Literature for peptidase C37.001: calicivirin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Pham,S., Zhao,B., Neetu,N., Sankaran,B., Patil,K., Ramani,S., Song,Y., Estes,M.K., Palzkill,T. and Prasad,B.V.V. Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors J Virol (2025) , e0175724-e0175724. PubMed Europe PubMed DOI I

2023

Behmard,E., Ghasemian,A., Barzegari,E., Farjadfar,A., Kouhpayeh,A. and Najafipour,S. Advanced simulations and screening to repurposing a 3C protease inhibitor against the rupintrivir-resistant human norovirus-induced gastroenteritis J Mol Graph Model (2023) 118, 108345-108345. PubMed Europe PubMed DOI I
Eruera,A.R., McSweeney,A.M., McKenzie-Goldsmith,G.M., Opel-Reading,H.K., Thomas,S.X., Campbell,A.C., Stubbing,L., Siow,A., Hubert,J.G., Brimble,M.A., Ward,V.K. and Krause,K.L. Crystal Structure of Inhibitor-Bound GII.4 Sydney 2012 Norovirus 3C-Like Protease Viruses (2023) 15 PubMed Europe PubMed DOI PMC EPMC I
Ling,C., Jin,Z., Yeung,J., da Silva,E.B., Chang,Y.C., He,T., Yim,W., O'Donoghue,A.J. and Jokerst,J.V. Valence-driven colorimetric detection of norovirus protease via peptide-AuNP interactions Chem Commun (Camb) (2023) 59, 12459-12462. PubMed Europe PubMed DOI
Yeung,J., Jin,Z., Ling,C., Retout,M., Barbosa da Silva,E., Damani,M., Chang,Y.C., Yim,W., O'Donoghue,A.J. and Jokerst,J.V. An approach to zwitterionic peptide design for colorimetric detection of the Southampton norovirus SV3CP protease Analyst (2023) 148, 4504-4512. PubMed Europe PubMed DOI PMC EPMC

2022

Luptak,J., Mallery,D.L., Jahun,A.S., Albecka,A., Clift,D., Ather,O., Slodkowicz,G., Goodfellow,I. and James,L.C. TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing Viruses (2022) 14 PubMed Europe PubMed DOI PMC EPMC
Zhang,H., Jiang,P., Chen,Z., Wang,D., Zhou,Y., Zhu,X., Xiao,S. and Fang,L. Norovirus 3C-Like protease antagonizes interferon-beta production by cleaving NEMO Virology (2022) 571, 12-20. PubMed Europe PubMed DOI

2021

Van Dycke,J., Dai,W., Stylianidou,Z., Li,J., Cuvry,A., Roux,E., Li,B., Rymenants,J., Bervoets,L., de Witte,P., Liu,H., Neyts,J. and Rocha-Pereira,J. A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo Viruses (2021) 13 PubMed Europe PubMed DOI PMC EPMC I
Zhao,B., Hu,L., Song,Y., Patil,K., Ramani,S., Atmar,R.L., Estes,M.K. and Prasad,B.V.V. Norovirus Protease Structure and Antivirals Development Viruses (2021) 13 PubMed Europe PubMed DOI PMC EPMC

2020

Guo,J., Douangamath,A., Song,W., Coker,A.R., Chan,A.W.E., Wood,S.P., Cooper,J.B., Resnick,E., London,N. and Delft,F.V. In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors J Struct Biol X (2020) 4, 100031-100031. PubMed Europe PubMed DOI PMC EPMC
Rathnayake,A.D., Kim,Y., Dampalla,C.S., Nguyen,H.N., Jesri,A.M., Kashipathy,M.M., Lushington,G.H., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C. Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease J Med Chem (2020) 63, 11945-11963. PubMed Europe PubMed DOI

2019

Chang,K.O., Kim,Y., Lovell,S., Rathnayake,A.D. and Groutas,W.C. Antiviral drug discovery: norovirus proteases and development of inhibitors Viruses (2019) 11 PubMed Europe PubMed DOI I
Emmott,E., de Rougemont,A., Hosmillo,M., Lu,J., Fitzmaurice,T., Haas,J. and Goodfellow,I. Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity J Biol Chem (2019) 294, 4259-4271. PubMed Europe PubMed DOI
Galasiti Kankanamalage,A.C., Weerawarna,P.M., Rathnayake,A.D., Kim,Y., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C. Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease Proteins (2019) 87, 579-587. PubMed Europe PubMed DOI S I
Muzzarelli,K.M., Kuiper,B., Spellmon,N., Brunzelle,J., Hackett,J., Amblard,F., Zhou,S., Liu,P., Kovari,I.A., Yang,Z., Schinazi,R.F. and Kovari,L.C. Structural and antiviral studies of the human norovirus GII.4 protease Biochemistry (2019) 58, 900-907. PubMed Europe PubMed DOI S
Ozaki,K., Matsushima,Y., Nagasawa,K., Aso,J., Saraya,T., Yoshihara,K., Murakami,K., Motoya,T., Ryo,A., Kuroda,M., Katayama,K. and Kimura,H. Molecular evolution of the protease region in norovirus genogroup II Front Microbiol (2019) 10, 2991-2991. PubMed Europe PubMed DOI PMC EPMC
Viskovska,M.A., Zhao,B., Shanker,S., Choi,J.M., Deng,L., Song,Y., Palzkill,T., Hu,L., Estes,M.K. and Prasad,B.V.V. GII.4 Norovirus protease shows pH-sensitive proteolysis with a unique Arg-His pairing in the catalytic site J Virol (2019) 93, e01479-18-e01479-18. PubMed Europe PubMed DOI S

2018

Amblard,F., Zhou,S., Liu,P., Yoon,J., Cox,B., Muzzarelli,K., Kuiper,B.D., Kovari,L.C. and Schinazi,R.F. Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors Bioorg Med Chem Lett (2018) 28, 2165-2170. PubMed Europe PubMed DOI I
Damalanka,V.C., Kim,Y., Galasiti Kankanamalage,A.C., Rathnayake,A.D., Mehzabeen,N., Battaile,K.P., Lovell,S., Nguyen,H.N., Lushington,G.H., Chang,K.O. and Groutas,W.C. Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease Eur J Med Chem (2018) 143, 881-890. PubMed Europe PubMed DOI I
Kitano,M., Hosmillo,M., Emmott,E., Lu,J. and Goodfellow,I. Selection and characterization of rupintrivir-resistant Norwalk virus replicon cells in vitro Antimicrob Agents Chemother (2018) 62, e00201-18-e00201-18. PubMed Europe PubMed DOI A I
Kuiper,B.D., Muzzarelli,K.M., Keusch,B.J., Holcomb,J., Amblard,F., Liu,P., Zhou,S., Kovari,I.A., Yang,Z., Schinazi,R.F. and Kovari,L.C. Expression, purification and characterization of a GII.4 norovirus protease from Minerva virus Infect Disord Drug Targets (2018) 18, 224-232. PubMed Europe PubMed DOI A E I

2017

Damalanka,V.C., Kim,Y., Galasiti Kankanamalage,A.C., Lushington,G.H., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C. Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease Eur J Med Chem (2017) 127, 41-61. PubMed Europe PubMed DOI I
Galasiti Kankanamalage,A.C., Kim,Y., Rathnayake,A.D., Damalanka,V.C., Weerawarna,P.M., Doyle,S.T., Alsoudi,A.F., Dissanayake,D.M., Lushington,G.H., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C. Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors Eur J Med Chem (2017) 126, 502-516. PubMed Europe PubMed DOI P
Galasiti Kankanamalage,A.C., Kim,Y., Rathnayake,A.D., Alliston,K.R., Butler,M.M., Cardinale,S.C., Bowlin,T.L., Groutas,W.C. and Chang,K.O. Design, synthesis, and evaluation of novel prodrugs of transition state inhibitors of norovirus 3CL protease J Med Chem (2017) 60, 6239-6248. PubMed Europe PubMed DOI I

2016

Damalanka,V.C., Kim,Y., Alliston,K.R., Weerawarna,P.M., Galasiti Kankanamalage,A.C., Lushington,G.H., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C. Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease J Med Chem (2016) 59, 1899-1913. PubMed Europe PubMed DOI I
Weerawarna,P.M., Kim,Y., Galasiti Kankanamalage,A.C., Damalanka,V.C., Lushington,G.H., Alliston,K.R., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C. Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: structural, biochemical, spectroscopic, and antiviral studies Eur J Med Chem (2016) 119, 300-318. PubMed Europe PubMed DOI I

2015

Emmott,E., Sweeney,T.R. and Goodfellow,I. A cell-based fluorescence resonance energy transfer (FRET) sensor reveals inter- and intragenogroup variations in norovirus protease activity and polyprotein cleavage J Biol Chem (2015) 290, 27841-27853. PubMed Europe PubMed DOI A
Galasiti Kankanamalage,A.C., Kim,Y., Weerawarna,P.M., Uy,R.A., Damalanka,V.C., Mandadapu,S.R., Alliston,K.R., Mehzabeen,N., Battaile,K.P., Lovell,S., Chang,K.O. and Groutas,W.C. Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies J Med Chem (2015) 58, 3144-3155. PubMed Europe PubMed DOI I
Kim,Y., Galasiti Kankanamalage,A.C., Chang,K.O. and Groutas,W.C. Recent advances in the discovery of norovirus therapeutics J Med Chem (2015) 58, 9438-9450. PubMed Europe PubMed DOI PMC EPMC I

2014

Herod,M.R., Prince,C.A., Skilton,R.J., Ward,V.K., Cooper,J.B. and Clarke,I.N. Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity Biochem J (2014) 464, 461-472. PubMed Europe PubMed DOI S
May,J., Viswanathan,P., Ng,K.K., Medvedev,A. and Korba,B. The P4-P2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order J Virol (2014) 88, 10738-10747. PubMed Europe PubMed DOI P
Qu,L., Vongpunsawad,S., Atmar,R.L., Prasad,B.V. and Estes,M.K. Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors J Virol (2014) 88, 10312-10326. PubMed Europe PubMed DOI A

2013

Deng,L., Muhaxhiri,Z., Estes,M.K., Palzkill,T., Venkataram Prasad,B.V. and Song,Y. Synthesis, activity and structure-activity relationship of noroviral protease inhibitors MedChemComm (2013) 4, 1354-1359. PubMed Europe PubMed DOI I
Mandadapu,S.R., Gunnam,M.R., Tiew,K.C., Uy,R.A., Prior,A.M., Alliston,K.R., Hua,D.H., Kim,Y., Chang,K.O. and Groutas,W.C. Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors Bioorg Med Chem Lett (2013) 23, 62-65. PubMed Europe PubMed DOI I
Mandadapu,S.R., Weerawarna,P.M., Prior,A.M., Uy,R.A., Aravapalli,S., Alliston,K.R., Lushington,G.H., Kim,Y., Hua,D.H., Chang,K.O. and Groutas,W.C. Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus Bioorg Med Chem Lett (2013) 23, 3709-3712. PubMed Europe PubMed DOI I
May,J., Korba,B., Medvedev,A. and Viswanathan,P. Enzyme kinetics of the human norovirus protease control virus polyprotein processing order Virology (2013) 444, 218-224. PubMed Europe PubMed DOI P
Muhaxhiri,Z., Deng,L., Shanker,S., Sankaran,B., Estes,M.K., Palzkill,T., Song,Y. and Prasad,B.V. Structural basis of substrate specificity and protease inhibition in Norwalk virus J Virol (2013) 87, 4281-4292. PubMed Europe PubMed DOI S I
Prior,A.M., Kim,Y., Weerasekara,S., Moroze,M., Alliston,K.R., Uy,R.A., Groutas,W.C., Chang,K.O. and Hua,D.H. Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors Bioorg Med Chem Lett (2013) 23, 6317-6320. PubMed Europe PubMed DOI I
Takahashi,D., Hiromasa,Y., Kim,Y., Anbanandam,A., Yao,X., Chang,K.O. and Prakash,O. Structural and dynamics characterization of norovirus protease Protein Sci (2013) 22, 347-357. PubMed Europe PubMed DOI S
Takahashi,D., Kim,Y., Lovell,S., Prakash,O., Groutas,W.C. and Chang,K.O. Structural and inhibitor studies of norovirus 3C-like proteases Virus Res (2013) 178, 437-444. PubMed Europe PubMed DOI S I
Viswanathan,P., May,J., Uhm,S., Yon,C. and Korba,B. RNA binding by human norovirus 3C-like proteases inhibits protease activity Virology (2013) 438, 20-27. PubMed Europe PubMed DOI

2012

Chang,K.O., Takahashi,D., Prakash,O. and Kim,Y. Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay Virology (2012) 423, 125-133. PubMed Europe PubMed DOI A I
Mandadapu,S.R., Weerawarna,P.M., Gunnam,M.R., Alliston,K.R., Lushington,G.H., Kim,Y., Chang,K.O. and Groutas,W.C. Potent inhibition of norovirus 3CL protease by peptidyl alpha-ketoamides and alpha-ketoheterocycles Bioorg Med Chem Lett (2012) 22, 4820-4826. PubMed Europe PubMed DOI I
Meyers,G. Calicivirus endopeptidases [ISSN:978-0-12-407743-0] (2012) 3, 2432-2436. DOI
Someya,Y. From head to toe of the norovirus 3C-like protease Biomol Concepts (2012) 3, 41-56. PubMed Europe PubMed DOI S
Takahashi,D., Kim,Y., Chang,K.O., Anbanandam,A. and Prakash,O. Backbone and side-chain 1H, 15N, and 13C resonance assignments of Norwalk virus protease Biomol NMR Assign (2012) 6, 19-21. PubMed Europe PubMed DOI S T

2011

Hussey,R.J., Coates,L., Gill,R.S., Erskine,P.T., Coker,S.F., Mitchell,E., Cooper,J.B., Wood,S., Broadbridge,R., Clarke,I.N., Lambden,P.R. and Shoolingin-Jordan,P.M. A structural study of norovirus 3C protease specificity: binding of a designed active site-directed peptide inhibitor Biochemistry (2011) 50, 240-249. PubMed Europe PubMed DOI P S I
Oka,T., Murakami,K., Wakita,T. and Katayama,K. Comparative site-directed mutagenesis in the catalytic amino acid triad in calicivirus proteases Microbiol Immunol (2011) 55, 108-114. PubMed Europe PubMed DOI
Someya,Y. and Takeda,N. Functional consequences of mutational analysis of norovirus protease FEBS Lett (2011) 585, 369-374. PubMed Europe PubMed DOI
Tiew,K.C., He,G., Aravapalli,S., Mandadapu,S.R., Gunnam,M.R., Alliston,K.R., Lushington,G.H., Kim,Y., Chang,K.O. and Groutas,W.C. Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease Bioorg Med Chem Lett (2011) 21, 5315-5319. PubMed Europe PubMed DOI I

2010

Hussey,R.J., Coates,L., Gill,R.S., Wright,J.N., Sarwar,M., Coker,S., Erskine,P.T., Cooper,J.B., Wood,S., Clarke,I.N., Lambden,P.R., Broadbridge,R. and Shoolingin-Jordan,P.M. Crystallization and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michael acceptor inhibitor Acta Crystallograph Sect F Struct Biol Cryst Commun (2010) 66, 1544-1548. PubMed Europe PubMed DOI I

2009

Oka,T., Yokoyama,M., Katayama,K., Tsunemitsu,H., Yamamoto,M., Miyashita,K., Ogawa,S., Motomura,K., Mori,H., Nakamura,H., Wakita,T., Takeda,N. and Sato,H. Structural and biological constraints on diversity of regions immediately upstream of cleavage sites in calicivirus precursor proteins Virology (2009) 394, 119-129. PubMed Europe PubMed DOI
Someya,Y. and Takeda,N. Insights into the enzyme-substrate interaction in the norovirus 3C-like protease J Biochem (2009) 146, 509-521. PubMed Europe PubMed DOI

2008

Someya,Y., Takeda,N. and Wakita,T. Saturation mutagenesis reveals that Glu54 of norovirus 3C-like protease is not essential for the proteolytic activity J Biochem (2008) 144, 771-780. PubMed Europe PubMed DOI

2007

Scheffler,U., Rudolph,W., Gebhardt,J. and Rohayem,J. Differential cleavage of the norovirus polyprotein precursor by two active forms of the viral protease J Gen Virol (2007) 88, 2013-2018. PubMed Europe PubMed DOI P

2006

Zeitler,C.E., Estes,M.K. and Venkataram Prasad,B.V. X-ray crystallographic structure of the Norwalk virus protease at 1.5-a resolution J Virol (2006) 80, 5050-5058. PubMed Europe PubMed DOI PMC EPMC S

2005

Nakamura,K., Someya,Y., Kumasaka,T., Ueno,G., Yamamoto,M., Sato,T., Takeda,N., Miyamura,T. and Tanaka,N. A norovirus protease structure provides insights into active and substrate binding site integrity J Virol (2005) 79, 13685-13693. PubMed Europe PubMed DOI PMC EPMC S
Someya,Y., Takeda,N. and Miyamura,T. Characterization of the norovirus 3C-like protease Virus Res (2005) 110, 91-97. PubMed Europe PubMed DOI

2004

Meyers,G., Rossi,C. and Thiel,H.J. Calicivirus endopeptidases [ISSN:0-12-079610-4] (2004) 2, 1380-1382. V

2003

Belliot,G., Sosnovtsev,S.V., Mitra,T., Hammer,C., Garfield,M. and Green,K.Y. In vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells J Virol (2003) 77, 10957-10974. PubMed Europe PubMed DOI PMC EPMC
[YEAR:10-4-2003]Blakeney,S.J., Cahill,A. and Reilly,P.A. Processing of Norwalk virus nonstructural proteins by a 3C-like cysteine proteinase Virology (10-4-2003) 308, 216-224. PubMed Europe PubMed DOI
Seah,E.L., Marshall,J.A. and Wright,P.J. Trans activity of the norovirus Camberwell proteinase and cleavage of the N-terminal protein encoded by ORF1 J Virol (2003) 77, 7150-7155. PubMed Europe PubMed DOI PMC EPMC

2002

Hardy,M.E., Crone,T.J., Brower,J.E. and Ettayebi,K. Substrate specificity of the Norwalk virus 3C-like proteinase Virus Res (2002) 89, 29-39. PubMed Europe PubMed DOI P
Someya,Y., Takeda,N. and Miyamura,T. Identification of active-site amino acid residues in the Chiba virus 3C-like protease J Virol (2002) 76, 5949-5958. PubMed Europe PubMed DOI PMC EPMC

2000

[YEAR:20-12-2000]Someya,Y., Takeda,N. and Miyamura,T. Complete nucleotide sequence of the Chiba virus genome and functional expression of the 3C-like protease in Escherichia coli Virology (20-12-2000) 278, 490-500. PubMed Europe PubMed DOI

1999

Liu,B.L., Viljoen,G.J., Clarke,I.N. and Lambden,P.R. Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli J Gen Virol (1999) 80, 291-296. PubMed Europe PubMed E

1996

Liu,B., Clarke,I.N. and Lambden,P.R. Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis J Virol (1996) 70, 2605-2610. PubMed Europe PubMed PMC EPMC