$VAR1 = undef;

Summary for peptidase C12.003: ubiquitinyl hydrolase-L3

Names
MEROPS Name	ubiquitinyl hydrolase-L3
Other names	ubiquitin C-terminal hydrolase UCH-L3 (mammal), UCHL3

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C12 >> Subfamily (none) >> C12.003
Holotype	ubiquitinyl hydrolase-L3 (Homo sapiens), Uniprot accession P15374 (peptidase unit: 4-230), MERNUM MER0000836
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00095
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase 3.4.19.12
Enzymology	BRENDA database
Activity status	human: active (Wilkinson, 2004) mouse: active (by similarity to human) (Dang et al., 1998)
Physiology	Recycling of ubiquitin in ubiquitin-dependent proteolysis.
Knockout	Mice with a targeted mutation in ubiquitinyl hydrolase L3 were normal (Kurihara et al., 2000), but loss of ubiquitinyl hydrolase L3 together with ubiquitinyl hydrolase L1 (C12.001) led to neurodegeneration, posterior paralysis and dysphagia (Kurihara et al., 2001).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/UCHL3
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	L/R/G/Gkim/-/-/- (based on 26 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	23	26	0	0	0	0
Pro	0	0	0	0	0	0	0	2
Ala	0	0	1	0	0	0	0	0
Val	1	0	1	0	0	0	0	0
Leu	19	0	0	0	0	0	0	0
Ile	0	0	0	0	2	2	2	0
Met	0	0	0	0	2	0	0	0
Phe	1	0	0	0	0	0	0	2
Tyr	1	1	0	0	0	0	0	0
Trp	1	1	0	0	0	0	0	0
Ser	0	0	0	0	0	0	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	0	2	0	0
Asp	0	0	0	0	1	0	0	0
Glu	0	0	0	0	0	0	2	0
Lys	1	1	0	0	5	0	0	0
Arg	1	23	0	0	0	0	0	0
His	0	0	0	0	1	0	0	0