$VAR1 = undef;

Summary for peptidase M10.001: matrix metallopeptidase-1

Names
MEROPS Name	matrix metallopeptidase-1
Other names	collagenase 1, interstitial collagenase, matrix metalloproteinase 1, MMP-1, vertebrate collagenase

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.001
Holotype	matrix metallopeptidase-1 (Homo sapiens), Uniprot accession P03956 (peptidase unit: 98-276), MERNUM MER0001063
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00154
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.7
Enzymology	BRENDA database
Proteolytic events	CutDB database (31 cleavages)
Physiology	Role in turnover of most types of collagen.
Pharmaceutical relevance	Drug target for prevention of pathological tissue damage. IgG autoantibodies in sera from systemic sclerosis patients inhibited the enzyme, and may have contributed to fibrosis (Sato et al., 2003).
Pathways	KEGG	Bladder cancer
	KEGG	Pathways in cancer
	KEGG	PPAR signaling pathway
	KEGG	Rheumatoid arthritis
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP1
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/pa/-/-li/-/-/- (based on 91 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	13	5	3	20	0	4	14	6
Pro	3	30	3	3	2	1	2	8
Ala	13	22	10	20	7	8	14	10
Val	3	6	6	6	10	11	9	8
Leu	10	7	15	4	27	7	4	4
Ile	2	3	2	0	15	3	2	5
Met	1	1	1	1	6	3	1	1
Phe	4	0	1	4	5	3	0	2
Tyr	1	2	2	4	0	3	2	0
Trp	0	0	0	0	0	1	0	0
Ser	3	4	6	3	4	9	11	10
Thr	7	0	2	1	2	4	7	7
Cys	0	0	0	1	0	0	0	2
Asn	0	0	4	4	0	3	3	1
Gln	6	2	14	3	4	3	4	10
Asp	4	2	2	4	2	1	1	2
Glu	8	1	10	1	1	4	8	4
Lys	1	2	4	4	0	8	3	3
Arg	4	3	4	5	1	11	3	5
His	2	1	0	3	1	2	2	0

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
MMP1	11q22-q23		ENSG00000149968	4312	MMP1	120353