281-1290. PubMed  Europe PubMed DOI  P
  73. Lukman,S.
    Novel druggable sites of insulin-degrading enzyme identified through applied structural bioinformatics analysis
    Procedia Comput Sci (2016) 80, 2292-2296. DOI  I
  74. Paul,T.J., Barman,A., Ozbil,M., Bora,R.P., Zhang,T., Sharma,G., Hoffmann,Z. and Prabhakar,R.
    Mechanisms of peptide hydrolysis by aspartyl and metalloproteases
    Phys Chem Chem Phys (2016) 18, 24790-24801. PubMed  Europe PubMed DOI
  75. Pivovarova,O., Hohn,A., Grune,T., Pfeiffer,A.F. and Rudovich,N.
    Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?
    Ann Med (2016) 48, 614-624. PubMed  Europe PubMed DOI  T  I
  76. Son,S.M., Cha,M.Y., Choi,H., Kang,S., Choi,H., Lee,M.S., Park,S.A. and Mook-Jung,I.
    Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease
    Autophagy (2016) 12, 784-800. PubMed  Europe PubMed DOI
  77. Tang,W.J.
    Targeting insulin-degrading enzyme to treat type 2 diabetes mellitus
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