Structure for peptidase M10.001: matrix metallopeptidase-1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1FBL	Sus scrofa	2.50 Å	mature
The catalytic and structural zinc ions are shown as light grey CPK spheres. The structural calcium ions are shown as yellow CPK spheres. The zinc ligands are shown in ball-and-stick representation: His218, His222 and His228 in purple. The catalytic Glu219 is shown in blue. Bound inhibitor is shown in grey in ball-and-stick representation.

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2TCL	Homo sapiens	2.20 Å	catalytic domain; complex with [[1-[N-hydroxy-acetamidyl]-3-methyl-butyl]-carbonyl-leucinyl]-alanine ethyl ester
The structural and catalytic zinc ions are shown as light grey CPK spheres. The structural calcium ions are shown as yellow CPK spheres. The zinc ligands are shown in ball-and-stick representation: His218, His222 and His228 in purple. The catalytic Glu219 is shown in blue in ball-and-stick representation. The RO 31-4724 synthetic inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
NMR structure of catalytic domain	0.00 Å	1AYK	1AYK	1AYK	1AYK	1AYK	1AYK	Moy et al., 1998
complex with stromelysin and PG-117025 inhibitor	2.30 Å	1BQO	1BQO	1BQO	1BQO	1BQO	1BQO	Pikul et al., 1998
recombinant peptidase domain	1.90 Å	1CGE	1CGE	1CGE	1CGE	1CGE	1CGE	Lovejoy et al., 1994
catalytic domain binary complex	2.10 Å	1CGF	1CGF	1CGF	1CGF	1CGF	1CGF	Lovejoy et al., 1994
recombinant catalytic domain	2.40 Å	1CGL	1CGL	1CGL	1CGL	1CGL	1CGL	Lovejoy et al., 1994
recombinant	1.56 Å	1HFC	1HFC	1HFC	1HFC	1HFC	1HFC	Spurlino et al., 1994
precursor	2.20 Å	1SU3	1SU3	1SU3	1SU3	1SU3	1SU3	Jozic et al., 2005
catalytic domain; complex with inhibitor	2.20 Å	1TCL	1TCL	1TCL	1TCL	1TCL	1TCL
NMR structure; inhibitor-free catalytic domain	0.00 Å	2AYK	2AYK	2AYK	2AYK	2AYK	2AYK	Moy et al., 1998
active form	2.67 Å	2CLT	2CLT	2CLT	2CLT	2CLT	2CLT	Iyer et al., 2006
catalytic domain; complex with the inhibitory domain of TIMP-1	2.54 Å	2J0T	2J0T	2J0T	2J0T	2J0T	2J0T	Iyer et al., 2007
catalytic domain; complex with [[1-[N-hydroxy-acetamidyl]-3-methyl-butyl]-carbonyl-leucinyl]-alanine ethyl ester	2.20 Å	2TCL	2TCL	2TCL	2TCL	2TCL	2TCL	Borkakoti et al., 1994
NMR structure; catalytic domain; complex with CGS-27023A inhibitor	0.00 Å	3AYK	3AYK	3AYK	3AYK	3AYK	3AYK	Moy et al., 1999
mature peptidase	2.20 Å	3SHI	3SHI	3SHI	3SHI	3SHI	3SHI	Bertini et al., 2012
mature peptidase	3.00 Å	4AUO	4AUO	4AUO	4AUO	4AUO	4AUO	Manka et al., 2012
NMR structure; catalytic domain; complex with CGS-27023A inhibitor	0.00 Å	4AYK	4AYK	4AYK	4AYK	4AYK	4AYK	Moy et al., 1999
catalytic domain; complex with N-hydroxy-2-[4-(4-phenoxy-benzenesulfonyl)-tetrahydro-pyran-4-yl]-acetamide	1.90 Å	966C	966C	966C	966C	966C	966C	Lovejoy et al., 1999
Sus scrofa
mature peptidase	2.50 Å	1FBL	1FBL	1FBL	1FBL	1FBL	1FBL	Li et al., 1995