$VAR1 = undef;

Summary for peptidase M10.005: matrix metallopeptidase-3

Names
MEROPS Name	matrix metallopeptidase-3
Other names	collagenase activating protein, matrix metalloproteinase 3, MMP-3, MMP3, matrix metalloproteinase 6, procollagenase activator, proteoglycanase, stromelysin 1, transin

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.005
Holotype	matrix metallopeptidase-3 (Homo sapiens), Uniprot accession P08254 (peptidase unit: 98-279), MERNUM MER0001068
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00158
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.17
Enzymology	BRENDA database
Proteolytic events	CutDB database (152 cleavages)
Activity status	human: active (Nagase, 2004) mouse: active (Matrisian et al., 1986)
Physiology	Role in turnover of extracellular matrix proteins. Activation of proforms of other matrix metalloendopeptidases.
Knockout	Targeted disruption of the stromelysin-1 gene in mice did not prevent or reduce cartilage destruction in collagen-induced arthritis (Mudgett et al., 1998). The mice show a delay in excisional wound healing due to a failure in wound contraction resulting from impaired contraction of fibroblasts (Bullard et al., 1999a; Bullard et al., 1999b). Lung damage in response to immunoglobulin G immune complexes was alleviated in the deficient mice, indicating that stromelysin-1 is one of the damaging factors in this condition (Warner et al., 2001).
Pharmaceutical relevance	Drug target for prevention of pathological tissue damage.
Pathways	KEGG	Rheumatoid arthritis
	KEGG	TNF signaling pathway
	KEGG	Transcriptional misregulation in cancer
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP3
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/p/ag/-l/-/-/- (based on 2471 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	174	79	431	129	14	54	170	219
Pro	136	731	42	158	18	13	15	186
Ala	224	376	838	398	153	136	306	247
Val	157	294	121	34	257	238	116	161
Leu	192	229	128	98	697	209	171	144
Ile	104	180	32	4	291	138	79	59
Met	54	72	28	44	127	57	30	34
Phe	91	47	73	73	187	78	56	61
Tyr	83	37	49	35	157	59	39	49
Trp	20	8	17	9	29	17	18	11
Ser	160	79	234	223	111	181	177	176
Thr	165	61	68	102	57	238	135	117
Cys	33	33	16	34	80	23	25	24
Asn	76	24	35	194	41	59	81	108
Gln	155	50	95	162	90	114	136	118
Asp	105	11	20	157	12	22	162	176
Glu	155	36	118	342	37	118	205	156
Lys	181	65	43	128	66	288	259	199
Arg	143	33	46	97	7	368	232	165
His	58	26	36	50	35	57	58	58