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Literature for peptidase M13.008: neprilysin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: R Splicing, I Inhibitor, K Knockout, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Selezneva,E.M., Feygina,E.E., Ageeva,L.V., Rozov,F.N., Kopylova,I.V., Altshuler,E.P. and Semenov,A.G.
    Neprilysin 2 catalyses the degradation of natriuretic peptides despite sacubitrilat Inhibition
    Sci Rep (2025) 15, 27401-27401. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2016
  2. Ul-Haq,Z., Usmani,S., Iqbal,S. and Zia,S.R.
    In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity
    Mol Biosyst (2016) 12, 1024-1036. PubMed  Europe PubMed DOI  P
    3. 2014
  3. Marr,R.A. and Hafez,D.M.
    Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance
    Front Aging Neurosci (2014) 6, 187-187. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Takamatsu,K., Ikeda,T., Haruta,M., Matsumura,K., Ogi,Y., Nakagata,N., Uchino,M., Ando,Y., Nishimura,Y. and Senju,S.
    Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing neprilysin-2
    Stem Cell Res (2014) 13, 442-453. PubMed  Europe PubMed DOI
    5. 2012
  5. Huang,J.Y., Hafez,D.M., James,B.D., Bennett,D.A. and Marr,R.A.
    Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease
    J Alzheimers Dis (2012) 28, 433-441. PubMed  Europe PubMed DOI
  6. Marr,R.A.
    Neprilysin-2
    [ISSN:978-0-12-407744-7] (2012) 3, 620-624. DOI
    7. 2011
  7. Hafez,D., Huang,J.Y., Huynh,A.M., Valtierra,S., Rockenstein,E., Bruno,A.M., Lu,B., Desgroseillers,L., Masliah,E. and Marr,R.A.
    Neprilysin-2 is an important beta-amyloid degrading enzyme
    Am J Pathol (2011) 178, 306-312. PubMed  Europe PubMed DOI  K
    8. 2010
  8. Marr,R.A. and Spencer,B.J.
    NEP-like endopeptidases and Alzheimer's disease [corrected]
    Curr Alzheimer Res (2010) 7, 223-229. PubMed  Europe PubMed DOI  I
    9. 2009
  9. Bland,N.D., Robinson,P., Thomas,J.E., Shirras,A.D., Turner,A.J. and Isaac,R.E.
    Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2
    Peptides (2009) 30, 571-574. PubMed  Europe PubMed DOI
    10. 2008
  10. Huang,J.Y., Bruno,A.M., Patel,C.A., Huynh,A.M., Philibert,K.D., Glucksman,M.J. and Marr,R.A.
    Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40
    Neuroscience (2008) 155, 258-262. PubMed  Europe PubMed DOI  PMC  EPMC  R
  11. Oh-hashi,K., Ohkubo,K., Shizu,K., Fukuda,H., Hirata,Y. and Kiuchi,K.
    Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2
    Mol Cell Biochem (2008) 313, 103-111. PubMed  Europe PubMed DOI
  12. Whyteside,A.R. and Turner,A.J.
    Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences
    FEBS Lett (2008) 582, 2382-2386. PubMed  Europe PubMed DOI
    13. 2005
  13. [YEAR:1-8-2005]Voisin,S. and Ouimet,T.
    The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity
    Biochem Biophys Res Commun (1-8-2005) 335, 356-360. PubMed  Europe PubMed DOI
    14. 2004
  14. Carpentier,M., Desgroseillers,L. and Boileau,G.
    Neprilysin-2
    [ISSN:0-12-079610-4] (2004) 2, 426-429.  V
  15. Carpentier,M., Guillemette,C., Bailey,J.L., Boileau,G., Jeannotte,L., Desgroseillers,L. and Charron,J.
    Reduced fertility in male mice deficient in the zinc metallopeptidase NL1
    Mol Cell Biol (2004) 24, 4428-4437. PubMed  Europe PubMed DOI  PMC  EPMC  K
  16. Ouimet,T.
    Neprilysin 2: a novel messenger peptide-inactivating metalloprotease
    Protein Pept Lett (2004) 11, 479-489. PubMed  Europe PubMed DOI
  17. [YEAR:4-8-2004]Voisin,S., Rognan,D., Gros,C. and Ouimet,T.
    A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2
    J Biol Chem (4-8-2004) 279, 46172-46181. PubMed  Europe PubMed DOI
    18. 2003
  18. Carpentier,M., Marcinkiewicz,M., Boileau,G. and Desgroseillers,L.
    The neuropeptide-degrading enzyme NL1 is expressed in specific neurons of mouse brain
    Peptides (2003) 24, 1083-1091. PubMed  Europe PubMed DOI
  19. Facchinetti,P., Rose,C., Schwartz,J.C. and Ouimet,T.
    Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1
    Neuroscience (2003) 118, 627-639. PubMed  Europe PubMed DOI
    20. 2002
  20. [YEAR:1-5-2002]Rose,C., Voisin,S., Gros,C., Schwartz,J.C. and Ouimet,T.
    Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin
    Biochem J (1-5-2002) 363, 697-705. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2001
  21. Bonvouloir,N., Lemieux,N., Crine,P., Boileau,G. and Desgroseillers,L.
    Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family
    DNA Cell Biol (2001) 20, 493-498. PubMed  Europe PubMed DOI
  22. [YEAR:6-7-2001]Raharjo,S.B., Emoto,N., Ikeda,K., Sato,R., Yokoyama,M. and Matsuo,M.
    Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase
    J Biol Chem (6-7-2001) 276, 25612-25620. PubMed  Europe PubMed DOI  R
    23. 2000
  23. [YEAR:15-4-2000]Ghaddar,G., Ruchon,A.F., Carpentier,M., Marcinkiewicz,M., Seidah,N.G., Crine,P., Desgroseillers,L. and Boileau,G.
    Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family
    Biochem J (15-4-2000) 347, 419-429. PubMed  Europe PubMed DOI  PMC  EPMC
  24. [YEAR:19-5-2000]Ouimet,T., Facchinetti,P., Rose,C., Bonhomme,M.C., Gros,C., Schwartz,J.C. and Tanja,O.
    Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis
    Biochem Biophys Res Commun (19-5-2000) 271, 565-570. PubMed  Europe PubMed DOI
    25. 1999
  25. [YEAR:5-11-1999]Ikeda,K., Emoto,N., Raharjo,S.B., Nurhantari,Y., Saiki,K., Yokoyama,M. and Matsuo,M.
    Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides
    J Biol Chem (5-11-1999) 274, 32469-32477. PubMed  Europe PubMed DOI  I

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