Literature for peptidase M13.008: neprilysin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: R Splicing, I Inhibitor, K Knockout, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2016
  1. Ul-Haq,Z., Usmani,S., Iqbal,S. and Zia,S.R.
    In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity
    Mol Biosyst12, 1024-1036. PubMed  Europe PubMed DOI  P
  2. 2014
  3. Marr,R.A. and Hafez,D.M.
    Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance
    Front Aging Neurosci6, 187-187. PubMed  Europe PubMed DOI
  4. Takamatsu,K., Ikeda,T., Haruta,M., Matsumura,K., Ogi,Y., Nakagata,N., Uchino,M., Ando,Y., Nishimura,Y. and Senju,S.
    Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing neprilysin-2
    Stem Cell Res13, 442-453. PubMed  Europe PubMed DOI
  5. 2012
  6. Huang,J.Y., Hafez,D.M., James,B.D., Bennett,D.A. and Marr,R.A.
    Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease
    J Alzheimers Dis28, 433-441. PubMed  Europe PubMed DOI
  7. Marr,R.A.
    Neprilysin-2
    [ISSN:978-0-12-407744-7]3, 620-624. DOI
  8. 2011
  9. Hafez,D., Huang,J.Y., Huynh,A.M., Valtierra,S., Rockenstein,E., Bruno,A.M., Lu,B., Desgroseillers,L., Masliah,E. and Marr,R.A.
    Neprilysin-2 is an important beta-amyloid degrading enzyme
    Am J Pathol178, 306-312. PubMed  Europe PubMed DOI  K
  10. 2010
  11. Marr,R.A. and Spencer,B.J.
    NEP-like endopeptidases and Alzheimer's disease [corrected]
    Curr Alzheimer Res7, 223-229. PubMed  Europe PubMed DOI  I
  12. 2009
  13. Bland,N.D., Robinson,P., Thomas,J.E., Shirras,A.D., Turner,A.J. and Isaac,R.E.
    Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2
    Peptides30, 571-574. PubMed  Europe PubMed DOI
  14. 2008
  15. Huang,J.Y., Bruno,A.M., Patel,C.A., Huynh,A.M., Philibert,K.D., Glucksman,M.J. and Marr,R.A.
    Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40
    Neuroscience155, 258-262. PubMed  Europe PubMed DOI  R
  16. Oh-hashi,K., Ohkubo,K., Shizu,K., Fukuda,H., Hirata,Y. and Kiuchi,K.
    Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2
    Mol Cell Biochem313, 103-111. PubMed  Europe PubMed DOI
  17. Whyteside,A.R. and Turner,A.J.
    Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences
    FEBS Lett582, 2382-2386. PubMed  Europe PubMed DOI
  18. 2005
  19. [YEAR:1-8-2005]Voisin,S. and Ouimet,T.
    The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity
    Biochem Biophys Res Commun335, 356-360. PubMed  Europe PubMed DOI
  20. 2004
  21. Carpentier,M., Desgroseillers,L. and Boileau,G.
    Neprilysin-2
    [ISSN:0-12-079610-4]2, 426-429.  V
  22. Carpentier,M., Guillemette,C., Bailey,J.L., Boileau,G., Jeannotte,L., Desgroseillers,L. and Charron,J.
    Reduced fertility in male mice deficient in the zinc metallopeptidase NL1
    Mol Cell Biol24, 4428-4437. PubMed  Europe PubMed DOI  K
  23. Ouimet,T.
    Neprilysin 2: a novel messenger peptide-inactivating metalloprotease
    Protein Pept Lett11, 479-489. PubMed  Europe PubMed DOI
  24. [YEAR:4-8-2004]Voisin,S., Rognan,D., Gros,C. and Ouimet,T.
    A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2
    J Biol Chem279, 46172-46181. PubMed  Europe PubMed DOI
  25. 2003
  26. Carpentier,M., Marcinkiewicz,M., Boileau,G. and Desgroseillers,L.
    The neuropeptide-degrading enzyme NL1 is expressed in specific neurons of mouse brain
    Peptides24, 1083-1091. PubMed  Europe PubMed DOI
  27. Facchinetti,P., Rose,C., Schwartz,J.C. and Ouimet,T.
    Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1
    Neuroscience118, 627-639. PubMed  Europe PubMed DOI
  28. 2002
  29. [YEAR:1-5-2002]Rose,C., Voisin,S., Gros,C., Schwartz,J.C. and Ouimet,T.
    Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin
    Biochem J363, 697-705. PubMed  Europe PubMed DOI
  30. 2001
  31. Bonvouloir,N., Lemieux,N., Crine,P., Boileau,G. and Desgroseillers,L.
    Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family
    DNA Cell Biol20, 493-498. PubMed  Europe PubMed DOI
  32. [YEAR:6-7-2001]Raharjo,S.B., Emoto,N., Ikeda,K., Sato,R., Yokoyama,M. and Matsuo,M.
    Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase
    J Biol Chem276, 25612-25620. PubMed  Europe PubMed DOI  R
  33. 2000
  34. [YEAR:15-4-2000]Ghaddar,G., Ruchon,A.F., Carpentier,M., Marcinkiewicz,M., Seidah,N.G., Crine,P., Desgroseillers,L. and Boileau,G.
    Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family
    Biochem J347, 419-429. PubMed  Europe PubMed DOI
  35. [YEAR:19-5-2000]Ouimet,T., Facchinetti,P., Rose,C., Bonhomme,M.C., Gros,C., Schwartz,J.C. and Tanja,O.
    Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis
    Biochem Biophys Res Commun271, 565-570. PubMed  Europe PubMed DOI
  36. 1999
  37. [YEAR:5-11-1999]Ikeda,K., Emoto,N., Raharjo,S.B., Nurhantari,Y., Saiki,K., Yokoyama,M. and Matsuo,M.
    Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides
    J Biol Chem274, 32469-32477. PubMed  Europe PubMed DOI  I