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Literature for peptidase C03.021: rhinovirus picornain 2A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Deutschmann-Olek,K.M., Yue,W.W., Bezerra,G.A. and Skern,T.
    Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk
    Virology (2021) 562, 128-141. PubMed  Europe PubMed DOI
    2. 2020
  2. Jain,S., Amin,S.A., Adhikari,N., Jha,T. and Gayen,S.
    Good and bad molecular fingerprints for human rhinovirus 3C protease inhibition: identification, validation, and application in designing of new inhibitors through Monte Carlo-based QSAR study
    J Biomol Struct Dyn (2020) 38, 66-77. PubMed  Europe PubMed DOI  I
  3. Smart,D., Filippi,I., Blume,C., Smalley,B., Davies,D. and McCormick,C.J.
    Rhinovirus 2A is the key protease responsible for instigating the early block to gene expression in infected cells
    J Cell Sci (2020) 133, jcs232504-jcs232504. PubMed  Europe PubMed DOI
    4. 2018
  4. Ling,H., Yang,P., Hou,H. and Sun,Y.
    Structural view of the 2A protease from human rhinovirus C15
    Acta Crystallogr F Struct Biol Commun (2018) 74, 255-261. PubMed  Europe PubMed DOI  S
    5. 2017
  5. Aumayr,M., Schrempf,A., Uzulmez,O., Olek,K.M. and Skern,T.
    Interaction of 2A proteinase of human rhinovirus genetic group A with eIF4E is required for eIF4G cleavage during infection
    Virology (2017) 511, 123-134. PubMed  Europe PubMed DOI
  6. Watters,K., Inankur,B., Gardiner,J.C., Warrick,J., Sherer,N.M., Yin,J. and Palmenberg,A.C.
    Differential disruption of nucleocytoplasmic trafficking pathways by rhinovirus 2A proteases
    J Virol (2017) 91, e02472-16-e02472-16. PubMed  Europe PubMed DOI
    7. 2016
  7. Walker,E., Jensen,L., Croft,S., Wei,K., Fulcher,A.J., Jans,D.A. and Ghildyal,R.
    Rhinovirus 16 2A protease affects nuclear localization of 3CD during infection
    J Virol (2016) 90, 11032-11042. PubMed  Europe PubMed DOI
    8. 2015
  8. Aumayr,M., Fedosyuk,S., Ruzicska,K., Sousa-Blin,C., Kontaxis,G. and Skern,T.
    NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII
    Protein Sci (2015) 24, 1979-1996. PubMed  Europe PubMed DOI
  9. Jensen,L.M., Walker,E.J., Jans,D.A. and Ghildyal,R.
    Proteases of human rhinovirus: role in infection
    Methods Mol Biol (2015) 1221, 129-141. PubMed  Europe PubMed DOI  V
  10. Park,N., Schweers,N.J. and Gustin,K.E.
    Selective removal of FG repeat domains from the nuclear pore complex by enterovirus 2A(pro)
    J Virol (2015) 89, 11069-11079. PubMed  Europe PubMed DOI
    11. 2014
  11. Lee,W., Watters,K.E., Troupis,A.T., Reinen,N.M., Suchy,F.P., Moyer,K.L., Frederick,R.O., Tonelli,M., Aceti,D.J., Palmenberg,A.C. and Markley,J.L.
    Solution structure of the 2A protease from a common cold agent, human rhinovirus C2, strain W12
    PLoS ONE (2014) 9, e97198-e97198. PubMed  Europe PubMed DOI  PMC  EPMC  S
    12. 2013
  12. Neubauer,D., Aumayr,M., Gosler,I. and Skern,T.
    Specificity of human rhinovirus 2A(pro) is determined by combined spatial properties of four cleavage site residues
    J Gen Virol (2013) 94, 1535-1546. PubMed  Europe PubMed DOI  P
  13. Walker,E.J., Younessi,P., Fulcher,A.J., McCuaig,R., Thomas,B.J., Bardin,P.G., Jans,D.A. and Ghildyal,R.
    Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells
    PLoS ONE (2013) 8, e71316-e71316. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2012
  14. Falah,N., Violot,S., Decimo,D., Berri,F., Foucault-Grunenwald,M.L., Ohlmann,T., Schuffenecker,I., Morfin,F., Lina,B., Riteau,B. and Cortay,J.C.
    Ex vivo and in vivo inhibition of human rhinovirus replication by a new pseudosubstrate of viral 2A protease
    J Virol (2012) 86, 691-704. PubMed  Europe PubMed DOI  I
  15. Skern,T.
    Picornain 2A
    [ISSN:978-0-12-407743-0] (2012) 3, 2406-2411. DOI
    16. 2011
  16. Watters,K. and Palmenberg,A.C.
    Differential processing of nuclear pore complex proteins by rhinovirus 2A proteases from different species and serotypes
    J Virol (2011) 85, 10874-10883. PubMed  Europe PubMed DOI  P
    17. 2010
  17. Park,N., Skern,T. and Gustin,K.E.
    Specific cleavage of the nuclear pore complex protein Nup62 by a viral protease
    J Biol Chem (2010) 285, 28796-28805. PubMed  Europe PubMed DOI  P
  18. Singh,M., Lee,S.H., Porter,P., Xu,C., Ohno,A., Atmar,R.L., Greenberg,S.B., Bandi,V., Gern,J., Amineva,S., Aminev,A., Skern,T., Smithwick,P., Perusich,S., Barrow,N., Roberts,L., Corry,D.B. and Kheradmand,F.
    Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease
    J Allergy Clin Immunol (2010) 125, 1369-1378. PubMed  Europe PubMed DOI
    19. 2006
  19. Deszcz,L., Cencic,R., Sousa,C., Kuechler,E. and Skern,T.
    An antiviral peptide inhibitor that is active against picornavirus 2A proteinases but not cellular caspases
    J Virol (2006) 80, 9619-9627. PubMed  Europe PubMed DOI  I
  20. [YEAR:20-9-2006]Sousa,C., Schmid,E.M. and Skern,T.
    Defining residues involved in human rhinovirus 2A proteinase substrate recognition
    FEBS Lett (20-9-2006) 580, 5713-5717. PubMed  Europe PubMed DOI  P
    21. 2004
  21. Skern,T.
    Picornain 2A
    [ISSN:0-12-079610-4] (2004) 2, 1361-1365.  V
    22. 2003
  22. [YEAR:29-8-2003]Foeger,N., Schmid,E.M. and Skern,T.
    Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite
    J Biol Chem (29-8-2003) 278, 33200-33207. PubMed  Europe PubMed DOI
  23. Glaser,W., Triendl,A. and Skern,T.
    The processing of eIF4GI by human rhinovirus type 2 2A(pro): relationship to self-cleavage and role of zinc
    J Virol (2003) 77, 5021-5025. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Gradi,A., Svitkin,Y.V., Sommergruber,W., Imataka,H., Morino,S., Skern,T. and Sonenberg,N.
    Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different
    J Virol (2003) 77, 5026-5029. PubMed  Europe PubMed DOI  PMC  EPMC  P
    25. 2002
  25. [YEAR:17-7-2002]Liebig,H.D., Seipelt,J., Vassilieva,E., Gradi,A. and Kuechler,E.
    A thermosensitive mutant of HRV2 2A proteinase: evidence for direct cleavage of eIF4GI and eIF4GII
    FEBS Lett (17-7-2002) 523, 53-57. PubMed  Europe PubMed DOI
    26. 2000
  26. [YEAR:1-9-2000]Glaser,W. and Skern,T.
    Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro
    FEBS Lett (1-9-2000) 480, 151-155. PubMed  Europe PubMed DOI
  27. [YEAR:22-9-2000]Sarkany,Z., Skern,T. and Polgar,L.
    Characterization of the active site thiol group of rhinovirus 2A proteinase
    FEBS Lett (22-9-2000) 481, 289-292. PubMed  Europe PubMed DOI  I
  28. [YEAR:30-6-2000]Seipelt,J., Liebig,H.D., Sommergruber,W., Gerner,C. and Kuechler,E.
    2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells
    J Biol Chem (30-6-2000) 275, 20084-20089. PubMed  Europe PubMed DOI
    29. 1999
  29. [YEAR:15-10-1999]Petersen,J.F., Cherney,M.M., Liebig,H.D., Skern,T., Kuechler,E. and James,M.N.
    The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis
    EMBO J (15-10-1999) 18, 5463-5475. PubMed  Europe PubMed DOI  PMC  EPMC  S
  30. Seipelt,J., Guarne,A., Bergmann,E., James,M., Sommergruber,W., Fita,I. and Skern,T.
    The structures of picornaviral proteinases
    Virus Res (1999) 62, 159-168. PubMed  Europe PubMed DOI
  31. Wang,Q.M.
    Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections
    Prog Drug Res (1999) 52, 197-219. PubMed  Europe PubMed  T
    32. 1998
  32. [YEAR:1-8-1998]Wang,Q.M., Johnson,R.B., Sommergruber,W. and Shepherd,T.A.
    Development of in vitro peptide substrates for human rhinovirus-14 2A protease
    Arch Biochem Biophys (1-8-1998) 356, 12-18. PubMed  Europe PubMed DOI
  33. Wang,Q.M., Johnson,R.B., Cox,G.A., Villarreal,E.C., Churgay,L.M. and Hale,J.E.
    Enzymatic characterization of refolded human rhinovirus type 14 2A protease expressed in Escherichia coli
    J Virol (1998) 72, 1683-1687. PubMed  Europe PubMed  PMC  EPMC  E
    34. 1997
  34. Sommergruber,W., Seipelt,J., Fessl,F., Skern,T., Liebig,H.D. and Casari,G.
    Mutational analyses support a model for the HRV2 2A proteinase
    Virology (1997) 234, 203-214. PubMed  Europe PubMed DOI
  35. Wang,Q.M., Sommergruber,W. and Johnson,R.B.
    Cleavage specificity of human rhinovirus-2 2A protease for peptide substrates
    Biochem Biophys Res Commun (1997) 235, 562-566. PubMed  Europe PubMed DOI
    36. 1996
  36. Haghighat,A., Svitkin,Y., Novoa,I., Kuechler,E., Skern,T. and Sonenberg,N.
    The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase
    J Virol (1996) 70, 8444-8450. PubMed  Europe PubMed  PMC  EPMC
  37. Lamphear,B.J. and Rhoads,R.E.
    A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases
    Biochemistry (1996) 35, 15726-15733. PubMed  Europe PubMed DOI
    38. 1994
  38. Sommergruber,W., Ahorn,H., Klump,H., Seipelt,J., Zoephel,A., Fessl,F., Krystek,E., Blaas,D., Kuechler,E., Liebig,H.D. and Skern,T.
    2A proteinases of coxsackie- and rhinovirus cleave peptides derived from eIF-4 gamma via a common recognition motif
    Virology (1994) 198, 741-745. PubMed  Europe PubMed
    39. 1993
  39. [YEAR:27-7-1993]Liebig,H.D., Ziegler,E., Yan,R., Hartmuth,K., Klump,H., Kowalski,H., Blaas,D., Sommergruber,W., Frasel,L. and Lamphear,B.
    Purification of two picornaviral 2A proteinases: interaction with eIF-4 gamma and influence on in vitro translation
    Biochemistry (27-7-1993) 32, 7581-7588. PubMed  Europe PubMed
  40. Molla,A., Hellen,C.U. and Wimmer,E.
    Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors
    J Virol (1993) 67, 4688-4695. PubMed  Europe PubMed  PMC  EPMC  I
    41. 1992
  41. Luderer,M., Liebig,H.D., Sommergruber,W., Blaas,D., Kuechler,E. and Skern,T.
    Using proteinase trapping to detect revertants of inactive rhinoviral 2A proteinase mutants
    Biol Chem Hoppe Seyler (1992) 373, 523-528. PubMed  Europe PubMed
  42. Sommergruber,W., Ahorn,H., Zophel,A., Maurer-Fogy,I., Fessl,F., Schnorrenberg,G., Liebig,H.D., Blaas,D., Kuechler,E. and Skern,T.
    Cleavage specificity on synthetic peptide substrates of human rhinovirus 2 proteinase 2A
    J Biol Chem (1992) 267, 22639-22644. PubMed  Europe PubMed
    43. 1989
  43. Sommergruber,W., Zorn,M., Blaas,D., Fessl,F., Volkmann,P., MaurerFogy,I., Pallai,P., Merluzzi,V., Matteo,M., Skern,T. and Kuechler,E.
    Polypeptide 2A of human rhinovirus type 2: identification as a protease and characterization by mutational analysis
    Virology (1989) 169, 68-77. PubMed  Europe PubMed

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