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Literature for peptidase C25.001: gingipain RgpA

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Wei,W., Sun,J., Ji,Z., Hu,J. and Jiang,Q.
    Gingipain and oncostatin M synergistically disrupt kidney tight junctions in periodontitis-associated acute kidney injury
    J Periodontol95, 867-879. PubMed  Europe PubMed DOI
    2. 2023
  2. Chen,H., Rosen,C.E., Gonzalez-Hernandez,J.A., Song,D., Potempa,J., Ring,A.M. and Palm,N.W.
    Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
    Cell186, 3095-3110. PubMed  Europe PubMed DOI
  3. Mahmud,A.S.M., Seers,C.A., Huq,N.L., Zhang,L., Butler,C.A., Moore,C., Cross,K.J. and Reynolds,E.C.
    Production and properties of adhesin-free gingipain proteinase RgpA
    Sci Rep13, 10780-10780. PubMed  Europe PubMed DOI
    4. 2022
  4. Castillo,D.M., Castillo,Y., Delgadillo,N.A., Neuta,Y., Lafaurie,G.I., Romero-Sanchez,C. and Castellanos,J.E.
    Purification of RgpA from external outer membrane vesicles of Porphyromonas gingivalis
    Anaerobe77, 102647-102647. PubMed  Europe PubMed DOI
  5. Castillo,Y., Castellanos,J.E., Lafaurie,G.I. and Castillo,D.M.
    Porphyromonas gingivalis outer membrane vesicles modulate cytokine and chemokine production by gingipain-dependent mechanisms in human macrophages
    Arch Oral Biol140, 105453-105453. PubMed  Europe PubMed DOI
  6. Chow,Y.C., Yam,H.C., Gunasekaran,B., Lai,W.Y., Wo,W.Y., Agarwal,T., Ong,Y.Y., Cheong,S.L. and Tan,S.A.
    Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases
    Front Cell Infect Microbiol12, 987683-987683. PubMed  Europe PubMed DOI
  7. Ciaston,I., Budziaszek,J., Satala,D., Potempa,B., Fuchs,A., Rapala-Kozik,M., Mizgalska,D., Dobosz,E., Lamont,R.J., Potempa,J. and Koziel,J.
    Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis
    MBio13, e0378721-e0378721. PubMed  Europe PubMed DOI
  8. Moore,C., Cheng,Y., Tjokro,N., Zhang,B., Kerr,M., Hayati,M., Chang,K.C.J., Shah,N., Chen,C. and Jokerst,J.V.
    A Photoacoustic-Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis
    Angew Chem Int Ed Engl61, e202201843-e202201843. PubMed  Europe PubMed DOI
  9. Sabbagh,M.N. and Decourt,B.
    COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease
    Expert Opin Investig Drugs31, 987-993. PubMed  Europe PubMed DOI  I
    10. 2021
  10. Movilla,S., Marti,S., Roca,M. and Moliner,V.
    Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations
    J Chem Inf Model PubMed  Europe PubMed DOI
    11. 2020
  11. Mo,W., Luo,H., Wu,J., Xu,N., Zhang,F., Qiu,Q., Zhu,W. and Liang,M.
    Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin beta3 in RAW264.7 cells
    J Mol Histol51, 147-159. PubMed  Europe PubMed DOI
  12. Nakanishi,H., Nonaka,S. and Wu,Z.
    Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer's disease
    CNS Neurol Disord Drug Targets PubMed  Europe PubMed DOI
  13. Nonaka,S. and Nakanishi,H.
    Secreted gingipains from Porphyromonas gingivalis induce microglia migration through endosomal signaling by protease-activated receptor 2
    Neurochem Int140, 104840-104840. PubMed  Europe PubMed DOI  K
  14. Nunes,J.M., Fillis,T., Page,M.J., Venter,C., Lancry,O., Kell,D.B., Windberger,U. and Pretorius,E.
    Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics
    Front Immunol11, 1551-1551. PubMed  Europe PubMed DOI
  15. Seers,C.A., Mahmud,A.S.M., Huq,N.L., Cross,K.J. and Reynolds,E.C.
    Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains
    J Oral Microbiol13, 1858001-1858001. PubMed  Europe PubMed DOI
    16. 2018
  16. Alhogail,S., Suaifan,G.A.R.Y., Bizzarro,S., Kaman,W.E., Bikker,F.J., Weber,K., Cialla-May,D., Popp,J. and Zourob,M.
    On site visual detection of Porphyromonas gingivalis related periodontitis by using a magnetic-nanobead based assay for gingipains protease biomarkers
    Mikrochim Acta185, 149-149. PubMed  Europe PubMed DOI  A
    17. 2017
  17. Kariu,T., Nakao,R., Ikeda,T., Nakashima,K., Potempa,J. and Imamura,T.
    Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids
    J Periodontal Res52, 89-96. PubMed  Europe PubMed DOI  I
    18. 2016
  18. O'Brien-Simpson,N.M., Holden,J.A., Lenzo,J.C., Tan,Y., Brammar,G.C., Walsh,K.A., Singleton,W., Orth,R.K.H., Slakeski,N., Cross,K.J., Darby,I.B., Becher,D., Rowe,T., Morelli,A.B., Hammet,A., Nash,A., Brown,A., Ma,B., Vingadassalom,D., McCluskey,J., Kleanthous,H. and Reynolds,E.C.
    A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis
    NPJ Vaccines1, 16022-16022. PubMed  Europe PubMed DOI
  19. Plaza,K., Kalinska,M., Bochenska,O., Meyer-Hoffert,U., Wu,Z., Fischer,J., Falkowski,K., Sasiadek,L., Bielecka,E., Potempa,B., Kozik,A., Potempa,J. and Kantyka,T.
    Gingipains of Porphyromonas gingivalis affect the stability and function of serine protease inhibitor of Kazal-type 6 (SPINK6), a tissue inhibitor of human kallikreins
    J Biol Chem291, 18753-18764. PubMed  Europe PubMed DOI
    20. 2015
  20. Jung,Y.J., Jun,H.K. and Choi,B.K.
    Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation
    Cell Microbiol17, 1304-1319. PubMed  Europe PubMed DOI
  21. Palm,E., Khalaf,H. and Bengtsson,T.
    Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis
    Mol Oral Microbiol30, 74-85. PubMed  Europe PubMed DOI
    22. 2014
  22. Haraguchi,A., Miura,M., Fujise,O., Hamachi,T. and Nishimura,F.
    Porphyromonas gingivalis gingipain is involved in the detachment and aggregation of Aggregatibacter actinomycetemcomitans biofilm
    Mol Oral Microbiol29, 131-143. PubMed  Europe PubMed DOI  I
  23. Kataoka,S., Baba,A., Suda,Y., Takii,R., Hashimoto,M., Kawakubo,T., Asao,T., Kadowaki,T. and Yamamoto,K.
    A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy
    FASEB J28, 3564-3578. PubMed  Europe PubMed DOI  I
  24. Taniguchi,M., Matsuhashi,Y., Abe,T.K., Ishiyama,Y., Saitoh,E., Kato,T., Ochiai,A. and Tanaka,T.
    Contribution of cationic amino acids toward the inhibition of Arg-specific cysteine proteinase (Arg-gingipain) by the antimicrobial dodecapeptide, CL(14-25), from rice protein
    Biopolymers102, 379-389. PubMed  Europe PubMed DOI  I
    25. 2013
  25. Huq,N.L., Seers,C.A., Toh,E.C., Dashper,S.G., Slakeski,N., Zhang,L., Ward,B.R., Meuric,V., Chen,D., Cross,K.J. and Reynolds,E.C.
    Propeptide-mediated inhibition of cognate gingipain proteinases
    PLoS ONE8, e65447-e65447. PubMed  Europe PubMed DOI
  26. van der Post,S., Subramani,D.B., Backstrom,M., Johansson,M.E., Vester-Christensen,M.B., Mandel,U., Bennett,E.P., Clausen,H., Dahlen,G., Sroka,A., Potempa,J. and Hansson,G.C.
    Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB)
    J Biol Chem288, 14636-14646. PubMed  Europe PubMed DOI  P
  27. Veillard,F., Sztukowska,M., Mizgalska,D., Ksiazek,M., Houston,J., Potempa,B., Enghild,J.J., Thogersen,I.B., Gomis-Ruth,F.X., Nguyen,K.A. and Potempa,J.
    Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases
    Biochim Biophys Acta Gen Subj1830, 4218-4228. PubMed  Europe PubMed DOI
  28. Zhou,X.Y., Gao,J.L., Hunter,N., Potempa,J. and Nguyen,K.A.
    Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis
    Mol Microbiol89, 903-917. PubMed  Europe PubMed DOI
    29. 2012
  29. Kaman,W.E., Galassi,F., de Soet,J.J., Bizzarro,S., Loos,B.G., Veerman,E.C., van Belkum,A., Hays,J.P. and Bikker,F.J.
    Highly specific protease-based approach for detection of Porphyromonas gingivalis in diagnosis of periodontitis
    J Clin Microbiol50, 104-112. PubMed  Europe PubMed DOI
  30. Nguyen,K.A. and Potempa,J.
    Gingipain R
    [ISSN:978-0-12-407743-0]3, 2328-2336. DOI
  31. Sztukowska,M., Veillard,F., Potempa,B., Bogyo,M., Enghild,J.J., Thogersen,I.B., Nguyen,K.A. and Potempa,J.
    Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes
    Biol Chem393, 971-977. PubMed  Europe PubMed DOI
  32. Veillard,F., Potempa,B., Poreba,M., Drag,M. and Potempa,J.
    Gingipain aminopeptidase activities in Porphyromonas gingivalis
    Biol Chem393, 1471-1476. PubMed  Europe PubMed DOI
    33. 2011
  33. Skottrup,P.D., Leonard,P., Kaczmarek,J.Z., Veillard,F., Enghild,J.J., O'Kennedy,R., Sroka,A., Clausen,R.P., Potempa,J. and Riise,E.
    Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis
    Anal Biochem415, 158-167. PubMed  Europe PubMed DOI
  34. Slakeski,N., Seers,C.A., Ng,K., Moore,C., Cleal,S.M., Veith,P.D., Lo,A.W. and Reynolds,E.C.
    C-terminal domain residues important for secretion and attachment of RgpB in Porphyromonas gingivalis
    J Bacteriol193, 132-142. PubMed  Europe PubMed DOI
  35. Smalley,J.W., Byrne,D.P., Birss,A.J., Wojtowicz,H., Sroka,A., Potempa,J. and Olczak,T.
    HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis
    PLoS ONE6, e17182-e17182. PubMed  Europe PubMed DOI
  36. Toh,E.C., Dashper,S.G., Huq,N.L., Attard,T.J., O'Brien-Simpson,N.M., Chen,Y.Y., Cross,K.J., Stanton,D.P., Paolini,R.A. and Reynolds,E.C.
    Porphyromonas gingivalis cysteine proteinase inhibition by kappa-casein peptides
    Antimicrob Agents Chemother55, 1155-1161. PubMed  Europe PubMed DOI
    37. 2010
  37. Guo,Y., Nguyen,K.A. and Potempa,J.
    Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins
    Periodontol 200054, 15-44. PubMed  Europe PubMed DOI
  38. Kim,D. and Lee,D.S.
    A computational simulation study of benzamidine derivatives binding to arginine-specific gingipain (HRgpA) from periodontopathogen Porphyromonas gingivalis
    Int J Mol Sci11, 3252-3265. PubMed  Europe PubMed DOI  I
  39. Li,N., Yun,P., Nadkarni,M.A., Ghadikolaee,N.B., Nguyen,K.A., Lee,M., Hunter,N. and Collyer,C.A.
    Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis
    Mol Microbiol76, 861-873. PubMed  Europe PubMed DOI
  40. Saiki,K. and Konishi,K.
    Identification of a novel Porphyromonas gingivalis outer membrane protein, PG534, required for the production of active gingipains
    FEMS Microbiol Lett310, 168-174. PubMed  Europe PubMed DOI
    41. 2009
  41. Fitzpatrick,R.E., Wijeyewickrema,L.C. and Pike,R.N.
    The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis
    Future Microbiol4, 471-487. PubMed  Europe PubMed DOI
  42. Inomata,M., Ishihara,Y., Matsuyama,T., Imamura,T., Maruyama,I., Noguchi,T. and Matsushita,K.
    Degradation of vascular endothelial thrombomodulin by arginine-and lysine-specific cysteine proteases from Porphyromonas gingivalis
    J Periodontol80, 1511-1517. PubMed  Europe PubMed DOI
  43. Ishiguro,I., Saiki,K. and Konishi,K.
    PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system
    FEMS Microbiol Lett292, 261-267. PubMed  Europe PubMed DOI
  44. Kantyka,T., Latendorf,T., Wiedow,O., Bartels,J., Glaser,R., Dubin,G., Schroder,J.M., Potempa,J. and Meyer-Hoffert,U.
    Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage
    Biol Chem390, 1313-1320. PubMed  Europe PubMed DOI  P
  45. Tam,V., O'Brien-Simpson,N.M., Chen,Y.Y., Sanderson,C.J., Kinnear,B. and Reynolds,E.C.
    The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis inactivate the Th2 cytokines interleukin-4 and interleukin-5
    Infect Immun77, 1451-1458. PubMed  Europe PubMed DOI
    46. 2008
  46. Bania,J., Kubiak,A., Wojtachnio,K. and Polanowski,A.
    Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis
    J Periodontal Res43, 232-236. PubMed  Europe PubMed DOI
  47. Dias,I.H., Marshall,L., Lambert,P.A., Chapple,I.L., Matthews,J.B. and Griffiths,H.R.
    Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant
    Infect Immun76, 317-323. PubMed  Europe PubMed DOI
  48. Sheets,S.M., Robles-Price,A.G., McKenzie,R.M., Casiano,C.A. and Fletcher,H.M.
    Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis
    Front Biosci13, 3215-3238. PubMed  Europe PubMed DOI  V
  49. Slaney,J.M. and Curtis,M.A.
    Mechanisms of evasion of complement by Porphyromonas gingivalis
    Front Biosci13, 188-196. PubMed  Europe PubMed DOI
    50. 2007
  50. Inomata,M., Into,T., Ishihara,Y., Nakashima,M., Noguchi,T. and Matsushita,K.
    Arginine-specific gingipain A from Porphyromonas gingivalis induces Weibel-Palade body exocytosis and enhanced activation of vascular endothelial cells through protease-activated receptors
    Microbes Infect9, 1500-1506. PubMed  Europe PubMed DOI
  51. Kadowaki,T., Takii,R., Yamatake,K., Kawakubo,T., Tsukuba,T. and Yamamoto,K.
    A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells
    Front Biosci12, 4800-4809. PubMed  Europe PubMed DOI
  52. Kato,T., Tsuda,T., Omori,H., Kato,T., Yoshimori,T. and Amano,A.
    Maturation of fimbria precursor protein by exogenous gingipains in Porphyromonas gingivalis gingipain-null mutant
    FEMS Microbiol Lett273, 96-102. PubMed  Europe PubMed DOI
  53. Nguyen,K.A., Travis,J. and Potempa,J.
    Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-negative bacteria?
    J Bacteriol189, 833-843. PubMed  Europe PubMed DOI
  54. Page,R.C., Lantz,M.S., Darveau,R., Jeffcoat,M., Mancl,L., Houston,L., Braham,P. and Persson,G.R.
    Immunization of Macaca fascicularis against experimental periodontitis using a vaccine containing cysteine proteases purified from Porphyromonas gingivalis
    Oral Microbiol Immunol22, 162-168. PubMed  Europe PubMed DOI
  55. Pathirana,R.D., O'Brien-Simpson,N.M., Brammar,G.C., Slakeski,N. and Reynolds,E.C.
    Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model
    Infect Immun75, 1436-1442. PubMed  Europe PubMed DOI
  56. Popadiak,K., Potempa,J., Riesbeck,K. and Blom,A.M.
    Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system
    J Immunol178, 7242-7250. PubMed  Europe PubMed
  57. Smalley,J.W., Birss,A.J., Szmigielski,B. and Potempa,J.
    Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin
    Arch Biochem Biophys465, 44-49. PubMed  Europe PubMed DOI  I
    58. 2006
  58. [YEAR:9-3-2006]Bialas,A., Grembecka,J., Krowarsch,D., Otlewski,J., Potempa,J. and Mucha,A.
    Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity
    J Med Chem49, 1744-1753. PubMed  Europe PubMed DOI  I
  59. Cronan,C.A., Potempa,J., Travis,J. and Mayo,J.A.
    Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II)
    Oral Microbiol Immunol21, 212-217. PubMed  Europe PubMed DOI  I
  60. Matsushita,K., Imamura,T., Tancharoen,S., Tatsuyama,S., Tomikawa,M., Travis,J., Potempa,J., Torii,M. and Maruyama,I.
    Selective inhibition of Porphyromonas gingivalis growth by a factor Xa inhibitor, DX-9065a
    J Periodontal Res41, 171-176. PubMed  Europe PubMed DOI  I
  61. Slaney,J.M., Gallagher,A., Aduse-Opoku,J., Pell,K. and Curtis,M.A.
    Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement
    Infect Immun74, 5352-5361. PubMed  Europe PubMed DOI  K
  62. Yasaki-Inagaki,Y., Inagaki,S., Yamada,S., Okuda,K. and Ishihara,K.
    Production of protective antibodies against Porphyromonas gingivalis strains by immunization with recombinant gingipain domains
    FEMS Immunol Med Microbiol47, 287-295. PubMed  Europe PubMed DOI
    63. 2005
  63. Beikler,T., Peters,U., Prior,K., Ehmke,B. and Flemmig,T.F.
    Sequence variations in rgpA and rgpB of Porphyromonas gingivalis in periodontitis
    J Periodontal Res40, 193-198. PubMed  Europe PubMed DOI
  64. Rangarajan,M., Hashim,A., Aduse-Opoku,J., Paramonov,N., Hounsell,E.F. and Curtis,M.A.
    Expression of Arg-gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50
    Infect Immun73, 4864-4878. PubMed  Europe PubMed DOI
  65. Sato,K., Sakai,E., Veith,P.D., Shoji,M., Kikuchi,Y., Yukitake,H., Ohara,N., Naito,M., Okamoto,K., Reynolds,E.C. and Nakayama,K.
    Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis
    J Biol Chem280, 8668-8677. PubMed  Europe PubMed DOI
  66. [YEAR:1-5-2005]Tancharoen,S., Sarker,K.P., Imamura,T., Biswas,K.K., Matsushita,K., Tatsuyama,S., Travis,J., Potempa,J., Torii,M. and Maruyama,I.
    Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling
    J Immunol174, 5796-5804. PubMed  Europe PubMed
  67. Yun,P.L., Decarlo,A.A., Chapple,C.C. and Hunter,N.
    Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of Porphyromonas gingivalis for the pathology of periodontal disease
    Infect Immun73, 1386-1398. PubMed  Europe PubMed DOI
    68. 2004
  68. Goulet,V., Britigan,B., Nakayama,K. and Grenier,D.
    Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals
    Infect Immun72, 4351-4356. PubMed  Europe PubMed DOI
  69. Imamura,T., Potempa,J. and Travis,J.
    Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases
    Biol Chem385, 989-996. PubMed  Europe PubMed DOI  V
  70. Imamura,T., Potempa,J. and Travis,J.
    Gingipain R
    [ISSN:0-12-079610-4]2, 1319-1328.  V
  71. [YEAR:10-9-2004]Kadowaki,T., Baba,A., Abe,N., Takii,R., Hashimoto,M., Tsukuba,T., Okazaki,S., Suda,Y., Asao,T. and Yamamoto,K.
    Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors
    Mol Pharmacol66, 1599-1606. PubMed  Europe PubMed DOI  I
  72. Liu,X., Sroka,A., Potempa,J. and Genco,C.A.
    Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR
    Biol Chem385, 1049-1057. PubMed  Europe PubMed DOI
  73. Okamoto,M., Sugimoto,A., Leung,K.P., Nakayama,K., Kamaguchi,A. and Maeda,N.
    Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis
    Oral Microbiol Immunol19, 118-120. PubMed  Europe PubMed DOI  I
  74. [YEAR:23-1-2004]Smalley,J.W., Thomas,M.F., Birss,A.J., Withnall,R. and Silver,J.
    A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
    Biochem J379, 833-840. PubMed  Europe PubMed DOI
  75. Vanterpool,E., Roy,F. and Fletcher,H.M.
    The vimE gene downstream of vimA is independently expressed and is involved in modulating proteolytic activity in Porphyromonas gingivalis W83
    Infect Immun72, 5555-5564. PubMed  Europe PubMed DOI
    76. 2003
  76. [YEAR:14-10-2003]Ally,N., Whisstock,J.C., Sieprawska-Lupa,M., Potempa,J., le Bonniec,B.F., Travis,J. and Pike,R.N.
    Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes
    Biochemistry42, 11693-11700. PubMed  Europe PubMed DOI
  77. Gallagher,A., Aduse-Opoku,J., Rangarajan,M., Slaney,J.M. and Curtis,M.A.
    Glycosylation of the Arg-gingipains of Porphyromonas gingivalis and comparison with glycoconjugate structure and synthesis in other bacteria
    Curr Protein Pept Sci4, 427-441. PubMed  Europe PubMed DOI
  78. Grenier,D., Roy,S., Chandad,F., Plamondon,P., Yoshioka,M., Nakayama,K. and Mayrand,D.
    Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis
    Infect Immun71, 4742-4748. PubMed  Europe PubMed DOI
  79. [YEAR:25-4-2003]Houle,M.A., Grenier,D., Plamondon,P. and Nakayama,K.
    The collagenase activity of Porphyromonas gingivalis is due to Arg-gingipain
    FEMS Microbiol Lett221, 181-185. PubMed  Europe PubMed DOI
  80. Imamura,T., Travis,J. and Potempa,J.
    The biphasic virulence activities of gingipains: activation and inactivation of host proteins
    Curr Protein Pept Sci4, 443-450. PubMed  Europe PubMed DOI
  81. Kamaguchi,A., Ohyama,T., Sakai,E., Nakamura,R., Watanabe,T., Baba,H. and Nakayama,K.
    Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for co-aggregation with Prevotella intermedia
    Microbiology (Reading)149, 1257-1264. PubMed  Europe PubMed DOI
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