Literature for peptidase M14.004: carboxypeptidase N

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2022

Alfaro,E., Diaz-Garcia,E., Garcia-Tovar,S., Zamarron,E., Mangas,A., Galera,R., Nanwani-Nanwani,K., Perez-de-Diego,R., Lopez-Collazo,E., Garcia-Rio,F. and Cubillos-Zapata,C. Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity Front Immunol (2022) 13, 909342-909342. PubMed Europe PubMed DOI PMC EPMC

2021

Zhou,Q., Zhao,L., Shao,Z., Declerck,P., Leung,L.L.K. and Morser,J. Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice J Thromb Haemost (2021) 20, 238-244. PubMed Europe PubMed DOI

2020

Cui,R., Wang,C., Zhao,Q., Wang,Y. and Li,Y. Serum Carboxypeptidase N 1 Serves as a Potential Biomarker Complementing CA15-3 for Breast Cancer Anticancer Agents Med Chem (2020) PubMed Europe PubMed DOI

2018

Morser,J., Shao,Z., Nishimura,T., Zhou,Q., Zhao,L., Higgins,J. and Leung,L.L.K. Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice J Thromb Haemost (2018) 16, 991-1002. PubMed Europe PubMed DOI K

2017

Wu,T.Y., Wang,Y.S., Song,Y.C., Chen,Z.Y., Chen,Y.T., Chiu,C.C. and Wu,C.Y. Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development Sci Rep (2017) 7, 1852-1852. PubMed Europe PubMed DOI PMC EPMC

2014

Godahewa,G.I., Wickramaarachchi,W.D., Whang,I., Bathige,S.D., Lim,B.S., Choi,C.Y., De Zoysa,M., Noh,J.K. and Lee,J. Two carboxypeptidase counterparts from rock bream (Oplegnathus fasciatus): Molecular characterization, genomic arrangement and immune responses upon pathogenic stresses Vet Immunol Immunopathol (2014) 162, 180-191. PubMed Europe PubMed DOI
Hu,X., Wetsel,R.A., Ramos,T.N., Mueller-Ortiz,S.L., Schoeb,T.R. and Barnum,S.R. Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis Immunobiology (2014) 219, 104-108. PubMed Europe PubMed DOI K

2012

Darley,M.M., Ramos,T.N., Wetsel,R.A. and Barnum,S.R. Deletion of carboxypeptidase N delays onset of experimental cerebral malaria Parasite Immunol (2012) 34, 444-447. PubMed Europe PubMed DOI K
Skidgel,R., Tan,F. and Erdos,E.G. Lysine carboxypeptidase/carboxypeptidase N [ISSN:978-0-12-407744-7] (2012) 3, 1334-1342. DOI

2009

Du,X.Y., Zabel,B.A., Myles,T., Allen,S.J., Handel,T.M., Lee,P.P., Butcher,E.C. and Leung,L.L. Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets J Biol Chem (2009) 284, 751-758. PubMed Europe PubMed DOI PMC EPMC
Mueller-Ortiz,S.L., Wang,D., Morales,J.E., Li,L., Chang,J.Y. and Wetsel,R.A. Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock J Immunol (2009) 182, 6533-6539. PubMed Europe PubMed DOI K

2008

Gils,A. Which carboxypeptidase determines the antifibrinolytic potential? J Thromb Haemost (2008) 6, 846-847. PubMed Europe PubMed DOI
Matthiessen,H.P., Willemse,J., Weber,A., Turecek,P.L., Deiteren,K., Hendriks,D., Ehrlich,H.J. and Schwarz,H.P. Ethanol dependence of alpha1-antitrypsin C-terminal Lys truncation mediated by basic carboxypeptidases Transfusion (2008) 48, 314-320. PubMed Europe PubMed DOI
Walker,J.B., Binette,T.M., Mackova,M., Lambkin,G.R., Mitchell,L. and Bajzar,L. Proteolytic cleavage of carboxypeptidase N markedly increases its antifibrinolytic activity J Thromb Haemost (2008) 6, 848-855. PubMed Europe PubMed DOI
Willemse,J.L., Polla,M., Olsson,T. and Hendriks,D.F. Comparative substrate specificity study of carboxypeptidase U (TAFIa) and carboxypeptidase N: development of highly selective CPU substrates as useful tools for assay development Clin Chim Acta (2008) 387, 158-160. PubMed Europe PubMed DOI A

2007

Keil,C., Maskos,K., Than,M., Hoopes,J.T., Huber,R., Tan,F., Deddish,P.A., Erdos,E.G., Skidgel,R.A. and Bode,W. Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain J Mol Biol (2007) 366, 504-516. PubMed Europe PubMed DOI S
Skidgel,R.A. and Erdos,E.G. Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator Int Immunopharmacol (2007) 7, 1888-1899. PubMed Europe PubMed DOI PMC EPMC V

2005

[YEAR:17-2-2005]Davis,D.A., Singer,K.E., Luz Sierra,M., Narazaki,M., Yang,F., Fales,H.M., Yarchoan,R. and Tosato,G. Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation Blood (17-2-2005) 105, 4561-4568. PubMed Europe PubMed DOI PMC EPMC
[YEAR:23-12-2005]Quagraine,M.O., Tan,F., Tamei,H., Erdos,E.G. and Skidgel,R.A. Plasmin alters the activity and quaternary structure of human plasma carboxypeptidase N Biochem J (23-12-2005) 388, 81-91. PubMed Europe PubMed DOI PMC EPMC

2004

Matthews,K.W., Mueller-Ortiz,S.L. and Wetsel,R.A. Carboxypeptidase N: a pleiotropic regulator of inflammation Mol Immunol (2004) 40, 785-793. PubMed Europe PubMed DOI
Skidgel,R.A. and Erdos,E.G. Lysine carboxypeptidase [ISSN:0-12-079610-4] (2004) 2, 837-840. V

2003

Cao,H. and Hegele,R.A. DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency J Hum Genet (2003) 48, 20-22. PubMed Europe PubMed DOI M

2000

[YEAR:15-7-2000]Sato,T., Miwa,T., Akatsu,H., Matsukawa,N., Obata,K., Okada,N., Campbell,W. and Okada,H. Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not J Immunol (15-7-2000) 165, 1053-1058. PubMed Europe PubMed

1997

Plow,E.F., Allampallam,K. and Redlitz,A. The plasma carboxypeptidases and the regulation of the plasminogen system Trend.Cardiovasc.Med. (1997) 7, 71-75. PubMed Europe PubMed DOI

1995

Redlitz,A., Tan,A.K., Eaton,D.L. and Plow,E.F. Plasma carboxypeptidases as regulators of the plasminogen system J Clin Invest (1995) 96, 2534-2538. PubMed Europe PubMed DOI PMC EPMC
Skidgel,R.A. Human carboxypeptidase N: lysine carboxypeptidase Methods Enzymol (1995) 248, 653-663. PubMed Europe PubMed DOI V

1993

Hendriks,D., Vingron,M., Vriend,G., Wang,W., Nalis,D. and Scharpe,S. On the specificity of carboxypeptidase N, a comparative study Biol Chem Hoppe Seyler (1993) 374, 843-849. PubMed Europe PubMed

1991

Drapeau,G., Chow,A. and Ward,P.E. Metabolism of bradykinin analogs by angiotensin I converting enzyme and carboxypeptidase N Peptides (1991) 12, 631-638. PubMed Europe PubMed DOI

1990

Tan,F., Weerasinghe,D.K., Skidgel,R.A., Tamei,H., Kaul,R.K., Roninson,I.B., Schilling,J.W. and Erdos,E.G. The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats J Biol Chem (1990) 265, 13-19. PubMed Europe PubMed

1989

Gebhard,W., Schube,M. and Eulitz,M. cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1) Eur J Biochem (1989) 178, 603-607. PubMed Europe PubMed
Skidgel,R.A., Weerasinghe,D.K. and Erdos,E.G. Structure of human carboxypeptidase N (kininase I) Adv Exp Med Biol (1989) 247A, 325-329. PubMed Europe PubMed
Tan,F., Jackman,H., Skidgel,R.A., Zsigmond,E.K. and Erdos,E.G. Protamine inhibits plasma carboxypeptidase N, the inactivator of anaphylatoxins and kinins Anesthesiology (1989) 70, 267-275. PubMed Europe PubMed

1987

Michelutti,L., Falter,H., Certossi,S., Marcotte,B. and Mazzuchin,A. Isolation and purification of creatine kinase conversion factor from human serum and its identification as carboxypeptidase N Clin Biochem (1987) 20, 21-29. PubMed Europe PubMed

1986

Mathews,K.P., Curd,J.G. and Hugli,T.E. Decreased synthesis of serum carboxypeptidase N (SCPN) in familial SCPN deficiency J Clin Immunol (1986) 6, 87-91. PubMed Europe PubMed K
Skidgel,R.A., Kawahara,M.S. and Hugli,T.E. Functional significance of the subunits of carboxypeptidase N (kininase I) Adv Exp Med Biol (1986) 198 Pt A, 375-380. PubMed Europe PubMed

1983

Huey,R., Bloor,C.M., Kawahara,M.S. and Hugli,T.E. Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissue Am J Pathol (1983) 112, 48-60. PubMed Europe PubMed PMC EPMC I

1982

Juillerat-Jeanneret,L., Roth,M. and Bargetzi,J.P. Some properties of porcine carboxypeptidase N Hoppe Seylers Z Physiol Chem (1982) 363, 51-58. PubMed Europe PubMed
Levin,Y., Skidgel,R.A. and Erdos,E.G. Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i) Proc Natl Acad Sci U S A (1982) 79, 4618-4622. PubMed Europe PubMed PMC EPMC
Ranby,M. Studies on the kinetics of plasminogen activation by tissue plasminogen activator Biochim Biophys Acta (1982) 704, 461-469. PubMed Europe PubMed

1981

Plummer,T.H., Jr. and Erdos,E.G. Human plasma carboxypeptidase N Methods Enzymol (1981) 80, 442-449. PubMed Europe PubMed DOI V
Plummer,T.H., Jr. and Ryan,T.J. A potent mercapto bi-product analogue inhibitor for human carboxypeptidase N Biochem Biophys Res Commun (1981) 98, 448-454. PubMed Europe PubMed DOI I

1980

Mathews,K.P., Pan,P.M., Gardner,N.J. and Hugli,T.E. Familial carboxypeptidase N deficiency Ann Intern Med (1980) 93, 443-445. PubMed Europe PubMed K

1979

[YEAR:15-10-1979]McKay,T.J., Phelan,A.W. and Plummer,T.H., Jr. Comparative studies on human carboxypeptidases B and N Arch Biochem Biophys (15-10-1979) 197, 487-492. PubMed Europe PubMed
[YEAR:17-4-1979]Ondetti,M.A., Condon,M.E., Reid,J., Sabo,E.F., Cheung,H.S. and Cushman,D.W. Design of potent and specific inhibitors of carboxypeptidases A and B Biochemistry (17-4-1979) 18, 1427-1430. PubMed Europe PubMed I

1978

[YEAR:11-5-1978]Koheil,A. and Forstner,G. Isoelectric focusing of carboxypeptidase N Biochim Biophys Acta (11-5-1978) 524, 156-161. PubMed Europe PubMed
[YEAR:10-6-1978]Plummer,T.H., Jr. and Hurwitz,M.Y. Human plasma carboxypeptidase N. Isolation and characterization J Biol Chem (10-6-1978) 253, 3907-3912. PubMed Europe PubMed

1975

Oshima,G., Kato,J. and Erdos,E.G. Plasma carboxypeptidase N, subunits and characteristics Arch Biochem Biophys (1975) 170, 132-138. PubMed Europe PubMed

1974

Oshima,G., Kato,J. and Erdos,E.G. Subunits of human plasma carboxypeptidase N (kininase I; anaphylatoxin inactivator) Biochim Biophys Acta (1974) 365, 344-348.

1970

Bokisch,V.A. and Muller-Eberhard,H.J. Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase J Clin Invest (1970) 49, 2427-2436. PubMed Europe PubMed DOI PMC EPMC

1967

[YEAR:7-7-1967]Erdos,E.G., Yang,H.Y., Tague,L.L. and Manning,N. Carboxypeptidase in blood and other fluids. 3. The esterase activity of the enzyme Biochem Pharmacol (7-7-1967) 16, 1287-1297. PubMed Europe PubMed

1965

Erdos,E.G., Wohler,I.M., Levine,I.M. and Westerman,M.P. Carboxypeptidase in blood and other fluids. Values in human blood in normal and pathological conditions Clin Chim Acta (1965) 11, 39-43. PubMed Europe PubMed

1962

Erdos,E.G. and Sloane,E.M. An enzyme in human blood plasma that inactivates bradykinin and kallidins Biochem Pharmacol (1962) 11, 585-592. PubMed Europe PubMed