Structure for peptidase M10.005: matrix metallopeptidase-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1G49 Homo sapiens 1.90 Å catalytic domain; complex with carboxylic acid based inhibitor (1N)-4-N-butoxyphenylsulfonyl-(2R)-N-hydroxycarboxamido-(4S)-methanesulfonylamino-pyrrolidine
The catalytic and structural zinc ions are shown as light grey CPK spheres. The structural calcium ions are shown as yellow CPK spheres. The zinc ligands are shown in ball-and-stick representation: His218, His222 and His222 in purple. The catalytic Glu219 is shown in blue.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Equus caballus
theoretical model 0.00 Å 1L9I 1L9I 1L9I 1L9I 1L9I 1L9I
Homo sapiens
complex with N-[[2-methyl-4-hydroxycarbamoyl]but-4-yl-N]-benzyl-P-[phenyl]-P-[methyl]phosphinamide 2.30 Å 1B3D 1B3D 1B3D 1B3D 1B3D 1B3D Chen et al., 1999
catalytic domain; complex with diphenylpiperidine sulfonamide inhibitor 2.00 Å 1B8Y 1B8Y 1B8Y 1B8Y 1B8Y 1B8Y Pavlovsky et al., 1999
complex with N1-hydroxy-2-(3-hydroxy-propyl)-3-isobutyl-N4-[1-(2-methoxy-ethyl)-2-oxo-azepan-3-yl]-succinamide 2.50 Å 1BIW 1BIW 1BIW 1BIW 1BIW 1BIW Natchus et al., 1998
NMR structure; complex with N-HYDROXY-2(R)- [4-METHOXYSULFONYL](3-PICOLYL)AMINO]-3-methylbutaneamide hydrochloride monohydrate inhibitor 0.00 Å 1BM6 1BM6 1BM6 1BM6 1BM6 1BM6 Li et al., 1998
complex with interstitial collagenase and PG-117025 inhibitor 2.30 Å 1BQO 1BQO 1BQO 1BQO 1BQO 1BQO Pikul et al., 1998
catalytic domain; complex with RO-26-2812 synthetic inhibitor 1.83 Å 1C3I 1C3I 1C3I 1C3I 1C3I 1C3I Steele et al., 2000
catalytic domain; complex with RO-26-2812 2.60 Å 1C8T 1C8T 1C8T 1C8T 1C8T 1C8T Steele et al., 2000
catalytic domain; complex with diphenyl piperidine sulfonamide 1.80 Å 1CAQ 1CAQ 1CAQ 1CAQ 1CAQ 1CAQ Pavlovsky et al., 1999
catalytic domain; complex with 3-(1H-indol-3-yl)-2-[4-(4-phenyl-piperidin-1-yl)-benzenesulfonylamino]-propionic acid inhibitor 1.64 Å 1CIZ 1CIZ 1CIZ 1CIZ 1CIZ 1CIZ Pavlovsky et al., 1999
catalytic domain 2.00 Å 1CQR 1CQR 1CQR 1CQR 1CQR 1CQR Chen et al., 1999
complex with N-hydroxy-4-[(4-methoxylphenyl)sulfonyl]-2,2-dimethyl-hexahydro-1,4-thiazepine-3(S)-carboxamide 2.60 Å 1D5J 1D5J 1D5J 1D5J 1D5J 1D5J Almstead et al., 1999
complex with N-hydroxy 1N(4-methoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-2R-carboxamide inhibitor 2.00 Å 1D7X 1D7X 1D7X 1D7X 1D7X 1D7X Cheng et al., 1999
complex with N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-benzyloxycarbonyl-piperazine-2-carboxamide inhibitor 2.40 Å 1D8F 1D8F 1D8F 1D8F 1D8F 1D8F Cheng et al., 2000
catalytic domain; complex with 1-benzyl-3-(4-methoxy-benzenesulfonyl)-6-oxo-hexahydro-pyrimidine-4-carboxamide inhibitor 2.44 Å 1D8M 1D8M 1D8M 1D8M 1D8M 1D8M Pikul et al., 2001
catalytic domain; complex with heterocycle-based inhibitor 2.45 Å 1G05 1G05 1G05 1G05 1G05 1G05 Pikul et al., 2001
catalytic domain; complex with carboxylic acid based inhibitor (1N)-4-N-butoxyphenylsulfonyl-(2R)-N-hydroxycarboxamido-(4S)-methanesulfonylamino-pyrrolidine 1.90 Å 1G49 1G49 1G49 1G49 1G49 1G49 Natchus et al., 2000
catalytic domain; complex with HQQ inhibitor 2.00 Å 1G4K 1G4K 1G4K 1G4K 1G4K 1G4K Dunten et al., 2001
catalytic domain; complex with N-carboxy-alkyl inhibitor L-764,004 1.70 Å 1HFS 1HFS 1HFS 1HFS 1HFS 1HFS Esser et al., 1997
catalytic domain; complex with a carboxylic acid based inhibitor 1.50 Å 1HY7 1HY7 1HY7 1HY7 1HY7 1HY7 Natchus et al., 2001
theoretical model 0.00 Å 1M1W 1M1W 1M1W 1M1W 1M1W 1M1W
NMR structure; complex with human stromelysin catalytic domain 0.00 Å 1OO9 1OO9 1OO9 1OO9 1OO9 1OO9 Arumugam & Van, 2003
catalytic domain 2.00 Å 1QIA 1QIA 1QIA 1QIA 1QIA 1QIA Pavlovsky et al., 1999
catalytic domain; complex with diphenylpiperidine inhibitor 2.00 Å 1QIC 1QIC 1QIC 1QIC 1QIC 1QIC Pavlovsky et al., 1999
C-truncated proenzyme 1.90 Å 1SLM 1SLM 1SLM 1SLM 1SLM 1SLM Becker et al., 1995
catalytic domain; complex with the N-carboxyl-alkyl inhibitor L-702,842 2.27 Å 1SLN 1SLN 1SLN 1SLN 1SLN 1SLN Becker et al., 1995
catalytic domain; complex with TIMP-1 2.80 Å 1UEA 1UEA 1UEA 1UEA 1UEA 1UEA Gomis-Ruth et al., 1997
NMR structure of catalytic domain; complex with (R,S)-N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-Leu-Phe-NH2 inhibitor 0.00 Å 1UMS 1UMS 1UMS 1UMS 1UMS 1UMS Van et al., 1995
NMR structure; catalytic domain; complex with hydrophobic inhibitor 0.00 Å 1UMT 1UMT 1UMT 1UMT 1UMT 1UMT Van et al., 1995
catalytic domain; complex with thiadiazole inhibitor PNU-142372 1.80 Å 1USN 1USN 1USN 1USN 1USN 1USN Finzel et al., 1998
stromelysin-1 (mmp-3) complexed to a hydroxamic acid inhibitor 2.02 Å 2D1O 2D1O 2D1O 2D1O 2D1O 2D1O Kohno et al., 2006
mature  peptidase 0.00 Å 2JNP 2JNP 2JNP 2JNP 2JNP 2JNP Alcaraz et al., 2007
mature  peptidase 0.00 Å 2JT5 2JT5 2JT5 2JT5 2JT5 2JT5 Alcaraz et al., 2007
mature  peptidase 0.00 Å 2JT6 2JT6 2JT6 2JT6 2JT6 2JT6 Alcaraz et al., 2007
NMR structure of catalytic domain; complex with N-(R-carboxy-ethyl)-alpha-(S)-(2-phenyl ether) Gly-L-Arg-N-phenylamide 0.00 Å 2SRT 2SRT 2SRT 2SRT 2SRT 2SRT Gooley et al., 1994
catalytic domain; complex with thiadiazole inhibitor PNU-141803 2.20 Å 2USN 2USN 2USN 2USN 2USN 2USN Finzel et al., 1998
mature  peptidase 2.36 Å 3OHL 3OHL 3OHL 3OHL 3OHL 3OHL
mature  peptidase 2.50 Å 3OHO 3OHO 3OHO 3OHO 3OHO 3OHO
NMR structure of catalytic domain; complex with thiadiazole inhibitor IPNU-107859 0.00 Å 3USN 3USN 3USN 3USN 3USN 3USN Stockman et al., 1998
mature  peptidase 1.96 Å 4DPE 4DPE 4DPE 4DPE 4DPE 4DPE Belviso et al., 2013
mature  peptidase 1.88 Å 4G9L 4G9L 4G9L 4G9L 4G9L 4G9L Belviso et al., 2013
mature  peptidase 1.96 Å 4JA1 4JA1 4JA1 4JA1 4JA1 4JA1 Belviso et al., 2013
catalytic domain; complex with tissue inhibitor of metalloproteinase-1 (timp-1) mutant Leu34Gly 2.37 Å 6MAV 6MAV 6MAV 6MAV 6MAV 6MAV
catalytic domain; complex with tissue inhibitor of metalloproteinases-1 (timp-1) mutant (Leu34Gly/Leu133Pro/Leu151Cys/Gly154Ala) 2.67 Å 6N9D 6N9D 6N9D 6N9D 6N9D 6N9D