$VAR1 = undef;

Summary for peptidase C01.033: cathepsin L1 (Fasciola sp.)

Names
MEROPS Name	cathepsin L1 (Fasciola sp.)
Other names	CL1, FheCL1, FhPcW1 (Fasciola hepatica), FhCL1

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.033
Holotype	cathepsin L1 (Fasciola sp.) (Fasciola gigantica) (peptidase unit: 107-323), MERNUM MER0002418
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00061
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (180 cleavages)
Physiology	Nutrition of organism.
Pharmaceutical relevance	Potential drug target for liver fluke infection. Detection of antibodies has value in diagnosis of infection.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/--/-/-/- (based on 196 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	14	12	8	17	15	13	14	15
Pro	11	8	12	7	8	11	14	11
Ala	22	22	23	23	25	21	20	23
Val	17	14	26	14	14	21	15	24
Leu	18	20	37	24	25	19	27	25
Ile	1	1	0	0	0	1	0	1
Met	2	4	3	3	4	2	0	1
Phe	11	12	16	7	7	12	11	10
Tyr	4	2	1	3	4	3	5	3
Trp	0	1	3	3	2	1	3	2
Ser	11	8	10	16	11	11	11	12
Thr	10	10	13	12	12	8	11	10
Cys	2	3	3	0	5	4	3	2
Asn	8	8	6	8	11	6	9	7
Gln	2	5	0	2	1	3	2	3
Asp	15	14	7	9	9	12	8	13
Glu	11	9	8	10	9	10	6	7
Lys	11	16	12	14	13	13	16	8
Arg	4	6	2	11	4	7	4	2
His	13	12	5	12	11	12	11	11