Substrates for peptidase C12.003: ubiquitinyl hydrolase-L3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ac-Arg-Arg-Gly-Gly-AFC			Ac-Arg-Arg-Gly-Gly+AFC	S	Arg	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Leu-Arg-Ala-Gly-AFC			Ac-Leu-Arg-Ala-Gly+AFC	S	Leu	Arg	Ala	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Leu-Arg-Gly-Gly-AFC			Ac-Leu-Arg-Gly-Gly+AFC	S	Leu	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Leu-Arg-Nle-Gly-AFC			Ac-Leu-Arg-Nle-Gly+AFC	S	Leu	Arg	Nle	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Leu-Arg-Val-Gly-AFC			Ac-Leu-Arg-Val-Gly+AFC	S	Leu	Arg	Val	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Leu-Lys-Gly-Gly-AFC			Ac-Leu-Lys-Gly-Gly+AFC	S	Leu	Lys	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Leu-Trp-Gly-Gly-AFC			Ac-Leu-Trp-Gly-Gly+AFC	S	Leu	Trp	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Leu-Tyr-Gly-Gly-AFC			Ac-Leu-Tyr-Gly-Gly+AFC	S	Leu	Tyr	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Lys-Arg-Gly-Gly-AFC			Ac-Lys-Arg-Gly-Gly+AFC	S	Lys	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Nle-Arg-Gly-Gly-AFC			Ac-Nle-Arg-Gly-Gly+AFC	S	Nle	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Phe-Arg-Gly-Gly-AFC			Ac-Phe-Arg-Gly-Gly+AFC	S	Phe	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Trp-Arg-Gly-Gly-AFC			Ac-Trp-Arg-Gly-Gly+AFC	S	Trp	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Tyr-Arg-Gly-Gly-AFC			Ac-Tyr-Arg-Gly-Gly+AFC	S	Tyr	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Ac-Val-Arg-Gly-Gly-AFC			Ac-Val-Arg-Gly-Gly+AFC	S	Val	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
alpha-ubiquitin-Lys	P0CG47	1-76	Peptide-Gly76+Lys	S	Leu	Arg	Gly	Gly	Lys	-	-	-	Larsen et al., 1998
diubiquitin-ac-Lys	P0CG47	1-76	Peptide-Gly76+Lys	S	Leu	Arg	Gly	Gly	Lys	-	-	-	Larsen et al., 1998
diubiquitin-Lys	P0CG47	1-76	Peptide-Gly76+Lys	S	Leu	Arg	Gly	Gly	Lys	-	-	-	Larsen et al., 1998
epsilon-ubiquitin-ac-Lys	P0CG47	1-76	Peptide-Gly76+Lys	S	Leu	Arg	Gly	Gly	Lys	-	-	-	Larsen et al., 1998
epsilon-ubiquitin-Lys	P0CG47	1-76	Peptide-Gly76+Lys	S	Leu	Arg	Gly	Gly	Lys	-	-	-	Larsen et al., 1998
ubiquitin-Asp	P0CG47	1-76	Peptide-Gly76+Asp	S	Leu	Arg	Gly	Gly	Asp	-	-	-	Larsen et al., 1998
ubiquitin-CEP52	P0CG47	1-76	Peptide-Gly76+Ile1-peptide	S	Leu	Arg	Gly	Gly	Ile	Ile	Glu	Pro	Larsen et al., 1998
ubiquitin-His	P0CG47	1-76	Peptide-Gly76+His	S	Leu	Arg	Gly	Gly	His	-	-	-	Larsen et al., 1998
ubiquitin-IIEPSLRQLA	P0CG47	1-76	Peptide-Gly76+Ile-peptide	S	Leu	Arg	Gly	Gly	Ile	Ile	Glu	Pro	Larsen et al., 1998
ubiquitin-MQIFVKTLTG	P0CG47	1-76	Peptide-Gly76+Met-peptide	S	Leu	Arg	Gly	Gly	Met	Gln	Ile	Phe	Larsen et al., 1998
ubiquitin-MQIFVRPR	P0CG47	1-76	Peptide-Gly76+Met-peptide	S	Leu	Arg	Gly	Gly	Met	Gln	Ile	Phe	Larsen et al., 1998
ubiquitin-OEt	P0CG47	1-76	Peptide-Gly76+OEt	S	Leu	Arg	Gly	Gly	OEt	-	-	-	Larsen et al., 1998