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Literature for peptidase M10.002: matrix metallopeptidase-8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Deng,X., You,Y., Lv,S. and Liu,Y.
    MMP8-mediated vascular remodeling in pulmonary hypertension
    Biochim Biophys Acta Mol Basis Dis (2025) 1871, 167582-167582. PubMed  Europe PubMed DOI
  2. Zhang,D., Xu,C., Liang,M., Shao,W., Wang,P., Yang,Y. and Guo,K.
    Diagnostic Accuracy of Matrix Metalloproteinase-8 for Detecting Periodontal Disease: A Meta-Analysis
    Oral Dis (2025) PubMed  Europe PubMed DOI
    3. 2024
  3. Cathomas,F., Lin,H.Y., Chan,K.L., Li,L., Parise,L.F., Alvarez,J., Durand-de Cuttoli,R., Aubry,A.V., Muhareb,S., Desland,F., Shimo,Y., Ramakrishnan,A., Estill,M., Ferrer-Perez,C., Parise,E.M., Wilk,C.M., Kaster,M.P., Wang,J., Sowa,A., Janssen,W.G., Costi,S., Rahman,A., Fernandez,N., Campbell,M., Swirski,F.K., Nestler,E.J., Shen,L., Merad,M., Murrough,J.W. and Russo,S.J.
    Circulating myeloid-derived MMP8 in stress susceptibility and depression
    Nature (2024) 626, 1108-1115. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J.
    Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Ranta,J., Havulinna,A.S., Tervahartiala,T., Niemi,K., Aarabi,G., Vihervaara,T., Salomaa,V., Sorsa,T., Pussinen,P.J. and Salminen,A.
    Serum MMP-8 and TIMP-1 concentrations in a population-based cohort: effects of age, gender, and health status
    Front Dent Med (2024) 5, 1315596-1315596. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Yates,D.
    MMP8 and stress susceptibility
    Nat Rev Neurosci (2024) 25, 209-209. PubMed  Europe PubMed DOI
    7. 2023
  7. Atanasova,T., Stankova,T., Bivolarska,A. and Vlaykova,T.
    Matrix Metalloproteinases in Oral Health-Special Attention on MMP-8
    Biomedicines (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Port,H., Hausgaard,C.M., He,Y., Maksymowych,W.P., Wichuk,S., Sinkeviciute,D., Bay-Jensen,A.C. and Holm Nielsen,S.
    A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis
    Sci Rep (2023) 13, 21717-21717. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2022
  9. Fang,X., Duan,S.F., Hu,Z.Y., Wang,J.J., Qiu,L., Wang,F. and Chen,X.L.
    Inhibition of Matrix Metalloproteinase-8 Protects Against Sepsis Serum Mediated Leukocyte Adhesion
    Front Med (Lausanne) (2022) 9, 814890-814890. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Gu,H., Peng,J., Wang,M., Guo,Z., Huang,H. and Yan,L.
    MicroRNA-320-3p promotes the progression of acute pancreatitis by blocking DNMT3a-mediated MMP8 methylation in a targeted manner
    Mol Immunol (2022) 151, 84-94. PubMed  Europe PubMed DOI
  11. Lahteenmaki,H., Tervahartiala,T., Raisanen,I.T., Parnanen,P., Mauramo,M., Gupta,S., Sampson,V., Rathnayake,N., Heikkinen,A.M., Alassiri,S., Gieselmann,D.R., Frankenberger,R. and Sorsa,T.
    Active MMP-8 point-of-care (PoC)/chairside enzyme-test as an adjunctive tool for early and real-time diagnosis of peri-implantitis
    Clin Exp Dent Res (2022) 8, 485-496. PubMed  Europe PubMed DOI  L
  12. Lee,M.R., Chen,Y.L., Wu,C.W., Chen,L.C., Chang,L.Y., Chen,J.Y., Huang,Y.T., Wang,J.Y., Shih,J.Y. and Yu,C.J.
    Toll-like receptor and matrix metalloproteinase single-nucleotide polymorphisms, haplotypes, and polygenic risk score differentiated between tuberculosis disease and infection
    Int J Infect Dis (2022) 125, 61-66. PubMed  Europe PubMed DOI  M
  13. Samulenas,G., Insodaite,R., Kunceviciene,E., Poceviciute,R., Masionyte,L., Zitkeviciute,U., Pilipaityte,L. and Smalinskiene,A.
    The Role of Functional Polymorphisms in the Extracellular Matrix Modulation-Related Genes on Dupuytren's Contracture
    Genes (Basel) (2022) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  14. Umeizudike,K.A., Lahteenmaki,H., Raisanen,I.T., Taylor,J.J., Preshaw,P.M., Bissett,S.M., Tervahartiala,T., Nwhator,O., Parnanen,P. and Sorsa,T.
    Ability of matrix metalloproteinase-8 biosensor, IFMA, and ELISA immunoassays to differentiate between periodontal health, gingivitis, and periodontitis
    J Periodontal Res (2022) 57, 558-567. PubMed  Europe PubMed DOI
  15. Zhang,C., Niu,K., Ren,M., Zhou,X., Yang,Z., Yang,M., Wang,X., Luo,J., Shao,Y., Zhang,C., Chen,D., Gao,S., Ge,S., Wu,Q. and Xiao,Q.
    Targeted Inhibition of Matrix Metalloproteinase-8 Prevents Aortic Dissection in a Murine Model
    Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2021
  16. Bassiouni,W., Ali,M.A.M. and Schulz,R.
    Multifunctional intracellular matrix metalloproteinases: implications in disease
    FEBS J (2021) 288, 7162-7182. PubMed  Europe PubMed DOI  V
  17. Guti,S., Baidya,S.K., Banerjee,S., Adhikari,N. and Jha,T.
    A robust classification-dependent multi-molecular modelling study on some biphenyl sulphonamide based MMP-8 inhibitors
    SAR QSAR Environ Res (2021) 32, 835-861. PubMed  Europe PubMed DOI  I
  18. Hernandez,M., Baeza,M., Raisanen,I.T., Contreras,J., Tervahartiala,T., Chaparro,A., Sorsa,T. and Hernandez-Rios,P.
    Active MMP-8 Quantitative Test as an Adjunctive Tool for Early Diagnosis of Periodontitis
    Diagnostics (Basel) (2021) 11, 1503-1503. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Petain,S., Kasnak,G., Firatli,E., Tervahartiala,T., Gursoy,U.K. and Sorsa,T.
    Periodontitis and peri-implantitis tissue levels of Treponema denticola-CTLP and its MMP-8 activating ability
    Acta Histochem (2021) 123, 151767-151767. PubMed  Europe PubMed DOI
  20. Wang,X., Zhang,D., Fucci,Q.A., Dollery,C.M. and Owen,C.A.
    Surface-bound matrix metalloproteinase-8 on macrophages: Contributions to macrophage pericellular proteolysis and migration through tissue barriers
    Physiol Rep (2021) 9, e14778-e14778. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2020
  21. Morla,S. and Desai,U.R.
    Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8
    Biomolecules (2020) 10, 1166-1166. PubMed  Europe PubMed DOI  PMC  EPMC  I
  22. Pan,S., Zhang,Z., Li,C. and Yang,D.
    Interleukin-25 regulates matrix metalloproteinase-2 and -9 expression in periodontal fibroblast cells through ERK and P38MAPK pathways
    Cell Biol Int (2020) PubMed  Europe PubMed DOI
  23. Roy,H.S., Dubey,G., Sharma,V.K., Bharatam,P.V. and Ghosh,D.
    Molecular docking and molecular dynamics to identify collagenase inhibitors as lead compounds to address osteoarthritis
    J Biomol Struct Dyn (2020) , 1-13. PubMed  Europe PubMed DOI  I
  24. Wu,W., Peng,S., Shi,Y., Li,L., Song,Z. and Lin,S.
    NPY promotes macrophage migration by upregulating matrix metalloproteinase-8 expression
    J Cell Physiol (2020) 236, 1903-1912. PubMed  Europe PubMed DOI
    25. 2019
  25. Abu Bakar,A.R., Ripen,A.M., Merican,A.F. and Mohamad,S.B.
    Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
    Nat Prod Res (2019) 33, 1765-1768. PubMed  Europe PubMed DOI  I
    26. 2018
  26. Kumar,H., Jo,M.J., Choi,H., Muttigi,M.S., Shon,S., Kim,B.J., Lee,S.H. and Han,I.B.
    Matrix metalloproteinase-8 inhibition prevents disruption of blood-spinal cord barrier and attenuates inflammation in rat model of spinal cord injury
    Mol Neurobiol (2018) 55, 2577-2590. PubMed  Europe PubMed DOI  I
    27. 2017
  27. Inanc,S., Keles,D. and Oktay,G.
    An improved collagen zymography approach for evaluating the collagenases MMP-1, MMP-8, and MMP-13
    Biotechniques (2017) 63, 174-180. PubMed  Europe PubMed DOI  L
    28. 2016
  28. Demeestere,D., Dejonckheere,E., Steeland,S., Hulpiau,P., Haustraete,J., Devoogdt,N., Wichert,R., Becker-Pauly,C., Van Wonterghem,E., Dewaele,S., Van Imschoot,G., Aerts,J., Arckens,L., Saeys,Y., Libert,C. and Vandenbroucke,R.E.
    Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8
    Mol Ther (2016) 24, 890-902. PubMed  Europe PubMed DOI
  29. Han,J.E., Lee,E.J., Moon,E., Ryu,J.H., Choi,J.W. and Kim,H.S.
    Matrix metalloproteinase-8 is a novel pathogenetic factor in focal cerebral ischemia
    Mol Neurobiol (2016) 53, 231-239. PubMed  Europe PubMed DOI  K
  30. Tucker,J.K., McNiff,M.L., Ulapane,S.B., Spencer,P., Laurence,J.S. and Berrie,C.L.
    Mechanistic investigations of matrix metalloproteinase-8 inhibition by metal abstraction peptide
    Biointerphases (2016) 11, 021006-021006. PubMed  Europe PubMed DOI  I
    31. 2015
  31. Salminen,A., Astrom,P., Metso,J., Soliymani,R., Salo,T., Jauhiainen,M., Pussinen,P.J. and Sorsa,T.
    Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux capacity
    FASEB J (2015) 29, 1435-1445. PubMed  Europe PubMed DOI
  32. Wen,G., Zhang,C., Chen,Q., Luong,l.A., Mustafa,A., Ye,S. and Xiao,Q.
    A novel role of matrix metalloproteinase-8 in macrophage differentiation and polarization
    J Biol Chem (2015) 290, 19158-19172. PubMed  Europe PubMed DOI
    33. 2014
  33. Arnett,E., Vadia,S., Nackerman,C.C., Oghumu,S., Satoskar,A.R., McLeish,K.R., Uriarte,S.M. and Seveau,S.
    The pore-forming toxin listeriolysin O is degraded by neutrophil metalloproteinase-8 and fails to mediate Listeria monocytogenes intracellular survival in neutrophils
    J Immunol (2014) 192, 234-244. PubMed  Europe PubMed DOI
  34. Ding,D., Lichtenwalter,K., Pi,H., Mobashery,S. and Chang,M.
    Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)
    MedChemComm (2014) 5, 1381-1383. DOI  I
  35. Kalva,S., Vinod,D. and Saleena,L.M.
    Combined structure- and ligand-based pharmacophore modeling and molecular dynamics simulation studies to identify selective inhibitors of MMP-8
    J Mol Model (2014) 20, 2191-2191. PubMed  Europe PubMed DOI  I
  36. Lee,E.J., Han,J.E., Woo,M.S., Shin,J.A., Park,E.M., Kang,J.L., Moon,P.G., Baek,M.C., Son,W.S., Ko,Y.T., Choi,J.W. and Kim,H.S.
    Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-alpha activation
    J Immunol (2014) 193, 2384-2393. PubMed  Europe PubMed DOI
    37. 2013
  37. Chakrabarti,B., Bairagya,H.R., Mishra,D.K., Chatterjee,P.K. and Mukhopadhyay,B.P.
    Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human matrix metalloproteinase-8 enzyme: A study by MD-simulation methods
    Bioinformation (2013) 9, 126-133. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Hugenberg,V., Riemann,B., Hermann,S., Schober,O., Schafers,M., Szardenings,K., Lebedev,A., Gangadharmath,U., Kolb,H., Walsh,J., Zhang,W., Kopka,K. and Wagner,S.
    Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (Radio)synthesis, in vitro and first in vivo evaluation
    J Med Chem (2013) 56, 6858-6870. PubMed  Europe PubMed DOI  I
  39. Lu,K.G. and Stultz,C.M.
    Insight into the degradation of type-I collagen fibrils by MMP-8
    J Mol Biol (2013) 425, 1815-1825. PubMed  Europe PubMed DOI
  40. Mori,M., Massaro,A., Calderone,V., Fragai,M., Luchinat,C. and Mordini,A.
    Discovery of a new class of potent MMP inhibitors by structure-based optimization of the arylsulfonamide scaffold
    ACS Med Chem Lett (2013) 4, 565-569. PubMed  Europe PubMed DOI  I
    41. 2012
  41. Solan,P.D., Dunsmore,K.E., Denenberg,A.G., Odoms,K., Zingarelli,B. and Wong,H.R.
    A novel role for matrix metalloproteinase-8 in sepsis
    Crit Care Med (2012) 40, 379-387. PubMed  Europe PubMed DOI  K
  42. Tschesche,H. and Wenzel,H.
    Neutrophil collagenase
    [ISSN:978-0-12-407744-7] (2012) 3, 725-734. DOI
    43. 2011
  43. Robichaud,T.K., Steffensen,B. and Fields,G.B.
    Exosite interactions impact matrix metalloproteinase collagen specificities
    J Biol Chem (2011) 286, 37535-37542. PubMed  Europe PubMed DOI  P
    44. 2010
  44. Devel,L., Czarny,B., Beau,F., Georgiadis,D., Stura,E. and Dive,V.
    Third generation of matrix metalloprotease inhibitors: gain in selectivity by targeting the depth of the S1' cavity
    Biochimie (2010) 92, 1501-1508. PubMed  Europe PubMed DOI  I
  45. Garcia,S., Forteza,J., Lopez-Otin,C., Gomez-Reino,J.J., Gonzalez,A. and Conde,C.
    Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model
    Arthritis Res Ther (2010) 12, R224-R224. PubMed  Europe PubMed DOI  K
    46. 2009
  46. Lopez-Otin,C., Palavalli,L.H. and Samuels,Y.
    Protective roles of matrix metalloproteinases: from mouse models to human cancer
    Cell Cycle (2009) 8, 3657-3662. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Palavalli,L.H., Prickett,T.D., Wunderlich,J.R., Wei,X., Burrell,A.S., Porter-Gill,P., Davis,S., Wang,C., Cronin,J.C., Agrawal,N.S., Lin,J.C., Westbroek,W., Hoogstraten-Miller,S., Molinolo,A.A., Fetsch,P., Filie,A.C., O'Connell,M.P., Banister,C.E., Howard,J.D., Buckhaults,P., Weeraratna,A.T., Brody,L.C., Rosenberg,S.A. and Samuels,Y.
    Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma
    Nat Genet (2009) 41, 518-520. PubMed  Europe PubMed DOI  PMC  EPMC  M
  48. Pochetti,G., Montanari,R., Gege,C., Chevrier,C., Taveras,A.G. and Mazza,F.
    Extra binding region induced by non-zinc chelating inhibitors into the S1' subsite of matrix metalloproteinase 8 (MMP-8)
    J Med Chem (2009) 52, 1040-1049. PubMed  Europe PubMed DOI  S  I
    49. 2007
  49. [YEAR:25-1-2007]Aschi,M., Besker,N., Re,N., Pochetti,G., Coletti,C., Gallina,C. and Mazza,F.
    Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations
    J Med Chem (25-1-2007) 50, 211-218. PubMed  Europe PubMed DOI  I
  50. Cheng,J., Sauthoff,H., Huang,Y., Kutler,D.I., Bajwa,S., Rom,W.N. and Hay,J.G.
    Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus
    Mol Ther (2007) 15, 1982-1990. PubMed  Europe PubMed DOI
  51. Gioia,M., Monaco,S., Fasciglione,G.F., Coletti,A., Modesti,A., Marini,S. and Coletta,M.
    Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains
    J Mol Biol (2007) 368, 1101-1113. PubMed  Europe PubMed DOI
  52. Sulkala,M., Tervahartiala,T., Sorsa,T., Larmas,M., Salo,T. and Tjaderhane,L.
    Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin
    Arch Oral Biol (2007) 52, 121-127. PubMed  Europe PubMed DOI
    53. 2006
  53. Bertini,I., Calderone,V., Fragai,M., Luchinat,C., Maletta,M. and Yeo,K.J.
    Snapshots of the reaction mechanism of matrix metalloproteinases
    Angew Chem Int Ed Engl (2006) 45, 7952-7955. PubMed  Europe PubMed DOI  S
  54. [YEAR:17-10-2006]Campestre,C., Agamennone,M., Tortorella,P., Preziuso,S., Biasone,A., Gavuzzo,E., Pochetti,G., Mazza,F., Hiller,O., Tschesche,H., Consalvi,V. and Gallina,C.
    N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8
    Bioorg Med Chem Lett (17-10-2006) 16, 20-24. PubMed  Europe PubMed DOI  S  I
  55. [YEAR:9-2-2006]Pochetti,G., Gavuzzo,E., Campestre,C., Agamennone,M., Tortorella,P., Consalvi,V., Gallina,C., Hiller,O., Tschesche,H., Tucker,P.A. and Mazza,F.
    Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates
    J Med Chem (9-2-2006) 49, 923-931. PubMed  Europe PubMed DOI  S  I
  56. [YEAR:1-7-2006]Van Lint,P. and Libert,C.
    Matrix metalloproteinase-8: Cleavage can be decisive
    Cytokine Growth Factor Rev (1-7-2006) 17, 217-223. PubMed  Europe PubMed DOI  V
    57. 2005
  57. Agamennone,M., Campestre,C., Preziuso,S., Consalvi,V., Crucianelli,M., Mazza,F., Politi,V., Ragno,R., Tortorella,P. and Gallina,C.
    Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2
    Eur J Med Chem (2005) 40, 271-279. PubMed  Europe PubMed DOI  I
  58. Pelman,G.R., Morrison,C.J. and Overall,C.M.
    Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond
    J Biol Chem (2005) 280, 2370-2377. PubMed  Europe PubMed DOI  S
  59. [YEAR:1-12-2005]Van Lint,P., Wielockx,B., Puimege,L., Noel,A., Lopez-Otin,C. and Libert,C.
    Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis
    J Immunol (1-12-2005) 175, 7642-7649. PubMed  Europe PubMed  K
    60. 2004
  60. Rajasekhar,L., Liou,L.B., Chan,C.Y., Tsai,W.P. and Cheng,C.Y.
    Matrix metalloproteinase-8 in sera and from polymorphonuclear leucocytes in rheumatoid arthritis: in vitro characterization and correlation with disease activity
    Clin Exp Rheumatol (2004) 22, 597-602. PubMed  Europe PubMed
  61. Siller-Lopez,F., Sandoval,A., Salgado,S., Salazar,A., Bueno,M., Garcia,J., Vera,J., Galvez,J., Hernandez,I., Ramos,M., Aguilar-Cordova,E. and Armendariz-Borunda,J.
    Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis
    Gastroenterology (2004) 126, 1122-1133. PubMed  Europe PubMed DOI
  62. Tschesche,H., Pieper,M. and Wenzel,H.
    Neutrophil collagenase
    [ISSN:0-12-079610-4] (2004) 2, 480-486.  V
  63. [YEAR:1-11-2004]Wang,H., Parry,S., Macones,G., Sammel,M.D., Ferrand,P.E., Kuivaniemi,H., Tromp,G., Halder,I., Shriver,M.D., Romero,R. and Strauss,J.F., III
    Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)
    Hum Mol Genet (1-11-2004) 13, 2659-2669. PubMed  Europe PubMed DOI  M
    64. 2003
  64. Balbin,M., Fueyo,A., Tester,A.M., Pendas,A.M., Pitiot,A.S., Astudillo,A., Overall,C.M., Shapiro,S.D. and Lopez-Otin,C.
    Loss of collagenase-2 confers increased skin tumor susceptibility to male mice
    Nat Genet (2003) 35, 252-257. PubMed  Europe PubMed DOI  K
  65. Van Den Steen,P.E., Husson,S.J., Proost,P., Van Damme,J. and Opdenakker,G.
    Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase
    Biochem Biophys Res Commun (2003) 310, 889-896. PubMed  Europe PubMed DOI
  66. Van Den Steen,P.E., Wuyts,A., Husson,S.J., Proost,P., Van Damme,J. and Opdenakker,G.
    Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities
    Eur J Biochem (2003) 270, 3739-3749. PubMed  Europe PubMed DOI
    67. 2002
  67. Aschi,M., Roccatano,D., Di Nola,A., Gallina,C., Gavuzzo,E., Pochetti,G., Pieper,M., Tschesche,H. and Mazza,F.
    Computational study of the catalytic domain of human neutrophil collagenase. specific role of the S3 and S'3 subsites in the interaction with a phosphonate inhibitor
    J Comput Aided Mol Des (2002) 16, 213-225. PubMed  Europe PubMed DOI  I
  68. Gioia,M., Fasciglione,G.F., Marini,S., D'Alessio,S., De Sanctis,G., Diekmann,O., Pieper,M., Politi,V., Tschesche,H. and Coletta,M.
    Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain
    J Biol Chem (2002) 277, 23123-23130. PubMed  Europe PubMed DOI
    69. 2001
  69. [YEAR:1-5-2001]Bigg,H.F., Morrison,C.J., Butler,G.S., Bogoyevitch,M.A., Wang,Z.P., Soloway,P.D. and Overall,C.M.
    Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase
    Cancer Res (1-5-2001) 61, 3610-3618. PubMed  Europe PubMed
  70. [YEAR:18-5-2001]Brandstetter,H., Grams,F., Glitz,D., Lang,A., Huber,R., Bode,W., Krell,H.W. and Engh,R.A.
    The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition
    J Biol Chem (18-5-2001) 276, 17405-17412. PubMed  Europe PubMed DOI  S  I
  71. Stix,B., Kahne,T., Sletten,K., Raynes,J., Roessner,A. and Rocken,C.
    Proteolysis of AA amyloid fibril proteins by matrix metalloproteinases-1, -2, and -3
    Am J Pathol (2001) 159, 561-570. PubMed  Europe PubMed DOI  PMC  EPMC
  72. [YEAR:2-11-2001]Stratmann,B., Farr,M. and Tschesche,H.
    MMP-TIMP interaction depends on residue 2 in TIMP-4
    FEBS Lett (2-11-2001) 507, 285-287. PubMed  Europe PubMed DOI
  73. [YEAR:11-5-2001]Zhuge,Y. and Xu,J.
    Rac1 mediates type I collagen-dependent MMP-2 activation: role in cell invasion across collagen barrier
    J Biol Chem (11-5-2001) 276, 16248-16256. PubMed  Europe PubMed
    74. 2000
  74. Fasciglione,G.F., Marini,S., D'Alessio,S., Politi,V. and Coletta,M.
    pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B
    Biophys J (2000) 79, 2138-2149. PubMed  Europe PubMed DOI  PMC  EPMC
  75. [YEAR:7-9-2000]Gavuzzo,E., Pochetti,G., Mazza,F., Gallina,C., Gorini,B., D'Alessio,S., Pieper,M., Tschesche,H. and Tucker,P.A.
    Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design
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