$VAR1 = undef;

Summary for peptidase C37.001: calicivirin

Names
MEROPS Name	calicivirin
Other names	Camberwell virus processing peptidase, Chiba virus processing peptidase, norovirus 3C-like peptidase, norovirus NS6 endopeptidase, norovirus virus processing peptidase, Norwalk virus processing peptidase, Southampton virus processing peptidase

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C37 >> Subfamily (none) >> C37.001
Holotype	calicivirin (Southampton virus), Uniprot accession Q04544 (peptidase unit: 1100-1272), MERNUM MER0002195
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00116
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.66
Enzymology	BRENDA database
Proteolytic events	CutDB database (4 cleavages)
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/eh/L/QeG/Pq/e/ds (based on 11 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	9	1	0	1
Pro	0	0	1	0	0	7	1	1
Ala	2	0	0	0	1	0	1	0
Val	1	0	1	0	0	0	0	0
Leu	1	0	7	0	0	0	0	1
Ile	1	1	0	0	0	0	0	0
Met	1	0	0	0	0	0	0	0
Phe	2	0	1	0	0	0	0	0
Tyr	3	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	1	0	0	0	0	0	2
Thr	0	1	1	0	1	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	1	0
Gln	0	0	0	8	0	2	0	0
Asp	0	0	0	0	0	0	1	5
Glu	0	4	0	3	0	0	6	0
Lys	0	1	0	0	0	1	1	0
Arg	0	0	0	0	0	0	0	1
His	0	3	0	0	0	0	0	0