$VAR1 = undef;

Summary for peptidase M10.002: matrix metallopeptidase-8

Names
MEROPS Name	matrix metallopeptidase-8
Other names	collagenase 2, matrix metalloproteinase 8, MMP-8, neutrophil collagenase

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.002
Holotype	matrix metallopeptidase-8 (Homo sapiens), Uniprot accession P22894 (peptidase unit: 97-275), MERNUM MER0001084
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00155
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.34
Enzymology	BRENDA database
Proteolytic events	CutDB database (72 cleavages)
Activity status	human: active (Tschesche et al., 2004) mouse: active (Balbin et al., 1998)
Physiology	Role in turnover of extracellular matrix proteins.
Knockout	Mice deficient in collagenase 2 developed normally, but males showed a high incidence of skin tumors (Balbin et al., 2003).
Pharmaceutical relevance	Drug target for prevention of pathological tissue damage.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP8
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	g/pas/-/gl/-/g/- (based on 123 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	36	2	3	35	1	2	38	7
Pro	4	45	10	10	0	2	3	12
Ala	6	21	12	14	9	10	14	13
Val	6	6	3	3	12	8	5	4
Leu	13	10	11	4	38	5	3	13
Ile	3	2	1	0	13	5	4	5
Met	0	1	3	0	1	5	0	1
Phe	5	5	3	9	11	5	0	2
Tyr	1	0	2	4	3	1	1	0
Trp	0	0	1	0	0	4	1	0
Ser	6	16	16	6	4	12	13	11
Thr	7	0	1	3	2	5	8	8
Cys	0	0	0	0	0	0	2	0
Asn	3	2	4	9	3	4	1	5
Gln	4	3	19	3	6	12	8	11
Asp	4	1	2	4	2	2	2	5
Glu	5	3	6	7	1	4	4	5
Lys	9	4	12	9	7	9	4	2
Arg	4	0	11	1	6	21	3	9
His	2	2	3	2	2	3	3	0