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Literature for peptidase M14.004: carboxypeptidase N

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Alfaro,E., Diaz-Garcia,E., Garcia-Tovar,S., Zamarron,E., Mangas,A., Galera,R., Nanwani-Nanwani,K., Perez-de-Diego,R., Lopez-Collazo,E., Garcia-Rio,F. and Cubillos-Zapata,C.
    Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity
    Front Immunol (2022) 13, 909342-909342. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2021
  2. Zhou,Q., Zhao,L., Shao,Z., Declerck,P., Leung,L.L.K. and Morser,J.
    Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice
    J Thromb Haemost (2021) 20, 238-244. PubMed  Europe PubMed DOI
    3. 2020
  3. Cui,R., Wang,C., Zhao,Q., Wang,Y. and Li,Y.
    Serum Carboxypeptidase N 1 Serves as a Potential Biomarker Complementing CA15-3 for Breast Cancer
    Anticancer Agents Med Chem (2020) PubMed  Europe PubMed DOI
    4. 2018
  4. Morser,J., Shao,Z., Nishimura,T., Zhou,Q., Zhao,L., Higgins,J. and Leung,L.L.K.
    Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice
    J Thromb Haemost (2018) 16, 991-1002. PubMed  Europe PubMed DOI  K
    5. 2017
  5. Wu,T.Y., Wang,Y.S., Song,Y.C., Chen,Z.Y., Chen,Y.T., Chiu,C.C. and Wu,C.Y.
    Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development
    Sci Rep (2017) 7, 1852-1852. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2014
  6. Godahewa,G.I., Wickramaarachchi,W.D., Whang,I., Bathige,S.D., Lim,B.S., Choi,C.Y., De Zoysa,M., Noh,J.K. and Lee,J.
    Two carboxypeptidase counterparts from rock bream (Oplegnathus fasciatus): Molecular characterization, genomic arrangement and immune responses upon pathogenic stresses
    Vet Immunol Immunopathol (2014) 162, 180-191. PubMed  Europe PubMed DOI
  7. Hu,X., Wetsel,R.A., Ramos,T.N., Mueller-Ortiz,S.L., Schoeb,T.R. and Barnum,S.R.
    Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis
    Immunobiology (2014) 219, 104-108. PubMed  Europe PubMed DOI  K
    8. 2012
  8. Darley,M.M., Ramos,T.N., Wetsel,R.A. and Barnum,S.R.
    Deletion of carboxypeptidase N delays onset of experimental cerebral malaria
    Parasite Immunol (2012) 34, 444-447. PubMed  Europe PubMed DOI  K
  9. Skidgel,R., Tan,F. and Erdos,E.G.
    Lysine carboxypeptidase/carboxypeptidase N
    [ISSN:978-0-12-407744-7] (2012) 3, 1334-1342. DOI
    10. 2009
  10. Du,X.Y., Zabel,B.A., Myles,T., Allen,S.J., Handel,T.M., Lee,P.P., Butcher,E.C. and Leung,L.L.
    Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets
    J Biol Chem (2009) 284, 751-758. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Mueller-Ortiz,S.L., Wang,D., Morales,J.E., Li,L., Chang,J.Y. and Wetsel,R.A.
    Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock
    J Immunol (2009) 182, 6533-6539. PubMed  Europe PubMed DOI  K
    12. 2008
  12. Gils,A.
    Which carboxypeptidase determines the antifibrinolytic potential?
    J Thromb Haemost (2008) 6, 846-847. PubMed  Europe PubMed DOI
  13. Matthiessen,H.P., Willemse,J., Weber,A., Turecek,P.L., Deiteren,K., Hendriks,D., Ehrlich,H.J. and Schwarz,H.P.
    Ethanol dependence of alpha1-antitrypsin C-terminal Lys truncation mediated by basic carboxypeptidases
    Transfusion (2008) 48, 314-320. PubMed  Europe PubMed DOI
  14. Walker,J.B., Binette,T.M., Mackova,M., Lambkin,G.R., Mitchell,L. and Bajzar,L.
    Proteolytic cleavage of carboxypeptidase N markedly increases its antifibrinolytic activity
    J Thromb Haemost (2008) 6, 848-855. PubMed  Europe PubMed DOI
  15. Willemse,J.L., Polla,M., Olsson,T. and Hendriks,D.F.
    Comparative substrate specificity study of carboxypeptidase U (TAFIa) and carboxypeptidase N: development of highly selective CPU substrates as useful tools for assay development
    Clin Chim Acta (2008) 387, 158-160. PubMed  Europe PubMed DOI  A
    16. 2007
  16. Keil,C., Maskos,K., Than,M., Hoopes,J.T., Huber,R., Tan,F., Deddish,P.A., Erdos,E.G., Skidgel,R.A. and Bode,W.
    Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain
    J Mol Biol (2007) 366, 504-516. PubMed  Europe PubMed DOI  S
  17. Skidgel,R.A. and Erdos,E.G.
    Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator
    Int Immunopharmacol (2007) 7, 1888-1899. PubMed  Europe PubMed DOI  PMC  EPMC  V
    18. 2005
  18. [YEAR:17-2-2005]Davis,D.A., Singer,K.E., Luz Sierra,M., Narazaki,M., Yang,F., Fales,H.M., Yarchoan,R. and Tosato,G.
    Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation
    Blood (17-2-2005) 105, 4561-4568. PubMed  Europe PubMed DOI  PMC  EPMC
  19. [YEAR:23-12-2005]Quagraine,M.O., Tan,F., Tamei,H., Erdos,E.G. and Skidgel,R.A.
    Plasmin alters the activity and quaternary structure of human plasma carboxypeptidase N
    Biochem J (23-12-2005) 388, 81-91. PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2004
  20. Matthews,K.W., Mueller-Ortiz,S.L. and Wetsel,R.A.
    Carboxypeptidase N: a pleiotropic regulator of inflammation
    Mol Immunol (2004) 40, 785-793. PubMed  Europe PubMed DOI
  21. Skidgel,R.A. and Erdos,E.G.
    Lysine carboxypeptidase
    [ISSN:0-12-079610-4] (2004) 2, 837-840.  V
    22. 2003
  22. Cao,H. and Hegele,R.A.
    DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency
    J Hum Genet (2003) 48, 20-22. PubMed  Europe PubMed DOI  M
    23. 2000
  23. [YEAR:15-7-2000]Sato,T., Miwa,T., Akatsu,H., Matsukawa,N., Obata,K., Okada,N., Campbell,W. and Okada,H.
    Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not
    J Immunol (15-7-2000) 165, 1053-1058. PubMed  Europe PubMed
    24. 1997
  24. Plow,E.F., Allampallam,K. and Redlitz,A.
    The plasma carboxypeptidases and the regulation of the plasminogen system
    Trend.Cardiovasc.Med. (1997) 7, 71-75. PubMed  Europe PubMed DOI
    25. 1995
  25. Redlitz,A., Tan,A.K., Eaton,D.L. and Plow,E.F.
    Plasma carboxypeptidases as regulators of the plasminogen system
    J Clin Invest (1995) 96, 2534-2538. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Skidgel,R.A.
    Human carboxypeptidase N: lysine carboxypeptidase
    Methods Enzymol (1995) 248, 653-663. PubMed  Europe PubMed DOI  V
    27. 1993
  27. Hendriks,D., Vingron,M., Vriend,G., Wang,W., Nalis,D. and Scharpe,S.
    On the specificity of carboxypeptidase N, a comparative study
    Biol Chem Hoppe Seyler (1993) 374, 843-849. PubMed  Europe PubMed
    28. 1991
  28. Drapeau,G., Chow,A. and Ward,P.E.
    Metabolism of bradykinin analogs by angiotensin I converting enzyme and carboxypeptidase N
    Peptides (1991) 12, 631-638. PubMed  Europe PubMed DOI
    29. 1990
  29. Tan,F., Weerasinghe,D.K., Skidgel,R.A., Tamei,H., Kaul,R.K., Roninson,I.B., Schilling,J.W. and Erdos,E.G.
    The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats
    J Biol Chem (1990) 265, 13-19. PubMed  Europe PubMed
    30. 1989
  30. Gebhard,W., Schube,M. and Eulitz,M.
    cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)
    Eur J Biochem (1989) 178, 603-607. PubMed  Europe PubMed
  31. Skidgel,R.A., Weerasinghe,D.K. and Erdos,E.G.
    Structure of human carboxypeptidase N (kininase I)
    Adv Exp Med Biol (1989) 247A, 325-329. PubMed  Europe PubMed
  32. Tan,F., Jackman,H., Skidgel,R.A., Zsigmond,E.K. and Erdos,E.G.
    Protamine inhibits plasma carboxypeptidase N, the inactivator of anaphylatoxins and kinins
    Anesthesiology (1989) 70, 267-275. PubMed  Europe PubMed
    33. 1987
  33. Michelutti,L., Falter,H., Certossi,S., Marcotte,B. and Mazzuchin,A.
    Isolation and purification of creatine kinase conversion factor from human serum and its identification as carboxypeptidase N
    Clin Biochem (1987) 20, 21-29. PubMed  Europe PubMed
    34. 1986
  34. Mathews,K.P., Curd,J.G. and Hugli,T.E.
    Decreased synthesis of serum carboxypeptidase N (SCPN) in familial SCPN deficiency
    J Clin Immunol (1986) 6, 87-91. PubMed  Europe PubMed  K
  35. Skidgel,R.A., Kawahara,M.S. and Hugli,T.E.
    Functional significance of the subunits of carboxypeptidase N (kininase I)
    Adv Exp Med Biol (1986) 198 Pt A, 375-380. PubMed  Europe PubMed
    36. 1983
  36. Huey,R., Bloor,C.M., Kawahara,M.S. and Hugli,T.E.
    Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissue
    Am J Pathol (1983) 112, 48-60. PubMed  Europe PubMed  PMC  EPMC  I
    37. 1982
  37. Juillerat-Jeanneret,L., Roth,M. and Bargetzi,J.P.
    Some properties of porcine carboxypeptidase N
    Hoppe Seylers Z Physiol Chem (1982) 363, 51-58. PubMed  Europe PubMed
  38. Levin,Y., Skidgel,R.A. and Erdos,E.G.
    Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i)
    Proc Natl Acad Sci U S A (1982) 79, 4618-4622. PubMed  Europe PubMed  PMC  EPMC
  39. Ranby,M.
    Studies on the kinetics of plasminogen activation by tissue plasminogen activator
    Biochim Biophys Acta (1982) 704, 461-469. PubMed  Europe PubMed
    40. 1981
  40. Plummer,T.H., Jr. and Erdos,E.G.
    Human plasma carboxypeptidase N
    Methods Enzymol (1981) 80, 442-449. PubMed  Europe PubMed DOI  V
  41. Plummer,T.H., Jr. and Ryan,T.J.
    A potent mercapto bi-product analogue inhibitor for human carboxypeptidase N
    Biochem Biophys Res Commun (1981) 98, 448-454. PubMed  Europe PubMed DOI  I
    42. 1980
  42. Mathews,K.P., Pan,P.M., Gardner,N.J. and Hugli,T.E.
    Familial carboxypeptidase N deficiency
    Ann Intern Med (1980) 93, 443-445. PubMed  Europe PubMed  K
    43. 1979
  43. [YEAR:15-10-1979]McKay,T.J., Phelan,A.W. and Plummer,T.H., Jr.
    Comparative studies on human carboxypeptidases B and N
    Arch Biochem Biophys (15-10-1979) 197, 487-492. PubMed  Europe PubMed
  44. [YEAR:17-4-1979]Ondetti,M.A., Condon,M.E., Reid,J., Sabo,E.F., Cheung,H.S. and Cushman,D.W.
    Design of potent and specific inhibitors of carboxypeptidases A and B
    Biochemistry (17-4-1979) 18, 1427-1430. PubMed  Europe PubMed  I
    45. 1978
  45. [YEAR:11-5-1978]Koheil,A. and Forstner,G.
    Isoelectric focusing of carboxypeptidase N
    Biochim Biophys Acta (11-5-1978) 524, 156-161. PubMed  Europe PubMed
  46. [YEAR:10-6-1978]Plummer,T.H., Jr. and Hurwitz,M.Y.
    Human plasma carboxypeptidase N. Isolation and characterization
    J Biol Chem (10-6-1978) 253, 3907-3912. PubMed  Europe PubMed
    47. 1975
  47. Oshima,G., Kato,J. and Erdos,E.G.
    Plasma carboxypeptidase N, subunits and characteristics
    Arch Biochem Biophys (1975) 170, 132-138. PubMed  Europe PubMed
    48. 1974
  48. Oshima,G., Kato,J. and Erdos,E.G.
    Subunits of human plasma carboxypeptidase N (kininase I; anaphylatoxin inactivator)
    Biochim Biophys Acta (1974) 365, 344-348.
    49. 1970
  49. Bokisch,V.A. and Muller-Eberhard,H.J.
    Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase
    J Clin Invest (1970) 49, 2427-2436. PubMed  Europe PubMed DOI  PMC  EPMC
    50. 1967
  50. [YEAR:7-7-1967]Erdos,E.G., Yang,H.Y., Tague,L.L. and Manning,N.
    Carboxypeptidase in blood and other fluids. 3. The esterase activity of the enzyme
    Biochem Pharmacol (7-7-1967) 16, 1287-1297. PubMed  Europe PubMed
    51. 1965
  51. Erdos,E.G., Wohler,I.M., Levine,I.M. and Westerman,M.P.
    Carboxypeptidase in blood and other fluids. Values in human blood in normal and pathological conditions
    Clin Chim Acta (1965) 11, 39-43. PubMed  Europe PubMed
    52. 1962
  52. Erdos,E.G. and Sloane,E.M.
    An enzyme in human blood plasma that inactivates bradykinin and kallidins
    Biochem Pharmacol (1962) 11, 585-592. PubMed  Europe PubMed

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