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Literature for peptidase C12.003: ubiquitinyl hydrolase-L3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kim,M.S. and Kim,M.S.
    Deubiquitination of epidermal growth factor receptor by ubiquitin-specific peptidase 54 enhances drug sensitivity to gefitinib in gefitinib-resistant non-small cell lung cancer cells
    PLoS ONE20, e0320668-e0320668. PubMed  Europe PubMed DOI
    2. 2024
  2. Fan,L., You,H., Jiang,X., Niu,Y., Chen,Z., Wang,H., Xu,Y., Zhou,P., Wei,L., Jiang,T., Deng,D., Xue,L., Peng,Y., Xing,W. and Shao,N.
    UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells
    Cell Mol Life Sci81, 247-247. PubMed  Europe PubMed DOI
  3. Lei,H., Xu,H. and Wu,Y.
    Role of UCHL3 in health and disease
    Biochem Biophys Res Commun734, 150626-150626. PubMed  Europe PubMed DOI  V
  4. Xu,Z., Zhang,N. and Shi,L.
    Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them
    Am J Cancer Res14, 2666-2694. PubMed  Europe PubMed DOI  V
    5. 2023
  5. Liu,T., Fan,M.Q., Xie,X.X., Shu,Q.P., Du,X.H., Qi,L.Z., Zhang,X.D., Zhang,M.H., Shan,G., Du,R.L. and Li,S.Z.
    Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression
    J Transl Med21, 656-656. PubMed  Europe PubMed DOI
    6. 2022
  6. Hafez,N., Modather El-Awadly,Z. and Arafa,R.K.
    UCH-L3 structure and function: Insights about a promising drug target
    Eur J Med Chem227, 113970-113970. PubMed  Europe PubMed DOI
    7. 2020
  7. Gui,W., Shen,S. and Zhuang,Z.
    Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes
    J Am Chem Soc142, 19493-19501. PubMed  Europe PubMed DOI
  8. Hewitt,C.S., Krabill,A.D., Das,C. and Flaherty,D.P.
    Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases
    Biochemistry59, 3447-3462. PubMed  Europe PubMed DOI
  9. Li,J., Zheng,Y., Li,X., Dong,X., Chen,W., Guan,Z. and Zhang,C.
    UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT/mTOR signaling pathway
    Am J Transl Res12, 6445-6454. PubMed  Europe PubMed  K
  10. Ouyang,L., Yan,B., Liu,Y., Mao,C., Wang,M., Liu,N., Wang,Z., Liu,S., Shi,Y., Chen,L., Wang,X., Cheng,Y., Cao,Y., Xiao,D., Zhang,L., Liu,S. and Tao,Y.
    The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor
    Signal Transduct Target Ther5, 78-78. PubMed  Europe PubMed DOI
    11. 2019
  11. Song,Z., Li,J., Zhang,L., Deng,J., Fang,Z., Xiang,X. and Xiong,J.
    UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization
    Am J Cancer Res9, 1970-1981. PubMed  Europe PubMed
  12. Song,Z., Tu,X., Zhou,Q., Huang,J., Chen,Y., Liu,J., Lee,S., Kim,W., Nowsheen,S., Luo,K., Yuan,J. and Lou,Z.
    A novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair
    Cell Death Dis10, 398-398. PubMed  Europe PubMed DOI  I
    13. 2018
  13. Nishi,R., Wijnhoven,P.W.G., Kimura,Y., Matsui,M., Konietzny,R., Wu,Q., Nakamura,K., Blundell,T.L. and Kessler,B.M.
    The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage
    Sci Rep8, 17891-17891. PubMed  Europe PubMed DOI
    14. 2015
  14. Bett,J.S., Ritorto,M.S., Ewan,R., Jaffray,E.G., Virdee,S., Chin,J.W., Knebel,A., Kurz,T., Trost,M., Tatham,M.H. and Hay,R.T.
    Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers
    Biochem J466, 489-498. PubMed  Europe PubMed DOI
    15. 2014
  15. Navarro,M.F., Carmody,L., Romo-Fewell,O., Lokensgard,M.E. and Love,J.J.
    Characterizing substrate selectivity of ubiquitin C-terminal hydrolase-L3 using engineered alpha-linked ubiquitin substrates
    Biochemistry53, 8031-8042. PubMed  Europe PubMed DOI  P
    16. 2012
  16. Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R.
    Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
    Chembiochem13, 1416-1420. PubMed  Europe PubMed DOI  P
  17. Issaenko,O.A. and Amerik,A.Y.
    Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes
    Cell Cycle11, 1804-1817. PubMed  Europe PubMed DOI  I
  18. Mtango,N.R., Sutovsky,M., Susor,A., Zhong,Z., Latham,K.E. and Sutovsky,P.
    Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development
    J Cell Physiol227, 1592-1603. PubMed  Europe PubMed DOI
  19. Zhou,Z.R., Zhang,Y.H., Liu,S., Song,A.X. and Hu,H.Y.
    Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains
    Biochem J441, 143-149. PubMed  Europe PubMed DOI
    20. 2011
  20. Dennissen,F.J., Kholod,N., Hermes,D.J., Kemmerling,N., Steinbusch,H.W., Dantuma,N.P. and van Leeuwen,F.W.
    Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)
    FEBS Lett585, 2568-2574. PubMed  Europe PubMed DOI
  21. Kim,J.Y., Lee,J.M. and Cho,J.Y.
    Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation
    FEBS Lett585, 1121-1126. PubMed  Europe PubMed DOI
    22. 2010
  22. Setsuie,R., Suzuki,M., Tsuchiya,Y. and Wada,K.
    Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses
    Neurochem Int56, 911-918. PubMed  Europe PubMed DOI  K
    23. 2009
  23. Andersson,F.I., Pina,D.G., Mallam,A.L., Blaser,G. and Jackson,S.E.
    Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3
    FEBS J276, 2625-2635. PubMed  Europe PubMed DOI
  24. Popp,M.W., Artavanis-Tsakonas,K. and Ploegh,H.L.
    Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations
    J Biol Chem284, 3593-3602. PubMed  Europe PubMed DOI
  25. Setsuie,R., Suzuki,M., Kabuta,T., Fujita,H., Miura,S., Ichihara,N., Yamada,D., Wang,Y.L., Ezaki,O., Suzuki,Y. and Wada,K.
    Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle
    FASEB J23, 4148-4157. PubMed  Europe PubMed DOI  K
  26. Setsuie,R., Sakurai,M., Sakaguchi,Y. and Wada,K.
    Ubiquitin dimers control the hydrolase activity of UCH-L3
    Neurochem Int54, 314-321. PubMed  Europe PubMed DOI
  27. Suzuki,M., Setsuie,R. and Wada,K.
    Ubiquitin carboxyl-terminal hydrolase L3 promotes insulin signaling and adipogenesis
    Endocrinology150, 5230-5239. PubMed  Europe PubMed DOI  K
    28. 2008
  28. Drag,M., Mikolajczyk,J., Bekes,M., Reyes-Turcu,F.E., Ellman,J.A., Wilkinson,K.D. and Salvesen,G.S.
    Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
    Biochem J415, 367-375. PubMed  Europe PubMed DOI  P
    29. 2007
  29. Butterworth,M.B., Edinger,R.S., Ovaa,H., Burg,D., Johnson,J.P. and Frizzell,R.A.
    The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
    J Biol Chem282, 37885-37893. PubMed  Europe PubMed DOI
  30. Hassiepen,U., Eidhoff,U., Meder,G., Bulber,J.F., Hein,A., Bodendorf,U., Lorthiois,E. and Martoglio,B.
    A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate
    Anal Biochem371, 201-207. PubMed  Europe PubMed DOI  A
  31. Hirayama,K., Aoki,S., Nishikawa,K., Matsumoto,T. and Wada,K.
    Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening
    Bioorg Med Chem15, 6810-6818. PubMed  Europe PubMed DOI  I
  32. Kwon,J.
    The new function of two ubiquitin C-terminal hydrolase isozymes as reciprocal modulators of germ cell apoptosis
    Exp Anim56, 71-77. PubMed  Europe PubMed DOI  K
    33. 2006
  33. Kwon,J., Sekiguchi,S., Wang,Y.L., Setsuie,R., Yoshikawa,Y. and Wada,K.
    The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis
    Exp Anim55, 35-43. PubMed  Europe PubMed DOI  K
    34. 2005
  34. [YEAR:5-11-2005]Misaghi,S., Galardy,P.J., Meester,W.J., Ovaa,H., Ploegh,H.L. and Gaudet,R.
    Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate
    J Biol Chem280, 1512-1520. PubMed  Europe PubMed DOI  S  I
  35. Tirat,A., Schilb,A., Riou,V., Leder,L., Gerhartz,B., Zimmermann,J., Worpenberg,S., Eidhoff,U., Freuler,F., Stettler,T., Mayr,L., Ottl,J., Leuenberger,B. and Filipuzzi,I.
    Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2
    Anal Biochem343, 244-255. PubMed  Europe PubMed DOI  A
  36. [YEAR:9-5-2005]Wood,M.A., Kaplan,M.P., Brensinger,C.M., Guo,W. and Abel,T.
    Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
    Hippocampus15, 610-621. PubMed  Europe PubMed DOI
    37. 2004
  37. Hemelaar,J., Borodovsky,A., Kessler,B.M., Reverter,D., Cook,J., Kolli,N., Gan-Erdene,T., Wilkinson,K.D., Gill,G., Lima,C.D., Ploegh,H.L. and Ovaa,H.
    Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins
    Mol Cell Biol24, 84-95. PubMed  Europe PubMed DOI  I
  38. Kwon,J., Wang,Y.L., Setsuie,R., Sekiguchi,S., Sato,Y., Sakurai,M., Noda,M., Aoki,S., Yoshikawa,Y. and Wada,K.
    Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
    Am J Pathol165, 1367-1374. PubMed  Europe PubMed DOI
  39. [YEAR:14-4-2004]Kwon,J., Wang,Y.L., Setsuie,R., Sekiguchi,S., Sakurai,M., Sato,Y., Lee,W.W., Ishii,Y., Kyuwa,S., Noda,M., Wada,K. and Yoshikawa,Y.
    Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice
    Biol Reprod71, 515-521. PubMed  Europe PubMed DOI
  40. [YEAR:1-6-2004]Mason,D.E., Ek,J., Peters,E.C. and Harris,J.L.
    Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry
    Biochemistry43, 6535-6544. PubMed  Europe PubMed DOI
  41. Wilkinson,K.D.
    Ubiquitin C-terminal hydrolase
    [ISSN:0-12-079610-4]2, 1225-1229.  V
    42. 2003
  42. Nam,M.J., Madoz-Gurpide,J., Wang,H., Lescure,P., Schmalbach,C.E., Zhao,R., Misek,D.E., Kuick,R., Brenner,D.E. and Hanash,S.M.
    Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3
    Proteomics3, 2108-2115. PubMed  Europe PubMed DOI
    43. 2001
  43. [YEAR:1-9-2001]Kurihara,L.J., Kikuchi,T., Wada,K. and Tilghman,S.M.
    Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia
    Hum Mol Genet10, 1963-1970. PubMed  Europe PubMed  K
    44. 2000
  44. Kurihara,L.J., Semenova,E., Levorse,J.M. and Tilghman,S.M.
    Expression and functional analysis of Uch-L3 during mouse development
    Mol Cell Biol20, 2498-2504. PubMed  Europe PubMed DOI
    45. 1999
  45. [YEAR:3-9-1999]Wilkinson,K.D., Laleli-Sahin,E., Urbauer,J., Larsen,C.N., Shih,G.H., Haas,A.L., Walsh,S.T. and Wand,A.J.
    The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3
    J Mol Biol291, 1067-1077. PubMed  Europe PubMed DOI
    46. 1998
  46. [YEAR:17-2-1998]Dang,L.C., Melandri,F.D. and Stein,R.L.
    Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes
    Biochemistry37, 1868-1879. PubMed  Europe PubMed DOI  A  I
  47. [YEAR:10-3-1998]Larsen,C.N., Krantz,B.A. and Wilkinson,K.D.
    Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases
    Biochemistry37, 3358-3368. PubMed  Europe PubMed DOI
  48. [YEAR:29-10-1998]Wada,H., Kito,K., Caskey,L.S., Yeh,E.T. and Kamitani,T.
    Cleavage of the C-terminus of NEDD8 by UCH-L3
    Biochem Biophys Res Commun251, 688-692. PubMed  Europe PubMed DOI
    49. 1997
  49. Johnston,S.C., Larsen,C.N., Cook,W.J., Wilkinson,K.D. and Hill,C.P.
    Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution
    EMBO J16, 3787-3796. PubMed  Europe PubMed DOI  S
  50. Pilon,A., Yost,P., Chase,T.E., Lohnas,G., Burkett,T., Roberts,S. and Bentley,W.E.
    Ubiquitin fusion technology: bioprocessing of peptides
    Biotechnol Prog13, 374-379. PubMed  Europe PubMed DOI
    51. 1996
  51. Larsen,C.N., Price,J.S. and Wilkinson,K.D.
    Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues
    Biochemistry35, 6735-6744. PubMed  Europe PubMed DOI
    52. 1995
  52. Potempa,J., Pavloff,N. and Travis,J.
    Porphyromonas gingivalis: a proteinase/gene accounting audit
    Trends Microbiol3, 430-434. PubMed  Europe PubMed DOI

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