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Literature for peptidase M16.002: insulysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Ambrozova,L., Zeman,T., Janout,V., Janoutova,J., Lochman,J. and Sery,O. \<br\>Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report\<br\>J Clin Lab Anal (2023) 37, e24949. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Corraliza-Gomez,M., Bermejo,T., Lilue,J., Rodriguez-Iglesias,N., Valero,J., Cozar-Castellano,I., Arranz,E., Sanchez,D. and Ganfornina,M.D. \<br\>Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging\<br\>J Neuroinflammation (2023) 20, 233. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Rao,F., Zhang,Z. and Li,J. \<br\>Dynamical analysis of a glucose-insulin regulatory system with insulin-degrading enzyme and multiple delays\<br\>J Math Biol (2023) 87, 73. PubMed  Europe PubMed DOI
  4. Rowland,H.A., Moxon,S.R., Corbett,N.J., Hanson,K., Fisher,K., Kellett,K.A.B. and Hooper,N.M. \<br\>Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-beta deposition\<br\>Neuronal Signal (2023) 7, NS20230016. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Tundo,G.R., Grasso,G., Persico,M., Tkachuk,O., Bellia,F., Bocedi,A., Marini,S., Parravano,M., Graziani,G., Fattorusso,C. and Sbardella,D. \<br\>The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design\<br\>Biomolecules (2023) 13, PubMed  Europe PubMed DOI  PMC  EPMC
  6. Yilmaz,A., Guerrera,C., Waeckel-Enee,E., Lipecka,J., Bertocci,B. and van Endert,P. \<br\>Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins\<br\>Biomolecules (2023) 13, PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Azam,M.S., Wahiduzzaman,M., Reyad-Ul-Ferdous,M., Islam,M.N. and Roy,M. \<br\>Inhibition of Insulin Degrading Enzyme to Control Diabetes Mellitus and its Applications on some Other Chronic Disease: a Critical Review\<br\>Pharm Res (2022) 39, 611-629. PubMed  Europe PubMed DOI  V
  8. Corraliza-Gomez,M., Lillo,C., Cozar-Castellano,I., Arranz,E., Sanchez,D. and Ganfornina,M.D. \<br\>Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells\<br\>Cells (2022) 11, PubMed  Europe PubMed DOI  PMC  EPMC
  9. Distefano,A., Caruso,G., Oliveri,V., Bellia,F., Sbardella,D., Zingale,G.A., Caraci,F. and Grasso,G. \<br\>Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme\<br\>ACS Chem Neurosci (2022) 13, 1588-1593. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Distefano,A., Antonio Zingale,G. and Grasso,G. \<br\>An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme\<br\>Anal Bioanal Chem (2022) 414, 4793-4802. PubMed  Europe PubMed DOI
  11. Lesire,L., Leroux,F., Deprez-Poulain,R. and Deprez,B. \<br\>Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?\<br\>Cells (2022) 11, PubMed  Europe PubMed DOI  PMC  EPMC  V
  12. Martin-Martin,Y., Perez-Garcia,A., Torrecilla-Parra,M., Fernandez-de Frutos,M., Pardo-Marques,V., Casarejos,M.J., Busto,R. and Ramirez,C.M. \<br\>New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs\<br\>Cells (2022) 11, PubMed  Europe PubMed DOI  PMC  EPMC
  13. Pablos,M., Casanueva-Alvarez,E., Gonzalez-Casimiro,C.M., Merino,B., Perdomo,G. and Cozar-Castellano,I. \<br\>Primary Cilia in Pancreatic beta- and alpha-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme\<br\>Front Endocrinol (Lausanne) (2022) 13, 922825. PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Tundo,G.R., Sbardella,D., Oddone,F., Grasso,G., Marini,S., Atzori,M.G., Santoro,A.M., Milardi,D., Bellia,F., Macari,G., Graziani,G., Polticelli,F., Cascio,P., Parravano,M. and Coletta,M. \<br\>Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug\<br\>Biomolecules (2022) 12, PubMed  Europe PubMed DOI  PMC  EPMC  K  I
    15. 2021
  15. Adamek,R.N., Suire,C.N., Stokes,R.W., Brizuela,M.K., Cohen,S.M. and Leissring,M.A. \<br\>Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme\<br\>ChemMedChem (2021) PubMed  Europe PubMed DOI  I
  16. Inoue,Y., Masuda,T., Misumi,Y., Ando,Y. and Ueda,M. \<br\>Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus\<br\>Neurosci Lett (2021) 762, 136136. PubMed  Europe PubMed DOI
  17. Leissring,M.A., Gonzalez-Casimiro,C.M., Merino,B., Suire,C.N. and Perdomo,G. \<br\>Targeting Insulin-Degrading Enzyme in Insulin Clearance\<br\>Int J Mol Sci (2021) 22, PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Leissring,M.A. \<br\>Insulin-Degrading Enzyme: Paradoxes and Possibilities\<br\>Cells (2021) 10, PubMed  Europe PubMed DOI  PMC  EPMC
  19. Li,C., Wang,Y., Zhu,G., Shang,Y., Jiefang,K. and Li,J. \<br\>IL-6 induced enhanced clearance of proANP and ANP by insulin-degrading enzyme in T1DM mouse\<br\>Biochem Cell Biol (2021) PubMed  Europe PubMed DOI
  20. Nash,Y., Ganoth,A., Borenstein-Auerbach,N., Levy-Barazany,H., Goldsmith,G., Kopelevich,A., Pozyuchenko,K., Sakhneny,L., Lazdon,E., Blanga-Kanfi,S., Alhadeff,R., Benromano,T., Landsman,L., Tsfadia,Y. and Frenkel,D. \<br\>From virus to diabetes therapy: Characterization of a specific insulin-degrading enzyme inhibitor for diabetes treatment\<br\>FASEB J (2021) 35, e21374. PubMed  Europe PubMed DOI
  21. Ramaraju,B., Nelson,S.L., Zheng,W., Ghirlando,R. and Deshmukh,L. \<br\>Quantitative NMR Study of Insulin-Degrading Enzyme Using Amyloid-beta and HIV-1 p6 Elucidates Its Chaperone Activity\<br\>Biochemistry (2021) PubMed  Europe PubMed DOI
  22. Sousa,L., Guarda,M., Meneses,M.J., Macedo,M.P. and Vicente Miranda,H. \<br\>Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases\<br\>J Pathol (2021) PubMed  Europe PubMed DOI  V
  23. Waclawczyk,D., Silberring,J. and Grasso,G. \<br\>The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism\<br\>J Enzyme Inhib Med Chem (2021) 36, 183-187. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Zheng,Q., Kebede,M.T., Lee,B., Krasinski,C.A., Islam,S., Wurfl,L.A., Kemeh,M.M., Ivancic,V.A., Jakobsche,C.E., Spratt,D.E. and Lazo,N.D. \<br\>Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme\<br\>Antioxidants (Basel) (2021) 10, PubMed  Europe PubMed DOI  PMC  EPMC  I
    25. 2020
  25. Bernstein,H.G., Keilhoff,G., Dobrowolny,H. and Steiner,J. \<br\>Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme's implication for Alzheimer s disease pathology?\<br\>Eur Arch Psychiatry Clin Neurosci (2020) 270, 495-496. PubMed  Europe PubMed DOI
  26. Fu,H., Liu,B., Li,L. and Lemere,C.A. \<br\>Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme\<br\>Neuroscience (2020) 443, 30-43. PubMed  Europe PubMed DOI
  27. Kim,N. and Lee,H.J. \<br\>Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease\<br\>Biomed Res Int (2020) 2020, 2010728. PubMed  Europe PubMed DOI  PMC  EPMC  V
  28. Lauer,A.A., Mett,J., Janitschke,D., Thiel,A., Stahlmann,C.P., Bachmann,C.M., Ritzmann,F., Schrul,B., Muller,U.C., Stein,R., Riemenschneider,M., Grimm,H.S., Hartmann,T. and Grimm,M.O.W. \<br\>Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease\<br\>Aging Cell (2020) e13264. PubMed  Europe PubMed DOI
  29. Merino,B., Fernandez-Diaz,C.M., Parrado-Fernandez,C., Gonzalez-Casimiro,C.M., Postigo-Casado,T., Lobaton,C.D., Leissring,M.A., Cozar-Castellano,I. and Perdomo,G. \<br\>Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice\<br\>Metabolism (2020) 113, 154352. PubMed  Europe PubMed DOI
  30. Minchenko,D.O., Khita,O.O., Tsymbal,D.O., Danilovskyi,S.V., Rudnytska,O.V., Halkin,O.V., Kryvdiuk,I.V., Smeshkova,M.V., Yakymchuk,M.M., Bezrodnyi,B.H. and Minchenko,O.H. \<br\>Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation\<br\>Endocr Regul (2020) 54, 183-195. PubMed  Europe PubMed DOI
  31. Suire,C.N., Brizuela,M.K. and Leissring,M.A. \<br\>Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin\<br\>Methods Protoc (2020) 3, PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2019
  32. Bellia,F., Lanza,V., Ahmed,I.M.M., Garcia-Vinuales,S., Veiss,E., Arizzi,M., Calcagno,D., Milardi,D. and Grasso,G. \<br\>Site directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus E1-like activity: the role of metal ions\<br\>Metallomics (2019) 11, 278-281. PubMed  Europe PubMed DOI
  33. Borges,D.O., Meneses,M.J., Dias,T.R., Martins,F.O., Oliveira,P.F., Alves,M.G. and Macedo,M.P. \<br\>Data on metabolic profile of insulin-degrading enzyme knockout mice\<br\>Data Brief (2019) 25, 104023. PubMed  Europe PubMed DOI  PMC  EPMC  K
  34. Fernandez-Diaz,C.M., Merino,B., Lopez-Acosta,J.F., Cidad,P., de la Fuente,M.A., Lobaton,C.D., Moreno,A., Leissring,M.A., Perdomo,G. and Cozar-Castellano,I. \<br\>Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity\<br\>Am J Physiol Endocrinol Metab (2019) 317, E805. PubMed  Europe PubMed DOI  K
  35. Leng,Q.Y., Zheng,J.H., Xu,H.D., Adu-Asiamah,P., Zhang,Y., Du,B.W. and Zhang,L. \<br\>[Cloning and expression analysis of chicken circular transcript of insulin degrading enzyme gene]\<br\>Yi Chuan (2019) 41, 1129-1137. PubMed  Europe PubMed DOI
  36. Leroux,F., Bosc,D., Beghyn,T., Hermant,P., Warenghem,S., Landry,V., Pottiez,V., Guillaume,V., Charton,J., Herledan,A., Urata,S., Liang,W., Sheng,L., Tang,W.J., Deprez,B. and Deprez-Poulain,R. \<br\>Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening\<br\>Eur J Med Chem (2019) 179, 557-566. PubMed  Europe PubMed DOI  I
  37. Maianti,J.P., Tan,G.A., Vetere,A., Welsh,A.J., Wagner,B.K., Seeliger,M.A. and Liu,D.R. \<br\>Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme\<br\>Nat Chem Biol (2019) 15, 565-574. PubMed  Europe PubMed DOI  S  I
  38. Meneses,M.J., Borges,D.O., Dias,T.R., Martins,F.O., Oliveira,P.F., Macedo,M.P. and Alves,M.G. \<br\>Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality\<br\>Mol Cell Endocrinol (2019) 486, 11-17. PubMed  Europe PubMed DOI  K
  39. Zhang,S., Chen,L., Li,F., Li,N., Feng,Y. and Xiao,L. \<br\>Divergent copies of a Cryptosporidium parvum-specific subtelomeric gene\<br\>Microorganisms (2019) 7, PubMed  Europe PubMed DOI
    40. 2018
  40. Grasso,G. \<br\>Commentary on Ivancic et al.: Enzyme Kinetics from Circular Dichroism of Insulin Reveals Mechanistic Insights into the Regulation of Insulin-degrading Enzyme\<br\>Biosci Rep (2018) PubMed  Europe PubMed DOI
  41. Hayrabedyan,S., Todorova,K., Spinelli,M., Barnea,E.R. and Mueller,M. \<br\>The core sequence of PIF competes for insulin/amyloid beta in insulin degrading enzyme: potential treatment for Alzheimer's disease\<br\>Oncotarget (2018) 9, 33884-33895. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Ivancic,V.A., Krasinski,C.A., Zheng,Q., Meservier,R.J., Spratt,D.E. and Lazo,N.D. \<br\>Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme\<br\>Biosci Rep (2018) PubMed  Europe PubMed DOI
  43. Krasinski,C.A., Ivancic,V.A., Zheng,Q., Spratt,D.E. and Lazo,N.D. \<br\>Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Abeta42\<br\>ACS Omega (2018) 3, 13275-13282. PubMed  Europe PubMed DOI  PMC  EPMC  I
  44. Krasinski,C.A., Zheng,Q., Ivancic,V.A., Spratt,D.E. and Lazo,N.D. \<br\>The longest amyloid-beta precursor protein intracellular domain produced with Abeta42 forms beta-sheet-containing monomers that self-assemble and are proteolyzed by insulin-degrading enzyme\<br\>ACS Chem Neurosci (2018) 9, 2892-2897. PubMed  Europe PubMed DOI
  45. Kurochkin,I.V., Guarnera,E. and Berezovsky,I.N. \<br\>Insulin-degrading enzyme in the fight against Alzheimer's disease\<br\>Trends Pharmacol Sci (2018) 39, 49-58. PubMed  Europe PubMed DOI
  46. Lai,R., Tang,W.J. and Li,H. \<br\>Catalytic mechanism of amyloid-beta peptide degradation by insulin degrading enzyme: insights from quantum mechanics and molecular mechanics style Moller-Plesset second order perturbation theory calculation\<br\>J Chem Inf Model (2018) 58, 1926-1934. PubMed  Europe PubMed DOI
  47. Stefanidis,L., Fusco,N.D., Cooper,S.E., Smith-Carpenter,J.E. and Alper,B.J. \<br\>Molecular determinants of substrate specificity in human insulin-degrading enzyme\<br\>Biochemistry (2018) 57, 4903-4914. PubMed  Europe PubMed DOI
  48. Suire,C.N., Nainar,S., Fazio,M., Kreutzer,A.G., Paymozd-Yazdi,T., Topper,C.L., Thompson,C.R. and Leissring,M.A. \<br\>Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display\<br\>PLoS ONE (2018) 13, e0193101. PubMed  Europe PubMed DOI  I
  49. Villa-Perez,P., Merino,B., Fernandez-Diaz,C.M., Cidad,P., Lobaton,C.D., Moreno,A., Muturi,H.T., Ghadieh,H.E., Najjar,S.M., Leissring,M.A., Cozar-Castellano,I. and Perdomo,G. \<br\>Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice\<br\>Metabolism (2018) 88, 1-11. PubMed  Europe PubMed DOI  K
  50. Yang,D., Qin,W., Shi,X., Zhu,B., Xie,M., Zhao,H., Teng,B., Wu,Y., Zhao,R., Yin,F., Ren,P., Liu,L. and Li,Z. \<br\>Stabilized beta-hairpin peptide inhibits insulin degrading enzyme\<br\>J Med Chem (2018) 61, 8174-8185. PubMed  Europe PubMed DOI  I
  51. Zhang,Y. and Wang,P. \<br\>Age-related increase of insulin-degrading enzyme is inversely correlated with cognitive function in APPswe/PS1dE9 mice\<br\>Med Sci Monit (2018) 24, 2446-2455. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Zhang,Z., Liang,W.G., Bailey,L.J., Tan,Y.Z., Wei,H., Wang,A., Farcasanu,M., Woods,V.A., McCord,L.A., Lee,D., Shang,W., Deprez-Poulain,R., Deprez,B., Liu,D.R., Koide,A., Koide,S., Kossiakoff,A.A., Li,S., Carragher,B., Potter,C.S. and Tang,W.J. \<br\>Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme\<br\>elife (2018) 7, PubMed  Europe PubMed DOI  S
    53. 2017
  53. Hahn,F., Schmalen,A., Setz,C., Friedrich,M., Schlosser,S., Kolle,J., Spranger,R., Rauch,P., Fraedrich,K., Reif,T., Karius-Fischer,J., Balasubramanyam,A., Henklein,P., Fossen,T. and Schubert,U. \<br\>Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner\<br\>PLoS ONE (2017) 12, e0174254. PubMed  Europe PubMed DOI
  54. Jamal,S., Goyal,S., Shanker,A. and Grover,A. \<br\>Machine learning and molecular dynamics based insights into mode of actions of insulin degrading enzyme modulators\<br\>Comb Chem High Throughput Screen (2017) 20, 279-291. PubMed  Europe PubMed
  55. Kurochkin,I.V., Guarnera,E., Wong,J.H., Eisenhaber,F. and Berezovsky,I.N. \<br\>Toward allosterically increased catalytic activity of insulin-degrading enzyme against amyloid peptides\<br\>Biochemistry (2017) 56, 228-239. PubMed  Europe PubMed DOI
  56. Li,H., Wu,J., Zhu,L., Sha,L., Yang,S., Wei,J., Ji,L., Tang,X., Mao,K., Cao,L., Wei,N., Xie,W. and Yang,Z. \<br\>Insulin degrading enzyme contributes to the pathology in a mixed model of type 2 diabetes and Alzheimer's disease\<br\>Biosci Rep (2017) PubMed  Europe PubMed DOI
  57. Song,E.S., Jang,H., Guo,H.F., Juliano,M.A., Juliano,L., Morris,A.J., Galperin,E., Rodgers,D.W. and Hersh,L.B. \<br\>Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes\<br\>Proc Natl Acad Sci U S A (2017) 114, E2826-E2835. PubMed  Europe PubMed DOI
  58. Tundo,G.R., Sbardella,D., Ciaccio,C., Grasso,G., Gioia,M., Coletta,A., Polticelli,F., Di Pierro,D., Milardi,D., van Endert,P., Marini,S. and Coletta,M. \<br\>Multiple functions of insulin-degrading enzyme: a metabolic crosslight?\<br\>Crit Rev Biochem Mol Biol (2017) 52, 554-582. PubMed  Europe PubMed DOI
    59. 2016
  59. Cai,P., Zhong,W., Jia,M., Yu,C., Peng,Y., Wang,Y., Wang,H., Zeng,C., Bai,Y. and Wang,X. \<br\>The gene polymorphisms of insulin degrading enzyme (IDE) are associated with the risk of coronary heart disease in Chinese Han population\<br\>Int J Clin Exp Pathol (2016) 9, 5544-5551.  M
  60. Grimm,M.O., Mett,J., Stahlmann,C.P., Haupenthal,V.J., Blumel,T., Stotzel,H., Grimm,H.S. and Hartmann,T. \<br\>Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-beta by affecting insulin-degrading enzyme\<br\>Biochem Cell Biol (2016) 94, 534-542. PubMed  Europe PubMed DOI
  61. Hogan,M.F., Meier,D.T., Zraika,S., Templin,A.T., Mellati,M., Hull,R.L., Leissring,M.A. and Kahn,S.E. \<br\>Inhibition of insulin-degrading enzyme does not increase islet amyloid deposition in vitro\<br\>Endocrinology (2016) 157, 3462-3468. PubMed  Europe PubMed DOI  I
  62. Hubin,E., Cioffi,F., Rozenski,J., Van Nuland,N.A. and Broersen,K. \<br\>Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation states\<br\>Biochim Biophys Acta (2016) 1860, 1281-1290. PubMed  Europe PubMed DOI  P
  63. Lukman,S. \<br\>Novel druggable sites of insulin-degrading enzyme identified through applied structural bioinformatics analysis\<br\>Procedia Comput Sci (2016) 80, 2292-2296. DOI  I
  64. Paul,T.J., Barman,A., Ozbil,M., Bora,R.P., Zhang,T., Sharma,G., Hoffmann,Z. and Prabhakar,R. \<br\>Mechanisms of peptide hydrolysis by aspartyl and metalloproteases\<br\>Phys Chem Chem Phys (2016) 18, 24790-24801. PubMed  Europe PubMed DOI
  65. Pivovarova,O., Hohn,A., Grune,T., Pfeiffer,A.F. and Rudovich,N. \<br\>Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?\<br\>Ann Med (2016) 48, 614-624. PubMed  Europe PubMed DOI  T  I
  66. Son,S.M., Cha,M.Y., Choi,H., Kang,S., Choi,H., Lee,M.S., Park,S.A. and Mook-Jung,I. \<br\>Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease\<br\>Autophagy (2016) 12, 784-800. PubMed  Europe PubMed DOI
  67. Tang,W.J. \<br\>Targeting insulin-degrading enzyme to treat type 2 diabetes mellitus\<br\>Trends Endocrinol Metab (2016) 27, 24-34. PubMed  Europe PubMed DOI  I
  68. Tundo,G.R., Di Muzio,E., Ciaccio,C., Sbardella,D., Di Pierro,D., Polticelli,F., Coletta,M. and Marini,S. \<br\>Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin\<br\>FEBS J (2016) 283, 3755-3770. PubMed  Europe PubMed DOI
    69. 2015
  69. Abdul-Hay,S.O., Bannister,T.D., Wang,H., Cameron,M.D., Caulfield,T.R., Masson,A., Bertrand,J., Howard,E.A., McGuire,M.P., Crisafulli,U., Rosenberry,T.R., Topper,C.L., Thompson,C.R., Schurer,S.C., Madoux,F., Hodder,P. and Leissring,M.A. \<br\>Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors\<br\>ACS Chem Biol (2015) 10, 2716-2724. PubMed  Europe PubMed DOI  I
  70. Charton,J., Gauriot,M., Totobenazara,J., Hennuyer,N., Dumont,J., Bosc,D., Marechal,X., Elbakali,J., Herledan,A., Wen,X., Ronco,C., Gras-Masse,H., Heninot,A., Pottiez,V., Landry,V., Staels,B., Liang,W.G., Leroux,F., Tang,W.J., Deprez,B. and Deprez-Poulain,R. \<br\>Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme\<br\>Eur J Med Chem (2015) 90C, 547-567. PubMed  Europe PubMed DOI  S  I
  71. Cheng,H., Wang,L., Shi,T., Shang,Y. and Jiang,L. \<br\>Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis\<br\>Int J Neurosci (2015) 125, 328-335. PubMed  Europe PubMed DOI  M
  72. Del Campo,M., Stargardt,A., Veerhuis,R., Reits,E. and Teunissen,C.E. \<br\>Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Abeta by insulin degrading enzyme (IDE) in Alzheimer's disease\<br\>Neurosci Lett (2015) 589C, 47-51. PubMed  Europe PubMed DOI
  73. Deprez-Poulain,R., Hennuyer,N., Bosc,D., Liang,W.G., Enee,E., Marechal,X., Charton,J., Totobenazara,J., Berte,G., Jahklal,J., Verdelet,T., Dumont,J., Dassonneville,S., Woitrain,E., Gauriot,M., Paquet,C., Duplan,I., Hermant,P., Cantrelle,F.X., Sevin,E., Culot,M., Landry,V., Herledan,A., Piveteau,C., Lippens,G., Leroux,F., Tang,W.J., van Endert,P., Staels,B. and Deprez,B. \<br\>Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice\<br\>Nat Commun (2015) 6, 8250. PubMed  Europe PubMed DOI  PMC  EPMC  I
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