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Literature for peptidase C25.001: gingipain RgpA

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kamio,N., Cueno,M.E., Takagi,A. and Imai,K.<br>Porphyromonas gingivalis gingipain potentially activates influenza A virus infectivity through proteolytic cleavage of viral hemagglutinin<br>J Biol Chem (2025) , 108166-108166. PubMed  Europe PubMed DOI
    2. 2024
  2. Wei,W., Sun,J., Ji,Z., Hu,J. and Jiang,Q.<br>Gingipain and oncostatin M synergistically disrupt kidney tight junctions in periodontitis-associated acute kidney injury<br>J Periodontol (2024) 95, 867-879. PubMed  Europe PubMed DOI
    3. 2023
  3. Chen,H., Rosen,C.E., Gonzalez-Hernandez,J.A., Song,D., Potempa,J., Ring,A.M. and Palm,N.W.<br>Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions<br>Cell (2023) 186, 3095-3110. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Mahmud,A.S.M., Seers,C.A., Huq,N.L., Zhang,L., Butler,C.A., Moore,C., Cross,K.J. and Reynolds,E.C.<br>Production and properties of adhesin-free gingipain proteinase RgpA<br>Sci Rep (2023) 13, 10780-10780. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2022
  5. Castillo,D.M., Castillo,Y., Delgadillo,N.A., Neuta,Y., Lafaurie,G.I., Romero-Sanchez,C. and Castellanos,J.E.<br>Purification of RgpA from external outer membrane vesicles of Porphyromonas gingivalis<br>Anaerobe (2022) 77, 102647-102647. PubMed  Europe PubMed DOI
  6. Castillo,Y., Castellanos,J.E., Lafaurie,G.I. and Castillo,D.M.<br>Porphyromonas gingivalis outer membrane vesicles modulate cytokine and chemokine production by gingipain-dependent mechanisms in human macrophages<br>Arch Oral Biol (2022) 140, 105453-105453. PubMed  Europe PubMed DOI
  7. Chow,Y.C., Yam,H.C., Gunasekaran,B., Lai,W.Y., Wo,W.Y., Agarwal,T., Ong,Y.Y., Cheong,S.L. and Tan,S.A.<br>Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases<br>Front Cell Infect Microbiol (2022) 12, 987683-987683. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Ciaston,I., Budziaszek,J., Satala,D., Potempa,B., Fuchs,A., Rapala-Kozik,M., Mizgalska,D., Dobosz,E., Lamont,R.J., Potempa,J. and Koziel,J.<br>Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis<br>MBio (2022) 13, e0378721-e0378721. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Moore,C., Cheng,Y., Tjokro,N., Zhang,B., Kerr,M., Hayati,M., Chang,K.C.J., Shah,N., Chen,C. and Jokerst,J.V.<br>A Photoacoustic-Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis<br>Angew Chem Int Ed Engl (2022) 61, e202201843-e202201843. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Sabbagh,M.N. and Decourt,B.<br>COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease<br>Expert Opin Investig Drugs (2022) 31, 987-993. PubMed  Europe PubMed DOI  I
    11. 2021
  11. Movilla,S., Marti,S., Roca,M. and Moliner,V.<br>Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations<br>J Chem Inf Model (2021) PubMed  Europe PubMed DOI
    12. 2020
  12. Mo,W., Luo,H., Wu,J., Xu,N., Zhang,F., Qiu,Q., Zhu,W. and Liang,M.<br>Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin beta3 in RAW264.7 cells<br>J Mol Histol (2020) 51, 147-159. PubMed  Europe PubMed DOI
  13. Nakanishi,H., Nonaka,S. and Wu,Z.<br>Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer's disease<br>CNS Neurol Disord Drug Targets (2020) PubMed  Europe PubMed DOI
  14. Nonaka,S. and Nakanishi,H.<br>Secreted gingipains from Porphyromonas gingivalis induce microglia migration through endosomal signaling by protease-activated receptor 2<br>Neurochem Int (2020) 140, 104840-104840. PubMed  Europe PubMed DOI  K
  15. Nunes,J.M., Fillis,T., Page,M.J., Venter,C., Lancry,O., Kell,D.B., Windberger,U. and Pretorius,E.<br>Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics<br>Front Immunol (2020) 11, 1551-1551. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Seers,C.A., Mahmud,A.S.M., Huq,N.L., Cross,K.J. and Reynolds,E.C.<br>Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains<br>J Oral Microbiol (2020) 13, 1858001-1858001. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2018
  17. Alhogail,S., Suaifan,G.A.R.Y., Bizzarro,S., Kaman,W.E., Bikker,F.J., Weber,K., Cialla-May,D., Popp,J. and Zourob,M.<br>On site visual detection of Porphyromonas gingivalis related periodontitis by using a magnetic-nanobead based assay for gingipains protease biomarkers<br>Mikrochim Acta (2018) 185, 149-149. PubMed  Europe PubMed DOI  A
    18. 2017
  18. Kariu,T., Nakao,R., Ikeda,T., Nakashima,K., Potempa,J. and Imamura,T.<br>Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids<br>J Periodontal Res (2017) 52, 89-96. PubMed  Europe PubMed DOI  I
    19. 2016
  19. O'Brien-Simpson,N.M., Holden,J.A., Lenzo,J.C., Tan,Y., Brammar,G.C., Walsh,K.A., Singleton,W., Orth,R.K.H., Slakeski,N., Cross,K.J., Darby,I.B., Becher,D., Rowe,T., Morelli,A.B., Hammet,A., Nash,A., Brown,A., Ma,B., Vingadassalom,D., McCluskey,J., Kleanthous,H. and Reynolds,E.C.<br>A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis<br>NPJ Vaccines (2016) 1, 16022-16022. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Plaza,K., Kalinska,M., Bochenska,O., Meyer-Hoffert,U., Wu,Z., Fischer,J., Falkowski,K., Sasiadek,L., Bielecka,E., Potempa,B., Kozik,A., Potempa,J. and Kantyka,T.<br>Gingipains of Porphyromonas gingivalis affect the stability and function of serine protease inhibitor of Kazal-type 6 (SPINK6), a tissue inhibitor of human kallikreins<br>J Biol Chem (2016) 291, 18753-18764. PubMed  Europe PubMed DOI
    21. 2015
  21. Jung,Y.J., Jun,H.K. and Choi,B.K.<br>Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation<br>Cell Microbiol (2015) 17, 1304-1319. PubMed  Europe PubMed DOI
  22. Palm,E., Khalaf,H. and Bengtsson,T.<br>Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis<br>Mol Oral Microbiol (2015) 30, 74-85. PubMed  Europe PubMed DOI
    23. 2014
  23. Haraguchi,A., Miura,M., Fujise,O., Hamachi,T. and Nishimura,F.<br>Porphyromonas gingivalis gingipain is involved in the detachment and aggregation of Aggregatibacter actinomycetemcomitans biofilm<br>Mol Oral Microbiol (2014) 29, 131-143. PubMed  Europe PubMed DOI  I
  24. Kataoka,S., Baba,A., Suda,Y., Takii,R., Hashimoto,M., Kawakubo,T., Asao,T., Kadowaki,T. and Yamamoto,K.<br>A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy<br>FASEB J (2014) 28, 3564-3578. PubMed  Europe PubMed DOI  I
  25. Taniguchi,M., Matsuhashi,Y., Abe,T.K., Ishiyama,Y., Saitoh,E., Kato,T., Ochiai,A. and Tanaka,T.<br>Contribution of cationic amino acids toward the inhibition of Arg-specific cysteine proteinase (Arg-gingipain) by the antimicrobial dodecapeptide, CL(14-25), from rice protein<br>Biopolymers (2014) 102, 379-389. PubMed  Europe PubMed DOI  I
    26. 2013
  26. Huq,N.L., Seers,C.A., Toh,E.C., Dashper,S.G., Slakeski,N., Zhang,L., Ward,B.R., Meuric,V., Chen,D., Cross,K.J. and Reynolds,E.C.<br>Propeptide-mediated inhibition of cognate gingipain proteinases<br>PLoS ONE (2013) 8, e65447-e65447. PubMed  Europe PubMed DOI  PMC  EPMC
  27. van der Post,S., Subramani,D.B., Backstrom,M., Johansson,M.E., Vester-Christensen,M.B., Mandel,U., Bennett,E.P., Clausen,H., Dahlen,G., Sroka,A., Potempa,J. and Hansson,G.C.<br>Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB)<br>J Biol Chem (2013) 288, 14636-14646. PubMed  Europe PubMed DOI  P
  28. Veillard,F., Sztukowska,M., Mizgalska,D., Ksiazek,M., Houston,J., Potempa,B., Enghild,J.J., Thogersen,I.B., Gomis-Ruth,F.X., Nguyen,K.A. and Potempa,J.<br>Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases<br>Biochim Biophys Acta Gen Subj (2013) 1830, 4218-4228. PubMed  Europe PubMed DOI
  29. Zhou,X.Y., Gao,J.L., Hunter,N., Potempa,J. and Nguyen,K.A.<br>Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis<br>Mol Microbiol (2013) 89, 903-917. PubMed  Europe PubMed DOI
    30. 2012
  30. Kaman,W.E., Galassi,F., de Soet,J.J., Bizzarro,S., Loos,B.G., Veerman,E.C., van Belkum,A., Hays,J.P. and Bikker,F.J.<br>Highly specific protease-based approach for detection of Porphyromonas gingivalis in diagnosis of periodontitis<br>J Clin Microbiol (2012) 50, 104-112. PubMed  Europe PubMed DOI
  31. Nguyen,K.A. and Potempa,J.<br>Gingipain R<br>[ISSN:978-0-12-407743-0] (2012) 3, 2328-2336. DOI
  32. Sztukowska,M., Veillard,F., Potempa,B., Bogyo,M., Enghild,J.J., Thogersen,I.B., Nguyen,K.A. and Potempa,J.<br>Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes<br>Biol Chem (2012) 393, 971-977. PubMed  Europe PubMed DOI
  33. Veillard,F., Potempa,B., Poreba,M., Drag,M. and Potempa,J.<br>Gingipain aminopeptidase activities in Porphyromonas gingivalis<br>Biol Chem (2012) 393, 1471-1476. PubMed  Europe PubMed DOI
    34. 2011
  34. Skottrup,P.D., Leonard,P., Kaczmarek,J.Z., Veillard,F., Enghild,J.J., O'Kennedy,R., Sroka,A., Clausen,R.P., Potempa,J. and Riise,E.<br>Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis<br>Anal Biochem (2011) 415, 158-167. PubMed  Europe PubMed DOI
  35. Slakeski,N., Seers,C.A., Ng,K., Moore,C., Cleal,S.M., Veith,P.D., Lo,A.W. and Reynolds,E.C.<br>C-terminal domain residues important for secretion and attachment of RgpB in Porphyromonas gingivalis<br>J Bacteriol (2011) 193, 132-142. PubMed  Europe PubMed DOI
  36. Smalley,J.W., Byrne,D.P., Birss,A.J., Wojtowicz,H., Sroka,A., Potempa,J. and Olczak,T.<br>HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis<br>PLoS ONE (2011) 6, e17182-e17182. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Toh,E.C., Dashper,S.G., Huq,N.L., Attard,T.J., O'Brien-Simpson,N.M., Chen,Y.Y., Cross,K.J., Stanton,D.P., Paolini,R.A. and Reynolds,E.C.<br>Porphyromonas gingivalis cysteine proteinase inhibition by kappa-casein peptides<br>Antimicrob Agents Chemother (2011) 55, 1155-1161. PubMed  Europe PubMed DOI
    38. 2010
  38. Guo,Y., Nguyen,K.A. and Potempa,J.<br>Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins<br>Periodontol 2000 (2010) 54, 15-44. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Kim,D. and Lee,D.S.<br>A computational simulation study of benzamidine derivatives binding to arginine-specific gingipain (HRgpA) from periodontopathogen Porphyromonas gingivalis<br>Int J Mol Sci (2010) 11, 3252-3265. PubMed  Europe PubMed DOI  PMC  EPMC  I
  40. Li,N., Yun,P., Nadkarni,M.A., Ghadikolaee,N.B., Nguyen,K.A., Lee,M., Hunter,N. and Collyer,C.A.<br>Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis<br>Mol Microbiol (2010) 76, 861-873. PubMed  Europe PubMed DOI
  41. Saiki,K. and Konishi,K.<br>Identification of a novel Porphyromonas gingivalis outer membrane protein, PG534, required for the production of active gingipains<br>FEMS Microbiol Lett (2010) 310, 168-174. PubMed  Europe PubMed DOI
    42. 2009
  42. Fitzpatrick,R.E., Wijeyewickrema,L.C. and Pike,R.N.<br>The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis<br>Future Microbiol (2009) 4, 471-487. PubMed  Europe PubMed DOI
  43. Inomata,M., Ishihara,Y., Matsuyama,T., Imamura,T., Maruyama,I., Noguchi,T. and Matsushita,K.<br>Degradation of vascular endothelial thrombomodulin by arginine-and lysine-specific cysteine proteases from Porphyromonas gingivalis<br>J Periodontol (2009) 80, 1511-1517. PubMed  Europe PubMed DOI
  44. Ishiguro,I., Saiki,K. and Konishi,K.<br>PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system<br>FEMS Microbiol Lett (2009) 292, 261-267. PubMed  Europe PubMed DOI
  45. Kantyka,T., Latendorf,T., Wiedow,O., Bartels,J., Glaser,R., Dubin,G., Schroder,J.M., Potempa,J. and Meyer-Hoffert,U.<br>Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage<br>Biol Chem (2009) 390, 1313-1320. PubMed  Europe PubMed DOI  P
  46. Tam,V., O'Brien-Simpson,N.M., Chen,Y.Y., Sanderson,C.J., Kinnear,B. and Reynolds,E.C.<br>The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis inactivate the Th2 cytokines interleukin-4 and interleukin-5<br>Infect Immun (2009) 77, 1451-1458. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2008
  47. Bania,J., Kubiak,A., Wojtachnio,K. and Polanowski,A.<br>Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis<br>J Periodontal Res (2008) 43, 232-236. PubMed  Europe PubMed DOI
  48. Dias,I.H., Marshall,L., Lambert,P.A., Chapple,I.L., Matthews,J.B. and Griffiths,H.R.<br>Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant<br>Infect Immun (2008) 76, 317-323. PubMed  Europe PubMed DOI  PMC  EPMC
  49. Sheets,S.M., Robles-Price,A.G., McKenzie,R.M., Casiano,C.A. and Fletcher,H.M.<br>Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis<br>Front Biosci (2008) 13, 3215-3238. PubMed  Europe PubMed DOI  V
  50. Slaney,J.M. and Curtis,M.A.<br>Mechanisms of evasion of complement by Porphyromonas gingivalis<br>Front Biosci (2008) 13, 188-196. PubMed  Europe PubMed DOI
    51. 2007
  51. Inomata,M., Into,T., Ishihara,Y., Nakashima,M., Noguchi,T. and Matsushita,K.<br>Arginine-specific gingipain A from Porphyromonas gingivalis induces Weibel-Palade body exocytosis and enhanced activation of vascular endothelial cells through protease-activated receptors<br>Microbes Infect (2007) 9, 1500-1506. PubMed  Europe PubMed DOI
  52. Kadowaki,T., Takii,R., Yamatake,K., Kawakubo,T., Tsukuba,T. and Yamamoto,K.<br>A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells<br>Front Biosci (2007) 12, 4800-4809. PubMed  Europe PubMed DOI
  53. Kato,T., Tsuda,T., Omori,H., Kato,T., Yoshimori,T. and Amano,A.<br>Maturation of fimbria precursor protein by exogenous gingipains in Porphyromonas gingivalis gingipain-null mutant<br>FEMS Microbiol Lett (2007) 273, 96-102. PubMed  Europe PubMed DOI
  54. Nguyen,K.A., Travis,J. and Potempa,J.<br>Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-negative bacteria?<br>J Bacteriol (2007) 189, 833-843. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Page,R.C., Lantz,M.S., Darveau,R., Jeffcoat,M., Mancl,L., Houston,L., Braham,P. and Persson,G.R.<br>Immunization of Macaca fascicularis against experimental periodontitis using a vaccine containing cysteine proteases purified from Porphyromonas gingivalis<br>Oral Microbiol Immunol (2007) 22, 162-168. PubMed  Europe PubMed DOI
  56. Pathirana,R.D., O'Brien-Simpson,N.M., Brammar,G.C., Slakeski,N. and Reynolds,E.C.<br>Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model<br>Infect Immun (2007) 75, 1436-1442. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Popadiak,K., Potempa,J., Riesbeck,K. and Blom,A.M.<br>Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system<br>J Immunol (2007) 178, 7242-7250. PubMed  Europe PubMed
  58. Smalley,J.W., Birss,A.J., Szmigielski,B. and Potempa,J.<br>Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin<br>Arch Biochem Biophys (2007) 465, 44-49. PubMed  Europe PubMed DOI  I
    59. 2006
  59. [YEAR:9-3-2006]Bialas,A., Grembecka,J., Krowarsch,D., Otlewski,J., Potempa,J. and Mucha,A.<br>Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity<br>J Med Chem (9-3-2006) 49, 1744-1753. PubMed  Europe PubMed DOI  I
  60. Cronan,C.A., Potempa,J., Travis,J. and Mayo,J.A.<br>Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II)<br>Oral Microbiol Immunol (2006) 21, 212-217. PubMed  Europe PubMed DOI  I
  61. Matsushita,K., Imamura,T., Tancharoen,S., Tatsuyama,S., Tomikawa,M., Travis,J., Potempa,J., Torii,M. and Maruyama,I.<br>Selective inhibition of Porphyromonas gingivalis growth by a factor Xa inhibitor, DX-9065a<br>J Periodontal Res (2006) 41, 171-176. PubMed  Europe PubMed DOI  I
  62. Slaney,J.M., Gallagher,A., Aduse-Opoku,J., Pell,K. and Curtis,M.A.<br>Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement<br>Infect Immun (2006) 74, 5352-5361. PubMed  Europe PubMed DOI  K
  63. Yasaki-Inagaki,Y., Inagaki,S., Yamada,S., Okuda,K. and Ishihara,K.<br>Production of protective antibodies against Porphyromonas gingivalis strains by immunization with recombinant gingipain domains<br>FEMS Immunol Med Microbiol (2006) 47, 287-295. PubMed  Europe PubMed DOI
    64. 2005
  64. Beikler,T., Peters,U., Prior,K., Ehmke,B. and Flemmig,T.F.<br>Sequence variations in rgpA and rgpB of Porphyromonas gingivalis in periodontitis<br>J Periodontal Res (2005) 40, 193-198. PubMed  Europe PubMed DOI
  65. Rangarajan,M., Hashim,A., Aduse-Opoku,J., Paramonov,N., Hounsell,E.F. and Curtis,M.A.<br>Expression of Arg-gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50<br>Infect Immun (2005) 73, 4864-4878. PubMed  Europe PubMed DOI  PMC  EPMC
  66. Sato,K., Sakai,E., Veith,P.D., Shoji,M., Kikuchi,Y., Yukitake,H., Ohara,N., Naito,M., Okamoto,K., Reynolds,E.C. and Nakayama,K.<br>Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis<br>J Biol Chem (2005) 280, 8668-8677. PubMed  Europe PubMed DOI
  67. [YEAR:1-5-2005]Tancharoen,S., Sarker,K.P., Imamura,T., Biswas,K.K., Matsushita,K., Tatsuyama,S., Travis,J., Potempa,J., Torii,M. and Maruyama,I.<br>Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling<br>J Immunol (1-5-2005) 174, 5796-5804. PubMed  Europe PubMed
  68. Yun,P.L., Decarlo,A.A., Chapple,C.C. and Hunter,N.<br>Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of Porphyromonas gingivalis for the pathology of periodontal disease<br>Infect Immun (2005) 73, 1386-1398. PubMed  Europe PubMed DOI  PMC  EPMC
    69. 2004
  69. Goulet,V., Britigan,B., Nakayama,K. and Grenier,D.<br>Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals<br>Infect Immun (2004) 72, 4351-4356. PubMed  Europe PubMed DOI  PMC  EPMC
  70. Imamura,T., Potempa,J. and Travis,J.<br>Gingipain R<br>[ISSN:0-12-079610-4] (2004) 2, 1319-1328.  V
  71. Imamura,T., Potempa,J. and Travis,J.<br>Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases<br>Biol Chem (2004) 385, 989-996. PubMed  Europe PubMed DOI  V
  72. [YEAR:10-9-2004]Kadowaki,T., Baba,A., Abe,N., Takii,R., Hashimoto,M., Tsukuba,T., Okazaki,S., Suda,Y., Asao,T. and Yamamoto,K.<br>Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors<br>Mol Pharmacol (10-9-2004) 66, 1599-1606. PubMed  Europe PubMed DOI  I
  73. Liu,X., Sroka,A., Potempa,J. and Genco,C.A.<br>Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR<br>Biol Chem (2004) 385, 1049-1057. PubMed  Europe PubMed DOI
  74. Okamoto,M., Sugimoto,A., Leung,K.P., Nakayama,K., Kamaguchi,A. and Maeda,N.<br>Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis<br>Oral Microbiol Immunol (2004) 19, 118-120. PubMed  Europe PubMed DOI  I
  75. [YEAR:23-1-2004]Smalley,J.W., Thomas,M.F., Birss,A.J., Withnall,R. and Silver,J.<br>A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin<br>Biochem J (23-1-2004) 379, 833-840. PubMed  Europe PubMed DOI  PMC  EPMC
  76. Vanterpool,E., Roy,F. and Fletcher,H.M.<br>The vimE gene downstream of vimA is independently expressed and is involved in modulating proteolytic activity in Porphyromonas gingivalis W83<br>Infect Immun (2004) 72, 5555-5564. PubMed  Europe PubMed DOI  PMC  EPMC
    77. 2003
  77. [YEAR:14-10-2003]Ally,N., Whisstock,J.C., Sieprawska-Lupa,M., Potempa,J., le Bonniec,B.F., Travis,J. and Pike,R.N.<br>Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes<br>Biochemistry (14-10-2003) 42, 11693-11700. PubMed  Europe PubMed DOI
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  87. Katz,J., Yang,Q.B., Zhang,P., Potempa,J., Travis,J., Michalek,S.M. and Balkovetz,D.F.<br>Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains<br>Infect Immun (2002) 70, 2512-2518. PubMed  Europe PubMed DOI  PMC  EPMC
  88. Krauser,J.A., Potempa,J., Travis,J. and Powers,J.C.<br>Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency<br>Biol Chem (2002) 383, 1193-1198. PubMed  Europe PubMed DOI  I
  89. Oleksy,A., Banbula,A., Bugno,M., Travis,J. and Potempa,J.<br>Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation<br>Microb Pathog (2002) 32, 173-181. PubMed  Europe PubMed DOI
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  91. Tada,H., Sugawara,S., Nemoto,E., Takahashi,N., Imamura,T., Potempa,J., Travis,J., Shimauchi,H. and Takada,H.<br>Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production<br>Infect Immun (2002) 70, 3304-3307. PubMed  Europe PubMed DOI  PMC  EPMC
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  92. Baba,A., Abe,N., Kadowaki,T., Nakanishi,H., Ohishi,M., Asao,T. and Yamamoto,K.<br>Arg-gingipain is responsible for the degradation of cell adhesion molecules of human gingival fibroblasts and their death induced by Porphyromonas gingivalis<br>Biol Chem (2001) 382, 817-824. PubMed  Europe PubMed DOI
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