$VAR1 = undef;

Summary for peptidase M13.008: neprilysin-2

Names
MEROPS Name	neprilysin-2
Other names	soluble neutral endopeptidase, soluble secreted endopeptidase, SEP, neprilysin-like peptidase, NEPLP, NL1 protein, MMEL1 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M13 >> Subfamily (none) >> M13.008
Holotype	neprilysin-2 (Homo sapiens), Uniprot accession Q495T6 (peptidase unit: 84-779), MERNUM MER0013406
History	Identifier created: MEROPS 5.1 (22 June 2000)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00204
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Carpentier et al., 2004) mouse: active (Ghaddar et al., 2000)
Other databases	TREEFAM	http://www.treefam.org/family/TF315192
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	hd/-/-/gflv/-/f/fa (based on 16 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	0	3	6	0	0	1	1
Pro	0	1	0	2	0	0	2	1
Ala	0	0	0	0	0	0	0	2
Val	0	0	1	0	3	2	0	0
Leu	0	0	0	2	4	2	1	1
Ile	0	2	1	0	1	0	0	0
Met	0	0	1	0	0	3	0	0
Phe	0	2	1	0	7	3	4	4
Tyr	1	4	1	1	0	0	1	0
Trp	1	0	0	1	1	0	0	0
Ser	0	1	1	1	0	0	0	0
Thr	0	0	0	0	0	0	1	0
Cys	0	1	0	0	0	0	0	0
Asn	0	0	1	0	0	1	0	0
Gln	1	2	3	1	0	0	0	0
Asp	3	0	0	0	0	0	1	0
Glu	0	0	0	0	0	0	0	0
Lys	1	0	2	2	0	0	0	0
Arg	0	1	0	0	0	3	0	0
His	4	2	1	0	0	2	0	0