Resolution: 2.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qn6
Q-score: 0.645
Yang Y, Murzin AG, Peak-Chew S, Franco C, Garringer HJ, Newell KL, Ghetti B, Goedert M, Scheres SHW
Acta Neuropathol (2023) 11 pp. 191-191 [ Pubmed: 38049918 DOI: doi:10.1186/s40478-023-01694-8 ]
- Amyloid-beta a4 protein (4 kDa, Protein from Homo sapiens)
- Amyloid-beta 40 (Tissue from Homo sapiens)
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qn7
Q-score: 0.66
Yang Y, Murzin AG, Peak-Chew S, Franco C, Garringer HJ, Newell KL, Ghetti B, Goedert M, Scheres SHW
Acta Neuropathol (2023) 11 pp. 191-191 [ Pubmed: 38049918 DOI: doi:10.1186/s40478-023-01694-8 ]
Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT
Resolution: 2.61 Å
EM Method: Helical reconstruction
Fitted PDBs: 8p34
Q-score: 0.647
Schweighauser M, Garringer HJ, Klingstedt T, Nilsson KPR, Masuda-Suzukake M, Murrell JR, Risacher SL, Vidal R, Scheres SHW, Goedert M, Ghetti B, Newell KL
Acta Neuropathol (2023) 146 pp. 211-226 [ Pubmed: 37351604 DOI: doi:10.1007/s00401-023-02598-6 ]
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ceb
Q-score: 0.595
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
Alpha-synuclein filament assembled in vitro with mutant (7 residues insertion) protein
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
WT alpha-synuclein filament assembled in vitro
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ce7
Q-score: 0.606
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqv
Q-score: 0.74
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
- Alpha-synuclein (14 kDa, Protein from human)
- Unknown protein (613 Da, Protein from Human)
- Water (18 Da, Ligand)
- Alpha-synuclein singlet filament extracted from the human brain with jos (Tissue from Homo sapiens)
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqw
Q-score: 0.652
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
- Alpha-synuclein (14 kDa, Protein from human)
- Alpha-synuclein doublet filament extracted from the human brain with jos (Tissue from Homo sapiens)
- Unknown protein (783 Da, Protein from Human)
- Water (18 Da, Ligand)
Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M
Nature (2022) 610 pp. 791-795 [ DOI: 10.1038/s41586-022-05319-3 Pubmed: 36108674 ]
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