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Literature for peptidase C01.033: cathepsin L1 (Fasciola sp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, I Inhibitor, E Expression, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chansap,S., Cheukamud,W., Suthisintong,T., Kueakhai,P. and Changklungmoa,N.
    Development of multi-epitope Cathepsin L driven short peptide vaccine against Fasciola gigantica
    Front Vet Sci (2025) 12, 1547937-1547937. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Suksomboon,P., Rattanasroi,K., Osotprasit,S., Chansap,S., Prachasuphap,A., Dhepakson,P., Kueakhai,P. and Changklungmoa,N.
    Construction, expression, and characterization of scFv fragment against Fasciola gigantica cathepsin L1H
    Parasitol Res (2025) 124, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Alhassan,H.H., Ullah,M.I., Niazy,A.A., Alzarea,S.I., Alsaidan,O.A., Alzarea,A.I., Alsaidan,A.A., Alhassan,A.A., Alruwaili,M. and Alruwaili,Y.S.
    Exploring glutathione transferase and Cathepsin L-like proteinase for designing of epitopes-based vaccine against Fasciola hepatica by immunoinformatics and biophysics studies
    Front Immunol (2024) 15, 1478107-1478107. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Gong,J.Z., Huang,J.J., Pan,M., Jin,Q.W., Fan,Y.M., Shi,W.Q. and Huang,S.Y.
    Cathepsin L of Fasciola hepatica meliorates colitis by altering the gut microbiome and inflammatory macrophages
    Int J Biol Macromol (2024) , 138270-138270. PubMed  Europe PubMed DOI
    5. 2023
  5. Artia,Z., Ferraro,F., Sanchez,C., Cerecetto,H., Gil,J., Pareja,L., Alonzo,M.N., Freire,T., Cabrera,M. and Corvo,I.
    In vitro and in vivo studies on a group of chalcones find promising results as potential drugs against fascioliasis
    Exp Parasitol (2023) 255, 108628-108628. PubMed  Europe PubMed DOI
  6. Corrales,J.L., McEvoy,A., Lalor,R., Cwiklinski,K., Doyle,S., Parkinson,M., Keane,O.M., Dalton,J.P. and Dorey,A.L.
    The use of cathepsin L1 (FhCL1) serological ELISA in sentinel screening for liver fluke on sheep farms
    Vet Parasitol Reg Stud Reports (2023) 45, 100924-100924. PubMed  Europe PubMed DOI
  7. Liu,S., Zhang,N., Yu,Q., Li,J., Wang,X., Li,X., Zhang,X., Cheng,S., Yue,T., Zhang,H., Gong,P. and Zhang,X.
    Immunol detection of cathepsin L from Fasciola hepatica infection in sheep by monoclonal antibody-based colloidal gold test strip assay
    Acta Biochim Biophys Sin (Shanghai) (2023) 55, 1668-1671. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Suksomboon,P., Kueakhai,P. and Changklungmoa,N.
    Fasciola gigantica Cathepsin L1H: High Sensitivity and Specificity of Immunochromatographic Strip Test for Antibody Detection
    Trop Med Infect Dis (2023) 8 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2022
  9. Fereig,R.M., Metwally,S., El-Alfy,E.S., Abdelbaky,H.H., Shanab,O., Omar,M.A. and Alsayeqh,A.F.
    High relatedness of bioinformatic data and realistic experimental works on the potentials of Fasciola hepatica and F. gigantica cathepsin L1 as a diagnostic and vaccine antigen
    Front Public Health (2022) 10, 1054502-1054502. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Cwiklinski,K., Robinson,M.W., Donnelly,S. and Dalton,J.P.
    Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver
    BMC Genomics (2021) 22, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Sugiyama,T., Ichikawa-Seki,M., Sato,H., Kounosu,A., Tanaka,M. and Maruyama,H.
    Enzyme-linked immunosorbent assay (ELISA) using recombinant Fasciola cathepsin L1 for the diagnosis of human fasciolosis caused by Fasciola hepatica/gigantica hybrid type
    Parasitol Int (2021) 82, 102311-102311. PubMed  Europe PubMed DOI
  12. Villa-Mancera,A., Olivares-Perez,J., Olmedo-Juarez,A. and Reynoso-Palomar,A.
    Phage display-based vaccine with cathepsin L and excretory-secretory products mimotopes of Fasciola hepatica induces protective cellular and humoral immune responses in sheep
    Vet Parasitol (2021) 289, 109340-109340. PubMed  Europe PubMed DOI
  13. Villa-Mancera,A., Alcala-Canto,Y., Olivares-Perez,J., Molina-Mendoza,P., Hernandez-Guzman,K., Utrera-Quintana,F., Carreon-Luna,L., Olmedo-Juarez,A. and Reynoso-Palomar,A.
    Vaccination with cathepsin L mimotopes of Fasciola hepatica in goats reduces worm burden, morphometric measurements, and reproductive structures
    Microb Pathog (2021) 155, 104859-104859. PubMed  Europe PubMed DOI
    14. 2020
  14. Aftab,A., Lall,R., Bisen,S., Anandanarayanan,A., Rialch,A., Chamuah,J.K., Yadav,S., Silamparasan,M. and Raina,O.K.
    Serodiagnosis of Fasciola gigantica infection in buffaloes with native cathepsin-L proteases and recombinant cathepsin L1-D
    Acta Parasitol (2020) 65, 413-421. PubMed  Europe PubMed DOI
  15. Buffoni,L., Garza-Cuartero,L., Perez-Caballero,R., Zafra,R., Javier Martinez-Moreno,F., Molina-Hernandez,V., Perez,J., Martinez-Moreno,A. and Mulcahy,G.
    Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach
    Parasit Vectors (2020) 13, 390-390. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Mokhtarian,K., Falak,R. and Heidari,Z.
    Evaluation of Gelatinolytic and Collagenolytic Activity of Fasciola hepatica Recombinant Cathepsin-L1
    Iran J Biotechnol (2020) 18, e2357-e2357. PubMed  Europe PubMed DOI  PMC  EPMC  L
  17. Pritsch,I.C., Tikhonova,I.G., Jewhurst,H.L., Drysdale,O., Cwiklinski,K., Molento,M.B., Dalton,J.P. and Verissimo,C.M.
    Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition
    BMC Mol Cell Biol (2020) 21, 90-90. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Sadaow,L., Yamasaki,H., Morishima,Y., Sanpool,O., Rodpai,R., Janwan,P., Boonroumkaew,P., Maleewong,W. and Intapan,P.M.
    Effectiveness of Fasciola gigantica excretory-secretory and recombinant cathepsin L antigens for rapid diagnosis of human fascioliasis using immunochromatographic devices
    Parasitol Res (2020) 119, 3691-3698. PubMed  Europe PubMed DOI
  19. Sato,H., Hiraya,H., Sugiyama,T., Fukumoto,S., Matsuyama,R., Yanagawa,Y., Nakao,R., Irie,T., Taira,K., Yamazaki,A., Hagiwara,K., Yoshida,A., Kamata,Y. and Ichikawa-Seki,M.
    Seroprevalence of fasciolosis in Hokkaido sika deer (Cervus nippon yesoensis) from Hokkaido Prefecture, Japan revealed by ELISA using recombinant cathepsin L1
    Parasitol Int (2020) 80, 102222-102222. PubMed  Europe PubMed DOI
  20. Smith,D., Cwiklinski,K., Jewhurst,H., Tikhonova,I.G. and Dalton,J.P.
    An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica
    Sci Rep (2020) 10, 20657-20657. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2019
  21. Cwiklinski,K., Donnelly,S., Drysdale,O., Jewhurst,H., Smith,D., De Marco Verissimo,C., Pritsch,I.C., O'Neill,S., Dalton,J.P. and Robinson,M.W.
    The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola
    Adv Parasitol (2019) 104, 113-164. PubMed  Europe PubMed DOI
  22. Ferraro,F., Merlino,A., Gil,J., Cerecetto,H., Corvo,I. and Cabrera,M.
    Cathepsin L inhibitors with activity against the liver fluke identified from a focus library of quinoxaline 1,4-di-N-oxide derivatives
    Molecules (2019) 24 PubMed  Europe PubMed DOI  I
  23. Norbury,L.J., Basalaj,K., Baska,P., Kalinowska,A., Zawistowska-Deniziak,A., Yap,H.Y., Wilkowski,P., Wesolowska,A. and Wedrychowicz,H.
    Construction of a novel phage display antibody library against Fasciola hepatica, and generation of a single-chain variable fragment specific for F. hepatica cathepsin L1
    Exp Parasitol (2019) 198, 87-94. PubMed  Europe PubMed DOI
    24. 2016
  24. Anuracpreeda,P., Chawengkirttikul,R. and Sobhon,P.
    Immunodiagnosis of Fasciola gigantica infection using monoclonal antibody-based sandwich ELISA and immunochromatographic assay for detection of circulating cathepsin L1 protease
    PLoS ONE (2016) 11, e0145650-e0145650. PubMed  Europe PubMed DOI
  25. Ferraro,F., Merlino,A., dellOca,N., Gil,J., Tort,J.F., Gonzalez,M., Cerecetto,H., Cabrera,M. and Corvo,I.
    Identification of chalcones as Fasciola hepatica cathepsin L inhibitors using a comprehensive experimental and computational approach
    PLoS Negl Trop Dis (2016) 10, e0004834-e0004834. PubMed  Europe PubMed DOI  I
  26. Hernandez-Guzman,K., Sahagun-Ruiz,A., Vallecillo,A.J., Cruz-Mendoza,I. and Quiroz-Romero,H.
    Construction and evaluation of a chimeric protein made from Fasciola hepatica leucine aminopeptidase and cathepsin L1
    J Helminthol (2016) 90, 7-13. PubMed  Europe PubMed DOI  E
  27. Mokhtarian,K., Akhlaghi,L., Mohammadi,M., Meamar,A.R., Razmjou,E., Khoshmirsafa,M. and Falak,R.
    Evaluation of anti-cathepsin L1: a more reliable method for serodiagnosis of human fasciolosis
    Trans R Soc Trop Med Hyg (2016) 110, 542-550. PubMed  Europe PubMed DOI
    28. 2015
  28. Meemon,K. and Sobhon,P.
    Juvenile-specific cathepsin proteases in Fasciola spp.: their characteristics and vaccine efficacies
    Parasitol Res (2015) 114, 2807-2813. PubMed  Europe PubMed DOI
  29. Sansri,V., Meemon,K., Changklungmoa,N., Kueakhai,P., Chantree,P., Chaichanasak,P., Lorsuwannarat,N., Itagaki,T. and Sobhon,P.
    Protection against Fasciola gigantica infection in mice by vaccination with recombinant juvenile-specific cathepsin L
    Vaccine (2015) 33, 1596-1601. PubMed  Europe PubMed DOI
  30. Wongwairot,S., Kueakhai,P., Changklungmoa,N., Jaikua,W., Sansri,V., Meemon,K., Songkoomkrong,S., Riengrojpitak,S. and Sobhon,P.
    Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica
    Parasitol Res (2015) 114, 133-140. PubMed  Europe PubMed DOI
    31. 2014
  31. Lustigman,S., Melnikow,E., Anand,S.B., Contreras,A., Nandi,V., Liu,J., Bell,A., Unnasch,T.R., Rogers,M.B. and Ghedin,E.
    Potential involvement of Brugia malayi cysteine proteases in the maintenance of the endosymbiotic relationship with Wolbachia
    Int J Parasitol Drugs Drug Resist (2014) 4, 267-277. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2013
  32. Gonzales Santana,B., Dalton,J.P., Vasquez Camargo,F., Parkinson,M. and Ndao,M.
    The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease
    PLoS Negl Trop Dis (2013) 7, e2414-e2414. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Sansri,V., Changklungmoa,N., Chaichanasak,P., Sobhon,P. and Meemon,K.
    Molecular cloning, characterization and functional analysis of a novel juvenile-specific cathepsin L of Fasciola gigantica
    Acta Trop (2013) 128, 76-84. PubMed  Europe PubMed DOI
  34. Wesolowska,A., Norbury,L.J., Januszkiewicz,K., Jedlina,L., Jaros,S., Zawistowska-Deniziak,A., Zygner,W. and Wedrychowicz,H.
    Evaluation of the immune response of male and female rats vaccinated with cDNA encoding a cysteine proteinase of Fasciola hepatica (FhPcW1)
    Acta Parasitol (2013) 58, 198-206. PubMed  Europe PubMed DOI
    35. 2012
  35. McVeigh,P., Maule,A.G., Dalton,J.P. and Robinson,M.W.
    Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective
    Microbes Infect (2012) 14, 301-310. PubMed  Europe PubMed DOI
  36. Robinson,M.W., Brindley,P.J., McKerrow,J.H. and Dalton,J.P.
    Trematode cysteine endopeptidases
    [ISSN:978-0-12-407743-0] (2012) 3, 1941-1949. DOI
    37. 2011
  37. Morphew,R.M., Wright,H.A., Lacourse,E.J., Porter,J., Barrett,J., Woods,D.J. and Brophy,P.M.
    Towards delineating functions within the Fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics
    PLoS Negl Trop Dis (2011) 5, e937-e937. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Robinson,M.W., Corvo,I., Jones,P.M., George,A.M., Padula,M.P., To,J., Cancela,M., Rinaldi,G., Tort,J.F., Roche,L. and Dalton,J.P.
    Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica
    PLoS Negl Trop Dis (2011) 5, e1012-e1012. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Stack,C., Dalton,J.P. and Robinson,M.W.
    The phylogeny, structure and function of trematode cysteine proteases, with particular emphasis on the Fasciola hepatica cathepsin L family
    Adv Exp Med Biol (2011) 712, 116-135. PubMed  Europe PubMed DOI  V
    40. 2010
  40. Donnelly,S., O'Neill,S.M., Stack,C.M., Robinson,M.W., Turnbull,L., Whitchurch,C. and Dalton,J.P.
    Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3
    J Biol Chem (2010) 285, 3383-3392. PubMed  Europe PubMed DOI
  41. Golden,O., Flynn,R.J., Read,C., Sekiya,M., Donnelly,S.M., Stack,C., Dalton,J.P. and Mulcahy,G.
    Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1)
    Vaccine (2010) 28, 5551-5557. PubMed  Europe PubMed DOI
  42. Jaros,S., Zygner,W., Januszkiewicz,K., Jaros,D. and Wedrychowicz,H.
    Molecular cloning and bioinformatic characterisation of FhPcW1, a new isoform of cathepsin L from adult Fasciola hepatica
    Bull Vet Inst Pulawy (2010) 54, 585-590.
  43. Moran,B.W., Anderson,F.P., Ruth,D.M., Fagain,C.O., Dalton,J.P. and Kenny,P.T.
    Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1
    J Enzyme Inhib Med Chem (2010) 25, 1-12. PubMed  Europe PubMed DOI  I
  44. Perez-Ecija,R.A., Mendes,R.E., Zafra,R., Buffonni,L., Martinez-Moreno,A. and Perez,J.
    Pathological and parasitological protection in goats immunised with recombinant cathepsin L1 and challenged with Fasciola hepatica
    Vet J (2010) 185, 351-353. PubMed  Europe PubMed DOI
    45. 2009
  45. Kasny,M., Mikes,L., Hampl,V., Dvorak,J., Caffrey,C.R., Dalton,J.P. and Horak,P.
    Chapter 4. Peptidases of trematodes
    Adv Parasitol (2009) 69, 205-297. PubMed  Europe PubMed DOI  V
  46. Lowther,J., Robinson,M.W., Donnelly,S.M., Xu,W., Stack,C.M., Matthews,J.M. and Dalton,J.P.
    The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease
    PLoS Negl Trop Dis (2009) 3, e369-e369. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2008
  47. Dixit,A.K., Dixit,P. and Sharma,R.L.
    Immunodiagnostic/protective role of cathepsin L cysteine proteinases secreted by Fasciola species
    Vet Parasitol (2008) 154, 177-184. PubMed  Europe PubMed DOI  T
  48. Jezek,J., El Ridi,R., Salah,M., Wagih,A., Aziz,H.W., Tallima,H., El Shafie,M.H., Khalek,T.A., Ammou,F.F., Strongylis,C., Moussis,V. and Tsikaris,V.
    Fasciola gigantica cathepsin L proteinase-based synthetic peptide for immunodiagnosis and prevention of sheep fasciolosis
    Biopolymers (2008) 90, 349-357. PubMed  Europe PubMed DOI
  49. Kuk,S. and Erensoy,A.
    [Gene cloning, selection of plasmids and application of Fasciola hepatica cathepsin L1 gene]
    Turkiye Parazitol Derg (2008) 32, 16-22. PubMed  Europe PubMed
  50. McGonigle,L., Mousley,A., Marks,N.J., Brennan,G.P., Dalton,J.P., Spithill,T.W., Day,T.A. and Maule,A.G.
    The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration
    Int J Parasitol (2008) 38, 149-155. PubMed  Europe PubMed DOI
  51. Robinson,M.W., Tort,J.F., Lowther,J., Donnelly,S.M., Wong,E., Xu,W., Stack,C.M., Padula,M., Herbert,B. and Dalton,J.P.
    Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors
    Mol Cell Proteomics (2008) 7, 1111-1123. PubMed  Europe PubMed DOI
  52. Robinson,M.W., Dalton,J.P. and Donnelly,S.
    Helminth pathogen cathepsin proteases: it's a family affair
    Trends Biochem Sci (2008) 33, 601-608. PubMed  Europe PubMed DOI  V
  53. Stack,C.M., Caffrey,C.R., Donnelly,S.M., Seshaadri,A., Lowther,J., Tort,J.F., Collins,P.R., Robinson,M.W., Xu,W., McKerrow,J.H., Craik,C.S., Geiger,S.R., Marion,R., Brinen,L.S. and Dalton,J.P.
    Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica
    J Biol Chem (2008) 283, 9896-9908. PubMed  Europe PubMed DOI  S
    54. 2007
  54. Kesik,M., Jedlina-Panasiuk,L., Kozak-Cieszczyk,M., Plucienniczak,A. and Wedrychowicz,H.
    Enteral vaccination of rats against Fasciola hepatica using recombinant cysteine proteinase (cathepsin L1)
    Vaccine (2007) 25, 3619-3628. PubMed  Europe PubMed DOI
  55. Stack,C.M., Donnelly,S., Lowther,J., Xu,W., Collins,P.R., Brinen,L.S. and Dalton,J.P.
    The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: A leu-12 to pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal
    J Biol Chem (2007) 282, 16532-16543. PubMed  Europe PubMed DOI
  56. Wedrychowicz,H., Kesik,M., Kaliniak,M., Kozak-Cieszczyk,M., Jedlina-Panasiuk,L., Jaros,S. and Plucienniczak,A.
    Vaccine potential of inclusion bodies containing cysteine proteinase of Fasciola hepatica in calves and lambs experimentally challenged with metacercariae of the fluke
    Vet Parasitol (2007) 147, 77-88. PubMed  Europe PubMed DOI
    57. 2006
  57. [YEAR:27-4-2006]Raina,O.K., Yadav,S.C., Sriveny,D. and Gupta,S.C.
    Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases
    Acta Trop (27-4-2006) 98, 145-151. PubMed  Europe PubMed DOI
  58. [YEAR:6-7-2006]Ruth,D.M., McMahon,G. and O'Fagain,C.
    Peptide synthesis by recombinant Fasciola hepatica cathepsin L1
    Biochimie (6-7-2006) 88, 117-120. PubMed  Europe PubMed DOI
  59. [YEAR:17-11-2006]Sriveny,D., Raina,O.K., Yadav,S.C., Chandra,D., Jayraw,A.K., Singh,M., Velusamy,R. and Singh,B.P.
    Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection
    Vet Parasitol (17-11-2006) 135, 25-31. PubMed  Europe PubMed DOI
    60. 2005
  60. [YEAR:14-9-2005]Intapan,P.M., Tantrawatpan,C., Maleewong,W., Wongkham,S., Wongkham,C. and Nakashima,K.
    Potent epitopes derived from Fasciola gigantica cathepsin L1 in peptide-based immunoassay for the serodiagnosis of human fascioliasis
    Diagn Microbiol Infect Dis (14-9-2005) 53, 125-129. PubMed  Europe PubMed DOI  A
  61. [YEAR:13-10-2005]Yadav,S.C., Saini,M., Raina,O.K., Nambi,P.A., Jadav,K. and Sriveny,D.
    Fasciola gigantica cathepsin-L cysteine proteinase in the detection of early experimental fasciolosis in ruminants
    Parasitol Res (13-10-2005) 97, 527-534. PubMed  Europe PubMed DOI
    62. 2004
  62. [YEAR:30-1-2004]Collins,P.R., Stack,C.M., O'Neill,S.M., Doyle,S., Ryan,T., Brennan,G.P., Mousley,A., Stewart,M., Maule,A.G., Dalton,J.P. and Donnelly,S.
    Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells
    J Biol Chem (30-1-2004) 279, 17038-17046. PubMed  Europe PubMed DOI
  63. Dalton,J.P., McKerrow,J.H. and Brindley,P.J.
    Trematode cysteine endopeptidases
    [ISSN:0-12-079610-4] (2004) 2, 1176-1182.  V
    64. 2003
  64. [YEAR:30-9-2003]Dalton,J.P., Neill,S.O., Stack,C., Collins,P., Walshe,A., Sekiya,M., Doyle,S., Mulcahy,G., Hoyle,D., Khaznadji,E., Moire,N., Brennan,G., Mousley,A., Kreshchenko,N., Maule,A.G. and Donnelly,S.M.
    Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines
    Int J Parasitol (30-9-2003) 33, 1173-1181. PubMed  Europe PubMed DOI
  65. Irving,J.A., Spithill,T.W., Pike,R.N., Whisstock,J.C. and Smooker,P.M.
    The evolution of enzyme specificity in Fasciola spp
    J Mol Evol (2003) 57, 1-15. PubMed  Europe PubMed DOI
    66. 2002
  66. Cappetta,M., Roth,I., Diaz,A., Tort,J. and Roche,L.
    Role of the prosegment of Fasciola hepatica cathepsin L1 in folding of the catalytic domain
    Biol Chem (2002) 383, 1215-1221. PubMed  Europe PubMed DOI
  67. Sajid,M. and McKerrow,J.H.
    Cysteine proteases of parasitic organisms
    Mol Biochem Parasitol (2002) 120, 1-21. PubMed  Europe PubMed
    68. 2001
  68. Carnevale,S., Rodriguez,M.I., Guarnera,E.A., Carmona,C., Tanos,T. and Angel,S.O.
    Immunodiagnosis of fasciolosis using recombinant procathepsin L cystein proteinase
    Diagn Microbiol Infect Dis (2001) 41, 43-49. PubMed  Europe PubMed DOI
  69. [YEAR:3-9-2001]Cordova,M., Jara,J., Del Nery,E., Hirata,I.Y., Araujo,M.S., Carmona,A.K., Juliano,M.A. and Juliano,L.
    Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity
    Mol Biochem Parasitol (3-9-2001) 116, 109-115. PubMed  Europe PubMed DOI
  70. Grams,R., Vichasri-Grams,S., Sobhon,P., Upatham,E.S. and Viyanant,V.
    Molecular cloning and characterization of cathepsin L encoding genes from Fasciola gigantica
    Parasitol Int (2001) 50, 105-114. PubMed  Europe PubMed DOI
  71. Mulcahy,G. and Dalton,J.P.
    Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants
    Res Vet Sci (2001) 70, 83-86. PubMed  Europe PubMed DOI
  72. O'Neill,S.M., Mills,K.H. and Dalton,J.P.
    Fasciola hepatica cathepsin L cysteine proteinase suppresses Bordetella pertussis-specific interferon-gamma production in vivo
    Parasite Immunol (2001) 23, 541-547. PubMed  Europe PubMed DOI
    73. 2000
  73. Berasain,P., Carmona,C., Frangione,B., Dalton,J.P. and Goni,F.
    Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced
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