Summary for peptidase C03.021: rhinovirus picornain 2A

Names
MEROPS Name	rhinovirus picornain 2A
Other names	human rhinovirus protease 2A, picornain 2A (human rhinovirus)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C3 >> Subfamily B >> C03.021
Holotype	rhinovirus picornain 2A (human rhinovirus 2), Uniprot accession P04936 (peptidase unit: 849-996), MERNUM MER0000781
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00086
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (6 cleavages)
Physiology	Viral polyprotein processing in replication.
Pharmaceutical relevance	Potential drug target for human common cold.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	li/ts/t/aG/pa/ps/- (based on 12 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	2	1	0	9	0	0	2
Pro	1	0	1	0	0	5	3	1
Ala	1	0	0	4	2	3	1	2
Val	2	0	0	1	1	1	1	0
Leu	4	1	0	1	0	0	0	2
Ile	3	0	0	0	0	0	0	0
Met	0	0	1	0	0	0	0	0
Phe	0	0	0	0	0	0	0	0
Tyr	0	0	0	1	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	1	3	2	1	0	1	3	0
Thr	0	4	5	2	0	0	2	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	2	0	0	1	0	0
Gln	0	0	0	0	0	0	0	1
Asp	0	1	0	0	0	0	0	1
Glu	0	0	0	0	0	0	0	0
Lys	0	1	0	0	0	0	0	0
Arg	0	0	0	2	0	0	2	2
His	0	0	0	0	0	1	0	0