| Activity |
|---|
| Catalytic type | Serine |
| Peplist | Included in the Peplist with identifier PL00359 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.93
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (54 cleavages) |
| Activity status | human: active (Seidah & Chretien, 2004)
mouse: active (Jean et al., 1993)
|
| Physiology | Processes various preproteins by cleavage at paired basic amino acids. |
| Knockout | Work with a mouse knock-out led to the conclusion that proprotein convertase 1 plays a major role in processing proinsulin, but that its coordinated action with PC2 is necessary for the most efficient and complete processing of this prohormone (Zhu et al., 2002). Impaired intestinal proglucagon processing was detected in mice lacking prohormone convertase 1 (Ugleholdt et al., 2003). Jackson et al. (2003) have described two human cases of deficiency, both presenting obesity, hypoadrenalism and reactive hypoglycemia. |
|
Other databases
| TREEFAM | http://www.treefam.org/family/TF314277 |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/-/Kr/R -/-/ep/- (based on 97 cleavages) |
