Sequence features for peptidase M10.002: matrix metallopeptidase-8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0690174 Acanthisitta chloris 466 98-276 E219 H218, H222, H228 GENBANK:XP_009076258
MER1203084 Acanthisitta chloris 467 100-279 E220 H219, H223, H229 GENBANK:KFP70751
MER1203078 Acinonyx jubatus 476 110-287 E229 H228, H232, H238 GENBANK:XP_014929409
MER0290851 Ailuropoda melanoleuca 475 110-287 E229 H228, H232, H238 GENBANK:XP_002922069
MER0269521 Alligator mississippiensis 466 98-278 E219 H218, H222, H228 GENBANK:XP_006272556
MER1203095 Alligator mississippiensis 462 96-274 E215 H214, H218, H224 GENBANK:KYO44958
MER1203127 Alligator mississippiensis 381 13-192 E134 H133, H137, H143 GENBANK:KYO44959
MER1203157 Alligator mississippiensis 356 4-167 E109 H108, H112, H118 GENBANK:XP_019337495
MER1203420 Alligator mississippiensis 342 4-153 E95 H94, H98, H104 GENBANK:KYO44960
MER0296274 Alligator sinensis 466 98-278 E219 H218, H222, H228 GENBANK:XP_006038117
MER0290865 Anolis carolinensis 465 98-276 E218 H217, H221, H227 GENBANK:XP_003219341
MER1203120 Anser cygnoides 466 99-278 E219 H218, H222, H228 GENBANK:XP_013033641
MER1203059 Antrostomus carolinensis 467 100-279 E220 H219, H223, H229 GENBANK:KFZ52511
MER1203087 Aotus nancymaae 465 99-277 E218 H217, H221, H227 GENBANK:XP_012310575
MER0687582 Aptenodytes forsteri 466 98-276 E219 H218, H222, H228 GENBANK:XP_009272902
MER0686664 Aquila chrysaetos 466 98-276 E219 H218, H222, H228 GENBANK:XP_011594083
MER0403044 Balaenoptera acutorostrata 468 100-468 E221 H220, H224, H230 GENBANK:XP_007191286
MER0682225 Balearica regulorum 468 102-278 E221 H220, H224, H230 UNIPROT:A0A087VAS0
MER0682225 Balearica regulorum 468 102-278 E221 H220, H224, H230 UNIPROT:A0A087VAS0
MER1203066 Bambusicola thoracica 284 33-212 E153 H152, H156, H162 GENBANK:POI25069
MER0190774 Bos grunniens 470 102-279 E221 H220, H224, H230 GENBANK:ELR53688
MER0195766 Bos taurus 494 100-278 E221 H220, H224, H230 GENBANK:DAA22479
MER1205124 Branchiostoma belcheri 592 146-306 E261 H260, H264, H270 GENBANK:XP_019620911
MER1203140 Callipepla squamata 1457 1090-1269 E1210 H1209, H1213, H1219 GENBANK:OXB57866
MER0290856 Callithrix jacchus 465 97-277 E218 H217, H221, H227 UNIPROT:F7DGR3
MER0290856 Callithrix jacchus 465 97-277 E218 H217, H221, H227 UNIPROT:F7DGR3
MER1203134 Camelus bactrianus 470 102-279 E221 H220, H224, H230 GENBANK:XP_010951492
MER0676414 Camelus dromedarius 470 100-278 E221 H220, H224, H230 GENBANK:XP_010976091
MER0825125 Camelus ferus 751 105-262 E216, E460 H459, H215, H219, H463, H225, H469 UNIPROT:S9WV44
MER0825125 Camelus ferus 751 105-262 E216, E460 H459, H215, H219, H463, H225, H469 UNIPROT:S9WV44
MER1203130 Camelus ferus 402 34-211 E153 H152, H156, H162 GENBANK:XP_014415935
MER0053696 Canis lupus familiaris 476 108-287 E229 H228, H232, H238 UNIPROT:F1PVR0
MER0053696 Canis lupus familiaris 476 108-287 E229 H228, H232, H238 UNIPROT:F1PVR0
MER1203086 Castor canadensis 468 100-279 E221 H220, H224, H230 GENBANK:XP_020023669
MER0825146 Cathartes aura 468 110-272 E221 H220, H224, H230 UNIPROT:A0A091MFR7
MER0825146 Cathartes aura 468 110-272 E221 H220, H224, H230 UNIPROT:A0A091MFR7
MER1203058 Cebus capucinus 465 99-277 E218 H217, H221, H227 GENBANK:XP_017400262
MER1203108 Ceratotherium simum 474 100-283 E225 H224, H228, H234 GENBANK:XP_014640696
MER1203032 Cercocebus atys 476 108-286 E227 H226, H230, H236 GENBANK:XP_011921976
MER1203129 Colinus virginianus 770 99-278 E219 H218, H222, H228 GENBANK:OXB72006
MER0671445 Colius striatus 433 98-276 E219 H218, H222, H228 GENBANK:XP_010197938
MER0670301 Colobus angolensis 467 97-275 E218 H217, H221, H227 GENBANK:XP_011782020
MER0190769 Columba livia 433 66-245 E186 H185, H189, H195 GENBANK:EMC80516
MER0668331 Corvus cornix 400 34-210 E153 H152, H156, H162 GENBANK:XP_010398897
MER1203115 Coturnix japonica 466 99-278 E219 H218, H222, H228 GENBANK:XP_015707753
MER0290866 Cricetulus griseus 600 101-278 E220 H219, H223, H229 GENBANK:XP_003496193
MER0290896 Cricetulus griseus 966 746-851 E180, E554, E806 H553, H805, H179, H557, H809, H183, H189, H563, H815 UNIPROT:G3GUV4
MER0290896 Cricetulus griseus 966 746-851 E180, E554, E806 H553, H805, H179, H557, H809, H183, H189, H563, H815 UNIPROT:G3GUV4
MER1203110 Crocodylus porosus 466 100-277 E219 H218, H222, H228 GENBANK:XP_019385813
MER1203118 Crocodylus porosus 462 96-274 E215 H214, H218, H224 GENBANK:XP_019385815
MER0665125 Cuculus canorus 466 98-276 E219 H218, H222, H228 GENBANK:XP_009554379
MER1206519 Cyprinus carpio 119 22-118 E74, H73, H77, H83, GENBANK:KTF94833
MER1203015 Delphinapterus leucas 468 102-279 E221 H220, H224, H230 GENBANK:XP_022416256
MER1203105 Dipodomys ordii 453 88-265 E206 H205, H209, H215 GENBANK:XP_012865025
MER1203136 Echinops telfairi 471 104-282 E224 H223, H227, H233 GENBANK:XP_012861692
MER1203017 Enhydra lutris 467 102-279 E221 H220, H224, H230 GENBANK:XP_022368736
MER1203128 Equus asinus 501 133-312 E254 H253, H257, H263 GENBANK:XP_014715503
MER1204270 Equus asinus 447 133-241 missing missing, missing, missing GENBANK:XP_014715504
MER0098642 Equus caballus 471 100-280 E222 H221, H225, H231 GENBANK:XP_001498886
MER1203124 Equus caballus 411 41-220 E162 H161, H165, H171 GENBANK:XP_023500481
MER0329236 Felis catus 468 102-279 E221 H220, H224, H230 UNIPROT:M3WNA0
MER0329236 Felis catus 468 102-279 E221 H220, H224, H230 UNIPROT:M3WNA0
MER0656639 Fukomys damarensis 470 100-278 E221 H220, H224, H230 GENBANK:XP_010640353
MER0655127 Fulmarus glacialis 466 98-278 E219 H218, H222, H228 GENBANK:XP_009583185
MER0654032 Gavia stellata 466 98-276 E219 H218, H222, H228 GENBANK:XP_009808362
MER1203065 Gavialis gangeticus 400 34-212 E153 H152, H156, H162 GENBANK:XP_019381032
MER1203099 Gavialis gangeticus 466 100-277 E219 H218, H222, H228 GENBANK:XP_019381030
MER0329206 Gorilla gorilla 467 99-277 E218 H217, H221, H227 UNIPROT:G3R051
MER0329206 Gorilla gorilla 467 99-277 E218 H217, H221, H227 UNIPROT:G3R051
MER1203046 Gorilla gorilla 444 76-254 E195 H194, H198, H204 GENBANK:XP_018891525
MER0652878 Haliaeetus albicilla 466 98-276 E219 H218, H222, H228 GENBANK:XP_009911929
MER0651353 Haliaeetus leucocephalus 466 98-276 E219 H218, H222, H228 GENBANK:XP_010560425
MER0290853 Heterocephalus glaber 470 102-279 E221 H220, H224, H230 UNIPROT:G5BUC2
MER0290853 Heterocephalus glaber 470 102-279 E221 H220, H224, H230 UNIPROT:G5BUC2
MER1203062 Heterocephalus glaber 382 14-191 E133 H132, H136, H142 GENBANK:XP_021104687
MER1203019 Hipposideros armiger 470 102-281 E223 H222, H226, H232 GENBANK:XP_019487809
MER0001084 Homo sapiens 467 97-275 E218 H217, H221, H227 GENBANK:XP_011541136
MER0001084 Homo sapiens 467 97-275 E218 H217, H221, H227 GENBANK:XP_011541136
MER0001084 Homo sapiens 467 97-275 E218 H217, H221, H227 GENBANK:XP_011541136
MER0611721 Latimeria chalumnae 410 76-394 E187 H186, H190, H196 GENBANK:XP_005998667
MER0290870 Loxodonta africana 471 102-280 E221 H220, H224, H230 GENBANK:XP_003415714
MER0290852 Macaca fascicularis 467 99-277 E218 H217, H221, H227 UNIPROT:G7PNK2
MER0290852 Macaca fascicularis 467 99-277 E218 H217, H221, H227 UNIPROT:G7PNK2
MER1203048 Macaca fascicularis 476 108-286 E227 H226, H230, H236 GENBANK:XP_015291126
MER0112728 Macaca mulatta 467 97-275 E218 H217, H221, H227 GENBANK:XP_001098000
MER1203060 Macaca mulatta 476 108-286 E227 H226, H230, H236 GENBANK:XP_014971041
MER0647467 Manacus vitellinus 466 98-276 E219 H218, H222, H228 GENBANK:XP_008921010
MER0645614 Mandrillus leucophaeus 467 97-275 E218 H217, H221, H227 GENBANK:XP_011839790
MER1203023 Manis javanica 468 102-279 E221 H220, H224, H230 GENBANK:XP_017521714
MER1203121 Marmota marmota 469 102-278 E220 H219, H223, H229 GENBANK:XP_015345430
MER0290861 Meleagris gallopavo 466 99-278 E219 H218, H222, H228 GENBANK:XP_003203529
MER1203139 Meriones unguiculatus 467 101-278 E220 H219, H223, H229 GENBANK:XP_021484219
MER0012232 Mesocricetus auratus 68 1-68 E44 H43, H47, H53 UNIPROT:Q9JM43
MER0012232 Mesocricetus auratus 68 1-68 E44 H43, H47, H53 UNIPROT:Q9JM43
MER1203101 Miniopterus natalensis 467 100-279 E221 H220, H224, H230 GENBANK:XP_016062205
MER1203109 Mus caroli 466 100-278 E219 H218, H222, H228 GENBANK:XP_021027997
MER0004500 Mus musculus 465 97-275 E218 H217, H221, H227 UNIPROT:O70138
MER0004500 Mus musculus 465 97-275 E218 H217, H221, H227 UNIPROT:O70138
MER0004500 Mus musculus 465 97-275 E218 H217, H221, H227 UNIPROT:O70138
MER1203100 Mus pahari 468 102-280 E221 H220, H224, H230 GENBANK:XP_021061921
MER0290850 Mustela putorius 247 33-210 E152 H151, H155, H161 UNIPROT:G9KAY1
MER0290850 Mustela putorius 247 33-210 E152 H151, H155, H161 UNIPROT:G9KAY1
MER1203014 Mustela putorius 472 107-284 E226 H225, H229, H235 GENBANK:XP_012917886
MER1203042 Myotis brandtii 400 33-211 E153 H152, H156, H162 GENBANK:XP_014400075
MER1203070 Myotis davidii 485 101-279 E221 H220, H224, H230 GENBANK:XP_015426929
MER1203051 Myotis lucifugus 465 98-276 E218 H217, H221, H227 GENBANK:XP_023614610
MER0614111 Nannospalax galili 469 99-277 E220 H219, H223, H229 GENBANK:XP_008828293
MER1203076 Neomonachus schauinslandi 477 111-288 E230 H229, H233, H239 GENBANK:XP_021552027
MER1203145 Neotoma lepida 948 101-278 E220 H219, H223, H229 GENBANK:OBS70043
MER0825092 Neovison vison 265 71-230 E182 H181, H185, H191 UNIPROT:U6DJE4
MER0825092 Neovison vison 265 71-230 E182 H181, H185, H191 UNIPROT:U6DJE4
MER0257633 Nomascus leucogenys 517 147-327 E268 H267, H271, H277 GENBANK:XP_003253514
MER0634762 Notothenia coriiceps 164 9-154 E110 H109, H113, H119 GENBANK:XP_010765237
MER1203097 Numida meleagris 467 100-279 E220 H219, H223, H229 GENBANK:XP_021236581
MER1203075 Odocoileus virginianus 470 102-279 E221 H220, H224, H230 GENBANK:XP_020739074
MER1204252 Odocoileus virginianus 414 100-205 missing missing, missing, missing GENBANK:XP_020739073
MER0825022 Ophiophagus hannah 404 109-270 E221 H220, H224, H230 UNIPROT:V8NUV1
MER0825022 Ophiophagus hannah 404 109-270 E221 H220, H224, H230 UNIPROT:V8NUV1
MER0097788 Ornithorhynchus anatinus 629 97-274 E216, E470 H215, H469, H219, H473, H225, H479 GENBANK:XP_001509994
MER0097789 Ornithorhynchus anatinus 629 458-527 E216, E470 H215, H469, H219, H473, H225, H479 GENBANK:XP_001509994
MER0826608 Ornithorhynchus anatinus 573 58-374 E322 H321, H325, H331 UNIPROT:F7B2W9
MER0290883 Oryctolagus cuniculus 408 49-219 E161 H160, H164, H170 GENBANK:XP_002708467
MER0256232 Otolemur garnettii 465 97-277 E218 H217, H221, H227 UNIPROT:H0XCW8
MER0256232 Otolemur garnettii 465 97-277 E218 H217, H221, H227 UNIPROT:H0XCW8
MER1203142 Ovis ammon musimon 470 102-269 E221 H220, H224, H230 GENBANK:XP_012008196
MER0329254 Ovis aries 470 102-279 E221 H220, H224, H230 GENBANK:XP_004016575
MER0341941 Pan paniscus 467 99-277 E218 H217, H221, H227 GENBANK:XP_003828427
MER1203034 Pan troglodytes 444 76-254 E195 H194, H198, H204 GENBANK:XP_016777366
MER1203090 Panthera pardus 476 110-287 E229 H228, H232, H238 GENBANK:XP_019289237
MER0329101 Papio anubis 467 99-277 E218 H217, H221, H227 UNIPROT:A0A096NQR7
MER0329101 Papio anubis 467 99-277 E218 H217, H221, H227 UNIPROT:A0A096NQR7
MER1203020 Papio anubis 476 108-286 E227 H226, H230, H236 GENBANK:XP_009185434
MER1203823 Paramormyrops kingsleyae 498 131-308 E246 H245, H249, H255 GENBANK:XP_023700747
MER1203068 Patagioenas fasciata 465 98-277 E218 H217, H221, H227 GENBANK:OPJ68645
MER1203111 Peromyscus maniculatus 469 101-278 E220 H219, H223, H229 GENBANK:XP_006983830
MER0632257 Phaethon lepturus 465 97-275 E218 H217, H221, H227 GENBANK:XP_010280672
MER0631651 Phalacrocorax carbo 466 98-276 E219 H218, H222, H228 GENBANK:XP_009512512
MER1203043 Phalacrocorax carbo 467 100-279 E220 H219, H223, H229 GENBANK:KFW95931
MER1203080 Phascolarctos cinereus 468 99-277 E219 H218, H222, H228 GENBANK:XP_020851846
MER0629460 Picoides pubescens 466 98-278 E219 H218, H222, H228 GENBANK:XP_009894707
MER1203082 Piliocolobus tephrosceles 467 99-277 E218 H217, H221, H227 GENBANK:XP_023063898
MER0341944 Pongo abelii 465 98-277 E218 H217, H221, H227 GENBANK:XP_003777917
MER1203025 Pongo abelii 467 98-277 E218 H217, H221, H227 GENBANK:XP_024111234
MER1203077 Propithecus coquereli 465 98-277 E218 H217, H221, H227 GENBANK:XP_012514613
MER1203132 Protobothrops mucrosquamatus 973 101-280 E221 H220, H224, H230 GENBANK:XP_015670206
MER0553740 Pterocles gutturalis 465 97-275 E218 H217, H221, H227 UNIPROT:A0A093DMB1
MER0553740 Pterocles gutturalis 465 97-275 E218 H217, H221, H227 UNIPROT:A0A093DMB1
MER1203757 Pygocentrus nattereri 490 121-290 E232 H231, H235, H241 GENBANK:XP_017563172
MER0824928 Pygoscelis adeliae 467 108-271 E220 H219, H223, H229 UNIPROT:A0A093R4E1
MER0824928 Pygoscelis adeliae 467 108-271 E220 H219, H223, H229 UNIPROT:A0A093R4E1
MER1203141 Rana catesbeiana 201 32-201 E153 H152, H156, H162 GENBANK:PIO28305
MER0004499 Rattus norvegicus 466 98-276 E219 H218, H222, H228 UNIPROT:O88766
MER0004499 Rattus norvegicus 466 98-276 E219 H218, H222, H228 UNIPROT:O88766
MER0004499 Rattus norvegicus 466 98-276 E219 H218, H222, H228 UNIPROT:O88766
MER1203125 Rattus norvegicus 398 100-277 E219 H218, H222, H228 GENBANK:XP_006242558
MER1203026 Rhinolophus sinicus 468 102-280 E221 H220, H224, H230 GENBANK:XP_019568235
MER1203106 Rhinopithecus bieti 468 99-278 E218 H217, H221, H227 GENBANK:XP_017705583
MER0558612 Rhinopithecus roxellana 467 97-275 E218 H217, H221, H227 GENBANK:XP_010377372
MER1203029 Rousettus aegyptiacus 468 102-279 E221 H220, H224, H230 GENBANK:XP_015989475
MER0329263 Saimiri boliviensis 465 99-277 E218 H217, H221, H227 GENBANK:XP_003923819
MER1203098 Saimiri boliviensis 442 76-254 E195 H194, H198, H204 GENBANK:XP_010332916
MER0549831 Serinus canaria 468 102-278 E221 H220, H224, H230 GENBANK:XP_009101028
MER1204072 Sinocyclocheilus grahami 398 39-209 E151 H150, H154, H160 GENBANK:XP_016125107
MER1203093 Sturnus vulgaris 468 101-280 E221 H220, H224, H230 GENBANK:XP_014742087
MER0290854 Sus scrofa 468 102-280 E221 H220, H224, H230 UNIPROT:F1SV69
MER0290854 Sus scrofa 468 102-280 E221 H220, H224, H230 UNIPROT:F1SV69
MER0161387 Taeniopygia guttata 466 100-274 E219 H218, H222, H228 GENBANK:XP_002198044
MER0034194 Tauraco erythrolophus 469 101-279 E222 H221, H225, H231 UNIPROT:A0A093CWS7
MER0034194 Tauraco erythrolophus 469 101-279 E222 H221, H225, H231 UNIPROT:A0A093CWS7
MER1203054 Trichechus manatus 380 14-191 E133 H132, H136, H142 GENBANK:XP_023595895
MER0190805 Tupaia chinensis 954 102-307 E248 H247, H251, H257 GENBANK:XP_006150152
MER1203016 Tursiops truncatus 468 102-279 E221 H220, H224, H230 GENBANK:XP_019804379
MER0086338 Ursus maritimus 475 108-286 E229 H228, H232, H238 GENBANK:XP_008688370
MER1203133 Vicugna pacos 296 40-211 E153 H152, H156, H162 GENBANK:XP_015096767
MER0036204 Xenopus laevis 259 89-259 E210 H209, H213, H219 UNIPROT:Q7SZT5
MER0036204 Xenopus laevis 259 89-259 E210 H209, H213, H219 UNIPROT:Q7SZT5
MER1203123 Xenopus tropicalis 232 71-232 E185 H184, H188, H194 GENBANK:XP_017947346
MER1205438 Xenopus tropicalis 99 1-99 E52 H51, H55, H61 GENBANK:OCA47134