Substrates for peptidase A02.015: Rous sarcoma virus retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
gag polyprotein P03322 1-701 peptide-Met488+Ala-peptide P Pro Leu Ile Mer Ala Val Val Asn Grinde et al., 1992 16002
Gag-Pol polyprotein (Rous sarcoma virus) peptide-Leu701+Thr-peptide P Ala Thr Val Leu Thr Val Ala Leu Tözsér et al., 1996
pol polyprotein P03354 1-1603 peptide-Tyr572+Pro-peptide P Phe Gln Ala Tyr Pro Leu Arg Glu Tözsér et al., 1996 16004
Pro-Ala-The-Val-Leu-Thr-Val-Ala-Leu-Arg-Arg Pro-Ala-The-Val-Leu+Thr-Val-Ala-Leu-Arg-Arg N Ala Thr Val Leu Thr Val Ala Leu Ridky & Leis, 1998
Pro-Pro-Ala-Val-Ser-Leu-Ala-Met-Thr-Met-Arg-Arg Pro-Pro-Ala-Val-Ser+Leu-Ala-Met-Thr-Met-Arg-Arg N Pro Ala Val Ser Leu Ala Met Thr Ridky & Leis, 1998
Val-Ser-Ala-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Ala Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Ala-Pro-Ile-Val-Gln peptide-Ala5+Pro-peptide N AA Ser Gln Asn Ala Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Leu-Pro-Ile-Val-Gln peptide-Leu5+Pro-peptide N AA Ser Gln Asn Leu Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Met-Pro-Ile-Val-Gln peptide-Met5+Pro-peptide N AA Ser Gln Asn Met Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Phe-Pro-Ile-Val-Gln peptide-Phe5+Pro-peptide N AA Ser Gln Asn Phe Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gly-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gly Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Leu-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Leu Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Lys-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Lys Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Phe-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Phe Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Val-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Val Asn Tyr Pro Ile Val Gln Eizert et al., 2008