Literature for peptidase M01.001: aminopeptidase N

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Wen,D.K., Fan,L., Zhou,J.L. and Wang,K. An activatable Hemicyanine-based fluorescent probe for specific detection and imaging of aminopeptidase N in diabetic wound healing Spectrochim Acta A Mol Biomol Spectrosc (2026) 345, 126848-126848. PubMed Europe PubMed DOI

2025

An,D., Li,Y., Pei,Y., Ma,Y.H., Yao,F., Feng,Y., Shan,Y. and Liu,F. Resolving the APN controversy in PEDV infection: Comparative kinetic characterization through single-virus tracking PLoS Pathog (2025) 21, e1013317-e1013317. PubMed Europe PubMed DOI PMC EPMC
Farsa,O. and Uher,T. Aminopeptidase N: a multifunctional and promising target in medicinal chemistry RSC Adv (2025) 15, 26455-26472. PubMed Europe PubMed DOI PMC EPMC
Jin,M., Jefferson,V.A., Zhao,Z., Catanzaro,N.J., De Sabato,L., Keller,E.L., Menasche,B.L., Hoffman,C., Castelli,A., Di Bartolo,I., Vaccari,G., Starr,T.N., Seifert,S.N., Castellanos,A.A., Han,B.A., Serebryannyy,L., Spaulding,A.B., Douek,D.C., Moreno,A., Baric,R.S., Wilen,C.B., Rini,J.M. and Letko,M. Aminopeptidase N is a receptor for hedgehog merbecoviruses bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Lean,F.Z.X., Gallo,G., Newman,J., Ackroyd,S., Spiro,S., Cox,R., Nymo,I.H., Brojer,C., Neimanis,A., Suarez-Bonnet,A., Priestnall,S.L., Everest,H., Keep,S., Bailey,D., Delahay,R.J., Seekings,A.H., McElhinney,L.M., Brookes,S.M. and Nunez,A. Distribution of aminopeptidase N coronavirus receptors in the respiratory and digestive tracts of domestic and wild artiodactyls and carnivores J Gen Virol (2025) 106 PubMed Europe PubMed DOI PMC EPMC
Muraoka,S., Brodie,W.D., Mattichak,M.N., Gurrea-Rubio,M., Ikari,Y., Foster,C., Amin,M.A., Khanna,N., Amin,H., Campbell,P.L., Vichaikul,S., Model,E.N., Omara,M.M., Petrovski,S., Kozicki,K., Amarista,C., Webber,A., Ali,M., Palisoc,P.J., Hervoso,J., Ruth,J.H., Tsoi,L.C., Varga,J., Gudjonsson,J.E., Khanna,D., Fox,D.A. and Tsou,P.S. Targeting CD13/aminopeptidase N as a novel therapeutic approach for scleroderma fibrosis Arthritis Rheumatol (2025) 77, 80-91. PubMed Europe PubMed DOI
Sun,X., Wang,X., Fu,L., Wang,X., Chen,L. and Huang,Y. Correction to "A Nanofluorescent Probe for Evaluating the Fluctuation of Aminopeptidase N in Nonalcoholic Fatty Liver Disease and Hepatic Fibrosis" Anal Chem (2025) PubMed Europe PubMed DOI
Tsai,Y.X., Chien,Y.C., Hsu,M.F., Khoo,K.H. and Hsu,S.D. Molecular basis of host recognition of human coronavirus 229E Nat Commun (2025) 16, 2045-2045. PubMed Europe PubMed DOI PMC EPMC
Yi,B., Yatabe,H., Sakamoto,D.M., Tamura,I., Saito,Y., Yamada,N., Ashikaga,R., Kuroda,M., Kubota,S.I., Tainaka,K. and Sando,S. Imaging Heterogeneous Patterns of Aminopeptidase N Activity in Hierarchical Tissue Structures Through High-resolution Whole-organ 3D Mapping Angew Chem Int Ed Engl (2025) , e202504668-e202504668. PubMed Europe PubMed DOI
Zhang,Y.Q., Wang,B., Yang,Y.L., Meng,J.X., Zhang,M.D., Li,Y.K., Dong,B., Zhang,Y., Liu,B.W., Yang,D., Ji,C.M., Huang,Y.W. and Zhu,S.J. A gut microbiota-bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N Imeta (2025) 4, e70061-e70061. PubMed Europe PubMed DOI PMC EPMC

2024

Anderluzzi,G., Ghitti,M., Gasparri,A.M., Taie,G., Sacchi,A., Gori,A., Andolfo,A., Pozzi,F., Musco,G., Curnis,F. and Corti,A. A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins Cell Mol Life Sci (2024) 81, 68-68. PubMed Europe PubMed DOI PMC EPMC
Liang,W., Feng,R., Li,X., Duan,X., Feng,S., Chen,J., Li,Y., Chen,J., Liu,Z., Wang,X., Ruan,G., Tang,S., Ding,C., Huang,B., Zou,Z. and Chen,T. A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression Nat Commun (2024) 15, 8792-8792. PubMed Europe PubMed DOI PMC EPMC

2023

Diaz-Alvarez,L., Martinez-Sanchez,M.E., Gray,E., Perez-Figueroa,E. and Ortega,E. Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18 Biomolecules (2023) 13 PubMed Europe PubMed DOI PMC EPMC
Jia,G., Qi,K., Hou,B., Yue,K., Xu,T., Jiang,Y. and Li,X. Design, synthesis, and biological evaluation of novel HDAC/CD13 dual inhibitors for the treatment of cancer Eur J Med Chem (2023) 260, 115752-115752. PubMed Europe PubMed DOI I
Lie,L.K., Synowiec,A., Mazur,J., Rabalski,L. and Pyrc,K. An engineered A549 cell line expressing CD13 and TMPRSS2 is permissive to clinical isolate of human coronavirus 229E Virology (2023) 588, 109889-109889. PubMed Europe PubMed DOI
Liu,Y., Chen,D., Wang,Y., Li,X., Qiu,Y., Zheng,M., Song,Y., Li,G., Song,C., Liu,T., Zhang,Y., Guo,J.T., Lin,H. and Zhao,X. Characterization of CCoV-HuPn-2018 spike protein-mediated viral entry J Virol (2023) 97, e0060123-e0060123. PubMed Europe PubMed DOI PMC EPMC

2022

Farsa,O., Ballayova,V., Zackova,R., Kollar,P., Kauerova,T. and Zubac,P. Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Liu,Y., Zhao,D., Zhang,C., Fang,H., Shen,Q., Wang,Z. and Cao,J. Development of Hydroxamate Derivatives Containing a Pyrazoline Moiety as APN Inhibitors to Overcome Angiogenesis Molecules (2022) 27 PubMed Europe PubMed DOI PMC EPMC I
Saito,Y., Yatabe,H., Tamura,I., Kondo,Y., Ishida,R., Seki,T., Hiraga,K., Eguchi,A., Takakusagi,Y., Saito,K., Oshima,N., Ishikita,H., Yamamoto,K., Krishna,M.C. and Sando,S. Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo Sci Adv (2022) 8, eabj2667-eabj2667. PubMed Europe PubMed DOI PMC EPMC
Shatizadeh Malekshahi,S., Yavarian,J. and Shafiei-Jandaghi,N.Z. Usage of peptidases by SARS-CoV-2 and several human coronaviruses as receptors: A mysterious story Biotechnol Appl Biochem (2022) 69, 124-128. PubMed Europe PubMed DOI

2021

Barnieh,F.M., Loadman,P.M. and Falconer,R.A. Is tumour-expressed aminopeptidase N (APN/CD13) structurally and functionally unique? Biochim Biophys Acta Rev Cancer (2021) 1876, 188641-188641. PubMed Europe PubMed DOI
Gao,M., Lv,Q.L., Zhang,H.P. and Tu,G.G. Synthesis and 4D-QSAR studies of alanine hydroxamic acid derivatives as aminopeptidase N inhibitors Med Chem (2021) 17, 658-666. PubMed Europe PubMed DOI I
Kis,A., Denes,N., Szabo,J.P., Arato,V., Beke,L., Matolay,O., Enyedi,K.N., Mehes,G., Mezo,G., Bai,P., Kertesz,I. and Trencsenyi,G. In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using (68)Ga-NODAGA-c(NGR) Peptide Biomed Res Int (2021) 2021, 6642973-6642973. PubMed Europe PubMed DOI PMC EPMC I
Liu,Y., Xu,C., Liu,H.W., Teng,L., Huan,S., Yuan,L. and Zhang,X.B. Precipitated Fluorophore-Based Molecular Probe for In Situ Imaging of Aminopeptidase N in Living Cells and Tumors Anal Chem (2021) 93, 6463-6471. PubMed Europe PubMed DOI
Wang,L.T., Rajah,A., Brown,C.M. and McCaffrey,L. CD13 orients the apical-basal polarity axis necessary for lumen formation Nat Commun (2021) 12, 4697-4697. PubMed Europe PubMed DOI PMC EPMC
Yang,Y.L., Liu,J., Wang,T.Y., Chen,M., Wang,G., Yang,Y.B., Geng,X., Sun,M.X., Meng,F., Tang,Y.D. and Feng,L. Aminopeptidase N is an entry co-factor triggering porcine deltacoronavirus entry via an endocytotic pathway J Virol (2021) , JVI0094421-JVI0094421. PubMed Europe PubMed DOI
Yoshihara,M., Mizutani,S., Kato,Y., Matsumoto,K., Mizutani,E., Mizutani,H., Fujimoto,H., Osuka,S. and Kajiyama,H. Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC

2020

Asiabi,P., Dolmans,M.M., Ambroise,J., Camboni,A. and Amorim,C.A. In vitro differentiation of theca cells from ovarian cells isolated from postmenopausal women Hum Reprod (2020) 35, 2793-2807. PubMed Europe PubMed DOI
Balamurugan,T.S.T., Chen,G.Z., Kumaravel,S., Lin,C.M., Huang,S.T., Lee,Y.C., Chen,C.H. and Luo,G.R. Electrochemical substrate for active profiling of cellular surface leucine aminopeptidase activity and drug resistance in cancer cells Biosens Bioelectron (2020) 150, 111948-111948. PubMed Europe PubMed DOI A L
Banerjee,S., Amin,S.A., Baidya,S.K., Adhikari,N. and Jha,T. Exploring the structural aspects of ureido-amino acid-based APN inhibitors: a validated comparative multi-QSAR modelling study SAR QSAR Environ Res (2020) 31, 325-345. PubMed Europe PubMed DOI I
Byrgazov,K., Anderson,C., Salzer,B., Bozsaky,E., Larsson,R., Gullbo,J., Lehner,M., Lehmann,F., Slipicevic,A., Kager,L., Fryknas,M. and Taschner-Mandl,S. Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide Ther Adv Med Oncol (2020) 12, 1758835920937891-1758835920937891. PubMed Europe PubMed DOI PMC EPMC
Cao,J., Zhao,W., Zhao,C., Liu,Q., Li,S., Zhang,G., Chou,C.J. and Zhang,Y. Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC Molecules (2020) 25 PubMed Europe PubMed DOI PMC EPMC I
Cheng,Y.C., Ku,W.C., Tseng,T.T., Wu,C.P., Li,M. and Lee,S.C. Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin beta4 axis Aging (Albany NY) (2020) 12 PubMed Europe PubMed DOI
Devarakonda,C.K.V., Meredith,E., Ghosh,M. and Shapiro,L.H. Coronavirus Receptors as Immune Modulators J Immunol (2020) PubMed Europe PubMed DOI V
Dominguez-Vias,G., Aretxaga,G., Prieto,I., Segarra,A.B., Luna,J.D., Martinez-Canamero,M. and Ramirez-Sanchez,M. Asymmetrical influence of a standard light/dark cycle and constant light conditions on the alanyl-aminopeptidase activity of the left and right retinas in adult male rats Exp Eye Res (2020) , 108149-108149. PubMed Europe PubMed DOI
Ge,J., Wang,Z., Cheng,Y., Ren,J., Wu,B., Li,W., Wang,X., Su,X. and Liu,Z. Computational study of novel natural inhibitors targeting aminopeptidase N (CD13) Aging (Albany NY) (2020) 12, 8523-8535. PubMed Europe PubMed DOI I
Gregoriou,G.C., Patel,S.D., Winters,B.L. and Bagley,E.E. Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala Mol Pharmacol (2020) PubMed Europe PubMed DOI I
Guo,Y., Carballar-Lejarazu,R., Sheng,L., Fang,Y., Wang,S., Liang,G., Hu,X., Wang,R., Zhang,F. and Wu,S. Identification and Characterization of Aminopeptidase-N as a Binding Protein for Cry3Aa in the Midgut of Monochamus alternatus (Coleoptera: Cerambycidae) J Econ Entomol (2020) PubMed Europe PubMed DOI
Kiehstaller,S., Ottmann,C. and Hennig,S. MMP activation associated Aminopeptidase N reveals a bivalent 14-3-3 binding motif J Biol Chem (2020) PubMed Europe PubMed DOI
Li,H., Yao,Q., Sun,W., Shao,K., Lu,Y., Chung,J., Kim,D., Fan,J., Long,S., Du,J., Li,Y., Wang,J., Yoon,J. and Peng,X. Aminopeptidase N activatable fluorescent probe for tracking metastatic cancer and image-guided surgery via in situ spraying J Am Chem Soc (2020) 142, 6381-6389. PubMed Europe PubMed DOI L
Melo,F.J., Pinto-Lopes,P., Estevinho,M.M. and Magro,F. The Role of Dipeptidyl Peptidase 4 as a Therapeutic Target and Serum Biomarker in Inflammatory Bowel Disease: A Systematic Review Inflamm Bowel Dis (2020) PubMed Europe PubMed DOI V
Peng,J.Y., Punyadarsaniya,D., Shin,D.L., Pavasutthipaisit,S., Beineke,A., Li,G., Wu,N.H. and Herrler,G. The Cell Tropism of Porcine Respiratory Coronavirus for Airway Epithelial Cells Is Determined by the Expression of Porcine Aminopeptidase N Viruses (2020) 12 PubMed Europe PubMed DOI
Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M. Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas Brain Res Bull (2020) 168, 1-7. PubMed Europe PubMed DOI
Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E. Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression Bone Joint Res (2020) 9, 789-797. PubMed Europe PubMed DOI PMC EPMC

2019

Cao,J., Zang,J., Kong,X., Zhao,C., Chen,T., Ran,Y., Dong,H., Xu,W. and Zhang,Y. Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II Bioorg Med Chem (2019) 27, 978-990. PubMed Europe PubMed DOI I
Chai,Y., Gao,Y., Xiong,H., Lv,W., Yang,G., Lu,C., Nie,J., Ma,C., Chen,Z., Ren,J. and Wang,F. A near-infrared fluorescent probe for monitoring leucine aminopeptidase in living cells Analyst (2019) 144, 463-467. PubMed Europe PubMed DOI L
Chen,J., Pan,K., Chen,Z., Li,Y., Ding,B., Han,C., Cao,Z., Bao,W. and Zhang,Y. Production of porcine aminopeptidase N (pAPN) site-specific edited pigs Anim Sci J (2019) 90, 366-371. PubMed Europe PubMed DOI K
Lee,J., Vinh,N.B., Drinkwater,N., Yang,W., Kannan Sivaraman,K., Schembri,L.S., Gazdik,M., Grin,P.M., Butler,G.S., Overall,C.M., Charman,S.A., McGowan,S. and Scammells,P.J. Novel human aminopeptidase N inhibitors: discovery and optimization of subsite binding interactions J Med Chem (2019) 62, 7185-7209. PubMed Europe PubMed DOI I
Li,H., Li,Y., Yao,Q., Fan,J., Sun,W., Long,S., Shao,K., Du,J., Wang,J. and Peng,X. In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe Chem Sci (2019) 10, 1619-1625. PubMed Europe PubMed DOI PMC EPMC L
Liu,H., Wang,X., Yang,H., Zhao,Y., Ji,S., Ma,H., Zhou,Y., Wang,Y., Zhang,H., Jiang,W., Fang,C., Feng,L. and Wang,X. New method for detecting the suppressing effect of enzyme activity by aminopeptidase N inhibitor Chem Pharm Bull (Tokyo) (2019) 67, 155-158. PubMed Europe PubMed DOI I
Nganje,C.N., Haynes,S.A., Qabar,C.M., Lent,R.C., Bou Ghanem,E.N. and Shainheit,M.G. PepN is a non-essential, cell wall-localized protein that contributes to neutrophil elastase-mediated killing of Streptococcus pneumoniae PLoS ONE (2019) 14, e0211632-e0211632. PubMed Europe PubMed DOI
Wanat,W., Talma,M., Pawelczak,M. and Kafarski,P. Phosphonic acid analogues of phenylglycine as inhibitors of aminopeptidases: comparison of porcine aminopeptidase N, bovine leucine aminopeptidase, tomato acidic leucine aminopeptidase and aminopeptidase from barley seeds Pharmaceuticals (Basel) (2019) 12, 139-139. PubMed Europe PubMed DOI I
Whitworth,K.M., Rowland,R.R.R., Petrovan,V., Sheahan,M., Cino-Ozuna,A.G., Fang,Y., Hesse,R., Mileham,A., Samuel,M.S., Wells,K.D. and Prather,R.S. Resistance to coronavirus infection in amino peptidase N-deficient pigs Transgenic Res (2019) 28, 21-32. PubMed Europe PubMed DOI K
Zhang,J., Wu,Z. and Yang,H. Aminopeptidase N knockout pigs are not resistant to porcine epidemic diarrhea virus infection Virol Sin (2019) 34, 592-595. PubMed Europe PubMed DOI K

2018

Amin,S.A., Adhikari,N. and Jha,T. Design of aminopeptidase N inhibitors as anti-cancer agents J Med Chem (2018) 61, 6468-6490. PubMed Europe PubMed DOI I
Cao,J., Zang,J., Ma,C., Li,X., Hou,J., Li,J., Huang,Y., Xu,W., Wang,B. and Zhang,Y. Design, synthesis, and biological evaluation of pyrazoline-based hydroxamic acid derivatives as aminopeptidase N (APN) inhibitors ChemMedChem (2018) 13, 431-436. PubMed Europe PubMed DOI I
Cao,J., Ma,C., Zang,J., Gao,S., Gao,Q., Kong,X., Yan,Y., Liang,X., Ding,Q., Zhao,C., Wang,B., Xu,W. and Zhang,Y. Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry Bioorg Med Chem (2018) 26, 3145-3157. PubMed Europe PubMed DOI I
Huang,S., Wu,Y., Zeng,F., Chen,J. and Wu,S. A turn-on fluorescence probe based on aggregation-induced emission for leucine aminopeptidase in living cells and tumor tissue Anal Chim Acta (2018) 1031, 169-177. PubMed Europe PubMed DOI L
Leung,L.L.K. and Morser,J. Carboxypeptidase B2 and carboxypeptidase N in the cross-talk between coagulation, thrombosis, inflammation and innate immunity J Thromb Haemost (2018) PubMed Europe PubMed DOI
Raffa,R.B., Pergolizzi JV Jr, Taylor R Jr and Ossipov,M.H. Indirect-acting strategy of opioid action instead of direct receptor activation: dual-acting enkephalinase inhibitors (DENKIs) J Clin Pharm Ther (2018) 43, 443-449. PubMed Europe PubMed DOI I
Salomon,E., Schmitt,M., Marapaka,A.K., Stamogiannos,A., Revelant,G., Schmitt,C., Alavi,S., Florent,I., Addlagatta,A., Stratikos,E., Tarnus,C. and Albrecht,S. Aminobenzosuberone scaffold as a modular chemical tool for the inhibition of therapeutically relevant M1 aminopeptidases Molecules (2018) 23 PubMed Europe PubMed DOI I
Schreiber,C.L. and Smith,B.D. Molecular imaging of aminopeptidase N in cancer and angiogenesis Contrast Media Mol Imaging (2018) 2018, 5315172-5315172. PubMed Europe PubMed DOI PMC EPMC L

2017

Farsa,O., Kana,J., Macko,I., Zelazkova,J., Podlipna,J., Cirkva,A., Maxa,J. and Stastnv,K. Synthesis and aminopeptidase N inhibiting activity of 3-(nitrophenoxymethyl)-[1,3,2]dioxaborolan-2-ols and their open analogues Acta Pol Pharm (2017) 74, 127-135. PubMed Europe PubMed I
Feng,J., Chen,Y., Li,F., Cui,L., Shi,N., Kong,W. and Zhang,Y. Synthesis, characterization and in vitro evaluation of a novel glycol chitosan-EDTA conjugate to inhibit aminopeptidase-mediated degradation of thymopoietin oligopeptides Molecules (2017) 22 PubMed Europe PubMed DOI I
He,X., Xu,Y., Shi,W. and Ma,H. Ultrasensitive detection of aminopeptidase N activity in urine and cells with a ratiometric fluorescence probe Anal Chem (2017) 89, 3217-3221. PubMed Europe PubMed DOI A
He,X., Hu,Y., Shi,W., Li,X. and Ma,H. Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N Chem Commun (Camb) (2017) 53, 9438-9441. PubMed Europe PubMed DOI L
Jia,X., Han,Q., Wang,Z., Qian,Y., Jia,Y., Wang,W. and Hu,Z. Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy Biomater Sci (2017) 5, 417-421. PubMed Europe PubMed DOI L
Joshi,S., Chen,L., Winter,M.B., Lin,Y.L., Yang,Y., Shapovalova,M., Smith,P.M., Liu,C., Li,F. and Lebeau,A.M. The rational design of therapeutic peptides for aminopeptidase N using a substrate-based approach Sci Rep (2017) 7, 1424-1424. PubMed Europe PubMed DOI P I
Kamau,A.N., Park,J.E., Park,E.S., Yu,J.E., Rho,J. and Shin,H.J. Porcine amino peptidase N domain VII has critical role in binding and entry of porcine epidemic diarrhea virus Virus Res (2017) 227, 150-157. PubMed Europe PubMed DOI
Khatun,A., Rahman,M.S., Ryu,D.Y., Kwon,W.S. and Pang,M.G. Elevated aminopeptidase N affects sperm motility and early embryo development PLoS ONE (2017) 12, e0184294-e0184294. PubMed Europe PubMed DOI E
Pascual,I., Valiente,P.A., Garcia,G., Valdes-Tresanco,M.E., Arrebola,Y., Diaz,L., Bounaadja,L., Uribe,R.M., Pacheco,M.C., Florent,I. and Charli,J.L. Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN) Biochimie (2017) 142, 216-225. PubMed Europe PubMed DOI I
Santiago,C., Mudgal,G., Reguera,J., Recacha,R., Albrecht,S., Enjuanes,L. and Casasnovas,J.M. Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection Sci Rep (2017) 7, 46045-46045. PubMed Europe PubMed DOI PMC EPMC S
Zhang,W., Liu,F., Zhang,C., Luo,J.G., Luo,J., Yu,W. and Kong,L. Near-infrared fluorescent probe with remarkable large Stokes shift and favorable water solubility for real-time tracking leucine aminopeptidase in living cells and in vivo Anal Chem (2017) 89, 12319-12326. PubMed Europe PubMed DOI A
Zhou,Z., Wang,F., Yang,G., Lu,C., Nie,J., Chen,Z., Ren,J., Sun,Q., Zhao,C. and Zhu,W.H. A ratiometric fluorescent probe for monitoring leucine aminopeptidase in living cells and zebrafish model Anal Chem (2017) 89, 11576-11582. PubMed Europe PubMed DOI A

2016

Cui,R., Zhang,P. and Li,Y. Role of carboxypeptidase N invasion and migration in breast cancer Anticancer Agents Med Chem (2016) 16, 1198-1202. PubMed Europe PubMed K
Fiddler,C.A., Parfrey,H., Cowburn,A.S., Luo,D., Nash,G.B., Murphy,G. and Chilvers,E.R. The aminopeptidase CD13 induces homotypic aggregation in neutrophils and impairs collagen invasion PLoS ONE (2016) 11, e0160108-e0160108. PubMed Europe PubMed DOI
Gong,Q., Shi,W., Li,L. and Ma,H. Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe Chem Sci (2016) 7, 788-792. PubMed Europe PubMed DOI PMC EPMC A L
Hata,R., Nonaka,H., Takakusagi,Y., Ichikawa,K. and Sando,S. Design of a hyperpolarized molecular probe for detection of aminopeptidase N activity Angew Chem Int Ed Engl (2016) 55, 1765-1768. PubMed Europe PubMed DOI A
Hou,J., Jin,K., Li,J., Jiang,Y., Li,X., Wang,X., Huang,Y., Zhang,Y. and Xu,W. LJNK, an indoline-2,3-dione-based aminopeptidase N inhibitor with promising antitumor potency Anticancer Drugs (2016) 27, 496-507. PubMed Europe PubMed DOI I
Ma,C., Cao,J., Liang,X., Huang,Y., Wu,P., Li,Y., Xu,W. and Zhang,Y. Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation Eur J Med Chem (2016) 108, 21-27. PubMed Europe PubMed DOI I
Shibata,M., Koike,M., Kusumi,S., Sato,N. and Uchiyama,Y. A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney Arch Histol Cytol (2016) 76, 1-8. DOI
Tang,J., Qu,F., Tang,X., Zhao,Q., Wang,Y., Zhou,Y., Feng,J., Lu,S., Hou,D. and Liu,Z. Molecular characterization and dietary regulation of aminopeptidase N (APN) in the grass carp (Ctenopharyngodon idella) Gene (2016) 582, 77-84. PubMed Europe PubMed DOI

2015

Akita,S., Hattori,N., Masuda,T., Horimasu,Y., Nakashima,T., Iwamoto,H., Fujitaka,K., Miyake,M. and Kohno,N. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model Cancer Sci (2015) 106, 921-928. PubMed Europe PubMed DOI
Bonnard,E., Poras,H., Nadal,X., Maldonado,R., Fournie-Zaluski,M.C. and Roques,B.P. Long-lasting oral analgesic effects of N-protected aminophosphinic dual enkephalinase inhibitors (DENKIs) in peripherally controlled pain Pharmacol Res Perspect (2015) 3, e00116-e00116. PubMed Europe PubMed DOI PMC EPMC I
Chen,H., Wang,H., Qin,X.-J., Chen,C., Feng,L., Chen,L.-Z., Du,L.-P. and Li,M.-Y. A bestatin-based fluorescent probe for aminopeptidase N cell imaging Chin Chem Lett (2015) 26, 513-516. DOI L I
Poras,H., Bonnard,E., Fournie-Zaluski,M.C. and Roques,B.P. Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route Eur J Med Chem (2015) 102, 58-67. PubMed Europe PubMed DOI I
Revelant,G., Al-Lakkis-Wehbe,M., Schmitt,M., Alavi,S., Schmitt,C., Roux,L., Al-Masri,M., Schifano-Faux,N., Maiereanu,C., Tarnus,C. and Albrecht,S. Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors Bioorg Med Chem (2015) 23, 3192-3207. PubMed Europe PubMed DOI I
Sun,Z.P., Zhang,J., Shi,L.H., Zhang,X.R., Duan,Y., Xu,W.F., Dai,G. and Wang,X.J. Aminopeptidase N inhibitor 4cc synergizes antitumor effects of 5-fluorouracil on human liver cancer cells through ROS-dependent CD13 inhibition Biomed Pharmacother (2015) 76, 65-72. PubMed Europe PubMed DOI I
Tang,X., Qu,Q., Kuang,B., Li,S. and Tu,G. 3D-QSAR studies on flavone-8-acetic acid derivatives of aminopeptidase N inhibitors Med Chem (2015) 11, 764-770. PubMed Europe PubMed I
Wang,H., Xu,W., Cao,J. and Wang,W. Rapid screening of aminopeptidase N inhibitors by capillary electrophoresis with electrophoretically mediated microanalysis Electrophoresis (2015) 36, 319-325. PubMed Europe PubMed DOI I

2014

Cui,D.X., Wang,X.J., Zhang,X.R., Zhao,T.K., Guo,X.X., Liu,S.M., Wang,B., Ma,W.Q. and Gao,Z.Q. Preliminary detection of the anti-tumour activity of indoline-2,3-dione derivative DH-12a targeting aminopeptidase N Mol Med Rep (2014) 10, 2681-2688. PubMed Europe PubMed DOI I
Cui,S.X., Zhang,H.L., Xu,W.F. and Qu,X.J. 13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting aminopeptidase N (APN/CD13) Eur J Pharmacol (2014) 734, 50-59. PubMed Europe PubMed DOI
Hitzerd,S.M., Verbrugge,S.E., Ossenkoppele,G., Jansen,G. and Peters,G.J. Positioning of aminopeptidase inhibitors in next generation cancer therapy Amino Acids (2014) 46, 793-808. PubMed Europe PubMed DOI I
Li,J., Chen,L., Wu,W., Zhang,W., Ma,Z., Cheng,Y., Du,L. and Li,M. Discovery of bioluminogenic probes for aminopeptidase N imaging Anal Chem (2014) 86, 2747-2751. PubMed Europe PubMed DOI L
Liu,C., Yang,Y., Chen,L., Lin,Y.L. and Li,F. A unified mechanism for aminopeptidase N-based tumor cell motility and tumor-homing therapy J Biol Chem (2014) 289, 34520-34529. PubMed Europe PubMed DOI S
Poras,H., Bonnard,E., Dange,E., Fournie-Zaluski,M.C. and Roques,B.P. New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment J Med Chem (2014) 57, 5748-5763. PubMed Europe PubMed DOI I

2013

Chen,L., Sun,W., Li,J., Liu,Z., Ma,Z., Zhang,W., Du,L., Xu,W., Fang,H. and Li,M. The first ratiometric fluorescent probes for aminopeptidase N cell imaging Org Biomol Chem (2013) 11, 378-382. PubMed Europe PubMed DOI A L
Chen,L.Z., Du,L.P. and Li,M.Y. The first inhibitor-based fluorescent imaging probe for aminopeptidase N Drug Discov Ther (2013) 7, 124-125. PubMed Europe PubMed I
Hahnenkamp,A., Schafers,M., Bremer,C. and Holtke,C. Design and synthesis of small-molecule fluorescent photoprobes targeted to aminopeptdase N (APN/CD13) for optical imaging of angiogenesis Bioconjug Chem (2013) 24, 1027-1038. PubMed Europe PubMed DOI L I
Halder,A.K., Saha,A. and Jha,T. Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors Mol Divers (2013) 17, 123-137. PubMed Europe PubMed DOI I
Hu,Z., Yang,W., Ma,X., Ma,W., Qu,X., Liang,J., Wang,J. and Tian,J. Cerenkov luminescence tomography of aminopeptidase N (APN/CD13) expression in mice bearing HT1080 tumors Mol Imaging (2013) 12, 173-181. PubMed Europe PubMed L
Jin,K., Zhang,X., Ma,C., Xu,Y., Yuan,Y. and Xu,W. Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN) Bioorg Med Chem (2013) 21, 2663-2670. PubMed Europe PubMed DOI I
Kolb,A.F., Sorrell,D., Lassnig,C., Lillico,S., Carlisle,A., Neil,C., Robinson,C., Muller,M. and Whitelaw,C.B. Mammary gland development is delayed in mice deficient for aminopeptidase N Transgenic Res (2013) 22, 425-434. PubMed Europe PubMed DOI K
Lai,A., Hosseini-Tabatabaei,A., Hartwell,R., Rahmani-Neishaboor,E., Kilani,R.T. and Ghahary,A. Topical application of aminopeptidase N-neutralizing antibody accelerates wound closure Mol Cell Biochem (2013) 372, 95-100. PubMed Europe PubMed DOI T
Logsdon,L.A. and Urbach,A.R. Sequence-specific inhibition of a nonspecific protease J Am Chem Soc (2013) 135, 11414-11416. PubMed Europe PubMed DOI I
Ma,C., Jin,K., Cao,J., Zhang,L., Li,X. and Xu,W. Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN) Bioorg Med Chem (2013) 21, 1621-1627. PubMed Europe PubMed DOI I
Ma,C., Li,X., Liang,X., Jin,K., Cao,J. and Xu,W. Novel beta-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN) Bioorg Med Chem Lett (2013) 23, 4948-4952. PubMed Europe PubMed DOI I
Su,L., Jia,Y., Wang,X., Zhang,L., Fang,H. and Xu,W. Discovery of a synthetic aminopeptidase N inhibitor LB-4b as a potential anticancer agent Bioorg Med Chem Lett (2013) 23, 2512-2517. PubMed Europe PubMed DOI I
Zhang,X., Zhang,L., Zhang,J., Feng,J., Yuan,Y., Fang,H. and Xu,W. Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors J Enzyme Inhib Med Chem (2013) 28, 545-551. PubMed Europe PubMed DOI I

2012

Albrecht,S., Salomon,E., Defoin,A. and Tarnus,C. Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors Bioorg Med Chem (2012) 20, 4942-4953. PubMed Europe PubMed DOI I
Chen,L., Lin,Y.L., Peng,G. and Li,F. Structural basis for multifunctional roles of mammalian aminopeptidase N Proc Natl Acad Sci U S A (2012) 109, 17966-17971. PubMed Europe PubMed DOI
Feng,J., Jin,K., Zhu,H., Zhang,X., Zhang,L., Liu,J. and Xu,W. A novel aminopeptidase N inhibitor developed by virtual screening approach Bioorg Med Chem Lett (2012) 22, 5863-5869. PubMed Europe PubMed DOI I
Gredicak,M., Abramic,M. and Jeric,I. Cyclic enediyne-amino acid chimeras as new aminopeptidase N inhibitors Amino Acids (2012) 43, 2087-2100. PubMed Europe PubMed DOI I
Li,Q., Fang,H., Wang,X., Hu,G., Wang,Q. and Xu,W. Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation Bioorg Med Chem Lett (2012) 22, 850-853. PubMed Europe PubMed DOI I
Roques,B.P., Fournie-Zaluski,M.C. and Wurm,M. Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain Nat Rev Drug Discov (2012) 11, 292-310. PubMed Europe PubMed DOI I
Su,L., Jia,Y., Zhang,L., Xu,Y., Fang,H. and Xu,W. Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors Bioorg Med Chem (2012) 20, 3807-3815. PubMed Europe PubMed DOI I
Turner,A.J. Aminopeptidase N [ISSN:978-0-12-407744-7] (2012) 3, 397-403. DOI
Wong,A.H., Zhou,D. and Rini,J.M. The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing J Biol Chem (2012) 287, 36804-36813. PubMed Europe PubMed DOI S I
Yang,K., Fen,J., Fang,H., Zhang,L., Gong,J. and Xu,W. Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors J Enzyme Inhib Med Chem (2012) 27, 302-310. PubMed Europe PubMed DOI I

2011

Albrecht,S., Al-Lakkis-Wehbe,M., Orsini,A., Defoin,A., Pale,P., Salomon,E., Tarnus,C. and Weibel,J.M. Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13 Bioorg Med Chem (2011) 19, 1434-1449. PubMed Europe PubMed DOI I
Chen,L.Z., Mou,J.J., Xu,Y.Y., Fang,H. and Xu,W.F. Design, synthesis and activity study of aminopeptidase N targeted 3-amino-2-hydroxy-4-phenyl-butanoic acid derivatives Drug Discov Ther (2011) 5, 61-65. PubMed Europe PubMed I
Jia,M., Yang,K., Fang,H., Xu,Y., Sun,S., Su,L. and Xu,W. Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine Bioorg Med Chem (2011) 19, 5190-5198. PubMed Europe PubMed DOI I
Li,X., Wang,J., Zhang,L. and Xu,W. Design, synthesis, and preliminary activity evaluation of novel peptidomimetics as aminopeptidase N/CD13 inhibitors Arch Pharm (Weinheim) (2011) 344, 494-504. PubMed Europe PubMed DOI I
Luan,Y., Ma,C., Sui,Z., Wang,X., Feng,J., Liu,N., Jing,F., Wang,Y., Li,M., Fang,H. and Xu,W. LYP3, a new bestatin derivative for aminopeptidase N inhibition Med Chem (2011) 7, 32-36. PubMed Europe PubMed I
Luan,Y., Wang,Q., Liu,N., Mou,J., Jiao,X., Fang,H., Li,M. and Xu,W. Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor Anticancer Drugs (2011) 22, 99-103. PubMed Europe PubMed DOI I
Piedfer,M., Dauzonne,D., Tang,R., N'guyen,J., Billard,C. and Bauvois,B. Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells FASEB J (2011) 25, 2831-2842. PubMed Europe PubMed DOI
Rao,M., Li,Q., Feng,L., Xia,X., Ruan,L., Sheng,X. and Ge,M. A new aminopeptidase inhibitor from Streptomyces strain HCCB10043 found by UPLC-MS Anal Bioanal Chem (2011) 401, 699-706. PubMed Europe PubMed DOI I
Ren,X., Liu,B., Yin,J., Zhang,H. and Li,G. Phage displayed peptides recognizing porcine aminopeptidase N inhibit transmissible gastroenteritis coronavirus infection in vitro Virology (2011) 410, 299-306. PubMed Europe PubMed DOI
Su,L., Fang,H., Yang,K., Xu,Y. and Xu,W. Design, synthesis and biological evaluation of novel l-lysine ureido derivatives as aminopeptidase N inhibitors Bioorg Med Chem (2011) 19, 900-906. PubMed Europe PubMed DOI I
Wickstrom,M., Larsson,R., Nygren,P. and Gullbo,J. Aminopeptidase N (CD13) as a target for cancer chemotherapy Cancer Sci (2011) 102, 501-508. PubMed Europe PubMed DOI V T
Zhang,X., Zhang,J., Zhang,L., Feng,J., Xu,Y., Yuan,Y., Fang,H. and Xu,W. Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors Bioorg Med Chem (2011) 19, 6015-6025. PubMed Europe PubMed DOI I

2010

Cui,S.X., Qu,X.J., Gao,Z.H., Zhang,Y.S., Zhang,X.F., Zhao,C.R., Xu,W.F., Li,Q.B. and Han,J.X. Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells Cancer Lett (2010) 292, 153-162. PubMed Europe PubMed DOI I
Drag,M., Bogyo,M., Ellman,J.A. and Salvesen,G.S. Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors J Biol Chem (2010) 285, 3310-3318. PubMed Europe PubMed DOI P
Grzywa,R., Oleksyszyn,J., Salvesen,G.S. and Drag,M. Identification of very potent inhibitor of human aminopeptidase N (CD13) Bioorg Med Chem Lett (2010) 20, 2497-2499. PubMed Europe PubMed DOI I
Grzywa,R., Sokol,A.M., Sienczyk,M., Radziszewicz,M., Kosciolek,B., Carty,M.P. and Oleksyszyn,J. New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13 Bioorg Med Chem (2010) 18, 2930-2936. PubMed Europe PubMed DOI I
Haraguchi,N., Ishii,H., Mimori,K., Tanaka,F., Ohkuma,M., Kim,H.M., Akita,H., Takiuchi,D., Hatano,H., Nagano,H., Barnard,G.F., Doki,Y. and Mori,M. CD13 is a therapeutic target in human liver cancer stem cells J Clin Invest (2010) 120, 3326-3339. PubMed Europe PubMed DOI PMC EPMC T
Inagaki,Y., Tang,W., Zhang,L., Du,G., Xu,W. and Kokudo,N. Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis Biosci Trends (2010) 4, 56-60. PubMed Europe PubMed I
Jia,M.R., Wei,T. and Xu,W.F. The analgesic activity of bestatin as a potent APN inhibitor Front Neurosci (2010) 4, 50-50. PubMed Europe PubMed DOI PMC EPMC I
Lai,A., Ghaffari,A. and Ghahary,A. Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration Mol Cell Biochem (2010) 343, 191-199. PubMed Europe PubMed DOI
Li,Q., Fang,H., Wang,X. and Xu,W. Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II Eur J Med Chem (2010) 45, 1618-1626. PubMed Europe PubMed DOI I
Padia,S.H., Howell,N.L., Kemp,B.A., Fournie-Zaluski,M.C., Roques,B.P. and Carey,R.M. Intrarenal aminopeptidase N inhibition restores defective angiotensin II type 2-mediated natriuresis in spontaneously hypertensive rats Hypertension (2010) 55, 474-480. PubMed Europe PubMed DOI I
Wang,Q., Xu,F., Mou,J., Zhang,J., Shang,L., Luan,Y., Yuan,Y., Liu,Y., Li,M., Fang,H., Wang,B. and Xu,W. Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors Protein Pept Lett (2010) 17, 847-853. PubMed Europe PubMed DOI I
Wang,X., Zhang,L., Yang,K., Zhang,C., Zhang,J., Fang,H. and Xu,W. The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor Biol Pharm Bull (2010) 33, 1658-1665. PubMed Europe PubMed I
Zhang,X., Fang,H., Zhu,H., Wang,X., Zhang,L., Li,M., Li,Q., Yuan,Y. and Xu,W. Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione Bioorg Med Chem (2010) 18, 5981-5987. PubMed Europe PubMed DOI I

2009

Ansorge,S., Bank,U., Heimburg,A., Helmuth,M., Koch,G., Tadje,J., Lendeckel,U., Wolke,C., Neubert,K., Faust,J., Fuchs,P., Reinhold,D., Thielitz,A. and Tager,M. Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions Clin Chem Lab Med (2009) 47, 253-261. PubMed Europe PubMed DOI
Li,Q., Fang,H., Wang,X., Hu,L. and Xu,W. Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I Eur J Med Chem (2009) 44, 4819-4825. PubMed Europe PubMed DOI I
Li,S.H., Li,G., Huang,H.M., Xiong,F., Mai,X., Kuang,B.H., Liu,C.M. and Tu,G.G. Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors Pharmazie (2009) 64, 67-70. PubMed Europe PubMed DOI I
Li,X., Wang,Y., Wu,J., Li,Y., Wang,Q. and Xu,W. Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II) Bioorg Med Chem (2009) 17, 3061-3071. PubMed Europe PubMed DOI I
Li,X., Wang,J., Li,J., Wu,J., Li,Y., Zhu,H., Fan,R. and Xu,W. Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I) Bioorg Med Chem (2009) 17, 3053-3060. PubMed Europe PubMed DOI I
Liu,B., Li,G., Sui,X., Yin,J., Wang,H. and Ren,X. Expression and functional analysis of porcine aminopeptidase N produced in prokaryotic expression system J Biotechnol (2009) 141, 91-96. PubMed Europe PubMed DOI E
Liu,Y., Shang,L., Fang,H., Zhu,H., Mu,J., Wang,Q., Wang,X., Yuan,Y. and Xu,W. Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13 Bioorg Med Chem (2009) 17, 7398-7404. PubMed Europe PubMed DOI I
Luan,Y., Wang,X., Zhu,H., Qu,X., Fang,H. and Xu,W. The synthesis and activity evaluation of a bestatin derivative (LYP) as an aminopeptidase N inhibitor Lett Drug Des Discov (2009) 6, 420-423. DOI I
Morikawa,T., Xie,H., Wang,T., Matsuda,H. and Yoshikawa,M. Acylated flavonol bisdesmosides, sinocrassosides A3-A7 and B3, with aminopeptidase N inhibitory activity from Sinocrassula indica Chem Biodivers (2009) 6, 411-420. PubMed Europe PubMed DOI I
Mou,J., Fang,H., Jing,F., Wang,Q., Liu,Y., Zhu,H., Shang,L., Wang,X. and Xu,W. Design, synthesis and primary activity evaluation of l-arginine derivatives as amino-peptidase N/CD13 inhibitors Bioorg Med Chem (2009) 17, 4666-4673. PubMed Europe PubMed DOI I
Shang,L., Fang,H., Zhu,H., Wang,X., Wang,Q., Mu,J., Wang,B., Kishioka,S. and Xu,W. Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors Bioorg Med Chem (2009) 17, 2775-2784. PubMed Europe PubMed DOI I
Yang,K., Wang,Q., Su,L., Fang,H., Wang,X., Gong,J., Wang,B. and Xu,W. Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors Bioorg Med Chem (2009) 17, 3810-3817. PubMed Europe PubMed DOI I

2008

Danziger,R.S. Aminopeptidase N in arterial hypertension Heart Fail Rev (2008) 13, 293-298. PubMed Europe PubMed DOI V
Grzywa,R. and Oleksyszyn,J. First synthesis of alpha-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group Bioorg Med Chem Lett (2008) 18, 3734-3736. PubMed Europe PubMed DOI I
John,H., John,S. and Forssmann,W.G. Kinetic studies on aminopeptidase M-mediated degradation of human hemorphin LVV-H7 and its N-terminally truncated products J Pept Sci (2008) 14, 797-803. PubMed Europe PubMed DOI
Mina-Osorio,P. The moonlighting enzyme CD13: old and new functions to target Trends Mol Med (2008) 14, 361-371. PubMed Europe PubMed DOI
Shang,L., Maeda,T., Xu,W. and Kishioka,S. Evaluation of a novel aminopeptidase N inhibitor, in vitro, using two assay systems J Enzyme Inhib Med Chem (2008) 23, 198-205. PubMed Europe PubMed DOI A I
Shang,L., Wang,Q., Fang,H., Mu,J., Wang,X., Yuan,Y., Wang,B. and Xu,W. Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN) Bioorg Med Chem (2008) 16, 9984-9990. PubMed Europe PubMed DOI I
Shim,J.S., Park,H.M., Lee,J. and Kwon,H.J. Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition Biochem Biophys Res Commun (2008) 371, 99-103. PubMed Europe PubMed DOI I
Tu,G., Li,S., Huang,H., Li,G., Xiong,F., Mai,X., Zhu,H., Kuang,B. and Xu,W.F. Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold Bioorg Med Chem (2008) 16, 6663-6668. PubMed Europe PubMed DOI I
Willemse,J.L., Chen,D. and Hendriks,D.F. Major carboxypeptidase N deficiency Clin Chim Acta (2008) 389, 181-182. PubMed Europe PubMed DOI M
Wulfaenger,J., Niedling,S., Riemann,D. and Seliger,B. Aminopeptidase N (APN)/CD13-dependent CXCR4 downregulation is associated with diminished cell migration, proliferation and invasion Mol Membr Biol (2008) 25, 72-82. PubMed Europe PubMed DOI
Zhang,X. and Xu,W. Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design Curr Med Chem (2008) 15, 2850-2865. PubMed Europe PubMed DOI V I

2007

Kotlo,K., Shukla,S., Tawar,U., Skidgel,R.A. and Danziger,R.S. Aminopeptidase N reduces basolateral Na+-K+-ATPase in proximal tubule cells Am J Physiol Renal Physiol (2007) 293, F1047-F1053. PubMed Europe PubMed DOI
Li,B.X., Ge,J.W. and Li,Y.J. Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus Virology (2007) 365, 166-172. PubMed Europe PubMed DOI
Luan,Y. and Xu,W. The structure and main functions of aminopeptidase N Curr Med Chem (2007) 14, 639-647. PubMed Europe PubMed DOI V
Petrovic,N., Schacke,W., Gahagan,J.R., O'Conor,C.A., Winnicka,B., Conway,R.E., Mina-Osorio,P. and Shapiro,L.H. CD13/APN regulates endothelial invasion and filopodia formation Blood (2007) 110, 142-150. PubMed Europe PubMed DOI PMC EPMC
Proost,P., Mortier,A., Loos,T., Vandercappellen,J., Gouwy,M., Ronsse,I., Schutyser,E., Put,W., Parmentier,M., Struyf,S. and Van Damme,J. Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration Blood (2007) 110, 37-44. PubMed Europe PubMed DOI
Rangel,R., Sun,Y., Guzman-Rojas,L., Ozawa,M.G., Sun,J., Giordano,R.J., Van Pelt,C.S., Tinkey,P.T., Behringer,R.R., Sidman,R.L., Arap,W. and Pasqualini,R. Impaired angiogenesis in aminopeptidase N-null mice Proc Natl Acad Sci U S A (2007) 104, 4588-4593. PubMed Europe PubMed DOI PMC EPMC K
Reinhold,D., Biton,A., Goihl,A., Pieper,S., Lendeckel,U., Faust,J., Neubert,K., Bank,U., Tager,M., Ansorge,S. and Brocke,S. Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses Ann N Y Acad Sci (2007) 1110, 402-409. PubMed Europe PubMed DOI
Stragier,B., Demaegdt,H., De Bundel,D., Smolders,I., Sarre,S., Vauquelin,G., Ebinger,G., Michotte,Y. and Vanderheyden,P. Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat Brain Res (2007) 1131, 97-105. PubMed Europe PubMed DOI I
Thielitz,A., Reinhold,D., Vetter,R., Bank,U., Helmuth,M., Hartig,R., Wrenger,S., Wiswedel,I., Lendeckel,U., Kahne,T., Neubert,K., Faust,J., Zouboulis,C.C., Ansorge,S. and Gollnick,H. Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation J Invest Dermatol (2007) 127, 1042-1051. PubMed Europe PubMed DOI T I

2006

Alfalah,M., Krahn,M.P., Wetzel,G., von Horsten,S., Wolke,C., Hooper,N., Kalinski,T., Krueger,S., Naim,H.Y. and Lendeckel,U. A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum J Biol Chem (2006) 281, 11894-11900. PubMed Europe PubMed DOI M
[YEAR:20-12-2006]Bank,U., Heimburg,A., Helmuth,M., Stefin,S., Lendeckel,U., Reinhold,D., Faust,J., Fuchs,P., Sens,B., Neubert,K., Tager,M. and Ansorge,S. Triggering endogenous immunosuppressive mechanisms by combined targeting of dipeptidyl peptidase IV (DPIV/CD26) and aminopeptidase N (APN/ CD13) - a novel approach for the treatment of inflammatory bowel disease Int Immunopharmacol (20-12-2006) 6, 1925-1934. PubMed Europe PubMed DOI I
[YEAR:7-10-2006]Bauvois,B. and Dauzonne,D. Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects Med Res Rev (7-10-2006) 26, 88-130. PubMed Europe PubMed DOI T I
[YEAR:8-8-2006]Kitabgi,P. Inactivation of neurotensin and neuromedin N by Zn metallopeptidases Peptides (8-8-2006) 27, 2515-2522. PubMed Europe PubMed DOI V
Wisner,A., Dufour,E., Messaoudi,M., Nejdi,A., Marcel,A., Ungeheuer,M.N. and Rougeot,C. Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways Proc Natl Acad Sci U S A (2006) 103, 17979-17984. PubMed Europe PubMed DOI PMC EPMC I

2005

Kato,M., Azuma,H., Akaike,M., Iuchi,T., Aihara,K., Ikeda,Y., Fujimura,M., Yoshida,T., Yamaguchi,H., Hashizume,S. and Matsumoto,T. Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression Atherosclerosis (2005) 183, 49-55. PubMed Europe PubMed DOI
[YEAR:3-1-2005]Lee,J., Shim,J.S., Jung,S.A., Lee,S.T. and Kwon,H.J. N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity Bioorg Med Chem Lett (3-1-2005) 15, 181-183. PubMed Europe PubMed DOI I

2004

[YEAR:15-10-2004]Gredmark,S., Britt,W.B., Xie,X., Lindbom,L. and Soderberg-Naucler,C. Human cytomegalovirus induces inhibition of macrophage differentiation by binding to human aminopeptidase N/CD13 J Immunol (15-10-2004) 173, 4897-4907. PubMed Europe PubMed
Sakane,N., Asano,Y., Kawamura,T., Takatani,T., Kohama,Y., Tsujikawa,K. and Yamamoto,H. Aminopeptidase N/CD13 regulates the fetal liver microenvironment of hematopoiesis Biol Pharm Bull (2004) 27, 2014-2020. PubMed Europe PubMed DOI
Turner,A.J. Membrane alanyl aminopeptidase [ISSN:0-12-079610-4] (2004) 2, 289-294. V

2003

Bukowska,A., Tadje,J., Arndt,M., Wolke,C., Kahne,T., Bartsch,J., Faust,J., Neubert,K., Hashimoto,Y. and Lendeckel,U. Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets Biol Chem (2003) 384, 657-665. PubMed Europe PubMed DOI I
Kawai,M., Otake,Y. and Hara,Y. High-molecular-mass isoform of aminopeptidase N/CD13 in serum from cholestatic patients Clin Chim Acta (2003) 330, 141-149. PubMed Europe PubMed DOI
Kido,A., Krueger,S., Haeckel,C. and Roessner,A. Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells Clin Exp Metastasis (2003) 20, 585-592. PubMed Europe PubMed DOI
Le Guen,S., Mas Nieto,M., Canestrelli,C., Chen,H., Fournie-Zaluski,M.C., Cupo,A., Maldonado,R., Roques,B.P. and Noble,F. Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone Pain (2003) 104, 139-148. PubMed Europe PubMed DOI I

2002

[YEAR:1-4-2002]Firla,B., Arndt,M., Frank,K., Thiel,U., Ansorge,S., Tager,M. and Lendeckel,U. Extracellular cysteines define ectopeptidase (APN, CD13) expression and function Free Radic Biol Med (1-4-2002) 32, 584-595. PubMed Europe PubMed DOI
Janas,R.M., Socha,J., Janas,J. and Warnawin,K. Neutral endopeptidase activity is not elevated in serum in children with cholestatic liver disease: a unique role of aminopeptidase-M in sequential hydrolysis of peptides Dig Dis Sci (2002) 47, 1766-1774. PubMed Europe PubMed DOI
Lohn,M., Mueller,C. and Langner,J. Cell cycle retardation in monocytoid cells induced by aminopeptidase N (CD13) Leuk Lymphoma (2002) 43, 407-413. PubMed Europe PubMed DOI
Shimizu,T., Tani,K., Hase,K., Ogawa,H., Huang,L., Shinomiya,F. and Sone,S. CD13/aminopeptidase N-induced lymphocyte involvement in inflamed joints of patients with rheumatoid arthritis Arthritis Rheum (2002) 46, 2330-2338. PubMed Europe PubMed DOI

2001

[YEAR:1-2-2001]Bhagwat,S.V., Lahdenranta,J., Giordano,R., Arap,W., Pasqualini,R. and Shapiro,L.H. CD13/APN is activated by angiogenic signals and is essential for capillary tube formation Blood (1-2-2001) 97, 652-659. PubMed Europe PubMed DOI
Dybkaer,K., Kristensen,J.S. and Pedersen,F.S. Single site polymorphisms and alternative splicing of the human CD13 gene - different splicing frequencies among patients with acute myeloid leukaemia and healthy individuals Br J Haematol (2001) 112, 691-696. PubMed Europe PubMed DOI M
Kawai,M., Hara,Y., Miyazato,I. and Hosaki,S. Novel, aberrantly truncated isoform of serum CD13 in a family with high serum aminopeptidase N (CD13) activity Clin Chem (2001) 47, 223-230. PubMed Europe PubMed
Kehlen,A., Egbert,I., Thiele,K., Fischer,K., Riemann,D. and Langner,J. Increased expression of interleukin-8 and aminopeptidase N by cell-cell contact: interleukin-8 is resistant to degradation by aminopeptidase N/CD13 Eur Cytokine Netw (2001) 12, 316-324. PubMed Europe PubMed
[YEAR:15-5-2001]Matthews,K.W. and Wetsel,R.A. Characterization of mouse carboxypeptidase N small active subunit gene structure J Immunol (15-5-2001) 166, 6196-6202. PubMed Europe PubMed
Najjar,S.M., Broyart,J.P., Hampp,L.T. and Gray,G.M. Intestinal aminooligopeptidase in diabetic BioBreed rat: altered posttranslational processing and trafficking Am J Physiol Gastrointest Liver Physiol (2001) 280, G104-G112. PubMed Europe PubMed
van der Velden,V.H., Leenen,P.J. and Drexhage,H.A. CD13/aminopeptidase N involvement in dendritic cell maturation Leukemia (2001) 15, 190-191. PubMed Europe PubMed DOI
Wentworth,D.E. and Holmes,K.V. Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation J Virol (2001) 75, 9741-9752. PubMed Europe PubMed DOI PMC EPMC

2000

[YEAR:6-4-2000]Chen,H., Noble,F., Mothe,A., Meudal,H., Coric,P., Danascimento,S., Roques,B.P., George,P. and Fournie-Zaluski,M.C. Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities J Med Chem (6-4-2000) 43, 1398-1408. PubMed Europe PubMed DOI I
[YEAR:24-6-2000]Lendeckel,U., Scholz,B., Arndt,M., Frank,K., Spiess,A., Chen,H., Roques,B.P. and Ansorge,S. Inhibition of alanyl-aminopeptidase suppresses the activation-dependent induction of glycogen synthase kinase-3beta (GSK-3beta) in human T cells Biochem Biophys Res Commun (24-6-2000) 273, 62-65. PubMed Europe PubMed DOI I
[YEAR:10-4-2000]Santos,A.N., Langner,J., Herrmann,M. and Riemann,D. Aminopeptidase N/CD13 is directly linked to signal transduction pathways in monocytes Cell Immunol (10-4-2000) 201, 22-32. PubMed Europe PubMed DOI

1999

[YEAR:7-6-1999]Chen,H., Roques,B.P. and Fournie-Zaluski,M.C. Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor Bioorg Med Chem Lett (7-6-1999) 9, 1511-1516. PubMed Europe PubMed DOI I
[YEAR:1-11-1999]de Gandarias,J.M., Irazusta,J., Gil,J., Fernandez,D., Varona,A. and Casis,L. Ontogeny of puromycin-sensitive and insensitive aminopeptidase activities in several subcellular fractions of the rat brain Brain Res Bull (1-11-1999) 50, 283-290. PubMed Europe PubMed DOI
Douglas,S.E., Gallant,J.W. and Bullerwell,C.E. Molecular investigation of aminopeptidase N expression in the winter flounder, Pleuronectes americanus J Appl Ichthyol (1999) 15, 80-86.
Reaux,A., de Mota,N., Zini,S., Cadel,S., Fournie-Zaluski,M.C., Roques,B.P., Corvol,P. and Llorens-Cortes,C. PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III Neuroendocrinology (1999) 69, 370-376. PubMed Europe PubMed DOI I
Shimazawa,R., Takayama,H., Fujimoto,Y., Komoda,M., Dodo,K., Yamasaki,R., Shirai,R., Koiso,Y., Miyata,K., Kato,F., Kato,M., Miyachi,H. and Hashimoto,Y. Novel small molecule nonpeptide aminopeptidase N inhibitors with a cyclic imide skeleton J Enzyme Inhib (1999) 14, 259-275. PubMed Europe PubMed I

1998

[YEAR:20-8-1998]Gillis,L.D., Pendley,D.S. and Funkhouser,J.D. The major APN transcript of the alveolar type II epithelial cell originates from a unique upstream promoter region Biochim Biophys Acta (20-8-1998) 1399, 126-140. PubMed Europe PubMed DOI
[YEAR:13-1-1998]Luciani,N., Marie-Claire,C., Ruffet,E., Beaumont,A., Roques,B.P. and Fournie-Zaluski,M.C. Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): Insights into its mechanism of action Biochemistry (13-1-1998) 37, 686-692. PubMed Europe PubMed DOI

1997

Benbacer,L., Kut,E., Besnardeau,L., Laude,H. and Delmas,B. Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus J Virol (1997) 71, 734-737. PubMed Europe PubMed PMC EPMC
Bernkop-Schnurch,A. and Marschutz,M.K. Development and in vitro evaluation of systems to protect peptide drugs from aminopeptidase N Pharm Res (1997) 14, 181-185. PubMed Europe PubMed DOI
Dimitrova,M., Dikov,A. and Salzer,M. Fluorescent demonstration of alanine aminopeptidase using a new substrate, based on a thioxanthene derivative C R Acad Bulg Sci (1997) 50, 97-100. L
Nagai,M., Kojima,F., Naganawa,H., Hamada,M., Aoyagi,T. and Takeuchi,T. Phebestin, a new inhibitor of aminopeptidase N, produced by Streptomyces sp. MJ716-m3 J Antibiot (Tokyo) (1997) 50, 82-84. PubMed Europe PubMed I
Noble,F. and Roques,B.P. Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice FEBS Lett (1997) 401, 227-229. PubMed Europe PubMed DOI
Parenti,P., Morandi,P., McGivan,J.D., Consonnic,P., Leonardi,G. and Giordana,B. Properties of the aminopeptidase N from the silkworm midgut (Bombyx mori) Insect Biochem Mol Biol (1997) 27, 397-403. I
Pemberton,P.W., Lobley,R.W., Sorensen,S.H. and Batt,R.M. An aminopeptidase N deficiency in dog small intestine Res Vet Sci (1997) 63, 133-138. PubMed Europe PubMed K

1996

Dikov,A. and Dimitrova,M. New fluorogenic substrates in histochemistry of peptidases: I. Histochemical determination of alanine aminopeptidase C R Acad Bulg Sci (1996) 49, 89-92. L
Fujii,H., Nakajima,M., Aoyagi,T. and Tsuruo,T. Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors Biol Pharm Bull (1996) 19, 6-10. PubMed Europe PubMed T I
Lendeckel,U., Wex,T., Reinhold,D., Kahne,T., Frank,K., Faust,J., Neubert,K. and Ansorge,S. Induction of the membrane alanyl aminopeptidase gene and surface expression in human T-cells by mitogenic activation Biochem J (1996) 319, 817-821. PubMed Europe PubMed PMC EPMC I
Lerche,C., Vogel,L.K., Shapiro,L.H., Noren,O. and Sjostrom,H. Human aminopeptidase N is encoded by 20 exons Mamm Genome (1996) 7, 712-713. PubMed Europe PubMed

1995

Piela-Smith,T.H. and Korn,J.H. Aminopeptidase N: A constitutive cell-surface protein on human dermal fibroblasts Cell Immunol (1995) 162, 42-48. PubMed Europe PubMed DOI
Safavi,A. and Hersh,L.B. Degradation of dynorphin-related peptides by the puromycin-sensitive aminopeptidase and aminopeptidase M J Neurochem (1995) 65, 389-395. PubMed Europe PubMed
Watanabe,Y., Iwaki-Egawa,S., Mizukoshi,H. and Fujimoto,Y. Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N Biol Chem Hoppe Seyler (1995) 376, 397-400. PubMed Europe PubMed

1994

Chauvel,E.N., Llorens-Cortes,C., Coric,P., Wilk,S., Roques,B.P. and Fournie-Zaluski,M.C. Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols J Med Chem (1994) 37, 2950-2957. PubMed Europe PubMed I
[YEAR:15-3-1994]Hooper,N.M., Hesp,R.J. and Tieku,S. Metabolism of aspartame by human and pig intestinal microvillar peptidases Biochem J (15-3-1994) 298, 635-639. PubMed Europe PubMed PMC EPMC
[YEAR:1-3-1994]Murray,H., Turner,A.J. and Kenny,A.J. The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13) Biochem J (1-3-1994) 298, 353-360. PubMed Europe PubMed PMC EPMC I
O'Callaghan,B., Synguelakis,M., Le Gal la Salle,G. and Morel,N. Characterization of aminopeptidase N from Torpedo marmorata kidney Biol Cell (1994) 81, 121-130. PubMed Europe PubMed DOI
Schalk,C., D'Orchymont,H., Jauch,M.F. and Tarnus,C. 3-Amino-2-tetralone derivatives: novel potent and selective inhibitors of aminopeptidase-M (EC 3.4.11.2) Arch Biochem Biophys (1994) 311, 42-46. PubMed Europe PubMed DOI I

1993

Favaloro,E.J., Browning,T. and Facey,D. CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated Exp Hematol (1993) 21, 1695-1701. PubMed Europe PubMed

1992

[YEAR:4-6-1992]Delmas,B., Gelfi,J., L'Haridon,R., Vogel,L.K., Sjostrom,H., Noren,O. and Laude,H. Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV Nature (4-6-1992) 357, 417-420. PubMed Europe PubMed DOI
Gillespie,T.J., Konings,P.N., Merrill,B.J. and Davis,T.P. A specific enzyme assay for aminopeptidase M in rat brain Life Sci (1992) 51, 2097-2106. PubMed Europe PubMed DOI I
Ocain,T.D. and Rich,D.H. alpha-Keto amide inhibitors of aminopeptidases J Med Chem (1992) 35, 451-456. PubMed Europe PubMed I
[YEAR:10-8-1992]Vogel,L.K., Noren,O. and Sjostrom,H. The apical sorting signal on human aminopeptidase N is not located in the stalk but in the catalytic head group FEBS Lett (10-8-1992) 308, 14-17. PubMed Europe PubMed DOI
[YEAR:4-6-1992]Yeager,C.L., Ashmun,R.A., Williams,R.K., Cardellichio,C.B., Shapiro,L.H., Look,A.T. and Holmes,K.V. Human aminopeptidase N is a receptor for human coronavirus 229E Nature (4-6-1992) 357, 420-422. PubMed Europe PubMed DOI

1991

Funkhouser,J.D., Tangada,S.D., Jones,M., O,S.J. and Peterson,R.D. p146 type II alveolar epithelial cell antigen is identical to aminopeptidase N Am J Physiol (1991) 260, L274-L279. PubMed Europe PubMed

1990

Lenney,J.F. Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase) Biol Chem Hoppe Seyler (1990) 371, 433-440. PubMed Europe PubMed
Ward,P.E., Benter,I.F., Dick,L. and Wilk,S. Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M Biochem Pharmacol (1990) 40, 1725-1732. PubMed Europe PubMed DOI P
Watt,V.M. and Willard,H.F. The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis Hum Genet (1990) 85, 651-654. PubMed Europe PubMed M

1989

[YEAR:18-4-1989]Lejczak,B., Kafarski,P. and Zygmunt,J. Inhibition of aminopeptidases by aminophosphonates Biochemistry (18-4-1989) 28, 3549-3555. PubMed Europe PubMed
Look,A.T., Ashmun,R.A., Shapiro,L.H. and Peiper,S.C. Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N J Clin Invest (1989) 83, 1299-1307. PubMed Europe PubMed DOI PMC EPMC
Malfroy,B., Kado-Fong,H., Gros,C., Giros,B., Schwartz,J.C. and Hellmiss,R. Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases Biochem Biophys Res Commun (1989) 161, 236-241. PubMed Europe PubMed

1988

[YEAR:7-11-1988]Kruse,T.A., Bolund,L., Grzeschik,K.H., Ropers,H.H., Olsen,J., Sjostrom,H. and Noren,O. Assignment of the human aminopeptidase N (peptidase E) gene to chromosome 15q13-qter FEBS Lett (7-11-1988) 239, 305-308. PubMed Europe PubMed
Ocain,T.D. and Rich,D.H. Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues J Med Chem (1988) 31, 2193-2199. PubMed Europe PubMed I
Olsen,J., Cowell,G.M., Koenigshoefer,E., Danielsen,E.M., Moeller,J., Laustsen,L., Hansen,O.C., Welinder,K.G., Engberg,J., Hunziker,W., Spiess,M., Sjoestroem,H. and Noren,O. Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA FEBS Lett (1988) 238, 307-314. PubMed Europe PubMed

1986

McDonald,J.K. and Barrett,A.J. Mammalian Proteases: a Glossary and Bibliography. Volume 2: Exopeptidases [ISSN:ISBN 0-12-079502-7] (1986)

1985

[YEAR:25-10-1985]Wilkes,S.H. and Prescott,J.M. The slow, tight binding of bestatin and amastatin to aminopeptidases J Biol Chem (25-10-1985) 260, 13154-13162. PubMed Europe PubMed I

1984

[YEAR:11-6-1984]Antonov,V.K., Vorotyntseva,T.I., Bessmertnaya,L.Y., Mikhailova,A.G. and Zilberman,M.I. Role of intestinal brush border membrane aminopeptidase N in dipeptide transport FEBS Lett (11-6-1984) 171, 227-232. PubMed Europe PubMed DOI
Jung,K., Pergande,M. and Wischke,U.W. Characterization of particulate and soluble variants of the brush-border enzymes alanine aminopeptidase, alkaline phosphatase and gamma-glutamyltransferase in human urine Biomed Biochim Acta (1984) 43, 1357-1364. PubMed Europe PubMed
Rich,D.H., Moon,B.J. and Harbeson,S. Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes J Med Chem (1984) 27, 417-422. PubMed Europe PubMed I

1983

[YEAR:15-3-1983]Leyhausen,G., Schuster,D.K., Vaith,P., Zahn,R.K., Umezawa,H., Falke,D. and Muller,W.E. Identification and properties of the cell membrane bound leucine aminopeptidase interacting with the potential immunostimulant and chemotherapeutic agent bestatin Biochem Pharmacol (15-3-1983) 32, 1051-1057. PubMed Europe PubMed DOI I
[YEAR:22-11-1983]Miura,S., Song,I.S., Morita,A., Erickson,R.H. and Kim,Y.S. Distribution and biosynthesis of aminopeptidase N and dipeptidyl aminopeptidase IV in rat small intestine Biochim Biophys Acta (22-11-1983) 761, 66-75. PubMed Europe PubMed DOI
[YEAR:25-11-1983]Wilkes,S.H. and Prescott,J.M. Stereospecificity of amino acid hydroxamate inhibition of aminopeptidases J Biol Chem (25-11-1983) 258, 13517-13521. PubMed Europe PubMed I

1982

[YEAR:26-7-1982]Gratecos,D., Varesi,L., Knibiehler,M. and Semeriva,M. Photoaffinity labeling of membrane-bound porcine aminopeptidase N Biochim Biophys Acta (26-7-1982) 705, 218-227. PubMed Europe PubMed
[YEAR:10-6-1982]Kozak,E.M. and Tate,S.S. Glutathione-degrading enzymes of microvillus membranes J Biol Chem (10-6-1982) 257, 6322-6327. PubMed Europe PubMed

1981

[YEAR:1-9-1981]Benajiba,A. and Maroux,S. Subunit structured of pig small-intestinal brush-border aminopeptidase N Biochem J (1-9-1981) 197, 573-580. PubMed Europe PubMed PMC EPMC
[YEAR:13-3-1981]Feracci,H., Benajiba,A., Gorvel,J.P., Doumeng,C. and Maroux,S. Enzymatic and immunological properties of the protease form of aminopeptidase N and A from pig and rabbit intestinal brush border Biochim Biophys Acta (13-3-1981) 658, 148-157. PubMed Europe PubMed
[YEAR:12-10-1981]Gaertner,H., Puigserver,A. and Maroux,S. Hydrolysis of the isopeptide bond of epsilon-N-L-methionyl-L-lysine by intestinal aminopeptidase N FEBS Lett (12-10-1981) 133, 135-138. PubMed Europe PubMed

1980

Feracci,H. and Maroux,S. Rabbit intestinal aminopeptidase N. Purification and molecular properties Biochim Biophys Acta (1980) 599, 448-463. PubMed Europe PubMed
[YEAR:27-5-1980]Maze,M. and Gray,G.M. Intestinal brush border aminooligopeptidases: cytosol precursors of the membrane enzyme Biochemistry (27-5-1980) 19, 2351-2358. PubMed Europe PubMed
[YEAR:1-11-1980]Plummer,T.H., Jr. and Kimmel,M.T. An improved spectrophotometric assay for human plasma carboxypeptidase N Anal Biochem (1-11-1980) 108, 348-353. PubMed Europe PubMed DOI A

1979

[YEAR:1-3-1979]Miller,R. and Lacefield,W. Specific inhibitors of aminopeptidase M. Relationship to anti-inflammatory activity Biochem Pharmacol (1-3-1979) 28, 673-675. PubMed Europe PubMed DOI I

1977

[YEAR:1-11-1977]Hiwada,K. and Kokubu,T. Comparison of soluble and membrane-bound neutral arylamidases from renal cell carcinoma Clin Chim Acta (1-11-1977) 80, 395-401. PubMed Europe PubMed
[YEAR:25-7-1977]Kania,R.K., Santiago,N.A. and Gray,G.M. Intestinal surface amino-oligopeptidases. II. Substrate kinetics and topography of the active site J Biol Chem (25-7-1977) 252, 4929-4934. PubMed Europe PubMed P

1976

[YEAR:11-11-1976]Vannier,C., Louvard,D., Maroux,S. and Desnuelle,P. Structural and topological homology between porcine intestinal and renal brush border aminopeptidase Biochim Biophys Acta (11-11-1976) 455, 185-199. PubMed Europe PubMed
[YEAR:8-4-1976]Wacker,H., Lehky,P., Vanderhaeghe,F. and Stein,E.A. On the subunit structure of particulate aminopeptidase from pig kidney Biochim Biophys Acta (8-4-1976) 429, 546-554. PubMed Europe PubMed

1975

[YEAR:1-1-1975]Takesue,Y. Purification and properties of leucine beta-naphthylamidase from rabbit small-intestinal mucosal cells J Biochem (1-1-1975) 77, 103-115. PubMed Europe PubMed

1974

Femfert,U. and Cichocki,P. Hydrophobic areas at the active site of aminopeptidase M Hoppe Seylers Z Physiol Chem (1974) 355, 1332-1334. PubMed Europe PubMed
Starnes,W.L. and Behal,F.J. A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein Biochemistry (1974) 13, 3221-3227. PubMed Europe PubMed

1973

[YEAR:15-9-1973]Lehky,P., Lisowski,J., Wolf,D.P., Wacker,H. and Stein,E.A. Pig kidney particulate aminopeptidase. A zinc metalloenzyme Biochim Biophys Acta (15-9-1973) 321, 274-281. PubMed Europe PubMed

1972

[YEAR:1-10-1972]Femfert,U., Cichocki,P. and Pfleiderer,G. On the mechanism of amide bond cleavage catalyzed by aminopeptidase M. Enzymatic properties of nitroaminopeptidase M FEBS Lett (1-10-1972) 26, 39-42. PubMed Europe PubMed

1971

Femfert,U. On the mechanism of amide bond cleavage catalyzed by aminopeptidase M. Kinetic studies in deuteriumoxide FEBS Lett (1971) 14, 92-94. PubMed Europe PubMed
Femfert,U. and Pfleiderer,G. The effect of cations and complexing agents on the hydrolysis of L-alanine-4-nitroanilide by aminopeptidase M FEBS Lett (1971) 14, 89-91. PubMed Europe PubMed
Wacker,H., Lehky,P., Fischer,E.H. and Stein,E.A. Physical and chemical characterization of pig kidney particulate aminopeptidase Helv Chim Acta (1971) 54, 473-485. PubMed Europe PubMed DOI

1970

[YEAR:11-5-1970]Femfert,U. and Pfleiderer,G. On the mechanism of amide-bond-cleavage catalyzed by aminopeptidase M. kinetic studies FEBS Lett (11-5-1970) 8, 65-67. PubMed Europe PubMed

1969

Femfert,U. and Pfleiderer,G. The tyrosyl residues at the active site of aminopeptidase M modifications by tetranitromethane FEBS Lett (1969) 4, 262-264. PubMed Europe PubMed
Pfleiderer,G. and Femfert,U. Histidine residues at the active site of aminopeptidase M modifications by diazonium-1-h-tetrazole (dht) FEBS Lett (1969) 4, 265-268. PubMed Europe PubMed I

1967

Hanson,H., Glasser,D., Ludewig,M., Mannsfeldt,H.G. and John,M. [Structural and activity identity of leucine aminopeptidase from pig kidney and bovine lens, and comparison with particulate aminopeptidase from pig kidney] Hoppe Seylers Z Physiol Chem (1967) 348, 689-704. PubMed Europe PubMed
Hanson,H., Hutter,H.J., Mannsfeldt,H.G., Kretschmer,K. and Sohr,C. [On the demonstration and substrate specificity of a kidney particle aminopeptidase distinguishable from leucine aminopeptidase] Hoppe Seylers Z Physiol Chem (1967) 348, 680-688. PubMed Europe PubMed
[YEAR:27-1-1967]Wachsmuth,E.D. [Studies on the structure of aminopeptidase from particles of pig kidneys] Biochem Z (27-1-1967) 346, 467-473. PubMed Europe PubMed

1966

Felgenhauer,K. and Glenner,G.G. The enzymatic hydrolysis of amino acid beta-naphthylamides. II. Partial purification and properties of a particle-bound cobalt-activated rat kidney aminopeptidase J Histochem Cytochem (1966) 14, 401-413. PubMed Europe PubMed
Wachsmuth,E.D., Fritze,I. and Pfleiderer,G. An aminopeptidase occurring in pig kidney. I. An improved method of preparation. Physical and enzymic properties Biochemistry (1966) 5, 169-174. PubMed Europe PubMed
[YEAR:7-6-1966]Wachsmuth,E.D. [Comparative studies on the action mechanism of aminopeptidases] Biochem Z (7-6-1966) 344, 361-374. PubMed Europe PubMed

1964

[YEAR:23-12-1964]Loughlin,R.E. and Trikojus,V.M. A metal-dependent peptidase from thyroid glands Biochim Biophys Acta (23-12-1964) 92, 529-542. PubMed Europe PubMed
[YEAR:6-11-1964]Pfleiderer,G., Celliers,P.G., Stanulovic,M., Wachsmuth,E.D., Determann,H. and Braunitzer,G. [Properties and analytical uses of aminopeptidase from kidney particles] Biochem Z (6-11-1964) 340, 552-564. PubMed Europe PubMed

1963

Patterson,E.K., Hsiao,S.H. and Keppel,A. Studies on dipeptidases and aminopeptidases. I. Distinction between leucine aminopeptidase and enzymes that hydrolyze l-leucyl-beta-naphthylamide J Biol Chem (1963) 238, 3611-3620. PubMed Europe PubMed
[YEAR:3-12-1963]Pfleiderer,G. and Celliers,P.G. [Isolation of an aminopeptidase from kidney particles] Biochem Z (3-12-1963) 339, 186-189. PubMed Europe PubMed

1957

Binkley,F., Alexander,V., Bell,F.E. and Lea,C. Peptidases and alkaline phosphatases of swine kidney J Biol Chem (1957) 228, 559-567. PubMed Europe PubMed
Semenza,G. Chromatographic purification of cysteinyl-glycinase Biochim Biophys Acta (1957) 24, 401-413. PubMed Europe PubMed

1955

Smith,E.L. [9] Aminopeptidases Methods Enzymol (1955) 2, 83-93. DOI

1951

[YEAR:2-6-1951]Binkley,F. Metabolism of glutathione Nature (2-6-1951) 167, 888-889. PubMed Europe PubMed DOI

1948

Binkley,F. and Nakamura,K. Metabolism of glutathione. I. Hydrolysis by tissues of the rat J Biol Chem (1948) 173, 411-421. PubMed Europe PubMed