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Literature for peptidase M01.001: aminopeptidase N

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Wen,D.K., Fan,L., Zhou,J.L. and Wang,K.
    An activatable Hemicyanine-based fluorescent probe for specific detection and imaging of aminopeptidase N in diabetic wound healing
    Spectrochim Acta A Mol Biomol Spectrosc (2026) 345, 126848-126848. PubMed  Europe PubMed DOI
    2. 2025
  2. An,D., Li,Y., Pei,Y., Ma,Y.H., Yao,F., Feng,Y., Shan,Y. and Liu,F.
    Resolving the APN controversy in PEDV infection: Comparative kinetic characterization through single-virus tracking
    PLoS Pathog (2025) 21, e1013317-e1013317. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Farsa,O. and Uher,T.
    Aminopeptidase N: a multifunctional and promising target in medicinal chemistry
    RSC Adv (2025) 15, 26455-26472. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Jin,M., Jefferson,V.A., Zhao,Z., Catanzaro,N.J., De Sabato,L., Keller,E.L., Menasche,B.L., Hoffman,C., Castelli,A., Di Bartolo,I., Vaccari,G., Starr,T.N., Seifert,S.N., Castellanos,A.A., Han,B.A., Serebryannyy,L., Spaulding,A.B., Douek,D.C., Moreno,A., Baric,R.S., Wilen,C.B., Rini,J.M. and Letko,M.
    Aminopeptidase N is a receptor for hedgehog merbecoviruses
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  5. Lean,F.Z.X., Gallo,G., Newman,J., Ackroyd,S., Spiro,S., Cox,R., Nymo,I.H., Brojer,C., Neimanis,A., Suarez-Bonnet,A., Priestnall,S.L., Everest,H., Keep,S., Bailey,D., Delahay,R.J., Seekings,A.H., McElhinney,L.M., Brookes,S.M. and Nunez,A.
    Distribution of aminopeptidase N coronavirus receptors in the respiratory and digestive tracts of domestic and wild artiodactyls and carnivores
    J Gen Virol (2025) 106 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Muraoka,S., Brodie,W.D., Mattichak,M.N., Gurrea-Rubio,M., Ikari,Y., Foster,C., Amin,M.A., Khanna,N., Amin,H., Campbell,P.L., Vichaikul,S., Model,E.N., Omara,M.M., Petrovski,S., Kozicki,K., Amarista,C., Webber,A., Ali,M., Palisoc,P.J., Hervoso,J., Ruth,J.H., Tsoi,L.C., Varga,J., Gudjonsson,J.E., Khanna,D., Fox,D.A. and Tsou,P.S.
    Targeting CD13/aminopeptidase N as a novel therapeutic approach for scleroderma fibrosis
    Arthritis Rheumatol (2025) 77, 80-91. PubMed  Europe PubMed DOI
  7. Sun,X., Wang,X., Fu,L., Wang,X., Chen,L. and Huang,Y.
    Correction to "A Nanofluorescent Probe for Evaluating the Fluctuation of Aminopeptidase N in Nonalcoholic Fatty Liver Disease and Hepatic Fibrosis"
    Anal Chem (2025) PubMed  Europe PubMed DOI
  8. Tsai,Y.X., Chien,Y.C., Hsu,M.F., Khoo,K.H. and Hsu,S.D.
    Molecular basis of host recognition of human coronavirus 229E
    Nat Commun (2025) 16, 2045-2045. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Yi,B., Yatabe,H., Sakamoto,D.M., Tamura,I., Saito,Y., Yamada,N., Ashikaga,R., Kuroda,M., Kubota,S.I., Tainaka,K. and Sando,S.
    Imaging Heterogeneous Patterns of Aminopeptidase N Activity in Hierarchical Tissue Structures Through High-resolution Whole-organ 3D Mapping
    Angew Chem Int Ed Engl (2025) , e202504668-e202504668. PubMed  Europe PubMed DOI
  10. Zhang,Y.Q., Wang,B., Yang,Y.L., Meng,J.X., Zhang,M.D., Li,Y.K., Dong,B., Zhang,Y., Liu,B.W., Yang,D., Ji,C.M., Huang,Y.W. and Zhu,S.J.
    A gut microbiota-bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N
    Imeta (2025) 4, e70061-e70061. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2024
  11. Anderluzzi,G., Ghitti,M., Gasparri,A.M., Taie,G., Sacchi,A., Gori,A., Andolfo,A., Pozzi,F., Musco,G., Curnis,F. and Corti,A.
    A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins
    Cell Mol Life Sci (2024) 81, 68-68. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Liang,W., Feng,R., Li,X., Duan,X., Feng,S., Chen,J., Li,Y., Chen,J., Liu,Z., Wang,X., Ruan,G., Tang,S., Ding,C., Huang,B., Zou,Z. and Chen,T.
    A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression
    Nat Commun (2024) 15, 8792-8792. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2023
  13. Diaz-Alvarez,L., Martinez-Sanchez,M.E., Gray,E., Perez-Figueroa,E. and Ortega,E.
    Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18
    Biomolecules (2023) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  14. Jia,G., Qi,K., Hou,B., Yue,K., Xu,T., Jiang,Y. and Li,X.
    Design, synthesis, and biological evaluation of novel HDAC/CD13 dual inhibitors for the treatment of cancer
    Eur J Med Chem (2023) 260, 115752-115752. PubMed  Europe PubMed DOI  I
  15. Lie,L.K., Synowiec,A., Mazur,J., Rabalski,L. and Pyrc,K.
    An engineered A549 cell line expressing CD13 and TMPRSS2 is permissive to clinical isolate of human coronavirus 229E
    Virology (2023) 588, 109889-109889. PubMed  Europe PubMed DOI
  16. Liu,Y., Chen,D., Wang,Y., Li,X., Qiu,Y., Zheng,M., Song,Y., Li,G., Song,C., Liu,T., Zhang,Y., Guo,J.T., Lin,H. and Zhao,X.
    Characterization of CCoV-HuPn-2018 spike protein-mediated viral entry
    J Virol (2023) 97, e0060123-e0060123. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2022
  17. Farsa,O., Ballayova,V., Zackova,R., Kollar,P., Kauerova,T. and Zubac,P.
    Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  18. Liu,Y., Zhao,D., Zhang,C., Fang,H., Shen,Q., Wang,Z. and Cao,J.
    Development of Hydroxamate Derivatives Containing a Pyrazoline Moiety as APN Inhibitors to Overcome Angiogenesis
    Molecules (2022) 27 PubMed  Europe PubMed DOI  PMC  EPMC  I
  19. Saito,Y., Yatabe,H., Tamura,I., Kondo,Y., Ishida,R., Seki,T., Hiraga,K., Eguchi,A., Takakusagi,Y., Saito,K., Oshima,N., Ishikita,H., Yamamoto,K., Krishna,M.C. and Sando,S.
    Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo
    Sci Adv (2022) 8, eabj2667-eabj2667. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Shatizadeh Malekshahi,S., Yavarian,J. and Shafiei-Jandaghi,N.Z.
    Usage of peptidases by SARS-CoV-2 and several human coronaviruses as receptors: A mysterious story
    Biotechnol Appl Biochem (2022) 69, 124-128. PubMed  Europe PubMed DOI
    21. 2021
  21. Barnieh,F.M., Loadman,P.M. and Falconer,R.A.
    Is tumour-expressed aminopeptidase N (APN/CD13) structurally and functionally unique?
    Biochim Biophys Acta Rev Cancer (2021) 1876, 188641-188641. PubMed  Europe PubMed DOI
  22. Gao,M., Lv,Q.L., Zhang,H.P. and Tu,G.G.
    Synthesis and 4D-QSAR studies of alanine hydroxamic acid derivatives as aminopeptidase N inhibitors
    Med Chem (2021) 17, 658-666. PubMed  Europe PubMed DOI  I
  23. Kis,A., Denes,N., Szabo,J.P., Arato,V., Beke,L., Matolay,O., Enyedi,K.N., Mehes,G., Mezo,G., Bai,P., Kertesz,I. and Trencsenyi,G.
    In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using (68)Ga-NODAGA-c(NGR) Peptide
    Biomed Res Int (2021) 2021, 6642973-6642973. PubMed  Europe PubMed DOI  PMC  EPMC  I
  24. Liu,Y., Xu,C., Liu,H.W., Teng,L., Huan,S., Yuan,L. and Zhang,X.B.
    Precipitated Fluorophore-Based Molecular Probe for In Situ Imaging of Aminopeptidase N in Living Cells and Tumors
    Anal Chem (2021) 93, 6463-6471. PubMed  Europe PubMed DOI
  25. Wang,L.T., Rajah,A., Brown,C.M. and McCaffrey,L.
    CD13 orients the apical-basal polarity axis necessary for lumen formation
    Nat Commun (2021) 12, 4697-4697. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Yang,Y.L., Liu,J., Wang,T.Y., Chen,M., Wang,G., Yang,Y.B., Geng,X., Sun,M.X., Meng,F., Tang,Y.D. and Feng,L.
    Aminopeptidase N is an entry co-factor triggering porcine deltacoronavirus entry via an endocytotic pathway
    J Virol (2021) , JVI0094421-JVI0094421. PubMed  Europe PubMed DOI
  27. Yoshihara,M., Mizutani,S., Kato,Y., Matsumoto,K., Mizutani,E., Mizutani,H., Fujimoto,H., Osuka,S. and Kajiyama,H.
    Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2020
  28. Asiabi,P., Dolmans,M.M., Ambroise,J., Camboni,A. and Amorim,C.A.
    In vitro differentiation of theca cells from ovarian cells isolated from postmenopausal women
    Hum Reprod (2020) 35, 2793-2807. PubMed  Europe PubMed DOI
  29. Balamurugan,T.S.T., Chen,G.Z., Kumaravel,S., Lin,C.M., Huang,S.T., Lee,Y.C., Chen,C.H. and Luo,G.R.
    Electrochemical substrate for active profiling of cellular surface leucine aminopeptidase activity and drug resistance in cancer cells
    Biosens Bioelectron (2020) 150, 111948-111948. PubMed  Europe PubMed DOI  A  L
  30. Banerjee,S., Amin,S.A., Baidya,S.K., Adhikari,N. and Jha,T.
    Exploring the structural aspects of ureido-amino acid-based APN inhibitors: a validated comparative multi-QSAR modelling study
    SAR QSAR Environ Res (2020) 31, 325-345. PubMed  Europe PubMed DOI  I
  31. Byrgazov,K., Anderson,C., Salzer,B., Bozsaky,E., Larsson,R., Gullbo,J., Lehner,M., Lehmann,F., Slipicevic,A., Kager,L., Fryknas,M. and Taschner-Mandl,S.
    Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
    Ther Adv Med Oncol (2020) 12, 1758835920937891-1758835920937891. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Cao,J., Zhao,W., Zhao,C., Liu,Q., Li,S., Zhang,G., Chou,C.J. and Zhang,Y.
    Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC
    Molecules (2020) 25 PubMed  Europe PubMed DOI  PMC  EPMC  I
  33. Cheng,Y.C., Ku,W.C., Tseng,T.T., Wu,C.P., Li,M. and Lee,S.C.
    Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin beta4 axis
    Aging (Albany NY) (2020) 12 PubMed  Europe PubMed DOI
  34. Devarakonda,C.K.V., Meredith,E., Ghosh,M. and Shapiro,L.H.
    Coronavirus Receptors as Immune Modulators
    J Immunol (2020) PubMed  Europe PubMed DOI  V
  35. Dominguez-Vias,G., Aretxaga,G., Prieto,I., Segarra,A.B., Luna,J.D., Martinez-Canamero,M. and Ramirez-Sanchez,M.
    Asymmetrical influence of a standard light/dark cycle and constant light conditions on the alanyl-aminopeptidase activity of the left and right retinas in adult male rats
    Exp Eye Res (2020) , 108149-108149. PubMed  Europe PubMed DOI
  36. Ge,J., Wang,Z., Cheng,Y., Ren,J., Wu,B., Li,W., Wang,X., Su,X. and Liu,Z.
    Computational study of novel natural inhibitors targeting aminopeptidase N (CD13)
    Aging (Albany NY) (2020) 12, 8523-8535. PubMed  Europe PubMed DOI  I
  37. Gregoriou,G.C., Patel,S.D., Winters,B.L. and Bagley,E.E.
    Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala
    Mol Pharmacol (2020) PubMed  Europe PubMed DOI  I
  38. Guo,Y., Carballar-Lejarazu,R., Sheng,L., Fang,Y., Wang,S., Liang,G., Hu,X., Wang,R., Zhang,F. and Wu,S.
    Identification and Characterization of Aminopeptidase-N as a Binding Protein for Cry3Aa in the Midgut of Monochamus alternatus (Coleoptera: Cerambycidae)
    J Econ Entomol (2020) PubMed  Europe PubMed DOI
  39. Kiehstaller,S., Ottmann,C. and Hennig,S.
    MMP activation associated Aminopeptidase N reveals a bivalent 14-3-3 binding motif
    J Biol Chem (2020) PubMed  Europe PubMed DOI
  40. Li,H., Yao,Q., Sun,W., Shao,K., Lu,Y., Chung,J., Kim,D., Fan,J., Long,S., Du,J., Li,Y., Wang,J., Yoon,J. and Peng,X.
    Aminopeptidase N activatable fluorescent probe for tracking metastatic cancer and image-guided surgery via in situ spraying
    J Am Chem Soc (2020) 142, 6381-6389. PubMed  Europe PubMed DOI  L
  41. Melo,F.J., Pinto-Lopes,P., Estevinho,M.M. and Magro,F.
    The Role of Dipeptidyl Peptidase 4 as a Therapeutic Target and Serum Biomarker in Inflammatory Bowel Disease: A Systematic Review
    Inflamm Bowel Dis (2020) PubMed  Europe PubMed DOI  V
  42. Peng,J.Y., Punyadarsaniya,D., Shin,D.L., Pavasutthipaisit,S., Beineke,A., Li,G., Wu,N.H. and Herrler,G.
    The Cell Tropism of Porcine Respiratory Coronavirus for Airway Epithelial Cells Is Determined by the Expression of Porcine Aminopeptidase N
    Viruses (2020) 12 PubMed  Europe PubMed DOI
  43. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.
    Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas
    Brain Res Bull (2020) 168, 1-7. PubMed  Europe PubMed DOI
  44. Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E.
    Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
    Bone Joint Res (2020) 9, 789-797. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2019
  45. Cao,J., Zang,J., Kong,X., Zhao,C., Chen,T., Ran,Y., Dong,H., Xu,W. and Zhang,Y.
    Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II
    Bioorg Med Chem (2019) 27, 978-990. PubMed  Europe PubMed DOI  I
  46. Chai,Y., Gao,Y., Xiong,H., Lv,W., Yang,G., Lu,C., Nie,J., Ma,C., Chen,Z., Ren,J. and Wang,F.
    A near-infrared fluorescent probe for monitoring leucine aminopeptidase in living cells
    Analyst (2019) 144, 463-467. PubMed  Europe PubMed DOI  L
  47. Chen,J., Pan,K., Chen,Z., Li,Y., Ding,B., Han,C., Cao,Z., Bao,W. and Zhang,Y.
    Production of porcine aminopeptidase N (pAPN) site-specific edited pigs
    Anim Sci J (2019) 90, 366-371. PubMed  Europe PubMed DOI  K
  48. Lee,J., Vinh,N.B., Drinkwater,N., Yang,W., Kannan Sivaraman,K., Schembri,L.S., Gazdik,M., Grin,P.M., Butler,G.S., Overall,C.M., Charman,S.A., McGowan,S. and Scammells,P.J.
    Novel human aminopeptidase N inhibitors: discovery and optimization of subsite binding interactions
    J Med Chem (2019) 62, 7185-7209. PubMed  Europe PubMed DOI  I
  49. Li,H., Li,Y., Yao,Q., Fan,J., Sun,W., Long,S., Shao,K., Du,J., Wang,J. and Peng,X.
    In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe
    Chem Sci (2019) 10, 1619-1625. PubMed  Europe PubMed DOI  PMC  EPMC  L
  50. Liu,H., Wang,X., Yang,H., Zhao,Y., Ji,S., Ma,H., Zhou,Y., Wang,Y., Zhang,H., Jiang,W., Fang,C., Feng,L. and Wang,X.
    New method for detecting the suppressing effect of enzyme activity by aminopeptidase N inhibitor
    Chem Pharm Bull (Tokyo) (2019) 67, 155-158. PubMed  Europe PubMed DOI  I
  51. Nganje,C.N., Haynes,S.A., Qabar,C.M., Lent,R.C., Bou Ghanem,E.N. and Shainheit,M.G.
    PepN is a non-essential, cell wall-localized protein that contributes to neutrophil elastase-mediated killing of Streptococcus pneumoniae
    PLoS ONE (2019) 14, e0211632-e0211632. PubMed  Europe PubMed DOI
  52. Wanat,W., Talma,M., Pawelczak,M. and Kafarski,P.
    Phosphonic acid analogues of phenylglycine as inhibitors of aminopeptidases: comparison of porcine aminopeptidase N, bovine leucine aminopeptidase, tomato acidic leucine aminopeptidase and aminopeptidase from barley seeds
    Pharmaceuticals (Basel) (2019) 12, 139-139. PubMed  Europe PubMed DOI  I
  53. Whitworth,K.M., Rowland,R.R.R., Petrovan,V., Sheahan,M., Cino-Ozuna,A.G., Fang,Y., Hesse,R., Mileham,A., Samuel,M.S., Wells,K.D. and Prather,R.S.
    Resistance to coronavirus infection in amino peptidase N-deficient pigs
    Transgenic Res (2019) 28, 21-32. PubMed  Europe PubMed DOI  K
  54. Zhang,J., Wu,Z. and Yang,H.
    Aminopeptidase N knockout pigs are not resistant to porcine epidemic diarrhea virus infection
    Virol Sin (2019) 34, 592-595. PubMed  Europe PubMed DOI  K
    55. 2018
  55. Amin,S.A., Adhikari,N. and Jha,T.
    Design of aminopeptidase N inhibitors as anti-cancer agents
    J Med Chem (2018) 61, 6468-6490. PubMed  Europe PubMed DOI  I
  56. Cao,J., Zang,J., Ma,C., Li,X., Hou,J., Li,J., Huang,Y., Xu,W., Wang,B. and Zhang,Y.
    Design, synthesis, and biological evaluation of pyrazoline-based hydroxamic acid derivatives as aminopeptidase N (APN) inhibitors
    ChemMedChem (2018) 13, 431-436. PubMed  Europe PubMed DOI  I
  57. Cao,J., Ma,C., Zang,J., Gao,S., Gao,Q., Kong,X., Yan,Y., Liang,X., Ding,Q., Zhao,C., Wang,B., Xu,W. and Zhang,Y.
    Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry
    Bioorg Med Chem (2018) 26, 3145-3157. PubMed  Europe PubMed DOI  I
  58. Huang,S., Wu,Y., Zeng,F., Chen,J. and Wu,S.
    A turn-on fluorescence probe based on aggregation-induced emission for leucine aminopeptidase in living cells and tumor tissue
    Anal Chim Acta (2018) 1031, 169-177. PubMed  Europe PubMed DOI  L
  59. Leung,L.L.K. and Morser,J.
    Carboxypeptidase B2 and carboxypeptidase N in the cross-talk between coagulation, thrombosis, inflammation and innate immunity
    J Thromb Haemost (2018) PubMed  Europe PubMed DOI
  60. Raffa,R.B., Pergolizzi JV Jr, Taylor R Jr and Ossipov,M.H.
    Indirect-acting strategy of opioid action instead of direct receptor activation: dual-acting enkephalinase inhibitors (DENKIs)
    J Clin Pharm Ther (2018) 43, 443-449. PubMed  Europe PubMed DOI  I
  61. Salomon,E., Schmitt,M., Marapaka,A.K., Stamogiannos,A., Revelant,G., Schmitt,C., Alavi,S., Florent,I., Addlagatta,A., Stratikos,E., Tarnus,C. and Albrecht,S.
    Aminobenzosuberone scaffold as a modular chemical tool for the inhibition of therapeutically relevant M1 aminopeptidases
    Molecules (2018) 23 PubMed  Europe PubMed DOI  I
  62. Schreiber,C.L. and Smith,B.D.
    Molecular imaging of aminopeptidase N in cancer and angiogenesis
    Contrast Media Mol Imaging (2018) 2018, 5315172-5315172. PubMed  Europe PubMed DOI  PMC  EPMC  L
    63. 2017
  63. Farsa,O., Kana,J., Macko,I., Zelazkova,J., Podlipna,J., Cirkva,A., Maxa,J. and Stastnv,K.
    Synthesis and aminopeptidase N inhibiting activity of 3-(nitrophenoxymethyl)-[1,3,2]dioxaborolan-2-ols and their open analogues
    Acta Pol Pharm (2017) 74, 127-135. PubMed  Europe PubMed  I
  64. Feng,J., Chen,Y., Li,F., Cui,L., Shi,N., Kong,W. and Zhang,Y.
    Synthesis, characterization and in vitro evaluation of a novel glycol chitosan-EDTA conjugate to inhibit aminopeptidase-mediated degradation of thymopoietin oligopeptides
    Molecules (2017) 22 PubMed  Europe PubMed DOI  I
  65. He,X., Xu,Y., Shi,W. and Ma,H.
    Ultrasensitive detection of aminopeptidase N activity in urine and cells with a ratiometric fluorescence probe
    Anal Chem (2017) 89, 3217-3221. PubMed  Europe PubMed DOI  A
  66. He,X., Hu,Y., Shi,W., Li,X. and Ma,H.
    Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N
    Chem Commun (Camb) (2017) 53, 9438-9441. PubMed  Europe PubMed DOI  L
  67. Jia,X., Han,Q., Wang,Z., Qian,Y., Jia,Y., Wang,W. and Hu,Z.
    Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy
    Biomater Sci (2017) 5, 417-421. PubMed  Europe PubMed DOI  L
  68. Joshi,S., Chen,L., Winter,M.B., Lin,Y.L., Yang,Y., Shapovalova,M., Smith,P.M., Liu,C., Li,F. and Lebeau,A.M.
    The rational design of therapeutic peptides for aminopeptidase N using a substrate-based approach
    Sci Rep (2017) 7, 1424-1424. PubMed  Europe PubMed DOI  P  I
  69. Kamau,A.N., Park,J.E., Park,E.S., Yu,J.E., Rho,J. and Shin,H.J.
    Porcine amino peptidase N domain VII has critical role in binding and entry of porcine epidemic diarrhea virus
    Virus Res (2017) 227, 150-157. PubMed  Europe PubMed DOI
  70. Khatun,A., Rahman,M.S., Ryu,D.Y., Kwon,W.S. and Pang,M.G.
    Elevated aminopeptidase N affects sperm motility and early embryo development
    PLoS ONE (2017) 12, e0184294-e0184294. PubMed  Europe PubMed DOI  E
  71. Pascual,I., Valiente,P.A., Garcia,G., Valdes-Tresanco,M.E., Arrebola,Y., Diaz,L., Bounaadja,L., Uribe,R.M., Pacheco,M.C., Florent,I. and Charli,J.L.
    Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN)
    Biochimie (2017) 142, 216-225. PubMed  Europe PubMed DOI  I
  72. Santiago,C., Mudgal,G., Reguera,J., Recacha,R., Albrecht,S., Enjuanes,L. and Casasnovas,J.M.
    Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection
    Sci Rep (2017) 7, 46045-46045. PubMed  Europe PubMed DOI  PMC  EPMC  S
  73. Zhang,W., Liu,F., Zhang,C., Luo,J.G., Luo,J., Yu,W. and Kong,L.
    Near-infrared fluorescent probe with remarkable large Stokes shift and favorable water solubility for real-time tracking leucine aminopeptidase in living cells and in vivo
    Anal Chem (2017) 89, 12319-12326. PubMed  Europe PubMed DOI  A
  74. Zhou,Z., Wang,F., Yang,G., Lu,C., Nie,J., Chen,Z., Ren,J., Sun,Q., Zhao,C. and Zhu,W.H.
    A ratiometric fluorescent probe for monitoring leucine aminopeptidase in living cells and zebrafish model
    Anal Chem (2017) 89, 11576-11582. PubMed  Europe PubMed DOI  A
    75. 2016
  75. Cui,R., Zhang,P. and Li,Y.
    Role of carboxypeptidase N invasion and migration in breast cancer
    Anticancer Agents Med Chem (2016) 16, 1198-1202. PubMed  Europe PubMed  K
  76. Fiddler,C.A., Parfrey,H., Cowburn,A.S., Luo,D., Nash,G.B., Murphy,G. and Chilvers,E.R.
    The aminopeptidase CD13 induces homotypic aggregation in neutrophils and impairs collagen invasion
    PLoS ONE (2016) 11, e0160108-e0160108. PubMed  Europe PubMed DOI
  77. Gong,Q., Shi,W., Li,L. and Ma,H.
    Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe
    Chem Sci (2016) 7, 788-792. PubMed  Europe PubMed DOI  PMC  EPMC  A  L
  78. Hata,R., Nonaka,H., Takakusagi,Y., Ichikawa,K. and Sando,S.
    Design of a hyperpolarized molecular probe for detection of aminopeptidase N activity
    Angew Chem Int Ed Engl (2016) 55, 1765-1768. PubMed  Europe PubMed DOI  A
  79. Hou,J., Jin,K., Li,J., Jiang,Y., Li,X., Wang,X., Huang,Y., Zhang,Y. and Xu,W.
    LJNK, an indoline-2,3-dione-based aminopeptidase N inhibitor with promising antitumor potency
    Anticancer Drugs (2016) 27, 496-507. PubMed  Europe PubMed DOI  I
  80. Ma,C., Cao,J., Liang,X., Huang,Y., Wu,P., Li,Y., Xu,W. and Zhang,Y.
    Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation
    Eur J Med Chem (2016) 108, 21-27. PubMed  Europe PubMed DOI  I
  81. Shibata,M., Koike,M., Kusumi,S., Sato,N. and Uchiyama,Y.
    A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney
    Arch Histol Cytol (2016) 76, 1-8. DOI
  82. Tang,J., Qu,F., Tang,X., Zhao,Q., Wang,Y., Zhou,Y., Feng,J., Lu,S., Hou,D. and Liu,Z.
    Molecular characterization and dietary regulation of aminopeptidase N (APN) in the grass carp (Ctenopharyngodon idella)
    Gene (2016) 582, 77-84. PubMed  Europe PubMed DOI
    83. 2015
  83. Akita,S., Hattori,N., Masuda,T., Horimasu,Y., Nakashima,T., Iwamoto,H., Fujitaka,K., Miyake,M. and Kohno,N.
    MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model
    Cancer Sci (2015) 106, 921-928. PubMed  Europe PubMed DOI
  84. Bonnard,E., Poras,H., Nadal,X., Maldonado,R., Fournie-Zaluski,M.C. and Roques,B.P.
    Long-lasting oral analgesic effects of N-protected aminophosphinic dual enkephalinase inhibitors (DENKIs) in peripherally controlled pain
    Pharmacol Res Perspect (2015) 3, e00116-e00116. PubMed  Europe PubMed DOI  PMC  EPMC  I
  85. Chen,H., Wang,H., Qin,X.-J., Chen,C., Feng,L., Chen,L.-Z., Du,L.-P. and Li,M.-Y.
    A bestatin-based fluorescent probe for aminopeptidase N cell imaging
    Chin Chem Lett (2015) 26, 513-516. DOI  L  I
  86. Poras,H., Bonnard,E., Fournie-Zaluski,M.C. and Roques,B.P.
    Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route
    Eur J Med Chem (2015) 102, 58-67. PubMed  Europe PubMed DOI  I
  87. Revelant,G., Al-Lakkis-Wehbe,M., Schmitt,M., Alavi,S., Schmitt,C., Roux,L., Al-Masri,M., Schifano-Faux,N., Maiereanu,C., Tarnus,C. and Albrecht,S.
    Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors
    Bioorg Med Chem (2015) 23, 3192-3207. PubMed  Europe PubMed DOI  I
  88. Sun,Z.P., Zhang,J., Shi,L.H., Zhang,X.R., Duan,Y., Xu,W.F., Dai,G. and Wang,X.J.
    Aminopeptidase N inhibitor 4cc synergizes antitumor effects of 5-fluorouracil on human liver cancer cells through ROS-dependent CD13 inhibition
    Biomed Pharmacother (2015) 76, 65-72. PubMed  Europe PubMed DOI  I
  89. Tang,X., Qu,Q., Kuang,B., Li,S. and Tu,G.
    3D-QSAR studies on flavone-8-acetic acid derivatives of aminopeptidase N inhibitors
    Med Chem (2015) 11, 764-770. PubMed  Europe PubMed  I
  90. Wang,H., Xu,W., Cao,J. and Wang,W.
    Rapid screening of aminopeptidase N inhibitors by capillary electrophoresis with electrophoretically mediated microanalysis
    Electrophoresis (2015) 36, 319-325. PubMed  Europe PubMed DOI  I
    91. 2014
  91. Cui,D.X., Wang,X.J., Zhang,X.R., Zhao,T.K., Guo,X.X., Liu,S.M., Wang,B., Ma,W.Q. and Gao,Z.Q.
    Preliminary detection of the anti-tumour activity of indoline-2,3-dione derivative DH-12a targeting aminopeptidase N
    Mol Med Rep (2014) 10, 2681-2688. PubMed  Europe PubMed DOI  I
  92. Cui,S.X., Zhang,H.L., Xu,W.F. and Qu,X.J.
    13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting aminopeptidase N (APN/CD13)
    Eur J Pharmacol (2014) 734, 50-59. PubMed  Europe PubMed DOI
  93. Hitzerd,S.M., Verbrugge,S.E., Ossenkoppele,G., Jansen,G. and Peters,G.J.
    Positioning of aminopeptidase inhibitors in next generation cancer therapy
    Amino Acids (2014) 46, 793-808. PubMed  Europe PubMed DOI  I
  94. Li,J., Chen,L., Wu,W., Zhang,W., Ma,Z., Cheng,Y., Du,L. and Li,M.
    Discovery of bioluminogenic probes for aminopeptidase N imaging
    Anal Chem (2014) 86, 2747-2751. PubMed  Europe PubMed DOI  L
  95. Liu,C., Yang,Y., Chen,L., Lin,Y.L. and Li,F.
    A unified mechanism for aminopeptidase N-based tumor cell motility and tumor-homing therapy
    J Biol Chem (2014) 289, 34520-34529. PubMed  Europe PubMed DOI  S
  96. Poras,H., Bonnard,E., Dange,E., Fournie-Zaluski,M.C. and Roques,B.P.
    New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment
    J Med Chem (2014) 57, 5748-5763. PubMed  Europe PubMed DOI  I
    97. 2013
  97. Chen,L., Sun,W., Li,J., Liu,Z., Ma,Z., Zhang,W., Du,L., Xu,W., Fang,H. and Li,M.
    The first ratiometric fluorescent probes for aminopeptidase N cell imaging
    Org Biomol Chem (2013) 11, 378-382. PubMed  Europe PubMed DOI  A  L
  98. Chen,L.Z., Du,L.P. and Li,M.Y.
    The first inhibitor-based fluorescent imaging probe for aminopeptidase N
    Drug Discov Ther (2013) 7, 124-125. PubMed  Europe PubMed  I
  99. Hahnenkamp,A., Schafers,M., Bremer,C. and Holtke,C.
    Design and synthesis of small-molecule fluorescent photoprobes targeted to aminopeptdase N (APN/CD13) for optical imaging of angiogenesis
    Bioconjug Chem (2013) 24, 1027-1038. PubMed  Europe PubMed DOI  L  I
  100. Halder,A.K., Saha,A. and Jha,T.
    Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors
    Mol Divers (2013) 17, 123-137. PubMed  Europe PubMed DOI  I
  101. Hu,Z., Yang,W., Ma,X., Ma,W., Qu,X., Liang,J., Wang,J. and Tian,J.
    Cerenkov luminescence tomography of aminopeptidase N (APN/CD13) expression in mice bearing HT1080 tumors
    Mol Imaging (2013) 12, 173-181. PubMed  Europe PubMed  L
  102. Jin,K., Zhang,X., Ma,C., Xu,Y., Yuan,Y. and Xu,W.
    Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN)
    Bioorg Med Chem (2013) 21, 2663-2670. PubMed  Europe PubMed DOI  I
  103. Kolb,A.F., Sorrell,D., Lassnig,C., Lillico,S., Carlisle,A., Neil,C., Robinson,C., Muller,M. and Whitelaw,C.B.
    Mammary gland development is delayed in mice deficient for aminopeptidase N
    Transgenic Res (2013) 22, 425-434. PubMed  Europe PubMed DOI  K
  104. Lai,A., Hosseini-Tabatabaei,A., Hartwell,R., Rahmani-Neishaboor,E., Kilani,R.T. and Ghahary,A.
    Topical application of aminopeptidase N-neutralizing antibody accelerates wound closure
    Mol Cell Biochem (2013) 372, 95-100. PubMed  Europe PubMed DOI  T
  105. Logsdon,L.A. and Urbach,A.R.
    Sequence-specific inhibition of a nonspecific protease
    J Am Chem Soc (2013) 135, 11414-11416. PubMed  Europe PubMed DOI  I
  106. Ma,C., Jin,K., Cao,J., Zhang,L., Li,X. and Xu,W.
    Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN)
    Bioorg Med Chem (2013) 21, 1621-1627. PubMed  Europe PubMed DOI  I
  107. Ma,C., Li,X., Liang,X., Jin,K., Cao,J. and Xu,W.
    Novel beta-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN)
    Bioorg Med Chem Lett (2013) 23, 4948-4952. PubMed  Europe PubMed DOI  I
  108. Su,L., Jia,Y., Wang,X., Zhang,L., Fang,H. and Xu,W.
    Discovery of a synthetic aminopeptidase N inhibitor LB-4b as a potential anticancer agent
    Bioorg Med Chem Lett (2013) 23, 2512-2517. PubMed  Europe PubMed DOI  I
  109. Zhang,X., Zhang,L., Zhang,J., Feng,J., Yuan,Y., Fang,H. and Xu,W.
    Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors
    J Enzyme Inhib Med Chem (2013) 28, 545-551. PubMed  Europe PubMed DOI  I
    110. 2012
  110. Albrecht,S., Salomon,E., Defoin,A. and Tarnus,C.
    Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors
    Bioorg Med Chem (2012) 20, 4942-4953. PubMed  Europe PubMed DOI  I
  111. Chen,L., Lin,Y.L., Peng,G. and Li,F.
    Structural basis for multifunctional roles of mammalian aminopeptidase N
    Proc Natl Acad Sci U S A (2012) 109, 17966-17971. PubMed  Europe PubMed DOI
  112. Feng,J., Jin,K., Zhu,H., Zhang,X., Zhang,L., Liu,J. and Xu,W.
    A novel aminopeptidase N inhibitor developed by virtual screening approach
    Bioorg Med Chem Lett (2012) 22, 5863-5869. PubMed  Europe PubMed DOI  I
  113. Gredicak,M., Abramic,M. and Jeric,I.
    Cyclic enediyne-amino acid chimeras as new aminopeptidase N inhibitors
    Amino Acids (2012) 43, 2087-2100. PubMed  Europe PubMed DOI  I
  114. Li,Q., Fang,H., Wang,X., Hu,G., Wang,Q. and Xu,W.
    Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation
    Bioorg Med Chem Lett (2012) 22, 850-853. PubMed  Europe PubMed DOI  I
  115. Roques,B.P., Fournie-Zaluski,M.C. and Wurm,M.
    Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain
    Nat Rev Drug Discov (2012) 11, 292-310. PubMed  Europe PubMed DOI  I
  116. Su,L., Jia,Y., Zhang,L., Xu,Y., Fang,H. and Xu,W.
    Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors
    Bioorg Med Chem (2012) 20, 3807-3815. PubMed  Europe PubMed DOI  I
  117. Turner,A.J.
    Aminopeptidase N
    [ISSN:978-0-12-407744-7] (2012) 3, 397-403. DOI
  118. Wong,A.H., Zhou,D. and Rini,J.M.
    The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing
    J Biol Chem (2012) 287, 36804-36813. PubMed  Europe PubMed DOI  S  I
  119. Yang,K., Fen,J., Fang,H., Zhang,L., Gong,J. and Xu,W.
    Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors
    J Enzyme Inhib Med Chem (2012) 27, 302-310. PubMed  Europe PubMed DOI  I
    120. 2011
  120. Albrecht,S., Al-Lakkis-Wehbe,M., Orsini,A., Defoin,A., Pale,P., Salomon,E., Tarnus,C. and Weibel,J.M.
    Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13
    Bioorg Med Chem (2011) 19, 1434-1449. PubMed  Europe PubMed DOI  I
  121. Chen,L.Z., Mou,J.J., Xu,Y.Y., Fang,H. and Xu,W.F.
    Design, synthesis and activity study of aminopeptidase N targeted 3-amino-2-hydroxy-4-phenyl-butanoic acid derivatives
    Drug Discov Ther (2011) 5, 61-65. PubMed  Europe PubMed  I
  122. Jia,M., Yang,K., Fang,H., Xu,Y., Sun,S., Su,L. and Xu,W.
    Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine
    Bioorg Med Chem (2011) 19, 5190-5198. PubMed  Europe PubMed DOI  I
  123. Li,X., Wang,J., Zhang,L. and Xu,W.
    Design, synthesis, and preliminary activity evaluation of novel peptidomimetics as aminopeptidase N/CD13 inhibitors
    Arch Pharm (Weinheim) (2011) 344, 494-504. PubMed  Europe PubMed DOI  I
  124. Luan,Y., Ma,C., Sui,Z., Wang,X., Feng,J., Liu,N., Jing,F., Wang,Y., Li,M., Fang,H. and Xu,W.
    LYP3, a new bestatin derivative for aminopeptidase N inhibition
    Med Chem (2011) 7, 32-36. PubMed  Europe PubMed  I
  125. Luan,Y., Wang,Q., Liu,N., Mou,J., Jiao,X., Fang,H., Li,M. and Xu,W.
    Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor
    Anticancer Drugs (2011) 22, 99-103. PubMed  Europe PubMed DOI  I
  126. Piedfer,M., Dauzonne,D., Tang,R., N'guyen,J., Billard,C. and Bauvois,B.
    Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells
    FASEB J (2011) 25, 2831-2842. PubMed  Europe PubMed DOI
  127. Rao,M., Li,Q., Feng,L., Xia,X., Ruan,L., Sheng,X. and Ge,M.
    A new aminopeptidase inhibitor from Streptomyces strain HCCB10043 found by UPLC-MS
    Anal Bioanal Chem (2011) 401, 699-706. PubMed  Europe PubMed DOI  I
  128. Ren,X., Liu,B., Yin,J., Zhang,H. and Li,G.
    Phage displayed peptides recognizing porcine aminopeptidase N inhibit transmissible gastroenteritis coronavirus infection in vitro
    Virology (2011) 410, 299-306. PubMed  Europe PubMed DOI
  129. Su,L., Fang,H., Yang,K., Xu,Y. and Xu,W.
    Design, synthesis and biological evaluation of novel l-lysine ureido derivatives as aminopeptidase N inhibitors
    Bioorg Med Chem (2011) 19, 900-906. PubMed  Europe PubMed DOI  I
  130. Wickstrom,M., Larsson,R., Nygren,P. and Gullbo,J.
    Aminopeptidase N (CD13) as a target for cancer chemotherapy
    Cancer Sci (2011) 102, 501-508. PubMed  Europe PubMed DOI  V  T
  131. Zhang,X., Zhang,J., Zhang,L., Feng,J., Xu,Y., Yuan,Y., Fang,H. and Xu,W.
    Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors
    Bioorg Med Chem (2011) 19, 6015-6025. PubMed  Europe PubMed DOI  I
    132. 2010
  132. Cui,S.X., Qu,X.J., Gao,Z.H., Zhang,Y.S., Zhang,X.F., Zhao,C.R., Xu,W.F., Li,Q.B. and Han,J.X.
    Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells
    Cancer Lett (2010) 292, 153-162. PubMed  Europe PubMed DOI  I
  133. Drag,M., Bogyo,M., Ellman,J.A. and Salvesen,G.S.
    Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors
    J Biol Chem (2010) 285, 3310-3318. PubMed  Europe PubMed DOI  P
  134. Grzywa,R., Oleksyszyn,J., Salvesen,G.S. and Drag,M.
    Identification of very potent inhibitor of human aminopeptidase N (CD13)
    Bioorg Med Chem Lett (2010) 20, 2497-2499. PubMed  Europe PubMed DOI  I
  135. Grzywa,R., Sokol,A.M., Sienczyk,M., Radziszewicz,M., Kosciolek,B., Carty,M.P. and Oleksyszyn,J.
    New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13
    Bioorg Med Chem (2010) 18, 2930-2936. PubMed  Europe PubMed DOI  I
  136. Haraguchi,N., Ishii,H., Mimori,K., Tanaka,F., Ohkuma,M., Kim,H.M., Akita,H., Takiuchi,D., Hatano,H., Nagano,H., Barnard,G.F., Doki,Y. and Mori,M.
    CD13 is a therapeutic target in human liver cancer stem cells
    J Clin Invest (2010) 120, 3326-3339. PubMed  Europe PubMed DOI  PMC  EPMC  T
  137. Inagaki,Y., Tang,W., Zhang,L., Du,G., Xu,W. and Kokudo,N.
    Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis
    Biosci Trends (2010) 4, 56-60. PubMed  Europe PubMed  I
  138. Jia,M.R., Wei,T. and Xu,W.F.
    The analgesic activity of bestatin as a potent APN inhibitor
    Front Neurosci (2010) 4, 50-50. PubMed  Europe PubMed DOI  PMC  EPMC  I
  139. Lai,A., Ghaffari,A. and Ghahary,A.
    Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration
    Mol Cell Biochem (2010) 343, 191-199. PubMed  Europe PubMed DOI
  140. Li,Q., Fang,H., Wang,X. and Xu,W.
    Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II
    Eur J Med Chem (2010) 45, 1618-1626. PubMed  Europe PubMed DOI  I
  141. Padia,S.H., Howell,N.L., Kemp,B.A., Fournie-Zaluski,M.C., Roques,B.P. and Carey,R.M.
    Intrarenal aminopeptidase N inhibition restores defective angiotensin II type 2-mediated natriuresis in spontaneously hypertensive rats
    Hypertension (2010) 55, 474-480. PubMed  Europe PubMed DOI  I
  142. Wang,Q., Xu,F., Mou,J., Zhang,J., Shang,L., Luan,Y., Yuan,Y., Liu,Y., Li,M., Fang,H., Wang,B. and Xu,W.
    Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors
    Protein Pept Lett (2010) 17, 847-853. PubMed  Europe PubMed DOI  I
  143. Wang,X., Zhang,L., Yang,K., Zhang,C., Zhang,J., Fang,H. and Xu,W.
    The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor
    Biol Pharm Bull (2010) 33, 1658-1665. PubMed  Europe PubMed  I
  144. Zhang,X., Fang,H., Zhu,H., Wang,X., Zhang,L., Li,M., Li,Q., Yuan,Y. and Xu,W.
    Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione
    Bioorg Med Chem (2010) 18, 5981-5987. PubMed  Europe PubMed DOI  I
    145. 2009
  145. Ansorge,S., Bank,U., Heimburg,A., Helmuth,M., Koch,G., Tadje,J., Lendeckel,U., Wolke,C., Neubert,K., Faust,J., Fuchs,P., Reinhold,D., Thielitz,A. and Tager,M.
    Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions
    Clin Chem Lab Med (2009) 47, 253-261. PubMed  Europe PubMed DOI
  146. Li,Q., Fang,H., Wang,X., Hu,L. and Xu,W.
    Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I
    Eur J Med Chem (2009) 44, 4819-4825. PubMed  Europe PubMed DOI  I
  147. Li,S.H., Li,G., Huang,H.M., Xiong,F., Mai,X., Kuang,B.H., Liu,C.M. and Tu,G.G.
    Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors
    Pharmazie (2009) 64, 67-70. PubMed  Europe PubMed DOI  I
  148. Li,X., Wang,Y., Wu,J., Li,Y., Wang,Q. and Xu,W.
    Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II)
    Bioorg Med Chem (2009) 17, 3061-3071. PubMed  Europe PubMed DOI  I
  149. Li,X., Wang,J., Li,J., Wu,J., Li,Y., Zhu,H., Fan,R. and Xu,W.
    Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I)
    Bioorg Med Chem (2009) 17, 3053-3060. PubMed  Europe PubMed DOI  I
  150. Liu,B., Li,G., Sui,X., Yin,J., Wang,H. and Ren,X.
    Expression and functional analysis of porcine aminopeptidase N produced in prokaryotic expression system
    J Biotechnol (2009) 141, 91-96. PubMed  Europe PubMed DOI  E
  151. Liu,Y., Shang,L., Fang,H., Zhu,H., Mu,J., Wang,Q., Wang,X., Yuan,Y. and Xu,W.
    Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13
    Bioorg Med Chem (2009) 17, 7398-7404. PubMed  Europe PubMed DOI  I
  152. Luan,Y., Wang,X., Zhu,H., Qu,X., Fang,H. and Xu,W.
    The synthesis and activity evaluation of a bestatin derivative (LYP) as an aminopeptidase N inhibitor
    Lett Drug Des Discov (2009) 6, 420-423. DOI  I
  153. Morikawa,T., Xie,H., Wang,T., Matsuda,H. and Yoshikawa,M.
    Acylated flavonol bisdesmosides, sinocrassosides A3-A7 and B3, with aminopeptidase N inhibitory activity from Sinocrassula indica
    Chem Biodivers (2009) 6, 411-420. PubMed  Europe PubMed DOI  I
  154. Mou,J., Fang,H., Jing,F., Wang,Q., Liu,Y., Zhu,H., Shang,L., Wang,X. and Xu,W.
    Design, synthesis and primary activity evaluation of l-arginine derivatives as amino-peptidase N/CD13 inhibitors
    Bioorg Med Chem (2009) 17, 4666-4673. PubMed  Europe PubMed DOI  I
  155. Shang,L., Fang,H., Zhu,H., Wang,X., Wang,Q., Mu,J., Wang,B., Kishioka,S. and Xu,W.
    Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors
    Bioorg Med Chem (2009) 17, 2775-2784. PubMed  Europe PubMed DOI  I
  156. Yang,K., Wang,Q., Su,L., Fang,H., Wang,X., Gong,J., Wang,B. and Xu,W.
    Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors
    Bioorg Med Chem (2009) 17, 3810-3817. PubMed  Europe PubMed DOI  I
    157. 2008
  157. Danziger,R.S.
    Aminopeptidase N in arterial hypertension
    Heart Fail Rev (2008) 13, 293-298. PubMed  Europe PubMed DOI  V
  158. Grzywa,R. and Oleksyszyn,J.
    First synthesis of alpha-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group
    Bioorg Med Chem Lett (2008) 18, 3734-3736. PubMed  Europe PubMed DOI  I
  159. John,H., John,S. and Forssmann,W.G.
    Kinetic studies on aminopeptidase M-mediated degradation of human hemorphin LVV-H7 and its N-terminally truncated products
    J Pept Sci (2008) 14, 797-803. PubMed  Europe PubMed DOI
  160. Mina-Osorio,P.
    The moonlighting enzyme CD13: old and new functions to target
    Trends Mol Med (2008) 14, 361-371. PubMed  Europe PubMed DOI
  161. Shang,L., Maeda,T., Xu,W. and Kishioka,S.
    Evaluation of a novel aminopeptidase N inhibitor, in vitro, using two assay systems
    J Enzyme Inhib Med Chem (2008) 23, 198-205. PubMed  Europe PubMed DOI  A  I
  162. Shang,L., Wang,Q., Fang,H., Mu,J., Wang,X., Yuan,Y., Wang,B. and Xu,W.
    Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN)
    Bioorg Med Chem (2008) 16, 9984-9990. PubMed  Europe PubMed DOI  I
  163. Shim,J.S., Park,H.M., Lee,J. and Kwon,H.J.
    Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition
    Biochem Biophys Res Commun (2008) 371, 99-103. PubMed  Europe PubMed DOI  I
  164. Tu,G., Li,S., Huang,H., Li,G., Xiong,F., Mai,X., Zhu,H., Kuang,B. and Xu,W.F.
    Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold
    Bioorg Med Chem (2008) 16, 6663-6668. PubMed  Europe PubMed DOI  I
  165. Willemse,J.L., Chen,D. and Hendriks,D.F.
    Major carboxypeptidase N deficiency
    Clin Chim Acta (2008) 389, 181-182. PubMed  Europe PubMed DOI  M
  166. Wulfaenger,J., Niedling,S., Riemann,D. and Seliger,B.
    Aminopeptidase N (APN)/CD13-dependent CXCR4 downregulation is associated with diminished cell migration, proliferation and invasion
    Mol Membr Biol (2008) 25, 72-82. PubMed  Europe PubMed DOI
  167. Zhang,X. and Xu,W.
    Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design
    Curr Med Chem (2008) 15, 2850-2865. PubMed  Europe PubMed DOI  V  I
    168. 2007
  168. Kotlo,K., Shukla,S., Tawar,U., Skidgel,R.A. and Danziger,R.S.
    Aminopeptidase N reduces basolateral Na+-K+-ATPase in proximal tubule cells
    Am J Physiol Renal Physiol (2007) 293, F1047-F1053. PubMed  Europe PubMed DOI
  169. Li,B.X., Ge,J.W. and Li,Y.J.
    Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus
    Virology (2007) 365, 166-172. PubMed  Europe PubMed DOI
  170. Luan,Y. and Xu,W.
    The structure and main functions of aminopeptidase N
    Curr Med Chem (2007) 14, 639-647. PubMed  Europe PubMed DOI  V
  171. Petrovic,N., Schacke,W., Gahagan,J.R., O'Conor,C.A., Winnicka,B., Conway,R.E., Mina-Osorio,P. and Shapiro,L.H.
    CD13/APN regulates endothelial invasion and filopodia formation
    Blood (2007) 110, 142-150. PubMed  Europe PubMed DOI  PMC  EPMC
  172. Proost,P., Mortier,A., Loos,T., Vandercappellen,J., Gouwy,M., Ronsse,I., Schutyser,E., Put,W., Parmentier,M., Struyf,S. and Van Damme,J.
    Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration
    Blood (2007) 110, 37-44. PubMed  Europe PubMed DOI
  173. Rangel,R., Sun,Y., Guzman-Rojas,L., Ozawa,M.G., Sun,J., Giordano,R.J., Van Pelt,C.S., Tinkey,P.T., Behringer,R.R., Sidman,R.L., Arap,W. and Pasqualini,R.
    Impaired angiogenesis in aminopeptidase N-null mice
    Proc Natl Acad Sci U S A (2007) 104, 4588-4593. PubMed  Europe PubMed DOI  PMC  EPMC  K
  174. Reinhold,D., Biton,A., Goihl,A., Pieper,S., Lendeckel,U., Faust,J., Neubert,K., Bank,U., Tager,M., Ansorge,S. and Brocke,S.
    Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses
    Ann N Y Acad Sci (2007) 1110, 402-409. PubMed  Europe PubMed DOI
  175. Stragier,B., Demaegdt,H., De Bundel,D., Smolders,I., Sarre,S., Vauquelin,G., Ebinger,G., Michotte,Y. and Vanderheyden,P.
    Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat
    Brain Res (2007) 1131, 97-105. PubMed  Europe PubMed DOI  I
  176. Thielitz,A., Reinhold,D., Vetter,R., Bank,U., Helmuth,M., Hartig,R., Wrenger,S., Wiswedel,I., Lendeckel,U., Kahne,T., Neubert,K., Faust,J., Zouboulis,C.C., Ansorge,S. and Gollnick,H.
    Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation
    J Invest Dermatol (2007) 127, 1042-1051. PubMed  Europe PubMed DOI  T  I
    177. 2006
  177. Alfalah,M., Krahn,M.P., Wetzel,G., von Horsten,S., Wolke,C., Hooper,N., Kalinski,T., Krueger,S., Naim,H.Y. and Lendeckel,U.
    A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum
    J Biol Chem (2006) 281, 11894-11900. PubMed  Europe PubMed DOI  M
  178. [YEAR:20-12-2006]Bank,U., Heimburg,A., Helmuth,M., Stefin,S., Lendeckel,U., Reinhold,D., Faust,J., Fuchs,P., Sens,B., Neubert,K., Tager,M. and Ansorge,S.
    Triggering endogenous immunosuppressive mechanisms by combined targeting of dipeptidyl peptidase IV (DPIV/CD26) and aminopeptidase N (APN/ CD13) - a novel approach for the treatment of inflammatory bowel disease
    Int Immunopharmacol (20-12-2006) 6, 1925-1934. PubMed  Europe PubMed DOI  I
  179. [YEAR:7-10-2006]Bauvois,B. and Dauzonne,D.
    Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects
    Med Res Rev (7-10-2006) 26, 88-130. PubMed  Europe PubMed DOI  T  I
  180. [YEAR:8-8-2006]Kitabgi,P.
    Inactivation of neurotensin and neuromedin N by Zn metallopeptidases
    Peptides (8-8-2006) 27, 2515-2522. PubMed  Europe PubMed DOI  V
  181. Wisner,A., Dufour,E., Messaoudi,M., Nejdi,A., Marcel,A., Ungeheuer,M.N. and Rougeot,C.
    Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways
    Proc Natl Acad Sci U S A (2006) 103, 17979-17984. PubMed  Europe PubMed DOI  PMC  EPMC  I
    182. 2005
  182. Kato,M., Azuma,H., Akaike,M., Iuchi,T., Aihara,K., Ikeda,Y., Fujimura,M., Yoshida,T., Yamaguchi,H., Hashizume,S. and Matsumoto,T.
    Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression
    Atherosclerosis (2005) 183, 49-55. PubMed  Europe PubMed DOI
  183. [YEAR:3-1-2005]Lee,J., Shim,J.S., Jung,S.A., Lee,S.T. and Kwon,H.J.
    N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity
    Bioorg Med Chem Lett (3-1-2005) 15, 181-183. PubMed  Europe PubMed DOI  I
    184. 2004
  184. [YEAR:15-10-2004]Gredmark,S., Britt,W.B., Xie,X., Lindbom,L. and Soderberg-Naucler,C.
    Human cytomegalovirus induces inhibition of macrophage differentiation by binding to human aminopeptidase N/CD13
    J Immunol (15-10-2004) 173, 4897-4907. PubMed  Europe PubMed
  185. Sakane,N., Asano,Y., Kawamura,T., Takatani,T., Kohama,Y., Tsujikawa,K. and Yamamoto,H.
    Aminopeptidase N/CD13 regulates the fetal liver microenvironment of hematopoiesis
    Biol Pharm Bull (2004) 27, 2014-2020. PubMed  Europe PubMed DOI
  186. Turner,A.J.
    Membrane alanyl aminopeptidase
    [ISSN:0-12-079610-4] (2004) 2, 289-294.  V
    187. 2003
  187. Bukowska,A., Tadje,J., Arndt,M., Wolke,C., Kahne,T., Bartsch,J., Faust,J., Neubert,K., Hashimoto,Y. and Lendeckel,U.
    Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets
    Biol Chem (2003) 384, 657-665. PubMed  Europe PubMed DOI  I
  188. Kawai,M., Otake,Y. and Hara,Y.
    High-molecular-mass isoform of aminopeptidase N/CD13 in serum from cholestatic patients
    Clin Chim Acta (2003) 330, 141-149. PubMed  Europe PubMed DOI
  189. Kido,A., Krueger,S., Haeckel,C. and Roessner,A.
    Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells
    Clin Exp Metastasis (2003) 20, 585-592. PubMed  Europe PubMed DOI
  190. Le Guen,S., Mas Nieto,M., Canestrelli,C., Chen,H., Fournie-Zaluski,M.C., Cupo,A., Maldonado,R., Roques,B.P. and Noble,F.
    Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone
    Pain (2003) 104, 139-148. PubMed  Europe PubMed DOI  I
    191. 2002
  191. [YEAR:1-4-2002]Firla,B., Arndt,M., Frank,K., Thiel,U., Ansorge,S., Tager,M. and Lendeckel,U.
    Extracellular cysteines define ectopeptidase (APN, CD13) expression and function
    Free Radic Biol Med (1-4-2002) 32, 584-595. PubMed  Europe PubMed DOI
  192. Janas,R.M., Socha,J., Janas,J. and Warnawin,K.
    Neutral endopeptidase activity is not elevated in serum in children with cholestatic liver disease: a unique role of aminopeptidase-M in sequential hydrolysis of peptides
    Dig Dis Sci (2002) 47, 1766-1774. PubMed  Europe PubMed DOI
  193. Lohn,M., Mueller,C. and Langner,J.
    Cell cycle retardation in monocytoid cells induced by aminopeptidase N (CD13)
    Leuk Lymphoma (2002) 43, 407-413. PubMed  Europe PubMed DOI
  194. Shimizu,T., Tani,K., Hase,K., Ogawa,H., Huang,L., Shinomiya,F. and Sone,S.
    CD13/aminopeptidase N-induced lymphocyte involvement in inflamed joints of patients with rheumatoid arthritis
    Arthritis Rheum (2002) 46, 2330-2338. PubMed  Europe PubMed DOI
    195. 2001
  195. [YEAR:1-2-2001]Bhagwat,S.V., Lahdenranta,J., Giordano,R., Arap,W., Pasqualini,R. and Shapiro,L.H.
    CD13/APN is activated by angiogenic signals and is essential for capillary tube formation
    Blood (1-2-2001) 97, 652-659. PubMed  Europe PubMed DOI
  196. Dybkaer,K., Kristensen,J.S. and Pedersen,F.S.
    Single site polymorphisms and alternative splicing of the human CD13 gene - different splicing frequencies among patients with acute myeloid leukaemia and healthy individuals
    Br J Haematol (2001) 112, 691-696. PubMed  Europe PubMed DOI  M
  197. Kawai,M., Hara,Y., Miyazato,I. and Hosaki,S.
    Novel, aberrantly truncated isoform of serum CD13 in a family with high serum aminopeptidase N (CD13) activity
    Clin Chem (2001) 47, 223-230. PubMed  Europe PubMed
  198. Kehlen,A., Egbert,I., Thiele,K., Fischer,K., Riemann,D. and Langner,J.
    Increased expression of interleukin-8 and aminopeptidase N by cell-cell contact: interleukin-8 is resistant to degradation by aminopeptidase N/CD13
    Eur Cytokine Netw (2001) 12, 316-324. PubMed  Europe PubMed
  199. [YEAR:15-5-2001]Matthews,K.W. and Wetsel,R.A.
    Characterization of mouse carboxypeptidase N small active subunit gene structure
    J Immunol (15-5-2001) 166, 6196-6202. PubMed  Europe PubMed
  200. Najjar,S.M., Broyart,J.P., Hampp,L.T. and Gray,G.M.
    Intestinal aminooligopeptidase in diabetic BioBreed rat: altered posttranslational processing and trafficking
    Am J Physiol Gastrointest Liver Physiol (2001) 280, G104-G112. PubMed  Europe PubMed
  201. van der Velden,V.H., Leenen,P.J. and Drexhage,H.A.
    CD13/aminopeptidase N involvement in dendritic cell maturation
    Leukemia (2001) 15, 190-191. PubMed  Europe PubMed DOI
  202. Wentworth,D.E. and Holmes,K.V.
    Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation
    J Virol (2001) 75, 9741-9752. PubMed  Europe PubMed DOI  PMC  EPMC
    203. 2000
  203. [YEAR:6-4-2000]Chen,H., Noble,F., Mothe,A., Meudal,H., Coric,P., Danascimento,S., Roques,B.P., George,P. and Fournie-Zaluski,M.C.
    Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities
    J Med Chem (6-4-2000) 43, 1398-1408. PubMed  Europe PubMed DOI  I
  204. [YEAR:24-6-2000]Lendeckel,U., Scholz,B., Arndt,M., Frank,K., Spiess,A., Chen,H., Roques,B.P. and Ansorge,S.
    Inhibition of alanyl-aminopeptidase suppresses the activation-dependent induction of glycogen synthase kinase-3beta (GSK-3beta) in human T cells
    Biochem Biophys Res Commun (24-6-2000) 273, 62-65. PubMed  Europe PubMed DOI  I
  205. [YEAR:10-4-2000]Santos,A.N., Langner,J., Herrmann,M. and Riemann,D.
    Aminopeptidase N/CD13 is directly linked to signal transduction pathways in monocytes
    Cell Immunol (10-4-2000) 201, 22-32. PubMed  Europe PubMed DOI
    206. 1999
  206. [YEAR:7-6-1999]Chen,H., Roques,B.P. and Fournie-Zaluski,M.C.
    Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor
    Bioorg Med Chem Lett (7-6-1999) 9, 1511-1516. PubMed  Europe PubMed DOI  I
  207. [YEAR:1-11-1999]de Gandarias,J.M., Irazusta,J., Gil,J., Fernandez,D., Varona,A. and Casis,L.
    Ontogeny of puromycin-sensitive and insensitive aminopeptidase activities in several subcellular fractions of the rat brain
    Brain Res Bull (1-11-1999) 50, 283-290. PubMed  Europe PubMed DOI
  208. Douglas,S.E., Gallant,J.W. and Bullerwell,C.E.
    Molecular investigation of aminopeptidase N expression in the winter flounder, Pleuronectes americanus
    J Appl Ichthyol (1999) 15, 80-86.
  209. Reaux,A., de Mota,N., Zini,S., Cadel,S., Fournie-Zaluski,M.C., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III
    Neuroendocrinology (1999) 69, 370-376. PubMed  Europe PubMed DOI  I
  210. Shimazawa,R., Takayama,H., Fujimoto,Y., Komoda,M., Dodo,K., Yamasaki,R., Shirai,R., Koiso,Y., Miyata,K., Kato,F., Kato,M., Miyachi,H. and Hashimoto,Y.
    Novel small molecule nonpeptide aminopeptidase N inhibitors with a cyclic imide skeleton
    J Enzyme Inhib (1999) 14, 259-275. PubMed  Europe PubMed  I
    211. 1998
  211. [YEAR:20-8-1998]Gillis,L.D., Pendley,D.S. and Funkhouser,J.D.
    The major APN transcript of the alveolar type II epithelial cell originates from a unique upstream promoter region
    Biochim Biophys Acta (20-8-1998) 1399, 126-140. PubMed  Europe PubMed DOI
  212. [YEAR:13-1-1998]Luciani,N., Marie-Claire,C., Ruffet,E., Beaumont,A., Roques,B.P. and Fournie-Zaluski,M.C.
    Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): Insights into its mechanism of action
    Biochemistry (13-1-1998) 37, 686-692. PubMed  Europe PubMed DOI
    213. 1997
  213. Benbacer,L., Kut,E., Besnardeau,L., Laude,H. and Delmas,B.
    Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus
    J Virol (1997) 71, 734-737. PubMed  Europe PubMed  PMC  EPMC
  214. Bernkop-Schnurch,A. and Marschutz,M.K.
    Development and in vitro evaluation of systems to protect peptide drugs from aminopeptidase N
    Pharm Res (1997) 14, 181-185. PubMed  Europe PubMed DOI
  215. Dimitrova,M., Dikov,A. and Salzer,M.
    Fluorescent demonstration of alanine aminopeptidase using a new substrate, based on a thioxanthene derivative
    C R Acad Bulg Sci (1997) 50, 97-100.  L
  216. Nagai,M., Kojima,F., Naganawa,H., Hamada,M., Aoyagi,T. and Takeuchi,T.
    Phebestin, a new inhibitor of aminopeptidase N, produced by Streptomyces sp. MJ716-m3
    J Antibiot (Tokyo) (1997) 50, 82-84. PubMed  Europe PubMed  I
  217. Noble,F. and Roques,B.P.
    Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice
    FEBS Lett (1997) 401, 227-229. PubMed  Europe PubMed DOI
  218. Parenti,P., Morandi,P., McGivan,J.D., Consonnic,P., Leonardi,G. and Giordana,B.
    Properties of the aminopeptidase N from the silkworm midgut (Bombyx mori)
    Insect Biochem Mol Biol (1997) 27, 397-403.  I
  219. Pemberton,P.W., Lobley,R.W., Sorensen,S.H. and Batt,R.M.
    An aminopeptidase N deficiency in dog small intestine
    Res Vet Sci (1997) 63, 133-138. PubMed  Europe PubMed  K
    220. 1996
  220. Dikov,A. and Dimitrova,M.
    New fluorogenic substrates in histochemistry of peptidases: I. Histochemical determination of alanine aminopeptidase
    C R Acad Bulg Sci (1996) 49, 89-92.  L
  221. Fujii,H., Nakajima,M., Aoyagi,T. and Tsuruo,T.
    Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors
    Biol Pharm Bull (1996) 19, 6-10. PubMed  Europe PubMed  T  I
  222. Lendeckel,U., Wex,T., Reinhold,D., Kahne,T., Frank,K., Faust,J., Neubert,K. and Ansorge,S.
    Induction of the membrane alanyl aminopeptidase gene and surface expression in human T-cells by mitogenic activation
    Biochem J (1996) 319, 817-821. PubMed  Europe PubMed  PMC  EPMC  I
  223. Lerche,C., Vogel,L.K., Shapiro,L.H., Noren,O. and Sjostrom,H.
    Human aminopeptidase N is encoded by 20 exons
    Mamm Genome (1996) 7, 712-713. PubMed  Europe PubMed
    224. 1995
  224. Piela-Smith,T.H. and Korn,J.H.
    Aminopeptidase N: A constitutive cell-surface protein on human dermal fibroblasts
    Cell Immunol (1995) 162, 42-48. PubMed  Europe PubMed DOI
  225. Safavi,A. and Hersh,L.B.
    Degradation of dynorphin-related peptides by the puromycin-sensitive aminopeptidase and aminopeptidase M
    J Neurochem (1995) 65, 389-395. PubMed  Europe PubMed
  226. Watanabe,Y., Iwaki-Egawa,S., Mizukoshi,H. and Fujimoto,Y.
    Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N
    Biol Chem Hoppe Seyler (1995) 376, 397-400. PubMed  Europe PubMed
    227. 1994
  227. Chauvel,E.N., Llorens-Cortes,C., Coric,P., Wilk,S., Roques,B.P. and Fournie-Zaluski,M.C.
    Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols
    J Med Chem (1994) 37, 2950-2957. PubMed  Europe PubMed  I
  228. [YEAR:15-3-1994]Hooper,N.M., Hesp,R.J. and Tieku,S.
    Metabolism of aspartame by human and pig intestinal microvillar peptidases
    Biochem J (15-3-1994) 298, 635-639. PubMed  Europe PubMed  PMC  EPMC
  229. [YEAR:1-3-1994]Murray,H., Turner,A.J. and Kenny,A.J.
    The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13)
    Biochem J (1-3-1994) 298, 353-360. PubMed  Europe PubMed  PMC  EPMC  I
  230. O'Callaghan,B., Synguelakis,M., Le Gal la Salle,G. and Morel,N.
    Characterization of aminopeptidase N from Torpedo marmorata kidney
    Biol Cell (1994) 81, 121-130. PubMed  Europe PubMed DOI
  231. Schalk,C., D'Orchymont,H., Jauch,M.F. and Tarnus,C.
    3-Amino-2-tetralone derivatives: novel potent and selective inhibitors of aminopeptidase-M (EC 3.4.11.2)
    Arch Biochem Biophys (1994) 311, 42-46. PubMed  Europe PubMed DOI  I
    232. 1993
  232. Favaloro,E.J., Browning,T. and Facey,D.
    CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated
    Exp Hematol (1993) 21, 1695-1701. PubMed  Europe PubMed
    233. 1992
  233. [YEAR:4-6-1992]Delmas,B., Gelfi,J., L'Haridon,R., Vogel,L.K., Sjostrom,H., Noren,O. and Laude,H.
    Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV
    Nature (4-6-1992) 357, 417-420. PubMed  Europe PubMed DOI
  234. Gillespie,T.J., Konings,P.N., Merrill,B.J. and Davis,T.P.
    A specific enzyme assay for aminopeptidase M in rat brain
    Life Sci (1992) 51, 2097-2106. PubMed  Europe PubMed DOI  I
  235. Ocain,T.D. and Rich,D.H.
    alpha-Keto amide inhibitors of aminopeptidases
    J Med Chem (1992) 35, 451-456. PubMed  Europe PubMed  I
  236. [YEAR:10-8-1992]Vogel,L.K., Noren,O. and Sjostrom,H.
    The apical sorting signal on human aminopeptidase N is not located in the stalk but in the catalytic head group
    FEBS Lett (10-8-1992) 308, 14-17. PubMed  Europe PubMed DOI
  237. [YEAR:4-6-1992]Yeager,C.L., Ashmun,R.A., Williams,R.K., Cardellichio,C.B., Shapiro,L.H., Look,A.T. and Holmes,K.V.
    Human aminopeptidase N is a receptor for human coronavirus 229E
    Nature (4-6-1992) 357, 420-422. PubMed  Europe PubMed DOI
    238. 1991
  238. Funkhouser,J.D., Tangada,S.D., Jones,M., O,S.J. and Peterson,R.D.
    p146 type II alveolar epithelial cell antigen is identical to aminopeptidase N
    Am J Physiol (1991) 260, L274-L279. PubMed  Europe PubMed
    239. 1990
  239. Lenney,J.F.
    Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase)
    Biol Chem Hoppe Seyler (1990) 371, 433-440. PubMed  Europe PubMed
  240. Ward,P.E., Benter,I.F., Dick,L. and Wilk,S.
    Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M
    Biochem Pharmacol (1990) 40, 1725-1732. PubMed  Europe PubMed DOI  P
  241. Watt,V.M. and Willard,H.F.
    The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis
    Hum Genet (1990) 85, 651-654. PubMed  Europe PubMed  M
    242. 1989
  242. [YEAR:18-4-1989]Lejczak,B., Kafarski,P. and Zygmunt,J.
    Inhibition of aminopeptidases by aminophosphonates
    Biochemistry (18-4-1989) 28, 3549-3555. PubMed  Europe PubMed
  243. Look,A.T., Ashmun,R.A., Shapiro,L.H. and Peiper,S.C.
    Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N
    J Clin Invest (1989) 83, 1299-1307. PubMed  Europe PubMed DOI  PMC  EPMC
  244. Malfroy,B., Kado-Fong,H., Gros,C., Giros,B., Schwartz,J.C. and Hellmiss,R.
    Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases
    Biochem Biophys Res Commun (1989) 161, 236-241. PubMed  Europe PubMed
    245. 1988
  245. [YEAR:7-11-1988]Kruse,T.A., Bolund,L., Grzeschik,K.H., Ropers,H.H., Olsen,J., Sjostrom,H. and Noren,O.
    Assignment of the human aminopeptidase N (peptidase E) gene to chromosome 15q13-qter
    FEBS Lett (7-11-1988) 239, 305-308. PubMed  Europe PubMed
  246. Ocain,T.D. and Rich,D.H.
    Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues
    J Med Chem (1988) 31, 2193-2199. PubMed  Europe PubMed  I
  247. Olsen,J., Cowell,G.M., Koenigshoefer,E., Danielsen,E.M., Moeller,J., Laustsen,L., Hansen,O.C., Welinder,K.G., Engberg,J., Hunziker,W., Spiess,M., Sjoestroem,H. and Noren,O.
    Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA
    FEBS Lett (1988) 238, 307-314. PubMed  Europe PubMed
    248. 1986
  248. McDonald,J.K. and Barrett,A.J.
    Mammalian Proteases: a Glossary and Bibliography. Volume 2: Exopeptidases
    [ISSN:ISBN 0-12-079502-7] (1986)
    249. 1985
  249. [YEAR:25-10-1985]Wilkes,S.H. and Prescott,J.M.
    The slow, tight binding of bestatin and amastatin to aminopeptidases
    J Biol Chem (25-10-1985) 260, 13154-13162. PubMed  Europe PubMed  I
    250. 1984
  250. [YEAR:11-6-1984]Antonov,V.K., Vorotyntseva,T.I., Bessmertnaya,L.Y., Mikhailova,A.G. and Zilberman,M.I.
    Role of intestinal brush border membrane aminopeptidase N in dipeptide transport
    FEBS Lett (11-6-1984) 171, 227-232. PubMed  Europe PubMed DOI
  251. Jung,K., Pergande,M. and Wischke,U.W.
    Characterization of particulate and soluble variants of the brush-border enzymes alanine aminopeptidase, alkaline phosphatase and gamma-glutamyltransferase in human urine
    Biomed Biochim Acta (1984) 43, 1357-1364. PubMed  Europe PubMed
  252. Rich,D.H., Moon,B.J. and Harbeson,S.
    Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes
    J Med Chem (1984) 27, 417-422. PubMed  Europe PubMed  I
    253. 1983
  253. [YEAR:15-3-1983]Leyhausen,G., Schuster,D.K., Vaith,P., Zahn,R.K., Umezawa,H., Falke,D. and Muller,W.E.
    Identification and properties of the cell membrane bound leucine aminopeptidase interacting with the potential immunostimulant and chemotherapeutic agent bestatin
    Biochem Pharmacol (15-3-1983) 32, 1051-1057. PubMed  Europe PubMed DOI  I
  254. [YEAR:22-11-1983]Miura,S., Song,I.S., Morita,A., Erickson,R.H. and Kim,Y.S.
    Distribution and biosynthesis of aminopeptidase N and dipeptidyl aminopeptidase IV in rat small intestine
    Biochim Biophys Acta (22-11-1983) 761, 66-75. PubMed  Europe PubMed DOI
  255. [YEAR:25-11-1983]Wilkes,S.H. and Prescott,J.M.
    Stereospecificity of amino acid hydroxamate inhibition of aminopeptidases
    J Biol Chem (25-11-1983) 258, 13517-13521. PubMed  Europe PubMed  I
    256. 1982
  256. [YEAR:26-7-1982]Gratecos,D., Varesi,L., Knibiehler,M. and Semeriva,M.
    Photoaffinity labeling of membrane-bound porcine aminopeptidase N
    Biochim Biophys Acta (26-7-1982) 705, 218-227. PubMed  Europe PubMed
  257. [YEAR:10-6-1982]Kozak,E.M. and Tate,S.S.
    Glutathione-degrading enzymes of microvillus membranes
    J Biol Chem (10-6-1982) 257, 6322-6327. PubMed  Europe PubMed
    258. 1981
  258. [YEAR:1-9-1981]Benajiba,A. and Maroux,S.
    Subunit structured of pig small-intestinal brush-border aminopeptidase N
    Biochem J (1-9-1981) 197, 573-580. PubMed  Europe PubMed  PMC  EPMC
  259. [YEAR:13-3-1981]Feracci,H., Benajiba,A., Gorvel,J.P., Doumeng,C. and Maroux,S.
    Enzymatic and immunological properties of the protease form of aminopeptidase N and A from pig and rabbit intestinal brush border
    Biochim Biophys Acta (13-3-1981) 658, 148-157. PubMed  Europe PubMed
  260. [YEAR:12-10-1981]Gaertner,H., Puigserver,A. and Maroux,S.
    Hydrolysis of the isopeptide bond of epsilon-N-L-methionyl-L-lysine by intestinal aminopeptidase N
    FEBS Lett (12-10-1981) 133, 135-138. PubMed  Europe PubMed
    261. 1980
  261. Feracci,H. and Maroux,S.
    Rabbit intestinal aminopeptidase N. Purification and molecular properties
    Biochim Biophys Acta (1980) 599, 448-463. PubMed  Europe PubMed
  262. [YEAR:27-5-1980]Maze,M. and Gray,G.M.
    Intestinal brush border aminooligopeptidases: cytosol precursors of the membrane enzyme
    Biochemistry (27-5-1980) 19, 2351-2358. PubMed  Europe PubMed
  263. [YEAR:1-11-1980]Plummer,T.H., Jr. and Kimmel,M.T.
    An improved spectrophotometric assay for human plasma carboxypeptidase N
    Anal Biochem (1-11-1980) 108, 348-353. PubMed  Europe PubMed DOI  A
    264. 1979
  264. [YEAR:1-3-1979]Miller,R. and Lacefield,W.
    Specific inhibitors of aminopeptidase M. Relationship to anti-inflammatory activity
    Biochem Pharmacol (1-3-1979) 28, 673-675. PubMed  Europe PubMed DOI  I
    265. 1977
  265. [YEAR:1-11-1977]Hiwada,K. and Kokubu,T.
    Comparison of soluble and membrane-bound neutral arylamidases from renal cell carcinoma
    Clin Chim Acta (1-11-1977) 80, 395-401. PubMed  Europe PubMed
  266. [YEAR:25-7-1977]Kania,R.K., Santiago,N.A. and Gray,G.M.
    Intestinal surface amino-oligopeptidases. II. Substrate kinetics and topography of the active site
    J Biol Chem (25-7-1977) 252, 4929-4934. PubMed  Europe PubMed  P
    267. 1976
  267. [YEAR:11-11-1976]Vannier,C., Louvard,D., Maroux,S. and Desnuelle,P.
    Structural and topological homology between porcine intestinal and renal brush border aminopeptidase
    Biochim Biophys Acta (11-11-1976) 455, 185-199. PubMed  Europe PubMed
  268. [YEAR:8-4-1976]Wacker,H., Lehky,P., Vanderhaeghe,F. and Stein,E.A.
    On the subunit structure of particulate aminopeptidase from pig kidney
    Biochim Biophys Acta (8-4-1976) 429, 546-554. PubMed  Europe PubMed
    269. 1975
  269. [YEAR:1-1-1975]Takesue,Y.
    Purification and properties of leucine beta-naphthylamidase from rabbit small-intestinal mucosal cells
    J Biochem (1-1-1975) 77, 103-115. PubMed  Europe PubMed
    270. 1974
  270. Femfert,U. and Cichocki,P.
    Hydrophobic areas at the active site of aminopeptidase M
    Hoppe Seylers Z Physiol Chem (1974) 355, 1332-1334. PubMed  Europe PubMed
  271. Starnes,W.L. and Behal,F.J.
    A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein
    Biochemistry (1974) 13, 3221-3227. PubMed  Europe PubMed
    272. 1973
  272. [YEAR:15-9-1973]Lehky,P., Lisowski,J., Wolf,D.P., Wacker,H. and Stein,E.A.
    Pig kidney particulate aminopeptidase. A zinc metalloenzyme
    Biochim Biophys Acta (15-9-1973) 321, 274-281. PubMed  Europe PubMed
    273. 1972
  273. [YEAR:1-10-1972]Femfert,U., Cichocki,P. and Pfleiderer,G.
    On the mechanism of amide bond cleavage catalyzed by aminopeptidase M. Enzymatic properties of nitroaminopeptidase M
    FEBS Lett (1-10-1972) 26, 39-42. PubMed  Europe PubMed
    274. 1971
  274. Femfert,U.
    On the mechanism of amide bond cleavage catalyzed by aminopeptidase M. Kinetic studies in deuteriumoxide
    FEBS Lett (1971) 14, 92-94. PubMed  Europe PubMed
  275. Femfert,U. and Pfleiderer,G.
    The effect of cations and complexing agents on the hydrolysis of L-alanine-4-nitroanilide by aminopeptidase M
    FEBS Lett (1971) 14, 89-91. PubMed  Europe PubMed
  276. Wacker,H., Lehky,P., Fischer,E.H. and Stein,E.A.
    Physical and chemical characterization of pig kidney particulate aminopeptidase
    Helv Chim Acta (1971) 54, 473-485. PubMed  Europe PubMed DOI
    277. 1970
  277. [YEAR:11-5-1970]Femfert,U. and Pfleiderer,G.
    On the mechanism of amide-bond-cleavage catalyzed by aminopeptidase M. kinetic studies
    FEBS Lett (11-5-1970) 8, 65-67. PubMed  Europe PubMed
    278. 1969
  278. Femfert,U. and Pfleiderer,G.
    The tyrosyl residues at the active site of aminopeptidase M modifications by tetranitromethane
    FEBS Lett (1969) 4, 262-264. PubMed  Europe PubMed
  279. Pfleiderer,G. and Femfert,U.
    Histidine residues at the active site of aminopeptidase M modifications by diazonium-1-h-tetrazole (dht)
    FEBS Lett (1969) 4, 265-268. PubMed  Europe PubMed  I
    280. 1967
  280. Hanson,H., Glasser,D., Ludewig,M., Mannsfeldt,H.G. and John,M.
    [Structural and activity identity of leucine aminopeptidase from pig kidney and bovine lens, and comparison with particulate aminopeptidase from pig kidney]
    Hoppe Seylers Z Physiol Chem (1967) 348, 689-704. PubMed  Europe PubMed
  281. Hanson,H., Hutter,H.J., Mannsfeldt,H.G., Kretschmer,K. and Sohr,C.
    [On the demonstration and substrate specificity of a kidney particle aminopeptidase distinguishable from leucine aminopeptidase]
    Hoppe Seylers Z Physiol Chem (1967) 348, 680-688. PubMed  Europe PubMed
  282. [YEAR:27-1-1967]Wachsmuth,E.D.
    [Studies on the structure of aminopeptidase from particles of pig kidneys]
    Biochem Z (27-1-1967) 346, 467-473. PubMed  Europe PubMed
    283. 1966
  283. Felgenhauer,K. and Glenner,G.G.
    The enzymatic hydrolysis of amino acid beta-naphthylamides. II. Partial purification and properties of a particle-bound cobalt-activated rat kidney aminopeptidase
    J Histochem Cytochem (1966) 14, 401-413. PubMed  Europe PubMed
  284. Wachsmuth,E.D., Fritze,I. and Pfleiderer,G.
    An aminopeptidase occurring in pig kidney. I. An improved method of preparation. Physical and enzymic properties
    Biochemistry (1966) 5, 169-174. PubMed  Europe PubMed
  285. [YEAR:7-6-1966]Wachsmuth,E.D.
    [Comparative studies on the action mechanism of aminopeptidases]
    Biochem Z (7-6-1966) 344, 361-374. PubMed  Europe PubMed
    286. 1964
  286. [YEAR:23-12-1964]Loughlin,R.E. and Trikojus,V.M.
    A metal-dependent peptidase from thyroid glands
    Biochim Biophys Acta (23-12-1964) 92, 529-542. PubMed  Europe PubMed
  287. [YEAR:6-11-1964]Pfleiderer,G., Celliers,P.G., Stanulovic,M., Wachsmuth,E.D., Determann,H. and Braunitzer,G.
    [Properties and analytical uses of aminopeptidase from kidney particles]
    Biochem Z (6-11-1964) 340, 552-564. PubMed  Europe PubMed
    288. 1963
  288. Patterson,E.K., Hsiao,S.H. and Keppel,A.
    Studies on dipeptidases and aminopeptidases. I. Distinction between leucine aminopeptidase and enzymes that hydrolyze l-leucyl-beta-naphthylamide
    J Biol Chem (1963) 238, 3611-3620. PubMed  Europe PubMed
  289. [YEAR:3-12-1963]Pfleiderer,G. and Celliers,P.G.
    [Isolation of an aminopeptidase from kidney particles]
    Biochem Z (3-12-1963) 339, 186-189. PubMed  Europe PubMed
    290. 1957
  290. Binkley,F., Alexander,V., Bell,F.E. and Lea,C.
    Peptidases and alkaline phosphatases of swine kidney
    J Biol Chem (1957) 228, 559-567. PubMed  Europe PubMed
  291. Semenza,G.
    Chromatographic purification of cysteinyl-glycinase
    Biochim Biophys Acta (1957) 24, 401-413. PubMed  Europe PubMed
    292. 1955
  292. Smith,E.L.
    [9] Aminopeptidases
    Methods Enzymol (1955) 2, 83-93. DOI
    293. 1951
  293. [YEAR:2-6-1951]Binkley,F.
    Metabolism of glutathione
    Nature (2-6-1951) 167, 888-889. PubMed  Europe PubMed DOI
    294. 1948
  294. Binkley,F. and Nakamura,K.
    Metabolism of glutathione. I. Hydrolysis by tissues of the rat
    J Biol Chem (1948) 173, 411-421. PubMed  Europe PubMed

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