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Literature for peptidase M01.001: aminopeptidase N

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Muraoka,S., Brodie,W.D., Mattichak,M.N., Gurrea-Rubio,M., Ikari,Y., Foster,C., Amin,M.A., Khanna,N., Amin,H., Campbell,P.L., Vichaikul,S., Model,E.N., Omara,M.M., Petrovski,S., Kozicki,K., Amarista,C., Webber,A., Ali,M., Palisoc,P.J., Hervoso,J., Ruth,J.H., Tsoi,L.C., Varga,J., Gudjonsson,J.E., Khanna,D., Fox,D.A. and Tsou,P.S.
    Targeting CD13/aminopeptidase N as a novel therapeutic approach for scleroderma fibrosis
    Arthritis Rheumatol77, 80-91. PubMed  Europe PubMed DOI
  2. Sun,X., Wang,X., Fu,L., Wang,X., Chen,L. and Huang,Y.
    Correction to "A Nanofluorescent Probe for Evaluating the Fluctuation of Aminopeptidase N in Nonalcoholic Fatty Liver Disease and Hepatic Fibrosis"
    Anal Chem PubMed  Europe PubMed DOI
  3. Tsai,Y.X., Chien,Y.C., Hsu,M.F., Khoo,K.H. and Hsu,S.D.
    Molecular basis of host recognition of human coronavirus 229E
    Nat Commun16, 2045-2045. PubMed  Europe PubMed DOI
  4. Yi,B., Yatabe,H., Sakamoto,D.M., Tamura,I., Saito,Y., Yamada,N., Ashikaga,R., Kuroda,M., Kubota,S.I., Tainaka,K. and Sando,S.
    Imaging Heterogeneous Patterns of Aminopeptidase N Activity in Hierarchical Tissue Structures Through High-resolution Whole-organ 3D Mapping
    Angew Chem Int Ed Engle202504668-e202504668. PubMed  Europe PubMed DOI
    5. 2024
  5. Anderluzzi,G., Ghitti,M., Gasparri,A.M., Taie,G., Sacchi,A., Gori,A., Andolfo,A., Pozzi,F., Musco,G., Curnis,F. and Corti,A.
    A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins
    Cell Mol Life Sci81, 68-68. PubMed  Europe PubMed DOI
    6. 2023
  6. Diaz-Alvarez,L., Martinez-Sanchez,M.E., Gray,E., Perez-Figueroa,E. and Ortega,E.
    Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18
    Biomolecules13, PubMed  Europe PubMed DOI
  7. Jia,G., Qi,K., Hou,B., Yue,K., Xu,T., Jiang,Y. and Li,X.
    Design, synthesis, and biological evaluation of novel HDAC/CD13 dual inhibitors for the treatment of cancer
    Eur J Med Chem260, 115752-115752. PubMed  Europe PubMed DOI  I
  8. Lie,L.K., Synowiec,A., Mazur,J., Rabalski,L. and Pyrc,K.
    An engineered A549 cell line expressing CD13 and TMPRSS2 is permissive to clinical isolate of human coronavirus 229E
    Virology588, 109889-109889. PubMed  Europe PubMed DOI
  9. Liu,Y., Chen,D., Wang,Y., Li,X., Qiu,Y., Zheng,M., Song,Y., Li,G., Song,C., Liu,T., Zhang,Y., Guo,J.T., Lin,H. and Zhao,X.
    Characterization of CCoV-HuPn-2018 spike protein-mediated viral entry
    J Virol97, e0060123-e0060123. PubMed  Europe PubMed DOI
    10. 2022
  10. Farsa,O., Ballayova,V., Zackova,R., Kollar,P., Kauerova,T. and Zubac,P.
    Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  11. Liu,Y., Zhao,D., Zhang,C., Fang,H., Shen,Q., Wang,Z. and Cao,J.
    Development of Hydroxamate Derivatives Containing a Pyrazoline Moiety as APN Inhibitors to Overcome Angiogenesis
    Molecules27, PubMed  Europe PubMed DOI  I
  12. Saito,Y., Yatabe,H., Tamura,I., Kondo,Y., Ishida,R., Seki,T., Hiraga,K., Eguchi,A., Takakusagi,Y., Saito,K., Oshima,N., Ishikita,H., Yamamoto,K., Krishna,M.C. and Sando,S.
    Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo
    Sci Adv8, eabj2667-eabj2667. PubMed  Europe PubMed DOI
  13. Shatizadeh Malekshahi,S., Yavarian,J. and Shafiei-Jandaghi,N.Z.
    Usage of peptidases by SARS-CoV-2 and several human coronaviruses as receptors: A mysterious story
    Biotechnol Appl Biochem69, 124-128. PubMed  Europe PubMed DOI
    14. 2021
  14. Barnieh,F.M., Loadman,P.M. and Falconer,R.A.
    Is tumour-expressed aminopeptidase N (APN/CD13) structurally and functionally unique?
    Biochim Biophys Acta Rev Cancer1876, 188641-188641. PubMed  Europe PubMed DOI
  15. Gao,M., Lv,Q.L., Zhang,H.P. and Tu,G.G.
    Synthesis and 4D-QSAR studies of alanine hydroxamic acid derivatives as aminopeptidase N inhibitors
    Med Chem17, 658-666. PubMed  Europe PubMed DOI  I
  16. Kis,A., Denes,N., Szabo,J.P., Arato,V., Beke,L., Matolay,O., Enyedi,K.N., Mehes,G., Mezo,G., Bai,P., Kertesz,I. and Trencsenyi,G.
    In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using (68)Ga-NODAGA-c(NGR) Peptide
    Biomed Res Int2021, 6642973-6642973. PubMed  Europe PubMed DOI  I
  17. Liu,Y., Xu,C., Liu,H.W., Teng,L., Huan,S., Yuan,L. and Zhang,X.B.
    Precipitated Fluorophore-Based Molecular Probe for In Situ Imaging of Aminopeptidase N in Living Cells and Tumors
    Anal Chem93, 6463-6471. PubMed  Europe PubMed DOI
  18. Wang,L.T., Rajah,A., Brown,C.M. and McCaffrey,L.
    CD13 orients the apical-basal polarity axis necessary for lumen formation
    Nat Commun12, 4697-4697. PubMed  Europe PubMed DOI
  19. Yang,Y.L., Liu,J., Wang,T.Y., Chen,M., Wang,G., Yang,Y.B., Geng,X., Sun,M.X., Meng,F., Tang,Y.D. and Feng,L.
    Aminopeptidase N is an entry co-factor triggering porcine deltacoronavirus entry via an endocytotic pathway
    J VirolJVI0094421-JVI0094421. PubMed  Europe PubMed DOI
  20. Yoshihara,M., Mizutani,S., Kato,Y., Matsumoto,K., Mizutani,E., Mizutani,H., Fujimoto,H., Osuka,S. and Kajiyama,H.
    Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles
    Int J Mol Sci22, PubMed  Europe PubMed DOI
    21. 2020
  21. Asiabi,P., Dolmans,M.M., Ambroise,J., Camboni,A. and Amorim,C.A.
    In vitro differentiation of theca cells from ovarian cells isolated from postmenopausal women
    Hum Reprod35, 2793-2807. PubMed  Europe PubMed DOI
  22. Balamurugan,T.S.T., Chen,G.Z., Kumaravel,S., Lin,C.M., Huang,S.T., Lee,Y.C., Chen,C.H. and Luo,G.R.
    Electrochemical substrate for active profiling of cellular surface leucine aminopeptidase activity and drug resistance in cancer cells
    Biosens Bioelectron150, 111948-111948. PubMed  Europe PubMed DOI  A  L
  23. Banerjee,S., Amin,S.A., Baidya,S.K., Adhikari,N. and Jha,T.
    Exploring the structural aspects of ureido-amino acid-based APN inhibitors: a validated comparative multi-QSAR modelling study
    SAR QSAR Environ Res31, 325-345. PubMed  Europe PubMed DOI  I
  24. Byrgazov,K., Anderson,C., Salzer,B., Bozsaky,E., Larsson,R., Gullbo,J., Lehner,M., Lehmann,F., Slipicevic,A., Kager,L., Fryknas,M. and Taschner-Mandl,S.
    Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
    Ther Adv Med Oncol12, 1758835920937891-1758835920937891. PubMed  Europe PubMed DOI
  25. Cao,J., Zhao,W., Zhao,C., Liu,Q., Li,S., Zhang,G., Chou,C.J. and Zhang,Y.
    Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC
    Molecules25, PubMed  Europe PubMed DOI  I
  26. Devarakonda,C.K.V., Meredith,E., Ghosh,M. and Shapiro,L.H.
    Coronavirus Receptors as Immune Modulators
    J Immunol PubMed  Europe PubMed DOI  V
  27. Dominguez-Vias,G., Aretxaga,G., Prieto,I., Segarra,A.B., Luna,J.D., Martinez-Canamero,M. and Ramirez-Sanchez,M.
    Asymmetrical influence of a standard light/dark cycle and constant light conditions on the alanyl-aminopeptidase activity of the left and right retinas in adult male rats
    Exp Eye Res108149-108149. PubMed  Europe PubMed DOI
  28. Ge,J., Wang,Z., Cheng,Y., Ren,J., Wu,B., Li,W., Wang,X., Su,X. and Liu,Z.
    Computational study of novel natural inhibitors targeting aminopeptidase N (CD13)
    Aging (Albany NY)12, 8523-8535. PubMed  Europe PubMed DOI  I
  29. Gregoriou,G.C., Patel,S.D., Winters,B.L. and Bagley,E.E.
    Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala
    Mol Pharmacol PubMed  Europe PubMed DOI  I
  30. Guo,Y., Carballar-Lejarazu,R., Sheng,L., Fang,Y., Wang,S., Liang,G., Hu,X., Wang,R., Zhang,F. and Wu,S.
    Identification and Characterization of Aminopeptidase-N as a Binding Protein for Cry3Aa in the Midgut of Monochamus alternatus (Coleoptera: Cerambycidae)
    J Econ Entomol PubMed  Europe PubMed DOI
  31. Kiehstaller,S., Ottmann,C. and Hennig,S.
    MMP activation associated Aminopeptidase N reveals a bivalent 14-3-3 binding motif
    J Biol Chem PubMed  Europe PubMed DOI
  32. Li,H., Yao,Q., Sun,W., Shao,K., Lu,Y., Chung,J., Kim,D., Fan,J., Long,S., Du,J., Li,Y., Wang,J., Yoon,J. and Peng,X.
    Aminopeptidase N activatable fluorescent probe for tracking metastatic cancer and image-guided surgery via in situ spraying
    J Am Chem Soc142, 6381-6389. PubMed  Europe PubMed DOI  L
  33. Melo,F.J., Pinto-Lopes,P., Estevinho,M.M. and Magro,F.
    The Role of Dipeptidyl Peptidase 4 as a Therapeutic Target and Serum Biomarker in Inflammatory Bowel Disease: A Systematic Review
    Inflamm Bowel Dis PubMed  Europe PubMed DOI  V
  34. Peng,J.Y., Punyadarsaniya,D., Shin,D.L., Pavasutthipaisit,S., Beineke,A., Li,G., Wu,N.H. and Herrler,G.
    The Cell Tropism of Porcine Respiratory Coronavirus for Airway Epithelial Cells Is Determined by the Expression of Porcine Aminopeptidase N
    Viruses12, PubMed  Europe PubMed DOI
  35. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.
    Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas
    Brain Res Bull168, 1-7. PubMed  Europe PubMed DOI
  36. Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E.
    Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
    Bone Joint Res9, 789-797. PubMed  Europe PubMed DOI
    37. 2019
  37. Cao,J., Zang,J., Kong,X., Zhao,C., Chen,T., Ran,Y., Dong,H., Xu,W. and Zhang,Y.
    Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II
    Bioorg Med Chem27, 978-990. PubMed  Europe PubMed DOI  I
  38. Chai,Y., Gao,Y., Xiong,H., Lv,W., Yang,G., Lu,C., Nie,J., Ma,C., Chen,Z., Ren,J. and Wang,F.
    A near-infrared fluorescent probe for monitoring leucine aminopeptidase in living cells
    Analyst144, 463-467. PubMed  Europe PubMed DOI  L
  39. Chen,J., Pan,K., Chen,Z., Li,Y., Ding,B., Han,C., Cao,Z., Bao,W. and Zhang,Y.
    Production of porcine aminopeptidase N (pAPN) site-specific edited pigs
    Anim Sci J90, 366-371. PubMed  Europe PubMed DOI  K
  40. Lee,J., Vinh,N.B., Drinkwater,N., Yang,W., Kannan Sivaraman,K., Schembri,L.S., Gazdik,M., Grin,P.M., Butler,G.S., Overall,C.M., Charman,S.A., McGowan,S. and Scammells,P.J.
    Novel human aminopeptidase N inhibitors: discovery and optimization of subsite binding interactions
    J Med Chem62, 7185-7209. PubMed  Europe PubMed DOI  I
  41. Li,H., Li,Y., Yao,Q., Fan,J., Sun,W., Long,S., Shao,K., Du,J., Wang,J. and Peng,X.
    In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe
    Chem Sci10, 1619-1625. PubMed  Europe PubMed DOI  L
  42. Liu,H., Wang,X., Yang,H., Zhao,Y., Ji,S., Ma,H., Zhou,Y., Wang,Y., Zhang,H., Jiang,W., Fang,C., Feng,L. and Wang,X.
    New method for detecting the suppressing effect of enzyme activity by aminopeptidase N inhibitor
    Chem Pharm Bull (Tokyo)67, 155-158. PubMed  Europe PubMed DOI  I
  43. Nganje,C.N., Haynes,S.A., Qabar,C.M., Lent,R.C., Bou Ghanem,E.N. and Shainheit,M.G.
    PepN is a non-essential, cell wall-localized protein that contributes to neutrophil elastase-mediated killing of Streptococcus pneumoniae
    PLoS ONE14, e0211632-e0211632. PubMed  Europe PubMed DOI
  44. Wanat,W., Talma,M., Pawelczak,M. and Kafarski,P.
    Phosphonic acid analogues of phenylglycine as inhibitors of aminopeptidases: comparison of porcine aminopeptidase N, bovine leucine aminopeptidase, tomato acidic leucine aminopeptidase and aminopeptidase from barley seeds
    Pharmaceuticals (Basel)12, 139-139. PubMed  Europe PubMed DOI  I
  45. Whitworth,K.M., Rowland,R.R.R., Petrovan,V., Sheahan,M., Cino-Ozuna,A.G., Fang,Y., Hesse,R., Mileham,A., Samuel,M.S., Wells,K.D. and Prather,R.S.
    Resistance to coronavirus infection in amino peptidase N-deficient pigs
    Transgenic Res28, 21-32. PubMed  Europe PubMed DOI  K
  46. Zhang,J., Wu,Z. and Yang,H.
    Aminopeptidase N knockout pigs are not resistant to porcine epidemic diarrhea virus infection
    Virol Sin34, 592-595. PubMed  Europe PubMed DOI  K
    47. 2018
  47. Amin,S.A., Adhikari,N. and Jha,T.
    Design of aminopeptidase N inhibitors as anti-cancer agents
    J Med Chem61, 6468-6490. PubMed  Europe PubMed DOI  I
  48. Cao,J., Zang,J., Ma,C., Li,X., Hou,J., Li,J., Huang,Y., Xu,W., Wang,B. and Zhang,Y.
    Design, synthesis, and biological evaluation of pyrazoline-based hydroxamic acid derivatives as aminopeptidase N (APN) inhibitors
    ChemMedChem13, 431-436. PubMed  Europe PubMed DOI  I
  49. Cao,J., Ma,C., Zang,J., Gao,S., Gao,Q., Kong,X., Yan,Y., Liang,X., Ding,Q., Zhao,C., Wang,B., Xu,W. and Zhang,Y.
    Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry
    Bioorg Med Chem26, 3145-3157. PubMed  Europe PubMed DOI  I
  50. Huang,S., Wu,Y., Zeng,F., Chen,J. and Wu,S.
    A turn-on fluorescence probe based on aggregation-induced emission for leucine aminopeptidase in living cells and tumor tissue
    Anal Chim Acta1031, 169-177. PubMed  Europe PubMed DOI  L
  51. Leung,L.L.K. and Morser,J.
    Carboxypeptidase B2 and carboxypeptidase N in the cross-talk between coagulation, thrombosis, inflammation and innate immunity
    J Thromb Haemost PubMed  Europe PubMed DOI
  52. Raffa,R.B., Pergolizzi JV Jr, Taylor R Jr and Ossipov,M.H.
    Indirect-acting strategy of opioid action instead of direct receptor activation: dual-acting enkephalinase inhibitors (DENKIs)
    J Clin Pharm Ther43, 443-449. PubMed  Europe PubMed DOI  I
  53. Salomon,E., Schmitt,M., Marapaka,A.K., Stamogiannos,A., Revelant,G., Schmitt,C., Alavi,S., Florent,I., Addlagatta,A., Stratikos,E., Tarnus,C. and Albrecht,S.
    Aminobenzosuberone scaffold as a modular chemical tool for the inhibition of therapeutically relevant M1 aminopeptidases
    Molecules23, PubMed  Europe PubMed DOI  I
  54. Schreiber,C.L. and Smith,B.D.
    Molecular imaging of aminopeptidase N in cancer and angiogenesis
    Contrast Media Mol Imaging2018, 5315172-5315172. PubMed  Europe PubMed DOI  L
    55. 2017
  55. Farsa,O., Kana,J., Macko,I., Zelazkova,J., Podlipna,J., Cirkva,A., Maxa,J. and Stastnv,K.
    Synthesis and aminopeptidase N inhibiting activity of 3-(nitrophenoxymethyl)-[1,3,2]dioxaborolan-2-ols and their open analogues
    Acta Pol Pharm74, 127-135. PubMed  Europe PubMed  I
  56. Feng,J., Chen,Y., Li,F., Cui,L., Shi,N., Kong,W. and Zhang,Y.
    Synthesis, characterization and in vitro evaluation of a novel glycol chitosan-EDTA conjugate to inhibit aminopeptidase-mediated degradation of thymopoietin oligopeptides
    Molecules22, PubMed  Europe PubMed DOI  I
  57. He,X., Xu,Y., Shi,W. and Ma,H.
    Ultrasensitive detection of aminopeptidase N activity in urine and cells with a ratiometric fluorescence probe
    Anal Chem89, 3217-3221. PubMed  Europe PubMed DOI  A
  58. He,X., Hu,Y., Shi,W., Li,X. and Ma,H.
    Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N
    Chem Commun (Camb)53, 9438-9441. PubMed  Europe PubMed DOI  L
  59. Jia,X., Han,Q., Wang,Z., Qian,Y., Jia,Y., Wang,W. and Hu,Z.
    Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy
    Biomater Sci5, 417-421. PubMed  Europe PubMed DOI  L
  60. Joshi,S., Chen,L., Winter,M.B., Lin,Y.L., Yang,Y., Shapovalova,M., Smith,P.M., Liu,C., Li,F. and Lebeau,A.M.
    The rational design of therapeutic peptides for aminopeptidase N using a substrate-based approach
    Sci Rep7, 1424-1424. PubMed  Europe PubMed DOI  P  I
  61. Kamau,A.N., Park,J.E., Park,E.S., Yu,J.E., Rho,J. and Shin,H.J.
    Porcine amino peptidase N domain VII has critical role in binding and entry of porcine epidemic diarrhea virus
    Virus Res227, 150-157. PubMed  Europe PubMed DOI
  62. Khatun,A., Rahman,M.S., Ryu,D.Y., Kwon,W.S. and Pang,M.G.
    Elevated aminopeptidase N affects sperm motility and early embryo development
    PLoS ONE12, e0184294-e0184294. PubMed  Europe PubMed DOI  E
  63. Pascual,I., Valiente,P.A., Garcia,G., Valdes-Tresanco,M.E., Arrebola,Y., Diaz,L., Bounaadja,L., Uribe,R.M., Pacheco,M.C., Florent,I. and Charli,J.L.
    Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN)
    Biochimie142, 216-225. PubMed  Europe PubMed DOI  I
  64. Santiago,C., Mudgal,G., Reguera,J., Recacha,R., Albrecht,S., Enjuanes,L. and Casasnovas,J.M.
    Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection
    Sci Rep7, 46045-46045. PubMed  Europe PubMed DOI  S
  65. Zhang,W., Liu,F., Zhang,C., Luo,J.G., Luo,J., Yu,W. and Kong,L.
    Near-infrared fluorescent probe with remarkable large Stokes shift and favorable water solubility for real-time tracking leucine aminopeptidase in living cells and in vivo
    Anal Chem89, 12319-12326. PubMed  Europe PubMed DOI  A
  66. Zhou,Z., Wang,F., Yang,G., Lu,C., Nie,J., Chen,Z., Ren,J., Sun,Q., Zhao,C. and Zhu,W.H.
    A ratiometric fluorescent probe for monitoring leucine aminopeptidase in living cells and zebrafish model
    Anal Chem89, 11576-11582. PubMed  Europe PubMed DOI  A
    67. 2016
  67. Cui,R., Zhang,P. and Li,Y.
    Role of carboxypeptidase N invasion and migration in breast cancer
    Anticancer Agents Med Chem16, 1198-1202. PubMed  Europe PubMed  K
  68. Fiddler,C.A., Parfrey,H., Cowburn,A.S., Luo,D., Nash,G.B., Murphy,G. and Chilvers,E.R.
    The aminopeptidase CD13 induces homotypic aggregation in neutrophils and impairs collagen invasion
    PLoS ONE11, e0160108-e0160108. PubMed  Europe PubMed DOI
  69. Gong,Q., Shi,W., Li,L. and Ma,H.
    Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe
    Chem Sci7, 788-792. PubMed  Europe PubMed DOI  A  L
  70. Hata,R., Nonaka,H., Takakusagi,Y., Ichikawa,K. and Sando,S.
    Design of a hyperpolarized molecular probe for detection of aminopeptidase N activity
    Angew Chem Int Ed Engl55, 1765-1768. PubMed  Europe PubMed DOI  A
  71. Hou,J., Jin,K., Li,J., Jiang,Y., Li,X., Wang,X., Huang,Y., Zhang,Y. and Xu,W.
    LJNK, an indoline-2,3-dione-based aminopeptidase N inhibitor with promising antitumor potency
    Anticancer Drugs27, 496-507. PubMed  Europe PubMed DOI  I
  72. Ma,C., Cao,J., Liang,X., Huang,Y., Wu,P., Li,Y., Xu,W. and Zhang,Y.
    Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation
    Eur J Med Chem108, 21-27. PubMed  Europe PubMed DOI  I
  73. Shibata,M., Koike,M., Kusumi,S., Sato,N. and Uchiyama,Y.
    A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney
    Arch Histol Cytol76, 1-8. DOI
  74. Tang,J., Qu,F., Tang,X., Zhao,Q., Wang,Y., Zhou,Y., Feng,J., Lu,S., Hou,D. and Liu,Z.
    Molecular characterization and dietary regulation of aminopeptidase N (APN) in the grass carp (Ctenopharyngodon idella)
    Gene582, 77-84. PubMed  Europe PubMed DOI
    75. 2015
  75. Akita,S., Hattori,N., Masuda,T., Horimasu,Y., Nakashima,T., Iwamoto,H., Fujitaka,K., Miyake,M. and Kohno,N.
    MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model
    Cancer Sci106, 921-928. PubMed  Europe PubMed DOI
  76. Bonnard,E., Poras,H., Nadal,X., Maldonado,R., Fournie-Zaluski,M.C. and Roques,B.P.
    Long-lasting oral analgesic effects of N-protected aminophosphinic dual enkephalinase inhibitors (DENKIs) in peripherally controlled pain
    Pharmacol Res Perspect3, e00116-e00116. PubMed  Europe PubMed DOI  I
  77. Chen,H., Wang,H., Qin,X.-J., Chen,C., Feng,L., Chen,L.-Z., Du,L.-P. and Li,M.-Y.
    A bestatin-based fluorescent probe for aminopeptidase N cell imaging
    Chin Chem Lett26, 513-516. DOI  L  I
  78. Poras,H., Bonnard,E., Fournie-Zaluski,M.C. and Roques,B.P.
    Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route
    Eur J Med Chem102, 58-67. PubMed  Europe PubMed DOI  I
  79. Revelant,G., Al-Lakkis-Wehbe,M., Schmitt,M., Alavi,S., Schmitt,C., Roux,L., Al-Masri,M., Schifano-Faux,N., Maiereanu,C., Tarnus,C. and Albrecht,S.
    Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors
    Bioorg Med Chem23, 3192-3207. PubMed  Europe PubMed DOI  I
  80. Sun,Z.P., Zhang,J., Shi,L.H., Zhang,X.R., Duan,Y., Xu,W.F., Dai,G. and Wang,X.J.
    Aminopeptidase N inhibitor 4cc synergizes antitumor effects of 5-fluorouracil on human liver cancer cells through ROS-dependent CD13 inhibition
    Biomed Pharmacother76, 65-72. PubMed  Europe PubMed DOI  I
  81. Tang,X., Qu,Q., Kuang,B., Li,S. and Tu,G.
    3D-QSAR studies on flavone-8-acetic acid derivatives of aminopeptidase N inhibitors
    Med Chem11, 764-770. PubMed  Europe PubMed  I
  82. Wang,H., Xu,W., Cao,J. and Wang,W.
    Rapid screening of aminopeptidase N inhibitors by capillary electrophoresis with electrophoretically mediated microanalysis
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