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Literature for peptidase M10.005: matrix metallopeptidase-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J.
    Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  2. Escriche-Navarro,B., Garrido,E., Sancenon,F., Garcia-Fernandez,A. and Martinez-Manez,R.
    A navitoclax-loaded nanodevice targeting matrix metalloproteinase-3 for the selective elimination of senescent cells
    Acta Biomater176, 405-416. PubMed  Europe PubMed DOI
  3. Zhou,J., Le,C.Q., Zhang,Y. and Wells,J.A.
    A general approach for selection of epitope-directed binders to proteins
    Proc Natl Acad Sci U S A121, e2317307121-e2317307121. PubMed  Europe PubMed DOI
    4. 2023
  4. Bonadio,A., Wenig,B.L., Hockla,A., Radisky,E.S. and Shifman,J.M.
    Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor
    J Mol Biol435, 168095-168095. PubMed  Europe PubMed DOI
    5. 2022
  5. Basia,D., Gupta,M.D., Kunal,S., Muheeb,G., Girish,M.P., Bansal,A., Batra,V., Yusuf,J., Mukhopadhyay,S., Tyagi,S. and Singh,R.
    Matrix metalloproteinases and their gene polymorphism in young ST-segment elevation myocardial infarction
    Indian Heart J74, 519-523. PubMed  Europe PubMed DOI
  6. Bolt,A.J., Do,L.D. and Raeeszadeh-Sarmazdeh,M.
    Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
    J Vis Exp PubMed  Europe PubMed DOI
  7. Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B., Darewicz,B., Bruczko-Goralewska,M. and Romanowicz,L.
    Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma
    Int J Environ Res Public Health19, 12613-12613. PubMed  Europe PubMed DOI
  8. Kumper,M., Zamek,J., Steinkamp,J., Pach,E., Mauch,C. and Zigrino,P.
    Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair
    Eur J Cell Biol101, 151276-151276. PubMed  Europe PubMed DOI
  9. Orlov,E.E., Nesterenko,A.M., Korotkova,D.D., Parshina,E.A., Martynova,N.Y. and Zaraisky,A.G.
    Targeted search for scaling genes reveals matrixmetalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos
    Dev Cell57, 95-111. PubMed  Europe PubMed DOI
  10. Raeeszadeh-Sarmazdeh,M., Coban,M., Mahajan,S., Hockla,A., Sankaran,B., Downey,G.P., Radisky,D.C. and Radisky,E.S.
    Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10
    J Biol Chem298, 101654-101654. PubMed  Europe PubMed DOI
    11. 2021
  11. Bassiouni,W., Ali,M.A.M. and Schulz,R.
    Multifunctional intracellular matrix metalloproteinases: implications in disease
    FEBS J288, 7162-7182. PubMed  Europe PubMed DOI  V
  12. Kadry,R.W., Adil,M.S., Newsome,A.S. and Somanath,P.R.
    Cisatracurium attenuates LPS-induced modulation of MMP3 and junctional protein expression in human microvascular endothelial cells
    Biosci Trends15, 50-54. PubMed  Europe PubMed DOI
  13. Kim,B.Y., Lee,K.S., Lee,K.Y., Yoon,H.J. and Jin,B.R.
    Anti-fibrinolytic activity of a metalloprotease inhibitor from bumblebee (Bombus ignitus) venom
    Comp Biochem Physiol C Toxicol Pharmacol245, 109042-109042. PubMed  Europe PubMed DOI
  14. Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B., Darewicz,B., Bruczko-Goralewska,M., Sobolewski,K. and Romanowicz,L.
    Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma
    J Clin Med10, 3683-3683. PubMed  Europe PubMed DOI
  15. Nakagawa,M., Shirasugi,M., Yamamoto,T., Nakaya,T. and Kanamura,N.
    Long-term exposure to butyric acid induces excessive production of matrix metalloproteases in human gingival fibroblasts
    Arch Oral Biol123, 105035-105035. PubMed  Europe PubMed DOI  L
  16. Shi,S., Su,M., Shen,G., Hu,Y., Yi,F., Zeng,Z., Zhu,P., Yang,G., Zhou,H., Li,Q. and Xie,X.
    Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19
    J Med Virol93, 528-532. PubMed  Europe PubMed DOI
  17. Shivnath,N., Rawat,V., Siddiqui,S., Verma,S., Gupta,P., Rais,J., Khan,M.S. and Arshad,M.
    Antiosteoarthritic effect of Punica granatum L. peel extract on collagenase induced osteoarthritis rat by modulation of COL-2, MMP-3, and COX-2 expression
    Environ Toxicol36, 5-15. PubMed  Europe PubMed DOI
  18. Starikova,D., Ponomarenko,I., Reshetnikov,E., Dvornyk,V. and Churnosov,M.
    Novel data about association of the functionally significant polymorphisms of the MMP-9 gene with exfoliation glaucoma in the Caucasian population of Central Russia
    Ophthalmic Res64, 458-464. PubMed  Europe PubMed DOI
    19. 2020

  19. RETRACTED: Products of dentin matrix protein-1 degradation by interleukin-1beta-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells
    Biosci Trends14, E3-E3. PubMed  Europe PubMed DOI

  20. RETRACTED: Polyphosphate-induced matrix metalloproteinase-3-mediated proliferation in rat dental pulp fibroblast-like cells is mediated by a Wnt5 signaling cascade
    Biosci Trends14, E2-E2. PubMed  Europe PubMed DOI
  21. Azouz,A.A., Saleh,E. and Abo-Saif,A.A.
    Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund's adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway
    Saudi Pharm J28, 1101-1111. PubMed  Europe PubMed DOI  I
  22. Balkhi,S., Mashayekhi,F., Salehzadeh,A. and Saedi,H.S.
    Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and -3 serum concentration and associates with breast cancer
    Mol Biol Rep PubMed  Europe PubMed DOI
  23. Celik,Z.B., Cankara,F.N. and Gunaydin,C.
    Alterations in the matrix metalloproteinase-3 promoter methylation after common chemotherapeutics: in vitro study of paclitaxel, cisplatin and methotrexate in the MCF-7 and SH-SY5Y cell lines
    Mol Biol Rep47, 8987-8995. PubMed  Europe PubMed DOI
  24. Er,A., Coskun,D., Bahcivan,E. and Dik,B.
    Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain
    Iran J Basic Med Sci23, 1328-1334. PubMed  Europe PubMed DOI  I
  25. Frieling,J.S., Li,T., Tauro,M. and Lynch,C.C.
    Prostate cancer-derived MMP-3 controls intrinsic cell growth and extrinsic angiogenesis
    Neoplasia22, 511-521. PubMed  Europe PubMed DOI
  26. Georgiev,T., Ivanova,M., Velikova,T. and Stoilov,R.
    Serum levels of matrix metalloproteinase-3 as a prognostic marker for progression of cartilage injury in patients with knee osteoarthritis
    Acta Reumatol Port45, 207-213. PubMed  Europe PubMed
  27. Jun,E.S., Kim,Y.J., Kim,H.H. and Park,S.Y.
    Gold Nanoparticles Using Ecklonia stolonifera Protect Human Dermal Fibroblasts from UVA-Induced Senescence through Inhibiting MMP-1 and MMP-3
    Mar Drugs18, PubMed  Europe PubMed DOI
  28. Leem,Y.H., Park,J.S., Park,J.E., Kim,D.Y., Kang,J.L. and Kim,H.S.
    Papaverine inhibits alpha-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease
    Biomed Pharmacother130, 110576-110576. PubMed  Europe PubMed DOI
  29. Nishi,K., Gondaira,S., Okamoto,M., Watanabe,R., Hirano,Y., Fujiki,J., Iwano,H. and Higuchi,H.
    Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1beta expression in mononuclear cells
    Vet Immunol Immunopathol227, 110057-110057. PubMed  Europe PubMed DOI
  30. Rong,S., Li,C., Li,S., Wu,S. and Sun,F.
    Genetically-modified adipose-derived stem cells with matrix metalloproteinase 3 promote scarless cutaneous repair
    Dermatol There14112-e14112. PubMed  Europe PubMed DOI
  31. Shi,L., Liang,T., Yang,F., Zhu,F.F., Liu,J., Jiang,J.Q., Wu,X.W., Chen,A.S., Yuan,D.P. and Liang,X.L.
    Matrix Metalloproteinase-3 induces proteoglycan degradation in gouty arthritis model
    Gene765, 145120-145120. PubMed  Europe PubMed DOI
  32. Sowinska,A., Rensing,M., Klevenvall,L., Neog,M., Lundback,P. and Harris,H.E.
    Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions
    Front Immunol11, 448262-448262. PubMed  Europe PubMed DOI
  33. Wang,Q., Notay,K., Downey,G.P. and McCulloch,C.A.
    The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation
    Cell Rep31, 107781-107781. PubMed  Europe PubMed DOI
  34. Warner,S.C., Nair,A., Marpadga,R., Chubinskaya,S., Doherty,M., Valdes,A.M. and Scanzello,C.R.
    IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity
    Front Immunol11, 1385-1385. PubMed  Europe PubMed DOI
  35. Zheng,K., Li,Q., Lin,D., Zong,X., Luo,X., Yang,M., Yue,X. and Ma,S.
    Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites
    Food Funct11, 7481-7494. PubMed  Europe PubMed DOI
    36. 2019
  36. Mirastschijski,U., Dinesh,N., Baskaran,S., Wedekind,D., Gavrilovic,J., Murray,M.Y., Bevan,D. and Kelm,S.
    Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses
    Wound Repair Regen27, 309-323. PubMed  Europe PubMed DOI
    37. 2018
  37. Hafez,S., Abdelsaid,M., Fagan,S.C. and Ergul,A.
    Peroxynitrite-induced tyrosine nitration contributes to matrix metalloprotease-3 activation: relevance to hyperglycemic ischemic brain injury and tissue plasminogen activator
    Neurochem Res43, 259-266. PubMed  Europe PubMed DOI
  38. Siebuhr,A.S., Kjelgaard-Petersen,C.F., Sun,S., Byrjalsen,I., Christiansen,C., Karsdal,M.A. and Bay-Jensen,A.C.
    Suppression of active, but not total MMP-3, is associated with treatment response in a phase III clinical study of rheumatoid arthritis
    Clin Exp Rheumatol36, 94-101. PubMed  Europe PubMed
  39. Wang,K.H., Wang,Y.M., Chiu,L.H., Chen,T.C., Tsai,Y.H., Zuo,C.S., Chen,K.C., Changou,C.A. and Lai,W.T.
    Optical imaging of ovarian cancer using a matrix metalloproteinase-3-sensitive near-infrared fluorescent probe
    PLoS ONE13, e0192047-e0192047. PubMed  Europe PubMed DOI  L
    40. 2017
  40. Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D.
    Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases
    Am J Cancer Res7, 2257-2274. PubMed  Europe PubMed
    41. 2016
  41. Adiguzel,M., Horozoglu,C., Kilicoglu,O., Ozger,H., Acar,L. and Ergen,A.
    MMP-3 gene polymorphisms and osteosarcoma
    Indian J Exp Biol54, 175-179. PubMed  Europe PubMed  M
    42. 2015
  42. Aerts,J., Nys,J., Moons,L., Hu,T.T. and Arckens,L.
    Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice
    Brain Struct Funct220, 2675-2689. PubMed  Europe PubMed DOI  K
  43. Lee,J.Y., Choi,H.Y. and Yune,T.Y.
    MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death
    Neurobiol Dis82, 141-151. PubMed  Europe PubMed DOI
  44. Ma,J. and You,C.
    Association between matrix metalloproteinase-3 gene polymorphism and moyamoya disease
    J Clin Neurosci22, 479-482. PubMed  Europe PubMed DOI  M
    45. 2014
  45. Choi,D.H., Kim,J.H., Seo,J.H., Lee,J., Choi,W.S. and Kim,Y.S.
    Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress
    PLoS ONE9, e115954-e115954. PubMed  Europe PubMed DOI
  46. Feng,Z., He,G., Chen,Z., Wu,Z. and Li,J.
    Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis
    BMC Musculoskelet Disord15, 376-376. PubMed  Europe PubMed DOI  M
  47. Kon,S., Nakayama,Y., Matsumoto,N., Ito,K., Kanayama,M., Kimura,C., Kouro,H., Ashitomi,D., Matsuda,T. and Uede,T.
    A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for alpha9beta1 integrin is involved in the anti-type II collagen antibody-induced arthritis
    PLoS ONE9, e116210-e116210. PubMed  Europe PubMed DOI
  48. Lee,J.Y., Choi,H.Y., Ahn,H.J., Ju,B.G. and Yune,T.Y.
    Matrix metalloproteinase-3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury
    Am J Pathol184, 2985-3000. PubMed  Europe PubMed DOI  I
  49. Maize,K.M., Zhang,X. and Amin,E.A.
    Statistical analysis, optimization, and prioritization of virtual screening parameters for zinc enzymes including the anthrax toxin lethal factor
    Curr Top Med Chem14, 2105-2114. PubMed  Europe PubMed  I
  50. Wen,D., Du,X., Nie,S.P., Dong,J.Z. and Ma,C.S.
    Association Between Matrix Metalloproteinase Family Gene Polymorphisms and Ischemic Stroke: a Meta-analysis
    Mol Neurobiol50, 979-985. PubMed  Europe PubMed DOI  M
    51. 2013
  51. Belviso,B.D., Caliandro,R., Siliqi,D., Calderone,V., Arnesano,F. and Natile,G.
    Structure of matrix metalloproteinase-3 with a platinum-based inhibitor
    Chem Commun (Camb)49, 5492-5494. PubMed  Europe PubMed DOI  S  I
  52. Chao,T., Frump,D., Lin,M., Caiozzo,V.J., Mozaffar,T., Steward,O. and Gupta,R.
    Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury
    Ann Neurol73, 210-223. PubMed  Europe PubMed DOI  K
  53. Furtwangler,T., Chan,S.C., Bahrenberg,G., Richards,P.J. and Gantenbein-Ritter,B.
    Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine Intervertebral disc organ culture model
    Spine (Phila Pa 1976)38, E1377-E1387. PubMed  Europe PubMed DOI
  54. Stegemann,C., Didangelos,A., Barallobre-Barreiro,J., Langley,S.R., Mandal,K., Jahangiri,M. and Mayr,M.
    Proteomic identification of matrix metalloproteinase substrates in the human vasculature
    Circ Cardiovasc Genet6, 106-117. PubMed  Europe PubMed DOI  P
    55. 2012
  55. Ceruso,M., Howe,N. and Malthouse,J.P.
    Mechanism of the binding of Z-L-tryptophan and Z-L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions
    Biochim Biophys Acta1824, 303-310. PubMed  Europe PubMed DOI
  56. Kim,S.K., Kang,S.W., Kim,D.H., Yun,D.H., Chung,J.H. and Ban,J.Y.
    Matrix metalloproteinase-3 gene polymorphisms are associated with ischemic stroke
    J Interferon Cytokine Res32, 81-86. PubMed  Europe PubMed DOI  M
  57. Nagase,H.
    Matrix metalloproteinase 3/stromelysin 1
    [ISSN:978-0-12-407744-7]3, 763-774. DOI
  58. Shin,E.J., Kim,E.M., Lee,J.A., Rhim,H. and Hwang,O.
    Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinson's disease
    Neurochem Int60, 249-256. PubMed  Europe PubMed DOI
  59. Shu,M., Zhang,Y.R., Tian,F.F., Yang,L. and Lin,Z.H.
    Molecular docking and 3D-QSAR research of biphenyl carboxylic acid MMP-3 inhibitors
    Jiegou Huaxue31, 443-451.  I
  60. Van Hove,I., Lemmens,K., Van de Velde,S., Verslegers,M. and Moons,L.
    Matrix metalloproteinase-3 in the central nervous system: a look on the bright side
    J Neurochem123, 203-216. PubMed  Europe PubMed DOI
  61. Van Hove,I., Verslegers,M., Buyens,T., Delorme,N., Lemmens,K., Stroobants,S., Gantois,I., D'Hooge,R. and Moons,L.
    An aberrant cerebellar development in mice lacking matrix metalloproteinase-3
    Mol Neurobiol45, 17-29. PubMed  Europe PubMed DOI  K
  62. Wilfong,E.M., Du,Y. and Toone,E.J.
    An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1
    Bioorg Med Chem Lett22, 6521-6524. PubMed  Europe PubMed DOI  I
    63. 2011
  63. Choi,S.S., Ji,A.R., Yu,S.W., Cho,B.H., Park,J.D., Park,J.H., Lee,H.S., Ryu,S.E., Kim,D.H., Kang,J.H. and Lee,S.T.
    Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors
    Bull Korean Chem Soc32, 2032-2038. DOI  I
  64. Howe,N., Ceruso,M., Spink,E. and Malthouse,J.P.
    pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor
    Biochim Biophys Acta1814, 1394-1403. PubMed  Europe PubMed DOI  I
  65. Yamashita,C.M., Dolgonos,L., Zemans,R.L., Young,S.K., Robertson,J., Briones,N., Suzuki,T., Campbell,M.N., Gauldie,J., Radisky,D.C., Riches,D.W., Yu,G., Kaminski,N., McCulloch,C.A. and Downey,G.P.
    Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis
    Am J Pathol179, 1733-1745. PubMed  Europe PubMed DOI
    66. 2010
  66. Liang,X., Arunima,A., Zhao,Y., Bhaskaran,R., Shende,A., Byrne,T.S., Fleeks,J., Palmier,M.O. and Van Doren,S.R.
    Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3
    Biophys J99, 273-283. PubMed  Europe PubMed DOI
  67. Wilfong,E.M., Locklear,U. and Toone,E.J.
    A single step purification for autolytic zinc proteinases
    Bioorg Med Chem Lett20, 280-282. PubMed  Europe PubMed DOI  E
    68. 2009
  68. Juncker-Jensen,A., Romer,J., Pennington,C.J., Lund,L.R. and Almholt,K.
    Spontaneous metastasis in matrix metalloproteinase 3-deficient mice
    Mol Carcinog48, 618-625. PubMed  Europe PubMed DOI
  69. Sahasrabudhe,P.V. and Stockman,B.J.
    Resonance assignments for stromelysin complexed with a beta-sulfonyl hydroxamate inhibitor
    Biomol NMR Assign3, 183-186. PubMed  Europe PubMed DOI  S  I
    70. 2008
  70. Djuric,T., Zivkovic,M., Stankovic,A., Dincic,E., Raicevic,R. and Alavantic,D.
    Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia
    J Neurol Sci267, 62-65. PubMed  Europe PubMed DOI  M
    71. 2007
  71. Alcaraz,L.A., Banci,L., Bertini,I., Cantini,F., Donaire,A. and Gonnelli,L.
    Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors
    J Biol Inorg Chem12, 1197-1206. PubMed  Europe PubMed DOI  S  I
  72. Kim,Y.S., Choi,D.H., Block,M.L., Lorenzl,S., Yang,L., Kim,Y.J., Sugama,S., Cho,B.P., Hwang,O., Browne,S.E., Kim,S.Y., Hong,J.S., Beal,M.F. and Joh,T.H.
    A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation
    FASEB J21, 179-187. PubMed  Europe PubMed DOI
  73. Oceandy,D., Yusoff,R., Baudoin,F.M., Neyses,L. and Ray,S.G.
    Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients
    Eur J Heart Fail9, 1010-1017. PubMed  Europe PubMed DOI  M
  74. VanSaun,M., Humburg,B.C., Arnett,M.G., Pence,M. and Werle,M.J.
    Activation of matrix metalloproteinase-3 is altered at the frog neuromuscular junction following changes in synaptic activity
    Dev Neurobiol67, 1488-1497. PubMed  Europe PubMed DOI
  75. Whitlock,G.A., Dack,K.N., Dickinson,R.P. and Lewis,M.L.
    A novel series of highly selective inhibitors of MMP-3
    Bioorg Med Chem Lett17, 6750-6753. PubMed  Europe PubMed DOI  I
    76. 2006
  76. Amin,E.A. and Welsh,W.J.
    Highly predictive CoMFA and CoMSIA models for two series of stromelysin-1 (MMP-3) inhibitors elucidate S1' and S1-S2' binding modes
    J Chem Inf Model46, 1775-1783. PubMed  Europe PubMed DOI  I
  77. Chen,C.H., Lin,K.C., Yu,D.T., Yang,C., Huang,F., Chen,H.A., Liang,T.H., Liao,H.T., Tsai,C.Y., Wei,J.C. and Chou,C.T.
    Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity
    Rheumatology (Oxford)45, 414-420. PubMed  Europe PubMed DOI
  78. [YEAR:27-3-2006]Kohno,T., Hochigai,H., Yamashita,E., Tsukihara,T. and Kanaoka,M.
    Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453
    Biochem Biophys Res Commun344, 315-322. PubMed  Europe PubMed DOI  S  I
  79. Si-Tayeb,K., Monvoisin,A., Mazzocco,C., Lepreux,S., Decossas,M., Cubel,G., Taras,D., Blanc,J.F., Robinson,D.R. and Rosenbaum,J.
    Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis
    Am J Pathol169, 1390-1401. PubMed  Europe PubMed DOI  I
    80. 2005
  80. Beilby,J.P., Chapman,C.M., Palmer,L.J., McQuillan,B.M., Thompson,P.L. and Hung,J.
    Stromelysin-1 (MMP-3) gene 5A/6A promoter polymorphism is associated with blood pressure in a community population
    J Hypertens23, 537-542. PubMed  Europe PubMed
  81. [YEAR:6-4-2005]Kim,Y.S., Kim,S.S., Cho,J.J., Choi,D.H., Hwang,O., Shin,D.H., Chun,H.S., Beal,M.F. and Joh,T.H.
    Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia
    J Neurosci25, 3701-3711. PubMed  Europe PubMed DOI  I
  82. Mora,B., Bonamico,M., Ferri,M., Megiorni,F., Osborn,J., Pizzuti,A. and Mazzilli,M.C.
    Association of the matrix metalloproteinase-3 (MMP-3) promoter polymorphism with celiac disease in male subjects
    Hum Immunol66, 716-720. PubMed  Europe PubMed DOI
  83. [YEAR:4-4-2005]Sani,M., Candiani,G., Pecker,F., Malpezzi,L. and Zanda,M.
    Novel highly potent, structurally simple gamma-trifluoromethyl gamma-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3)
    Tetrahedron Lett46, 2393-2396.  I
    84. 2004
  84. [YEAR:15-10-2004]Li,C.K., Pender,S.L., Pickard,K.M., Chance,V., Holloway,J.A., Huett,A., Goncalves,N.S., Mudgett,J.S., Dougan,G., Frankel,G. and Macdonald,T.T.
    Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice
    J Immunol173, 5171-5179. PubMed  Europe PubMed
  85. Nagase,H.
    Stromelysin 1
    [ISSN:0-12-079610-4]2, 512-523.  V
    86. 2003
  86. Arumugam,S. and Van Doren,S.R.
    Global orientation of bound MMP-3 and N-TIMP-1 in solution via residual dipolar couplings
    Biochemistry42, 7950-7958. PubMed  Europe PubMed DOI  S
    87. 2002
  87. [YEAR:1-4-2002]Gearing,A.J., Thorpe,S.J., Miller,K., Mangan,M., Varley,P.G., Dudgeon,T., Ward,G., Turner,C. and Thorpe,R.
    Selective cleavage of human IgG by the matrix metalloproteinases, matrilysin and stromelysin
    Immunol Lett81, 41-48. PubMed  Europe PubMed DOI
  88. [YEAR:12-12-2002]Yamada,Y., Izawa,H., Ichihara,S., Takatsu,F., Ishihara,H., Hirayama,H., Sone,T., Tanaka,M. and Yokota,M.
    Prediction of the risk of myocardial infarction from polymorphisms in candidate genes
    N Engl J Med347, 1916-1923. PubMed  Europe PubMed DOI  M
    89. 2001
  89. [YEAR:27-7-2001]Agnihotri,R., Crawford,H.C., Haro,H., Matrisian,L.M., Havrda,M.C. and Liaw,L.
    Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)
    J Biol Chem276, 28261-28267. PubMed  Europe PubMed DOI
  90. [YEAR:19-2-2001]Alexander,C.M., Selvarajan,S., Mudgett,J. and Werb,Z.
    Stromelysin-1 regulates adipogenesis during mammary gland involution
    J Cell Biol152, 693-703. PubMed  Europe PubMed DOI
  91. Arza,B., De Maeyer,M., Felez,J., Collen,D. and Lijnen,H.R.
    Critical role of glutamic acid 202 in the enzymatic activity of stromelysin-1 (MMP-3)
    Eur J Biochem268, 826-831. PubMed  Europe PubMed DOI
  92. Dunten,P., Kammlott,U., Crowther,R., Levin,W., Foley,L.H., Wang,P. and Palermo,R.
    X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin
    Protein Sci10, 923-926. PubMed  Europe PubMed DOI  S  I
  93. Fray,M.J., Burslem,M.F. and Dickinson,R.P.
    Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality
    Bioorg Med Chem Lett11, 567-570. PubMed  Europe PubMed DOI  I
  94. [YEAR:11-6-2001]Lijnen,H.R., Van Hoef,B. and Collen,D.
    Inactivation of the serpin alpha(2)-antiplasmin by stromelysin-1
    Biochim Biophys Acta1547, 206-213. PubMed  Europe PubMed DOI
  95. Pikul,S., Dunham,K.M., Almstead,N.G., De,B., Natchus,M.G., Taiwo,Y.O., Williams,L.E., Hynd,B.A., Hsieh,L.C., Janusz,M.J., Gu,F. and Mieling,G.E.
    Heterocycle-based MMP inhibitors with P2' substituents
    Bioorg Med Chem Lett11, 1009-1013. PubMed  Europe PubMed DOI  S  I
  96. Satsangi,J., Chapman,R.W., Haldar,N., Donaldson,P., Mitchell,S., Simmons,J., Norris,S., Marshall,S.E., Bell,J.I., Jewell,D.P. and Welsh,K.I.
    A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis
    Gastroenterology121, 124-130. PubMed  Europe PubMed  M
  97. Stix,B., Kahne,T., Sletten,K., Raynes,J., Roessner,A. and Rocken,C.
    Proteolysis of AA amyloid fibril proteins by matrix metalloproteinases-1, -2, and -3
    Am J Pathol159, 561-570. PubMed  Europe PubMed DOI
  98. Warner,R.L., Beltran,L., Younkin,E.M., Lewis,C.S., Weiss,S.J., Varani,J. and Johnson,K.J.
    Role of stromelysin 1 and gelatinase B in experimental acute lung injury
    Am J Respir Cell Mol Biol24, 537-544. PubMed  Europe PubMed DOI  K
    99. 2000
  99. Cheng,M., De,B., Pikul,S., Almstead,N.G., Natchus,M.G., Anastasio,M.V., McPhail,S.J., Snider,C.E., Taiwo,Y.O., Chen,L., Dunaway,C.M., Gu,F., Dowty,M.E., Mieling,G.E., Janusz,M.J. and Wang-Weigand,S.
    Design and synthesis of piperazine-based matrix metalloproteinase inhibitors
    J Med Chem43, 369-380. PubMed  Europe PubMed DOI  S  I
  100. Natchus,M.G., Bookland,R.G., De,B., Almstead,N.G., Pikul,S., Janusz,M.J., Heitmeyer,S.A., Hookfin,E.B., Hsieh,L.C., Dowty,M.E., Dietsch,C.R., Patel,V.S., Garver,S.M., Gu,F., Pokross,M.E., Mieling,G.E., Baker,T.R., Foltz,D.J., Peng,S.X., Bornes,D.M., Strojnowski,M.J. and Taiwo,Y.O.
    Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines
    J Med Chem43, 4948-4963. PubMed  Europe PubMed DOI  S  I
  101. Steele,D.L., El-Kabbani,O., Dunten,P., Windsor,L.J., Kammlott,R.U., Crowther,R.L., Michoud,C., Engler,J.A. and Birktoft,J.J.
    Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1
    Protein Eng13, 397-405. PubMed  Europe PubMed
    102. 1999
  102. Almstead,N.G., Bradley,R.S., Pikul,S., De,B., Natchus,M.G., Taiwo,Y.O., Gu,F., Williams,L.E., Hynd,B.A., Janusz,M.J., Dunaway,C.M. and Mieling,G.E.
    Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors
    J Med Chem42, 4547-4562. PubMed  Europe PubMed DOI  I
  103. Bullard,K.M., Lund,L., Mudgett,J.S., Mellin,T.N., Hunt,T.K., Murphy,B., Ronan,J., Werb,Z. and Banda,M.J.
    Impaired wound contraction in stromelysin-1-deficient mice
    Ann Surg230, 260-265. PubMed  Europe PubMed DOI  K
  104. [YEAR:1-6-1999]Bullard,K.M., Mudgett,J., Scheuenstuhl,H., Hunt,T.K. and Banda,M.J.
    Stromelysin-1-deficient fibroblasts display impaired contraction in vitro
    J Surg Res84, 31-34. PubMed  Europe PubMed DOI  K
  105. [YEAR:29-10-1999]Chen,L., Rydel,T.J., Gu,F., Dunaway,C.M., Pikul,S., Dunham,K.M. and Barnett,B.L.
    Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes
    J Mol Biol293, 545-557. PubMed  Europe PubMed DOI  S  I
  106. Cheng,M., De,B., Almstead,N.G., Pikul,S., Dowty,M.E., Dietsch,C.R., Dunaway,C.M., Gu,F., Hsieh,L.C., Janusz,M.J., Taiwo,Y.O., Natchus,M.G., Hudlicky,T. and Mandel,M.
    Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold
    J Med Chem42, 5426-5436. PubMed  Europe PubMed DOI  S  I
  107. [YEAR:12-1-1999]Holman,C.M., Kan,C.C., Gehring,M.R. and Van Wart,H.E.
    Role of His-224 in the anomalous pH dependence of human stromelysin-1
    Biochemistry38, 677-681. PubMed  Europe PubMed DOI
  108. [YEAR:12-10-1999]Parker,M.H., Lunney,E.A., Ortwine,D.F., Pavlovsky,A.G., Humblet,C. and Brouillette,C.G.
    Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry
    Biochemistry38, 13592-13601. PubMed  Europe PubMed DOI  I
  109. Pavlovsky,A.G., Williams,M.G., Ye,Q.Z., Ortwine,D.F., Purchase,C.F., White,A.D., Dhanaraj,V., Roth,B.D., Johnson,L.L., Hupe,D., Humblet,C. and Blundell,T.L.
    X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity
    Protein Sci8, 1455-1462. PubMed  Europe PubMed DOI  S  I
  110. [YEAR:23-7-1999]Sternlicht,M.D., Lochter,A., Sympson,C.J., Huey,B., Rougier,J.P., Gray,J.W., Pinkel,D., Bissell,M.J. and Werb,Z.
    The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
    Cell98, 137-146. PubMed  Europe PubMed DOI
  111. van Meurs,J., van Lent,P., Holthuysen,A., Lambrou,D., Bayne,E., Singer,I. and Van den Berg,W.
    Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction
    J Immunol163, 5633-5639. PubMed  Europe PubMed
  112. van Meurs,J., van Lent,P., Stoop,R., Holthuysen,A., Singer,I., Bayne,E., Mudgett,J., Poole,R., Billinghurst,C., Van der Kraan,P., Buma,P. and Van den Berg,W.
    Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity
    Arthritis Rheum42, 2074-2084. PubMed  Europe PubMed DOI
  113. Wang,M., Qin,X., Mudgett,J.S., Ferguson,T.A., Senior,R.M. and Welgus,H.G.
    Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response
    Proc Natl Acad Sci U S A96, 6885-6889. PubMed  Europe PubMed DOI  K
    114. 1998
  114. del Mar Barbacid,M., Fernandez-Resa,P., Buesa,J.M., Marquez,G., Aracil,M., Quesadaand,A.R. and Mira,E.
    Expression and purification of human stromelysin 1 and 3 from baculovirus-infected insect cells
    Protein Expr Purif13, 243-250. PubMed  Europe PubMed DOI
  115. Finzel,B.C., Baldwin,E.T., Bryant,G.L., Jr., Hess,G.F., Wilks,J.W., Trepod,C.M., Mott,J.E., Marshall,V.P., Petzold,G.L., Poorman,R.A., O'Sullivan,T.J., Schostarez,H.J. and Mitchell,M.A.
    Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity
    Protein Sci7, 2118-2126. PubMed  Europe PubMed DOI  S  I
  116. Kozaci,L.D., Brown,C.J., Adcocks,C., Galloway,A., Hollander,A.P. and Buttle,D.J.
    Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown
    J Clin Pathol Mol Pathol51, 282-286. PubMed  Europe PubMed
  117. [YEAR:7-4-1998]Lijnen,H.R., Ugwu,F., Bini,A. and Collen,D.
    Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3)
    Biochemistry37, 4699-4702. PubMed  Europe PubMed DOI
  118. Mudgett,J.S., Hutchinson,N.I., Chartrain,N.A., Forsyth,A.J., McDonnell,J., Singer,I.I., Bayne,E.K., Flanagan,J., Kawka,D., Shen,C.F., Stevens,K., Chen,H., Trumbauer,M. and Visco,D.M.
    Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction
    Arthritis Rheum41, 110-121. PubMed  Europe PubMed DOI  K
  119. Suzuki,K., Kan,C.C., Hung,W., Gehring,M.R., Brew,K. and Nagase,H.
    Expression of human pro-matrix metalloproteinase 3 that lacks the N-terminal 34 residues in Escherichia coli: autoactivation and interaction with tissue inhibitor of metalloproteinase 1 (TIMP-1)
    Biol Chem379, 185-191. PubMed  Europe PubMed
  120. [YEAR:18-6-1998]Towle,C.A., Wright,M., Hecht,A.C., Kuong,S.J., Papanicolas,L.E., Totkovic,R., Mankin,H.J. and Treadwell,B.V.
    A matrix metalloproteinase proenzyme activator produced by articular cartilage
    Biochem Biophys Res Commun247, 324-331. PubMed  Europe PubMed DOI
  121. [YEAR:19-5-1998]Ugwu,F., Van Hoef,B., Bini,A., Collen,D. and Lijnen,H.R.
    Proteolytic cleavage of urokinase-type plasminogen activator by stromelysin-1 (MMP-3)
    Biochemistry37, 7231-7236. PubMed  Europe PubMed DOI
    122. 1997
  122. [YEAR:1-12-1997]Beekman,B., van El,B., Drijfhout,J.W., Ronday,H.K. and TeKoppele,J.M.
    Highly increased levels of active stromelysin in rheumatoid synovial fluid determined by a selective fluorogenic assay
    FEBS Lett418, 305-309. PubMed  Europe PubMed DOI  A
  123. Cherney,R.J., Decicco,C.P., Nelson,D.J., Wang,L., Meyer,D.T., Hardman,K.D., Copeland,R.A. and Arner,E.C.
    Potent carboxylate inhibitors of stromelysin containing P2' piperazic acids and P1' biaryl moeities
    Bioorg Med Chem Lett7, 1757-1762.  I
  124. Esser,C.K., Bugianesi,R.L., Caldwell,C.G., Chapman,K.T., Durette,P.L., Girotra,N.N., Kopka,I.E., Lanza,T.J., Levorse,D.A., MacCross,M., Owens,K.A., Ponpipom,M.M., Simeone,J.P., Harrison,R.K., Niedzwiecki,L., Becker,J.W., Marcy,A.I., Axel,M.G., Christen,A.J., McDonnell,J., Moore,V.L., Olszewski,J.M., Saphos,C., Visco,D.M. and Hagmann,W.K.
    Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides
    J Med Chem40, 1026-1040. PubMed  Europe PubMed DOI  S  I
  125. [YEAR:4-9-1997]Gomis-Ruth,F.X., Maskos,K., Betz,M., Bergner,A., Huber,R., Suzuki,K., Yoshida,N., Nagase,H., Brew,K., Bourenkov,G.P., Bartunik,H. and Bode,W.
    Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1
    Nature389, 77-81. PubMed  Europe PubMed DOI  S
  126. Gonnella,N.C., Li,Y.C., Zhang,X. and Paris,C.G.
    Bioactive conformation of a potent stromelysin inhibitor determined by X-nucleus filtered and multidimensional NMR spectroscopy
    Bioorg Med Chem5, 2193-2201. PubMed  Europe PubMed DOI  I
  127. MacPherson,L.J., Bayburt,E.K., Capparelli,M.P., Carroll,B.J., Goldstein,R., Justice,M.R., Zhu,L., Hu,S., Melton,R.A., Fryer,L., Goldberg,R.L., Doughty,J.R., Spirito,S., Blancuzzi,V., Wilson,D., O'Byrne,E.M., Ganu,V. and Parker,D.T.
    Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits
    J Med Chem40, 2525-2532. PubMed  Europe PubMed DOI  I
  128. Nagase,H., Suzuki,K., Cawston,T.E. and Brew,K.
    Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1)
    Biochem J325, 163-167. PubMed  Europe PubMed
  129. Quesada,A.R., Barbacid,M.M., Mira,E., Fernandez-Resa,P., Marquez,G. and Aracil,M.
    Evaluation of fluorometric and zymographic methods as activity assays for stromelysins and gelatinases
    Clin Exp Metastasis15, 26-32. PubMed  Europe PubMed DOI  A
  130. Rudolph-Owen,L.A., Hulboy,D.L., Wilson,C.L., Mudgett,J. and Matrisian,L.M.
    Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice
    Endocrinology138, 4902-4911. PubMed  Europe PubMed DOI  K
  131. Windsor,L.J., Steele,D.L., LeBlanc,S.B. and Taylor,K.B.
    Catalytic domain comparisons of human fibroblast-type collagenase, stromelysin-1, and matrilysin
    Biochim Biophys Acta1334, 261-272. PubMed  Europe PubMed DOI
    132. 1996
  132. Benbow,U., Buttice,G., Nagase,H. and Kurkinen,M.
    Characterization of the 46-kDa intermediates of matrix metalloproteinase 3 (stromelysin 1) obtained by site-directed mutation of phenylalanine 83
    J Biol Chem271, 10715-10722. PubMed  Europe PubMed DOI
  133. Bini,A., Itoh,Y., Kudryk,B.J. and Nagase,H.
    Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405 peptide bond
    Biochemistry35, 13056-13063. PubMed  Europe PubMed DOI  P
  134. Dhanaraj,V., Ye,Q.Z., Johnson,L.L., Hupe,D.J., Ortwine,D.F., Dunbar,J.B., Jr., Rubin,J.R., Pavlovsky,A., Humblet,C. and Blundell,T.L.
    X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily
    Structure4, 375-386. PubMed  Europe PubMed  S  I
  135. Welch,A.R., Holman,C.M., Huber,M., Brenner,M.C., Browner,M.F. and Van Wart,H.E.
    Understanding the P1' specificity of the matrix metalloproteinases: Effect of S1' pocket mutations in matrilysin and stromelysin- 1
    Biochemistry35, 10103-10109. PubMed  Europe PubMed DOI
    136. 1995
  136. Becker,J.W., Marcy,A.I., Rokosz,L.L., Axel,M.G., Burbaum,J.J., Fitzgerald,P.M., Cameron,P.M., Esser,C.K., Hagmann,W.K. and Hermes,J.D.
    Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme
    Protein Sci4, 1966-1976. PubMed  Europe PubMed DOI  S
  137. Nagase,H.
    Human stromelysins 1 and 2
    Methods Enzymol248, 449-470. PubMed  Europe PubMed DOI  V
    138. 1994
  138. [YEAR:29-4-1994]Baragi,V.M., Fliszar,C.J., Conroy,M.C., Ye,Q.Z., Shipley,J.M. and Welgus,H.G.
    Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin
    J Biol Chem269, 12692-12697. PubMed  Europe PubMed
  139. [YEAR:14-10-1994]Fowlkes,J.L., Enghild,J.J., Suzuki,K. and Nagase,H.
    Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures
    J Biol Chem269, 25742-25746. PubMed  Europe PubMed  P
  140. [YEAR:19-8-1994]Nagase,H., Fields,C.G. and Fields,G.B.
    Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3)
    J Biol Chem269, 20952-20957. PubMed  Europe PubMed
  141. Nguyen,Q., Willenbrock,F., Cockett,M.I., O'Shea,M., Docherty,A.J. and Murphy,G.
    Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A
    Biochemistry33, 2089-2095. PubMed  Europe PubMed
  142. Soler,D., Nomizu,T., Brown,W.E., Chen,M., Ye,Q.Z., Van Wart,H.E. and Auld,D.S.
    Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain
    Biochem Biophys Res Commun201, 917-923. PubMed  Europe PubMed DOI
  143. [YEAR:2-3-1994]Zhang,Z., Winyard,P.G., Chidwick,K., Murphy,G., Wardell,M., Carrell,R.W. and Blake,D.R.
    Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin
    Biochim Biophys Acta1199, 224-228. PubMed  Europe PubMed DOI
    144. 1993
  144. [YEAR:5-10-1993]Chen,L.C., Noelken,M.E. and Nagase,H.
    Disruption of the cysteine-75 and zinc ion coordination is not sufficient to activate the precursor of human matrix metalloproteinase 3 (stromelysin 1)
    Biochemistry32, 10289-10295. PubMed  Europe PubMed DOI
  145. Formstone,C.J., Byrd,P.J., Ambrose,H.J., Riley,J.H., Hernandez,D., McConville,C.M. and Taylor,A.M.
    The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23
    Genomics16, 289-291. PubMed  Europe PubMed DOI
  146. [YEAR:15-8-1993]Windsor,L.J., Grenett,H., Birkedal-Hansen,B., Bodden,M.K., Engler,J.A. and Birkedal-Hansen,H.
    Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters
    J Biol Chem268, 17341-17347. PubMed  Europe PubMed
    147. 1992
  147. Hammani,K., Henriet,P. and Eeckhout,Y.
    Cloning and sequencing of a cDNA encoding mouse stromelysin 1
    Gene120, 321-322. PubMed  Europe PubMed DOI
  148. Ogata,Y., Enghild,J.J. and Nagase,H.
    Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9
    J Biol Chem267, 3581-3584. PubMed  Europe PubMed
  149. Ye,Q.Z., Johnson,L.L., Hupe,D.J. and Baragi,V.
    Purification and characterization of the human stromelysin catalytic domain expressed in Escherichia coli
    Biochemistry31, 11231-11235. PubMed  Europe PubMed DOI  E
    150. 1991
  150. Fosang,A.J., Neame,P.J., Hardingham,T.E., Murphy,G. and Hamilton,J.A.
    Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins
    J Biol Chem266, 15579-15582. PubMed  Europe PubMed
  151. Mast,A.E., Enghild,J.J., Nagase,H., Suzuki,K., Pizzo,S.V. and Salvesen,G.
    Kinetics and physiologic relevance of the inactivation of alpha1- proteinase inhibitor, alpha1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)
    J Biol Chem266, 15810-15816. PubMed  Europe PubMed
  152. Woessner,J.F., Jr.
    Matrix metalloproteinases and their inhibitors in connective tissue remodeling
    FASEB J5, 2145-2154. PubMed  Europe PubMed
    153. 1990
  153. Docherty,A.J. and Murphy,G.
    The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins
    Ann Rheum Dis49 Suppl 1, 469-479. PubMed  Europe PubMed
  154. Emonard,H. and Grimaud,J.A.
    Matrix metalloproteinases. A review
    Cell Mol Biol36, 131-153. PubMed  Europe PubMed
  155. [YEAR:19-6-1990]Nagase,H., Enghild,J.J., Suzuki,K. and Salvesen,G.
    Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate
    Biochemistry29, 5783-5789. PubMed  Europe PubMed DOI
  156. Suzuki,K., Enghild,J.J., Morodomi,T., Salvesen,G. and Nagase,H.
    Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)
    Biochemistry29, 10261-10270. PubMed  Europe PubMed
    157. 1989
  157. Enghild,J.J., Salvesen,G., Brew,K. and Nagase,H.
    Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites
    J Biol Chem264, 8779-8785. PubMed  Europe PubMed
  158. Nicholson,R., Murphy,G. and Breathnach,R.
    Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases
    Biochemistry28, 5195-5203. PubMed  Europe PubMed
  159. Teahan,J., Harrison,R., Izquierdo,M. and Stein,R.L.
    Substrate specificity of human fibroblast stromelysin. Hydrolysis of substance P and its analogues
    Biochemistry28, 8497-8501. PubMed  Europe PubMed  P
    160. 1987
  160. Wilhelm,S.M., Collier,I.E., Kronberger,A., Eisen,A.Z., Marmer,B.L., Grant,G.A., Bauer,E.A. and Goldberg,G.I.
    Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells
    Proc Natl Acad Sci U S A84, 6725-6729. PubMed  Europe PubMed
    161. 1986
  161. Matrisian,L.M., Bowden,G.T., Krieg,P., Furstenberger,G., Briand,J.P., Leroy,P. and Breathnach,R.
    The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors
    Proc Natl Acad Sci U S A83, 9413-9417. PubMed  Europe PubMed
  162. Murphy,G., Hembry,R.M. and Reynolds,J.J.
    Characterization of a specific antiserum to rabbit stromelysin and demonstration of the synthesis of collagenase and stromelysin by stimulated rabbit articular chondrocytes
    Coll Relat Res6, 351-363. PubMed  Europe PubMed
  163. Okada,Y., Nagase,H. and Harris,E.D., Jr.
    A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization
    J Biol Chem261, 14245-14255. PubMed  Europe PubMed
    164. 1985
  164. Chin,J.R., Murphy,G. and Werb,Z.
    Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates
    J Biol Chem260, 12367-12376. PubMed  Europe PubMed

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