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Literature for peptidase C03.021: rhinovirus picornain 2A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Deutschmann-Olek,K.M., Yue,W.W., Bezerra,G.A. and Skern,T.<br>Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk<br>Virology (2021) 562, 128-141. PubMed  Europe PubMed DOI
    2. 2020
  2. Jain,S., Amin,S.A., Adhikari,N., Jha,T. and Gayen,S.<br>Good and bad molecular fingerprints for human rhinovirus 3C protease inhibition: identification, validation, and application in designing of new inhibitors through Monte Carlo-based QSAR study<br>J Biomol Struct Dyn (2020) 38, 66-77. PubMed  Europe PubMed DOI  I
  3. Smart,D., Filippi,I., Blume,C., Smalley,B., Davies,D. and McCormick,C.J.<br>Rhinovirus 2A is the key protease responsible for instigating the early block to gene expression in infected cells<br>J Cell Sci (2020) 133, jcs232504-jcs232504. PubMed  Europe PubMed DOI
    4. 2018
  4. Ling,H., Yang,P., Hou,H. and Sun,Y.<br>Structural view of the 2A protease from human rhinovirus C15<br>Acta Crystallogr F Struct Biol Commun (2018) 74, 255-261. PubMed  Europe PubMed DOI  S
    5. 2017
  5. Aumayr,M., Schrempf,A., Uzulmez,O., Olek,K.M. and Skern,T.<br>Interaction of 2A proteinase of human rhinovirus genetic group A with eIF4E is required for eIF4G cleavage during infection<br>Virology (2017) 511, 123-134. PubMed  Europe PubMed DOI
  6. Watters,K., Inankur,B., Gardiner,J.C., Warrick,J., Sherer,N.M., Yin,J. and Palmenberg,A.C.<br>Differential disruption of nucleocytoplasmic trafficking pathways by rhinovirus 2A proteases<br>J Virol (2017) 91, e02472-16-e02472-16. PubMed  Europe PubMed DOI
    7. 2016
  7. Walker,E., Jensen,L., Croft,S., Wei,K., Fulcher,A.J., Jans,D.A. and Ghildyal,R.<br>Rhinovirus 16 2A protease affects nuclear localization of 3CD during infection<br>J Virol (2016) 90, 11032-11042. PubMed  Europe PubMed DOI
    8. 2015
  8. Aumayr,M., Fedosyuk,S., Ruzicska,K., Sousa-Blin,C., Kontaxis,G. and Skern,T.<br>NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII<br>Protein Sci (2015) 24, 1979-1996. PubMed  Europe PubMed DOI
  9. Jensen,L.M., Walker,E.J., Jans,D.A. and Ghildyal,R.<br>Proteases of human rhinovirus: role in infection<br>Methods Mol Biol (2015) 1221, 129-141. PubMed  Europe PubMed DOI  V
  10. Park,N., Schweers,N.J. and Gustin,K.E.<br>Selective removal of FG repeat domains from the nuclear pore complex by enterovirus 2A(pro)<br>J Virol (2015) 89, 11069-11079. PubMed  Europe PubMed DOI
    11. 2014
  11. Lee,W., Watters,K.E., Troupis,A.T., Reinen,N.M., Suchy,F.P., Moyer,K.L., Frederick,R.O., Tonelli,M., Aceti,D.J., Palmenberg,A.C. and Markley,J.L.<br>Solution structure of the 2A protease from a common cold agent, human rhinovirus C2, strain W12<br>PLoS ONE (2014) 9, e97198-e97198. PubMed  Europe PubMed DOI  PMC  EPMC  S
    12. 2013
  12. Neubauer,D., Aumayr,M., Gosler,I. and Skern,T.<br>Specificity of human rhinovirus 2A(pro) is determined by combined spatial properties of four cleavage site residues<br>J Gen Virol (2013) 94, 1535-1546. PubMed  Europe PubMed DOI  P
  13. Walker,E.J., Younessi,P., Fulcher,A.J., McCuaig,R., Thomas,B.J., Bardin,P.G., Jans,D.A. and Ghildyal,R.<br>Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells<br>PLoS ONE (2013) 8, e71316-e71316. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2012
  14. Falah,N., Violot,S., Decimo,D., Berri,F., Foucault-Grunenwald,M.L., Ohlmann,T., Schuffenecker,I., Morfin,F., Lina,B., Riteau,B. and Cortay,J.C.<br>Ex vivo and in vivo inhibition of human rhinovirus replication by a new pseudosubstrate of viral 2A protease<br>J Virol (2012) 86, 691-704. PubMed  Europe PubMed DOI  I
  15. Skern,T.<br>Picornain 2A<br>[ISSN:978-0-12-407743-0] (2012) 3, 2406-2411. DOI
    16. 2011
  16. Watters,K. and Palmenberg,A.C.<br>Differential processing of nuclear pore complex proteins by rhinovirus 2A proteases from different species and serotypes<br>J Virol (2011) 85, 10874-10883. PubMed  Europe PubMed DOI  P
    17. 2010
  17. Park,N., Skern,T. and Gustin,K.E.<br>Specific cleavage of the nuclear pore complex protein Nup62 by a viral protease<br>J Biol Chem (2010) 285, 28796-28805. PubMed  Europe PubMed DOI  P
  18. Singh,M., Lee,S.H., Porter,P., Xu,C., Ohno,A., Atmar,R.L., Greenberg,S.B., Bandi,V., Gern,J., Amineva,S., Aminev,A., Skern,T., Smithwick,P., Perusich,S., Barrow,N., Roberts,L., Corry,D.B. and Kheradmand,F.<br>Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease<br>J Allergy Clin Immunol (2010) 125, 1369-1378. PubMed  Europe PubMed DOI
    19. 2006
  19. Deszcz,L., Cencic,R., Sousa,C., Kuechler,E. and Skern,T.<br>An antiviral peptide inhibitor that is active against picornavirus 2A proteinases but not cellular caspases<br>J Virol (2006) 80, 9619-9627. PubMed  Europe PubMed DOI  I
  20. [YEAR:20-9-2006]Sousa,C., Schmid,E.M. and Skern,T.<br>Defining residues involved in human rhinovirus 2A proteinase substrate recognition<br>FEBS Lett (20-9-2006) 580, 5713-5717. PubMed  Europe PubMed DOI  P
    21. 2004
  21. Skern,T.<br>Picornain 2A<br>[ISSN:0-12-079610-4] (2004) 2, 1361-1365.  V
    22. 2003
  22. [YEAR:29-8-2003]Foeger,N., Schmid,E.M. and Skern,T.<br>Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite<br>J Biol Chem (29-8-2003) 278, 33200-33207. PubMed  Europe PubMed DOI
  23. Glaser,W., Triendl,A. and Skern,T.<br>The processing of eIF4GI by human rhinovirus type 2 2A(pro): relationship to self-cleavage and role of zinc<br>J Virol (2003) 77, 5021-5025. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Gradi,A., Svitkin,Y.V., Sommergruber,W., Imataka,H., Morino,S., Skern,T. and Sonenberg,N.<br>Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different<br>J Virol (2003) 77, 5026-5029. PubMed  Europe PubMed DOI  PMC  EPMC  P
    25. 2002
  25. [YEAR:17-7-2002]Liebig,H.D., Seipelt,J., Vassilieva,E., Gradi,A. and Kuechler,E.<br>A thermosensitive mutant of HRV2 2A proteinase: evidence for direct cleavage of eIF4GI and eIF4GII<br>FEBS Lett (17-7-2002) 523, 53-57. PubMed  Europe PubMed DOI
    26. 2000
  26. [YEAR:1-9-2000]Glaser,W. and Skern,T.<br>Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro<br>FEBS Lett (1-9-2000) 480, 151-155. PubMed  Europe PubMed DOI
  27. [YEAR:22-9-2000]Sarkany,Z., Skern,T. and Polgar,L.<br>Characterization of the active site thiol group of rhinovirus 2A proteinase<br>FEBS Lett (22-9-2000) 481, 289-292. PubMed  Europe PubMed DOI  I
  28. [YEAR:30-6-2000]Seipelt,J., Liebig,H.D., Sommergruber,W., Gerner,C. and Kuechler,E.<br>2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells<br>J Biol Chem (30-6-2000) 275, 20084-20089. PubMed  Europe PubMed DOI
    29. 1999
  29. [YEAR:15-10-1999]Petersen,J.F., Cherney,M.M., Liebig,H.D., Skern,T., Kuechler,E. and James,M.N.<br>The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis<br>EMBO J (15-10-1999) 18, 5463-5475. PubMed  Europe PubMed DOI  PMC  EPMC  S
  30. Seipelt,J., Guarne,A., Bergmann,E., James,M., Sommergruber,W., Fita,I. and Skern,T.<br>The structures of picornaviral proteinases<br>Virus Res (1999) 62, 159-168. PubMed  Europe PubMed DOI
  31. Wang,Q.M.<br>Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections<br>Prog Drug Res (1999) 52, 197-219. PubMed  Europe PubMed  T
    32. 1998
  32. [YEAR:1-8-1998]Wang,Q.M., Johnson,R.B., Sommergruber,W. and Shepherd,T.A.<br>Development of in vitro peptide substrates for human rhinovirus-14 2A protease<br>Arch Biochem Biophys (1-8-1998) 356, 12-18. PubMed  Europe PubMed DOI
  33. Wang,Q.M., Johnson,R.B., Cox,G.A., Villarreal,E.C., Churgay,L.M. and Hale,J.E.<br>Enzymatic characterization of refolded human rhinovirus type 14 2A protease expressed in Escherichia coli<br>J Virol (1998) 72, 1683-1687. PubMed  Europe PubMed  PMC  EPMC  E
    34. 1997
  34. Sommergruber,W., Seipelt,J., Fessl,F., Skern,T., Liebig,H.D. and Casari,G.<br>Mutational analyses support a model for the HRV2 2A proteinase<br>Virology (1997) 234, 203-214. PubMed  Europe PubMed DOI
  35. Wang,Q.M., Sommergruber,W. and Johnson,R.B.<br>Cleavage specificity of human rhinovirus-2 2A protease for peptide substrates<br>Biochem Biophys Res Commun (1997) 235, 562-566. PubMed  Europe PubMed DOI
    36. 1996
  36. Haghighat,A., Svitkin,Y., Novoa,I., Kuechler,E., Skern,T. and Sonenberg,N.<br>The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase<br>J Virol (1996) 70, 8444-8450. PubMed  Europe PubMed  PMC  EPMC
  37. Lamphear,B.J. and Rhoads,R.E.<br>A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases<br>Biochemistry (1996) 35, 15726-15733. PubMed  Europe PubMed DOI
    38. 1994
  38. Sommergruber,W., Ahorn,H., Klump,H., Seipelt,J., Zoephel,A., Fessl,F., Krystek,E., Blaas,D., Kuechler,E., Liebig,H.D. and Skern,T.<br>2A proteinases of coxsackie- and rhinovirus cleave peptides derived from eIF-4 gamma via a common recognition motif<br>Virology (1994) 198, 741-745. PubMed  Europe PubMed
    39. 1993
  39. [YEAR:27-7-1993]Liebig,H.D., Ziegler,E., Yan,R., Hartmuth,K., Klump,H., Kowalski,H., Blaas,D., Sommergruber,W., Frasel,L. and Lamphear,B.<br>Purification of two picornaviral 2A proteinases: interaction with eIF-4 gamma and influence on in vitro translation<br>Biochemistry (27-7-1993) 32, 7581-7588. PubMed  Europe PubMed
  40. Molla,A., Hellen,C.U. and Wimmer,E.<br>Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors<br>J Virol (1993) 67, 4688-4695. PubMed  Europe PubMed  PMC  EPMC  I
    41. 1992
  41. Luderer,M., Liebig,H.D., Sommergruber,W., Blaas,D., Kuechler,E. and Skern,T.<br>Using proteinase trapping to detect revertants of inactive rhinoviral 2A proteinase mutants<br>Biol Chem Hoppe Seyler (1992) 373, 523-528. PubMed  Europe PubMed
  42. Sommergruber,W., Ahorn,H., Zophel,A., Maurer-Fogy,I., Fessl,F., Schnorrenberg,G., Liebig,H.D., Blaas,D., Kuechler,E. and Skern,T.<br>Cleavage specificity on synthetic peptide substrates of human rhinovirus 2 proteinase 2A<br>J Biol Chem (1992) 267, 22639-22644. PubMed  Europe PubMed
    43. 1989
  43. Sommergruber,W., Zorn,M., Blaas,D., Fessl,F., Volkmann,P., MaurerFogy,I., Pallai,P., Merluzzi,V., Matteo,M., Skern,T. and Kuechler,E.<br>Polypeptide 2A of human rhinovirus type 2: identification as a protease and characterization by mutational analysis<br>Virology (1989) 169, 68-77. PubMed  Europe PubMed

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