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Literature for peptidase M10.002: matrix metallopeptidase-8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Deng,X., You,Y., Lv,S. and Liu,Y.<br>MMP8-mediated vascular remodeling in pulmonary hypertension<br>Biochim Biophys Acta Mol Basis Dis (2025) 1871, 167582-167582. PubMed  Europe PubMed DOI
  2. Zhang,D., Xu,C., Liang,M., Shao,W., Wang,P., Yang,Y. and Guo,K.<br>Diagnostic Accuracy of Matrix Metalloproteinase-8 for Detecting Periodontal Disease: A Meta-Analysis<br>Oral Dis (2025) PubMed  Europe PubMed DOI
    3. 2024
  3. Cathomas,F., Lin,H.Y., Chan,K.L., Li,L., Parise,L.F., Alvarez,J., Durand-de Cuttoli,R., Aubry,A.V., Muhareb,S., Desland,F., Shimo,Y., Ramakrishnan,A., Estill,M., Ferrer-Perez,C., Parise,E.M., Wilk,C.M., Kaster,M.P., Wang,J., Sowa,A., Janssen,W.G., Costi,S., Rahman,A., Fernandez,N., Campbell,M., Swirski,F.K., Nestler,E.J., Shen,L., Merad,M., Murrough,J.W. and Russo,S.J.<br>Circulating myeloid-derived MMP8 in stress susceptibility and depression<br>Nature (2024) 626, 1108-1115. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J.<br>Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Ranta,J., Havulinna,A.S., Tervahartiala,T., Niemi,K., Aarabi,G., Vihervaara,T., Salomaa,V., Sorsa,T., Pussinen,P.J. and Salminen,A.<br>Serum MMP-8 and TIMP-1 concentrations in a population-based cohort: effects of age, gender, and health status<br>Front Dent Med (2024) 5, 1315596-1315596. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Yates,D.<br>MMP8 and stress susceptibility<br>Nat Rev Neurosci (2024) 25, 209-209. PubMed  Europe PubMed DOI
    7. 2023
  7. Atanasova,T., Stankova,T., Bivolarska,A. and Vlaykova,T.<br>Matrix Metalloproteinases in Oral Health-Special Attention on MMP-8<br>Biomedicines (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Port,H., Hausgaard,C.M., He,Y., Maksymowych,W.P., Wichuk,S., Sinkeviciute,D., Bay-Jensen,A.C. and Holm Nielsen,S.<br>A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis<br>Sci Rep (2023) 13, 21717-21717. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2022
  9. Fang,X., Duan,S.F., Hu,Z.Y., Wang,J.J., Qiu,L., Wang,F. and Chen,X.L.<br>Inhibition of Matrix Metalloproteinase-8 Protects Against Sepsis Serum Mediated Leukocyte Adhesion<br>Front Med (Lausanne) (2022) 9, 814890-814890. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Gu,H., Peng,J., Wang,M., Guo,Z., Huang,H. and Yan,L.<br>MicroRNA-320-3p promotes the progression of acute pancreatitis by blocking DNMT3a-mediated MMP8 methylation in a targeted manner<br>Mol Immunol (2022) 151, 84-94. PubMed  Europe PubMed DOI
  11. Lahteenmaki,H., Tervahartiala,T., Raisanen,I.T., Parnanen,P., Mauramo,M., Gupta,S., Sampson,V., Rathnayake,N., Heikkinen,A.M., Alassiri,S., Gieselmann,D.R., Frankenberger,R. and Sorsa,T.<br>Active MMP-8 point-of-care (PoC)/chairside enzyme-test as an adjunctive tool for early and real-time diagnosis of peri-implantitis<br>Clin Exp Dent Res (2022) 8, 485-496. PubMed  Europe PubMed DOI  L
  12. Lee,M.R., Chen,Y.L., Wu,C.W., Chen,L.C., Chang,L.Y., Chen,J.Y., Huang,Y.T., Wang,J.Y., Shih,J.Y. and Yu,C.J.<br>Toll-like receptor and matrix metalloproteinase single-nucleotide polymorphisms, haplotypes, and polygenic risk score differentiated between tuberculosis disease and infection<br>Int J Infect Dis (2022) 125, 61-66. PubMed  Europe PubMed DOI  M
  13. Samulenas,G., Insodaite,R., Kunceviciene,E., Poceviciute,R., Masionyte,L., Zitkeviciute,U., Pilipaityte,L. and Smalinskiene,A.<br>The Role of Functional Polymorphisms in the Extracellular Matrix Modulation-Related Genes on Dupuytren's Contracture<br>Genes (Basel) (2022) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  14. Umeizudike,K.A., Lahteenmaki,H., Raisanen,I.T., Taylor,J.J., Preshaw,P.M., Bissett,S.M., Tervahartiala,T., Nwhator,O., Parnanen,P. and Sorsa,T.<br>Ability of matrix metalloproteinase-8 biosensor, IFMA, and ELISA immunoassays to differentiate between periodontal health, gingivitis, and periodontitis<br>J Periodontal Res (2022) 57, 558-567. PubMed  Europe PubMed DOI
  15. Zhang,C., Niu,K., Ren,M., Zhou,X., Yang,Z., Yang,M., Wang,X., Luo,J., Shao,Y., Zhang,C., Chen,D., Gao,S., Ge,S., Wu,Q. and Xiao,Q.<br>Targeted Inhibition of Matrix Metalloproteinase-8 Prevents Aortic Dissection in a Murine Model<br>Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2021
  16. Bassiouni,W., Ali,M.A.M. and Schulz,R.<br>Multifunctional intracellular matrix metalloproteinases: implications in disease<br>FEBS J (2021) 288, 7162-7182. PubMed  Europe PubMed DOI  V
  17. Guti,S., Baidya,S.K., Banerjee,S., Adhikari,N. and Jha,T.<br>A robust classification-dependent multi-molecular modelling study on some biphenyl sulphonamide based MMP-8 inhibitors<br>SAR QSAR Environ Res (2021) 32, 835-861. PubMed  Europe PubMed DOI  I
  18. Hernandez,M., Baeza,M., Raisanen,I.T., Contreras,J., Tervahartiala,T., Chaparro,A., Sorsa,T. and Hernandez-Rios,P.<br>Active MMP-8 Quantitative Test as an Adjunctive Tool for Early Diagnosis of Periodontitis<br>Diagnostics (Basel) (2021) 11, 1503-1503. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Petain,S., Kasnak,G., Firatli,E., Tervahartiala,T., Gursoy,U.K. and Sorsa,T.<br>Periodontitis and peri-implantitis tissue levels of Treponema denticola-CTLP and its MMP-8 activating ability<br>Acta Histochem (2021) 123, 151767-151767. PubMed  Europe PubMed DOI
  20. Wang,X., Zhang,D., Fucci,Q.A., Dollery,C.M. and Owen,C.A.<br>Surface-bound matrix metalloproteinase-8 on macrophages: Contributions to macrophage pericellular proteolysis and migration through tissue barriers<br>Physiol Rep (2021) 9, e14778-e14778. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2020
  21. Morla,S. and Desai,U.R.<br>Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8<br>Biomolecules (2020) 10, 1166-1166. PubMed  Europe PubMed DOI  PMC  EPMC  I
  22. Pan,S., Zhang,Z., Li,C. and Yang,D.<br>Interleukin-25 regulates matrix metalloproteinase-2 and -9 expression in periodontal fibroblast cells through ERK and P38MAPK pathways<br>Cell Biol Int (2020) PubMed  Europe PubMed DOI
  23. Roy,H.S., Dubey,G., Sharma,V.K., Bharatam,P.V. and Ghosh,D.<br>Molecular docking and molecular dynamics to identify collagenase inhibitors as lead compounds to address osteoarthritis<br>J Biomol Struct Dyn (2020) , 1-13. PubMed  Europe PubMed DOI  I
  24. Wu,W., Peng,S., Shi,Y., Li,L., Song,Z. and Lin,S.<br>NPY promotes macrophage migration by upregulating matrix metalloproteinase-8 expression<br>J Cell Physiol (2020) 236, 1903-1912. PubMed  Europe PubMed DOI
    25. 2019
  25. Abu Bakar,A.R., Ripen,A.M., Merican,A.F. and Mohamad,S.B.<br>Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9<br>Nat Prod Res (2019) 33, 1765-1768. PubMed  Europe PubMed DOI  I
    26. 2018
  26. Kumar,H., Jo,M.J., Choi,H., Muttigi,M.S., Shon,S., Kim,B.J., Lee,S.H. and Han,I.B.<br>Matrix metalloproteinase-8 inhibition prevents disruption of blood-spinal cord barrier and attenuates inflammation in rat model of spinal cord injury<br>Mol Neurobiol (2018) 55, 2577-2590. PubMed  Europe PubMed DOI  I
    27. 2017
  27. Inanc,S., Keles,D. and Oktay,G.<br>An improved collagen zymography approach for evaluating the collagenases MMP-1, MMP-8, and MMP-13<br>Biotechniques (2017) 63, 174-180. PubMed  Europe PubMed DOI  L
    28. 2016
  28. Demeestere,D., Dejonckheere,E., Steeland,S., Hulpiau,P., Haustraete,J., Devoogdt,N., Wichert,R., Becker-Pauly,C., Van Wonterghem,E., Dewaele,S., Van Imschoot,G., Aerts,J., Arckens,L., Saeys,Y., Libert,C. and Vandenbroucke,R.E.<br>Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8<br>Mol Ther (2016) 24, 890-902. PubMed  Europe PubMed DOI
  29. Han,J.E., Lee,E.J., Moon,E., Ryu,J.H., Choi,J.W. and Kim,H.S.<br>Matrix metalloproteinase-8 is a novel pathogenetic factor in focal cerebral ischemia<br>Mol Neurobiol (2016) 53, 231-239. PubMed  Europe PubMed DOI  K
  30. Tucker,J.K., McNiff,M.L., Ulapane,S.B., Spencer,P., Laurence,J.S. and Berrie,C.L.<br>Mechanistic investigations of matrix metalloproteinase-8 inhibition by metal abstraction peptide<br>Biointerphases (2016) 11, 021006-021006. PubMed  Europe PubMed DOI  I
    31. 2015
  31. Salminen,A., Astrom,P., Metso,J., Soliymani,R., Salo,T., Jauhiainen,M., Pussinen,P.J. and Sorsa,T.<br>Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux capacity<br>FASEB J (2015) 29, 1435-1445. PubMed  Europe PubMed DOI
  32. Wen,G., Zhang,C., Chen,Q., Luong,l.A., Mustafa,A., Ye,S. and Xiao,Q.<br>A novel role of matrix metalloproteinase-8 in macrophage differentiation and polarization<br>J Biol Chem (2015) 290, 19158-19172. PubMed  Europe PubMed DOI
    33. 2014
  33. Arnett,E., Vadia,S., Nackerman,C.C., Oghumu,S., Satoskar,A.R., McLeish,K.R., Uriarte,S.M. and Seveau,S.<br>The pore-forming toxin listeriolysin O is degraded by neutrophil metalloproteinase-8 and fails to mediate Listeria monocytogenes intracellular survival in neutrophils<br>J Immunol (2014) 192, 234-244. PubMed  Europe PubMed DOI
  34. Ding,D., Lichtenwalter,K., Pi,H., Mobashery,S. and Chang,M.<br>Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)<br>MedChemComm (2014) 5, 1381-1383. DOI  I
  35. Kalva,S., Vinod,D. and Saleena,L.M.<br>Combined structure- and ligand-based pharmacophore modeling and molecular dynamics simulation studies to identify selective inhibitors of MMP-8<br>J Mol Model (2014) 20, 2191-2191. PubMed  Europe PubMed DOI  I
  36. Lee,E.J., Han,J.E., Woo,M.S., Shin,J.A., Park,E.M., Kang,J.L., Moon,P.G., Baek,M.C., Son,W.S., Ko,Y.T., Choi,J.W. and Kim,H.S.<br>Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-alpha activation<br>J Immunol (2014) 193, 2384-2393. PubMed  Europe PubMed DOI
    37. 2013
  37. Chakrabarti,B., Bairagya,H.R., Mishra,D.K., Chatterjee,P.K. and Mukhopadhyay,B.P.<br>Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human matrix metalloproteinase-8 enzyme: A study by MD-simulation methods<br>Bioinformation (2013) 9, 126-133. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Hugenberg,V., Riemann,B., Hermann,S., Schober,O., Schafers,M., Szardenings,K., Lebedev,A., Gangadharmath,U., Kolb,H., Walsh,J., Zhang,W., Kopka,K. and Wagner,S.<br>Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (Radio)synthesis, in vitro and first in vivo evaluation<br>J Med Chem (2013) 56, 6858-6870. PubMed  Europe PubMed DOI  I
  39. Lu,K.G. and Stultz,C.M.<br>Insight into the degradation of type-I collagen fibrils by MMP-8<br>J Mol Biol (2013) 425, 1815-1825. PubMed  Europe PubMed DOI
  40. Mori,M., Massaro,A., Calderone,V., Fragai,M., Luchinat,C. and Mordini,A.<br>Discovery of a new class of potent MMP inhibitors by structure-based optimization of the arylsulfonamide scaffold<br>ACS Med Chem Lett (2013) 4, 565-569. PubMed  Europe PubMed DOI  I
    41. 2012
  41. Solan,P.D., Dunsmore,K.E., Denenberg,A.G., Odoms,K., Zingarelli,B. and Wong,H.R.<br>A novel role for matrix metalloproteinase-8 in sepsis<br>Crit Care Med (2012) 40, 379-387. PubMed  Europe PubMed DOI  K
  42. Tschesche,H. and Wenzel,H.<br>Neutrophil collagenase<br>[ISSN:978-0-12-407744-7] (2012) 3, 725-734. DOI
    43. 2011
  43. Robichaud,T.K., Steffensen,B. and Fields,G.B.<br>Exosite interactions impact matrix metalloproteinase collagen specificities<br>J Biol Chem (2011) 286, 37535-37542. PubMed  Europe PubMed DOI  P
    44. 2010
  44. Devel,L., Czarny,B., Beau,F., Georgiadis,D., Stura,E. and Dive,V.<br>Third generation of matrix metalloprotease inhibitors: gain in selectivity by targeting the depth of the S1' cavity<br>Biochimie (2010) 92, 1501-1508. PubMed  Europe PubMed DOI  I
  45. Garcia,S., Forteza,J., Lopez-Otin,C., Gomez-Reino,J.J., Gonzalez,A. and Conde,C.<br>Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model<br>Arthritis Res Ther (2010) 12, R224-R224. PubMed  Europe PubMed DOI  K
    46. 2009
  46. Lopez-Otin,C., Palavalli,L.H. and Samuels,Y.<br>Protective roles of matrix metalloproteinases: from mouse models to human cancer<br>Cell Cycle (2009) 8, 3657-3662. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Palavalli,L.H., Prickett,T.D., Wunderlich,J.R., Wei,X., Burrell,A.S., Porter-Gill,P., Davis,S., Wang,C., Cronin,J.C., Agrawal,N.S., Lin,J.C., Westbroek,W., Hoogstraten-Miller,S., Molinolo,A.A., Fetsch,P., Filie,A.C., O'Connell,M.P., Banister,C.E., Howard,J.D., Buckhaults,P., Weeraratna,A.T., Brody,L.C., Rosenberg,S.A. and Samuels,Y.<br>Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma<br>Nat Genet (2009) 41, 518-520. PubMed  Europe PubMed DOI  PMC  EPMC  M
  48. Pochetti,G., Montanari,R., Gege,C., Chevrier,C., Taveras,A.G. and Mazza,F.<br>Extra binding region induced by non-zinc chelating inhibitors into the S1' subsite of matrix metalloproteinase 8 (MMP-8)<br>J Med Chem (2009) 52, 1040-1049. PubMed  Europe PubMed DOI  S  I
    49. 2007
  49. [YEAR:25-1-2007]Aschi,M., Besker,N., Re,N., Pochetti,G., Coletti,C., Gallina,C. and Mazza,F.<br>Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations<br>J Med Chem (25-1-2007) 50, 211-218. PubMed  Europe PubMed DOI  I
  50. Cheng,J., Sauthoff,H., Huang,Y., Kutler,D.I., Bajwa,S., Rom,W.N. and Hay,J.G.<br>Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus<br>Mol Ther (2007) 15, 1982-1990. PubMed  Europe PubMed DOI
  51. Gioia,M., Monaco,S., Fasciglione,G.F., Coletti,A., Modesti,A., Marini,S. and Coletta,M.<br>Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains<br>J Mol Biol (2007) 368, 1101-1113. PubMed  Europe PubMed DOI
  52. Sulkala,M., Tervahartiala,T., Sorsa,T., Larmas,M., Salo,T. and Tjaderhane,L.<br>Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin<br>Arch Oral Biol (2007) 52, 121-127. PubMed  Europe PubMed DOI
    53. 2006
  53. Bertini,I., Calderone,V., Fragai,M., Luchinat,C., Maletta,M. and Yeo,K.J.<br>Snapshots of the reaction mechanism of matrix metalloproteinases<br>Angew Chem Int Ed Engl (2006) 45, 7952-7955. PubMed  Europe PubMed DOI  S
  54. [YEAR:17-10-2006]Campestre,C., Agamennone,M., Tortorella,P., Preziuso,S., Biasone,A., Gavuzzo,E., Pochetti,G., Mazza,F., Hiller,O., Tschesche,H., Consalvi,V. and Gallina,C.<br>N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8<br>Bioorg Med Chem Lett (17-10-2006) 16, 20-24. PubMed  Europe PubMed DOI  S  I
  55. [YEAR:9-2-2006]Pochetti,G., Gavuzzo,E., Campestre,C., Agamennone,M., Tortorella,P., Consalvi,V., Gallina,C., Hiller,O., Tschesche,H., Tucker,P.A. and Mazza,F.<br>Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates<br>J Med Chem (9-2-2006) 49, 923-931. PubMed  Europe PubMed DOI  S  I
  56. [YEAR:1-7-2006]Van Lint,P. and Libert,C.<br>Matrix metalloproteinase-8: Cleavage can be decisive<br>Cytokine Growth Factor Rev (1-7-2006) 17, 217-223. PubMed  Europe PubMed DOI  V
    57. 2005
  57. Agamennone,M., Campestre,C., Preziuso,S., Consalvi,V., Crucianelli,M., Mazza,F., Politi,V., Ragno,R., Tortorella,P. and Gallina,C.<br>Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2<br>Eur J Med Chem (2005) 40, 271-279. PubMed  Europe PubMed DOI  I
  58. Pelman,G.R., Morrison,C.J. and Overall,C.M.<br>Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond<br>J Biol Chem (2005) 280, 2370-2377. PubMed  Europe PubMed DOI  S
  59. [YEAR:1-12-2005]Van Lint,P., Wielockx,B., Puimege,L., Noel,A., Lopez-Otin,C. and Libert,C.<br>Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis<br>J Immunol (1-12-2005) 175, 7642-7649. PubMed  Europe PubMed  K
    60. 2004
  60. Rajasekhar,L., Liou,L.B., Chan,C.Y., Tsai,W.P. and Cheng,C.Y.<br>Matrix metalloproteinase-8 in sera and from polymorphonuclear leucocytes in rheumatoid arthritis: in vitro characterization and correlation with disease activity<br>Clin Exp Rheumatol (2004) 22, 597-602. PubMed  Europe PubMed
  61. Siller-Lopez,F., Sandoval,A., Salgado,S., Salazar,A., Bueno,M., Garcia,J., Vera,J., Galvez,J., Hernandez,I., Ramos,M., Aguilar-Cordova,E. and Armendariz-Borunda,J.<br>Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis<br>Gastroenterology (2004) 126, 1122-1133. PubMed  Europe PubMed DOI
  62. Tschesche,H., Pieper,M. and Wenzel,H.<br>Neutrophil collagenase<br>[ISSN:0-12-079610-4] (2004) 2, 480-486.  V
  63. [YEAR:1-11-2004]Wang,H., Parry,S., Macones,G., Sammel,M.D., Ferrand,P.E., Kuivaniemi,H., Tromp,G., Halder,I., Shriver,M.D., Romero,R. and Strauss,J.F., III<br>Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)<br>Hum Mol Genet (1-11-2004) 13, 2659-2669. PubMed  Europe PubMed DOI  M
    64. 2003
  64. Balbin,M., Fueyo,A., Tester,A.M., Pendas,A.M., Pitiot,A.S., Astudillo,A., Overall,C.M., Shapiro,S.D. and Lopez-Otin,C.<br>Loss of collagenase-2 confers increased skin tumor susceptibility to male mice<br>Nat Genet (2003) 35, 252-257. PubMed  Europe PubMed DOI  K
  65. Van Den Steen,P.E., Husson,S.J., Proost,P., Van Damme,J. and Opdenakker,G.<br>Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase<br>Biochem Biophys Res Commun (2003) 310, 889-896. PubMed  Europe PubMed DOI
  66. Van Den Steen,P.E., Wuyts,A., Husson,S.J., Proost,P., Van Damme,J. and Opdenakker,G.<br>Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities<br>Eur J Biochem (2003) 270, 3739-3749. PubMed  Europe PubMed DOI
    67. 2002
  67. Aschi,M., Roccatano,D., Di Nola,A., Gallina,C., Gavuzzo,E., Pochetti,G., Pieper,M., Tschesche,H. and Mazza,F.<br>Computational study of the catalytic domain of human neutrophil collagenase. specific role of the S3 and S'3 subsites in the interaction with a phosphonate inhibitor<br>J Comput Aided Mol Des (2002) 16, 213-225. PubMed  Europe PubMed DOI  I
  68. Gioia,M., Fasciglione,G.F., Marini,S., D'Alessio,S., De Sanctis,G., Diekmann,O., Pieper,M., Politi,V., Tschesche,H. and Coletta,M.<br>Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain<br>J Biol Chem (2002) 277, 23123-23130. PubMed  Europe PubMed DOI
    69. 2001
  69. [YEAR:1-5-2001]Bigg,H.F., Morrison,C.J., Butler,G.S., Bogoyevitch,M.A., Wang,Z.P., Soloway,P.D. and Overall,C.M.<br>Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase<br>Cancer Res (1-5-2001) 61, 3610-3618. PubMed  Europe PubMed
  70. [YEAR:18-5-2001]Brandstetter,H., Grams,F., Glitz,D., Lang,A., Huber,R., Bode,W., Krell,H.W. and Engh,R.A.<br>The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition<br>J Biol Chem (18-5-2001) 276, 17405-17412. PubMed  Europe PubMed DOI  S  I
  71. Stix,B., Kahne,T., Sletten,K., Raynes,J., Roessner,A. and Rocken,C.<br>Proteolysis of AA amyloid fibril proteins by matrix metalloproteinases-1, -2, and -3<br>Am J Pathol (2001) 159, 561-570. PubMed  Europe PubMed DOI  PMC  EPMC
  72. [YEAR:2-11-2001]Stratmann,B., Farr,M. and Tschesche,H.<br>MMP-TIMP interaction depends on residue 2 in TIMP-4<br>FEBS Lett (2-11-2001) 507, 285-287. PubMed  Europe PubMed DOI
  73. [YEAR:11-5-2001]Zhuge,Y. and Xu,J.<br>Rac1 mediates type I collagen-dependent MMP-2 activation: role in cell invasion across collagen barrier<br>J Biol Chem (11-5-2001) 276, 16248-16256. PubMed  Europe PubMed
    74. 2000
  74. Fasciglione,G.F., Marini,S., D'Alessio,S., Politi,V. and Coletta,M.<br>pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B<br>Biophys J (2000) 79, 2138-2149. PubMed  Europe PubMed DOI  PMC  EPMC
  75. [YEAR:7-9-2000]Gavuzzo,E., Pochetti,G., Mazza,F., Gallina,C., Gorini,B., D'Alessio,S., Pieper,M., Tschesche,H. and Tucker,P.A.<br>Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design<br>J Med Chem (7-9-2000) 43, 3377-3385. PubMed  Europe PubMed DOI  S  I
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  87. Betz,M., Huxley,P., Davies,S.J., Mushtaq,Y., Pieper,M., Tschesche,H., Bode,W. and Gomis-Ruth,F.X.<br>1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile<br>Eur J Biochem (1997) 247, 356-363. PubMed  Europe PubMed  S  I
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    91. 1996
  91. Cole,A.A., Chubinskaya,S., Schumacher,B., Huch,K., Szabo,G., Yao,J., Mikecz,K., Hasty,K.A. and Kuettner,K.E.<br>Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase<br>J Biol Chem (1996) 271, 11023-11026. PubMed  Europe PubMed
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    93. 1995
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  97. Bode,W., Reinemer,P., Huber,R., Kleine,T., Schnierer,S. and Tschesche,H.<br>The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity<br>EMBO J (1994) 13, 1263-1269. PubMed  Europe PubMed  PMC  EPMC  S  I
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    107. 1992
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