$VAR1 = undef;

Summary for peptidase A02.015: Rous sarcoma virus retropepsin

Names
MEROPS Name	Rous sarcoma virus retropepsin
Other names	avian myeloblastosis virus retropepsin, avian sarcoma virus endopeptidase, RSV protease, retropepsin (Rous sarcoma virus), avian leucosis virus endopeptidase, retropepsin (avian myeloblastosis virus)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily X >> A02.015
Holotype	Rous sarcoma virus retropepsin (Rous avian sarcoma virus), Uniprot accession P03322 (peptidase unit: 583-700), MERNUM MER0000972
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00035
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (2 cleavages)
Physiology	Processing of viral polyprotein in fowl pathogen.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	S/q/N/YlP/I/V/Q (based on 18 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	0	0	0	0	0	0
Pro	2	0	0	0	14	0	0	0
Ala	2	2	1	1	1	1	2	0
Val	0	1	3	0	0	3	14	0
Leu	0	2	0	3	1	1	0	2
Ile	0	0	1	0	0	13	0	0
Met	0	0	0	1	0	0	1	0
Phe	1	1	0	1	0	0	0	0
Tyr	0	0	0	10	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	13	0	0	1	0	0	0	0
Thr	0	2	0	0	2	0	0	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	13	0	0	0	0	1
Gln	0	8	0	0	0	0	0	13
Asp	0	0	0	0	0	0	0	0
Glu	0	0	0	0	0	0	0	1
Lys	0	1	0	0	0	0	0	0
Arg	0	0	0	0	0	0	1	0
His	0	0	0	0	0	0	0	0