Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C37.001: calicivirin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Pham,S., Zhao,B., Neetu,N., Sankaran,B., Patil,K., Ramani,S., Song,Y., Estes,M.K., Palzkill,T. and Prasad,B.V.V.
    Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors
    J Virol (2025) , e0175724-e0175724. PubMed  Europe PubMed DOI  I
    2. 2023
  2. Behmard,E., Ghasemian,A., Barzegari,E., Farjadfar,A., Kouhpayeh,A. and Najafipour,S.
    Advanced simulations and screening to repurposing a 3C protease inhibitor against the rupintrivir-resistant human norovirus-induced gastroenteritis
    J Mol Graph Model (2023) 118, 108345-108345. PubMed  Europe PubMed DOI  I
  3. Eruera,A.R., McSweeney,A.M., McKenzie-Goldsmith,G.M., Opel-Reading,H.K., Thomas,S.X., Campbell,A.C., Stubbing,L., Siow,A., Hubert,J.G., Brimble,M.A., Ward,V.K. and Krause,K.L.
    Crystal Structure of Inhibitor-Bound GII.4 Sydney 2012 Norovirus 3C-Like Protease
    Viruses (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC  I
  4. Ling,C., Jin,Z., Yeung,J., da Silva,E.B., Chang,Y.C., He,T., Yim,W., O'Donoghue,A.J. and Jokerst,J.V.
    Valence-driven colorimetric detection of norovirus protease via peptide-AuNP interactions
    Chem Commun (Camb) (2023) 59, 12459-12462. PubMed  Europe PubMed DOI
  5. Yeung,J., Jin,Z., Ling,C., Retout,M., Barbosa da Silva,E., Damani,M., Chang,Y.C., Yim,W., O'Donoghue,A.J. and Jokerst,J.V.
    An approach to zwitterionic peptide design for colorimetric detection of the Southampton norovirus SV3CP protease
    Analyst (2023) 148, 4504-4512. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2022
  6. Luptak,J., Mallery,D.L., Jahun,A.S., Albecka,A., Clift,D., Ather,O., Slodkowicz,G., Goodfellow,I. and James,L.C.
    TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing
    Viruses (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  7. Zhang,H., Jiang,P., Chen,Z., Wang,D., Zhou,Y., Zhu,X., Xiao,S. and Fang,L.
    Norovirus 3C-Like protease antagonizes interferon-beta production by cleaving NEMO
    Virology (2022) 571, 12-20. PubMed  Europe PubMed DOI
    8. 2021
  8. Van Dycke,J., Dai,W., Stylianidou,Z., Li,J., Cuvry,A., Roux,E., Li,B., Rymenants,J., Bervoets,L., de Witte,P., Liu,H., Neyts,J. and Rocha-Pereira,J.
    A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo
    Viruses (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC  I
  9. Zhao,B., Hu,L., Song,Y., Patil,K., Ramani,S., Atmar,R.L., Estes,M.K. and Prasad,B.V.V.
    Norovirus Protease Structure and Antivirals Development
    Viruses (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2020
  10. Guo,J., Douangamath,A., Song,W., Coker,A.R., Chan,A.W.E., Wood,S.P., Cooper,J.B., Resnick,E., London,N. and Delft,F.V.
    In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors
    J Struct Biol X (2020) 4, 100031-100031. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Rathnayake,A.D., Kim,Y., Dampalla,C.S., Nguyen,H.N., Jesri,A.M., Kashipathy,M.M., Lushington,G.H., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C.
    Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease
    J Med Chem (2020) 63, 11945-11963. PubMed  Europe PubMed DOI
    12. 2019
  12. Chang,K.O., Kim,Y., Lovell,S., Rathnayake,A.D. and Groutas,W.C.
    Antiviral drug discovery: norovirus proteases and development of inhibitors
    Viruses (2019) 11 PubMed  Europe PubMed DOI  I
  13. Emmott,E., de Rougemont,A., Hosmillo,M., Lu,J., Fitzmaurice,T., Haas,J. and Goodfellow,I.
    Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity
    J Biol Chem (2019) 294, 4259-4271. PubMed  Europe PubMed DOI
  14. Galasiti Kankanamalage,A.C., Weerawarna,P.M., Rathnayake,A.D., Kim,Y., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C.
    Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease
    Proteins (2019) 87, 579-587. PubMed  Europe PubMed DOI  S  I
  15. Muzzarelli,K.M., Kuiper,B., Spellmon,N., Brunzelle,J., Hackett,J., Amblard,F., Zhou,S., Liu,P., Kovari,I.A., Yang,Z., Schinazi,R.F. and Kovari,L.C.
    Structural and antiviral studies of the human norovirus GII.4 protease
    Biochemistry (2019) 58, 900-907. PubMed  Europe PubMed DOI  S
  16. Ozaki,K., Matsushima,Y., Nagasawa,K., Aso,J., Saraya,T., Yoshihara,K., Murakami,K., Motoya,T., Ryo,A., Kuroda,M., Katayama,K. and Kimura,H.
    Molecular evolution of the protease region in norovirus genogroup II
    Front Microbiol (2019) 10, 2991-2991. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Viskovska,M.A., Zhao,B., Shanker,S., Choi,J.M., Deng,L., Song,Y., Palzkill,T., Hu,L., Estes,M.K. and Prasad,B.V.V.
    GII.4 Norovirus protease shows pH-sensitive proteolysis with a unique Arg-His pairing in the catalytic site
    J Virol (2019) 93, e01479-18-e01479-18. PubMed  Europe PubMed DOI  S
    18. 2018
  18. Amblard,F., Zhou,S., Liu,P., Yoon,J., Cox,B., Muzzarelli,K., Kuiper,B.D., Kovari,L.C. and Schinazi,R.F.
    Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors
    Bioorg Med Chem Lett (2018) 28, 2165-2170. PubMed  Europe PubMed DOI  I
  19. Damalanka,V.C., Kim,Y., Galasiti Kankanamalage,A.C., Rathnayake,A.D., Mehzabeen,N., Battaile,K.P., Lovell,S., Nguyen,H.N., Lushington,G.H., Chang,K.O. and Groutas,W.C.
    Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease
    Eur J Med Chem (2018) 143, 881-890. PubMed  Europe PubMed DOI  I
  20. Kitano,M., Hosmillo,M., Emmott,E., Lu,J. and Goodfellow,I.
    Selection and characterization of rupintrivir-resistant Norwalk virus replicon cells in vitro
    Antimicrob Agents Chemother (2018) 62, e00201-18-e00201-18. PubMed  Europe PubMed DOI  A  I
  21. Kuiper,B.D., Muzzarelli,K.M., Keusch,B.J., Holcomb,J., Amblard,F., Liu,P., Zhou,S., Kovari,I.A., Yang,Z., Schinazi,R.F. and Kovari,L.C.
    Expression, purification and characterization of a GII.4 norovirus protease from Minerva virus
    Infect Disord Drug Targets (2018) 18, 224-232. PubMed  Europe PubMed DOI  A  E  I
    22. 2017
  22. Damalanka,V.C., Kim,Y., Galasiti Kankanamalage,A.C., Lushington,G.H., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C.
    Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease
    Eur J Med Chem (2017) 127, 41-61. PubMed  Europe PubMed DOI  I
  23. Galasiti Kankanamalage,A.C., Kim,Y., Rathnayake,A.D., Damalanka,V.C., Weerawarna,P.M., Doyle,S.T., Alsoudi,A.F., Dissanayake,D.M., Lushington,G.H., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C.
    Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors
    Eur J Med Chem (2017) 126, 502-516. PubMed  Europe PubMed DOI  P
  24. Galasiti Kankanamalage,A.C., Kim,Y., Rathnayake,A.D., Alliston,K.R., Butler,M.M., Cardinale,S.C., Bowlin,T.L., Groutas,W.C. and Chang,K.O.
    Design, synthesis, and evaluation of novel prodrugs of transition state inhibitors of norovirus 3CL protease
    J Med Chem (2017) 60, 6239-6248. PubMed  Europe PubMed DOI  I
    25. 2016
  25. Damalanka,V.C., Kim,Y., Alliston,K.R., Weerawarna,P.M., Galasiti Kankanamalage,A.C., Lushington,G.H., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C.
    Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease
    J Med Chem (2016) 59, 1899-1913. PubMed  Europe PubMed DOI  I
  26. Weerawarna,P.M., Kim,Y., Galasiti Kankanamalage,A.C., Damalanka,V.C., Lushington,G.H., Alliston,K.R., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C.
    Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: structural, biochemical, spectroscopic, and antiviral studies
    Eur J Med Chem (2016) 119, 300-318. PubMed  Europe PubMed DOI  I
    27. 2015
  27. Emmott,E., Sweeney,T.R. and Goodfellow,I.
    A cell-based fluorescence resonance energy transfer (FRET) sensor reveals inter- and intragenogroup variations in norovirus protease activity and polyprotein cleavage
    J Biol Chem (2015) 290, 27841-27853. PubMed  Europe PubMed DOI  A
  28. Galasiti Kankanamalage,A.C., Kim,Y., Weerawarna,P.M., Uy,R.A., Damalanka,V.C., Mandadapu,S.R., Alliston,K.R., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C.
    Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies
    J Med Chem (2015) 58, 3144-3155. PubMed  Europe PubMed DOI  I
  29. Kim,Y., Galasiti Kankanamalage,A.C., Chang,K.O. and Groutas,W.C.
    Recent advances in the discovery of norovirus therapeutics
    J Med Chem (2015) 58, 9438-9450. PubMed  Europe PubMed DOI  PMC  EPMC  I
    30. 2014
  30. Herod,M.R., Prince,C.A., Skilton,R.J., Ward,V.K., Cooper,J.B. and Clarke,I.N.
    Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity
    Biochem J (2014) 464, 461-472. PubMed  Europe PubMed DOI  S
  31. May,J., Viswanathan,P., Ng,K.K., Medvedev,A. and Korba,B.
    The P4-P2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order
    J Virol (2014) 88, 10738-10747. PubMed  Europe PubMed DOI  P
  32. Qu,L., Vongpunsawad,S., Atmar,R.L., Prasad,B.V. and Estes,M.K.
    Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors
    J Virol (2014) 88, 10312-10326. PubMed  Europe PubMed DOI  A
    33. 2013
  33. Deng,L., Muhaxhiri,Z., Estes,M.K., Palzkill,T., Venkataram Prasad,B.V. and Song,Y.
    Synthesis, activity and structure-activity relationship of noroviral protease inhibitors
    MedChemComm (2013) 4, 1354-1359. PubMed  Europe PubMed DOI  I
  34. Mandadapu,S.R., Gunnam,M.R., Tiew,K.C., Uy,R.A., Prior,A.M., Alliston,K.R., Hua,D.H., Kim,Y., Chang,K.O. and Groutas,W.C.
    Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors
    Bioorg Med Chem Lett (2013) 23, 62-65. PubMed  Europe PubMed DOI  I
  35. Mandadapu,S.R., Weerawarna,P.M., Prior,A.M., Uy,R.A., Aravapalli,S., Alliston,K.R., Lushington,G.H., Kim,Y., Hua,D.H., Chang,K.O. and Groutas,W.C.
    Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus
    Bioorg Med Chem Lett (2013) 23, 3709-3712. PubMed  Europe PubMed DOI  I
  36. May,J., Korba,B., Medvedev,A. and Viswanathan,P.
    Enzyme kinetics of the human norovirus protease control virus polyprotein processing order
    Virology (2013) 444, 218-224. PubMed  Europe PubMed DOI  P
  37. Muhaxhiri,Z., Deng,L., Shanker,S., Sankaran,B., Estes,M.K., Palzkill,T., Song,Y. and Prasad,B.V.
    Structural basis of substrate specificity and protease inhibition in Norwalk virus
    J Virol (2013) 87, 4281-4292. PubMed  Europe PubMed DOI  S  I
  38. Prior,A.M., Kim,Y., Weerasekara,S., Moroze,M., Alliston,K.R., Uy,R.A., Groutas,W.C., Chang,K.O. and Hua,D.H.
    Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors
    Bioorg Med Chem Lett (2013) 23, 6317-6320. PubMed  Europe PubMed DOI  I
  39. Takahashi,D., Hiromasa,Y., Kim,Y., Anbanandam,A., Yao,X., Chang,K.O. and Prakash,O.
    Structural and dynamics characterization of norovirus protease
    Protein Sci (2013) 22, 347-357. PubMed  Europe PubMed DOI  S
  40. Takahashi,D., Kim,Y., Lovell,S., Prakash,O., Groutas,W.C. and Chang,K.O.
    Structural and inhibitor studies of norovirus 3C-like proteases
    Virus Res (2013) 178, 437-444. PubMed  Europe PubMed DOI  S  I
  41. Viswanathan,P., May,J., Uhm,S., Yon,C. and Korba,B.
    RNA binding by human norovirus 3C-like proteases inhibits protease activity
    Virology (2013) 438, 20-27. PubMed  Europe PubMed DOI
    42. 2012
  42. Chang,K.O., Takahashi,D., Prakash,O. and Kim,Y.
    Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay
    Virology (2012) 423, 125-133. PubMed  Europe PubMed DOI  A  I
  43. Mandadapu,S.R., Weerawarna,P.M., Gunnam,M.R., Alliston,K.R., Lushington,G.H., Kim,Y., Chang,K.O. and Groutas,W.C.
    Potent inhibition of norovirus 3CL protease by peptidyl alpha-ketoamides and alpha-ketoheterocycles
    Bioorg Med Chem Lett (2012) 22, 4820-4826. PubMed  Europe PubMed DOI  I
  44. Meyers,G.
    Calicivirus endopeptidases
    [ISSN:978-0-12-407743-0] (2012) 3, 2432-2436. DOI
  45. Someya,Y.
    From head to toe of the norovirus 3C-like protease
    Biomol Concepts (2012) 3, 41-56. PubMed  Europe PubMed DOI  S
  46. Takahashi,D., Kim,Y., Chang,K.O., Anbanandam,A. and Prakash,O.
    Backbone and side-chain 1H, 15N, and 13C resonance assignments of Norwalk virus protease
    Biomol NMR Assign (2012) 6, 19-21. PubMed  Europe PubMed DOI  S  T
    47. 2011
  47. Hussey,R.J., Coates,L., Gill,R.S., Erskine,P.T., Coker,S.F., Mitchell,E., Cooper,J.B., Wood,S., Broadbridge,R., Clarke,I.N., Lambden,P.R. and Shoolingin-Jordan,P.M.
    A structural study of norovirus 3C protease specificity: binding of a designed active site-directed peptide inhibitor
    Biochemistry (2011) 50, 240-249. PubMed  Europe PubMed DOI  P  S  I
  48. Oka,T., Murakami,K., Wakita,T. and Katayama,K.
    Comparative site-directed mutagenesis in the catalytic amino acid triad in calicivirus proteases
    Microbiol Immunol (2011) 55, 108-114. PubMed  Europe PubMed DOI
  49. Someya,Y. and Takeda,N.
    Functional consequences of mutational analysis of norovirus protease
    FEBS Lett (2011) 585, 369-374. PubMed  Europe PubMed DOI
  50. Tiew,K.C., He,G., Aravapalli,S., Mandadapu,S.R., Gunnam,M.R., Alliston,K.R., Lushington,G.H., Kim,Y., Chang,K.O. and Groutas,W.C.
    Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease
    Bioorg Med Chem Lett (2011) 21, 5315-5319. PubMed  Europe PubMed DOI  I
    51. 2010
  51. Hussey,R.J., Coates,L., Gill,R.S., Wright,J.N., Sarwar,M., Coker,S., Erskine,P.T., Cooper,J.B., Wood,S., Clarke,I.N., Lambden,P.R., Broadbridge,R. and Shoolingin-Jordan,P.M.
    Crystallization and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michael acceptor inhibitor
    Acta Crystallograph Sect F Struct Biol Cryst Commun (2010) 66, 1544-1548. PubMed  Europe PubMed DOI  I
    52. 2009
  52. Oka,T., Yokoyama,M., Katayama,K., Tsunemitsu,H., Yamamoto,M., Miyashita,K., Ogawa,S., Motomura,K., Mori,H., Nakamura,H., Wakita,T., Takeda,N. and Sato,H.
    Structural and biological constraints on diversity of regions immediately upstream of cleavage sites in calicivirus precursor proteins
    Virology (2009) 394, 119-129. PubMed  Europe PubMed DOI
  53. Someya,Y. and Takeda,N.
    Insights into the enzyme-substrate interaction in the norovirus 3C-like protease
    J Biochem (2009) 146, 509-521. PubMed  Europe PubMed DOI
    54. 2008
  54. Someya,Y., Takeda,N. and Wakita,T.
    Saturation mutagenesis reveals that Glu54 of norovirus 3C-like protease is not essential for the proteolytic activity
    J Biochem (2008) 144, 771-780. PubMed  Europe PubMed DOI
    55. 2007
  55. Scheffler,U., Rudolph,W., Gebhardt,J. and Rohayem,J.
    Differential cleavage of the norovirus polyprotein precursor by two active forms of the viral protease
    J Gen Virol (2007) 88, 2013-2018. PubMed  Europe PubMed DOI  P
    56. 2006
  56. Zeitler,C.E., Estes,M.K. and Venkataram Prasad,B.V.
    X-ray crystallographic structure of the Norwalk virus protease at 1.5-a resolution
    J Virol (2006) 80, 5050-5058. PubMed  Europe PubMed DOI  PMC  EPMC  S
    57. 2005
  57. Nakamura,K., Someya,Y., Kumasaka,T., Ueno,G., Yamamoto,M., Sato,T., Takeda,N., Miyamura,T. and Tanaka,N.
    A norovirus protease structure provides insights into active and substrate binding site integrity
    J Virol (2005) 79, 13685-13693. PubMed  Europe PubMed DOI  PMC  EPMC  S
  58. Someya,Y., Takeda,N. and Miyamura,T.
    Characterization of the norovirus 3C-like protease
    Virus Res (2005) 110, 91-97. PubMed  Europe PubMed DOI
    59. 2004
  59. Meyers,G., Rossi,C. and Thiel,H.J.
    Calicivirus endopeptidases
    [ISSN:0-12-079610-4] (2004) 2, 1380-1382.  V
    60. 2003
  60. Belliot,G., Sosnovtsev,S.V., Mitra,T., Hammer,C., Garfield,M. and Green,K.Y.
    In vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells
    J Virol (2003) 77, 10957-10974. PubMed  Europe PubMed DOI  PMC  EPMC
  61. [YEAR:10-4-2003]Blakeney,S.J., Cahill,A. and Reilly,P.A.
    Processing of Norwalk virus nonstructural proteins by a 3C-like cysteine proteinase
    Virology (10-4-2003) 308, 216-224. PubMed  Europe PubMed DOI
  62. Seah,E.L., Marshall,J.A. and Wright,P.J.
    Trans activity of the norovirus Camberwell proteinase and cleavage of the N-terminal protein encoded by ORF1
    J Virol (2003) 77, 7150-7155. PubMed  Europe PubMed DOI  PMC  EPMC
    63. 2002
  63. Hardy,M.E., Crone,T.J., Brower,J.E. and Ettayebi,K.
    Substrate specificity of the Norwalk virus 3C-like proteinase
    Virus Res (2002) 89, 29-39. PubMed  Europe PubMed DOI  P
  64. Someya,Y., Takeda,N. and Miyamura,T.
    Identification of active-site amino acid residues in the Chiba virus 3C-like protease
    J Virol (2002) 76, 5949-5958. PubMed  Europe PubMed DOI  PMC  EPMC
    65. 2000
  65. [YEAR:20-12-2000]Someya,Y., Takeda,N. and Miyamura,T.
    Complete nucleotide sequence of the Chiba virus genome and functional expression of the 3C-like protease in Escherichia coli
    Virology (20-12-2000) 278, 490-500. PubMed  Europe PubMed DOI
    66. 1999
  66. Liu,B.L., Viljoen,G.J., Clarke,I.N. and Lambden,P.R.
    Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli
    J Gen Virol (1999) 80, 291-296. PubMed  Europe PubMed  E
    67. 1996
  67. Liu,B., Clarke,I.N. and Lambden,P.R.
    Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis
    J Virol (1996) 70, 2605-2610. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use