Inhibitors for peptidase C01.040: cathepsin H

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

MERID	Inhibitor	Inhibitor name	Ki	Conditions	Reference
I25.001	cystatin A		0.31 nM		Barrett et al., 1986
I25.003	cystatin B		0.58 nM		Barrett et al., 1986
I25.004	cystatin C		0.28 nM		Barrett et al., 1986
I25.005	cystatin D		8.5 nM		Abrahamson, 1994
I25.007	cystatin F				Prunk et al., 2020
I25.011	ovocystatin		0.064 nM		Barrett et al., 1986
I25.028	oryzacystatin II		10 nM		Kondo et al., 1990
I25.031	onchocystatin				Newlands et al., 2001
I25.033	phytocystatin (Actinidia sp.)		0.049 nM		Rassam & Laing, 2004
I25.064	cystatin RHcyst-1 (Rhipicephalus haemaphysaloides)	Rhcyst-1			<%Wang et al., 2015%>
I25.UPA	subfamily I25A unassigned peptidase inhibitors	FhCyLS-2 ({Fasciola hepatica})			Busa et al., 2023
I29.002	cytotoxic T-lymphocyte antigen-2 alpha				Delaria et al., 1994
I29.003	cathepsin H propeptide
I29.008	cytotoxic T-lymphocyte antigen-2 beta				Delaria et al., 1994
I29.009	crammer peptidase inhibitor		7.8 nM		Deshapriya et al., 2007
I31.002	MHC II invariant chain p41 form				Bevec et al., 1996
I39.001	alpha-2-macroglobulin				Barrett, 1981
I71.001	falstatin		0.052 nM		Pandey et al., 2006
I85.001	macrocypin 1		370 nM	natural inhibitor	Sabotic et al., 2009
I85.002	macrocypin 3		24 nM	recombinant form	Sabotic et al., 2009
I85.003	macrocypin 4		32 nM	recombinant form	Sabotic et al., 2009
	iodoacetate			half-time: 3591s at 10 microM	Salvesen & Nagase, 2001
	leupeptin				Kirschke et al., 1977
	azapeptide inhibitors of cysteine peptidases	MW4			Verhelst et al., 2006
	E64			half-time: 17s at 10 microM inhibitor	Salvesen & Nagase, 2001
	TLCK				Matsuishi et al., 2003
	ZVAD-FMK				Schotte et al., 1999
LI25.002	kininogen		0.72 nM		Abrahamson, 1994
LI25.002	kininogen		1.2 nM		Barrett et al., 1986
LI25.003	T-kininogen		130 nM		Moreau et al., 1988