EMD-15285
Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies
EMD-15285
Helical reconstruction2.2 Å
Deposition: 28/06/2022Map released: 31/08/2022
Last modified: 24/07/2024
Sample Organism:
Homo sapiens
Sample: Alpha-synuclein filaments extracted from the human brain with PD, PDD, and DLB
Fitted models: 8a9l
Deposition Authors: Yang Y
,
Shi Y ,
Schweighauser M ,
Zhang XJ,
Kotecha A ,
Murzin AG,
Garringer HJ ,
Cullinane P,
Saito Y,
Foroud T ,
Warner TT ,
Hasegawa K,
Vidal R ,
Murayama S,
Revesz T,
Ghetti B ,
Hasegawa M ,
Lashley T ,
Scheres HWS,
Goedert M
Sample: Alpha-synuclein filaments extracted from the human brain with PD, PDD, and DLB
Fitted models: 8a9l
Deposition Authors: Yang Y
,
Shi Y ,
Schweighauser M ,
Zhang XJ,
Kotecha A ,
Murzin AG,
Garringer HJ ,
Cullinane P,
Saito Y,
Foroud T ,
Warner TT ,
Hasegawa K,
Vidal R ,
Murayama S,
Revesz T,
Ghetti B ,
Hasegawa M ,
Lashley T ,
Scheres HWS,
Goedert M
Structures of alpha-synuclein filaments from human brains with Lewy pathology.
Yang Y ,
Shi Y ,
Schweighauser M ,
Zhang X,
Kotecha A ,
Murzin AG,
Garringer HJ ,
Cullinane PW ,
Saito Y,
Foroud T ,
Warner TT ,
Hasegawa K,
Vidal R ,
Murayama S,
Revesz T,
Ghetti B ,
Hasegawa M ,
Lashley T ,
Scheres SHW ,
Goedert M
(2022) Nature , 610 , 791 - 795
,
Shi Y ,
Schweighauser M ,
Zhang X,
Kotecha A ,
Murzin AG,
Garringer HJ ,
Cullinane PW ,
Saito Y,
Foroud T ,
Warner TT ,
Hasegawa K,
Vidal R ,
Murayama S,
Revesz T,
Ghetti B ,
Hasegawa M ,
Lashley T ,
Scheres SHW ,
Goedert M
(2022) Nature , 610 , 791 - 795
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_UP_A025_1013 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_U105184291 to M.G. (United Kingdom)
- Alzheimers Research UK (ARUK): (United Kingdom)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): (United States)