Sequence features for peptidase M10.002: matrix metallopeptidase-8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0690174 Acanthisitta chloris 466 98-276 E219 H218, H222, H228 GENBANK:XP_009076258
MER1203084 Acanthisitta chloris 467 100-279 E220 H219, H223, H229 GENBANK:KFP70751
MER1203078 Acinonyx jubatus 476 110-287 E229 H228, H232, H238 GENBANK:XP_014929409
MER0290851 Ailuropoda melanoleuca 475 110-287 E229 H228, H232, H238 GENBANK:XP_002922069
MER0269521 Alligator mississippiensis 466 98-278 E219 H218, H222, H228 GENBANK:XP_006272556
MER1203095 Alligator mississippiensis 462 96-274 E215 H214, H218, H224 GENBANK:KYO44958
MER1203127 Alligator mississippiensis 381 13-192 E134 H133, H137, H143 GENBANK:KYO44959
MER1203157 Alligator mississippiensis 356 4-167 E109 H108, H112, H118 GENBANK:XP_019337495
MER1203420 Alligator mississippiensis 342 4-153 E95 H94, H98, H104 GENBANK:KYO44960
MER0296274 Alligator sinensis 466 98-278 E219 H218, H222, H228 GENBANK:XP_006038117
MER0290865 Anolis carolinensis 465 98-276 E218 H217, H221, H227 GENBANK:XP_003219341
MER1203120 Anser cygnoides 466 99-278 E219 H218, H222, H228 GENBANK:XP_013033641
MER1203059 Antrostomus carolinensis 467 100-279 E220 H219, H223, H229 GENBANK:KFZ52511
MER1203087 Aotus nancymaae 465 99-277 E218 H217, H221, H227 GENBANK:XP_012310575
MER0687582 Aptenodytes forsteri 466 98-276 E219 H218, H222, H228 GENBANK:XP_009272902
MER0686664 Aquila chrysaetos 466 98-276 E219 H218, H222, H228 GENBANK:XP_011594083
MER0403044 Balaenoptera acutorostrata 468 100-468 E221 H220, H224, H230 GENBANK:XP_007191286
MER0682225 Balearica regulorum 468 102-278 E221 H220, H224, H230 UNIPROT:A0A087VAS0
MER0682225 Balearica regulorum 468 102-278 E221 H220, H224, H230 UNIPROT:A0A087VAS0
MER1203066 Bambusicola thoracica 284 33-212 E153 H152, H156, H162 GENBANK:POI25069
MER0190774 Bos grunniens 470 102-279 E221 H220, H224, H230 GENBANK:ELR53688
MER0195766 Bos taurus 494 100-278 E221 H220, H224, H230 GENBANK:DAA22479
MER1205124 Branchiostoma belcheri 592 146-306 E261 H260, H264, H270 GENBANK:XP_019620911
MER1203140 Callipepla squamata 1457 1090-1269 E1210 H1209, H1213, H1219 GENBANK:OXB57866
MER0290856 Callithrix jacchus 465 97-277 E218 H217, H221, H227 UNIPROT:F7DGR3
MER0290856 Callithrix jacchus 465 97-277 E218 H217, H221, H227 UNIPROT:F7DGR3
MER1203134 Camelus bactrianus 470 102-279 E221 H220, H224, H230 GENBANK:XP_010951492
MER0676414 Camelus dromedarius 470 100-278 E221 H220, H224, H230 GENBANK:XP_010976091
MER0825125 Camelus ferus 751 105-262 E216, E460 H215, H459, H463, H219, H469, H225 UNIPROT:S9WV44
MER0825125 Camelus ferus 751 105-262 E216, E460 H215, H459, H463, H219, H469, H225 UNIPROT:S9WV44
MER1203130 Camelus ferus 402 34-211 E153 H152, H156, H162 GENBANK:XP_014415935
MER0053696 Canis lupus familiaris 476 108-287 E229 H228, H232, H238 UNIPROT:F1PVR0
MER0053696 Canis lupus familiaris 476 108-287 E229 H228, H232, H238 UNIPROT:F1PVR0
MER1203086 Castor canadensis 468 100-279 E221 H220, H224, H230 GENBANK:XP_020023669
MER0825146 Cathartes aura 468 110-272 E221 H220, H224, H230 UNIPROT:A0A091MFR7
MER0825146 Cathartes aura 468 110-272 E221 H220, H224, H230 UNIPROT:A0A091MFR7
MER1203058 Cebus capucinus 465 99-277 E218 H217, H221, H227 GENBANK:XP_017400262
MER1203108 Ceratotherium simum 474 100-283 E225 H224, H228, H234 GENBANK:XP_014640696
MER1203032 Cercocebus atys 476 108-286 E227 H226, H230, H236 GENBANK:XP_011921976
MER1203129 Colinus virginianus 770 99-278 E219 H218, H222, H228 GENBANK:OXB72006
MER0671445 Colius striatus 433 98-276 E219 H218, H222, H228 GENBANK:XP_010197938
MER0670301 Colobus angolensis 467 97-275 E218 H217, H221, H227 GENBANK:XP_011782020
MER0190769 Columba livia 433 66-245 E186 H185, H189, H195 GENBANK:EMC80516
MER0668331 Corvus cornix 400 34-210 E153 H152, H156, H162 GENBANK:XP_010398897
MER1203115 Coturnix japonica 466 99-278 E219 H218, H222, H228 GENBANK:XP_015707753
MER0290866 Cricetulus griseus 600 101-278 E220 H219, H223, H229 GENBANK:XP_003496193
MER0290896 Cricetulus griseus 966 746-851 E180, E554, E806 H805, H179, H553, H809, H183, H557, H563, H815, H189 UNIPROT:G3GUV4
MER0290896 Cricetulus griseus 966 746-851 E180, E554, E806 H805, H179, H553, H809, H183, H557, H563, H815, H189 UNIPROT:G3GUV4
MER1203110 Crocodylus porosus 466 100-277 E219 H218, H222, H228 GENBANK:XP_019385813
MER1203118 Crocodylus porosus 462 96-274 E215 H214, H218, H224 GENBANK:XP_019385815
MER0665125 Cuculus canorus 466 98-276 E219 H218, H222, H228 GENBANK:XP_009554379
MER1206519 Cyprinus carpio 119 22-118 E74, H73, H77, H83, GENBANK:KTF94833
MER1203015 Delphinapterus leucas 468 102-279 E221 H220, H224, H230 GENBANK:XP_022416256
MER1203105 Dipodomys ordii 453 88-265 E206 H205, H209, H215 GENBANK:XP_012865025
MER1203136 Echinops telfairi 471 104-282 E224 H223, H227, H233 GENBANK:XP_012861692
MER1203017 Enhydra lutris 467 102-279 E221 H220, H224, H230 GENBANK:XP_022368736
MER1203128 Equus asinus 501 133-312 E254 H253, H257, H263 GENBANK:XP_014715503
MER1204270 Equus asinus 447 133-241 missing missing, missing, missing GENBANK:XP_014715504
MER0098642 Equus caballus 471 100-280 E222 H221, H225, H231 GENBANK:XP_001498886
MER1203124 Equus caballus 411 41-220 E162 H161, H165, H171 GENBANK:XP_023500481
MER0329236 Felis catus 468 102-279 E221 H220, H224, H230 UNIPROT:M3WNA0
MER0329236 Felis catus 468 102-279 E221 H220, H224, H230 UNIPROT:M3WNA0
MER0656639 Fukomys damarensis 470 100-278 E221 H220, H224, H230 GENBANK:XP_010640353
MER0655127 Fulmarus glacialis 466 98-278 E219 H218, H222, H228 GENBANK:XP_009583185
MER0654032 Gavia stellata 466 98-276 E219 H218, H222, H228 GENBANK:XP_009808362
MER1203065 Gavialis gangeticus 400 34-212 E153 H152, H156, H162 GENBANK:XP_019381032
MER1203099 Gavialis gangeticus 466 100-277 E219 H218, H222, H228 GENBANK:XP_019381030
MER0329206 Gorilla gorilla 467 99-277 E218 H217, H221, H227 UNIPROT:G3R051
MER0329206 Gorilla gorilla 467 99-277 E218 H217, H221, H227 UNIPROT:G3R051
MER1203046 Gorilla gorilla 444 76-254 E195 H194, H198, H204 GENBANK:XP_018891525
MER0652878 Haliaeetus albicilla 466 98-276 E219 H218, H222, H228 GENBANK:XP_009911929
MER0651353 Haliaeetus leucocephalus 466 98-276 E219 H218, H222, H228 GENBANK:XP_010560425
MER0290853 Heterocephalus glaber 470 102-279 E221 H220, H224, H230 UNIPROT:G5BUC2
MER0290853 Heterocephalus glaber 470 102-279 E221 H220, H224, H230 UNIPROT:G5BUC2
MER1203062 Heterocephalus glaber 382 14-191 E133 H132, H136, H142 GENBANK:XP_021104687
MER1203019 Hipposideros armiger 470 102-281 E223 H222, H226, H232 GENBANK:XP_019487809
MER0001084 Homo sapiens 467 97-275 E218 H217, H221, H227 GENBANK:XP_011541136
MER0001084 Homo sapiens 467 97-275 E218 H217, H221, H227 GENBANK:XP_011541136
MER0001084 Homo sapiens 467 97-275 E218 H217, H221, H227 GENBANK:XP_011541136
MER0611721 Latimeria chalumnae 410 76-394 E187 H186, H190, H196 GENBANK:XP_005998667
MER0290870 Loxodonta africana 471 102-280 E221 H220, H224, H230 GENBANK:XP_003415714
MER0290852 Macaca fascicularis 467 99-277 E218 H217, H221, H227 UNIPROT:G7PNK2
MER0290852 Macaca fascicularis 467 99-277 E218 H217, H221, H227 UNIPROT:G7PNK2
MER1203048 Macaca fascicularis 476 108-286 E227 H226, H230, H236 GENBANK:XP_015291126
MER0112728 Macaca mulatta 467 97-275 E218 H217, H221, H227 GENBANK:XP_001098000
MER1203060 Macaca mulatta 476 108-286 E227 H226, H230, H236 GENBANK:XP_014971041
MER0647467 Manacus vitellinus 466 98-276 E219 H218, H222, H228 GENBANK:XP_008921010
MER0645614 Mandrillus leucophaeus 467 97-275 E218 H217, H221, H227 GENBANK:XP_011839790
MER1203023 Manis javanica 468 102-279 E221 H220, H224, H230 GENBANK:XP_017521714
MER1203121 Marmota marmota 469 102-278 E220 H219, H223, H229 GENBANK:XP_015345430
MER0290861 Meleagris gallopavo 466 99-278 E219 H218, H222, H228 GENBANK:XP_003203529
MER1203139 Meriones unguiculatus 467 101-278 E220 H219, H223, H229 GENBANK:XP_021484219
MER0012232 Mesocricetus auratus 68 1-68 E44 H43, H47, H53 UNIPROT:Q9JM43
MER0012232 Mesocricetus auratus 68 1-68 E44 H43, H47, H53 UNIPROT:Q9JM43
MER1203101 Miniopterus natalensis 467 100-279 E221 H220, H224, H230 GENBANK:XP_016062205
MER1203109 Mus caroli 466 100-278 E219 H218, H222, H228 GENBANK:XP_021027997
MER0004500 Mus musculus 465 97-275 E218 H217, H221, H227 UNIPROT:O70138
MER0004500 Mus musculus 465 97-275 E218 H217, H221, H227 UNIPROT:O70138
MER0004500 Mus musculus 465 97-275 E218 H217, H221, H227 UNIPROT:O70138
MER1203100 Mus pahari 468 102-280 E221 H220, H224, H230 GENBANK:XP_021061921
MER0290850 Mustela putorius 247 33-210 E152 H151, H155, H161 UNIPROT:G9KAY1
MER0290850 Mustela putorius 247 33-210 E152 H151, H155, H161 UNIPROT:G9KAY1
MER1203014 Mustela putorius 472 107-284 E226 H225, H229, H235 GENBANK:XP_012917886
MER1203042 Myotis brandtii 400 33-211 E153 H152, H156, H162 GENBANK:XP_014400075
MER1203070 Myotis davidii 485 101-279 E221 H220, H224, H230 GENBANK:XP_015426929
MER1203051 Myotis lucifugus 465 98-276 E218 H217, H221, H227 GENBANK:XP_023614610
MER0614111 Nannospalax galili 469 99-277 E220 H219, H223, H229 GENBANK:XP_008828293
MER1203076 Neomonachus schauinslandi 477 111-288 E230 H229, H233, H239 GENBANK:XP_021552027
MER1203145 Neotoma lepida 948 101-278 E220 H219, H223, H229 GENBANK:OBS70043
MER0825092 Neovison vison 265 71-230 E182 H181, H185, H191 UNIPROT:U6DJE4
MER0825092 Neovison vison 265 71-230 E182 H181, H185, H191 UNIPROT:U6DJE4
MER0257633 Nomascus leucogenys 517 147-327 E268 H267, H271, H277 GENBANK:XP_003253514
MER0634762 Notothenia coriiceps 164 9-154 E110 H109, H113, H119 GENBANK:XP_010765237
MER1203097 Numida meleagris 467 100-279 E220 H219, H223, H229 GENBANK:XP_021236581
MER1203075 Odocoileus virginianus 470 102-279 E221 H220, H224, H230 GENBANK:XP_020739074
MER1204252 Odocoileus virginianus 414 100-205 missing missing, missing, missing GENBANK:XP_020739073
MER0825022 Ophiophagus hannah 404 109-270 E221 H220, H224, H230 UNIPROT:V8NUV1
MER0825022 Ophiophagus hannah 404 109-270 E221 H220, H224, H230 UNIPROT:V8NUV1
MER0097788 Ornithorhynchus anatinus 629 97-274 E216, E470 H469, H215, H219, H473, H225, H479 GENBANK:XP_001509994
MER0097789 Ornithorhynchus anatinus 629 458-527 E216, E470 H469, H215, H473, H219, H479, H225 GENBANK:XP_001509994
MER0826608 Ornithorhynchus anatinus 573 58-374 E322 H321, H325, H331 UNIPROT:F7B2W9
MER0290883 Oryctolagus cuniculus 408 49-219 E161 H160, H164, H170 GENBANK:XP_002708467
MER0256232 Otolemur garnettii 465 97-277 E218 H217, H221, H227 UNIPROT:H0XCW8
MER0256232 Otolemur garnettii 465 97-277 E218 H217, H221, H227 UNIPROT:H0XCW8
MER1203142 Ovis ammon musimon 470 102-269 E221 H220, H224, H230 GENBANK:XP_012008196
MER0329254 Ovis aries 470 102-279 E221 H220, H224, H230 GENBANK:XP_004016575
MER0341941 Pan paniscus 467 99-277 E218 H217, H221, H227 GENBANK:XP_003828427
MER1203034 Pan troglodytes 444 76-254 E195 H194, H198, H204 GENBANK:XP_016777366
MER1203090 Panthera pardus 476 110-287 E229 H228, H232, H238 GENBANK:XP_019289237
MER0329101 Papio anubis 467 99-277 E218 H217, H221, H227 UNIPROT:A0A096NQR7
MER0329101 Papio anubis 467 99-277 E218 H217, H221, H227 UNIPROT:A0A096NQR7
MER1203020 Papio anubis 476 108-286 E227 H226, H230, H236 GENBANK:XP_009185434
MER1203823 Paramormyrops kingsleyae 498 131-308 E246 H245, H249, H255 GENBANK:XP_023700747
MER1203068 Patagioenas fasciata 465 98-277 E218 H217, H221, H227 GENBANK:OPJ68645
MER1203111 Peromyscus maniculatus 469 101-278 E220 H219, H223, H229 GENBANK:XP_006983830
MER0632257 Phaethon lepturus 465 97-275 E218 H217, H221, H227 GENBANK:XP_010280672
MER0631651 Phalacrocorax carbo 466 98-276 E219 H218, H222, H228 GENBANK:XP_009512512
MER1203043 Phalacrocorax carbo 467 100-279 E220 H219, H223, H229 GENBANK:KFW95931
MER1203080 Phascolarctos cinereus 468 99-277 E219 H218, H222, H228 GENBANK:XP_020851846
MER0629460 Picoides pubescens 466 98-278 E219 H218, H222, H228 GENBANK:XP_009894707
MER1203082 Piliocolobus tephrosceles 467 99-277 E218 H217, H221, H227 GENBANK:XP_023063898
MER0341944 Pongo abelii 465 98-277 E218 H217, H221, H227 GENBANK:XP_003777917
MER1203025 Pongo abelii 467 98-277 E218 H217, H221, H227 GENBANK:XP_024111234
MER1203077 Propithecus coquereli 465 98-277 E218 H217, H221, H227 GENBANK:XP_012514613
MER1203132 Protobothrops mucrosquamatus 973 101-280 E221 H220, H224, H230 GENBANK:XP_015670206
MER0553740 Pterocles gutturalis 465 97-275 E218 H217, H221, H227 UNIPROT:A0A093DMB1
MER0553740 Pterocles gutturalis 465 97-275 E218 H217, H221, H227 UNIPROT:A0A093DMB1
MER1203757 Pygocentrus nattereri 490 121-290 E232 H231, H235, H241 GENBANK:XP_017563172
MER0824928 Pygoscelis adeliae 467 108-271 E220 H219, H223, H229 UNIPROT:A0A093R4E1
MER0824928 Pygoscelis adeliae 467 108-271 E220 H219, H223, H229 UNIPROT:A0A093R4E1
MER1203141 Rana catesbeiana 201 32-201 E153 H152, H156, H162 GENBANK:PIO28305
MER0004499 Rattus norvegicus 466 98-276 E219 H218, H222, H228 UNIPROT:O88766
MER0004499 Rattus norvegicus 466 98-276 E219 H218, H222, H228 UNIPROT:O88766
MER0004499 Rattus norvegicus 466 98-276 E219 H218, H222, H228 UNIPROT:O88766
MER1203125 Rattus norvegicus 398 100-277 E219 H218, H222, H228 GENBANK:XP_006242558
MER1203026 Rhinolophus sinicus 468 102-280 E221 H220, H224, H230 GENBANK:XP_019568235
MER1203106 Rhinopithecus bieti 468 99-278 E218 H217, H221, H227 GENBANK:XP_017705583
MER0558612 Rhinopithecus roxellana 467 97-275 E218 H217, H221, H227 GENBANK:XP_010377372
MER1203029 Rousettus aegyptiacus 468 102-279 E221 H220, H224, H230 GENBANK:XP_015989475
MER0329263 Saimiri boliviensis 465 99-277 E218 H217, H221, H227 GENBANK:XP_003923819
MER1203098 Saimiri boliviensis 442 76-254 E195 H194, H198, H204 GENBANK:XP_010332916
MER0549831 Serinus canaria 468 102-278 E221 H220, H224, H230 GENBANK:XP_009101028
MER1204072 Sinocyclocheilus grahami 398 39-209 E151 H150, H154, H160 GENBANK:XP_016125107
MER1203093 Sturnus vulgaris 468 101-280 E221 H220, H224, H230 GENBANK:XP_014742087
MER0290854 Sus scrofa 468 102-280 E221 H220, H224, H230 UNIPROT:F1SV69
MER0290854 Sus scrofa 468 102-280 E221 H220, H224, H230 UNIPROT:F1SV69
MER0161387 Taeniopygia guttata 466 100-274 E219 H218, H222, H228 GENBANK:XP_002198044
MER0034194 Tauraco erythrolophus 469 101-279 E222 H221, H225, H231 UNIPROT:A0A093CWS7
MER0034194 Tauraco erythrolophus 469 101-279 E222 H221, H225, H231 UNIPROT:A0A093CWS7
MER1203054 Trichechus manatus 380 14-191 E133 H132, H136, H142 GENBANK:XP_023595895
MER0190805 Tupaia chinensis 954 102-307 E248 H247, H251, H257 GENBANK:XP_006150152
MER1203016 Tursiops truncatus 468 102-279 E221 H220, H224, H230 GENBANK:XP_019804379
MER0086338 Ursus maritimus 475 108-286 E229 H228, H232, H238 GENBANK:XP_008688370
MER1203133 Vicugna pacos 296 40-211 E153 H152, H156, H162 GENBANK:XP_015096767
MER0036204 Xenopus laevis 259 89-259 E210 H209, H213, H219 UNIPROT:Q7SZT5
MER0036204 Xenopus laevis 259 89-259 E210 H209, H213, H219 UNIPROT:Q7SZT5
MER1203123 Xenopus tropicalis 232 71-232 E185 H184, H188, H194 GENBANK:XP_017947346
MER1205438 Xenopus tropicalis 99 1-99 E52 H51, H55, H61 GENBANK:OCA47134