Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C01.033: cathepsin L1 (Fasciola sp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, I Inhibitor, E Expression, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chansap,S., Cheukamud,W., Suthisintong,T., Kueakhai,P. and Changklungmoa,N.<br>Development of multi-epitope Cathepsin L driven short peptide vaccine against Fasciola gigantica<br>Front Vet Sci (2025) 12, 1547937-1547937. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Suksomboon,P., Rattanasroi,K., Osotprasit,S., Chansap,S., Prachasuphap,A., Dhepakson,P., Kueakhai,P. and Changklungmoa,N.<br>Construction, expression, and characterization of scFv fragment against Fasciola gigantica cathepsin L1H<br>Parasitol Res (2025) 124, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Alhassan,H.H., Ullah,M.I., Niazy,A.A., Alzarea,S.I., Alsaidan,O.A., Alzarea,A.I., Alsaidan,A.A., Alhassan,A.A., Alruwaili,M. and Alruwaili,Y.S.<br>Exploring glutathione transferase and Cathepsin L-like proteinase for designing of epitopes-based vaccine against Fasciola hepatica by immunoinformatics and biophysics studies<br>Front Immunol (2024) 15, 1478107-1478107. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Gong,J.Z., Huang,J.J., Pan,M., Jin,Q.W., Fan,Y.M., Shi,W.Q. and Huang,S.Y.<br>Cathepsin L of Fasciola hepatica meliorates colitis by altering the gut microbiome and inflammatory macrophages<br>Int J Biol Macromol (2024) , 138270-138270. PubMed  Europe PubMed DOI
    5. 2023
  5. Artia,Z., Ferraro,F., Sanchez,C., Cerecetto,H., Gil,J., Pareja,L., Alonzo,M.N., Freire,T., Cabrera,M. and Corvo,I.<br>In vitro and in vivo studies on a group of chalcones find promising results as potential drugs against fascioliasis<br>Exp Parasitol (2023) 255, 108628-108628. PubMed  Europe PubMed DOI
  6. Corrales,J.L., McEvoy,A., Lalor,R., Cwiklinski,K., Doyle,S., Parkinson,M., Keane,O.M., Dalton,J.P. and Dorey,A.L.<br>The use of cathepsin L1 (FhCL1) serological ELISA in sentinel screening for liver fluke on sheep farms<br>Vet Parasitol Reg Stud Reports (2023) 45, 100924-100924. PubMed  Europe PubMed DOI
  7. Liu,S., Zhang,N., Yu,Q., Li,J., Wang,X., Li,X., Zhang,X., Cheng,S., Yue,T., Zhang,H., Gong,P. and Zhang,X.<br>Immunol detection of cathepsin L from Fasciola hepatica infection in sheep by monoclonal antibody-based colloidal gold test strip assay<br>Acta Biochim Biophys Sin (Shanghai) (2023) 55, 1668-1671. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Suksomboon,P., Kueakhai,P. and Changklungmoa,N.<br>Fasciola gigantica Cathepsin L1H: High Sensitivity and Specificity of Immunochromatographic Strip Test for Antibody Detection<br>Trop Med Infect Dis (2023) 8 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2022
  9. Fereig,R.M., Metwally,S., El-Alfy,E.S., Abdelbaky,H.H., Shanab,O., Omar,M.A. and Alsayeqh,A.F.<br>High relatedness of bioinformatic data and realistic experimental works on the potentials of Fasciola hepatica and F. gigantica cathepsin L1 as a diagnostic and vaccine antigen<br>Front Public Health (2022) 10, 1054502-1054502. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Cwiklinski,K., Robinson,M.W., Donnelly,S. and Dalton,J.P.<br>Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver<br>BMC Genomics (2021) 22, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Sugiyama,T., Ichikawa-Seki,M., Sato,H., Kounosu,A., Tanaka,M. and Maruyama,H.<br>Enzyme-linked immunosorbent assay (ELISA) using recombinant Fasciola cathepsin L1 for the diagnosis of human fasciolosis caused by Fasciola hepatica/gigantica hybrid type<br>Parasitol Int (2021) 82, 102311-102311. PubMed  Europe PubMed DOI
  12. Villa-Mancera,A., Olivares-Perez,J., Olmedo-Juarez,A. and Reynoso-Palomar,A.<br>Phage display-based vaccine with cathepsin L and excretory-secretory products mimotopes of Fasciola hepatica induces protective cellular and humoral immune responses in sheep<br>Vet Parasitol (2021) 289, 109340-109340. PubMed  Europe PubMed DOI
  13. Villa-Mancera,A., Alcala-Canto,Y., Olivares-Perez,J., Molina-Mendoza,P., Hernandez-Guzman,K., Utrera-Quintana,F., Carreon-Luna,L., Olmedo-Juarez,A. and Reynoso-Palomar,A.<br>Vaccination with cathepsin L mimotopes of Fasciola hepatica in goats reduces worm burden, morphometric measurements, and reproductive structures<br>Microb Pathog (2021) 155, 104859-104859. PubMed  Europe PubMed DOI
    14. 2020
  14. Aftab,A., Lall,R., Bisen,S., Anandanarayanan,A., Rialch,A., Chamuah,J.K., Yadav,S., Silamparasan,M. and Raina,O.K.<br>Serodiagnosis of Fasciola gigantica infection in buffaloes with native cathepsin-L proteases and recombinant cathepsin L1-D<br>Acta Parasitol (2020) 65, 413-421. PubMed  Europe PubMed DOI
  15. Buffoni,L., Garza-Cuartero,L., Perez-Caballero,R., Zafra,R., Javier Martinez-Moreno,F., Molina-Hernandez,V., Perez,J., Martinez-Moreno,A. and Mulcahy,G.<br>Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach<br>Parasit Vectors (2020) 13, 390-390. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Mokhtarian,K., Falak,R. and Heidari,Z.<br>Evaluation of Gelatinolytic and Collagenolytic Activity of Fasciola hepatica Recombinant Cathepsin-L1<br>Iran J Biotechnol (2020) 18, e2357-e2357. PubMed  Europe PubMed DOI  PMC  EPMC  L
  17. Pritsch,I.C., Tikhonova,I.G., Jewhurst,H.L., Drysdale,O., Cwiklinski,K., Molento,M.B., Dalton,J.P. and Verissimo,C.M.<br>Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition<br>BMC Mol Cell Biol (2020) 21, 90-90. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Sadaow,L., Yamasaki,H., Morishima,Y., Sanpool,O., Rodpai,R., Janwan,P., Boonroumkaew,P., Maleewong,W. and Intapan,P.M.<br>Effectiveness of Fasciola gigantica excretory-secretory and recombinant cathepsin L antigens for rapid diagnosis of human fascioliasis using immunochromatographic devices<br>Parasitol Res (2020) 119, 3691-3698. PubMed  Europe PubMed DOI
  19. Sato,H., Hiraya,H., Sugiyama,T., Fukumoto,S., Matsuyama,R., Yanagawa,Y., Nakao,R., Irie,T., Taira,K., Yamazaki,A., Hagiwara,K., Yoshida,A., Kamata,Y. and Ichikawa-Seki,M.<br>Seroprevalence of fasciolosis in Hokkaido sika deer (Cervus nippon yesoensis) from Hokkaido Prefecture, Japan revealed by ELISA using recombinant cathepsin L1<br>Parasitol Int (2020) 80, 102222-102222. PubMed  Europe PubMed DOI
  20. Smith,D., Cwiklinski,K., Jewhurst,H., Tikhonova,I.G. and Dalton,J.P.<br>An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica<br>Sci Rep (2020) 10, 20657-20657. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2019
  21. Cwiklinski,K., Donnelly,S., Drysdale,O., Jewhurst,H., Smith,D., De Marco Verissimo,C., Pritsch,I.C., O'Neill,S., Dalton,J.P. and Robinson,M.W.<br>The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola<br>Adv Parasitol (2019) 104, 113-164. PubMed  Europe PubMed DOI
  22. Ferraro,F., Merlino,A., Gil,J., Cerecetto,H., Corvo,I. and Cabrera,M.<br>Cathepsin L inhibitors with activity against the liver fluke identified from a focus library of quinoxaline 1,4-di-N-oxide derivatives<br>Molecules (2019) 24 PubMed  Europe PubMed DOI  I
  23. Norbury,L.J., Basalaj,K., Baska,P., Kalinowska,A., Zawistowska-Deniziak,A., Yap,H.Y., Wilkowski,P., Wesolowska,A. and Wedrychowicz,H.<br>Construction of a novel phage display antibody library against Fasciola hepatica, and generation of a single-chain variable fragment specific for F. hepatica cathepsin L1<br>Exp Parasitol (2019) 198, 87-94. PubMed  Europe PubMed DOI
    24. 2016
  24. Anuracpreeda,P., Chawengkirttikul,R. and Sobhon,P.<br>Immunodiagnosis of Fasciola gigantica infection using monoclonal antibody-based sandwich ELISA and immunochromatographic assay for detection of circulating cathepsin L1 protease<br>PLoS ONE (2016) 11, e0145650-e0145650. PubMed  Europe PubMed DOI
  25. Ferraro,F., Merlino,A., dellOca,N., Gil,J., Tort,J.F., Gonzalez,M., Cerecetto,H., Cabrera,M. and Corvo,I.<br>Identification of chalcones as Fasciola hepatica cathepsin L inhibitors using a comprehensive experimental and computational approach<br>PLoS Negl Trop Dis (2016) 10, e0004834-e0004834. PubMed  Europe PubMed DOI  I
  26. Hernandez-Guzman,K., Sahagun-Ruiz,A., Vallecillo,A.J., Cruz-Mendoza,I. and Quiroz-Romero,H.<br>Construction and evaluation of a chimeric protein made from Fasciola hepatica leucine aminopeptidase and cathepsin L1<br>J Helminthol (2016) 90, 7-13. PubMed  Europe PubMed DOI  E
  27. Mokhtarian,K., Akhlaghi,L., Mohammadi,M., Meamar,A.R., Razmjou,E., Khoshmirsafa,M. and Falak,R.<br>Evaluation of anti-cathepsin L1: a more reliable method for serodiagnosis of human fasciolosis<br>Trans R Soc Trop Med Hyg (2016) 110, 542-550. PubMed  Europe PubMed DOI
    28. 2015
  28. Meemon,K. and Sobhon,P.<br>Juvenile-specific cathepsin proteases in Fasciola spp.: their characteristics and vaccine efficacies<br>Parasitol Res (2015) 114, 2807-2813. PubMed  Europe PubMed DOI
  29. Sansri,V., Meemon,K., Changklungmoa,N., Kueakhai,P., Chantree,P., Chaichanasak,P., Lorsuwannarat,N., Itagaki,T. and Sobhon,P.<br>Protection against Fasciola gigantica infection in mice by vaccination with recombinant juvenile-specific cathepsin L<br>Vaccine (2015) 33, 1596-1601. PubMed  Europe PubMed DOI
  30. Wongwairot,S., Kueakhai,P., Changklungmoa,N., Jaikua,W., Sansri,V., Meemon,K., Songkoomkrong,S., Riengrojpitak,S. and Sobhon,P.<br>Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica<br>Parasitol Res (2015) 114, 133-140. PubMed  Europe PubMed DOI
    31. 2014
  31. Lustigman,S., Melnikow,E., Anand,S.B., Contreras,A., Nandi,V., Liu,J., Bell,A., Unnasch,T.R., Rogers,M.B. and Ghedin,E.<br>Potential involvement of Brugia malayi cysteine proteases in the maintenance of the endosymbiotic relationship with Wolbachia<br>Int J Parasitol Drugs Drug Resist (2014) 4, 267-277. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2013
  32. Gonzales Santana,B., Dalton,J.P., Vasquez Camargo,F., Parkinson,M. and Ndao,M.<br>The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease<br>PLoS Negl Trop Dis (2013) 7, e2414-e2414. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Sansri,V., Changklungmoa,N., Chaichanasak,P., Sobhon,P. and Meemon,K.<br>Molecular cloning, characterization and functional analysis of a novel juvenile-specific cathepsin L of Fasciola gigantica<br>Acta Trop (2013) 128, 76-84. PubMed  Europe PubMed DOI
  34. Wesolowska,A., Norbury,L.J., Januszkiewicz,K., Jedlina,L., Jaros,S., Zawistowska-Deniziak,A., Zygner,W. and Wedrychowicz,H.<br>Evaluation of the immune response of male and female rats vaccinated with cDNA encoding a cysteine proteinase of Fasciola hepatica (FhPcW1)<br>Acta Parasitol (2013) 58, 198-206. PubMed  Europe PubMed DOI
    35. 2012
  35. McVeigh,P., Maule,A.G., Dalton,J.P. and Robinson,M.W.<br>Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective<br>Microbes Infect (2012) 14, 301-310. PubMed  Europe PubMed DOI
  36. Robinson,M.W., Brindley,P.J., McKerrow,J.H. and Dalton,J.P.<br>Trematode cysteine endopeptidases<br>[ISSN:978-0-12-407743-0] (2012) 3, 1941-1949. DOI
    37. 2011
  37. Morphew,R.M., Wright,H.A., Lacourse,E.J., Porter,J., Barrett,J., Woods,D.J. and Brophy,P.M.<br>Towards delineating functions within the Fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics<br>PLoS Negl Trop Dis (2011) 5, e937-e937. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Robinson,M.W., Corvo,I., Jones,P.M., George,A.M., Padula,M.P., To,J., Cancela,M., Rinaldi,G., Tort,J.F., Roche,L. and Dalton,J.P.<br>Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica<br>PLoS Negl Trop Dis (2011) 5, e1012-e1012. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Stack,C., Dalton,J.P. and Robinson,M.W.<br>The phylogeny, structure and function of trematode cysteine proteases, with particular emphasis on the Fasciola hepatica cathepsin L family<br>Adv Exp Med Biol (2011) 712, 116-135. PubMed  Europe PubMed DOI  V
    40. 2010
  40. Donnelly,S., O'Neill,S.M., Stack,C.M., Robinson,M.W., Turnbull,L., Whitchurch,C. and Dalton,J.P.<br>Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3<br>J Biol Chem (2010) 285, 3383-3392. PubMed  Europe PubMed DOI
  41. Golden,O., Flynn,R.J., Read,C., Sekiya,M., Donnelly,S.M., Stack,C., Dalton,J.P. and Mulcahy,G.<br>Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1)<br>Vaccine (2010) 28, 5551-5557. PubMed  Europe PubMed DOI
  42. Jaros,S., Zygner,W., Januszkiewicz,K., Jaros,D. and Wedrychowicz,H.<br>Molecular cloning and bioinformatic characterisation of FhPcW1, a new isoform of cathepsin L from adult Fasciola hepatica<br>Bull Vet Inst Pulawy (2010) 54, 585-590.
  43. Moran,B.W., Anderson,F.P., Ruth,D.M., Fagain,C.O., Dalton,J.P. and Kenny,P.T.<br>Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1<br>J Enzyme Inhib Med Chem (2010) 25, 1-12. PubMed  Europe PubMed DOI  I
  44. Perez-Ecija,R.A., Mendes,R.E., Zafra,R., Buffonni,L., Martinez-Moreno,A. and Perez,J.<br>Pathological and parasitological protection in goats immunised with recombinant cathepsin L1 and challenged with Fasciola hepatica<br>Vet J (2010) 185, 351-353. PubMed  Europe PubMed DOI
    45. 2009
  45. Kasny,M., Mikes,L., Hampl,V., Dvorak,J., Caffrey,C.R., Dalton,J.P. and Horak,P.<br>Chapter 4. Peptidases of trematodes<br>Adv Parasitol (2009) 69, 205-297. PubMed  Europe PubMed DOI  V
  46. Lowther,J., Robinson,M.W., Donnelly,S.M., Xu,W., Stack,C.M., Matthews,J.M. and Dalton,J.P.<br>The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease<br>PLoS Negl Trop Dis (2009) 3, e369-e369. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2008
  47. Dixit,A.K., Dixit,P. and Sharma,R.L.<br>Immunodiagnostic/protective role of cathepsin L cysteine proteinases secreted by Fasciola species<br>Vet Parasitol (2008) 154, 177-184. PubMed  Europe PubMed DOI  T
  48. Jezek,J., El Ridi,R., Salah,M., Wagih,A., Aziz,H.W., Tallima,H., El Shafie,M.H., Khalek,T.A., Ammou,F.F., Strongylis,C., Moussis,V. and Tsikaris,V.<br>Fasciola gigantica cathepsin L proteinase-based synthetic peptide for immunodiagnosis and prevention of sheep fasciolosis<br>Biopolymers (2008) 90, 349-357. PubMed  Europe PubMed DOI
  49. Kuk,S. and Erensoy,A.<br>[Gene cloning, selection of plasmids and application of Fasciola hepatica cathepsin L1 gene]<br>Turkiye Parazitol Derg (2008) 32, 16-22. PubMed  Europe PubMed
  50. McGonigle,L., Mousley,A., Marks,N.J., Brennan,G.P., Dalton,J.P., Spithill,T.W., Day,T.A. and Maule,A.G.<br>The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration<br>Int J Parasitol (2008) 38, 149-155. PubMed  Europe PubMed DOI
  51. Robinson,M.W., Tort,J.F., Lowther,J., Donnelly,S.M., Wong,E., Xu,W., Stack,C.M., Padula,M., Herbert,B. and Dalton,J.P.<br>Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors<br>Mol Cell Proteomics (2008) 7, 1111-1123. PubMed  Europe PubMed DOI
  52. Robinson,M.W., Dalton,J.P. and Donnelly,S.<br>Helminth pathogen cathepsin proteases: it's a family affair<br>Trends Biochem Sci (2008) 33, 601-608. PubMed  Europe PubMed DOI  V
  53. Stack,C.M., Caffrey,C.R., Donnelly,S.M., Seshaadri,A., Lowther,J., Tort,J.F., Collins,P.R., Robinson,M.W., Xu,W., McKerrow,J.H., Craik,C.S., Geiger,S.R., Marion,R., Brinen,L.S. and Dalton,J.P.<br>Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica<br>J Biol Chem (2008) 283, 9896-9908. PubMed  Europe PubMed DOI  S
    54. 2007
  54. Kesik,M., Jedlina-Panasiuk,L., Kozak-Cieszczyk,M., Plucienniczak,A. and Wedrychowicz,H.<br>Enteral vaccination of rats against Fasciola hepatica using recombinant cysteine proteinase (cathepsin L1)<br>Vaccine (2007) 25, 3619-3628. PubMed  Europe PubMed DOI
  55. Stack,C.M., Donnelly,S., Lowther,J., Xu,W., Collins,P.R., Brinen,L.S. and Dalton,J.P.<br>The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: A leu-12 to pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal<br>J Biol Chem (2007) 282, 16532-16543. PubMed  Europe PubMed DOI
  56. Wedrychowicz,H., Kesik,M., Kaliniak,M., Kozak-Cieszczyk,M., Jedlina-Panasiuk,L., Jaros,S. and Plucienniczak,A.<br>Vaccine potential of inclusion bodies containing cysteine proteinase of Fasciola hepatica in calves and lambs experimentally challenged with metacercariae of the fluke<br>Vet Parasitol (2007) 147, 77-88. PubMed  Europe PubMed DOI
    57. 2006
  57. [YEAR:27-4-2006]Raina,O.K., Yadav,S.C., Sriveny,D. and Gupta,S.C.<br>Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases<br>Acta Trop (27-4-2006) 98, 145-151. PubMed  Europe PubMed DOI
  58. [YEAR:6-7-2006]Ruth,D.M., McMahon,G. and O'Fagain,C.<br>Peptide synthesis by recombinant Fasciola hepatica cathepsin L1<br>Biochimie (6-7-2006) 88, 117-120. PubMed  Europe PubMed DOI
  59. [YEAR:17-11-2006]Sriveny,D., Raina,O.K., Yadav,S.C., Chandra,D., Jayraw,A.K., Singh,M., Velusamy,R. and Singh,B.P.<br>Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection<br>Vet Parasitol (17-11-2006) 135, 25-31. PubMed  Europe PubMed DOI
    60. 2005
  60. [YEAR:14-9-2005]Intapan,P.M., Tantrawatpan,C., Maleewong,W., Wongkham,S., Wongkham,C. and Nakashima,K.<br>Potent epitopes derived from Fasciola gigantica cathepsin L1 in peptide-based immunoassay for the serodiagnosis of human fascioliasis<br>Diagn Microbiol Infect Dis (14-9-2005) 53, 125-129. PubMed  Europe PubMed DOI  A
  61. [YEAR:13-10-2005]Yadav,S.C., Saini,M., Raina,O.K., Nambi,P.A., Jadav,K. and Sriveny,D.<br>Fasciola gigantica cathepsin-L cysteine proteinase in the detection of early experimental fasciolosis in ruminants<br>Parasitol Res (13-10-2005) 97, 527-534. PubMed  Europe PubMed DOI
    62. 2004
  62. [YEAR:30-1-2004]Collins,P.R., Stack,C.M., O'Neill,S.M., Doyle,S., Ryan,T., Brennan,G.P., Mousley,A., Stewart,M., Maule,A.G., Dalton,J.P. and Donnelly,S.<br>Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells<br>J Biol Chem (30-1-2004) 279, 17038-17046. PubMed  Europe PubMed DOI
  63. Dalton,J.P., McKerrow,J.H. and Brindley,P.J.<br>Trematode cysteine endopeptidases<br>[ISSN:0-12-079610-4] (2004) 2, 1176-1182.  V
    64. 2003
  64. [YEAR:30-9-2003]Dalton,J.P., Neill,S.O., Stack,C., Collins,P., Walshe,A., Sekiya,M., Doyle,S., Mulcahy,G., Hoyle,D., Khaznadji,E., Moire,N., Brennan,G., Mousley,A., Kreshchenko,N., Maule,A.G. and Donnelly,S.M.<br>Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines<br>Int J Parasitol (30-9-2003) 33, 1173-1181. PubMed  Europe PubMed DOI
  65. Irving,J.A., Spithill,T.W., Pike,R.N., Whisstock,J.C. and Smooker,P.M.<br>The evolution of enzyme specificity in Fasciola spp<br>J Mol Evol (2003) 57, 1-15. PubMed  Europe PubMed DOI
    66. 2002
  66. Cappetta,M., Roth,I., Diaz,A., Tort,J. and Roche,L.<br>Role of the prosegment of Fasciola hepatica cathepsin L1 in folding of the catalytic domain<br>Biol Chem (2002) 383, 1215-1221. PubMed  Europe PubMed DOI
  67. Sajid,M. and McKerrow,J.H.<br>Cysteine proteases of parasitic organisms<br>Mol Biochem Parasitol (2002) 120, 1-21. PubMed  Europe PubMed
    68. 2001
  68. Carnevale,S., Rodriguez,M.I., Guarnera,E.A., Carmona,C., Tanos,T. and Angel,S.O.<br>Immunodiagnosis of fasciolosis using recombinant procathepsin L cystein proteinase<br>Diagn Microbiol Infect Dis (2001) 41, 43-49. PubMed  Europe PubMed DOI
  69. [YEAR:3-9-2001]Cordova,M., Jara,J., Del Nery,E., Hirata,I.Y., Araujo,M.S., Carmona,A.K., Juliano,M.A. and Juliano,L.<br>Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity<br>Mol Biochem Parasitol (3-9-2001) 116, 109-115. PubMed  Europe PubMed DOI
  70. Grams,R., Vichasri-Grams,S., Sobhon,P., Upatham,E.S. and Viyanant,V.<br>Molecular cloning and characterization of cathepsin L encoding genes from Fasciola gigantica<br>Parasitol Int (2001) 50, 105-114. PubMed  Europe PubMed DOI
  71. Mulcahy,G. and Dalton,J.P.<br>Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants<br>Res Vet Sci (2001) 70, 83-86. PubMed  Europe PubMed DOI
  72. O'Neill,S.M., Mills,K.H. and Dalton,J.P.<br>Fasciola hepatica cathepsin L cysteine proteinase suppresses Bordetella pertussis-specific interferon-gamma production in vivo<br>Parasite Immunol (2001) 23, 541-547. PubMed  Europe PubMed DOI
    73. 2000
  73. Berasain,P., Carmona,C., Frangione,B., Dalton,J.P. and Goni,F.<br>Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced<br>Exp Parasitol (2000) 94, 99-110. PubMed  Europe PubMed DOI
  74. Dowd,A.J., Dooley,M., Fagain,C. and Dalton,J.P.<br>Stability studies on the cathepsin L proteinase of the helminth parasite, Fasciola hepatica<br>Enzyme Microb Technol (2000) 27, 599-604. PubMed  Europe PubMed
  75. [YEAR:14-10-2000]Hawthorne,S.J., Pagano,M., Halton,D.W. and Walker,B.<br>Partial characterization of a novel cathepsin L-like protease from Fasciola hepatica<br>Biochem Biophys Res Commun (14-10-2000) 277, 79-82. PubMed  Europe PubMed DOI
  76. [YEAR:1-7-2000]Kofta,W., Mieszczanek,J., Plucienniczak,G. and Wedrychowicz,H.<br>Successful DNA immunisation of rats against fasciolosis<br>Vaccine (1-7-2000) 18, 2985-2990. PubMed  Europe PubMed
  77. Smooker,P.M., Whisstock,J.C., Irving,J.A., Siyaguna,S., Spithill,T.W. and Pike,R.N.<br>A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica<br>Protein Sci (2000) 9, 2567-2572. PubMed  Europe PubMed DOI  PMC  EPMC
    78. 1999
  78. O'Neill,S.M., Parkinson,M., Dowd,A.J., Strauss,W., Angles,R. and Dalton,J.P.<br>Immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase<br>Am J Trop Med Hyg (1999) 60, 749-751. PubMed  Europe PubMed
  79. Piacenza,L., Acosta,D., Basmadjian,I., Dalton,J.P. and Carmona,C.<br>Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep<br>Infect Immun (1999) 67, 1954-1961. PubMed  Europe PubMed  PMC  EPMC
  80. [YEAR:25-1-1999]Roche,L., Tort,J. and Dalton,J.P.<br>The propeptide of Fasciola hepatica cathepsin L is a potent and selective inhibitor of the mature enzyme<br>Mol Biochem Parasitol (25-1-1999) 98, 271-277. PubMed  Europe PubMed DOI
  81. Strauss,W., O'Neill,S.M., Parkinson,M., Angles,R. and Dalton,J.P.<br>Diagnosis of human fascioliasis: detection of anti-cathepsin L antibodies in blood samples collected on filter paper<br>Am J Trop Med Hyg (1999) 60, 746-748. PubMed  Europe PubMed
  82. Tort,J., Brindley,P.J., Knox,D., Wolfe,K.H. and Dalton,J.P.<br>Proteinases and associated genes of parasitic helminths<br>Adv Parasitol (1999) 43, 161-266. PubMed  Europe PubMed  V
    83. 1998
  83. Wilson,L.R., Good,R.T., Panaccio,M., Wijffels,G.L., Sandeman,R.M. and Spithill,T.W.<br>Fasciola hepatica: Characterization and cloning of the major cathepsin B protease secreted by newly excysted juvenile liver fluke<br>Exp Parasitol (1998) 88, 85-94. PubMed  Europe PubMed DOI
    84. 1997
  84. Berasain,P., Goni,F., McGonigle,S., Dowd,A., Dalton,J.P., Frangione,B. and Carmona,C.<br>Proteinases secreted by Fasciola hepatica degrade extracellular matrix and basement membrane components<br>J Parasitol (1997) 83, 1-5. PubMed  Europe PubMed DOI
  85. [YEAR:15-4-1997]Roche,L., Dowd,A.J., Tort,J., McGonigle,S., McSweeney,A., Curley,G.P., Ryan,T., Dalton,J.P. and McSweeney,A.<br>Functional expression of Fasciola hepatica cathepsin L1 in Saccharomyces cerevisiae<br>Eur J Biochem (15-4-1997) 245, 373-380. PubMed  Europe PubMed  E
    86. 1996
  86. Bozas,S.E. and Spithill,T.W.<br>Identification of 3-hydroxyproline residues in several proteins of Fasciola hepatica<br>Exp Parasitol (1996) 82, 69-72. PubMed  Europe PubMed DOI
  87. Dalton,J.P., McGonigle,S., Rolph,T.P. and Andrews,S.J.<br>Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin<br>Infect Immun (1996) 64, 5066-5074. PubMed  Europe PubMed  PMC  EPMC
    88. 1994
  88. Heussler,V.T. and Dobbelaere,D.A.<br>Cloning of a protease gene family of Fasciola hepatica by the polymerase chain reaction<br>Mol Biochem Parasitol (1994) 64, 11-23. PubMed  Europe PubMed DOI
  89. Wijffels,G.L., Salvatore,L., Dosen,M., Waddington,J., Wilson,L., Thompson,C., Campbell,N., Sexton,J., Wicker,J. and Bowen,F.<br>Vaccination of sheep with purified cysteine proteinases of Fasciola hepatica decreases worm fecundity<br>Exp Parasitol (1994) 78, 132-148. PubMed  Europe PubMed DOI
    90. 1993
  90. Smith,A.M., Dowd,A.J., McGonigle,S., Keegan,P.S., Brennan,G., Trudgett,A. and Dalton,J.P.<br>Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica<br>Mol Biochem Parasitol (1993) 62, 1-8. PubMed  Europe PubMed DOI
  91. Smith,A.M., Dowd,A.J., Heffernan,M., Robertson,C.D. and Dalton,J.P.<br>Fasciola hepatica: a secreted cathepsin L-like proteinase cleaves host immunoglobulin<br>Int J Parasitol (1993) 23, 977-983. PubMed  Europe PubMed DOI
  92. Yamasaki,H. and Aoki,T.<br>Cloning and sequence analysis of the major cysteine protease expressed in the trematode parasite Fasciola sp<br>Biochem Mol Biol Int (1993) 31, 537-542. PubMed  Europe PubMed
    93. 1992
  93. Fagbemi,B.O. and Hillyer,G.V.<br>The purification and characterization of a cysteine protease of Fasciola gigantica adult worms<br>Vet Parasitol (1992) 43, 223-232. PubMed  Europe PubMed
  94. Yamasaki,H., Kominami,E. and Aoki,T.<br>Immunocytochemical localization of a cysteine protease in adult worms of the liver fluke Fasciola sp<br>Parasitol Res (1992) 78, 574-580. PubMed  Europe PubMed
    95. 1991
  95. Fagbemi,B.O. and Hillyer,G.V.<br>Partial purification and characterisation of the proteolytic enzymes of Fasciola gigantica adult worms<br>Vet Parasitol (1991) 40, 217-226. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use