$VAR1 = undef;

Summary for peptidase M12.005: procollagen C-peptidase

Names
MEROPS Name	procollagen C-peptidase
Other names	bone morphogenetic protein 1, BMP1 g.p. (Homo sapiens), mammalian tolloid, mTLD, procollagen C-proteinase, XTLD g.p. (Xenopus laevis)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily A >> M12.005
Holotype	procollagen C-peptidase (Homo sapiens), Uniprot accession P13497 (peptidase unit: 127-317), MERNUM MER0001113
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00176
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.19
Enzymology	BRENDA database
Proteolytic events	CutDB database (19 cleavages)
Activity status	human: active (Kessler, 2004) mouse: active (Scott et al., 2000)
Physiology	Cleaves C-terminal propeptide in maturation of type 1 procollagen.
Knockout	Mice homozygous null for procollagen C-proteinase and mammalian tolloid-like 1 protein have been described (Pappano et al., 2003).
Pharmaceutical relevance	Considered to be a drug target for fibrosis (Robinson et al., 2003).
Other databases	TREEFAM	http://www.treefam.org/family/TF314351
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/m/q/gansD/deq/pa/- (based on 42 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	1	1	10	1	3	1	7
Pro	2	3	1	0	0	0	14	3
Ala	1	3	1	9	1	3	9	6
Val	4	1	4	0	0	1	1	0
Leu	3	2	2	1	0	0	1	3
Ile	1	2	1	0	0	0	0	1
Met	0	11	3	0	0	0	1	1
Phe	5	4	0	0	0	0	1	0
Tyr	6	7	2	0	0	0	0	2
Trp	0	1	0	0	0	0	1	0
Ser	5	3	4	6	1	2	2	3
Thr	1	0	1	0	1	2	4	1
Cys	1	0	1	0	0	0	0	0
Asn	1	0	0	6	0	0	2	5
Gln	3	2	13	4	3	6	0	4
Asp	2	0	0	1	35	13	1	0
Glu	2	1	1	2	0	10	4	2
Lys	0	0	0	1	0	0	0	1
Arg	3	1	6	1	0	2	0	2
His	0	0	1	1	0	0	0	1