$VAR1 = undef;

Summary for peptidase M14.004: carboxypeptidase N

Names
MEROPS Name	carboxypeptidase N
Other names	anaphylatoxin inactivator, arginine carboxypeptidase, carboxypeptidase K, CPN1 g.p. (Homo sapiens), creatine kinase conversion factor, kininase I, lysine carboxypeptidase, plasma carboxypeptidase B

Domain architecture

MEROPS Classification
Classification	Clan MC >> Subclan (none) >> Family M14 >> Subfamily B >> M14.004
Holotype	carboxypeptidase N (Homo sapiens), Uniprot accession P15169 (peptidase unit: 15-340), MERNUM MER0001198
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00209
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.3
Enzymology	BRENDA database
Proteolytic events	CutDB database (4 cleavages)
Physiology	Destroys vasoactive peptides in the circulation. May affect binding of plasminogen to cells.
Other databases	TREEFAM	http://www.treefam.org/family/TF315592
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/lgk/-KR/-/-/- (based on 15 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'
Gly	0	2	2	2	0
Pro	0	0	1	0	0
Ala	2	2	0	4	0
Val	1	0	0	0	0
Leu	1	0	6	2	0
Ile	0	0	0	1	0
Met	1	0	0	0	0
Phe	1	0	0	1	0
Tyr	0	1	0	1	0
Trp	0	0	0	0	0
Ser	1	2	0	0	0
Thr	1	0	1	0	0
Cys	0	0	0	0	0
Asn	0	0	0	1	0
Gln	1	3	0	1	0
Asp	0	0	0	0	0
Glu	0	1	0	1	0
Lys	3	1	2	1	8
Arg	0	0	0	0	7
His	0	0	0	0	0

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
CPN1	10		ENSG00000120054	1369	CPN1	603103