Literature for peptidase M10.005: matrix metallopeptidase-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Sato,A., Takagi,K., Yamaguchi-Tanaka,M., Okushima,J., Yamazaki,Y., Ito,A. and Suzuki,T. Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer Exp Mol Pathol (2025) 141, 104954-104954. PubMed Europe PubMed DOI

2024

Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J. Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC
Escriche-Navarro,B., Garrido,E., Sancenon,F., Garcia-Fernandez,A. and Martinez-Manez,R. A navitoclax-loaded nanodevice targeting matrix metalloproteinase-3 for the selective elimination of senescent cells Acta Biomater (2024) 176, 405-416. PubMed Europe PubMed DOI
Zhou,J., Le,C.Q., Zhang,Y. and Wells,J.A. A general approach for selection of epitope-directed binders to proteins Proc Natl Acad Sci U S A (2024) 121, e2317307121-e2317307121. PubMed Europe PubMed DOI PMC EPMC

2023

Bonadio,A., Wenig,B.L., Hockla,A., Radisky,E.S. and Shifman,J.M. Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor J Mol Biol (2023) 435, 168095-168095. PubMed Europe PubMed DOI PMC EPMC

2022

Basia,D., Gupta,M.D., Kunal,S., Muheeb,G., Girish,M.P., Bansal,A., Batra,V., Yusuf,J., Mukhopadhyay,S., Tyagi,S. and Singh,R. Matrix metalloproteinases and their gene polymorphism in young ST-segment elevation myocardial infarction Indian Heart J (2022) 74, 519-523. PubMed Europe PubMed DOI PMC EPMC
Bolt,A.J., Do,L.D. and Raeeszadeh-Sarmazdeh,M. Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography J Vis Exp (2022) PubMed Europe PubMed DOI
Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B., Darewicz,B., Bruczko-Goralewska,M. and Romanowicz,L. Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma Int J Environ Res Public Health (2022) 19, 12613-12613. PubMed Europe PubMed DOI PMC EPMC
Kumper,M., Zamek,J., Steinkamp,J., Pach,E., Mauch,C. and Zigrino,P. Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair Eur J Cell Biol (2022) 101, 151276-151276. PubMed Europe PubMed DOI
Orlov,E.E., Nesterenko,A.M., Korotkova,D.D., Parshina,E.A., Martynova,N.Y. and Zaraisky,A.G. Targeted search for scaling genes reveals matrixmetalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos Dev Cell (2022) 57, 95-111. PubMed Europe PubMed DOI
Raeeszadeh-Sarmazdeh,M., Coban,M., Mahajan,S., Hockla,A., Sankaran,B., Downey,G.P., Radisky,D.C. and Radisky,E.S. Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10 J Biol Chem (2022) 298, 101654-101654. PubMed Europe PubMed DOI PMC EPMC

2021

Bassiouni,W., Ali,M.A.M. and Schulz,R. Multifunctional intracellular matrix metalloproteinases: implications in disease FEBS J (2021) 288, 7162-7182. PubMed Europe PubMed DOI V
Kadry,R.W., Adil,M.S., Newsome,A.S. and Somanath,P.R. Cisatracurium attenuates LPS-induced modulation of MMP3 and junctional protein expression in human microvascular endothelial cells Biosci Trends (2021) 15, 50-54. PubMed Europe PubMed DOI
Kim,B.Y., Lee,K.S., Lee,K.Y., Yoon,H.J. and Jin,B.R. Anti-fibrinolytic activity of a metalloprotease inhibitor from bumblebee (Bombus ignitus) venom Comp Biochem Physiol C Toxicol Pharmacol (2021) 245, 109042-109042. PubMed Europe PubMed DOI
Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B., Darewicz,B., Bruczko-Goralewska,M., Sobolewski,K. and Romanowicz,L. Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma J Clin Med (2021) 10, 3683-3683. PubMed Europe PubMed DOI PMC EPMC
Nakagawa,M., Shirasugi,M., Yamamoto,T., Nakaya,T. and Kanamura,N. Long-term exposure to butyric acid induces excessive production of matrix metalloproteases in human gingival fibroblasts Arch Oral Biol (2021) 123, 105035-105035. PubMed Europe PubMed DOI L
Shi,S., Su,M., Shen,G., Hu,Y., Yi,F., Zeng,Z., Zhu,P., Yang,G., Zhou,H., Li,Q. and Xie,X. Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19 J Med Virol (2021) 93, 528-532. PubMed Europe PubMed DOI PMC EPMC
Shivnath,N., Rawat,V., Siddiqui,S., Verma,S., Gupta,P., Rais,J., Khan,M.S. and Arshad,M. Antiosteoarthritic effect of Punica granatum L. peel extract on collagenase induced osteoarthritis rat by modulation of COL-2, MMP-3, and COX-2 expression Environ Toxicol (2021) 36, 5-15. PubMed Europe PubMed DOI
Starikova,D., Ponomarenko,I., Reshetnikov,E., Dvornyk,V. and Churnosov,M. Novel data about association of the functionally significant polymorphisms of the MMP-9 gene with exfoliation glaucoma in the Caucasian population of Central Russia Ophthalmic Res (2021) 64, 458-464. PubMed Europe PubMed DOI

2020

RETRACTED: Polyphosphate-induced matrix metalloproteinase-3-mediated proliferation in rat dental pulp fibroblast-like cells is mediated by a Wnt5 signaling cascade Biosci Trends (2020) 14, E2-E2. PubMed Europe PubMed DOI
RETRACTED: Products of dentin matrix protein-1 degradation by interleukin-1beta-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells Biosci Trends (2020) 14, E3-E3. PubMed Europe PubMed DOI
Azouz,A.A., Saleh,E. and Abo-Saif,A.A. Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund's adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway Saudi Pharm J (2020) 28, 1101-1111. PubMed Europe PubMed DOI PMC EPMC I
Balkhi,S., Mashayekhi,F., Salehzadeh,A. and Saedi,H.S. Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and -3 serum concentration and associates with breast cancer Mol Biol Rep (2020) PubMed Europe PubMed DOI
Celik,Z.B., Cankara,F.N. and Gunaydin,C. Alterations in the matrix metalloproteinase-3 promoter methylation after common chemotherapeutics: in vitro study of paclitaxel, cisplatin and methotrexate in the MCF-7 and SH-SY5Y cell lines Mol Biol Rep (2020) 47, 8987-8995. PubMed Europe PubMed DOI
Er,A., Coskun,D., Bahcivan,E. and Dik,B. Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain Iran J Basic Med Sci (2020) 23, 1328-1334. PubMed Europe PubMed DOI PMC EPMC I
Frieling,J.S., Li,T., Tauro,M. and Lynch,C.C. Prostate cancer-derived MMP-3 controls intrinsic cell growth and extrinsic angiogenesis Neoplasia (2020) 22, 511-521. PubMed Europe PubMed DOI PMC EPMC
Georgiev,T., Ivanova,M., Velikova,T. and Stoilov,R. Serum levels of matrix metalloproteinase-3 as a prognostic marker for progression of cartilage injury in patients with knee osteoarthritis Acta Reumatol Port (2020) 45, 207-213. PubMed Europe PubMed
Jun,E.S., Kim,Y.J., Kim,H.H. and Park,S.Y. Gold Nanoparticles Using Ecklonia stolonifera Protect Human Dermal Fibroblasts from UVA-Induced Senescence through Inhibiting MMP-1 and MMP-3 Mar Drugs (2020) 18 PubMed Europe PubMed DOI
Leem,Y.H., Park,J.S., Park,J.E., Kim,D.Y., Kang,J.L. and Kim,H.S. Papaverine inhibits alpha-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease Biomed Pharmacother (2020) 130, 110576-110576. PubMed Europe PubMed DOI
Nishi,K., Gondaira,S., Okamoto,M., Watanabe,R., Hirano,Y., Fujiki,J., Iwano,H. and Higuchi,H. Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1beta expression in mononuclear cells Vet Immunol Immunopathol (2020) 227, 110057-110057. PubMed Europe PubMed DOI
Rong,S., Li,C., Li,S., Wu,S. and Sun,F. Genetically-modified adipose-derived stem cells with matrix metalloproteinase 3 promote scarless cutaneous repair Dermatol Ther (2020) , e14112-e14112. PubMed Europe PubMed DOI
Shi,L., Liang,T., Yang,F., Zhu,F.F., Liu,J., Jiang,J.Q., Wu,X.W., Chen,A.S., Yuan,D.P. and Liang,X.L. Matrix Metalloproteinase-3 induces proteoglycan degradation in gouty arthritis model Gene (2020) 765, 145120-145120. PubMed Europe PubMed DOI
Sowinska,A., Rensing,M., Klevenvall,L., Neog,M., Lundback,P. and Harris,H.E. Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions Front Immunol (2020) 11, 448262-448262. PubMed Europe PubMed DOI PMC EPMC
Wang,Q., Notay,K., Downey,G.P. and McCulloch,C.A. The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation Cell Rep (2020) 31, 107781-107781. PubMed Europe PubMed DOI
Warner,S.C., Nair,A., Marpadga,R., Chubinskaya,S., Doherty,M., Valdes,A.M. and Scanzello,C.R. IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity Front Immunol (2020) 11, 1385-1385. PubMed Europe PubMed DOI PMC EPMC
Zheng,K., Li,Q., Lin,D., Zong,X., Luo,X., Yang,M., Yue,X. and Ma,S. Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites Food Funct (2020) 11, 7481-7494. PubMed Europe PubMed DOI

2019

Mirastschijski,U., Dinesh,N., Baskaran,S., Wedekind,D., Gavrilovic,J., Murray,M.Y., Bevan,D. and Kelm,S. Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses Wound Repair Regen (2019) 27, 309-323. PubMed Europe PubMed DOI

2018

Hafez,S., Abdelsaid,M., Fagan,S.C. and Ergul,A. Peroxynitrite-induced tyrosine nitration contributes to matrix metalloprotease-3 activation: relevance to hyperglycemic ischemic brain injury and tissue plasminogen activator Neurochem Res (2018) 43, 259-266. PubMed Europe PubMed DOI
Siebuhr,A.S., Kjelgaard-Petersen,C.F., Sun,S., Byrjalsen,I., Christiansen,C., Karsdal,M.A. and Bay-Jensen,A.C. Suppression of active, but not total MMP-3, is associated with treatment response in a phase III clinical study of rheumatoid arthritis Clin Exp Rheumatol (2018) 36, 94-101. PubMed Europe PubMed
Wang,K.H., Wang,Y.M., Chiu,L.H., Chen,T.C., Tsai,Y.H., Zuo,C.S., Chen,K.C., Changou,C.A. and Lai,W.T. Optical imaging of ovarian cancer using a matrix metalloproteinase-3-sensitive near-infrared fluorescent probe PLoS ONE (2018) 13, e0192047-e0192047. PubMed Europe PubMed DOI L

2017

Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D. Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases Am J Cancer Res (2017) 7, 2257-2274. PubMed Europe PubMed PMC EPMC

2016

Adiguzel,M., Horozoglu,C., Kilicoglu,O., Ozger,H., Acar,L. and Ergen,A. MMP-3 gene polymorphisms and osteosarcoma Indian J Exp Biol (2016) 54, 175-179. PubMed Europe PubMed M

2015

Aerts,J., Nys,J., Moons,L., Hu,T.T. and Arckens,L. Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice Brain Struct Funct (2015) 220, 2675-2689. PubMed Europe PubMed DOI K
Lee,J.Y., Choi,H.Y. and Yune,T.Y. MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death Neurobiol Dis (2015) 82, 141-151. PubMed Europe PubMed DOI
Ma,J. and You,C. Association between matrix metalloproteinase-3 gene polymorphism and moyamoya disease J Clin Neurosci (2015) 22, 479-482. PubMed Europe PubMed DOI M

2014

Choi,D.H., Kim,J.H., Seo,J.H., Lee,J., Choi,W.S. and Kim,Y.S. Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress PLoS ONE (2014) 9, e115954-e115954. PubMed Europe PubMed DOI
Feng,Z., He,G., Chen,Z., Wu,Z. and Li,J. Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis BMC Musculoskelet Disord (2014) 15, 376-376. PubMed Europe PubMed DOI M
Kon,S., Nakayama,Y., Matsumoto,N., Ito,K., Kanayama,M., Kimura,C., Kouro,H., Ashitomi,D., Matsuda,T. and Uede,T. A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for alpha9beta1 integrin is involved in the anti-type II collagen antibody-induced arthritis PLoS ONE (2014) 9, e116210-e116210. PubMed Europe PubMed DOI
Lee,J.Y., Choi,H.Y., Ahn,H.J., Ju,B.G. and Yune,T.Y. Matrix metalloproteinase-3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury Am J Pathol (2014) 184, 2985-3000. PubMed Europe PubMed DOI I
Maize,K.M., Zhang,X. and Amin,E.A. Statistical analysis, optimization, and prioritization of virtual screening parameters for zinc enzymes including the anthrax toxin lethal factor Curr Top Med Chem (2014) 14, 2105-2114. PubMed Europe PubMed I
Wen,D., Du,X., Nie,S.P., Dong,J.Z. and Ma,C.S. Association Between Matrix Metalloproteinase Family Gene Polymorphisms and Ischemic Stroke: a Meta-analysis Mol Neurobiol (2014) 50, 979-985. PubMed Europe PubMed DOI M

2013

Belviso,B.D., Caliandro,R., Siliqi,D., Calderone,V., Arnesano,F. and Natile,G. Structure of matrix metalloproteinase-3 with a platinum-based inhibitor Chem Commun (Camb) (2013) 49, 5492-5494. PubMed Europe PubMed DOI S I
Chao,T., Frump,D., Lin,M., Caiozzo,V.J., Mozaffar,T., Steward,O. and Gupta,R. Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury Ann Neurol (2013) 73, 210-223. PubMed Europe PubMed DOI K
Furtwangler,T., Chan,S.C., Bahrenberg,G., Richards,P.J. and Gantenbein-Ritter,B. Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine Intervertebral disc organ culture model Spine (Phila Pa 1976) (2013) 38, E1377-E1387. PubMed Europe PubMed DOI
Stegemann,C., Didangelos,A., Barallobre-Barreiro,J., Langley,S.R., Mandal,K., Jahangiri,M. and Mayr,M. Proteomic identification of matrix metalloproteinase substrates in the human vasculature Circ Cardiovasc Genet (2013) 6, 106-117. PubMed Europe PubMed DOI P

2012

Ceruso,M., Howe,N. and Malthouse,J.P. Mechanism of the binding of Z-L-tryptophan and Z-L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions Biochim Biophys Acta (2012) 1824, 303-310. PubMed Europe PubMed DOI
Kim,S.K., Kang,S.W., Kim,D.H., Yun,D.H., Chung,J.H. and Ban,J.Y. Matrix metalloproteinase-3 gene polymorphisms are associated with ischemic stroke J Interferon Cytokine Res (2012) 32, 81-86. PubMed Europe PubMed DOI M
Nagase,H. Matrix metalloproteinase 3/stromelysin 1 [ISSN:978-0-12-407744-7] (2012) 3, 763-774. DOI
Shin,E.J., Kim,E.M., Lee,J.A., Rhim,H. and Hwang,O. Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinson's disease Neurochem Int (2012) 60, 249-256. PubMed Europe PubMed DOI
Shu,M., Zhang,Y.R., Tian,F.F., Yang,L. and Lin,Z.H. Molecular docking and 3D-QSAR research of biphenyl carboxylic acid MMP-3 inhibitors Jiegou Huaxue (2012) 31, 443-451. I
Van Hove,I., Verslegers,M., Buyens,T., Delorme,N., Lemmens,K., Stroobants,S., Gantois,I., D'Hooge,R. and Moons,L. An aberrant cerebellar development in mice lacking matrix metalloproteinase-3 Mol Neurobiol (2012) 45, 17-29. PubMed Europe PubMed DOI K
Van Hove,I., Lemmens,K., Van de Velde,S., Verslegers,M. and Moons,L. Matrix metalloproteinase-3 in the central nervous system: a look on the bright side J Neurochem (2012) 123, 203-216. PubMed Europe PubMed DOI
Wilfong,E.M., Du,Y. and Toone,E.J. An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1 Bioorg Med Chem Lett (2012) 22, 6521-6524. PubMed Europe PubMed DOI I

2011

Choi,S.S., Ji,A.R., Yu,S.W., Cho,B.H., Park,J.D., Park,J.H., Lee,H.S., Ryu,S.E., Kim,D.H., Kang,J.H. and Lee,S.T. Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors Bull Korean Chem Soc (2011) 32, 2032-2038. DOI I
Howe,N., Ceruso,M., Spink,E. and Malthouse,J.P. pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor Biochim Biophys Acta (2011) 1814, 1394-1403. PubMed Europe PubMed DOI I
Yamashita,C.M., Dolgonos,L., Zemans,R.L., Young,S.K., Robertson,J., Briones,N., Suzuki,T., Campbell,M.N., Gauldie,J., Radisky,D.C., Riches,D.W., Yu,G., Kaminski,N., McCulloch,C.A. and Downey,G.P. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis Am J Pathol (2011) 179, 1733-1745. PubMed Europe PubMed DOI

2010

Liang,X., Arunima,A., Zhao,Y., Bhaskaran,R., Shende,A., Byrne,T.S., Fleeks,J., Palmier,M.O. and Van Doren,S.R. Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3 Biophys J (2010) 99, 273-283. PubMed Europe PubMed DOI
Wilfong,E.M., Locklear,U. and Toone,E.J. A single step purification for autolytic zinc proteinases Bioorg Med Chem Lett (2010) 20, 280-282. PubMed Europe PubMed DOI E

2009

Juncker-Jensen,A., Romer,J., Pennington,C.J., Lund,L.R. and Almholt,K. Spontaneous metastasis in matrix metalloproteinase 3-deficient mice Mol Carcinog (2009) 48, 618-625. PubMed Europe PubMed DOI
Sahasrabudhe,P.V. and Stockman,B.J. Resonance assignments for stromelysin complexed with a beta-sulfonyl hydroxamate inhibitor Biomol NMR Assign (2009) 3, 183-186. PubMed Europe PubMed DOI S I

2008

Djuric,T., Zivkovic,M., Stankovic,A., Dincic,E., Raicevic,R. and Alavantic,D. Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia J Neurol Sci (2008) 267, 62-65. PubMed Europe PubMed DOI M

2007

Alcaraz,L.A., Banci,L., Bertini,I., Cantini,F., Donaire,A. and Gonnelli,L. Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors J Biol Inorg Chem (2007) 12, 1197-1206. PubMed Europe PubMed DOI S I
Kim,Y.S., Choi,D.H., Block,M.L., Lorenzl,S., Yang,L., Kim,Y.J., Sugama,S., Cho,B.P., Hwang,O., Browne,S.E., Kim,S.Y., Hong,J.S., Beal,M.F. and Joh,T.H. A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation FASEB J (2007) 21, 179-187. PubMed Europe PubMed DOI
Oceandy,D., Yusoff,R., Baudoin,F.M., Neyses,L. and Ray,S.G. Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients Eur J Heart Fail (2007) 9, 1010-1017. PubMed Europe PubMed DOI M
VanSaun,M., Humburg,B.C., Arnett,M.G., Pence,M. and Werle,M.J. Activation of matrix metalloproteinase-3 is altered at the frog neuromuscular junction following changes in synaptic activity Dev Neurobiol (2007) 67, 1488-1497. PubMed Europe PubMed DOI
Whitlock,G.A., Dack,K.N., Dickinson,R.P. and Lewis,M.L. A novel series of highly selective inhibitors of MMP-3 Bioorg Med Chem Lett (2007) 17, 6750-6753. PubMed Europe PubMed DOI I

2006

Amin,E.A. and Welsh,W.J. Highly predictive CoMFA and CoMSIA models for two series of stromelysin-1 (MMP-3) inhibitors elucidate S1' and S1-S2' binding modes J Chem Inf Model (2006) 46, 1775-1783. PubMed Europe PubMed DOI I
Chen,C.H., Lin,K.C., Yu,D.T., Yang,C., Huang,F., Chen,H.A., Liang,T.H., Liao,H.T., Tsai,C.Y., Wei,J.C. and Chou,C.T. Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity Rheumatology (Oxford) (2006) 45, 414-420. PubMed Europe PubMed DOI
[YEAR:27-3-2006]Kohno,T., Hochigai,H., Yamashita,E., Tsukihara,T. and Kanaoka,M. Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453 Biochem Biophys Res Commun (27-3-2006) 344, 315-322. PubMed Europe PubMed DOI S I
Si-Tayeb,K., Monvoisin,A., Mazzocco,C., Lepreux,S., Decossas,M., Cubel,G., Taras,D., Blanc,J.F., Robinson,D.R. and Rosenbaum,J. Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis Am J Pathol (2006) 169, 1390-1401. PubMed Europe PubMed DOI PMC EPMC I

2005

Beilby,J.P., Chapman,C.M., Palmer,L.J., McQuillan,B.M., Thompson,P.L. and Hung,J. Stromelysin-1 (MMP-3) gene 5A/6A promoter polymorphism is associated with blood pressure in a community population J Hypertens (2005) 23, 537-542. PubMed Europe PubMed
[YEAR:6-4-2005]Kim,Y.S., Kim,S.S., Cho,J.J., Choi,D.H., Hwang,O., Shin,D.H., Chun,H.S., Beal,M.F. and Joh,T.H. Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia J Neurosci (6-4-2005) 25, 3701-3711. PubMed Europe PubMed DOI I
Mora,B., Bonamico,M., Ferri,M., Megiorni,F., Osborn,J., Pizzuti,A. and Mazzilli,M.C. Association of the matrix metalloproteinase-3 (MMP-3) promoter polymorphism with celiac disease in male subjects Hum Immunol (2005) 66, 716-720. PubMed Europe PubMed DOI
[YEAR:4-4-2005]Sani,M., Candiani,G., Pecker,F., Malpezzi,L. and Zanda,M. Novel highly potent, structurally simple gamma-trifluoromethyl gamma-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3) Tetrahedron Lett (4-4-2005) 46, 2393-2396. I

2004

[YEAR:15-10-2004]Li,C.K., Pender,S.L., Pickard,K.M., Chance,V., Holloway,J.A., Huett,A., Goncalves,N.S., Mudgett,J.S., Dougan,G., Frankel,G. and Macdonald,T.T. Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice J Immunol (15-10-2004) 173, 5171-5179. PubMed Europe PubMed
Nagase,H. Stromelysin 1 [ISSN:0-12-079610-4] (2004) 2, 512-523. V

2003

Arumugam,S. and Van Doren,S.R. Global orientation of bound MMP-3 and N-TIMP-1 in solution via residual dipolar couplings Biochemistry (2003) 42, 7950-7958. PubMed Europe PubMed DOI S

2002

[YEAR:1-4-2002]Gearing,A.J., Thorpe,S.J., Miller,K., Mangan,M., Varley,P.G., Dudgeon,T., Ward,G., Turner,C. and Thorpe,R. Selective cleavage of human IgG by the matrix metalloproteinases, matrilysin and stromelysin Immunol Lett (1-4-2002) 81, 41-48. PubMed Europe PubMed DOI
[YEAR:12-12-2002]Yamada,Y., Izawa,H., Ichihara,S., Takatsu,F., Ishihara,H., Hirayama,H., Sone,T., Tanaka,M. and Yokota,M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes N Engl J Med (12-12-2002) 347, 1916-1923. PubMed Europe PubMed DOI M

2001

[YEAR:27-7-2001]Agnihotri,R., Crawford,H.C., Haro,H., Matrisian,L.M., Havrda,M.C. and Liaw,L. Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin) J Biol Chem (27-7-2001) 276, 28261-28267. PubMed Europe PubMed DOI
[YEAR:19-2-2001]Alexander,C.M., Selvarajan,S., Mudgett,J. and Werb,Z. Stromelysin-1 regulates adipogenesis during mammary gland involution J Cell Biol (19-2-2001) 152, 693-703. PubMed Europe PubMed DOI PMC EPMC
Arza,B., De Maeyer,M., Felez,J., Collen,D. and Lijnen,H.R. Critical role of glutamic acid 202 in the enzymatic activity of stromelysin-1 (MMP-3) Eur J Biochem (2001) 268, 826-831. PubMed Europe PubMed DOI
Dunten,P., Kammlott,U., Crowther,R., Levin,W., Foley,L.H., Wang,P. and Palermo,R. X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin Protein Sci (2001) 10, 923-926. PubMed Europe PubMed DOI PMC EPMC S I
Fray,M.J., Burslem,M.F. and Dickinson,R.P. Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality Bioorg Med Chem Lett (2001) 11, 567-570. PubMed Europe PubMed DOI I
[YEAR:11-6-2001]Lijnen,H.R., Van Hoef,B. and Collen,D. Inactivation of the serpin alpha(2)-antiplasmin by stromelysin-1 Biochim Biophys Acta (11-6-2001) 1547, 206-213. PubMed Europe PubMed DOI
Pikul,S., Dunham,K.M., Almstead,N.G., De,B., Natchus,M.G., Taiwo,Y.O., Williams,L.E., Hynd,B.A., Hsieh,L.C., Janusz,M.J., Gu,F. and Mieling,G.E. Heterocycle-based MMP inhibitors with P2' substituents Bioorg Med Chem Lett (2001) 11, 1009-1013. PubMed Europe PubMed DOI S I
Satsangi,J., Chapman,R.W., Haldar,N., Donaldson,P., Mitchell,S., Simmons,J., Norris,S., Marshall,S.E., Bell,J.I., Jewell,D.P. and Welsh,K.I. A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis Gastroenterology (2001) 121, 124-130. PubMed Europe PubMed M
Stix,B., Kahne,T., Sletten,K., Raynes,J., Roessner,A. and Rocken,C. Proteolysis of AA amyloid fibril proteins by matrix metalloproteinases-1, -2, and -3 Am J Pathol (2001) 159, 561-570. PubMed Europe PubMed DOI PMC EPMC
Warner,R.L., Beltran,L., Younkin,E.M., Lewis,C.S., Weiss,S.J., Varani,J. and Johnson,K.J. Role of stromelysin 1 and gelatinase B in experimental acute lung injury Am J Respir Cell Mol Biol (2001) 24, 537-544. PubMed Europe PubMed DOI K

2000

Cheng,M., De,B., Pikul,S., Almstead,N.G., Natchus,M.G., Anastasio,M.V., McPhail,S.J., Snider,C.E., Taiwo,Y.O., Chen,L., Dunaway,C.M., Gu,F., Dowty,M.E., Mieling,G.E., Janusz,M.J. and Wang-Weigand,S. Design and synthesis of piperazine-based matrix metalloproteinase inhibitors J Med Chem (2000) 43, 369-380. PubMed Europe PubMed DOI S I
Natchus,M.G., Bookland,R.G., De,B., Almstead,N.G., Pikul,S., Janusz,M.J., Heitmeyer,S.A., Hookfin,E.B., Hsieh,L.C., Dowty,M.E., Dietsch,C.R., Patel,V.S., Garver,S.M., Gu,F., Pokross,M.E., Mieling,G.E., Baker,T.R., Foltz,D.J., Peng,S.X., Bornes,D.M., Strojnowski,M.J. and Taiwo,Y.O. Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines J Med Chem (2000) 43, 4948-4963. PubMed Europe PubMed DOI S I
Steele,D.L., El-Kabbani,O., Dunten,P., Windsor,L.J., Kammlott,R.U., Crowther,R.L., Michoud,C., Engler,J.A. and Birktoft,J.J. Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1 Protein Eng (2000) 13, 397-405. PubMed Europe PubMed

1999

Almstead,N.G., Bradley,R.S., Pikul,S., De,B., Natchus,M.G., Taiwo,Y.O., Gu,F., Williams,L.E., Hynd,B.A., Janusz,M.J., Dunaway,C.M. and Mieling,G.E. Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors J Med Chem (1999) 42, 4547-4562. PubMed Europe PubMed DOI I
[YEAR:1-6-1999]Bullard,K.M., Mudgett,J., Scheuenstuhl,H., Hunt,T.K. and Banda,M.J. Stromelysin-1-deficient fibroblasts display impaired contraction in vitro J Surg Res (1-6-1999) 84, 31-34. PubMed Europe PubMed DOI K
Bullard,K.M., Lund,L., Mudgett,J.S., Mellin,T.N., Hunt,T.K., Murphy,B., Ronan,J., Werb,Z. and Banda,M.J. Impaired wound contraction in stromelysin-1-deficient mice Ann Surg (1999) 230, 260-265. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:29-10-1999]Chen,L., Rydel,T.J., Gu,F., Dunaway,C.M., Pikul,S., Dunham,K.M. and Barnett,B.L. Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes J Mol Biol (29-10-1999) 293, 545-557. PubMed Europe PubMed DOI S I
Cheng,M., De,B., Almstead,N.G., Pikul,S., Dowty,M.E., Dietsch,C.R., Dunaway,C.M., Gu,F., Hsieh,L.C., Janusz,M.J., Taiwo,Y.O., Natchus,M.G., Hudlicky,T. and Mandel,M. Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold J Med Chem (1999) 42, 5426-5436. PubMed Europe PubMed DOI S I
[YEAR:12-1-1999]Holman,C.M., Kan,C.C., Gehring,M.R. and Van Wart,H.E. Role of His-224 in the anomalous pH dependence of human stromelysin-1 Biochemistry (12-1-1999) 38, 677-681. PubMed Europe PubMed DOI
[YEAR:12-10-1999]Parker,M.H., Lunney,E.A., Ortwine,D.F., Pavlovsky,A.G., Humblet,C. and Brouillette,C.G. Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry Biochemistry (12-10-1999) 38, 13592-13601. PubMed Europe PubMed DOI I
Pavlovsky,A.G., Williams,M.G., Ye,Q.Z., Ortwine,D.F., Purchase,C.F., White,A.D., Dhanaraj,V., Roth,B.D., Johnson,L.L., Hupe,D., Humblet,C. and Blundell,T.L. X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity Protein Sci (1999) 8, 1455-1462. PubMed Europe PubMed DOI PMC EPMC S I
[YEAR:23-7-1999]Sternlicht,M.D., Lochter,A., Sympson,C.J., Huey,B., Rougier,J.P., Gray,J.W., Pinkel,D., Bissell,M.J. and Werb,Z. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis Cell (23-7-1999) 98, 137-146. PubMed Europe PubMed DOI
van Meurs,J., van Lent,P., Stoop,R., Holthuysen,A., Singer,I., Bayne,E., Mudgett,J., Poole,R., Billinghurst,C., Van der Kraan,P., Buma,P. and Van den Berg,W. Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity Arthritis Rheum (1999) 42, 2074-2084. PubMed Europe PubMed DOI
van Meurs,J., van Lent,P., Holthuysen,A., Lambrou,D., Bayne,E., Singer,I. and Van den Berg,W. Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction J Immunol (1999) 163, 5633-5639. PubMed Europe PubMed
Wang,M., Qin,X., Mudgett,J.S., Ferguson,T.A., Senior,R.M. and Welgus,H.G. Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response Proc Natl Acad Sci U S A (1999) 96, 6885-6889. PubMed Europe PubMed DOI PMC EPMC K

1998

del Mar Barbacid,M., Fernandez-Resa,P., Buesa,J.M., Marquez,G., Aracil,M., Quesadaand,A.R. and Mira,E. Expression and purification of human stromelysin 1 and 3 from baculovirus-infected insect cells Protein Expr Purif (1998) 13, 243-250. PubMed Europe PubMed DOI
Finzel,B.C., Baldwin,E.T., Bryant,G.L., Jr., Hess,G.F., Wilks,J.W., Trepod,C.M., Mott,J.E., Marshall,V.P., Petzold,G.L., Poorman,R.A., O'Sullivan,T.J., Schostarez,H.J. and Mitchell,M.A. Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity Protein Sci (1998) 7, 2118-2126. PubMed Europe PubMed DOI PMC EPMC S I
Kozaci,L.D., Brown,C.J., Adcocks,C., Galloway,A., Hollander,A.P. and Buttle,D.J. Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown J Clin Pathol Mol Pathol (1998) 51, 282-286. PubMed Europe PubMed
[YEAR:7-4-1998]Lijnen,H.R., Ugwu,F., Bini,A. and Collen,D. Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3) Biochemistry (7-4-1998) 37, 4699-4702. PubMed Europe PubMed DOI
Mudgett,J.S., Hutchinson,N.I., Chartrain,N.A., Forsyth,A.J., McDonnell,J., Singer,I.I., Bayne,E.K., Flanagan,J., Kawka,D., Shen,C.F., Stevens,K., Chen,H., Trumbauer,M. and Visco,D.M. Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction Arthritis Rheum (1998) 41, 110-121. PubMed Europe PubMed DOI K
Suzuki,K., Kan,C.C., Hung,W., Gehring,M.R., Brew,K. and Nagase,H. Expression of human pro-matrix metalloproteinase 3 that lacks the N-terminal 34 residues in Escherichia coli: autoactivation and interaction with tissue inhibitor of metalloproteinase 1 (TIMP-1) Biol Chem (1998) 379, 185-191. PubMed Europe PubMed
[YEAR:18-6-1998]Towle,C.A., Wright,M., Hecht,A.C., Kuong,S.J., Papanicolas,L.E., Totkovic,R., Mankin,H.J. and Treadwell,B.V. A matrix metalloproteinase proenzyme activator produced by articular cartilage Biochem Biophys Res Commun (18-6-1998) 247, 324-331. PubMed Europe PubMed DOI
[YEAR:19-5-1998]Ugwu,F., Van Hoef,B., Bini,A., Collen,D. and Lijnen,H.R. Proteolytic cleavage of urokinase-type plasminogen activator by stromelysin-1 (MMP-3) Biochemistry (19-5-1998) 37, 7231-7236. PubMed Europe PubMed DOI

1997

[YEAR:1-12-1997]Beekman,B., van El,B., Drijfhout,J.W., Ronday,H.K. and TeKoppele,J.M. Highly increased levels of active stromelysin in rheumatoid synovial fluid determined by a selective fluorogenic assay FEBS Lett (1-12-1997) 418, 305-309. PubMed Europe PubMed DOI A
Cherney,R.J., Decicco,C.P., Nelson,D.J., Wang,L., Meyer,D.T., Hardman,K.D., Copeland,R.A. and Arner,E.C. Potent carboxylate inhibitors of stromelysin containing P2' piperazic acids and P1' biaryl moeities Bioorg Med Chem Lett (1997) 7, 1757-1762. I
Esser,C.K., Bugianesi,R.L., Caldwell,C.G., Chapman,K.T., Durette,P.L., Girotra,N.N., Kopka,I.E., Lanza,T.J., Levorse,D.A., MacCross,M., Owens,K.A., Ponpipom,M.M., Simeone,J.P., Harrison,R.K., Niedzwiecki,L., Becker,J.W., Marcy,A.I., Axel,M.G., Christen,A.J., McDonnell,J., Moore,V.L., Olszewski,J.M., Saphos,C., Visco,D.M. and Hagmann,W.K. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides J Med Chem (1997) 40, 1026-1040. PubMed Europe PubMed DOI S I
[YEAR:4-9-1997]Gomis-Ruth,F.X., Maskos,K., Betz,M., Bergner,A., Huber,R., Suzuki,K., Yoshida,N., Nagase,H., Brew,K., Bourenkov,G.P., Bartunik,H. and Bode,W. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1 Nature (4-9-1997) 389, 77-81. PubMed Europe PubMed DOI S
Gonnella,N.C., Li,Y.C., Zhang,X. and Paris,C.G. Bioactive conformation of a potent stromelysin inhibitor determined by X-nucleus filtered and multidimensional NMR spectroscopy Bioorg Med Chem (1997) 5, 2193-2201. PubMed Europe PubMed DOI I
MacPherson,L.J., Bayburt,E.K., Capparelli,M.P., Carroll,B.J., Goldstein,R., Justice,M.R., Zhu,L., Hu,S., Melton,R.A., Fryer,L., Goldberg,R.L., Doughty,J.R., Spirito,S., Blancuzzi,V., Wilson,D., O'Byrne,E.M., Ganu,V. and Parker,D.T. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits J Med Chem (1997) 40, 2525-2532. PubMed Europe PubMed DOI I
Nagase,H., Suzuki,K., Cawston,T.E. and Brew,K. Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1) Biochem J (1997) 325, 163-167. PubMed Europe PubMed PMC EPMC
Quesada,A.R., Barbacid,M.M., Mira,E., Fernandez-Resa,P., Marquez,G. and Aracil,M. Evaluation of fluorometric and zymographic methods as activity assays for stromelysins and gelatinases Clin Exp Metastasis (1997) 15, 26-32. PubMed Europe PubMed DOI A
Rudolph-Owen,L.A., Hulboy,D.L., Wilson,C.L., Mudgett,J. and Matrisian,L.M. Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice Endocrinology (1997) 138, 4902-4911. PubMed Europe PubMed DOI K
Windsor,L.J., Steele,D.L., LeBlanc,S.B. and Taylor,K.B. Catalytic domain comparisons of human fibroblast-type collagenase, stromelysin-1, and matrilysin Biochim Biophys Acta (1997) 1334, 261-272. PubMed Europe PubMed DOI

1996

Benbow,U., Buttice,G., Nagase,H. and Kurkinen,M. Characterization of the 46-kDa intermediates of matrix metalloproteinase 3 (stromelysin 1) obtained by site-directed mutation of phenylalanine 83 J Biol Chem (1996) 271, 10715-10722. PubMed Europe PubMed DOI
Bini,A., Itoh,Y., Kudryk,B.J. and Nagase,H. Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405 peptide bond Biochemistry (1996) 35, 13056-13063. PubMed Europe PubMed DOI P
Dhanaraj,V., Ye,Q.Z., Johnson,L.L., Hupe,D.J., Ortwine,D.F., Dunbar,J.B., Jr., Rubin,J.R., Pavlovsky,A., Humblet,C. and Blundell,T.L. X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily Structure (1996) 4, 375-386. PubMed Europe PubMed S I
Welch,A.R., Holman,C.M., Huber,M., Brenner,M.C., Browner,M.F. and Van Wart,H.E. Understanding the P1' specificity of the matrix metalloproteinases: Effect of S1' pocket mutations in matrilysin and stromelysin- 1 Biochemistry (1996) 35, 10103-10109. PubMed Europe PubMed DOI

1995

Becker,J.W., Marcy,A.I., Rokosz,L.L., Axel,M.G., Burbaum,J.J., Fitzgerald,P.M., Cameron,P.M., Esser,C.K., Hagmann,W.K. and Hermes,J.D. Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme Protein Sci (1995) 4, 1966-1976. PubMed Europe PubMed DOI PMC EPMC S
Nagase,H. Human stromelysins 1 and 2 Methods Enzymol (1995) 248, 449-470. PubMed Europe PubMed DOI V

1994

[YEAR:29-4-1994]Baragi,V.M., Fliszar,C.J., Conroy,M.C., Ye,Q.Z., Shipley,J.M. and Welgus,H.G. Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin J Biol Chem (29-4-1994) 269, 12692-12697. PubMed Europe PubMed
[YEAR:14-10-1994]Fowlkes,J.L., Enghild,J.J., Suzuki,K. and Nagase,H. Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures J Biol Chem (14-10-1994) 269, 25742-25746. PubMed Europe PubMed P
[YEAR:19-8-1994]Nagase,H., Fields,C.G. and Fields,G.B. Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3) J Biol Chem (19-8-1994) 269, 20952-20957. PubMed Europe PubMed
Nguyen,Q., Willenbrock,F., Cockett,M.I., O'Shea,M., Docherty,A.J. and Murphy,G. Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A Biochemistry (1994) 33, 2089-2095. PubMed Europe PubMed
Soler,D., Nomizu,T., Brown,W.E., Chen,M., Ye,Q.Z., Van Wart,H.E. and Auld,D.S. Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain Biochem Biophys Res Commun (1994) 201, 917-923. PubMed Europe PubMed DOI
[YEAR:2-3-1994]Zhang,Z., Winyard,P.G., Chidwick,K., Murphy,G., Wardell,M., Carrell,R.W. and Blake,D.R. Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin Biochim Biophys Acta (2-3-1994) 1199, 224-228. PubMed Europe PubMed DOI

1993

[YEAR:5-10-1993]Chen,L.C., Noelken,M.E. and Nagase,H. Disruption of the cysteine-75 and zinc ion coordination is not sufficient to activate the precursor of human matrix metalloproteinase 3 (stromelysin 1) Biochemistry (5-10-1993) 32, 10289-10295. PubMed Europe PubMed DOI
Formstone,C.J., Byrd,P.J., Ambrose,H.J., Riley,J.H., Hernandez,D., McConville,C.M. and Taylor,A.M. The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23 Genomics (1993) 16, 289-291. PubMed Europe PubMed DOI
[YEAR:15-8-1993]Windsor,L.J., Grenett,H., Birkedal-Hansen,B., Bodden,M.K., Engler,J.A. and Birkedal-Hansen,H. Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters J Biol Chem (15-8-1993) 268, 17341-17347. PubMed Europe PubMed

1992

Hammani,K., Henriet,P. and Eeckhout,Y. Cloning and sequencing of a cDNA encoding mouse stromelysin 1 Gene (1992) 120, 321-322. PubMed Europe PubMed DOI
Ogata,Y., Enghild,J.J. and Nagase,H. Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9 J Biol Chem (1992) 267, 3581-3584. PubMed Europe PubMed
Ye,Q.Z., Johnson,L.L., Hupe,D.J. and Baragi,V. Purification and characterization of the human stromelysin catalytic domain expressed in Escherichia coli Biochemistry (1992) 31, 11231-11235. PubMed Europe PubMed DOI E

1991

Fosang,A.J., Neame,P.J., Hardingham,T.E., Murphy,G. and Hamilton,J.A. Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins J Biol Chem (1991) 266, 15579-15582. PubMed Europe PubMed
Mast,A.E., Enghild,J.J., Nagase,H., Suzuki,K., Pizzo,S.V. and Salvesen,G. Kinetics and physiologic relevance of the inactivation of alpha1- proteinase inhibitor, alpha1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin) J Biol Chem (1991) 266, 15810-15816. PubMed Europe PubMed
Woessner,J.F., Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling FASEB J (1991) 5, 2145-2154. PubMed Europe PubMed

1990

Docherty,A.J. and Murphy,G. The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins Ann Rheum Dis (1990) 49 Suppl 1, 469-479. PubMed Europe PubMed
Emonard,H. and Grimaud,J.A. Matrix metalloproteinases. A review Cell Mol Biol (1990) 36, 131-153. PubMed Europe PubMed
[YEAR:19-6-1990]Nagase,H., Enghild,J.J., Suzuki,K. and Salvesen,G. Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate Biochemistry (19-6-1990) 29, 5783-5789. PubMed Europe PubMed DOI
Suzuki,K., Enghild,J.J., Morodomi,T., Salvesen,G. and Nagase,H. Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin) Biochemistry (1990) 29, 10261-10270. PubMed Europe PubMed

1989

Enghild,J.J., Salvesen,G., Brew,K. and Nagase,H. Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites J Biol Chem (1989) 264, 8779-8785. PubMed Europe PubMed
Nicholson,R., Murphy,G. and Breathnach,R. Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases Biochemistry (1989) 28, 5195-5203. PubMed Europe PubMed
Teahan,J., Harrison,R., Izquierdo,M. and Stein,R.L. Substrate specificity of human fibroblast stromelysin. Hydrolysis of substance P and its analogues Biochemistry (1989) 28, 8497-8501. PubMed Europe PubMed P

1987

Wilhelm,S.M., Collier,I.E., Kronberger,A., Eisen,A.Z., Marmer,B.L., Grant,G.A., Bauer,E.A. and Goldberg,G.I. Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells Proc Natl Acad Sci U S A (1987) 84, 6725-6729. PubMed Europe PubMed PMC EPMC

1986

Matrisian,L.M., Bowden,G.T., Krieg,P., Furstenberger,G., Briand,J.P., Leroy,P. and Breathnach,R. The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors Proc Natl Acad Sci U S A (1986) 83, 9413-9417. PubMed Europe PubMed PMC EPMC
Murphy,G., Hembry,R.M. and Reynolds,J.J. Characterization of a specific antiserum to rabbit stromelysin and demonstration of the synthesis of collagenase and stromelysin by stimulated rabbit articular chondrocytes Coll Relat Res (1986) 6, 351-363. PubMed Europe PubMed
Okada,Y., Nagase,H. and Harris,E.D., Jr. A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization J Biol Chem (1986) 261, 14245-14255. PubMed Europe PubMed

1985

Chin,J.R., Murphy,G. and Werb,Z. Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates J Biol Chem (1985) 260, 12367-12376. PubMed Europe PubMed