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Literature for peptidase C25.001: gingipain RgpA

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kamio,N., Cueno,M.E., Takagi,A. and Imai,K.
    Porphyromonas gingivalis gingipain potentially activates influenza A virus infectivity through proteolytic cleavage of viral hemagglutinin
    J Biol Chem (2025) , 108166-108166. PubMed  Europe PubMed DOI
    2. 2024
  2. Wei,W., Sun,J., Ji,Z., Hu,J. and Jiang,Q.
    Gingipain and oncostatin M synergistically disrupt kidney tight junctions in periodontitis-associated acute kidney injury
    J Periodontol (2024) 95, 867-879. PubMed  Europe PubMed DOI
    3. 2023
  3. Chen,H., Rosen,C.E., Gonzalez-Hernandez,J.A., Song,D., Potempa,J., Ring,A.M. and Palm,N.W.
    Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
    Cell (2023) 186, 3095-3110. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Mahmud,A.S.M., Seers,C.A., Huq,N.L., Zhang,L., Butler,C.A., Moore,C., Cross,K.J. and Reynolds,E.C.
    Production and properties of adhesin-free gingipain proteinase RgpA
    Sci Rep (2023) 13, 10780-10780. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2022
  5. Castillo,D.M., Castillo,Y., Delgadillo,N.A., Neuta,Y., Lafaurie,G.I., Romero-Sanchez,C. and Castellanos,J.E.
    Purification of RgpA from external outer membrane vesicles of Porphyromonas gingivalis
    Anaerobe (2022) 77, 102647-102647. PubMed  Europe PubMed DOI
  6. Castillo,Y., Castellanos,J.E., Lafaurie,G.I. and Castillo,D.M.
    Porphyromonas gingivalis outer membrane vesicles modulate cytokine and chemokine production by gingipain-dependent mechanisms in human macrophages
    Arch Oral Biol (2022) 140, 105453-105453. PubMed  Europe PubMed DOI
  7. Chow,Y.C., Yam,H.C., Gunasekaran,B., Lai,W.Y., Wo,W.Y., Agarwal,T., Ong,Y.Y., Cheong,S.L. and Tan,S.A.
    Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases
    Front Cell Infect Microbiol (2022) 12, 987683-987683. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Ciaston,I., Budziaszek,J., Satala,D., Potempa,B., Fuchs,A., Rapala-Kozik,M., Mizgalska,D., Dobosz,E., Lamont,R.J., Potempa,J. and Koziel,J.
    Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis
    MBio (2022) 13, e0378721-e0378721. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Moore,C., Cheng,Y., Tjokro,N., Zhang,B., Kerr,M., Hayati,M., Chang,K.C.J., Shah,N., Chen,C. and Jokerst,J.V.
    A Photoacoustic-Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis
    Angew Chem Int Ed Engl (2022) 61, e202201843-e202201843. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Sabbagh,M.N. and Decourt,B.
    COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease
    Expert Opin Investig Drugs (2022) 31, 987-993. PubMed  Europe PubMed DOI  I
    11. 2021
  11. Movilla,S., Marti,S., Roca,M. and Moliner,V.
    Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations
    J Chem Inf Model (2021) PubMed  Europe PubMed DOI
    12. 2020
  12. Mo,W., Luo,H., Wu,J., Xu,N., Zhang,F., Qiu,Q., Zhu,W. and Liang,M.
    Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin beta3 in RAW264.7 cells
    J Mol Histol (2020) 51, 147-159. PubMed  Europe PubMed DOI
  13. Nakanishi,H., Nonaka,S. and Wu,Z.
    Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer's disease
    CNS Neurol Disord Drug Targets (2020) PubMed  Europe PubMed DOI
  14. Nonaka,S. and Nakanishi,H.
    Secreted gingipains from Porphyromonas gingivalis induce microglia migration through endosomal signaling by protease-activated receptor 2
    Neurochem Int (2020) 140, 104840-104840. PubMed  Europe PubMed DOI  K
  15. Nunes,J.M., Fillis,T., Page,M.J., Venter,C., Lancry,O., Kell,D.B., Windberger,U. and Pretorius,E.
    Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics
    Front Immunol (2020) 11, 1551-1551. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Seers,C.A., Mahmud,A.S.M., Huq,N.L., Cross,K.J. and Reynolds,E.C.
    Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains
    J Oral Microbiol (2020) 13, 1858001-1858001. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2018
  17. Alhogail,S., Suaifan,G.A.R.Y., Bizzarro,S., Kaman,W.E., Bikker,F.J., Weber,K., Cialla-May,D., Popp,J. and Zourob,M.
    On site visual detection of Porphyromonas gingivalis related periodontitis by using a magnetic-nanobead based assay for gingipains protease biomarkers
    Mikrochim Acta (2018) 185, 149-149. PubMed  Europe PubMed DOI  A
    18. 2017
  18. Kariu,T., Nakao,R., Ikeda,T., Nakashima,K., Potempa,J. and Imamura,T.
    Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids
    J Periodontal Res (2017) 52, 89-96. PubMed  Europe PubMed DOI  I
    19. 2016
  19. O'Brien-Simpson,N.M., Holden,J.A., Lenzo,J.C., Tan,Y., Brammar,G.C., Walsh,K.A., Singleton,W., Orth,R.K.H., Slakeski,N., Cross,K.J., Darby,I.B., Becher,D., Rowe,T., Morelli,A.B., Hammet,A., Nash,A., Brown,A., Ma,B., Vingadassalom,D., McCluskey,J., Kleanthous,H. and Reynolds,E.C.
    A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis
    NPJ Vaccines (2016) 1, 16022-16022. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Plaza,K., Kalinska,M., Bochenska,O., Meyer-Hoffert,U., Wu,Z., Fischer,J., Falkowski,K., Sasiadek,L., Bielecka,E., Potempa,B., Kozik,A., Potempa,J. and Kantyka,T.
    Gingipains of Porphyromonas gingivalis affect the stability and function of serine protease inhibitor of Kazal-type 6 (SPINK6), a tissue inhibitor of human kallikreins
    J Biol Chem (2016) 291, 18753-18764. PubMed  Europe PubMed DOI
    21. 2015
  21. Jung,Y.J., Jun,H.K. and Choi,B.K.
    Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation
    Cell Microbiol (2015) 17, 1304-1319. PubMed  Europe PubMed DOI
  22. Palm,E., Khalaf,H. and Bengtsson,T.
    Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis
    Mol Oral Microbiol (2015) 30, 74-85. PubMed  Europe PubMed DOI
    23. 2014
  23. Haraguchi,A., Miura,M., Fujise,O., Hamachi,T. and Nishimura,F.
    Porphyromonas gingivalis gingipain is involved in the detachment and aggregation of Aggregatibacter actinomycetemcomitans biofilm
    Mol Oral Microbiol (2014) 29, 131-143. PubMed  Europe PubMed DOI  I
  24. Kataoka,S., Baba,A., Suda,Y., Takii,R., Hashimoto,M., Kawakubo,T., Asao,T., Kadowaki,T. and Yamamoto,K.
    A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy
    FASEB J (2014) 28, 3564-3578. PubMed  Europe PubMed DOI  I
  25. Taniguchi,M., Matsuhashi,Y., Abe,T.K., Ishiyama,Y., Saitoh,E., Kato,T., Ochiai,A. and Tanaka,T.
    Contribution of cationic amino acids toward the inhibition of Arg-specific cysteine proteinase (Arg-gingipain) by the antimicrobial dodecapeptide, CL(14-25), from rice protein
    Biopolymers (2014) 102, 379-389. PubMed  Europe PubMed DOI  I
    26. 2013
  26. Huq,N.L., Seers,C.A., Toh,E.C., Dashper,S.G., Slakeski,N., Zhang,L., Ward,B.R., Meuric,V., Chen,D., Cross,K.J. and Reynolds,E.C.
    Propeptide-mediated inhibition of cognate gingipain proteinases
    PLoS ONE (2013) 8, e65447-e65447. PubMed  Europe PubMed DOI  PMC  EPMC
  27. van der Post,S., Subramani,D.B., Backstrom,M., Johansson,M.E., Vester-Christensen,M.B., Mandel,U., Bennett,E.P., Clausen,H., Dahlen,G., Sroka,A., Potempa,J. and Hansson,G.C.
    Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB)
    J Biol Chem (2013) 288, 14636-14646. PubMed  Europe PubMed DOI  P
  28. Veillard,F., Sztukowska,M., Mizgalska,D., Ksiazek,M., Houston,J., Potempa,B., Enghild,J.J., Thogersen,I.B., Gomis-Ruth,F.X., Nguyen,K.A. and Potempa,J.
    Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases
    Biochim Biophys Acta Gen Subj (2013) 1830, 4218-4228. PubMed  Europe PubMed DOI
  29. Zhou,X.Y., Gao,J.L., Hunter,N., Potempa,J. and Nguyen,K.A.
    Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis
    Mol Microbiol (2013) 89, 903-917. PubMed  Europe PubMed DOI
    30. 2012
  30. Kaman,W.E., Galassi,F., de Soet,J.J., Bizzarro,S., Loos,B.G., Veerman,E.C., van Belkum,A., Hays,J.P. and Bikker,F.J.
    Highly specific protease-based approach for detection of Porphyromonas gingivalis in diagnosis of periodontitis
    J Clin Microbiol (2012) 50, 104-112. PubMed  Europe PubMed DOI
  31. Nguyen,K.A. and Potempa,J.
    Gingipain R
    [ISSN:978-0-12-407743-0] (2012) 3, 2328-2336. DOI
  32. Sztukowska,M., Veillard,F., Potempa,B., Bogyo,M., Enghild,J.J., Thogersen,I.B., Nguyen,K.A. and Potempa,J.
    Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes
    Biol Chem (2012) 393, 971-977. PubMed  Europe PubMed DOI
  33. Veillard,F., Potempa,B., Poreba,M., Drag,M. and Potempa,J.
    Gingipain aminopeptidase activities in Porphyromonas gingivalis
    Biol Chem (2012) 393, 1471-1476. PubMed  Europe PubMed DOI
    34. 2011
  34. Skottrup,P.D., Leonard,P., Kaczmarek,J.Z., Veillard,F., Enghild,J.J., O'Kennedy,R., Sroka,A., Clausen,R.P., Potempa,J. and Riise,E.
    Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis
    Anal Biochem (2011) 415, 158-167. PubMed  Europe PubMed DOI
  35. Slakeski,N., Seers,C.A., Ng,K., Moore,C., Cleal,S.M., Veith,P.D., Lo,A.W. and Reynolds,E.C.
    C-terminal domain residues important for secretion and attachment of RgpB in Porphyromonas gingivalis
    J Bacteriol (2011) 193, 132-142. PubMed  Europe PubMed DOI
  36. Smalley,J.W., Byrne,D.P., Birss,A.J., Wojtowicz,H., Sroka,A., Potempa,J. and Olczak,T.
    HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis
    PLoS ONE (2011) 6, e17182-e17182. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Toh,E.C., Dashper,S.G., Huq,N.L., Attard,T.J., O'Brien-Simpson,N.M., Chen,Y.Y., Cross,K.J., Stanton,D.P., Paolini,R.A. and Reynolds,E.C.
    Porphyromonas gingivalis cysteine proteinase inhibition by kappa-casein peptides
    Antimicrob Agents Chemother (2011) 55, 1155-1161. PubMed  Europe PubMed DOI
    38. 2010
  38. Guo,Y., Nguyen,K.A. and Potempa,J.
    Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins
    Periodontol 2000 (2010) 54, 15-44. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Kim,D. and Lee,D.S.
    A computational simulation study of benzamidine derivatives binding to arginine-specific gingipain (HRgpA) from periodontopathogen Porphyromonas gingivalis
    Int J Mol Sci (2010) 11, 3252-3265. PubMed  Europe PubMed DOI  PMC  EPMC  I
  40. Li,N., Yun,P., Nadkarni,M.A., Ghadikolaee,N.B., Nguyen,K.A., Lee,M., Hunter,N. and Collyer,C.A.
    Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis
    Mol Microbiol (2010) 76, 861-873. PubMed  Europe PubMed DOI
  41. Saiki,K. and Konishi,K.
    Identification of a novel Porphyromonas gingivalis outer membrane protein, PG534, required for the production of active gingipains
    FEMS Microbiol Lett (2010) 310, 168-174. PubMed  Europe PubMed DOI
    42. 2009
  42. Fitzpatrick,R.E., Wijeyewickrema,L.C. and Pike,R.N.
    The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis
    Future Microbiol (2009) 4, 471-487. PubMed  Europe PubMed DOI
  43. Inomata,M., Ishihara,Y., Matsuyama,T., Imamura,T., Maruyama,I., Noguchi,T. and Matsushita,K.
    Degradation of vascular endothelial thrombomodulin by arginine-and lysine-specific cysteine proteases from Porphyromonas gingivalis
    J Periodontol (2009) 80, 1511-1517. PubMed  Europe PubMed DOI
  44. Ishiguro,I., Saiki,K. and Konishi,K.
    PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system
    FEMS Microbiol Lett (2009) 292, 261-267. PubMed  Europe PubMed DOI
  45. Kantyka,T., Latendorf,T., Wiedow,O., Bartels,J., Glaser,R., Dubin,G., Schroder,J.M., Potempa,J. and Meyer-Hoffert,U.
    Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage
    Biol Chem (2009) 390, 1313-1320. PubMed  Europe PubMed DOI  P
  46. Tam,V., O'Brien-Simpson,N.M., Chen,Y.Y., Sanderson,C.J., Kinnear,B. and Reynolds,E.C.
    The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis inactivate the Th2 cytokines interleukin-4 and interleukin-5
    Infect Immun (2009) 77, 1451-1458. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2008
  47. Bania,J., Kubiak,A., Wojtachnio,K. and Polanowski,A.
    Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis
    J Periodontal Res (2008) 43, 232-236. PubMed  Europe PubMed DOI
  48. Dias,I.H., Marshall,L., Lambert,P.A., Chapple,I.L., Matthews,J.B. and Griffiths,H.R.
    Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant
    Infect Immun (2008) 76, 317-323. PubMed  Europe PubMed DOI  PMC  EPMC
  49. Sheets,S.M., Robles-Price,A.G., McKenzie,R.M., Casiano,C.A. and Fletcher,H.M.
    Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis
    Front Biosci (2008) 13, 3215-3238. PubMed  Europe PubMed DOI  V
  50. Slaney,J.M. and Curtis,M.A.
    Mechanisms of evasion of complement by Porphyromonas gingivalis
    Front Biosci (2008) 13, 188-196. PubMed  Europe PubMed DOI
    51. 2007
  51. Inomata,M., Into,T., Ishihara,Y., Nakashima,M., Noguchi,T. and Matsushita,K.
    Arginine-specific gingipain A from Porphyromonas gingivalis induces Weibel-Palade body exocytosis and enhanced activation of vascular endothelial cells through protease-activated receptors
    Microbes Infect (2007) 9, 1500-1506. PubMed  Europe PubMed DOI
  52. Kadowaki,T., Takii,R., Yamatake,K., Kawakubo,T., Tsukuba,T. and Yamamoto,K.
    A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells
    Front Biosci (2007) 12, 4800-4809. PubMed  Europe PubMed DOI
  53. Kato,T., Tsuda,T., Omori,H., Kato,T., Yoshimori,T. and Amano,A.
    Maturation of fimbria precursor protein by exogenous gingipains in Porphyromonas gingivalis gingipain-null mutant
    FEMS Microbiol Lett (2007) 273, 96-102. PubMed  Europe PubMed DOI
  54. Nguyen,K.A., Travis,J. and Potempa,J.
    Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-negative bacteria?
    J Bacteriol (2007) 189, 833-843. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Page,R.C., Lantz,M.S., Darveau,R., Jeffcoat,M., Mancl,L., Houston,L., Braham,P. and Persson,G.R.
    Immunization of Macaca fascicularis against experimental periodontitis using a vaccine containing cysteine proteases purified from Porphyromonas gingivalis
    Oral Microbiol Immunol (2007) 22, 162-168. PubMed  Europe PubMed DOI
  56. Pathirana,R.D., O'Brien-Simpson,N.M., Brammar,G.C., Slakeski,N. and Reynolds,E.C.
    Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model
    Infect Immun (2007) 75, 1436-1442. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Popadiak,K., Potempa,J., Riesbeck,K. and Blom,A.M.
    Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system
    J Immunol (2007) 178, 7242-7250. PubMed  Europe PubMed
  58. Smalley,J.W., Birss,A.J., Szmigielski,B. and Potempa,J.
    Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin
    Arch Biochem Biophys (2007) 465, 44-49. PubMed  Europe PubMed DOI  I
    59. 2006
  59. [YEAR:9-3-2006]Bialas,A., Grembecka,J., Krowarsch,D., Otlewski,J., Potempa,J. and Mucha,A.
    Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity
    J Med Chem (9-3-2006) 49, 1744-1753. PubMed  Europe PubMed DOI  I
  60. Cronan,C.A., Potempa,J., Travis,J. and Mayo,J.A.
    Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II)
    Oral Microbiol Immunol (2006) 21, 212-217. PubMed  Europe PubMed DOI  I
  61. Matsushita,K., Imamura,T., Tancharoen,S., Tatsuyama,S., Tomikawa,M., Travis,J., Potempa,J., Torii,M. and Maruyama,I.
    Selective inhibition of Porphyromonas gingivalis growth by a factor Xa inhibitor, DX-9065a
    J Periodontal Res (2006) 41, 171-176. PubMed  Europe PubMed DOI  I
  62. Slaney,J.M., Gallagher,A., Aduse-Opoku,J., Pell,K. and Curtis,M.A.
    Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement
    Infect Immun (2006) 74, 5352-5361. PubMed  Europe PubMed DOI  K
  63. Yasaki-Inagaki,Y., Inagaki,S., Yamada,S., Okuda,K. and Ishihara,K.
    Production of protective antibodies against Porphyromonas gingivalis strains by immunization with recombinant gingipain domains
    FEMS Immunol Med Microbiol (2006) 47, 287-295. PubMed  Europe PubMed DOI
    64. 2005
  64. Beikler,T., Peters,U., Prior,K., Ehmke,B. and Flemmig,T.F.
    Sequence variations in rgpA and rgpB of Porphyromonas gingivalis in periodontitis
    J Periodontal Res (2005) 40, 193-198. PubMed  Europe PubMed DOI
  65. Rangarajan,M., Hashim,A., Aduse-Opoku,J., Paramonov,N., Hounsell,E.F. and Curtis,M.A.
    Expression of Arg-gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50
    Infect Immun (2005) 73, 4864-4878. PubMed  Europe PubMed DOI  PMC  EPMC
  66. Sato,K., Sakai,E., Veith,P.D., Shoji,M., Kikuchi,Y., Yukitake,H., Ohara,N., Naito,M., Okamoto,K., Reynolds,E.C. and Nakayama,K.
    Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis
    J Biol Chem (2005) 280, 8668-8677. PubMed  Europe PubMed DOI
  67. [YEAR:1-5-2005]Tancharoen,S., Sarker,K.P., Imamura,T., Biswas,K.K., Matsushita,K., Tatsuyama,S., Travis,J., Potempa,J., Torii,M. and Maruyama,I.
    Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling
    J Immunol (1-5-2005) 174, 5796-5804. PubMed  Europe PubMed
  68. Yun,P.L., Decarlo,A.A., Chapple,C.C. and Hunter,N.
    Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of Porphyromonas gingivalis for the pathology of periodontal disease
    Infect Immun (2005) 73, 1386-1398. PubMed  Europe PubMed DOI  PMC  EPMC
    69. 2004
  69. Goulet,V., Britigan,B., Nakayama,K. and Grenier,D.
    Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals
    Infect Immun (2004) 72, 4351-4356. PubMed  Europe PubMed DOI  PMC  EPMC
  70. Imamura,T., Potempa,J. and Travis,J.
    Gingipain R
    [ISSN:0-12-079610-4] (2004) 2, 1319-1328.  V
  71. Imamura,T., Potempa,J. and Travis,J.
    Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases
    Biol Chem (2004) 385, 989-996. PubMed  Europe PubMed DOI  V
  72. [YEAR:10-9-2004]Kadowaki,T., Baba,A., Abe,N., Takii,R., Hashimoto,M., Tsukuba,T., Okazaki,S., Suda,Y., Asao,T. and Yamamoto,K.
    Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors
    Mol Pharmacol (10-9-2004) 66, 1599-1606. PubMed  Europe PubMed DOI  I
  73. Liu,X., Sroka,A., Potempa,J. and Genco,C.A.
    Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR
    Biol Chem (2004) 385, 1049-1057. PubMed  Europe PubMed DOI
  74. Okamoto,M., Sugimoto,A., Leung,K.P., Nakayama,K., Kamaguchi,A. and Maeda,N.
    Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis
    Oral Microbiol Immunol (2004) 19, 118-120. PubMed  Europe PubMed DOI  I
  75. [YEAR:23-1-2004]Smalley,J.W., Thomas,M.F., Birss,A.J., Withnall,R. and Silver,J.
    A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
    Biochem J (23-1-2004) 379, 833-840. PubMed  Europe PubMed DOI  PMC  EPMC
  76. Vanterpool,E., Roy,F. and Fletcher,H.M.
    The vimE gene downstream of vimA is independently expressed and is involved in modulating proteolytic activity in Porphyromonas gingivalis W83
    Infect Immun (2004) 72, 5555-5564. PubMed  Europe PubMed DOI  PMC  EPMC
    77. 2003
  77. [YEAR:14-10-2003]Ally,N., Whisstock,J.C., Sieprawska-Lupa,M., Potempa,J., le Bonniec,B.F., Travis,J. and Pike,R.N.
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  91. Tada,H., Sugawara,S., Nemoto,E., Takahashi,N., Imamura,T., Potempa,J., Travis,J., Shimauchi,H. and Takada,H.
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    Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion
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