$VAR1 = undef;
Summary for peptidase C25.001: gingipain RgpA
| Names | |
|---|---|
| MEROPS Name | gingipain RgpA |
| Other names | 95 kDa gingipain, Arg-gingipain, argingipain, gingipain, gingipain-1, gingivain, HRgpA g.p. (Porphyromonas gingivalis), gingipain R, gingipain R1, prR1 g.p. (Porphyromonas gingivalis), prR2 g.p. (Porphyromonas gingivalis), prtH g.p. (Porphyromonas gingivalis) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan CD >> Subclan (none) >> Family C25 >> Subfamily (none) >> C25.001 |
| Holotype | gingipain RgpA (Porphyromonas gingivalis), Uniprot accession P28784 (peptidase unit: 228-578), MERNUM MER0001351 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Cysteine | ||
| Peplist | Included in the Peplist with identifier PL00111 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.37 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (17 cleavages) | ||
| Physiology | Generates host C5a, degrades complement component C3, and has other postulated roles in disease process. | ||
| Pharmaceutical relevance | Possible drug target in periodontitis. Suppression of pathogenicity of Porphyromonas gingivalis by gingipain inhibitor compounds KYT-1 and KYT-36 was described by Kadowaki et al. (2004). | ||
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | -/lp/-/R -/-/-/- (based on 26 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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