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Literature for peptidase M14.004: carboxypeptidase N

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Alfaro,E., Diaz-Garcia,E., Garcia-Tovar,S., Zamarron,E., Mangas,A., Galera,R., Nanwani-Nanwani,K., Perez-de-Diego,R., Lopez-Collazo,E., Garcia-Rio,F. and Cubillos-Zapata,C.
    Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity
    Front Immunol13, 909342-909342. PubMed  Europe PubMed DOI
    2. 2021
  2. Zhou,Q., Zhao,L., Shao,Z., Declerck,P., Leung,L.L.K. and Morser,J.
    Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice
    J Thromb Haemost20, 238-244. PubMed  Europe PubMed DOI
    3. 2020
  3. Cui,R., Wang,C., Zhao,Q., Wang,Y. and Li,Y.
    Serum Carboxypeptidase N 1 Serves as a Potential Biomarker Complementing CA15-3 for Breast Cancer
    Anticancer Agents Med Chem PubMed  Europe PubMed DOI
    4. 2018
  4. Morser,J., Shao,Z., Nishimura,T., Zhou,Q., Zhao,L., Higgins,J. and Leung,L.L.K.
    Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice
    J Thromb Haemost16, 991-1002. PubMed  Europe PubMed DOI  K
    5. 2017
  5. Wu,T.Y., Wang,Y.S., Song,Y.C., Chen,Z.Y., Chen,Y.T., Chiu,C.C. and Wu,C.Y.
    Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development
    Sci Rep7, 1852-1852. PubMed  Europe PubMed DOI
    6. 2014
  6. Godahewa,G.I., Wickramaarachchi,W.D., Whang,I., Bathige,S.D., Lim,B.S., Choi,C.Y., De Zoysa,M., Noh,J.K. and Lee,J.
    Two carboxypeptidase counterparts from rock bream (Oplegnathus fasciatus): Molecular characterization, genomic arrangement and immune responses upon pathogenic stresses
    Vet Immunol Immunopathol162, 180-191. PubMed  Europe PubMed DOI
  7. Hu,X., Wetsel,R.A., Ramos,T.N., Mueller-Ortiz,S.L., Schoeb,T.R. and Barnum,S.R.
    Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis
    Immunobiology219, 104-108. PubMed  Europe PubMed DOI  K
    8. 2012
  8. Darley,M.M., Ramos,T.N., Wetsel,R.A. and Barnum,S.R.
    Deletion of carboxypeptidase N delays onset of experimental cerebral malaria
    Parasite Immunol34, 444-447. PubMed  Europe PubMed DOI  K
  9. Skidgel,R., Tan,F. and Erdos,E.G.
    Lysine carboxypeptidase/carboxypeptidase N
    [ISSN:978-0-12-407744-7]3, 1334-1342. DOI
    10. 2009
  10. Du,X.Y., Zabel,B.A., Myles,T., Allen,S.J., Handel,T.M., Lee,P.P., Butcher,E.C. and Leung,L.L.
    Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets
    J Biol Chem284, 751-758. PubMed  Europe PubMed DOI
  11. Mueller-Ortiz,S.L., Wang,D., Morales,J.E., Li,L., Chang,J.Y. and Wetsel,R.A.
    Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock
    J Immunol182, 6533-6539. PubMed  Europe PubMed DOI  K
    12. 2008
  12. Gils,A.
    Which carboxypeptidase determines the antifibrinolytic potential?
    J Thromb Haemost6, 846-847. PubMed  Europe PubMed DOI
  13. Matthiessen,H.P., Willemse,J., Weber,A., Turecek,P.L., Deiteren,K., Hendriks,D., Ehrlich,H.J. and Schwarz,H.P.
    Ethanol dependence of alpha1-antitrypsin C-terminal Lys truncation mediated by basic carboxypeptidases
    Transfusion48, 314-320. PubMed  Europe PubMed DOI
  14. Walker,J.B., Binette,T.M., Mackova,M., Lambkin,G.R., Mitchell,L. and Bajzar,L.
    Proteolytic cleavage of carboxypeptidase N markedly increases its antifibrinolytic activity
    J Thromb Haemost6, 848-855. PubMed  Europe PubMed DOI
  15. Willemse,J.L., Polla,M., Olsson,T. and Hendriks,D.F.
    Comparative substrate specificity study of carboxypeptidase U (TAFIa) and carboxypeptidase N: development of highly selective CPU substrates as useful tools for assay development
    Clin Chim Acta387, 158-160. PubMed  Europe PubMed DOI  A
    16. 2007
  16. Keil,C., Maskos,K., Than,M., Hoopes,J.T., Huber,R., Tan,F., Deddish,P.A., Erdos,E.G., Skidgel,R.A. and Bode,W.
    Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain
    J Mol Biol366, 504-516. PubMed  Europe PubMed DOI  S
  17. Skidgel,R.A. and Erdos,E.G.
    Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator
    Int Immunopharmacol7, 1888-1899. PubMed  Europe PubMed DOI  V
    18. 2005
  18. [YEAR:17-2-2005]Davis,D.A., Singer,K.E., Luz Sierra,M., Narazaki,M., Yang,F., Fales,H.M., Yarchoan,R. and Tosato,G.
    Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation
    Blood105, 4561-4568. PubMed  Europe PubMed DOI
  19. [YEAR:23-12-2005]Quagraine,M.O., Tan,F., Tamei,H., Erdos,E.G. and Skidgel,R.A.
    Plasmin alters the activity and quaternary structure of human plasma carboxypeptidase N
    Biochem J388, 81-91. PubMed  Europe PubMed DOI
    20. 2004
  20. Matthews,K.W., Mueller-Ortiz,S.L. and Wetsel,R.A.
    Carboxypeptidase N: a pleiotropic regulator of inflammation
    Mol Immunol40, 785-793. PubMed  Europe PubMed DOI
  21. Skidgel,R.A. and Erdos,E.G.
    Lysine carboxypeptidase
    [ISSN:0-12-079610-4]2, 837-840.  V
    22. 2003
  22. Cao,H. and Hegele,R.A.
    DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency
    J Hum Genet48, 20-22. PubMed  Europe PubMed DOI  M
    23. 2000
  23. [YEAR:15-7-2000]Sato,T., Miwa,T., Akatsu,H., Matsukawa,N., Obata,K., Okada,N., Campbell,W. and Okada,H.
    Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not
    J Immunol165, 1053-1058. PubMed  Europe PubMed
    24. 1997
  24. Plow,E.F., Allampallam,K. and Redlitz,A.
    The plasma carboxypeptidases and the regulation of the plasminogen system
    Trend Cardiovasc Med7, 71-75. PubMed  Europe PubMed DOI
    25. 1995
  25. Redlitz,A., Tan,A.K., Eaton,D.L. and Plow,E.F.
    Plasma carboxypeptidases as regulators of the plasminogen system
    J Clin Invest96, 2534-2538. PubMed  Europe PubMed DOI
  26. Skidgel,R.A.
    Human carboxypeptidase N: lysine carboxypeptidase
    Methods Enzymol248, 653-663. PubMed  Europe PubMed DOI  V
    27. 1993
  27. Hendriks,D., Vingron,M., Vriend,G., Wang,W., Nalis,D. and Scharpe,S.
    On the specificity of carboxypeptidase N, a comparative study
    Biol Chem Hoppe Seyler374, 843-849. PubMed  Europe PubMed
    28. 1991
  28. Drapeau,G., Chow,A. and Ward,P.E.
    Metabolism of bradykinin analogs by angiotensin I converting enzyme and carboxypeptidase N
    Peptides12, 631-638. PubMed  Europe PubMed DOI
    29. 1990
  29. Tan,F., Weerasinghe,D.K., Skidgel,R.A., Tamei,H., Kaul,R.K., Roninson,I.B., Schilling,J.W. and Erdos,E.G.
    The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats
    J Biol Chem265, 13-19. PubMed  Europe PubMed
    30. 1989
  30. Gebhard,W., Schube,M. and Eulitz,M.
    cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)
    Eur J Biochem178, 603-607. PubMed  Europe PubMed
  31. Skidgel,R.A., Weerasinghe,D.K. and Erdos,E.G.
    Structure of human carboxypeptidase N (kininase I)
    Adv Exp Med Biol247A, 325-329. PubMed  Europe PubMed
  32. Tan,F., Jackman,H., Skidgel,R.A., Zsigmond,E.K. and Erdos,E.G.
    Protamine inhibits plasma carboxypeptidase N, the inactivator of anaphylatoxins and kinins
    Anesthesiology70, 267-275. PubMed  Europe PubMed
    33. 1987
  33. Michelutti,L., Falter,H., Certossi,S., Marcotte,B. and Mazzuchin,A.
    Isolation and purification of creatine kinase conversion factor from human serum and its identification as carboxypeptidase N
    Clin Biochem20, 21-29. PubMed  Europe PubMed
    34. 1986
  34. Mathews,K.P., Curd,J.G. and Hugli,T.E.
    Decreased synthesis of serum carboxypeptidase N (SCPN) in familial SCPN deficiency
    J Clin Immunol6, 87-91. PubMed  Europe PubMed  K
  35. Skidgel,R.A., Kawahara,M.S. and Hugli,T.E.
    Functional significance of the subunits of carboxypeptidase N (kininase I)
    Adv Exp Med Biol198 Pt A, 375-380. PubMed  Europe PubMed
    36. 1983
  36. Huey,R., Bloor,C.M., Kawahara,M.S. and Hugli,T.E.
    Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissue
    Am J Pathol112, 48-60. PubMed  Europe PubMed  I
    37. 1982
  37. Juillerat-Jeanneret,L., Roth,M. and Bargetzi,J.P.
    Some properties of porcine carboxypeptidase N
    Hoppe Seylers Z Physiol Chem363, 51-58. PubMed  Europe PubMed
  38. Levin,Y., Skidgel,R.A. and Erdos,E.G.
    Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i)
    Proc Natl Acad Sci U S A79, 4618-4622. PubMed  Europe PubMed
  39. Ranby,M.
    Studies on the kinetics of plasminogen activation by tissue plasminogen activator
    Biochim Biophys Acta704, 461-469. PubMed  Europe PubMed
    40. 1981
  40. Plummer,T.H., Jr. and Ryan,T.J.
    A potent mercapto bi-product analogue inhibitor for human carboxypeptidase N
    Biochem Biophys Res Commun98, 448-454. PubMed  Europe PubMed DOI  I
  41. Plummer,T.H., Jr. and Erdos,E.G.
    Human plasma carboxypeptidase N
    Methods Enzymol80, 442-449. PubMed  Europe PubMed DOI  V
    42. 1980
  42. Mathews,K.P., Pan,P.M., Gardner,N.J. and Hugli,T.E.
    Familial carboxypeptidase N deficiency
    Ann Intern Med93, 443-445. PubMed  Europe PubMed  K
    43. 1979
  43. [YEAR:15-10-1979]McKay,T.J., Phelan,A.W. and Plummer,T.H., Jr.
    Comparative studies on human carboxypeptidases B and N
    Arch Biochem Biophys197, 487-492. PubMed  Europe PubMed
  44. [YEAR:17-4-1979]Ondetti,M.A., Condon,M.E., Reid,J., Sabo,E.F., Cheung,H.S. and Cushman,D.W.
    Design of potent and specific inhibitors of carboxypeptidases A and B
    Biochemistry18, 1427-1430. PubMed  Europe PubMed  I
    45. 1978
  45. [YEAR:11-5-1978]Koheil,A. and Forstner,G.
    Isoelectric focusing of carboxypeptidase N
    Biochim Biophys Acta524, 156-161. PubMed  Europe PubMed
  46. [YEAR:10-6-1978]Plummer,T.H., Jr. and Hurwitz,M.Y.
    Human plasma carboxypeptidase N. Isolation and characterization
    J Biol Chem253, 3907-3912. PubMed  Europe PubMed
    47. 1975
  47. Oshima,G., Kato,J. and Erdos,E.G.
    Plasma carboxypeptidase N, subunits and characteristics
    Arch Biochem Biophys170, 132-138. PubMed  Europe PubMed
    48. 1974
  48. Oshima,G., Kato,J. and Erdos,E.G.
    Subunits of human plasma carboxypeptidase N (kininase I; anaphylatoxin inactivator)
    Biochim Biophys Acta365, 344-348.
    49. 1970
  49. Bokisch,V.A. and Muller-Eberhard,H.J.
    Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase
    J Clin Invest49, 2427-2436. PubMed  Europe PubMed DOI
    50. 1967
  50. [YEAR:7-7-1967]Erdos,E.G., Yang,H.Y., Tague,L.L. and Manning,N.
    Carboxypeptidase in blood and other fluids. 3. The esterase activity of the enzyme
    Biochem Pharmacol16, 1287-1297. PubMed  Europe PubMed
    51. 1965
  51. Erdos,E.G., Wohler,I.M., Levine,I.M. and Westerman,M.P.
    Carboxypeptidase in blood and other fluids. Values in human blood in normal and pathological conditions
    Clin Chim Acta11, 39-43. PubMed  Europe PubMed
    52. 1962
  52. Erdos,E.G. and Sloane,E.M.
    An enzyme in human blood plasma that inactivates bradykinin and kallidins
    Biochem Pharmacol11, 585-592. PubMed  Europe PubMed

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