$VAR1 = undef;
Summary for peptidase M01.001: aminopeptidase N
| Names | |
|---|---|
| MEROPS Name | aminopeptidase N |
| Other names | alanine aminopeptidase, alanyl-aminopeptidase, amino-oligopeptidase, ANPEP g.p. (Homo sapiens), AOP, aminopeptidase M, CD13, membrane Cys-Gly dipeptidase, membrane aminopeptidase I, membrane alanyl aminopeptidase (eukaryote), microsomal aminopeptidase, neutral aminopeptidase, particle-bound aminopeptidase, peptidase E, pseudo leucine aminopeptidase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.001 |
| Holotype | aminopeptidase N (Homo sapiens), Uniprot accession P15144 (peptidase unit: 301-517), MERNUM MER0000997 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00123 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.2 | ||
| Enzymology | BRENDA database | ||
| Activity status | human: active (Turner, 2004) mouse: active (Matthews et al., 2001) | ||
| Physiology | Ectoenzyme inactivating enkephalins (Le Guen et al., 2003) and other bioactive peptides. A receptor for coronavirus infection (Wentworth et al., 2001). | ||
| Knockout | Dogs showing specific deficiency of brush border aminopeptidase N in the small intestines were clinically healthy, and the deficiency was attributed to diminished expression of an otherwise normal enzyme protein (Pemberton et al., 1997). | ||
| Pharmaceutical relevance | Degrades bioactive peptides including enkephalins, and hence a drug target for analgesia (Bernkop-Schnurch & Marschutz, 1997). Serum level greatly increased in cholestasis (Janas et al., 2002). In inflammation, induces chemotactic migration of T lymphocytes by its enzymatic activity (Shimizu et al., 2002). | ||
| Pathways | KEGG | Glutathione metabolism | |
| KEGG | Hematopoietic cell lineage | ||
| KEGG | Renin-angiotensin system | ||
| Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/Alanine_aminopeptidase | |
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | -/-/-/- wgf/y/fi/- (based on 42 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| ANPEP | 15q25-q26 | ENSG00000166825 | 290 | ANPEP | 151530 | |
